CN103536866A - Traditional Chinese medicine composition for treating inflammatory intestinal obstruction after abdominal operation and application thereof - Google Patents
Traditional Chinese medicine composition for treating inflammatory intestinal obstruction after abdominal operation and application thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating inflammatory intestinal obstruction after abdominal operation and application thereof. The composite is prepared from the following components in parts by weight: 22-35 parts of cassia seed, 22-35 parts of lalang grass rhizome, 40-56 parts of dried tangerine or orange peel, 16-24 parts of curcuma zedoary, 16-24 parts of radix angelicae, 22-35 parts of herba patriniae, 22-35 parts of perilla leaf, 13-22 parts of roasted Rhizoma Atractylodis Macrocephalae, 13-22 parts of roasted fructus aurantii, 50-70 parts of lotus leaf and 8-16 parts of licorice root. The traditional Chinese medicine composition provided by the invention is used for treating inflammatory intestinal obstruction in early stage after abdominal operation, not only can quickly eliminate the intestinal obstruction symptoms, but also can remove inflammation after enteric cavity operation.
Description
technical field
The present invention relates to a kind of Chinese medicine composition and application thereof for the treatment of abdominal postoperative postoperative inflammatory small bowel obstruction, belong to technical field of Chinese medicines.
Background technology
Postoperative inflammatory small bowel obstruction is a kind of early stage disease, and in all intestinal obstruction, morbidity the earliest, if do not treated in time, is easy to, to the development of viscosity intestinal obstruction, even change strangulated intestinal obstruction into, adds greatly heavy patient's misery, injures patient's life.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition and application thereof for the treatment of abdominal postoperative postoperative inflammatory small bowel obstruction.
The object of the present invention is achieved like this:
Treat a Chinese medicine composition for abdominal postoperative postoperative inflammatory small bowel obstruction, it is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Semen Cassiae 22-35 part, Rhizoma Imperatae 22-35 part, Pericarpium Citri Reticulatae 40-56 part, Rhizoma Curcumae 16-24 part, Radix Angelicae Dahuricae 16-24 part, Herba Patriniae 22-35 part, Folium Perillae 22-35 part, Rhizoma Atractylodis Macrocephalae (parched) 13-22 part, Fructus Aurantii (parched) 13-22 part, Folium Nelumbinis 50-70 part, Radix Glycyrrhizae 8-16 part.
Preferably, the Chinese medicine composition for the treatment of abdominal postoperative postoperative inflammatory small bowel obstruction as above, it is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Semen Cassiae 22-30 part, Rhizoma Imperatae 22-30 part, Pericarpium Citri Reticulatae 40-50 part, Rhizoma Curcumae 16-20 part, Radix Angelicae Dahuricae 16-20 part, Herba Patriniae 22-30 part, Folium Perillae 22-30 part, Rhizoma Atractylodis Macrocephalae (parched) 13-20 part, Fructus Aurantii (parched) 13-20 part, Folium Nelumbinis 50-65 part, Radix Glycyrrhizae 8-14 part.
In most preferred embodiment of the present invention, it is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: 30 parts of Semen Cassiaes, 30 parts of Rhizoma Imperataes, 48 parts of Pericarpium Citri Reticulataes, 20 parts of Rhizoma Curcumae, 20 parts of the Radixs Angelicae Dahuricae, 30 parts of Herba Patriniae, 30 parts of Folium Perillae, 18 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 18 parts of Fructus Aurantii (parched), 60 parts, Folium Nelumbinis, 12 parts, Radix Glycyrrhizae.
The Chinese medicine composition of further preferably, described treatment abdominal postoperative postoperative inflammatory small bowel obstruction is liquid preparation.
