CN102613555A - Maca powder and ginseng composition and preparation method thereof - Google Patents
Maca powder and ginseng composition and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a maca powder and ginseng composition and a preparation method thereof. The maca powder and ginseng composition is prepared from the following raw materials in part by weight: 2.5 to 8.5 parts of ginseng extract, 10 to 30 parts of integripetal rhodiola herb extract, 10 to 30 parts of epimedium herb extract, 6 to 18 parts of medlar extract and 75 to 250 parts of maca powder by sieving and uniformly mixing. The maca powder and ginseng composition is prepared from natural raw materials, is safe to eat, has an obvious effect, and can be prepared into Chinese medicinal health foods having effects of enhancing immunity and relieving physical fatigue.
Description
Technical field
The present invention relates to field of health care food, the concrete a kind of pueraria root powder ginseng composition and preparation method thereof that relates to.
Background technology
Fatigue, pain, insomnia (sleep-disorder), constipation are the four major problems of inferior health, and confirmed fatigue occupies first of the four big subject matters of inferior health, and it is big that it influences the crowd, degree seriously obvious to all.Chronic fatigue syndrome belongs to categories such as the traditional Chinese medical science " overstrain, consumptive disease ", " being insomnia ", " palpitaition ", " strongly fragrant disease ", thinks that the health of human body relies equilibrium between yin and yang, the coordination of internal organs qi and blood entirely." overstrain " be meant overtired due to, comprise " body labor ", " impairment of the heart caused by ocerstrain ", " sexual strain " etc., cause viscera, qi and blood dysequilibrium, essence, gas, refreshing impaired.Reason be bother excessively, feelings will is smooth, native endowment is not enough or serious disease after lose due to the conditioning, its cause of disease can be summarized as the internal organs loss, negative and positive of qi and blood is not enough, depression and stagnation of QI.Card belongs to asthenia in origin and asthenia in superficiality, and is empty not enough at negative and positive of qi and blood, tangible depression and stagnation of QI.Adopt beneficial gas, nourish blood, enriching yin, Wen Yang to be to mend its void; Difference according to depression and stagnation of QI adopts soothing the liver sharp gas respectively, the agent of invigorate blood circulation sharp gas and the sharp gas of stomach to be to dredge the stasis of smooth mechanism of qi.For different people and different situations; Fatigue can show on the different at different position and different; Except that malaise; Have that four limbs are idle, lassitude in loin and legs, lassitude, asthenopia, impotence and premature ejaculation, slow in reacting or the like, fatigue both can appear on one's body the healthy subjects, also was the some symptoms that occur in a lot of diseases.
Genseng is well-known famous and precious traditional tonic medicine, just puts down in writing genseng in the Shennong's Herbal before more than 2,000 years and has the effect of " tonifying five zang organs is pacified spirit, decides soul, and only palpitation with fear removes perverse trend, makes eye bright, and intelligence development is happily obeyed to make light of one's life by commiting suicide for a long time and prolonged life ".Genseng has obvious effect (Zhang Xiaofen etc., the anti-sports fatigue experimental study of effect of genseng, traditional Chinese medicine journal, the 29th page of the 6th phase of nineteen ninety-five) to the antifatigue that improves mouse, anti-anoxic, the anti-aspect such as haematochrome increasing that stress reach.
Rhodiola root is top grade in the medicine, and the sachalin rhodiola rhizome beneficial gas of making light of one's life by commiting suicide is taken in Shennong's Herbal record, do not prolong life always, and nontoxic many clothes, clothes are not hurted sb.'s feelings for a long time.Can kidney tonifying, regulate the flow of vital energy and nourish blood, it is weak, uncomfortable in chest etc. to cure mainly the whole body; Also have promoting blood circulation and hemostasis, removing heat from the lung to relieve cough, analgesic, and end the effect under the band.Rhodiola root possesses the effect (" modern practical book on Chinese herbal medicine ") of good maincenter inhibition, antifatigue, cardiac stimulant, anti-inflammatory, the rising of inhibition blood sugar, anti-peroxidation and resisting microwave radiation.
