CN102836283A - Anti-fatigue oral liquid and preparation method thereof - Google Patents

Anti-fatigue oral liquid and preparation method thereof Download PDF

Info

Publication number
CN102836283A
CN102836283A CN2012103567490A CN201210356749A CN102836283A CN 102836283 A CN102836283 A CN 102836283A CN 2012103567490 A CN2012103567490 A CN 2012103567490A CN 201210356749 A CN201210356749 A CN 201210356749A CN 102836283 A CN102836283 A CN 102836283A
Authority
CN
China
Prior art keywords
parts
oral liquid
radix
resisting fatigue
extractum
Prior art date
Application number
CN2012103567490A
Other languages
Chinese (zh)
Inventor
韦卫
Original Assignee
韦卫
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 韦卫 filed Critical 韦卫
Priority to CN2012103567490A priority Critical patent/CN102836283A/en
Publication of CN102836283A publication Critical patent/CN102836283A/en

Links

Abstract

The invention relates to anti-fatigue oral liquid and a preparation method thereof. The oral liquid is prepared by taking the seven traditional Chinese herbal medicines such as ginseng, liquorice, acanthopanax senticosus, medlar, Indian buead, herba cistanche and radix astragali as raw materials, extracting the active ingredients through poaching, alcohol extraction and alcohol precipitation and adding pharmaceutically acceptable auxiliaries. The method is simple and easy to operate and is safe and effective. The prepared oral liquid has high extract purity, few impurities and obvious pharmacological and pharmacodynamic effects and can effectively relieve physical fatigue and improve the human immune function.

