CN107137583B - Compound Chinese medicine preparation for treating anemia caused by yin deficiency and blood deficiency and its preparing process - Google Patents
Compound Chinese medicine preparation for treating anemia caused by yin deficiency and blood deficiency and its preparing process Download PDFInfo
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
A Chinese medicinal compound preparation for treating anemia due to yin deficiency and blood deficiency and its preparation method are provided. The preparation is prepared from the following medicinal raw materials in parts by weight: 12-32 parts of radix rehmanniae recen, 9-24 parts of Chinese yam, 6-15 parts of dogwood, 9-24 parts of rhizoma anemarrhenae, 9-24 parts of radix scrophulariae, 9-24 parts of radix ophiopogonis, 6-15 parts of cortex phellodendri, 6-15 parts of angelica sinensis, 9-24 parts of fried radix paeoniae alba, 6-15 parts of moutan bark, 6-15 parts of radix polygonati officinalis and 4-10 parts of raw liquorice. The preparation of the invention adopts a water boiling extraction method to extract the effective components in the raw material medicaments and keep the activity of the effective components, thus not only improving the dissolution rate of the effective components in the medicaments, but also being beneficial to the absorption of the medicaments, thereby improving the bioavailability of the medicaments. In addition, the medicine is a pure Chinese herbal compound preparation, so that the medicine does not generate toxic or side effect after being taken by a patient for a long time, and has good safety. In addition, the preparation method of the invention has simple process and convenient operation.
Description
Technical Field
The invention relates to a Chinese medicinal preparation and a preparation method thereof, in particular to a Chinese medicinal compound preparation which is prepared from Chinese medicaments serving as raw materials and is used for treating anemia caused by yin deficiency and blood deficiency and a preparation method thereof.
Background
Anemia refers to a peripheral blood unit volume blood with hemoglobin (Hb) concentration, Red Blood Cell (RBC) count, and Hematocrit (HCT) below the lower limits of normal for comparable populations, with hemoglobin being the most important. Anemia belongs to the categories of consumptive disease, yellow disease, deficient yellow disease and the like in the traditional Chinese medicine, and is mainly caused by spleen and kidney deficiency caused by congenital endowment deficiency, improper diet, long-term blood loss, excessive fatigue, malnutrition in pregnancy, deficiency and damage caused by long-term illness and the like, spleen deficiency causes transport and transformation failure, qi and blood are generated and generated passively, kidney deficiency causes deficiency of vital essence and qi, and qi and blood are not generated to transform blood into marrow, so that deficiency of qi and blood is caused. Although the varieties of the drugs clinically used for treating the anemia are many at present, the anemia is also divided into various types due to various factors causing the anemia, so the drugs lack pertinence, the treatment course is relatively long, and part of the drugs have certain side effects or anaphylactic reactions, so the effect of treating the anemia disease caused by yin deficiency and blood deficiency after taking the drug is not ideal.
Disclosure of Invention
In order to solve the problems, the invention aims to provide a traditional Chinese medicine compound preparation for treating anemia caused by yin deficiency and blood deficiency and a preparation method thereof.
In order to achieve the purpose, the traditional Chinese medicine compound preparation for treating anemia caused by yin deficiency and blood deficiency provided by the invention is prepared from the following medicine raw materials in parts by weight:
dried rehmannia root 12-32 Chinese yam 9-24 cornus officinalis 6-15 anemarrhena rhizome 9-24
Radix scrophulariae 9-24, radix ophiopogonis 9-24, cortex phellodendri 6-15, angelica sinensis 6-15, fried white paeony root 9-24
Moutan bark 6-15, polygonatum 6-15, licorice root 4-10
The preparation method of the traditional Chinese medicine compound preparation for treating the anemia caused by yin deficiency and blood deficiency comprises the steps of weighing and mixing the raw materials according to the proportion, then adding water to soak for 25 minutes, then decocting for 30 minutes, and filtering to remove residues to obtain the traditional Chinese medicine compound preparation for treating the anemia caused by yin deficiency and blood deficiency.
The Chinese medicinal compound preparation can be prepared into granules, tablets, capsules, syrups, oral liquids, pills and paste together with common pharmaceutic adjuvants.
The traditional Chinese medicine compound preparation for treating anemia caused by yin deficiency and blood deficiency provided by the invention adopts a water boiling extraction method to extract the effective components in the raw material medicines and keep the activity of the effective components, so that the dissolution rate of the effective components in the medicines is greatly improved, the absorption of the medicines is facilitated, and the bioavailability of the medicines is improved. In addition, the medicine is a pure Chinese herbal compound preparation, so that the medicine does not generate toxic or side effect after being taken by a patient for a long time, and has good safety. In addition, the preparation method of the invention has simple process and convenient operation.
