CN104225363A - Pharmaceutical preparation for treating cerebral thrombosis - Google Patents

Abstract

The invention provides a pharmaceutical preparation for treating the cerebral thrombosis. The pharmaceutical preparation comprises bulk drugs such as christina loosestrife, pollen typhae, rhizoma alismatis, peach kernels, ligusticum wallichii, siegesbeckiae Herba, haws, hirudo, xanthii fructus, tabasheer, coicis semen, acanthopanacis senticosi radix et rhizoma seu caulis, astragali radix, spatholobi caulis, sappanlignum, salvia miltiorrhiza, acori calami rhizoma, gordon euryale, cochinchinese asparagus roots, mongolian snakegourd, angelica roots, pummelo peels, encomia bark, myristicae semen, conyza japonica, salvia, Chinese taxillus herb, radix et rhizome rhei franzenbachii, herba gei and heterophylly falsestarwort roots. The pharmaceutical preparation is superior to the western medicine in treatment effect and is convenient and safe to take, free of toxic and side effects, cheap and worthy of popularization and application.

Description

Be used for the treatment of the pharmaceutical preparation of cerebral thrombosis

Technical field

The present invention relates to technical field of Chinese medicine, particularly relate to a kind of pharmaceutical preparation being used for the treatment of cerebral thrombosis.

Background technology

Cerebral thrombosis belongs to ischemia type in cerebrovascular disease, in brain after arterial wall damage, in the situations such as the rising of body blood viscosity and reduced velocity flow, cause thrombosis, thus degeneration after cerebral tissue generation ischemia, anoxia, necrosis in the blood supply region that result in lesion vessels, clinically there is the symptoms such as hemidysesthesia, hemiplegia, voice are ambiguous.Cerebral thrombosis is common cerebrovascular disease, and in being apt to occur in, old people, mortality rate and disability rate are all higher, and poor prognosis, and cerebral thrombosis was more common between 50 ~ 70 years old suffers from arteriosclerotic old people, and male is more than women.Transient ischemic attack medical history is had before about 25% diseases.At present, doctor trained in Western medicine does not have effective medicine in the treatment of cerebral thrombosis, and in the treatment of cerebral thrombosis disease, the application of the medicine such as anticoagulation medicine, trophic nerve cell focused on by Western medicine.

Cerebral thrombosis belongs to the traditional Chinese medical science " apoplexy " category, and characteristic of disease belongs to deficiency in origin and excess in superficiality; Deficiency of qi and blood, the hepatic and renal YIN deficiency is pathogenic basis; Healthy energy virtual loss, blood stagnancy due to deficiency of QI, venation block is main pathogenesis.The diseased region of primary disease, based on head, often relates to the heart, liver,kidney,spleen and network, blood vessels.The cause of disease is damaged so that internal injury is long-pending, kidney Qi deficiency in addition, and YANG QI deficiency, causes QI-blood circulation and be obstructed, and skin muscle arteries and veins loses in moistening foster and is disease.State of an illness the lighter is only limitted to blood vessels meridians, severe one ordinary wave and relevant internal organs.From seeing that cerebral thrombus patient all has hemiplegia, numbness, fear of cold in various degree clinically, being one deficiency of vital energy, the resistance of blood numbness, limbs lose and resemble in warm, thus think the deficiency of vital energy weak be cause this pathogenetic intrinsic factor.Blood stasis due to qi deficiency, passages through which vital energy circulates stasis blocking are main pathomechanism.Therefore, the method taking benefiting QI for activating blood circulation, eliminating blood stasis and smoothing collaterals, nourishing YIN for suppressing the hyperactive YANG to relieve dizziness, high fever, infantile convulsions, epilepsy, etc. for pathogenesis is dialectical to be treated.

The present invention is exactly on the basis of Chinese traditional treatment theory, proposes a kind of pharmaceutical preparation being used for the treatment of cerebral thrombosis, and its therapeutic effect is higher than Western medicine group, and medication is convenient, and have no side effect, drug safety, low price, is worthy of popularization.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of pharmaceutical preparation being used for the treatment of cerebral thrombosis, and its therapeutic effect is higher than Western medicine group, and medication is convenient, and have no side effect, drug safety, low price, is worthy of popularization.

For solving the problems of the technologies described above, the invention provides a kind of pharmaceutical preparation being used for the treatment of cerebral thrombosis, its crude drug comprises Herba Lysimachiae, Pollen Typhae, Rhizoma Alismatis, Semen Persicae, Rhizoma Chuanxiong, Herba Siegesbeckiae, Fructus Crataegi, Hirudo, Fructus Xanthii, Concretio Silicea Bambusae, Semen Coicis, Radix Et Caulis Acanthopanacis Senticosi, the Radix Astragali, Caulis Spatholobi, Lignum Sappan, Radix Salviae Miltiorrhizae, Rhizoma Acori Calami, Semen Euryales, Radix Asparagi, Fructus Trichosanthis, the Radix Angelicae Dahuricae, Exocarpium Citri Grandis, the Cortex Eucommiae, Semen Myristicae, Conyza japonica, Herba Salviae Chinensis, Herba Taxilli, Radix et Rhizoma Rhei Franzenbachii, Radix seu Herba Gei aleppici and Radix Pseudostellariae.

Wherein, in described pharmaceutical preparation, the weight of each crude drug is respectively Herba Lysimachiae 45g ~ 55g, Pollen Typhae 20g ~ 30g, Rhizoma Alismatis 25g ~ 35g, Semen Persicae 30g ~ 40g, Rhizoma Chuanxiong 35g ~ 45g, Herba Siegesbeckiae 20g ~ 30g, Fructus Crataegi 20g ~ 30g, Hirudo 15g ~ 25g, Fructus Xanthii 30g ~ 40g, Concretio Silicea Bambusae 35g ~ 45g, Semen Coicis 25g ~ 35g, Radix Et Caulis Acanthopanacis Senticosi 50g ~ 60g, Radix Astragali 45g ~ 55g, Caulis Spatholobi 30g ~ 40g, Lignum Sappan 30g ~ 40g, Radix Salviae Miltiorrhizae 25g ~ 35g, Rhizoma Acori Calami 20g ~ 30g, Semen Euryales 25g ~ 35g, Radix Asparagi 30g ~ 40g, Fructus Trichosanthis 20g ~ 30g, Radix Angelicae Dahuricae 25g ~ 35g, Exocarpium Citri Grandis 20g ~ 30g, Cortex Eucommiae 30g ~ 40g, Semen Myristicae 25g ~ 35g, Conyza japonica 20g ~ 30g, Herba Salviae Chinensis 20g ~ 30g, Herba Taxilli 25g ~ 35g, Radix et Rhizoma Rhei Franzenbachii 20g ~ 30g, Radix seu Herba Gei aleppici 30g ~ 40g and Radix Pseudostellariae 35g ~ 45g.