Description

Resisting fatigue oral liquid and preparation method thereof
Technical field
The invention belongs to the Chinese medicine and health food field, relate generally to a kind of resisting fatigue oral liquid and preparation method thereof.
Background technology
Along with social competition is fierce day by day, the each side pressure that people face is increasing, and in many people's sub-health states, it is inferior to show as malaise, easy fatigue, hypomnesis, inefficiency, has a strong impact on the live and work quality.Motherland's medical science thinks, lassitude and weak is all much because of overworked, excessive thinking, pressure, and gently then insufficiency of vital energy and blood, imbalance of YIN and YANG are heavy then to involve internal organs dirty, and tired symptom such as weak appears in functional disorder.Modern medicine thinks, testosterone can stimulate kidney to discharge erythropoietin, promotes the synthetic of erythrocytic generation and hemoglobin, makes muscle glycogen, phosphagen is synthetic increases, and helps diseases such as relieving fatigue is weak.
Herbal pharmacology discovers that the effective ingredient in the part Chinese medicine can improve the endogenous testosterone levels, can also prevent the appearance of the low testosterone of mobility simultaneously, can effectively resist organism fatigue, improves body immunity.Therefore, be mainly used in resisting fatigue, the Chinese medicine oral liquid of alleviating hypoimmunity are just arisen at the historic moment.
At present, problem such as the anti-fatigue Chinese medicine oral liquid of selling on the market generally adopts decocting method, ethanol extraction method to extract the effective ingredient in the Chinese medicine, but has the effective component content instability easily, and impurity is more influences the clarity and the impression of finished product oral liquid.
Summary of the invention
The technical problem that the present invention will solve provides good, stay-in-grade resisting fatigue oral liquid of clarity and preparation method thereof.
The technical scheme that the present invention will provide provides a kind of effective ingredient purity height, impurity is few; The pharmacological effect effect is remarkable; Effective alleviating physical fatigue; Improve human immunologic function's Chinese medicine oral liquid, form by the raw material of following weight parts: 10~15 parts of Radix Ginsengs, 6~15 parts in Radix Glycyrrhizae, 10~15 parts of Radix Et Caulis Acanthopanacis Senticosis, 5~25 parts of Fructus Lyciis, 9~30 parts in Poria, 10~30 parts of Herba Cistanches, 15~20 parts of the Radixs Astragali.
According to a particular embodiment of the invention, preferred weight part proportioning of above-mentioned raw materials is: 12 parts of Radix Ginsengs, 10 parts in Radix Glycyrrhizae, 13 parts of Radix Et Caulis Acanthopanacis Senticosis, 15 parts of Fructus Lyciis, 15 parts in Poria, 20 parts of Herba Cistanches, 18 parts of the Radixs Astragali.
The present invention also provides the method for preparing of above-mentioned resisting fatigue oral liquid, comprises the steps:
1) take by weighing Radix Ginseng, Radix Et Caulis Acanthopanacis Senticosi, Fructus Lycii, Poria, the Radix Astragali by proportioning, be ground into coarse powder and be placed in the extraction pot, add the water of 6~10 times of inventorys, heating and refluxing extraction 1~3 time each 1~2.5 hour, is filtered merging filtrate;
2) above-mentioned filtrating is adsorbed through macroporous resin, with distilled water eluting residual impurity, reuse 30%~80% (v/v) ethanol elution is collected eluent to colourless, and it is 1.1~1.2 extractum A that eluent is concentrated into relative density, subsequent use;
3) take by weighing Radix Ginseng, Herba Cistanches by proportioning, be ground into coarse powder and be placed in the extraction pot, 60%~80% (v/v) ethanol extraction that the adding inventory is 8~10 times 1~2 time; Each 1~2 hour, filter merging filtrate; Filtrating is concentrated into relative density is 1.1~1.2 extractum B, subsequent use;
4) with step 2) the extractum B that makes of the extractum A that makes and step 3) merges, and makes the resisting fatigue oral liquid by conventional method.
According to a particular embodiment of the invention, step 2) and the simmer down to vacuum concentration described in the step 3), its vacuum is that 0.02~0.04MPa, temperature are 65~70 ℃.
According to a particular embodiment of the invention, in the step 1), described coarse powder granularity is 40~50 orders.
According to a particular embodiment of the invention, in the step 3), described coarse powder granularity is 30~60 orders.