Barrenwort contains icariine (icariin), icariside (icarisoside) etc., but tonifying kidney and strengthening yang, strengthening the bones and muscles.Research shows that epimedium brevicornum polysaccharide has the effect of enhancing body immunologic function, and epimedium brevicornum polysaccharide had both increased spleen antibody-producting cell number through the influence to the spleen antibody-producting cell, promotes each thick liquid cell to produce antibody again.Barrenwort contains a large amount of flavones ingredients; It has fatigue proof effect the experiment proof, shows obvious synergistic effect (Zou Yan etc., the experimental study of barrenwort, the anti-anoxic of genseng, endurance and antioxidation during with the genseng coupling; Zunyi Medical College's journal, the 24th the 1st phase of volume of calendar year 2001).
The fruit of Chinese wolfberry is nourishing liver and kidney, benefiting shrewd head.The Compendium of Material Medica record: " matrimony vine, kidney-tonifying sperm-generating, nourishing the liver ... make eye bright and calm the nerves make us long-lived." modern age pharmacological evaluation show: the fruit of Chinese wolfberry has the enhancing body immunologic function, suppresses tumour, and is hypoglycemic, reducing blood lipid, functions such as antifatigue.
Agate coffee (MACA, latin name Lepidium meyenii Walp) is a Cruciferae separate row Vegetable spp plant, is the newly approved new resource food of the Ministry of Public Health, has very high nutrient and is worth, have antifatigue, anti-oxidant, improve immunity, effect such as delay senility.Research shows that it can prolong the mouse swimming with a load attached to the body time, increases the storage level of the hepatic glycogen of mouse, can also reduce motion front and back blood lactic acid changing value.
In the adjusting immunity of State Food and Drug Administration (SFDA) approval at present or the alleviating physical fatigue class health food most with American Ginseng, cordyceps, the Radix Astragali, to contain aminoacid ingredient be main component, the health food of prescription is less under the drug matching guidance of principle.And it is more rare in the prior art for selecting the new resource food pueraria root powder to cooperate other Chinese medicines to be used for the research of health food or medicine of enhance immunity power, alleviating fatigue.
Summary of the invention
The purpose of this invention is to provide a kind of pueraria root powder ginseng composition; Through the antibody-producting cell number of mouse delayed allergy, mouse, the NK cytoactive of mouse, the ability that mouse monokaryon-macrophage carbon is cleaned up, improve mouse lymphocyte conversion capability, raising mice serum HD50 value; The swimming with a load attached to the body time of mouse, the animal function tests such as blood lactic acid TG-AUC of serum urea level, mouse prove that composition has the health-care efficacy of enhance immunity power, alleviating physical fatigue among the present invention behind the mouse movement.
For achieving the above object; Technical scheme of the present invention provides a kind of pueraria root powder ginseng composition, it is characterized in that, is made up of following materials of weight proportions: 2.5 ~ 8.5 parts of ginseng extracts; 10 ~ 30 parts of gadol extracts; 10 ~ 30 parts of Shorthorned Epimedium P.Es, 6 ~ 18 parts of Fructus lycii P.Es, 75 ~ 250 parts of pueraria root powders.
Preferably, pueraria root powder ginseng composition provided by the invention is characterized in that; Form by following materials of weight proportions: 4 ~ 6 parts of ginseng extracts, 15 ~ 25 parts of gadol extracts, 15 ~ 25 parts of Shorthorned Epimedium P.Es; 10 ~ 15 parts of Fructus lycii P.Es, 100 ~ 200 parts of pueraria root powders.
Further preferably, pueraria root powder ginseng composition provided by the invention is characterized in that, is made up of following materials of weight proportions: 5.5 parts of ginseng extracts, 20 parts of gadol extracts, 20 parts of Shorthorned Epimedium P.Es, 12 parts of Fructus lycii P.Es, 150 parts of pueraria root powders.
The various extracts that relate among the present invention be Chinese medicine material through water carry or alcohol extracting after product; They are extensive use on market all; The preparation of various extracts is existing technology; The product that obtains is difference to some extent on content of material just, and its various products all can practice in the present invention.