Wherein, in described pharmaceutical preparation, the weight of each crude drug is respectively Herba Lysimachiae 48g ~ 52g, Pollen Typhae 23g ~ 27g, Rhizoma Alismatis 28g ~ 32g, Semen Persicae 33g ~ 37g, Rhizoma Chuanxiong 38g ~ 42g, Herba Siegesbeckiae 23g ~ 27g, Fructus Crataegi 23g ~ 27g, Hirudo 18g ~ 22g, Fructus Xanthii 33g ~ 37g, Concretio Silicea Bambusae 38g ~ 42g, Semen Coicis 28g ~ 32g, Radix Et Caulis Acanthopanacis Senticosi 53g ~ 57g, Radix Astragali 48g ~ 52g, Caulis Spatholobi 33g ~ 37g, Lignum Sappan 33g ~ 37g, Radix Salviae Miltiorrhizae 28g ~ 32g, Rhizoma Acori Calami 23g ~ 27g, Semen Euryales 28g ~ 32g, Radix Asparagi 33g ~ 37g, Fructus Trichosanthis 23g ~ 27g, Radix Angelicae Dahuricae 28g ~ 32g, Exocarpium Citri Grandis 23g ~ 27g, Cortex Eucommiae 33g ~ 37g, Semen Myristicae 28g ~ 32g, Conyza japonica 23g ~ 27g, Herba Salviae Chinensis 23g ~ 27g, Herba Taxilli 28g ~ 32g, Radix et Rhizoma Rhei Franzenbachii 23g ~ 27g, Radix seu Herba Gei aleppici 33g ~ 37g and Radix Pseudostellariae 38g ~ 42g.

Wherein, in described pharmaceutical preparation, the weight of each crude drug is respectively Herba Lysimachiae 50 g, Pollen Typhae 25 g, Rhizoma Alismatis 30g, Semen Persicae 35g, Rhizoma Chuanxiong 40g, Herba Siegesbeckiae 25g, Fructus Crataegi 25g, Hirudo 20g, Fructus Xanthii 35g, Concretio Silicea Bambusae 40g, Semen Coicis 30g, Radix Et Caulis Acanthopanacis Senticosi 55g, Radix Astragali 50g, Caulis Spatholobi 35g, Lignum Sappan 35g, Radix Salviae Miltiorrhizae 30g, Rhizoma Acori Calami 25g, Semen Euryales 30g, Radix Asparagi 35g, Fructus Trichosanthis 25g, Radix Angelicae Dahuricae 30g, Exocarpium Citri Grandis 25g, Cortex Eucommiae 35g, Semen Myristicae 30g, Conyza japonica 25g, Herba Salviae Chinensis 25g, Herba Taxilli 30g, Radix et Rhizoma Rhei Franzenbachii 25g, Radix seu Herba Gei aleppici 35g and Radix Pseudostellariae 40g.

Wherein, described pharmaceutical preparation is prepared into injection.

Present invention also offers the preparation method of said medicine preparation, be specially:

The first step, by Pollen Typhae, Semen Persicae, Rhizoma Chuanxiong, Hirudo, Concretio Silicea Bambusae, Radix Et Caulis Acanthopanacis Senticosi, the Radix Astragali, Caulis Spatholobi, Lignum Sappan, Radix Salviae Miltiorrhizae, Semen Euryales, Exocarpium Citri Grandis, the Cortex Eucommiae, Semen Myristicae, Radix et Rhizoma Rhei Franzenbachii, Radix seu Herba Gei aleppici and Radix Pseudostellariae are pulverized respectively, cross 20 mesh sieves, put into blender to stir, mixing, mixed mixture being dissolved in determining alcohol is in the ethanol of 80% ~ 90%, the amount of the ethanol added is 2 ~ 4 times of the mixture quality that this step obtains, reflux, extract, 2 times ~ 4 times, filter, merging filtrate, concentrating under reduced pressure removing ethanol, obtain dry mastic, carry out drying subsequently, pulverize, powder after pulverizing is added the water dissolution relative to its quality 3 ~ 5 times amount, filter, add concentration be 10% salt acid for adjusting pH value be 3 ~ 4, static 2 ~ 4 hours, filter, filtrate alcohol extraction, extract concentrating under reduced pressure becomes dry mastic, dry subsequently, be ground into 50 order ~ 100 object fine powders,

Second step, component under She is pulverized respectively, cross 20 mesh sieves, put into blender to stir, mixing, by mixed mixture, add the water relative to its quality 2 ~ 4 times, decoct 3 ~ 5 hours, decoction liquor is filtered, filtering residue adds the water relative to the mixture quality prepared 2 ~ 4 times again above, decoct 2 ~ 4 hours, decoction liquor is filtered, twice decoction liquor is merged, add concentration be 10% salt acid for adjusting pH value be 3 ~ 4, static 2 ~ 4 hours, filter, filtrate alcohol extraction, extract concentrating under reduced pressure becomes dry mastic, dry subsequently, be ground into 50 order ~ 100 object fine powders,

3rd step, the fine powder mixing first step and second step obtained, gets 200g, add appropriate water for injection, stir 20min ~ 40min, adjust ph to 6.0 ~ 7.0, cold preservation 24 hours at the temperature of 0 DEG C ~ 4 DEG C, with 0.45 μm of membrane filtration, add water for injection to 1000ml, then use 0.45 μm of membrane filtration, fill is in injection bottle, sterilizing 30 minutes at 110 DEG C, obtains injection.

Beneficial effect of the present invention:

The therapeutic effect of pharmaceutical preparation provided by the invention is higher than Western medicine group, and medication is convenient, and have no side effect, drug safety, low price, is worthy of popularization.

Detailed description of the invention

The invention provides a kind of pharmaceutical preparation being used for the treatment of cerebral thrombosis, its crude drug comprises Herba Lysimachiae, Pollen Typhae, Rhizoma Alismatis, Semen Persicae, Rhizoma Chuanxiong, Herba Siegesbeckiae, Fructus Crataegi, Hirudo, Fructus Xanthii, Concretio Silicea Bambusae, Semen Coicis, Radix Et Caulis Acanthopanacis Senticosi, the Radix Astragali, Caulis Spatholobi, Lignum Sappan, Radix Salviae Miltiorrhizae, Rhizoma Acori Calami, Semen Euryales, Radix Asparagi, Fructus Trichosanthis, the Radix Angelicae Dahuricae, Exocarpium Citri Grandis, the Cortex Eucommiae, Semen Myristicae, Conyza japonica, Herba Salviae Chinensis, Herba Taxilli, Radix et Rhizoma Rhei Franzenbachii, Radix seu Herba Gei aleppici and Radix Pseudostellariae.

Further, described pharmaceutical preparation is only made up of above-mentioned raw materials medicine.