In the above-mentioned Chinese prescription, the ginsenoside of containing in the Radix Ginseng is the antifatigue major function factor, and body is had the effect of strengthening by means of tonics, the effect that the body of subhealth state is had regulatory function; Radix Et Caulis Acanthopanacis Senticosi has replenishing QI to invigorate the spleen, the function of invigorating QI and tranquilization, and the total glycosides that contains in the Radix Et Caulis Acanthopanacis Senticosi is the effective ingredient of resisting fatigue, strengthening the body resistance; Fructus Lycii, the effect that has kidney-tonifying sperm-generating, nourishing the liver, makes eye bright and calm the nerves cures mainly caused by liver and kidney deficiency, has a dizzy spell, visual unclear, soreness of the waist and knees, impotence and seminal emission, cough due to consumptive disease, the taking fluids profusely of quenching one's thirst; Poria has the function of promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming, modern medicine study: Poria can the enhancing human body immunity function, and pachyman has tangible antitumor and protects the liver dirty effect; Herba Cistanches, kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation are used for sexual impotence, and be infertile, soreness of the waist and knees, muscles and bones is unable, the dryness of the intestine constipation; Radix Glycyrrhizae has the effect of heat-clearing and toxic substances removing, expelling phlegm for arresting cough, gastral cavity abdomen, is splendid tonification good medicine; The Radix Astragali contains various trace elements such as Saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper, the enhancing human body immunity function is arranged, protects the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.
The present invention adopts macroporous resin can effectively remove impurity such as saccharides a large amount of in the decoction liquor, inorganic salt, lymphatic temperament, makes effective ingredient highly enriched, and impurity is few, and finished product stability is good, clarity is high.The present invention is set up prescriptions of Chinese medicine according to theory of Chinese medical science, and through comprehensive adjustment people's functional status, replenishing vital essence and invigorating vital QI, the foster lung of spleen invigorating, blood stasis dispelling circulation of qi promoting, promoting digestion and removing stagnation, heat clearing away are refreshed oneself, the expectorant diuresis, reach the antagonism organism fatigue, the effect of enhancing human body immunity power.
The specific embodiment
Below in conjunction with embodiment the present invention is done detailed elaboration, but not as limitation of the present invention.
Embodiment 1
1) take by weighing 10g Radix Et Caulis Acanthopanacis Senticosi, 5g Fructus Lycii, 9g Poria, the 15g Radix Astragali, be ground into 40 order coarse powder and be placed in the extraction pot, add the water of 6 times of inventorys, heating and refluxing extraction 1 hour is filtered, and gets filtrate for later use;
2) above-mentioned filtrating is adsorbed through D101 type macroporous resin; With distilled water eluting residual impurity, reuse 30% (v/v) ethanol elution is collected eluent to colourless; Is that 0.02MPa, temperature are that to be concentrated into relative density under 65 ℃ be 1.1 extractum A with eluent in vacuum, subsequent use;
3) take by weighing 10g Radix Ginseng, 10g Herba Cistanches by proportioning; Be ground into 30 order coarse powder and be placed in the extraction pot, 60% (v/v) ethanol extraction that the adding inventory is 8 times 1 hour filters; To filtrate in vacuum is that 0.02MPa, temperature are to be concentrated into relative density under 65 ℃ to be 1.1 extractum B, subsequent use;
4) with step 2) the extractum B that makes of the extractum A that makes and step 3) merges, and makes the resisting fatigue oral liquid by conventional method, and be packed as 10ml/ and prop up.
Embodiment 2
1) take by weighing 15g Radix Et Caulis Acanthopanacis Senticosi, 25g Fructus Lycii, 30g Poria, the 25g Radix Astragali, be ground into 50 order coarse powder and be placed in the extraction pot, add the water of 10 times of inventorys, heating and refluxing extraction 3 times each 2.5 hours, is filtered merging filtrate;
2) above-mentioned filtrating is adsorbed through AB/B type macroporous resin; With distilled water eluting residual impurity, reuse 80% (v/v) ethanol elution is collected eluent to colourless; Is that 0.04MPa, temperature are that to be concentrated into relative density under 70 ℃ be 1.2 extractum A with eluent in vacuum, subsequent use;