Ginseng extract weight proportion of the present invention is according to TSPG 80% cubage; Ginseng extract according to the ginsenoside content in respect of plurality of specifications such as 10% ~ 80%; And be divided into ginseng extract and extract of Radix Ginseng stem and leaf according to the extract part difference; The extract of all size all can be applied to composition of the present invention, and in order to guarantee the curative effect of this composition, ginseng extract of the present invention is according to ginsenoside content 80%; The required umber of other specifications is applied to composition of the present invention after can carrying out corresponding conversion.
Gadol extract of the present invention is according to rhodioloside 5% content meter; Gadol extract according to salidroside content in respect of plurality of specifications such as 1%, 3%, 5%, 7%, 10%; The extract of all size all can be applied to composition of the present invention, and in order to guarantee the curative effect of this composition, gadol extract of the present invention is according to salidroside content 5%; The required umber of other specifications is applied to composition of the present invention after can carrying out corresponding conversion.
Shorthorned Epimedium P.E of the present invention is according to Icariin 10% content meter; Shorthorned Epimedium P.E according to Icariin content in respect of plurality of specifications such as 5%, 10%, 20%; The extract of all size all can be applied to composition of the present invention, and in order to guarantee the curative effect of this composition, Shorthorned Epimedium P.E of the present invention is according to Icariin content 10%; The required umber of other specifications is applied to composition of the present invention after can carrying out corresponding conversion.
Fructus lycii P.E of the present invention is according to thick polysaccharide 60% content meter; Fructus lycii P.E according to thick polyoses content in respect of plurality of specifications such as 30%, 40%, 50%, 60%; The extract of all size all can be applied to composition of the present invention, and in order to guarantee the curative effect of this composition, Fructus lycii P.E of the present invention is according to thick polyoses content 60%; The required umber of other specifications is applied to composition of the present invention after can carrying out corresponding conversion.
Above-mentioned pueraria root powder ginseng composition, wherein said described pueraria root powder is a raw material with the agate coffee, processes un-extracted through steps such as section, drying, pulverizing, sterilizations.Pueraria root powder is without extraction, is but pulverize the advantage of directly using the back, and pueraria root powder is as raw material the time, and the starch that wherein contains, cellulose etc. can be used as auxiliary material, play the effect of filler and lubricant.Under the situation that does not add other auxiliary materials, the present composition can directly be pressed into tablet or be prepared as other formulations, thereby reaches the purpose of simplifying technology, practicing thrift supplementary product consumption.
The present invention also provides a kind of preparation with health care, by above-mentioned pueraria root powder ginseng composition with pharmaceutically reach auxiliary material available in the food industry and form.Usually; Preparation with health care provided by the invention is an oral formulations; Preferred tablet or capsule, said auxiliary material is selected from one or more in starch, amylum pregelatinisatum, pregelatinized starch, dextrin, lactose, microcrystalline cellulose, cross-linked cellulose, sodium carboxymethyl starch, sodium carboxymethylcellulose, low-substituted hydroxypropyl cellulose, dolomol, talcum powder, the superfine silica gel powder.
The preparation method of the oral formulations of above-mentioned pueraria root powder ginseng composition; Adopt this area common method to get final product; The preparation method of present composition tablet for example; May further comprise the steps: pueraria root powder is crossed 80 mesh sieves, sterilization, simultaneously commercial ginseng extract, gadol extract, Shorthorned Epimedium P.E, wolfberry fruit extract are crossed 80 mesh sieves after the assay was approved respectively, use then that mixer is former with each, auxiliary material mixes.The mixed material of mixing can be through granulating process or is directly used the tablet press machine compressing tablet, also can be through granulating process or directly use capsule filling machine encapsulated.
The prescription of health food provided by the invention comes from traditional Chinese medical science prescription; Reinforcing vital energy, answer arteries and veins through gen-seng haulms takes off admittedly; The rhodiola root qi and activate blood circulation, promote blood circulation and relieving asthma; Barrenwort kidney-replenishing, strengthening the bones and muscles, the fruit of Chinese wolfberry is nourishing liver and kidney, benefiting shrewd head, gathers the effect of qi and activate blood circulation, kidney and spleen invigorating, benefiting shrewd head altogether.