In described pharmaceutical preparation, the weight of each crude drug is respectively Herba Lysimachiae 45g ~ 55g, Pollen Typhae 20g ~ 30g, Rhizoma Alismatis 25g ~ 35g, Semen Persicae 30g ~ 40g, Rhizoma Chuanxiong 35g ~ 45g, Herba Siegesbeckiae 20g ~ 30g, Fructus Crataegi 20g ~ 30g, Hirudo 15g ~ 25g, Fructus Xanthii 30g ~ 40g, Concretio Silicea Bambusae 35g ~ 45g, Semen Coicis 25g ~ 35g, Radix Et Caulis Acanthopanacis Senticosi 50g ~ 60g, Radix Astragali 45g ~ 55g, Caulis Spatholobi 30g ~ 40g, Lignum Sappan 30g ~ 40g, Radix Salviae Miltiorrhizae 25g ~ 35g, Rhizoma Acori Calami 20g ~ 30g, Semen Euryales 25g ~ 35g, Radix Asparagi 30g ~ 40g, Fructus Trichosanthis 20g ~ 30g, Radix Angelicae Dahuricae 25g ~ 35g, Exocarpium Citri Grandis 20g ~ 30g, Cortex Eucommiae 30g ~ 40g, Semen Myristicae 25g ~ 35g, Conyza japonica 20g ~ 30g, Herba Salviae Chinensis 20g ~ 30g, Herba Taxilli 25g ~ 35g, Radix et Rhizoma Rhei Franzenbachii 20g ~ 30g, Radix seu Herba Gei aleppici 30g ~ 40g and Radix Pseudostellariae 35g ~ 45g.

Further, in described pharmaceutical preparation, the weight of each crude drug is respectively Herba Lysimachiae 48g ~ 52g, Pollen Typhae 23g ~ 27g, Rhizoma Alismatis 28g ~ 32g, Semen Persicae 33g ~ 37g, Rhizoma Chuanxiong 38g ~ 42g, Herba Siegesbeckiae 23g ~ 27g, Fructus Crataegi 23g ~ 27g, Hirudo 18g ~ 22g, Fructus Xanthii 33g ~ 37g, Concretio Silicea Bambusae 38g ~ 42g, Semen Coicis 28g ~ 32g, Radix Et Caulis Acanthopanacis Senticosi 53g ~ 57g, Radix Astragali 48g ~ 52g, Caulis Spatholobi 33g ~ 37g, Lignum Sappan 33g ~ 37g, Radix Salviae Miltiorrhizae 28g ~ 32g, Rhizoma Acori Calami 23g ~ 27g, Semen Euryales 28g ~ 32g, Radix Asparagi 33g ~ 37g, Fructus Trichosanthis 23g ~ 27g, Radix Angelicae Dahuricae 28g ~ 32g, Exocarpium Citri Grandis 23g ~ 27g, Cortex Eucommiae 33g ~ 37g, Semen Myristicae 28g ~ 32g, Conyza japonica 23g ~ 27g, Herba Salviae Chinensis 23g ~ 27g, Herba Taxilli 28g ~ 32g, Radix et Rhizoma Rhei Franzenbachii 23g ~ 27g, Radix seu Herba Gei aleppici 33g ~ 37g and Radix Pseudostellariae 38g ~ 42g.

Most preferably, in described pharmaceutical preparation, the weight of each crude drug is respectively Herba Lysimachiae 50g, Pollen Typhae 25g, Rhizoma Alismatis 30g, Semen Persicae 35g, Rhizoma Chuanxiong 40g, Herba Siegesbeckiae 25g, Fructus Crataegi 25g, Hirudo 20g, Fructus Xanthii 35g, Concretio Silicea Bambusae 40g, Semen Coicis 30g, Radix Et Caulis Acanthopanacis Senticosi 55g, Radix Astragali 50g, Caulis Spatholobi 35g, Lignum Sappan 35g, Radix Salviae Miltiorrhizae 30g, Rhizoma Acori Calami 25g, Semen Euryales 30g, Radix Asparagi 35g, Fructus Trichosanthis 25g, Radix Angelicae Dahuricae 30g, Exocarpium Citri Grandis 25g, Cortex Eucommiae 35g, Semen Myristicae 30g, Conyza japonica 25g, Herba Salviae Chinensis 25g, Herba Taxilli 30g, Radix et Rhizoma Rhei Franzenbachii 25g, Radix seu Herba Gei aleppici 35g and Radix Pseudostellariae 40g.

The pharmacology of each crude drug is as follows:

Herba Lysimachiae: sweet in the mouth, slightly stringy pulse, cold nature, enters liver, gallbladder, kidney, urinary bladder channel, has effect of clearing away heat-damp and promoting diuresis, Tonglin Paishi, removing toxic substances and promoting subsidence of swelling, cures mainly liver and gall and urinary system calculus; Pyretic stranguria; Oedema due to nephritis; Jaundice due to damp-heat; Sore carbuncle; Venom; The cards such as traumatic injury, are usually used in acute and chronic infectious hepatitis, the treatment of gallbladder wing inflammation and hepatic secretion malfunction.

Pollen Typhae: bitter in the mouth, pungent, warm in nature, returns Liver Channel, has removing blood stasis circulation of qi promoting, effect of inducing menstruation to relieve menalgia, cures mainly the breast side of body and twinges, amenorrhea, lump in the abdomen, rheumatism shoulder arm pain, the cards such as tumbling and swelling.

Rhizoma Alismatis: sweet in the mouth, light, cold in nature, enters kidney, urinary bladder channel, has promoting diuresis to eliminate damp pathogen, purging heat and treating stranguria, the lung that clears away heart-fire, rushes down the effect of kidney fire, is mainly used in insufficiency of the spleen retention of water-damp, the wet hydrosarca of spreading unchecked of water; The tired resistance of the heresy of diseases caused by retention of fluid phlegm-damp, what cause that clear YANG failing to ascend voiced sound do not fall is dizzy; The dysuria of damp invasion of lower energizer, red short puckery pain, and the card such as jaundice due to damp-heat.

Semen Persicae: bitter in the mouth, sweet, property is put down, and GUIXIN, liver, large intestine channel, have blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, effect of relieving cough and asthma, for amenorrhea, dysmenorrhea ， WEIJIA mass in the abdomen, injury from falling down, the cards such as dryness of the intestine constipation.

Rhizoma Chuanxiong: acrid in the mouth, warm in nature, return liver, gallbladder, pericardium channel, have blood-activating and qi-promoting, effect of wind-expelling pain-stopping, cures mainly menoxenia; Amenorrhea dysmenorrhea; The stagnant raw meat pain of the stasis of blood in puerperal; Lump in the abdomen lump; Pain in chest and hypochondrium; Have a headache dizzy; Anemofrigid-damp arthralgia; Traumatic injury; The cards such as ulcer sores.

Herba Siegesbeckiae: latin name SiegesbeckiaeHerba, taste is cold, pungent, bitter, returns Liver Channel, kidney channel, has wind-damp dispelling, sharp joint, effect of removing toxic substances, cures mainly that rheumatic arthralgia, muscles and bones are unable, the card such as soreness of the waist and knees, quadriplegia, hemiplegia, rubella eczema.

Fructus Crataegi: latin name Crataegi Folium, sour in the mouth, property is put down, and returns Liver Channel, has blood circulation promoting and blood stasis dispelling, regulate the flow of vital energy and promote blood circulation, change effect of turbid blood fat reducing, cure mainly qi depression to blood stasis, obstruction of qi in the chest and cardialgia, chest distress, palpitation and amnesia, vertigo and tinnitus, the cards such as hyperlipidemia.

