CN104491411B - Treat the Chinese medicine composition and its Chinese medicine preparation, preparation method and application of stomach trouble - Google Patents
Treat the Chinese medicine composition and its Chinese medicine preparation, preparation method and application of stomach trouble Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
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Abstract
The invention discloses a kind of Chinese medicine composition for treating stomach trouble and its Chinese medicine preparation, preparation method and application, the Chinese medicine composition of the treatment stomach trouble, count in parts by weight, including：2~15 parts of 25~50 parts of sealwort, 20~30 parts of Radix changii, 1~7 part of polygala, 1~7 part of grass-leaved sweetflag, 20~30 parts of hawthorn, 20~30 parts of Poria cocos and dried orange peel.The Chinese medicine composition of the treatment stomach trouble has significant reinforcing spleen to promote digestion and anti-fatigue effect, suitable for symptoms such as abdominal distension, indigestion, spiritlessness and weakness, poor appetite, dizzy palpitaition, insomnia forgetfulness.
Description
Technical field
The present invention relates to the field of Chinese medicines, more particularly to a kind of Chinese medicine composition for treating stomach trouble and its Chinese medicine preparation, system
Preparation Method and application.
Background technology
Theory of traditional Chinese medical science has " taste source of generating QI and blood " one to say.Taste person, the foundation of acquired constitution, control center, transporting the nutrient-fluids to various parts of the body, skin
Blood vessels are rely in this invariably.No matter the epoch prevent, treat diseases caused by external factors and internal injury disease and need not focus on the tune of taste from ancient times to the present
Reason.With the progress and development of society, people's living standard improves constantly, and the food of fatness, sweet, thick and oily is largely taken in, it is difficult to
Digest and assimilate, in addition the reason such as pressure of bad habits and customs and work, easily cause the disease such as stomach trouble of digestive system, table
It is now poor appetite, gasteremphraxis of having a stomachache, indigestion, spiritlessness and weakness, dizzy palpitaition, the symptom such as insomnia forgetfulness, brings pole
Big pain.So the medicine of exploitation treatment stomach trouble has very important meaning.
The content of the invention
Based on this, it is necessary to provide a kind of Chinese medicine composition and its Chinese medicine system of the treatment stomach trouble with reinforcing spleen to promote digestion effect
Agent, preparation method and application.
A kind of Chinese medicine composition for treating stomach trouble, is counted in parts by weight, including：25~50 parts of sealwort, Radix changii 20~30
2~15 parts of part, 1~7 part of polygala, 1~7 part of grass-leaved sweetflag, 20~30 parts of hawthorn, 20~30 parts of Poria cocos and dried orange peel.
In one of the embodiments, count in parts by weight, including：32~50 parts of sealwort, 23~30 parts of Radix changii, polygala
5~15 parts of 1~5 part, 2~7 parts of grass-leaved sweetflag, 23~30 parts of hawthorn, 23~30 parts of Poria cocos and dried orange peel.
In one of the embodiments, count in parts by weight, including：32~40 parts of sealwort, 23~27 parts of Radix changii, polygala
5~10 parts of 3~5 parts, 2~4 parts of grass-leaved sweetflag, 23~27 parts of hawthorn, 23~27 parts of Poria cocos and dried orange peel.
A kind of Chinese medicine composition for treating stomach trouble, is counted in parts by weight, is mainly prepared by the raw material of following weight parts：
25~50 parts of sealwort, 20~30 parts of Radix changii, 1~7 part of polygala, 1~7 part of grass-leaved sweetflag, 20~30 parts of hawthorn, 20~30 parts of Poria cocos
With 2~15 parts of dried orange peel.
The preparation method of the Chinese medicine composition of above-mentioned treatment stomach trouble, comprises the following steps：
By the sealwort of above-mentioned parts by weight, Radix changii, polygala, grass-leaved sweetflag, hawthorn, Poria cocos and dried orange peel solvent extraction, obtain
The Chinese medicine composition of the treatment stomach trouble.
In one of the embodiments, the solvent is selected from least one of water and ethanol.