The Fang Zhongma coffee is the newly approved new resource food of the Ministry of Public Health, contains anti-fatigue nutrient materials such as rich in protein, amino acid, mineral matter, unrighted acid, has the sexual function of improvement, improves effects such as fecundity, antifatigue, enhance immunity power.Pueraria root powder can be used as auxiliary material as raw material the time, the purpose of simplify technology to reach, practicing thrift supplementary product consumption.
Pueraria root powder ginseng composition provided by the invention, raw material is natural, edible safety, effect is remarkable, has the effect of enhance immunity power, alleviating physical fatigue through animal function test proof.Pueraria root powder ginseng composition provided by the invention, curative effect and definite ingredients, suitable crowd are wide, and the market space is very big, has a good application prospect.
The specific embodiment
Below in conjunction with embodiment, specific embodiments of the invention describes in further detail.Following examples are used to explain the present invention, but are not used for limiting scope of the present invention.
Embodiment 1: the pueraria root powder ginseng composition
Component: ginseng extract (ginsenoside content 80%) 2.5g; Gadol extract (salidroside content 5%) 20g; Shorthorned Epimedium P.E (Icariin content 10%) 30g, Fructus lycii P.E (thick polyoses content 60%) 6g, pueraria root powder (un-extracted; Contain fiber, starchy material) 250g, dolomol 6.5g.
Preparation technology is following:
1, commercially available high-quality pueraria root powder is crossed 80 mesh sieves, and sterilization is subsequent use;
2, ginseng extract, gadol extract, Shorthorned Epimedium P.E, Fructus lycii P.E, pueraria root powder and dolomol are crossed 80 mesh sieves respectively, take by weighing each raw material after treatment respectively, mix in the input mixer by formula rate;
3, the mixed material of mixing uses the tablet press machine compressing tablet, processes 600 in tablet, every heavy 0.525g; Choose defective (flower sheet, sliver, imperfect etc.), select the qualified sheet of outward appearance;
4, through packing, product inspection, obtain product.
Embodiment 2: the pueraria root powder ginseng composition
Component: ginseng extract (ginsenoside content 80%) 5.5g; Gadol extract (salidroside content 5%) 30g, Shorthorned Epimedium P.E (Icariin content 10%) 10g, Fructus lycii P.E (thick polyoses content 60%) 12g; Pueraria root powder (un-extracted; The fiber that contains, starchy material) 75g, microcrystalline cellulose 72.5g, talcum powder 5g.
Preparation technology is following:
1, commercially available high-quality pueraria root powder is crossed 80 mesh sieves, and sterilization is subsequent use;
2, ginseng extract, gadol extract, Shorthorned Epimedium P.E, Fructus lycii P.E, pueraria root powder microcrystalline cellulose, talcum powder are crossed 80 mesh sieves respectively, take by weighing each raw material after treatment respectively, mix in the input mixer by formula rate;
3, it is encapsulated that the mixed material of mixing uses capsule filling machine, processes 600 of capsules, and every contains content 0.35g; Capsule is put in the medicine polishing machine, and defective capsule (lopsided capsule, leakage capsule) is chosen in polishing, selects the qualified capsule of outward appearance;
4, through packing, product inspection, obtain product.
Embodiment 3: the pueraria root powder ginseng composition
Component: ginseng extract (ginsenoside content 80%) 8.5g; Gadol extract (salidroside content 5%) 10g; Shorthorned Epimedium P.E (Icariin content 10%) 20g, Fructus lycii P.E (thick polyoses content 60%) 18g, pueraria root powder (un-extracted; The fiber that contains, starchy material) 150g, superfine silica gel powder 3.5g.Process 600 of capsule preparations, be the 0.35g/ grain.
Except that amounts of components and embodiment 2 were different, all the other were with embodiment 2.