Hirudo: taste becomes, hardship, and property is put down, and enters Liver Channel, there is effect of removing blood stasis, for blood stasis amenorrhea, lump in the abdomen stomachache, blood-retention, traumatic blood stasis had a pain, the treatment of the disease such as carbuncle erysipelas, Hirudo can be eliminated tremulous pulse week and be raised plaque, increases cardiac muscle nutritional blood flow, improves arrhythmia.

Fructus Xanthii: latin name Xanthii Fructus, acrid in the mouth, hardship, warm in nature, return lung meridian, there is the function of the dehumidifying of loose wind, understand things pain-stopping, cure mainly nasal sinusitis; Headche due to wind-cold; Rheumatic arthralgia; Rubella; Eczema; The cards such as scabies.

Concretio Silicea Bambusae: sweet in the mouth, cold in nature, have clear heat and eliminate phlegm, effect of cool heart arresting convulsion, cures mainly calentura coma delirium, and middle wind-phlegm fan in silence, twitch, epilepsy by infantile convulsion.The cards such as phlegm-heat cough.

Semen Coicis: latin name Coicis Semen, sweet in the mouth, light, cold nature, enters lung, spleen, large intestine channel, has invigorating the spleen to arrest diarrhea, diuretic eliminating impediment, and effect of row's skin ulcer pus, curing mainly having loose bowels of wet tired lung stomach; Damp invades the hydrosarca of stain skin, dysuria; The damp and hot numbness hindered in QI and blood passes to and the scorchingly hot card such as lung abscess, acute appendicitis pented up in lung intestinal.

Radix Et Caulis Acanthopanacis Senticosi: be the root of studies on plants of Acanthopanax Miq. in Araliaceae Radix Et Caulis Acanthopanacis Senticosi, rhizome or stem and leaf, latin name Acanthopanacis Senticosi Radix et Rhizoma seu Caulis, acrid in the mouth, hardship, micro-sweet, warm in nature, enter spleen, kidney, heart channel, there is replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, effect of expelling wind and removing dampness, soft for anemofrigid-damp arthralgia, lumbocrural pain, muscles and bones flaccidity, be slow in action, the card such as body weakness with emaciation is weak, traumatic injury, fracture, edema, beriberi, uncontrolled urination are itched.

The Radix Astragali: latin name Astragali Radix, sweet in the mouth, warm in nature, enter spleen, lung meridian, there is tonification spleen soil, elevate a turnable ladder yang-energy, strengthening superficial resistance to stop perspiration, effect of holder skin ulcer granulation promoting, cures mainly the weak anorexia and loose stool that deficiency of both the splenic and pulmonary QI is caused, shortness of breath and palpitation, the visceroptosis of sinking of QI of middle-JIAO, the metrorrhagia of QI failing to control blood is had blood in stool, chronic diarrhea proctoptosis; The spontaneous sweating of exterior deficiency, the cards such as insufficiency of vital energy and blood.

Caulis Spatholobi: latin name Spatholobi Caulis, bitter in the mouth, sweet, warm in nature, enter liver, kidney channel, there is blood vessel dilating, enrich blood and invigorate blood circulation, regulating menstruation, effect of relaxing muscles and tendons and activating QI and blood in the collateral, there is obvious inhibitory action to platelet aggregation, promote animal kidney and the total phosphorus metabolism in uterus, be mainly used in treating the menoxenia that blood deficiency has silt, limbs pain is meciless, the card such as soreness of the waist and knees, pain.

Lignum Sappan: latin name sappanlignum, sweet in the mouth, one-tenth, property is put down, and enters the heart, liver, large intestine channel, has blood circulation promoting and blood stasis dispelling, the effect of reducing swelling and alleviating pain, for blood stasis amenorrhea, dysmenorrhea, the stagnant stomachache of the stasis of blood in puerperal, traumatic injury, the cards such as fracture carbuncle sore tumefacting virus.

Radix Salviae Miltiorrhizae: bitter in the mouth, cold nature, enters the heart, Liver Channel, has promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, and clear away heart-fire relieving restlessness, the effect of nourishing blood to tranquillize the mind, for menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, the cards such as angina pectoris.

Rhizoma Acori Calami: latin name Acori Calami Rhizoma, bitter in the mouth, pungent, warm in nature, have stomach warming, effect of anti-inflammatory analgetic, for mending stomach sun, dyspepsia, food stagnates, diphtheria, the cards such as anthrax.

Semen Euryales: sweet in the mouth, puckery, property is put down, and return spleen, kidney channel, have reinforcing the kindey to control nocturnal emission, effect of spleen reinforcing stopping leak, cures mainly seminal emission, stranguria with turbid discharge, leukorrhagia, incontinence of urine, the cards such as loose stool and diarrhea.

Radix Asparagi: sweet in the mouth, hardship, cold in nature, return lung, kidney channel, there is nourishing YIN to relieve dryness, effect that lung heat clearing is promoted the production of body fluid, cures mainly cough caused by dryness-heat, deficiency of YIN chronic cough, hyperactivity of fire caused by deficiency of YIN, the laryngopharynx swelling and pain of the not solid seminal emission of kidney essense, premature ejaculation and hyperactivity of deficient fire, calentura Tianjin wound is thirsty, and interior-heat is quenched one's thirst the cards such as dryness of the intestine constipation.

Fructus Trichosanthis: sweet in the mouth, micro-hardship, cold in nature, enter lung, stomach, large intestine channel, have removing heat-phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, effect of loosening bowel to relieve constipation, for cough due to lung-heat, the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia, blocked-up chest feeling of fullness, acute mastitis, lung abscess, the cards such as acute appendicitis swells and ache, constipation.

The Radix Angelicae Dahuricae: warm in nature, acrid in the mouth, returns lung, spleen, stomach warp, has the cold expelling that induces sweat, wind-expelling pain-stopping, clearing the nasal passage, dampness leukorrhagia stopping, effect of detumescence and apocenosis, cures mainly headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp is suffered from abdominal pain, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, the cards such as scabies.

Exocarpium Citri Grandis: acrid in the mouth, hardship, warm in nature.Return lung, spleen channel, there is cold expelling, dampness, promoting the circulation of QI, effect of expectorant.For cough due to wind and cold, itching of the throat abundant expectoration, the card such as food stagnation is got sick from drinking too much wine, jailbird is vexed.

The Cortex Eucommiae: sweet in the mouth, micro-pungent, warm in nature, enters liver, kidney channel, has blood pressure lowering, invigorating the liver and kidney, bone and muscle strengthening, the effect of antiabortive gas, for caused by liver and kidney deficiency, card see dizzy, soreness of waist and knee joint, muscles and bones flaccidity are weak; Instability of kidney QI, frequent micturition or urine have She's drop, uncontrolled urination is itched, sexual impotence, anemia of pregnant woman are weak, frequent fetal movement or waist pendant pain; The cards such as chronic joint diseases, bone tuberculosis, dysmenorrhea, dysfunctional uterine bleeding, chronic pelvic inflammatory disease.

Semen Myristicae: latin name Myristicae Semen, acrid in the mouth, hardship, warm in nature, enter spleen, stomach, large intestine channel, there is the effect of warming middle-JIAO astringing intestine to stop diarrhea, promote qi circulation digestion promoting, the card such as not disappear for diarrhea of deficiency type, cold-dysentery, abdominal distention, lack of appetite vomiting, dyspepsia.