3) take by weighing 15g Radix Ginseng, 30g Herba Cistanches; Be ground into 60 order coarse powder and be placed in the extraction pot, 80% (v/v) ethanol extraction that the adding inventory is 10 times 2 times, each 2 hours; Filter; Merging filtrate, will filtrate in vacuum is that 0.04MPa, temperature are to be concentrated into relative density under 70 ℃ to be 1.2 extractum B, subsequent use;
4) with step 2) the extractum B that makes of the extractum A that makes and step 3) merges, and makes the resisting fatigue oral liquid by conventional method, and be packed as 10ml/ and prop up.
Embodiment 3
1) take by weighing 13g Radix Et Caulis Acanthopanacis Senticosi, 15g Fructus Lycii, 15g Poria, the 18g Radix Astragali by proportioning, be ground into 45 order coarse powder and be placed in the extraction pot, add the water of 8 times of inventorys, heating and refluxing extraction 2 times each 2 hours, is filtered merging filtrate;
2) above-mentioned filtrating is adsorbed through the D201 macroporous resin; With distilled water eluting residual impurity, reuse 60% (v/v) ethanol elution is collected eluent to colourless; Is that 0.03MPa, temperature are that to be concentrated into relative density under 68 ℃ be 1.15 extractum A with eluent in vacuum, subsequent use;
3) take by weighing 12g Radix Ginseng, 20g Herba Cistanches; Be ground into 50 order coarse powder and be placed in the extraction pot, 70% (v/v) ethanol extraction that the adding inventory is 9 times 1 time, each 1.5 hours; Filter; Merging filtrate, will filtrate in vacuum is that 0.03MPa, temperature are to be concentrated under 68 ℃ to relative density to be 1.15 extractum B, subsequent use;
4) with step 2) the extractum B that makes of the extractum A that makes and step 3) merges, and makes the resisting fatigue oral liquid by conventional method, and be packed as 10ml/ and prop up.
Embodiment 4
1) take by weighing 10g Radix Et Caulis Acanthopanacis Senticosi, 25g Fructus Lycii, 9g Poria, the 20g Radix Astragali by proportioning, be ground into 40 order coarse powder and be placed in the extraction pot, add the water of 6 times of inventorys, heating and refluxing extraction 2.5 hours is filtered merging filtrate;
2) above-mentioned filtrating is adsorbed through the GDXl04 macroporous resin; With distilled water eluting residual impurity, reuse 30% (v/v) ethanol elution is collected eluent to colourless; Is that 0.02MPa, temperature are that to be concentrated into relative density under 70 ℃ be 1.2 extractum A with eluent in vacuum, subsequent use;
3) take by weighing 10g Radix Ginseng, 30g Herba Cistanches; Be ground into 30 order coarse powder and be placed in the extraction pot, 80% (v/v) ethanol extraction that the adding inventory is 8 times 2 times, each 1 hour; Filter; Merging filtrate, will filtrate in vacuum is that 0.04MPa, temperature are to be concentrated into relative density under 65 ℃ to be 1.2 extractum B, subsequent use;
4) with step 2) the extractum B that makes of the extractum A that makes and step 3) merges, and makes the resisting fatigue oral liquid by conventional method, and be packed as 10ml/ and prop up.
Experimental example
Be the beneficial effect of proof resisting fatigue oral liquid of the present invention, the present invention has carried out the clinical observation of system, and relevant situation is summarized as follows:
Patient profile: select 100 examples and suffer from easy fatigue, weak, the hypomnesis in the whole body, dim-sighted, the soreness of the waist and knees of the head; Subhealth symptom persons such as sexual disorder are experimental group, male's 50 examples wherein, women's 50 examples; At 18~60 years old age, the course of disease is from starting phase to 25 year.Be divided into two groups at random, 50 parts every group, one group is experimental group, and one group is matched group.Experimental group: cut out other drug, take the oral liquid that the embodiment of the invention 3 makes.Matched group: the other drug of stopping using, take Oral Liquid Radix Panacis Quinquefolii (all living creatures' Tetramune Engineering Co., Ltd is good in the Xiamen).
Instructions of taking: one day three, each one (10ml), in ante cibum warm water send good fortune.One month is a course of treatment, totally three courses of treatment.
Criterion of therapeutical effect: diseases such as produce effects-limbs fatigue, soreness of the waist and knees disappear basically, and energy is obviously abundant.
Disease such as improvement-limbs fatigue, soreness of the waist and knees is clearly better, and energy is comparatively abundant.
Invalid-each item symptom does not all have improvement.
Efficacy result (after three courses of treatment):
Group The example number Produce effects Take a turn for the better Invalid Effective percentage
The treatment group 50 21 26 3 94%
Matched group 50 18 24 8 84%
Can know that by above-mentioned contrast experiment resisting fatigue oral liquid therapeutic equivalence provided by the invention is obvious.