By a large amount of clinical experimental studies, find, the pharmaceutical composition being prepared from by above-mentioned traditional Chinese medicinal material raw materials has significant curative effect aspect treatment abdominal postoperative postoperative inflammatory small bowel obstruction.Therefore, second object of the present invention is to provide a kind of new medical use, i.e. the application of above-mentioned Chinese medicine composition in the medicine of preparation treatment abdominal postoperative postoperative inflammatory small bowel obstruction.
According to Chinese medicine Historical Data Data About, above-mentioned traditional Chinese medicinal material raw materials has following pharmacologically active and function cures mainly: Semen Cassiae: clearing away heat to improve acuity of vision, intestine moistening is logical.For the puckery pain of conjunctival congestion, the many tear of photophobia, has a headache dizzy, poor vision, constipation.Select the dry mature seed of pulse family annual herb plant Semen Cassiae or little Semen Cassiae.Rhizoma Imperatae: removing heat from blood, hemostasis, heat clearing away, diuresis.Control calentura excessive thirst, spit blood, epistaxis, lung-heat dyspnea with rapid respiration, gastric heat hiccup, gonorrhea, dysuria, edema, jaundice.Select the dry rhizome of grass Herba Imperatae Imperata cylindrical (L.) Beauv. var. major (Nees) C. E. Hubb..Pericarpium Citri Reticulatae: there is regulating qi-flowing for strengthening spleen, in tune, dampness, the effect of reducing phlegm.Cure mainly the distension and fullness in the abdomen of stagnation of QI in spleen and stomach or pain, dyspepsia.Abdominal distention uncomfortable in chest, indigestion and loss of appetite loose stool in turbid damp resistance.Phlegm-damp is stopped up the cough and asthma of lung.Select the dry mature skin for rutaceae orange and variety thereof.Rhizoma Curcumae: circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.For Dan abdominal mass mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain; Early cervical carcinoma.Select the rhizome of zingiberaceous plant osmanthus Rhizoma Curcumae Curcuam kwangsiensis S.G.Leset C.F.Liang.The Radix Angelicae Dahuricae: wind-damp dispelling, the evacuation of pus of invigorating blood circulation, granulation promoting pain relieving.For headache, toothache, nasal sinusitis, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus.Select the root of samphire angelica anomala.Herba Patriniae: have another name called Herba Ixeritis chinensis, select herb and the root of feverfew Herba Ixeritis chinensis.Herba Patriniae heat-clearing and toxic substances removing, removing heat from blood, eliminating carbuncle evacuation of pus, stasis-dispelling and pain-killing.For acute appendicitis, the high heat of lung abscess, coughs vomiting bloody pus, pyretic toxicity skin ulcer furuncle, and furuncle is bitterly swollen, breast abdomen pain, appendicitis, enteritis, dysentery, puerperal abdonimal pain, dysmenorrhea.Folium Perillae: expelling cold and relieving exterior syndrome, regulating the flow of QI to ease the stomach.For anemofrigid cold, headache, cough, distension and fullness of the chest and abdomen.Select the leaf of labiate wrinkle Folium Perillae, sharp Folium Perillae etc.The Rhizoma Atractylodis Macrocephalae: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Select the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Fructus Aurantii: regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.For the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention; Gastroptosis, proctoptosis, sub-official's prolapsus.Select the dry immature fruit of rutaceae Citrus aurantium Linn. Citrus aurantium L..Folium Nelumbinis: clearing away summer-heat, sending up the lucid YANG, cooling blood for hemostasis.For summer-heat excessive thirst, diarrhea due to summer heat and dampness, diarrhea due to hypofunction of the spleen, heat in blood is told nosebleed, the metrorrhagia of having blood in stool.Select the dried leaves of nymphaeaceae plant lotus Nelumbo nuciferaGaertn..Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Select the Fisch. for dicotyledon pulse family Leguminosae Radix Glycyrrhizae Glycyrrhiza uralensis, Glycyrrhiza inflata Bat. G. inflata Bat., or the root and rhizome of Glycyrrhiza glabra L. G. glabra L..