Detailed Description
Anemia has complex symptoms, prolonged course of disease and more complications. Clinically, deficiency syndrome, excess syndrome and syndrome of intermingled deficiency and excess are common. The method is used for strengthening the spleen and stomach, and replenishing qi and generating blood. In the formula, raw rehmannia root, radix rehmanniae is sweet, bitter and cold in flavor, can clear heat and cool blood, nourish yin and promote the production of body fluid, is the essential drug for clearing heat, cooling blood and stopping bleeding, and is the monarch drug. The Chinese yam is sweet and neutral, can tonify spleen and nourish stomach, and is a good product for regulating and tonifying spleen and stomach in chronic persistent diseases; rhizoma anemarrhenae is bitter, sweet and cold, clears heat and purges fire, promotes the production of body fluid and moistens dryness; radix Ophiopogonis is sweet, slightly bitter, slightly cold, and has effects in nourishing yin, promoting salivation, moistening lung, and clearing away heart-fire; the angelica sinensis is sweet, pungent and warm, and has the effects of enriching blood, promoting blood circulation and relieving pain; the moutan bark, cortex moutan is bitter, sweet and slightly cold, has the effects of clearing heat and cooling blood, activating blood and removing stasis, and is a ministerial drug which has the effects of clearing heat and nourishing yin, activating blood and enriching blood, and tonifying spleen and qi. Cornus officinalis is sour, astringent and warm, has the effects of tonifying liver and kidney, astringing and inducing astringency, and is the essential drug for balancing yin and yang; radix scrophulariae is sweet, bitter, salty and slightly cold, and has the effects of clearing heat, cooling blood, purging fire, removing toxicity and nourishing yin; cortex Phellodendri is bitter and cold, and has effects of clearing heat and eliminating dampness, purging pathogenic fire and removing steam, removing toxic substance and treating sore; parched radix Paeoniae alba is slightly cold in bitter acid, and has effects of nourishing blood, astringing yin, softening liver, relieving pain, and suppressing liver yang; yuzhu is sweet and slightly cold, has the effects of nourishing yin, moistening dryness, promoting fluid production and quenching thirst, and is an adjuvant drug for clearing heat, eliminating dampness, nourishing yin, promoting fluid production, nourishing liver and kidney and tonifying yin and yang. Raw licorice root, radix Glycyrrhizae Praeparata, is sweet and neutral in nature, and has the effects of invigorating the spleen, replenishing qi, clearing away heat and toxic material, relieving pain, and harmonizing the effects of the other drugs in the recipe. The formula has the effects of tonifying spleen and kidney, nourishing yin and yang and generating qi and blood, so that the traditional Chinese medicine is suitable for treating anemia caused by yin deficiency and hemophthisis.
The following will explain the compound Chinese medicine preparation for treating anemia caused by yin deficiency and blood deficiency and the preparation method thereof in detail by combining the examples.
Example 1:
the compound traditional Chinese medicine preparation for treating anemia caused by yin deficiency and blood deficiency provided by the embodiment is prepared from the following raw materials in parts by weight:
dried rehmannia root, rhizome of common yam, 9 dogwood fruit, 6 anemarrhena rhizome, 9
Radix scrophulariae 9, radix ophiopogonis 9, cortex phellodendri 6, angelica sinensis 6, fried white paeony root 9
Cortex moutan 6, rhizoma Polygonati Odorati 6 and radix Glycyrrhizae 4
The preparation method of the traditional Chinese medicine compound preparation for treating the anemia caused by yin deficiency and blood deficiency comprises the steps of weighing and mixing the raw materials according to the proportion, then adding water to soak for 25 minutes, then decocting for 30 minutes, and filtering to remove residues to obtain the traditional Chinese medicine compound preparation for treating the anemia caused by yin deficiency and blood deficiency.
The Chinese medicinal compound preparation can be prepared into granules, tablets, capsules, syrups, oral liquids, pills and paste together with common pharmaceutic adjuvants.
Example 2:
the compound traditional Chinese medicine preparation for treating anemia caused by yin deficiency and blood deficiency provided by the embodiment is prepared from the following raw materials in parts by weight:
dried rehmannia root, rhizoma dioscoreae, 24 cornus officinalis, 15 anemarrhena asphodeloides bunge 24
Radix scrophulariae 24, radix ophiopogonis, 24 golden cypress, 15 Chinese angelica and 15 fried white paeony root 24
Moutan bark 15, fragrant solomonseal rhizome 15, raw licorice root 10
The preparation method is the same as example 1.