Embodiment 4: the pueraria root powder ginseng composition
Component: ginseng extract (ginsenoside content 80%) 5.5g; Gadol extract (salidroside content 5%) 20g; Shorthorned Epimedium P.E (Icariin content 10%) 20g, Fructus lycii P.E (thick polyoses content 60%) 12g, pueraria root powder (un-extracted; Contain fiber, starchy material) 150g, dolomol 2.5g.Process 600 of capsule preparations, be the 0.35g/ grain.
Except that amounts of components and embodiment 2 were different, all the other were with embodiment 2.
Embodiment 5: the pueraria root powder ginseng composition
Component: ginseng extract (ginsenoside content 80%) 8.5g; Gadol extract (salidroside content 5%) 30g; Shorthorned Epimedium P.E (Icariin content 10%) 30g; Fructus lycii P.E (thick polyoses content 60%) 18g, pueraria root powder (un-extracted, the fiber that contains, starchy material) 250g.
Preparation technology is following:
1, commercially available high-quality pueraria root powder is crossed 80 mesh sieves, and sterilization is subsequent use;
2, ginseng extract, gadol extract, Shorthorned Epimedium P.E, Fructus lycii P.E and pueraria root powder are crossed 80 mesh sieves respectively, take by weighing each raw material after treatment respectively, mix in the input mixer by formula rate;
3, the mixed material of mixing uses the tablet press machine compressing tablet, processes 600 in tablet, every heavy 0.561g; Choose defective (flower sheet, sliver, imperfect etc.), select the qualified sheet of outward appearance;
4, through packing, product inspection, obtain product.
Embodiment 6:
Component: ginseng extract (ginsenoside content 80%) 2.5g, gadol extract (salidroside content 5%) 10g, Shorthorned Epimedium P.E (Icariin content 10%) 10g; Fructus lycii P.E (thick polyoses content 60%) 6g, pueraria root powder (un-extracted, the fiber that contains, starchy material) 75g; Starch 10.5g, amylum pregelatinisatum 6g, pregelatinized starch 6g; Dextrin 10g, lactose 12g, microcrystalline cellulose 15g, cross-linked cellulose 18g; Sodium carboxymethyl starch 12g, sodium carboxymethylcellulose 10g, low-substituted hydroxypropyl cellulose 7g.Process 600 of capsule preparations, be the 0.35g/ grain.
Except that amounts of components and embodiment 2 were different, all the other were with embodiment 2.
Test Example: following through experimental data, effect of the present invention is described.
Toxicological test:
Test objective: whether the check product has toxicity
The capsule that test material: embodiment 4 makes
Sample: the oral recommended amounts of human body is the 0.35g/ grain, every day 2 times, each 3.Become body weight for humans to press 60kg and calculate, amount to dosage 0.035g/kgbw (0.035 gram/kg body weight).Getting capsule 's content makes an experiment
Animal used as test: cleaning level Kunming mouse, SD rat and feed
Experimental situation condition: temperature 22-24 ℃, humidity 52-58 ℃.
Test method:
Through acute toxicity test in mice (get the capsule 25g that embodiment 4 makes, adding distil water is to 50mL, gets in this liquid one day at interval and to irritate stomach to its mouse oral in 4 hours, irritates stomach altogether 2 times, irritates at every turn that body of stomach is long-pending to be 0.2mL/10gbw, and cumulative measurement is 20.0g/kgbw); Salmonella reversion test (is got the capsule 1.25g that embodiment 4 makes; Adding distil water is to 25mL; Be the dosage (every ware 0.1mL) of 5000 μ g/ wares, five dosage are established in test, are respectively 5000 μ g/ wares, 1000 μ g/ wares, 200 μ g/ wares, 40 μ g/ wares, 8 μ g/ wares; Add strain culturing, establish simultaneously) from beaming back change, solvent control and the contrast of positive mutagens; The PCEMNR micronucleus test is (with the positive contrast of endoxan of 40mg/ kgbw dosage; The negative contrast of distilled water; 3 dosage of test group are respectively 10.0g/ kgbw, 5.0g/ kgbw, 2.5g/ kgbw, get capsule 50.0g that embodiment 4 makes, 25.0g, 12.5g respectively adding distil water be made into the test solution that receives of corresponding dosage to 100mL; Irritate stomach to its mouse oral, irritate the long-pending 0.2mL/10gbw of being of body of stomach); The mouse sperm deformity test is (with the positive contrast of endoxan of 40mg/ kgbw dosage; The negative contrast of distilled water; 3 dosage of test group are respectively 10.0g/ kgbw, 5.0g/ kgbw, 2.5g/ kgbw, get capsule 50.0g that embodiment 4 makes, 25.0g, 12.5g respectively adding distil water be made into the test solution that receives of corresponding dosage to 100mL; Irritate stomach to its mouse oral, irritate the long-pending 0.2mL/10gbw of being of body of stomach); 30 days feeding trials (are got capsule 8.75 g/ kgbw, 17.5 g/ kgbw, the 35.0 g/ kgbw adding distil waters that embodiment 4 makes and are settled to 100mL; 3 dosage of test group are respectively 0.88 g/ kgbw, 1.75 g/ kgbw, 3.50 g/ kgbw control groups and give and equal-volume distilled water; Irritate stomach once to rat oral every day, continuous 30 days) carry out the toxicological experiment evaluation.