Above-mentioned each Chinese crude drug is prepared into the preparation method of compound recipe medicinal liquid of the present invention, comprise the steps: to take and clean up and dry medical material merging, decoct with water twice, collecting decoction, while being evaporated to 70 ℃, relative density is 1.15-1.20, adding ethanol makes to reach 75-85% containing the percent by volume of alcohol amount, stir, standing, filter, when filtrate decompression is concentrated into 65 ℃, relative density is 1.25-1.30 and reclaims ethanol and obtain concentrated solution, concentrated solution is added to water and adjuvant is mixed with medicinal liquid.
Chinese medicine composition of the present invention is used for the treatment of the early stage postoperative inflammatory small bowel obstruction occurring of abdominal postoperative, both can eliminate faster the ileac symptom of patient, the postoperative inflammation of enteric cavity can disappear again, alleviate the load of intestinal tube, promote the absorption of intestinal juice, prevent from forming between intestinal tube adhesion, be conducive to the recovery of gastrointestinal function, thereby reach analgesic antiphlogistic, reduce the incidence rate of complication, make patient's early recovery.
The specific embodiment
Below by embodiment, further illustrate the present invention.Embodiments of the invention are only used for illustrating the present invention, rather than limitation of the present invention, under design prerequisite of the present invention, the simple modifications of preparation method of the present invention are all belonged to the scope of protection of present invention.
Embodiment 1
Crude drug prescription: Semen Cassiae 3kg, Rhizoma Imperatae 3kg, Pericarpium Citri Reticulatae 4.8kg, Rhizoma Curcumae 2kg, Radix Angelicae Dahuricae 2kg, Herba Patriniae 3kg, Folium Perillae 3kg, Rhizoma Atractylodis Macrocephalae (parched) 1.8kg, Fructus Aurantii (parched) 1.8kg, Folium Nelumbinis 6kg, Radix Glycyrrhizae 1.2kg.
Preparation method: the medical material that takes above-mentioned recipe quantity merges, decoct with water twice, adding for the first time water is 10 times of amounts of medical material weight, decoct 2h, adding for the second time water is 8 times of amounts of medical material weight, decoct 1.5h, collecting decoction, while being evaporated to 70 ℃ at 0.08MPa, 70 ℃, relative density is 1.15, adds 95% (v/v) ethanol and makes to reach 75% (v/v) containing alcohol amount, stirs, hold over night, filter, when filtrate concentrating under reduced pressure under 0.08MPa, 65 ℃ of conditions becomes to 65 ℃, relative density is 1.30, adds water and sucrose is mixed with medicinal liquid.
Embodiment 2
Crude drug prescription: Semen Cassiae 2.2kg, Rhizoma Imperatae 3.4kg, Pericarpium Citri Reticulatae 5.6kg, Rhizoma Curcumae 1.6kg, Radix Angelicae Dahuricae 1.6kg, Herba Patriniae 2.2kg, Folium Perillae 3.4kg, Rhizoma Atractylodis Macrocephalae (parched) 2.2kg, Fructus Aurantii (parched) 2kg, Folium Nelumbinis 5.1kg, Radix Glycyrrhizae 1kg.
Preparation method: the medical material that takes above-mentioned recipe quantity merges, decoct with water twice, adding for the first time water is 10 times of amounts of medical material weight, decoct 2h, adding for the second time water is 8 times of amounts of medical material weight, decoct 1.5h, collecting decoction, while being evaporated to 70 ℃ at 0.08MPa, 70 ℃, relative density is 1.15, adds 95% (v/v) ethanol and makes to reach 85% (v/v) containing alcohol amount, stirs, hold over night, filter, when filtrate concentrating under reduced pressure under 0.08MPa, 65 ℃ of conditions becomes to 65 ℃, relative density is 1.30, adds water and sucrose is mixed with medicinal liquid.