Example 3:
the compound traditional Chinese medicine preparation for treating anemia caused by yin deficiency and blood deficiency provided by the embodiment is prepared from the following raw materials in parts by weight:
dried rehmannia root, radix rehmanniae 22, yam, 17, dogwood, 12, rhizoma anemarrhenae, 17
Figwort root 17, ophiopogon root 17, phellodendron bark 12, angelica 12, fried white peony root 17
Moutan bark 12, fragrant solomonseal rhizome 12 and raw licorice root 108
The preparation method is the same as example 1.
The traditional Chinese medicine compound preparation for treating anemia caused by yin deficiency and blood deficiency provided by the invention is brown to tan; light smell, slightly bitter taste. In order to verify the treatment effect of the traditional Chinese medicine compound preparation, the inventor carries out systematic clinical observation on 315 patients suffering from anemia due to yin deficiency and blood deficiency by using the traditional Chinese medicine compound preparation, wherein 99 patients of 21-30 years old, 114 patients of 31-40 years old and 102 patients of 41-50 years old take 150ml of the traditional Chinese medicine compound preparation every time, 3 times are taken every day, and 1 treatment course is 120 days. 199 total cure cases (main symptoms such as hemoglobin (Hb) concentration, Red Blood Cell (RBC) count and Hematocrit (HCT)) are obviously improved after 1 treatment course, and the total cure amount accounts for 63.2 percent; 99 effective cases (obviously improved in various tests and main symptoms) account for 31.4 percent; 17 cases of ineffectiveness (no change in each test examination, no improvement in chief symptoms) account for 5.4%; the total effective rate is 94.6%. 246 cases of the Chinese medicinal composition are cured after 2 courses of treatment, accounting for 78.1 percent; 60 effective cases account for 19.0 percent; ineffective 9 cases, accounting for 2.9%; the total effective rate is 97.1%.
Meanwhile, the inventor analyzes the relationship between the treatment effect and the age and the relationship between the treatment effect and the treatment course, and the analysis results are respectively shown in tables 1 and 2.
Table 1: the relation table between the treatment effect and the age of the traditional Chinese medicine compound preparation provided by the invention
The data in Table 1 above are expressed as x2The test method calculates that the result is 0.050 > P > 0.025, so that the treatment effect of the traditional Chinese medicine compound preparation for treating the yin-deficiency and blood-deficiency anemia provided by the invention on all age groups can be proved to be not changed along with the ages.
Table 2: the relation table of the treatment effect and the treatment course of the traditional Chinese medicine compound preparation provided by the invention
The data in Table 2 above are expressed as x2The result of calculation by an inspection method is that P is less than 0.005, so that the curative rate and the effective rate are obviously improved along with the deep treatment when the traditional Chinese medicine compound preparation provided by the invention is taken to treat the anemia with the deficiency of yin and blood.
Claims (3)
1. A traditional Chinese medicine compound preparation for treating anemia caused by yin deficiency and blood deficiency is characterized in that: the traditional Chinese medicine compound preparation for treating anemia caused by yin deficiency and blood deficiency is prepared from the following raw materials in parts by weight:
dried rehmannia root 12-32 Chinese yam 9-24 cornus officinalis 6-15 anemarrhena rhizome 9-24
Radix scrophulariae 9-24, radix ophiopogonis 9-24, cortex phellodendri 6-15, angelica sinensis 6-15, fried white paeony root 9-24
6-15 parts of moutan bark, 6-15 parts of polygonatum odoratum and 4-10 parts of raw liquorice.
2. A method for preparing the compound Chinese medicinal preparation for treating anemia caused by yin deficiency and blood deficiency as claimed in claim 1, wherein the method comprises the following steps: the preparation method comprises the steps of weighing and mixing the raw materials according to the proportion, then adding water to soak for 25 minutes, then decocting for 30 minutes, filtering and removing slag to prepare the traditional Chinese medicine compound preparation for treating anemia caused by yin deficiency and blood deficiency.
3. The method of claim 2, wherein: the Chinese medicinal compound preparation and common pharmaceutical excipients are prepared into granules, tablets, capsules, syrups, oral liquid, pills or paste.
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Non-Patent Citations (1)
| Title |
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| 辨证治疗慢性再生障碍性贫血63例;刘淑芳等;《实用中医药杂志》;19971231(第3期);第3页左栏治疗方法部分第3段 * |
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