In one of the embodiments, by the sealwort of above-mentioned parts by weight, Radix changii, polygala, grass-leaved sweetflag, hawthorn, Poria cocos and
Dried orange peel extracts, and filtering, obtains filtrate, that is, obtains the Chinese medicine composition of the treatment stomach trouble.
Application of the Chinese medicine composition of above-mentioned treatment stomach trouble in the medicine for preparing treatment stomach trouble.
A kind of Chinese medicine preparation for treating stomach trouble, on Chinese medicine composition and medicine comprising above-mentioned treatment stomach trouble or health food
Upper acceptable auxiliary material.
In one of the embodiments, the formulation of the Chinese medicine preparation of the treatment stomach trouble is：Oral liquid, tablet, capsule, ball
Agent, granule, powder, decoction or paste.
The Chinese medicine composition of present invention treatment stomach trouble is based on theory of traditional Chinese medical science, with reference to clinical practice, from traditional Chinese medicine material
What is filtered out in treasure-house is a series of with reinforcing spleen to promote digestion, dispersing stagnated hepatoqi, tranquilizing soporific, anticonvulsion and inducing resuscitation intelligence development Chinese medicine.
Wherein, sealwort cures mainly insufficiency of the spleen weak, few dry of food and had a delicate constitution；Radix changii has yin-nourishing and stomach, moistening lung for removing phlegm, flat liver removing toxic substances
Function；Polygala, there is the effect of tranquilizing the mind, be mainly used in confused and worried, the treatment of the disease such as insomnia forgetfulness；Grass-leaved sweetflag, centering
Pivot nervous system plays the role of tranquilizing soporific, anticonvulsion, inducing resuscitation intelligence development, qi-regulating, spiritlessness and weakness, poor appetite, dizzy palpitaition, loses
The symptom such as sleep forgetful；Hawthorn is the good medicine of spleen benefiting and stimulating the appetite, relieving dyspepsia, phlegm reduction of blood circulation promoting；Poria cocos has clearing damp and promoting diuresis, invigorating the spleen calming heart
It is confused and worried for spleen eating less etc. function, insomnia of palpitating with fear etc.；Dried orange peel has regulating qi-flowing for strengthening spleen, eliminating dampness and eliminating phlegm function, is used for
Abdominal fullness and distention, deficiency of food vomiting and diarrhoea etc..The drug component of the Chinese medicine composition of present invention treatment stomach trouble is being made with phase through dialectical compatibility
It is auxiliary to coordinate, there is synergy, play reinforcing spleen to promote digestion, dispersing stagnated hepatoqi, tranquilizing soporific, anticonvulsion and inducing resuscitation intelligence development and other effects altogether, have
There are significant reinforcing spleen to promote digestion and anti-fatigue effect, suitable for abdominal distension, indigestion, spiritlessness and weakness, lose the appetite, dizzy palpitaition,
The symptoms such as insomnia forgetfulness.
Embodiment
For the ease of understanding the present invention, the present invention is described more fully below, and gives the preferable of the present invention
Embodiment.But the present invention can realize in many different forms, however it is not limited to embodiment described herein.Phase
Instead, there is provided the purpose of these embodiments is to make the understanding more thorough and comprehensive to the disclosure.
Unless otherwise defined, all of technologies and scientific terms used here by the article is with belonging to technical field of the invention
The implication that technical staff is generally understood that is identical.Term used in the description of the invention herein is intended merely to description tool
The purpose of the embodiment of body, it is not intended that in the limitation present invention.Term as used herein " and/or " include one or more phases
The arbitrary and all combination of the Listed Items of pass.
A kind of Chinese medicine composition for treating stomach trouble, is counted in parts by weight, including：25~50 parts of sealwort, Radix changii 20~30
2~15 parts of part, 1~7 part of polygala, 1~7 part of grass-leaved sweetflag, 20~30 parts of hawthorn, 20~30 parts of Poria cocos and dried orange peel.
Preferably, 32~50 parts of sealwort, 23~30 parts of Radix changii, 1~5 part of polygala, 2~7 parts of grass-leaved sweetflag, hawthorn 23~30
5~15 parts of part, 23~30 parts of Poria cocos and dried orange peel.