Conyza japonica: bitter in the mouth, pungent, cold in nature, have clearing away heat to alleviate pain, effect of dispelling pathogenic wind and eliminating phlegm, cures mainly laryngitis, pneumonia, laryngopharynx swelling and pain, the cards such as tonsillitis.

Herba Salviae Chinensis: the herb of Lamiaceae Salvia plant Salvia chinensis, Latin literary fame Salvia, acrid in the mouth, hardship, cold nature, has blood circulation promoting and blood stasis dispelling, clearing away heat-damp and promoting diuresis, effect of mass dissipating and swelling eliminating, cures mainly dysmenorrhea, damp-heat vaginal discharge, liver cirrhosis, hepatocarcinoma, has blood in stool, jaundice due to damp-heat, rheumatic ostalgia, and traumatic injury wound is swollen waits card.

Herba Taxilli: bitter in the mouth, sweet, property is put down, and enters liver, kidney channel, have the effect of invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, antiabortive unit, for the soreness of waist pain caused by deficiency of the liver and kindey, muscles and bones flaccidity is soft, the foot and knee being feeble, deficiency of the liver and kindey, essence and blood void is lost, the frequent fetal movement of liability to abortion, the cards such as waist abdomen pain.

Radix et Rhizoma Rhei Franzenbachii: latin name Radix et Rhizome Rhei Franzenbachii is the root and rhizome of polygonaceae plant rheum rhabarbarum, bitter in the mouth; Cold in nature, return stomach; Large intestine channel, has removing toxic substances of purging heat; Effect of removing heat from blood clots absorbing, cures mainly jaundice due to damp-heat; Dysentery; Amenorrhea is suffered from abdominal pain; Hematemesis and epistaxis; Traumatic injury stasis of blood pain; Carbuncle furunculosis; Aphthous stomatitis; The cards such as burn and scald.

Radix seu Herba Gei aleppici: latin name Gei Herba, acrid in the mouth, hardship, property is put down, and return liver, spleen, lung meridian, have analgesia, blood pressure lowering, regulating menstruation, effect of expelling wind and removing dampness, cures mainly hypertension, dizziness headache, menoxenia, lower abdominal pain, leucorrhea, infantile convulsion, lumbago, skelalgia of rheumatism; Carbuncle furuncle and phyma poison is controlled in external, the cards such as traumatic injury.

Radix Pseudostellariae: sweet in the mouth, micro-hardship, property is put down, and enters spleen, lung meridian, there is air making-up and spleen enlivening, the effect of the lung moistening and production of body fluid promoting, for the lack of appetite asthenia of deficiency-weakness of spleen-QI, deficiency of stomach-Yin, energy strengthening the spleen gas, nourishing stomach-YIN, for deficiency of the lung cough caused by dryness and cardiopalmus sleeplessness, the deficiency-heat hyperhidrosis of deficiency of vital energy Tianjin wound, energy supplementing QI for promoting the production of body fluid, control deficiency of vital energy xeropulmonary cough, the card such as cardiopalmus sleeplessness, hyperhidrosis of deficiency of both QI and YIN, Radix Pseudostellariae can improve myocardial contraction, stops in Ca2+ and flows with the generation reducing tachy-arrhythmia.

This pharmaceutical preparation has the blood circulation situation improving cerebral thrombus patient, also can play the effects such as anticoagulation, anti-blood viscosity, anti-platelet aggregation simultaneously, and then promote that blood runs freely in vivo, improve the blood supply of brain, can obtain and treat curative effect preferably.

This pharmaceutical preparation provided by the invention can be prepared into according to various regular dosage form, is preferably prepared into injection.

Present invention also offers the preparation method of said medicine preparation, be specially:

The first step, by Pollen Typhae, Semen Persicae, Rhizoma Chuanxiong, Hirudo, Concretio Silicea Bambusae, Radix Et Caulis Acanthopanacis Senticosi, the Radix Astragali, Caulis Spatholobi, Lignum Sappan, Radix Salviae Miltiorrhizae, Semen Euryales, Exocarpium Citri Grandis, the Cortex Eucommiae, Semen Myristicae, Radix et Rhizoma Rhei Franzenbachii, Radix seu Herba Gei aleppici and Radix Pseudostellariae are pulverized respectively, cross 20 mesh sieves, put into blender to stir, mixing, mixed mixture being dissolved in determining alcohol is in the ethanol of 80% ~ 90%, the amount of the ethanol added is 2 ~ 4 times of the mixture quality that this step obtains, reflux, extract, 2 times ~ 4 times, filter, merging filtrate, concentrating under reduced pressure removing ethanol, obtain dry mastic, carry out drying subsequently, pulverize, powder after pulverizing is added the water dissolution relative to its quality 3 ~ 5 times amount, filter, add concentration be 10% salt acid for adjusting pH value be 3 ~ 4, static 2 ~ 4 hours, filter, filtrate alcohol extraction, extract concentrating under reduced pressure becomes dry mastic, dry subsequently, be ground into 50 order ~ 100 object fine powders,

Second step, component under She is pulverized respectively, cross 20 mesh sieves, put into blender to stir, mixing, by mixed mixture, add the water relative to its quality 2 ~ 4 times, decoct 3 ~ 5 hours, decoction liquor is filtered, filtering residue adds the water relative to the mixture quality prepared 2 ~ 4 times again above, decoct 2 ~ 4 hours, decoction liquor is filtered, twice decoction liquor is merged, add concentration be 10% salt acid for adjusting pH value be 3 ~ 4, static 2 ~ 4 hours, filter, filtrate alcohol extraction, extract concentrating under reduced pressure becomes dry mastic, dry subsequently, be ground into 50 order ~ 100 object fine powders,

3rd step, the fine powder mixing first step and second step obtained, gets 200g, add appropriate water for injection, stir 20min ~ 40min, adjust ph to 6.0 ~ 7.0, cold preservation 24 hours at the temperature of 0 DEG C ~ 4 DEG C, with 0.45 μm of membrane filtration, add water for injection to 1000ml, then use 0.45 μm of membrane filtration, fill is in injection bottle, sterilizing 30 minutes at 110 DEG C, obtains injection.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