Result of the test:
1, anxious poisons mouth toxicity test result: the maximum tolerated dose (MTD) of female, male mice in kunming all greater than 20.0 g/ kgbw, is belonged to nontoxic level;
2, Salmonella reversion test, PCEMNR micronucleus test, mouse sperm deformity result of the test are all negative as a result for three genetic toxicity tests;
3,30 days feeding trial results: give rat oral gavage 30 days with 0.88 g/ kgbw, 1.75 g/ kgbw, 3.50 g/ kgbw dosage (be equivalent to human body RD 25,50,100 times); Duration of test; Animal growth is good; Each dose groups body weight, weightening finish, food utilization, routine blood test index, blood biochemistry index, internal organs weight in wet base and internal organs/body weight ratio and control group compare, no significant difference (P>0.05).Gross anatomy is not seen the abnormal change relevant with sample with tissue pathology checking.
Function test:
Test objective: whether the check product has the function of this enhance immunity power, alleviating physical fatigue.
1, function of enhancing immunity:
Test material:
The capsule that sample: embodiment 4 makes, the oral recommended amounts of human body is the 0.35g/ grain, every day 2 times, each 3.Become body weight for humans to press 60kg and calculate, amount to dosage 0.035g/kgbw.Getting capsule 's content makes an experiment
Experimental animal: 200 of cleaning level Kunming kind female mices, body weight is 18-22g
Experimental enviroment condition: barrier system.Temperature 22-24 ℃, humidity 52-58%
Dosage is selected and sample treatment: establish the basic, normal, high dosage of pueraria root powder Panax Capsule and be respectively 0.175g/kgbw, 0.35 g/kgbw, 1.05 g/kgbw (be equivalent to respectively human body RD 5,10,30 times).Basic, normal, high dosage receives test solution when configuration, gets capsule 's content 1.75g, 3.50g, 10.50g adding distil water respectively and is settled to 200mL, and control group is given isopyknic distilled water; Give animal subject respectively and irritate stomach; Irritate stomach every day once, irritate the long-pending 0.2mL/kgbw of being of body of stomach, continuous 30 days
Key instrument and reagent: animal platform balance, assay balance, clean bench, CO2gas incubator, autoclave, filter, centrifuge, 722 spectrophotometers, constant water bath box, ELIASA, microscope etc.
Test method: mouse lymphocyte transformation experiment, antibody-producting cell detection, the mensuration of HD50 value, the mouse carbon of inducing through internal organs/weight ratio pH-value determination pH, delayed allergy, ConA is cleaned up the determination experiment that experiment, Turnover of Mouse Peritoneal Macrophages engulf chicken red blood cell experiment, NK cytoactive and is carried out assessment of function.