It is furthermore preferred that 32~40 parts of sealwort, 23~27 parts of Radix changii, 3~5 parts of polygala, 2~4 parts of grass-leaved sweetflag, hawthorn 23~
5~10 parts of 27 parts, 23~27 parts of Poria cocos and dried orange peel.
Preferably, when in use, dried orange peel is chosen for the Chinese medicine composition of above-mentioned treatment stomach trouble, removes impurity and mud
Sand, and it is cut into the thread of 1~2cm by clean dried orange peel has been selected.By sealwort, Radix changii, polygala, grass-leaved sweetflag, hawthorn, Poria cocos and
Dried orange peel crushes, and crosses 100 mesh sieves.
Preferably, the Chinese medicine composition of above-mentioned treatment stomach trouble when in use, by sealwort, Radix changii, polygala, grass-leaved sweetflag, mountain
Short, bristly hair or beard, Poria cocos and dried orange peel water or/and ethanol extraction.Preferably, the Chinese medicine composition of above-mentioned treatment stomach trouble when in use, by Huang
Essence, Radix changii, polygala, grass-leaved sweetflag, hawthorn, Poria cocos and dried orange peel water boiling and extraction.
The Chinese medicine composition of present invention treatment stomach trouble is based on theory of traditional Chinese medical science, with reference to clinical practice, from traditional Chinese medicine material
What is filtered out in treasure-house is a series of with reinforcing spleen to promote digestion, dispersing stagnated hepatoqi, tranquilizing soporific, anticonvulsion and inducing resuscitation intelligence development Chinese medicine.
Wherein, sealwort cures mainly insufficiency of the spleen weak, few dry of food and had a delicate constitution；Radix changii has yin-nourishing and stomach, moistening lung for removing phlegm, flat liver removing toxic substances
Function；Polygala, there is the effect of tranquilizing the mind, be mainly used in confused and worried, the treatment of the disease such as insomnia forgetfulness；Grass-leaved sweetflag, centering
Pivot nervous system plays the role of tranquilizing soporific, anticonvulsion, inducing resuscitation intelligence development, qi-regulating, spiritlessness and weakness, poor appetite, dizzy palpitaition, loses
The symptom such as sleep forgetful；Hawthorn is the good medicine of spleen benefiting and stimulating the appetite, relieving dyspepsia, phlegm reduction of blood circulation promoting；Poria cocos has clearing damp and promoting diuresis, invigorating the spleen calming heart
It is confused and worried for spleen eating less etc. function, insomnia of palpitating with fear etc.；Dried orange peel has regulating qi-flowing for strengthening spleen, eliminating dampness and eliminating phlegm function, is used for
Abdominal fullness and distention, deficiency of food vomiting and diarrhoea etc..The drug component of the Chinese medicine composition of present invention treatment stomach trouble is being made with phase through dialectical compatibility
It is auxiliary to coordinate, there is synergy, play reinforcing spleen to promote digestion, dispersing stagnated hepatoqi, tranquilizing soporific, anticonvulsion and inducing resuscitation intelligence development and other effects altogether, have
There are significant reinforcing spleen to promote digestion and anti-fatigue effect, suitable for abdominal distension, indigestion, spiritlessness and weakness, lose the appetite, dizzy palpitaition,
The symptoms such as insomnia forgetfulness.
It is appreciated that the preparation method of the Chinese medicine composition of above-mentioned treatment stomach trouble, can be that blending crushes.
The Chinese medicine composition of the treatment stomach trouble of another embodiment, is counted in parts by weight, mainly by the original of following weight parts
Material is prepared：25~50 parts of sealwort, 20~30 parts of Radix changii, 1~7 part of polygala, 1~7 part of grass-leaved sweetflag, 20~30 parts of hawthorn,
2~15 parts of 20~30 parts of Poria cocos and dried orange peel.