The preparation of embodiment 1 injection 1

By Pollen Typhae 25g, Semen Persicae 35g, Rhizoma Chuanxiong 40g, Hirudo 20g, Concretio Silicea Bambusae 40g, Radix Et Caulis Acanthopanacis Senticosi 55g, Radix Astragali 50g, Caulis Spatholobi 35g, Lignum Sappan 35g, Radix Salviae Miltiorrhizae 30g, Semen Euryales 30g, Exocarpium Citri Grandis 25g, Cortex Eucommiae 35g, Semen Myristicae 30g, Radix et Rhizoma Rhei Franzenbachii 25g, Radix seu Herba Gei aleppici 35g and Radix Pseudostellariae 40g pulverizes respectively, crosses 20 mesh sieves, puts into blender and stir, mixing, mixed mixture being dissolved in 1.8kg determining alcohol is in the ethanol of 90%, reflux, extract, 3 times, filter, merging filtrate, concentrating under reduced pressure removing ethanol, obtains dry mastic, carry out drying subsequently, pulverize, the powder after pulverizing is added the water dissolution relative to 2.3kg, filter, add concentration be 10% salt acid for adjusting pH value be 4, static 4 hours, filter, filtrate alcohol extraction, extract concentrating under reduced pressure becomes dry mastic, dry, pulverize into 100 object fine powders subsequently, by Herba Lysimachiae 50g, Rhizoma Alismatis 30g, Herba Siegesbeckiae 25g, Fructus Crataegi 25g, Fructus Xanthii 35g, Semen Coicis 30g, Rhizoma Acori Calami 25g, Radix Asparagi 35g, Fructus Trichosanthis 25g, Radix Angelicae Dahuricae 30g, Conyza japonica 25g, Herba Salviae Chinensis 25g, Herba Taxilli 30g pulverizes respectively, crosses 20 mesh sieves, puts into blender and stir, mixing, by mixed mixture, adds the water of 1.2kg, decoct 4 hours, decoction liquor is filtered, and filtering residue adds the water of 1.2kg again, decoct 3 hours, decoction liquor is filtered, and twice decoction liquor is merged, add concentration be 10% salt acid for adjusting pH value be 4, static 4 hours, filter, filtrate alcohol extraction, extract concentrating under reduced pressure becomes dry mastic, dry subsequently, be ground into 100 object fine powders, by the fine powder mixing obtained, get 200g above, add appropriate water for injection, stir 40min, adjust ph to 7.0, cold preservation 24 hours at the temperature of 0 DEG C, with 0.45 μm of membrane filtration, add water for injection to 1000ml, then use 0.45 μm of membrane filtration, fill is in injection bottle, sterilizing 30 minutes at 110 DEG C, obtains injection 1.

The preparation of embodiment 2 injection 2

By Pollen Typhae 23g, Semen Persicae 33g, Rhizoma Chuanxiong 38g, Hirudo 18g, Concretio Silicea Bambusae 38g, Radix Et Caulis Acanthopanacis Senticosi 53g, Radix Astragali 48g, Caulis Spatholobi 33g, Lignum Sappan 33g, Radix Salviae Miltiorrhizae 28g, Semen Euryales 28g, Exocarpium Citri Grandis 23g, Cortex Eucommiae 33g, Semen Myristicae 28g, Radix et Rhizoma Rhei Franzenbachii 23g, Radix seu Herba Gei aleppici 33g and Radix Pseudostellariae 38g pulverizes respectively, crosses 20 mesh sieves, puts into blender and stir, mixing, mixed mixture being dissolved in 1.5kg determining alcohol is in the ethanol of 90%, reflux, extract, 3 times, filter, merging filtrate, concentrating under reduced pressure removing ethanol, obtains dry mastic, carry out drying subsequently, pulverize, the powder after pulverizing is added the water dissolution relative to 2kg, filter, add concentration be 10% salt acid for adjusting pH value be 4, static 4 hours, filter, filtrate alcohol extraction, extract concentrating under reduced pressure becomes dry mastic, dry, pulverize into 100 object fine powders subsequently, by Herba Lysimachiae 48g, Rhizoma Alismatis 28g, Herba Siegesbeckiae 23g, Fructus Crataegi 23g, Fructus Xanthii 33g, Semen Coicis 28g, Rhizoma Acori Calami 23g, Radix Asparagi 33g, Fructus Trichosanthis 23g, Radix Angelicae Dahuricae 28g, Conyza japonica 23g, Herba Salviae Chinensis 23g, Herba Taxilli 28g pulverizes respectively, crosses 20 mesh sieves, puts into blender and stir, mixing, by mixed mixture, adds the water of 1kg, decoct 4 hours, decoction liquor is filtered, and filtering residue adds the water of 1kg again, decoct 3 hours, decoction liquor is filtered, and twice decoction liquor is merged, add concentration be 10% salt acid for adjusting pH value be 4, static 4 hours, filter, filtrate alcohol extraction, extract concentrating under reduced pressure becomes dry mastic, dry subsequently, be ground into 100 object fine powders, by the fine powder mixing obtained, get 200g above, add appropriate water for injection, stir 40min, adjust ph to 7.0, cold preservation 24 hours at the temperature of 0 DEG C, with 0.45 μm of membrane filtration, add water for injection to 1000ml, then use 0.45 μm of membrane filtration, fill is in injection bottle, sterilizing 30 minutes at 110 DEG C, obtains injection 2.

The preparation of embodiment 3 injection 3

By Pollen Typhae 27g, Semen Persicae 37g, Rhizoma Chuanxiong 42g, Hirudo 22g, Concretio Silicea Bambusae 42g, Radix Et Caulis Acanthopanacis Senticosi 57g, Radix Astragali 52g, Caulis Spatholobi 37g, Lignum Sappan 37g, Radix Salviae Miltiorrhizae 32g, Semen Euryales 32g, Exocarpium Citri Grandis 27g, Cortex Eucommiae 37g, Semen Myristicae 32g, Radix et Rhizoma Rhei Franzenbachii 27g, Radix seu Herba Gei aleppici 37g and Radix Pseudostellariae 42g pulverizes respectively, crosses 20 mesh sieves, puts into blender and stir, mixing, mixed mixture being dissolved in 2kg determining alcohol is in the ethanol of 90%, reflux, extract, 3 times, filter, merging filtrate, concentrating under reduced pressure removing ethanol, obtains dry mastic, carry out drying subsequently, pulverize, the powder after pulverizing is added the water dissolution relative to 2.5kg, filter, add concentration be 10% salt acid for adjusting pH value be 4, static 4 hours, filter, filtrate alcohol extraction, extract concentrating under reduced pressure becomes dry mastic, dry, pulverize into 100 object fine powders subsequently, by Herba Lysimachiae 50g, Rhizoma Alismatis 32g, Herba Siegesbeckiae 27g, Fructus Crataegi 27g, Fructus Xanthii 37g, Semen Coicis 32g, Rhizoma Acori Calami 27g, Radix Asparagi 37g, Fructus Trichosanthis 27g, Radix Angelicae Dahuricae 32g, Conyza japonica 27g, Herba Salviae Chinensis 27g, Herba Taxilli 32g pulverizes respectively, crosses 20 mesh sieves, puts into blender and stir, mixing, by mixed mixture, adds the water of 1.5kg, decoct 4 hours, decoction liquor is filtered, and filtering residue adds the water of 1.5kg again, decoct 3 hours, decoction liquor is filtered, and twice decoction liquor is merged, add concentration be 10% salt acid for adjusting pH value be 4, static 4 hours, filter, filtrate alcohol extraction, extract concentrating under reduced pressure becomes dry mastic, dry subsequently, be ground into 100 object fine powders, by the fine powder mixing obtained, get 200g above, add appropriate water for injection, stir 40min, adjust ph to 7.0, cold preservation 24 hours at the temperature of 0 DEG C, with 0.45 μm of membrane filtration, add water for injection to 1000ml, then use 0.45 μm of membrane filtration, fill is in injection bottle, sterilizing 30 minutes at 110 DEG C, obtains injection 3.