Result of the test:
Per os is given and the pueraria root powder Panax Capsule of mouse 0.175g/kgbw, 0.35 g/kgbw, 1.05 g/kgbw dosage 30 days; 0.35 g/kgbw, 1.05 g/kgbw dosage can strengthen the mouse delayed allergy, improve the antibody-producting cell number of mouse, improve the NK cytoactive of mouse; 1.05 g/kgbw dosage can improve ability, raising mouse lymphocyte conversion capability, raising mice serum HD50 value that mouse monokaryon-macrophage carbon is cleaned up, P < 0.05.The ability of weight of mice, spleen/body weight ratio, thymus gland/body weight ratio, macrophage phagocytic chicken red blood cell is not seen obvious influence (P>0.05).Under this experiment condition, point out this sample to have the function of enhance immunity power.
Concrete result of the test data see the following form:
Table 1 pueraria root powder Panax Capsule is to the influence of mouse delayed allergy (DTH)
Can be known that by table 1 per os gives the pueraria root powder Panax Capsule 30 days of mouse various dose, middle and high dose groups swelling degree of the paw is apparently higher than control group, and difference has conspicuousness (P < 0.05).
The influence that the mouse lymphocyte conversion capability that table 2 pueraria root powder Panax Capsule is induced mouse ConA is tested
Can be known that by table 2 per os gives the pueraria root powder Panax Capsule 30 days of mouse various dose, high dose group mouse lymphocyte conversion capability is apparently higher than control group, and difference has conspicuousness (P < 0.05).
Table 3 pueraria root powder Panax Capsule is to the influence of mouse antibodies cellulation number
Can be known that by table 3 per os gives the pueraria root powder Panax Capsule 30 days of mouse various dose, middle and high dose groups antibody-producting cell number is apparently higher than control group, and difference has conspicuousness (P < 0.05).
Table 4 pueraria root powder Panax Capsule is to mouse HD50 value (HC
50) influence
Can be known that by table 4 per os gives the pueraria root powder Panax Capsule 30 days of mouse various dose, high dose group mouse HD50 value is apparently higher than control group, and difference has conspicuousness (P < 0.05).
Table 5 pueraria root powder Panax Capsule is to influence that mouse monokaryon-macrophage carbon is cleaned up
Can be known that by table 5 per os gives the pueraria root powder Panax Capsule 30 days of mouse various dose, high dose group mouse phagocytic index is apparently higher than control group, and difference has conspicuousness (P < 0.05).
Table 6 pueraria root powder Panax Capsule is to the active influence of NK cells in mice
Can be known that by table 6 per os gives the pueraria root powder Panax Capsule 30 days of mouse various dose, middle and high dose groups NK cells in mice activity is apparently higher than control group, and difference has conspicuousness (P < 0.05).
2, alleviating physical fatigue function:
Test material:
The capsule that sample: embodiment 4 makes, the oral recommended amounts of human body is the 0.35g/ grain, every day 2 times, each 3.Become body weight for humans to press 60kg and calculate, amount to dosage 0.035g/kgbw.Getting capsule 's content makes an experiment
Experimental animal: 160 of cleaning level Male Kunming strain mice, body weight is 18-22g
Experimental enviroment condition: barrier system.Temperature 22-24 ℃, humidity 52-58%
Dosage is selected and sample treatment: establish the basic, normal, high dosage of pueraria root powder Panax Capsule and be respectively 0.175g/kgbw, 0.35 g/kgbw, 1.05 g/kgbw (be equivalent to respectively human body RD 5,10,30 times).Basic, normal, high dosage receives test solution when configuration, gets capsule 's content 1.75g, 3.50g, 10.50g adding distil water respectively and is settled to 200mL, and control group is given isopyknic distilled water; Give animal subject respectively and irritate stomach; Irritate stomach every day once, irritate the long-pending 0.2mL/kgbw of being of body of stomach, continuous 30 days
Key instrument and reagent: animal platform balance, assay balance, centrifuge, clasmatosis appearance, water bath, oscillator, OLYMPUSAU400 automatic clinical chemistry analyzer, 722 spectrophotometers, swimming case, sheet lead, timer, hemochrome suction pipe, sample injector, test tube etc.
Test method: carry out assessment of function through swimming with a load attached to the body test, serum urea mensuration, hepatic glycogen mensuration, blood lactic acid determination experiment.