The preparation method of the Chinese medicine composition of above-mentioned treatment stomach trouble, comprises the following steps：By the sealwort of above-mentioned parts by weight, bright
Radix Codonopsis, polygala, grass-leaved sweetflag, hawthorn, Poria cocos and dried orange peel solvent extraction, the Chinese medicine composition for the stomach trouble that obtains medical treatment.
Especially, before the extraction step, dried orange peel is chosen, removes impurity and silt, and it is clean by having selected
Dried orange peel is cut into the thread of 1~2cm.Sealwort, Radix changii, polygala, grass-leaved sweetflag, hawthorn, Poria cocos and dried orange peel are crushed, cross 100 mesh sieves.
Especially, solvent is selected from least one of water and ethanol.The method of extraction is water boiling and extraction method, alcohol dipping
Extraction method or ethanol percolation extraction method.
Especially, the sealwort of above-mentioned parts by weight, Radix changii, polygala, grass-leaved sweetflag, hawthorn, Poria cocos and dried orange peel are carried with solvent
Take, filtrate retained after filtering, you can.
Especially, step by step arithmetic twice is taken.Extract for the first time, the first filtrate and the first filter residue are obtained, by the first filter residue
Carry out second to extract, obtain the second filtrate and the second filter residue, merge the first filtrate and the second filtrate.Preferably, solvent
Using water, the method for extraction is water boiling and extraction method.
Extract for the first time：The amount for adding water is total matter of sealwort, Radix changii, polygala, grass-leaved sweetflag, hawthorn, Poria cocos and dried orange peel
6~10 times of amount, the time of extraction clocks since boiling water, is 0.5~2 hour.Preferably, add the amount of water for sealwort,
Radix changii, polygala, grass-leaved sweetflag, hawthorn, 8 times of gross mass of Poria cocos and dried orange peel, the time of extraction clocks since boiling water, is
1 hour.
Second of extraction：The amount for adding water is total matter of sealwort, Radix changii, polygala, grass-leaved sweetflag, hawthorn, Poria cocos and dried orange peel
4~8 times of amount, the time of extraction clocks since boiling water, is 0.5~2 hour.Preferably, the amount of water is added as sealwort, bright
Radix Codonopsis, polygala, grass-leaved sweetflag, hawthorn, 6 times of gross mass of Poria cocos and dried orange peel, the time of extraction clocks since boiling water, is 1
Hour.It is appreciated that second of extraction can omit, using once extraction.
Especially, the sealwort of above-mentioned parts by weight, Radix changii, polygala, grass-leaved sweetflag, hawthorn, Poria cocos and dried orange peel are carried with solvent
Take, filtrate is retained after filtering, and filtrate is concentrated.
The step of above-mentioned filtrate is concentrated be specially：Filtrate is concentrated to give concentrate, to concentrate proportion for 1.1~
1.2 (90 DEG C measure), continue will in concentrate add ethanol sedimentation, obtain supernatant, by supernatant concentration to proportion be 1.1~
1.2 (90 DEG C measure).
Preferably, the volume ratio of ethanol of the concentrate with adding is 2~5：5~8, in the mixture for making concentrate and ethanol
Ethanol percentage by volume is 50%~80%.It is furthermore preferred that concentrate is 3 with the ethanol volume ratio added:7, make concentrate with
Ethanol percentage by volume reaches 70% in the mixture of ethanol.Using most of compositions such as alkaloid salt in the plants such as medicinal material,
Glucoside, organic acid, amino acid, polysaccharide etc. be soluble in water and alcohol in characteristic, ethanol sedimentation is continuously added after filtrate is concentrated,
Remove insoluble matter.It is appreciated that will can be omitted the step of ethanol sedimentation is added in concentrate, filtrate is concentrated to give concentration
Thing to proportion is 1.1~1.2 (90 DEG C measure).
The preparation method of the Chinese medicine composition of above-mentioned treatment stomach trouble, method is simple to operation, and take full advantage of raw material has
Composition is imitated, has maximally utilised raw material, the Chinese medicine composition being prepared has significant reinforcing spleen to promote digestion and antifatigue work(
Effect, and is applied to abdominal distension, indigestion, spiritlessness and weakness, loses the appetite, dizzy palpitaition, the symptom such as insomnia forgetfulness.