Claims (6)

1. resisting fatigue oral liquid, it is characterized in that: it is to be processed by the raw material of following weight parts: 10~15 parts of Radix Ginsengs, 6~15 parts in Radix Glycyrrhizae, 10~15 parts of Radix Et Caulis Acanthopanacis Senticosis, 5~25 parts of Fructus Lyciis, 9~30 parts in Poria, 10~30 parts of Herba Cistanches, 15~20 parts of the Radixs Astragali.
2. a kind of resisting fatigue oral liquid according to claim 1 is characterized in that: the weight portion proportioning of its raw material is: 12 parts of Radix Ginsengs, 10 parts in Radix Glycyrrhizae, 13 parts of Radix Et Caulis Acanthopanacis Senticosis, 15 parts of Fructus Lyciis, 15 parts in Poria, 20 parts of Herba Cistanches, 18 parts of the Radixs Astragali.
3. the method for preparing of claim 1 or 2 described resisting fatigue oral liquids is characterized in that: comprise the steps:
1) take by weighing Radix Et Caulis Acanthopanacis Senticosi, Fructus Lycii, Poria, the Radix Astragali by proportioning, be ground into coarse powder and be placed in the extraction pot, add the water of 6~10 times of inventorys, heating and refluxing extraction 1~3 time each 1~2.5 hour, is filtered merging filtrate;
2) above-mentioned filtrating is adsorbed through macroporous resin, with distilled water eluting residual impurity, reuse 30%~80% (v/v) ethanol elution is collected eluent to colourless, and it is 1.1~1.2 extractum A that eluent is concentrated into relative density, subsequent use;
3) take by weighing Radix Ginseng, Herba Cistanches by proportioning, be ground into coarse powder and be placed in the extraction pot, 60%~80% (v/v) ethanol extraction that the adding inventory is 8~10 times 1~2 time; Each 1~2 hour, filter merging filtrate; Filtrating is concentrated into relative density is 1.1~1.2 extractum B, subsequent use;
4) with step 2) the extractum B that makes of the extractum A that makes and step 3) merges, and makes the resisting fatigue oral liquid by conventional method.
4. the method for preparing of resisting fatigue oral liquid according to claim 3 is characterized in that: step 2) and step 3) described in the simmer down to vacuum concentration, its vacuum is that 0.02~0.04MPa, temperature are 65~70 ℃.
5. the method for preparing of resisting fatigue oral liquid according to claim 3 is characterized in that: in the step 1), described coarse powder granularity is 40~50 orders.
6. the method for preparing of resisting fatigue oral liquid according to claim 3 is characterized in that: in the step 3), described coarse powder granularity is 30~60 orders.
CN2012103567490A 2012-09-21 2012-09-21 Anti-fatigue oral liquid and preparation method thereof CN102836283A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN2012103567490A CN102836283A (en) 2012-09-21 2012-09-21 Anti-fatigue oral liquid and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN2012103567490A CN102836283A (en) 2012-09-21 2012-09-21 Anti-fatigue oral liquid and preparation method thereof

Publications (1)

Publication Number Publication Date
CN102836283A true CN102836283A (en) 2012-12-26

Family

ID=47364186

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2012103567490A CN102836283A (en) 2012-09-21 2012-09-21 Anti-fatigue oral liquid and preparation method thereof

Country Status (1)

Country Link
CN (1) CN102836283A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103494133A (en) * 2013-08-23 2014-01-08 朱奕 Antifatigue health-care ginseng oral liquid and preparation method thereof
CN103859412A (en) * 2014-04-02 2014-06-18 南京慧博生物科技有限公司 Health-care food for male and preparation method thereof
CN104127699A (en) * 2014-08-06 2014-11-05 周思瑶 Vitality-tonifying health-preserving preparation and preparation method thereof
CN104397710A (en) * 2014-12-12 2015-03-11 香格里拉县天丽斯生物科技发展有限公司 Composition capable of improving fatigue condition
CN105726622A (en) * 2014-12-08 2016-07-06 中国人民解放军第二军医大学 Anti-fatigue traditional Chinese medicine combined extract and its preparation method and use
CN106107294A (en) * 2016-07-16 2016-11-16 成都圣弘源生物科技有限公司 A kind of compound recipe plateau hippophae rhamnoides beverage and preparation method thereof
CN107223966A (en) * 2017-05-09 2017-10-03 新疆生命核力高科股份有限公司 It is a kind of to be used to improve sweet oral liquid of Rong's grass of immunity and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101288478A (en) * 2008-05-28 2008-10-22 河北科技大学 Nutrient capable of enhancing resistance and preparation method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101288478A (en) * 2008-05-28 2008-10-22 河北科技大学 Nutrient capable of enhancing resistance and preparation method thereof