The toxicological experiment of embodiment 4 injection 1

1, acute toxicological experiment

The injection 1 prepared through prerun the present invention is because limiting by concentration and volume, and single administration cannot measure LD ₅₀, therefore do maximum tolerance determination, select the route of administration of intending recommending clinical trial, once give mice, observe 7 days with the dose of maximum volume (100ml/kg), 20 mice all none death, have no obvious signs of toxicity, movable normal.Recording injection 1 mouse vein administration maximum tolerated dose prepared by the present invention is 300ml/kg (every 100ml is containing crude drug 20g), according to the weight, and 845 times of the clinical effective dose 71mg/kg every day (70kg) that is equivalent to be grown up.

2, general pharmacology test

To injection 1100ml/kg prepared by the present invention of sobering animal K.M kind injected in mice, observe 7 days, result voluntary activity is normal, Neurotoxicity is without obvious excited or suppression phenomenon, hair is smooth, diet, feces no abnormality seen, illustrate that injection of the present invention all has no side effect to nervous system, cardiovascular system respiratory system of unifying.

3, long term toxicity test: domesticated dog 60, injection group 40, often organize 20, injection 0.2/kg and 1g/kg90 days of the continuous intravenous injection embodiment of the present invention 1 preparation respectively, matched group is not injected, experimental session, and each treated animal has no poisoning symptom, activity, behavior, diet, feces no abnormality seen, body weight increases with matched group close; Within 10 days, measure electrocardiogram, hematology, blood biochemical, urinalysis 25 test items respectively after 45 days and 90 days and drug withdrawal before administration, after administration, result medication two groups is basically identical with matched group; Medication after 90 days and after drug withdrawal 10 days, to heavy dose of 8, middle dosage 6, matched group 6, carries out 12 organ coefficients and 25 histology's microscopies, is showed no exception; Animal behavior no abnormality seen after drug withdrawal, illustrates that injection of the present invention is without savings intoxication.

Injection 1 prepared by the embodiment of the present invention 1 under 0.2g/kg and 1.0g/kg over much dosage (than the large 35-175 of clinical dosage doubly, than the large 20-100 of animal effective dose doubly) to domesticated dog continuous intravenous injection 90 days, observation is continued 10 days after drug withdrawal, experimental session, each treated animal has been showed no poisoning symptom.The activity of animal, behavior, diet, feces have no abnormal changes.Body weight growth pattern close with matched group (P > 0.05).Before in after and when checking for four times after drug withdrawal, medication two groups and matched group are basically identical.Pathological examination, medication is after 90 days and drug withdrawal after 10 days, and check heavy dose of 8 altogether, middle dosage 6, matched group 6,12 organ coefficients and 25 histology's microscopies, be showed no exception.Prompting: liver is likely toxicity target organ.After drug withdrawal, animal behavior has no morbidity phenomenon, and within the 10th day, provocative test result is negative.

Above-mentioned experimental data shows: Chinese medicine injection long term toxicity of the present invention is very little, is very safe.

Embodiment 5 clinical efficacy

Physical data

The cerebral thrombosis case that 193 routine patients accept for medical treatment during being in January, 2010 ~ 2013, the court year January, all meets the cerebrovascular disease standard of Chinese Medical Association's second time cerebrovascular academic conference revision in 1986, and all makes a definite diagnosis through Cranial Computed Tomography; Main manifestations is slurred speech, apathetic expression, drowsiness, headache, dizziness, light coma, central facial palsy, hemianesthesia, the dyskinesia, hemiplegia of limb, aphasia etc.Chinese traditional treatment group 100 example, 53 routine male, 47 routine women, the range of age 42 ~ 55 years old, the course of disease 4 ~ 48 days, completeness paralytic 29 example, paresis person 71 example; WM therapy group 93 example, 49 routine male, 44 routine women, 40 ~ 78 years old age, the course of disease 4 ~ 45 days, completeness paralytic 27 example, paresis person 66 example.The no significant difference (P > 0.05) of two groups of patients in age, sex, the course of disease, neurological functional deficit and complication scores etc.

Method: two groups of patient treatments 2 weeks are a course for the treatment of, all carry out the treatment of 2 courses for the treatment of.

Treatment by Chinese herbs group: Chinese medicine injection 1100m L embodiment 1 prepared adds 5% glucose injection 250m L iv drip, every day 1 time.

WM therapy group: rationally application cerebral thrombosis regular western medicine medicine, cerebrolysin XUESHUANTONG, low molecular dextran and troxerutin row vein instil, and coordinate the method symptomatic treatments such as blood pressure lowering simultaneously.

Treatment curative effect judgment criteria

Using the clinical neurological deficit degree of paralytic as the criteria for classifying, be divided into healing, effective, take a turn for the better, invalid: neural symptom, sign disappear all completely, muscular strength improve reach more than 3 grades, life can take care of oneself completely into cure; Neural symptom, sign majority disappears, and muscular strength improves and reaches more than 2 grades, can independent ambulation, living section can take care of oneself as effective; Neural symptom, sign fraction disappear, and muscular strength raising reaches 1 grade, holds up crutch to stand, and can't take care of oneself for taking a turn for the better; It is invalid that deterioration or death are.

Statistical procedures

Adopt SPSS 11.0 systems soft ware process data, measurement data represents with (x ± s), compares employing one factor analysis of variance between group, and enumeration data adopts χ ²inspection, P < 0.05 has statistical significance for difference.

Result

Each group of therapeutic effect compares, and the results are shown in Table 1.

Table 1 respectively group therapeutic effect compares

Group	n	Cure	Effective	Effectively	Invalid	Total effective rate
							Treatment group	100	43	32	21	4	96.0％
Matched group	93	26	23	29	15	83.9％

As can be seen from Table 1, adopt drug injection provided by the invention in treatment cerebral thrombosis, effect comparatively western medicine group wants obvious preference, P < 0.05.

All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (6)

1. be used for the treatment of a pharmaceutical preparation for cerebral thrombosis, it is characterized in that: crude drug comprises Herba Lysimachiae, Pollen Typhae, Rhizoma Alismatis, Semen Persicae, Rhizoma Chuanxiong, Herba Siegesbeckiae, Fructus Crataegi, Hirudo, Fructus Xanthii, Concretio Silicea Bambusae, Semen Coicis, Radix Et Caulis Acanthopanacis Senticosi, the Radix Astragali, Caulis Spatholobi, Lignum Sappan, Radix Salviae Miltiorrhizae, Rhizoma Acori Calami, Semen Euryales, Radix Asparagi, Fructus Trichosanthis, the Radix Angelicae Dahuricae, Exocarpium Citri Grandis, the Cortex Eucommiae, Semen Myristicae, Conyza japonica, Herba Salviae Chinensis, Herba Taxilli, Radix et Rhizoma Rhei Franzenbachii, Radix seu Herba Gei aleppici and Radix Pseudostellariae.