Application of the Chinese medicine composition of above-mentioned treatment stomach trouble in the medicine for preparing treatment stomach trouble.
A kind of Chinese medicine preparation for treating stomach trouble, on Chinese medicine composition and medicine comprising above-mentioned treatment stomach trouble or health food
Upper acceptable auxiliary material.
In general, auxiliary material can be water, Steviosin, sorbierite, sodium citrate, sodium benzoate and honey etc..
Especially, the formulation of the Chinese medicine preparation of the treatment stomach trouble is：Oral liquid, tablet, capsule, pill, granule, dissipate
Agent, decoction or paste.
It is specific embodiment below.
Embodiment 1
The present embodiment treats the Chinese medicine composition of stomach trouble, counts in parts by weight, is mainly prepared by the raw material of following weight parts
Form：
10 parts of 32 parts of sealwort, 25 parts of Radix changii, 4 parts of polygala, 3 parts of grass-leaved sweetflag, 27 parts of hawthorn, 27 parts of Poria cocos and dried orange peel.
The preparation method of the Chinese medicine composition of above-mentioned treatment stomach trouble, comprises the following steps：
Sealwort, Radix changii, polygala, grass-leaved sweetflag, hawthorn, Poria cocos and dried orange peel are merged, is extracted with water, is taken and divide twice
Step extraction, for the first time extraction add 8 times of raw material gross mass amount water, are heated to seething with excitement, and decoct 1h, filtering, obtain the first filtrate and
First filter residue；6 times of amount water that raw material gross mass is added in the first filter residue are extracted in for the second time, are heated to seething with excitement, are decocted 1h, mistake
Filter, the second filtrate is obtained, merge the first filtrate and the second filtrate.Filtrate is concentrated to give concentrate, the proportion to concentrate is 1.1
~1.2 (90 DEG C measure), continuously add absolute ethyl alcohol sedimentation, and concentrate is 5 with the volume ratio for adding ethanol：5, obtain supernatant
Liquid, it is 1.1~1.2 (90 DEG C measure) by supernatant concentration to proportion, you can.
Embodiment 2
The present embodiment treats the Chinese medicine composition of stomach trouble, counts in parts by weight, is mainly prepared by the raw material of following weight parts
Form：
12 parts of 27 parts of sealwort, 23 parts of Radix changii, 5 parts of polygala, 5 parts of grass-leaved sweetflag, 23 parts of hawthorn, 28 parts of Poria cocos and dried orange peel.
The preparation method of the Chinese medicine composition of above-mentioned treatment stomach trouble, comprises the following steps：
Sealwort, Radix changii, polygala, grass-leaved sweetflag, hawthorn, Poria cocos and dried orange peel are merged, is extracted with water, is taken and divide twice
Step extraction, for the first time extraction add 10 times of raw material gross mass amount water, are heated to seething with excitement, and decoct 2h, filtering, obtain the first filtrate and
First filter residue；4 times of amount water that raw material gross mass is added in the first filter residue are extracted in for the second time, are heated to seething with excitement, are decocted 2h, mistake
Filter, the second filtrate is obtained, merge the first filtrate and the second filtrate.Filtrate is concentrated to give concentrate, the proportion to concentrate is 1.1
~1.2 (90 DEG C measure), continuously add absolute ethyl alcohol sedimentation, and concentrate is 3 with the volume ratio for adding ethanol：7, obtain supernatant
Liquid, it is 1.1~1.2 (90 DEG C measure) by supernatant concentration to proportion, you can.
Embodiment 3
The present embodiment treats the Chinese medicine composition of stomach trouble, counts in parts by weight, is mainly prepared by the raw material of following weight parts
Form：
5 parts of 40 parts of sealwort, 27 parts of Radix changii, 3 parts of polygala, 7 parts of grass-leaved sweetflag, 28 parts of hawthorn, 23 parts of Poria cocos and dried orange peel.