Embodiment 3
Crude drug prescription: Semen Cassiae 3.5kg, Rhizoma Imperatae 2.2kg, Pericarpium Citri Reticulatae 4.2kg, Rhizoma Curcumae 2.2kg, Radix Angelicae Dahuricae 2kg, Herba Patriniae 3.5kg, Folium Perillae 2.2kg, Rhizoma Atractylodis Macrocephalae (parched) 2kg, Fructus Aurantii (parched) 1.5kg, Folium Nelumbinis 7kg, Radix Glycyrrhizae 1.5kg.
Preparation method: the medical material that takes above-mentioned recipe quantity merges, decoct with water twice, adding for the first time water is 10 times of amounts of medical material weight, decoct 2h, adding for the second time water is 8 times of amounts of medical material weight, decoct 1.5h, collecting decoction, while being evaporated to 70 ℃ at 0.08MPa, 70 ℃, relative density is 1.20, adds 95% (v/v) ethanol and makes to reach 80% (v/v) containing alcohol amount, stirs, hold over night, filter, when filtrate concentrating under reduced pressure under 0.08MPa, 65 ℃ of conditions becomes to 65 ℃, relative density is 1.30, adds water and sucrose is mixed with medicinal liquid.
The impact of embodiment 4 Chinese medicine composition of the present invention on severe abdominal postoperative postoperative inflammatory small bowel obstruction patient
Traditional Chinese medicine sample preparation: take 30 parts of Semen Cassiaes, 30 parts of Rhizoma Imperataes, 48 parts of Pericarpium Citri Reticulataes, 20 parts of Rhizoma Curcumae, 20 parts of the Radixs Angelicae Dahuricae, 30 parts of Herba Patriniae, 30 parts of Folium Perillae, 18 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 18 parts of Fructus Aurantii (parched), 12 parts, 60 parts, Folium Nelumbinis and Radix Glycyrrhizae, the medical material of above-mentioned recipe quantity is merged, decoct with water twice, adding for the first time water is 10 times of amounts of medical material weight, decoct 2h, adding for the second time water is 8 times of amounts of medical material weight, decoct 1.5h, collecting decoction, 0.08MPa, while being evaporated to 70 ℃ at 70 ℃, relative density is 1.15, adding 95% (v/v) ethanol makes to reach 75% (v/v) containing alcohol amount, stir, hold over night, filter, filtrate is at 0.08MPa, when under 65 ℃ of conditions, concentrating under reduced pressure becomes to 65 ℃, relative density is 1.30, .
Be diagnosed as and suffer from the ileac 92 routine patients of abdominal post-operation, the age, in year mean age (29.40 ± 5.07), fever time was 4～12 d at 23～50 years old, and average fever time is (6.4 ± 1.9) d.Carry out abdominal postoperative vomit, bitterly, close, swollen be patient's cardinal symptom.All patients are divided into Chinese drug-treated group (47 example) and matched group (45 example) at random, and two groups do not have significant difference at aspects such as sex, age, the courses of disease, have comparability.
The traditional Chinese medicine sample medicinal liquid that Chinese drug-treated group is used said method to prepare, concrete grammar is as follows: each oral 100mL medicinal liquid, every day is sooner or later respectively once; Get 100mL for low level retention enema, once a day simultaneously.Matched group patient uses traditional Western medicine therapy to treat, and concrete method is: acupoint injection therapy vitamin B
1, intramuscular injection neostigmine, and carry out coloclysis with the normal saline of same volume.Observe and compare the improvement degree of the symptoms such as two groups of patient's abdominal distention stomachache, micturition time, indigestion and loss of appetite and nausea and vomiting.The standard of curative effect judgement is as follows:
Cure: through cardinal symptom disappearance and anus within treatment 48 h after surgery, start aerofluxus;
Effective: through cardinal symptom disappearance or anus within treatment 48～72 h after surgery, to start aerofluxus;
Effective: through cardinal symptom disappearance or anus within treatment 72～96 h after surgery, to start aerofluxus;
Invalid: through treating after surgery 96h and abnormal cardinal symptom does not disappear or anus does not have aerofluxus.