2. pharmaceutical preparation as claimed in claim 1, it is characterized in that: the weight of each crude drug is respectively Herba Lysimachiae 45g ~ 55g, Pollen Typhae 20g ~ 30g, Rhizoma Alismatis 25g ~ 35g, Semen Persicae 30g ~ 40g, Rhizoma Chuanxiong 35g ~ 45g, Herba Siegesbeckiae 20g ~ 30g, Fructus Crataegi 20g ~ 30g, Hirudo 15g ~ 25g, Fructus Xanthii 30g ~ 40g, Concretio Silicea Bambusae 35g ~ 45g, Semen Coicis 25g ~ 35g, Radix Et Caulis Acanthopanacis Senticosi 50g ~ 60g, Radix Astragali 45g ~ 55g, Caulis Spatholobi 30g ~ 40g, Lignum Sappan 30g ~ 40g, Radix Salviae Miltiorrhizae 25g ~ 35g, Rhizoma Acori Calami 20g ~ 30g, Semen Euryales 25g ~ 35g, Radix Asparagi 30g ~ 40g, Fructus Trichosanthis 20g ~ 30g, Radix Angelicae Dahuricae 25g ~ 35g, Exocarpium Citri Grandis 20g ~ 30g, Cortex Eucommiae 30g ~ 40g, Semen Myristicae 25g ~ 35g, Conyza japonica 20g ~ 30g, Herba Salviae Chinensis 20g ~ 30g, Herba Taxilli 25g ~ 35g, Radix et Rhizoma Rhei Franzenbachii 20g ~ 30g, Radix seu Herba Gei aleppici 30g ~ 40g and Radix Pseudostellariae 35g ~ 45g.

3. pharmaceutical preparation as claimed in claim 1 or 2, it is characterized in that: the weight of each crude drug is respectively Herba Lysimachiae 48g ~ 52g, Pollen Typhae 23g ~ 27g, Rhizoma Alismatis 28g ~ 32g, Semen Persicae 33g ~ 37g, Rhizoma Chuanxiong 38g ~ 42g, Herba Siegesbeckiae 23g ~ 27g, Fructus Crataegi 23g ~ 27g, Hirudo 18g ~ 22g, Fructus Xanthii 33g ~ 37g, Concretio Silicea Bambusae 38g ~ 42g, Semen Coicis 28g ~ 32g, Radix Et Caulis Acanthopanacis Senticosi 53g ~ 57g, Radix Astragali 48g ~ 52g, Caulis Spatholobi 33g ~ 37g, Lignum Sappan 33g ~ 37g, Radix Salviae Miltiorrhizae 28g ~ 32g, Rhizoma Acori Calami 23g ~ 27g, Semen Euryales 28g ~ 32g, Radix Asparagi 33g ~ 37g, Fructus Trichosanthis 23g ~ 27g, Radix Angelicae Dahuricae 28g ~ 32g, Exocarpium Citri Grandis 23g ~ 27g, Cortex Eucommiae 33g ~ 37g, Semen Myristicae 28g ~ 32g, Conyza japonica 23g ~ 27g, Herba Salviae Chinensis 23g ~ 27g, Herba Taxilli 28g ~ 32g, Radix et Rhizoma Rhei Franzenbachii 23g ~ 27g, Radix seu Herba Gei aleppici 33g ~ 37g and Radix Pseudostellariae 38g ~ 42g.

4. the pharmaceutical preparation as described in claims 1 to 3, it is characterized in that: the weight of each crude drug is respectively Herba Lysimachiae 50g, Pollen Typhae 25g, Rhizoma Alismatis 30g, Semen Persicae 35g, Rhizoma Chuanxiong 40g, Herba Siegesbeckiae 25g, Fructus Crataegi 25g, Hirudo 20g, Fructus Xanthii 35g, Concretio Silicea Bambusae 40g, Semen Coicis 30g, Radix Et Caulis Acanthopanacis Senticosi 55g, Radix Astragali 50g, Caulis Spatholobi 35g, Lignum Sappan 35g, Radix Salviae Miltiorrhizae 30g, Rhizoma Acori Calami 25g, Semen Euryales 30g, Radix Asparagi 35g, Fructus Trichosanthis 25g, Radix Angelicae Dahuricae 30g, Exocarpium Citri Grandis 25g, Cortex Eucommiae 35g, Semen Myristicae 30g, Conyza japonica 25g, Herba Salviae Chinensis 25g, Herba Taxilli 30g, Radix et Rhizoma Rhei Franzenbachii 25g, Radix seu Herba Gei aleppici 35g and Radix Pseudostellariae 40g.

5. the pharmaceutical preparation as described in Claims 1-4, is characterized in that: described pharmaceutical preparation is prepared into injection.

6. the preparation method of pharmaceutical preparation described in claim 1 to 5, is characterized in that:

The first step, by Pollen Typhae, Semen Persicae, Rhizoma Chuanxiong, Hirudo, Concretio Silicea Bambusae, Radix Et Caulis Acanthopanacis Senticosi, the Radix Astragali, Caulis Spatholobi, Lignum Sappan, Radix Salviae Miltiorrhizae, Semen Euryales, Exocarpium Citri Grandis, the Cortex Eucommiae, Semen Myristicae, Radix et Rhizoma Rhei Franzenbachii, Radix seu Herba Gei aleppici and Radix Pseudostellariae are pulverized respectively, cross 20 mesh sieves, put into blender to stir, mixing, mixed mixture being dissolved in determining alcohol is in the ethanol of 80% ~ 90%, the amount of the ethanol added is 2 ~ 4 times of the mixture quality that this step obtains, reflux, extract, 2 times ~ 4 times, filter, merging filtrate, concentrating under reduced pressure removing ethanol, obtain dry mastic, carry out drying subsequently, pulverize, powder after pulverizing is added the water dissolution relative to its quality 3 ~ 5 times amount, filter, add concentration be 10% salt acid for adjusting pH value be 3 ~ 4, static 2 ~ 4 hours, filter, filtrate alcohol extraction, extract concentrating under reduced pressure becomes dry mastic, dry subsequently, be ground into 50 order ~ 100 object fine powders,

Second step, component under She is pulverized respectively, cross 20 mesh sieves, put into blender to stir, mixing, by mixed mixture, add the water relative to its quality 2 ~ 4 times, decoct 3 ~ 5 hours, decoction liquor is filtered, filtering residue adds the water relative to the mixture quality prepared 2 ~ 4 times again above, decoct 2 ~ 4 hours, decoction liquor is filtered, twice decoction liquor is merged, add concentration be 10% salt acid for adjusting pH value be 3 ~ 4, static 2 ~ 4 hours, filter, filtrate alcohol extraction, extract concentrating under reduced pressure becomes dry mastic, dry subsequently, be ground into 50 order ~ 100 object fine powders,

3rd step, the fine powder mixing first step and second step obtained, gets 200g, add appropriate water for injection, stir 20min ~ 40min, adjust ph to 6.0 ~ 7.0, cold preservation 24 hours at the temperature of 0 DEG C ~ 4 DEG C, with 0.45 μm of membrane filtration, add water for injection to 1000ml, then use 0.45 μm of membrane filtration, fill is in injection bottle, sterilizing 30 minutes at 110 DEG C, obtains injection.