The preparation method of the Chinese medicine composition of above-mentioned treatment stomach trouble, comprises the following steps：
Sealwort, Radix changii, polygala, grass-leaved sweetflag, hawthorn, Poria cocos and dried orange peel are merged, is extracted with water, is taken and divide twice
Step extraction, for the first time extraction add 6 times of amount water of raw material gross mass, are heated to seething with excitement, decoct 0.5h, filtering, obtain the first filtrate
With the first filter residue；8 times of amount water that raw material gross mass is added in the first filter residue are extracted in for the second time, are heated to seething with excitement, are decocted 0.5h,
Filtering, the second filtrate is obtained, merge the first filtrate and the second filtrate.Filtrate is concentrated to give concentrate, the proportion to concentrate is
1.1~1.2 (90 DEG C measure), continuously add absolute ethyl alcohol sedimentation, and concentrate is 2 with the volume ratio for adding ethanol：8, obtain
Clear liquid, it is 1.1~1.2 (90 DEG C measure) by supernatant concentration to proportion, you can.
Embodiment 4
The present embodiment treats the Chinese medicine composition of stomach trouble, counts in parts by weight, is mainly prepared by the raw material of following weight parts
Form：
15 parts of 50 parts of sealwort, 30 parts of Radix changii, 1 part of polygala, 2 parts of grass-leaved sweetflag, 30 parts of hawthorn, 30 parts of Poria cocos and dried orange peel.
The preparation method of the Chinese medicine composition of above-mentioned treatment stomach trouble, comprises the following steps：
By sealwort, Radix changii, polygala, grass-leaved sweetflag, hawthorn, Poria cocos and dried orange peel crush, cross 100 mesh sieves, add water 100mL and
Honey 40g, softwood processed, pill, dry, select ball, capping, you can.
Embodiment 5
The present embodiment treats the Chinese medicine composition of stomach trouble, counts in parts by weight, is mainly prepared by the raw material of following weight parts
Form：
2 parts of 25 parts of sealwort, 20 parts of Radix changii, 7 parts of polygala, 1 part of grass-leaved sweetflag, 20 parts of hawthorn, 20 parts of Poria cocos and dried orange peel.
The preparation method of the Chinese medicine composition of above-mentioned treatment stomach trouble, comprises the following steps：
Sealwort, Radix changii, polygala, grass-leaved sweetflag, hawthorn, Poria cocos and dried orange peel are crushed, 100 mesh sieves is crossed, is extracted with water,
8 times of amount water of raw material gross mass are added, is heated to seething with excitement, decocts 1h, filtering, obtain filtrate.Filtrate is concentrated to give concentrate, extremely
The proportion of concentrate is 1.1~1.2 (90 DEG C measure), continuously adds absolute ethyl alcohol sedimentation, concentrate and the volume for adding ethanol
Than for 3：7, supernatant is obtained, is 1.1~1.2 (90 DEG C measure) by supernatant concentration to proportion, you can.
Pharmacodynamic test of active extract data：
First, experiment purpose
Pharmacological experiment study is carried out to the reinforcing spleen to promote digestion and fatigue-resisting function of the Chinese medicine composition of present invention treatment stomach trouble,
Observe the power of its pharmacological action.
Test method：The embodiment of the present invention 1 treats influence of the Chinese medicine composition to mouse reinforcing spleen to promote digestion of stomach trouble and to small
The antifatigue effect of mouse.
2nd, to the influence of mouse reinforcing spleen to promote digestion
Experimental method
Kunming mouse 40, male and female half and half, 20~25g of body weight, fasting 12h, free water before experiment.It is randomly divided into 4
Group, every group 10.This experiment is divided into experimental group and control group, wherein, experimental group is divided into low dose group 0.5g/kg, middle dose group
1g/kg, tri- groups of high dose group 2g/kg.Control group is normally fed.Experimental group successive administration 10 days, one time a day, after last dose
Fasting 16h (can't help water), and every mouse stomach gives dislocation execution mouse in place's after 0.1% methyl orange solution 0.2mL, 30min, rapidly
Abdomen is opened, stomach is won and is placed in beaker, 10ml water is added, cuts off coat of the stomach, stomach is fully washed in water, uses sodium bicarbonate solution
PH value is adjusted to 6~6.5, centrifuge tube is poured into, 4min is centrifuged with 5000r/min, supernatant is poured out, with spectrophotometer in wavelength
The absorbance of solution is determined under 420nm, as remaining methyl orange amount in stomach, is averaged.Methyl orange Stomach residue rate (%)=stomach
Methyl orange absorbance/radix methyl orange absorbance × 100% (after shaking up survey by 0.1% methyl orange 0.2mL additions 10mL distilled water
Its absorbance is measured as radix methyl orange absorbance).