Result of the test shows, Chinese drug-treated group patient is obviously better than matched group for the improvement degree of patient's symptom, and total effective rate is also obviously high than matched group, illustrate that traditional Chinese medicine composition for treating abdominal post-operation postoperative inflammatory small bowel obstruction of the present invention has good clinical efficacy, specifically referring to table 1.
Table 1 liang group patient general curative effect comparison
Claims (5)
1. a Chinese medicine composition for the treatment of abdominal postoperative postoperative inflammatory small bowel obstruction, is characterized in that: described Chinese medicine composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Semen Cassiae 22-35 part, Rhizoma Imperatae 22-35 part, Pericarpium Citri Reticulatae 40-56 part, Rhizoma Curcumae 16-24 part, Radix Angelicae Dahuricae 16-24 part, Herba Patriniae 22-35 part, Folium Perillae 22-35 part, Rhizoma Atractylodis Macrocephalae (parched) 13-22 part, Fructus Aurantii (parched) 13-22 part, Folium Nelumbinis 50-70 part, Radix Glycyrrhizae 8-16 part.
2. the Chinese medicine composition for the treatment of abdominal postoperative postoperative inflammatory small bowel obstruction according to claim 1, is characterized in that: described Chinese medicine composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Semen Cassiae 22-30 part, Rhizoma Imperatae 22-30 part, Pericarpium Citri Reticulatae 40-50 part, Rhizoma Curcumae 16-20 part, Radix Angelicae Dahuricae 16-20 part, Herba Patriniae 22-30 part, Folium Perillae 22-30 part, Rhizoma Atractylodis Macrocephalae (parched) 13-20 part, Fructus Aurantii (parched) 13-20 part, Folium Nelumbinis 50-65 part, Radix Glycyrrhizae 8-14 part.
3. the Chinese medicine composition for the treatment of abdominal postoperative postoperative inflammatory small bowel obstruction according to claim 1, is characterized in that: described Chinese medicine composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: 30 parts of Semen Cassiaes, 30 parts of Rhizoma Imperataes, 48 parts of Pericarpium Citri Reticulataes, 20 parts of Rhizoma Curcumae, 20 parts of the Radixs Angelicae Dahuricae, 30 parts of Herba Patriniae, 30 parts of Folium Perillae, 18 parts of Rhizoma Atractylodis Macrocephalae (parched)s, 18 parts of Fructus Aurantii (parched), 60 parts, Folium Nelumbinis, 12 parts, Radix Glycyrrhizae.
4. according to the Chinese medicine composition of the treatment abdominal postoperative postoperative inflammatory small bowel obstruction described in claim 1,2 or 3, it is characterized in that: described Chinese medicine composition is liquid preparation.
5. the application of the pharmaceutical composition described in claim 1,2 or 3 in the medicine of preparation treatment abdominal postoperative postoperative inflammatory small bowel obstruction.
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| CN103920094A (en) * | 2014-04-25 | 2014-07-16 | 王志伟 | Traditional Chinese medicine composition used after abdominal surgical operation |
| CN105194459A (en) * | 2015-10-21 | 2015-12-30 | 刘凯 | Medicine composition for preventing postoperative inflammatory ileus and application thereof |
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| CN1511544A (en) * | 2002-12-27 | 2004-07-14 | 贵阳新天药业股份有限公司 | Traditional Chinese medicine compound preparation for preventing and treating intestinal adhesion and preparing method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103920094A (en) * | 2014-04-25 | 2014-07-16 | 王志伟 | Traditional Chinese medicine composition used after abdominal surgical operation |
| CN105194459A (en) * | 2015-10-21 | 2015-12-30 | 刘凯 | Medicine composition for preventing postoperative inflammatory ileus and application thereof |
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