Result of the test:
Per os is given and the pueraria root powder Panax Capsule of mouse 0.175g/kgbw, 0.35 g/kgbw, 1.05 g/kgbw dosage 30 days; 0.35 g/kgbw, 1.05 g/kgbw dosage can prolong the swimming with a load attached to the body time of mouse; 1.05 g/kgbw dosage can will offset number motion back serum urea level, reduce the blood lactic acid TG-AUC of mouse, P < 0.05.Mouse Liver glycogen storage level is not seen obvious influence (P>0.05).Under this experiment condition, point out this sample to have the function of alleviating physical fatigue.
Concrete result of the test data see the following form:
Table 7 pueraria root powder Panax Capsule is to the influence of mouse swimming with a load attached to the body time
Can be known that by table 7 per os gives the pueraria root powder Panax Capsule 30 days of mouse various dose, the middle and high dose groups mouse swimming with a load attached to the body time is apparently higher than control group, and difference has conspicuousness (P < 0.05).
Table 8 pueraria root powder Panax Capsule is to the influence of mice serum urea
Can be known that by table 8 per os gives the pueraria root powder Panax Capsule 30 days of mouse various dose, high dose group mice serum urea nitrogen is starkly lower than control group, and difference has conspicuousness (P < 0.05).
The influence (
) that table 9 pueraria root powder Panax Capsule changes mouse blood lactic acid
Can be known that by table 9 per os gives the pueraria root powder Panax Capsule 30 days of mouse various dose, high dose group mouse blood lactic acid TG-AUC is starkly lower than control group, and difference has conspicuousness (P < 0.05).
Claims (10)
1. a pueraria root powder ginseng composition is characterized in that being made up of following materials of weight proportions: 2.5 ~ 8.5 parts of ginseng extracts, 10 ~ 30 parts of gadol extracts, 10 ~ 30 parts of Shorthorned Epimedium P.Es, 6 ~ 18 parts of Fructus lycii P.Es, 75 ~ 250 parts of pueraria root powders.
2. pueraria root powder ginseng composition as claimed in claim 1; It is characterized in that forming: 4 ~ 6 parts of ginseng extracts, 15 ~ 25 parts of gadol extracts, 15 ~ 25 parts of Shorthorned Epimedium P.Es by following materials of weight proportions; 10 ~ 15 parts of Fructus lycii P.Es, 100 ~ 200 parts of pueraria root powders.
3. pueraria root powder ginseng composition as claimed in claim 1 is characterized in that being made up of following materials of weight proportions: 5.5 parts of ginseng extracts, 20 parts of gadol extracts, 20 parts of Shorthorned Epimedium P.Es, 12 parts of Fructus lycii P.Es, 150 parts of pueraria root powders.
4. like each described pueraria root powder ginseng composition of claim 1-3; It is characterized in that the ginsenoside content is 80% in the ginseng extract; Salidroside content is 5% in the gadol extract; Icariin content is 10% in the Shorthorned Epimedium P.E, and thick polyoses content is 60% in the Fructus lycii P.E.
5. like each described pueraria root powder ginseng composition of claim 1-3, it is characterized in that pueraria root powder is a raw material with the agate coffee, process un-extracted through steps such as section, drying, pulverizing, sterilizations.
6. preparing enhance immunity power, the medicine of alleviating physical fatigue or the purposes in the health food like each described pueraria root powder ginseng composition among the claim 1-3.
7. the preparation with health care is characterized in that being made up of available auxiliary material in each described pueraria root powder ginseng composition of claim 1-3 and pharmacy and the food industry.
8. the preparation with health care as claimed in claim 7 is characterized in that said auxiliary material is selected from one or more in starch, amylum pregelatinisatum, pregelatinized starch, dextrin, lactose, microcrystalline cellulose, cross-linked cellulose, sodium carboxymethyl starch, sodium carboxymethylcellulose, low-substituted hydroxypropyl cellulose, dolomol, talcum powder, the superfine silica gel powder.
9. the preparation with health care as claimed in claim 7 is characterized in that, said preparation is an oral formulations.
10. the preparation with health care as claimed in claim 9 is characterized in that, said preparation is tablet or capsule.
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