Experimental result is shown in Table 1：
Table 1
The result of table 1 shows：The Chinese medicine composition of present invention treatment stomach trouble substantially reduces methyl orange in experimental mice stomach
Residual rate, illustrate that the Chinese medicine composition of present invention treatment stomach trouble effectively promotes gastric emptying, have very for gasteremphraxis, indigestion
Good effect, has significant reinforcing spleen to promote digestion effect.
3rd, to the effect of mouse anti-reflecting fatigue
Experimental method
Kunming mouse 40, male and female half and half, 20~25g of body weight, fasting 12h, free water before experiment.It is randomly divided into 4
Group, every group 10.This experiment is divided into experimental group and control group, wherein, experimental group is divided into low dose group 0.5g/kg, middle dose group
1g/kg, tri- groups of high dose group 2g/kg.Control group is normally fed.Experimental group successive administration 10 days, one time a day, last dose 1h
Afterwards, mouse tail root beam 2g lead, mouse being placed in glass jar went swimming, depth of water 20cm respectively, water temperature is kept for 25 ± 0.5 DEG C,
Record swimming time, when mouse head submerged 10s can not the person of emerging be muscle power exhaust, timing at once be mouse trip
Swim the time, calculate average value.
Experimental result is shown in Table 2：
Table 2
The result of table 2 shows：The Chinese medicine composition of present invention treatment stomach trouble is obviously prolonged the walking weight load of mouse, says
The Chinese medicine composition of bright present invention treatment stomach trouble serves the effect of inducing resuscitation intelligence development, has significant anti-fatigue effect.
Embodiment described above only expresses the several embodiments of the present invention, and its description is more specific and detailed, but simultaneously
Therefore the limitation to the scope of the claims of the present invention can not be interpreted as.It should be pointed out that for one of ordinary skill in the art
For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the guarantor of the present invention
Protect scope.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (1)
1. a kind of preparation method for the Chinese medicine composition for treating stomach trouble, it is characterised in that comprise the following steps：
Meter provides the following raw material in parts by weight：25~50 parts of sealwort, 20~30 parts of Radix changii, 1~7 part of polygala, grass-leaved sweetflag 1~
2~15 parts of 7 parts, 20~30 parts of hawthorn, 20~30 parts of Poria cocos and dried orange peel；
The sealwort of above-mentioned parts by weight, Radix changii, polygala, grass-leaved sweetflag, hawthorn, Poria cocos and dried orange peel are used with solvent and carried step by step twice
Take, extraction for the first time obtains the first filtrate and the first filter residue, and first filter residue is carried out into second extracts, and obtains the second filtrate
With the second filter residue, after merging first filtrate and second filtrate, be concentrated into 90 DEG C of proportions for measuring concentrate for 1.1~
1.2, add ethanol sedimentation, obtain supernatant, concentrate the supernatant to 90 DEG C of proportions for measuring the supernatant be 1.1~
1.2, obtain the Chinese medicine composition of the treatment stomach trouble；Wherein, the solvent is water；Extract for the first time：The amount for adding water is Huang
Essence, Radix changii, polygala, grass-leaved sweetflag, hawthorn, 6~10 times of gross mass of Poria cocos and dried orange peel, the time of extraction is since boiling water
Clock, be 0.5~2 hour；Second of extraction：Add water amount for sealwort, Radix changii, polygala, grass-leaved sweetflag, hawthorn, Poria cocos and
4~8 times of the gross mass of dried orange peel, the time of extraction clocks since boiling water, is 0.5~2 hour.
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