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103494133A (en) * 2013-08-23 2014-01-08 朱奕 Antifatigue health-care ginseng oral liquid and preparation method thereof
CN103494133B (en) * 2013-08-23 2015-07-15 朱奕 Antifatigue health-care ginseng oral liquid and preparation method thereof
CN103859412A (en) * 2014-04-02 2014-06-18 南京慧博生物科技有限公司 Health-care food for male and preparation method thereof
CN103859412B (en) * 2014-04-02 2015-06-03 江苏慧博生物科技有限公司 Health-care food for male and preparation method thereof
CN104127699A (en) * 2014-08-06 2014-11-05 周思瑶 Vitality-tonifying health-preserving preparation and preparation method thereof
CN104127699B (en) * 2014-08-06 2018-04-13 周思瑶 Beneficial member health preparation and preparation method thereof
CN105726622A (en) * 2014-12-08 2016-07-06 中国人民解放军第二军医大学 Anti-fatigue traditional Chinese medicine combined extract and its preparation method and use
CN104397710A (en) * 2014-12-12 2015-03-11 香格里拉县天丽斯生物科技发展有限公司 Composition capable of improving fatigue condition
CN106107294A (en) * 2016-07-16 2016-11-16 成都圣弘源生物科技有限公司 A kind of compound recipe plateau hippophae rhamnoides beverage and preparation method thereof
CN107223966A (en) * 2017-05-09 2017-10-03 新疆生命核力高科股份有限公司 It is a kind of to be used to improve sweet oral liquid of Rong's grass of immunity and preparation method thereof
CN107223966B (en) * 2017-05-09 2020-11-06 新疆生命核力高科股份有限公司 Roxburgh rose and licorice oral liquid for improving immunity and preparation method thereof

Similar Documents

Publication Publication Date Title
CN103251867B (en) Chinese herbal compound medicine for treating diabetes mellitus and preparation method thereof
CN103719498B (en) A kind of Siberian solomonseal rhizome health-care tea improving immunity and preparation method thereof
CN103493941B (en) A kind of Weight-reducing health-care tea and preparation method thereof
CN102423443B (en) Double-formula medicine used for treating insomnia, and preparation method thereof
CN101695328B (en) Dendrobium tea
CN102949618A (en) Multifunctional diet tea
CN104547534A (en) Chinese herbal medicine health oral liquid with efficacy of relieving visual fatigue
CN102258734B (en) Cartialgenous wine having antifatigue and immunity-regulating effects and preparation method thereof
CN103372103A (en) Traditional Chinese medicine health-care tea and preparation method thereof
CN102178867B (en) Chinese medicine preparation for replenishing qi to invigorate spleen and tonifying kidney and products thereof
CN103721045B (en) For improving the Chinese traditional immunopoteniators of broiler immunologic function in growth course
CN104388265B (en) A kind of kidney-nourishing health tonic wine and preparation method thereof
CN103007216A (en) Chinese medicinal composition for treating chronic diarrhea
CN103550495B (en) A kind of Chinese medicine composition of Cure for insomnia
CN101934052B (en) Medicament for treating facial chloasma and preparation method thereof
CN103027138B (en) Tea for enlivening spleens and production method of tea
CN103432545B (en) A kind of medicine for pediatrics febricide and preparation method thereof
CN102115707B (en) Health wine and preparation process thereof
CN103520505B (en) Traditional Chinese medicine preparation for treating neurasthenia and preparation method thereof
CN101804165A (en) Preparation for clearing nephrotoxicity, strengthening internal organs, enhancing physique and preventing aging and preparation method thereof
CN103719497A (en) Gynostemma pentaphylla fat-reducing and weight-losing health-care tea and preparation method thereof
CN104958427A (en) Traditional Chinese medicine used for treating dysmenorrhea caused by qi and blood deficiency
CN101559195B (en) Epilepsy therapy capsule and preparation method thereof
CN102165983A (en) Mixed herb tea
CN103989818A (en) Medicinal liquor

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20121226