CN105832881A - Preparation method of donkey-hide gelatin Chinese angelica blood-nourishing composition and application thereof - Google Patents
Preparation method of donkey-hide gelatin Chinese angelica blood-nourishing composition and application thereof Download PDFInfo
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- CN105832881A CN105832881A CN201510020034.1A CN201510020034A CN105832881A CN 105832881 A CN105832881 A CN 105832881A CN 201510020034 A CN201510020034 A CN 201510020034A CN 105832881 A CN105832881 A CN 105832881A
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Abstract
The invention discloses a preparation method of a donkey-hide gelatin Chinese angelica blood-nourishing composition and application thereof. The composition takes rare traditional Chinese medicines Chinese angelica and donkey-hide gelatin as the monarch drugs, adopts prepared rehmannia root and white paeony root as the minister drugs, employs Codonopsis pilosula, Poria cocos, astragalus and Ligusticum wallichii as the assistant drugs, and uses baked licorice as the guide drug, all the materials are coordinated according to monarch, minister, assistant and guide and interact to form the composition. On the basis of classical qi-benefiting and blood-nourishing formula "Decoction of Four Drugs" and "Decoction of four Noble Drugs", "upgrading" is carried out in the invention, according to the theory of traditional Chinese medicine, the prescription is reasonably optimized, Ligusticum wallichii, Poria cocos and baked licorice are added, starting from the foundation of human body, the composition replenishes blood, at the same time has the efficacy of activating blood circulation, invigorating qi, tonifying spleen and benefiting absorption, thus reaching the effects of tonifying qi and blood and yielding twice the result with half the effort. The formula is formed according to the modern scientific concept, can prevent weight increase and other side effects during taking of tonic drugs at the same time of effective treatment of anemia. The invention adopts all pure natural drugs, the drugs are purified to retain effective components and activity, are highly concentrated, and can achieve lasting efficacy, the composition solves the problem of slow curative effect of blood-nourishing and complexion improving products, and is a blood-nourishing, beauty maintaining and menstruation regulating drug really suitable for women to take orally. Being a clinically popular, safe, stable and effective gynecological drug, the composition is widely applicable in modern traditional Chinese medicine enterprises.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to the preparation method and applications of a kind of EGUIYANGXUE compositions.
Background technology
'Aguiyangxue ' is the Chinese patent medicine of a kind of classics, mainly has the effects such as benefiting qi and nourishing blood, and for deficiency of qi and blood, shallow complexion, dizziness is weak, wasting, amenorrhea, the inferior disease of red and white leukorrhea.'Aguiyangxue ' is gynecological's good medicine, through clinical trial certificate for many years, really has blood nourishing body building, along the remarkable efficacy through nourishing.Said composition, with rare Chinese medicine Radix Angelicae Sinensis, Colla Corii Asini as monarch drug, with Radix Rehmanniae Preparata, white peony root is used as ministerial medicine, with Radix Codonopsis, Poria, the Radix Astragali, Rhizoma Chuanxiong as adjuvant drug, with Radix Glycyrrhizae Preparata for making medicine, matches by monarch, and effect each other forms.To physical weakness, emaciation and sallow complexion, after being ill anemia, women's menses is not normal, letter phase stomachache, has a dizzy spell, puerperal the illness such as anemia, curative effect is the most distinguished, often takes and has to moisten and send out a skin, promotes radiant, the function that the youth is resident.
EGUIYANGXUE compositions side solves: monarch drug Colla Corii Asini has the effect enriched blood, invigorate blood circulation and stop blooding, Radix Angelicae Sinensis has replenishing and activating blood, menstruction regulating and pain relieving, tonifying five ZANG-organs, the effect of granulation promoting meat, in addition with effect of pool face skin moistening, in terms of women's health, play extremely important role.Ministerial drug Radix Rehmanniae Preparata has nourishing YIN and supplementing blood, benefit essence fills out the effect of marrow, can do with women green around the gills, have a dizzy spell, menoxenia, the enriching blood of Radix Angelicae Sinensis, curative effect of invigorating blood circulation can also be strengthened with Radix Angelicae Sinensis compatibility.Radix Paeoniae Alba essentials of Matea Medica is called it and is enriched blood, eliminating pathogen in the liver, strengthening the spleen, holds back liver-yin, controls the stomachache of blood deficiency.Tang Materia Medica is said its " benefit woman's blood ", modern Chinese medicine think it can nourishing blood to suppress the hyperactive liver, menoxenia is had good curative effect.Adjuvant drug Radix Codonopsis, the Radix Astragali two medicine by QI invigorating with hemopoietic, i.e. so-called: kind nourishing YIN person, must treating YIN within YANG.Poria spleen invigorating, i.e. the spleen governs the blood, the meaning of spleen hemopoietic.Rhizoma Chuanxiong energy blood circulation promoting and blood stasis dispelling, has circulation of qi promoting effect concurrently, and its property is wandered away, and the analogy of the assistant mother with gas as blood, blood is the general of gas, gas row then blood, the stagnation of QI then blood stasis, the most greasy with the taste of row Radix Rehmanniae Preparata, Ah returning.Make medicine Radix Glycyrrhizae Preparata have the mediation property of medicine, borrow the sweet warm nature of Radix Glycyrrhizae to put down simultaneously, vigorate qi and replenish the blood, contribute to enriching blood.
Summary of the invention
The present invention is to carry out " upgrading " on the basis of classical vigorate qi and replenish the blood side's " SIWU TANG " and " decoction of four noble drugs ", according to Traditional Chinese medical theory, reasonably optimizing prescription, add and used Rhizoma Chuanxiong, Poria, Radix Glycyrrhizae Preparata three taste Chinese medicine, at all starting with from human body, while enriching blood, air making-up and spleen enlivening benefit of invigorating blood circulation absorbs, thus the effect having reached qi and blood tonifying, having got twice the result with half the effort.Carry out formula according to modern science theory, when preventing and take nourishing class medicine while effectively treatment anemia, the side effect such as body weight increase occur.Use international state-of-the-art production technology, improve quality and the curative effect of medicine.All use pure natural medical materials, purify and remain with effective constituent and activity, high enrichment, lasting medicine, solving the problem that the profit face product curative effect that nourishes blood is slow, be a kind of real to be suitable for the blood-enriching face-nourishing emmenagogue that women takes.Deep by clinic welcome, gynecological safe and stable, effective medicine, it is widely used in modern Chinese medicine enterprise.
A kind of EGUIYANGXUE compositions provided by the present invention is with rare Chinese medicine Radix Angelicae Sinensis 200-2000g, Colla Corii Asini 10-200g, and help with Radix Codonopsis 10-200g, Radix Paeoniae Alba 10-200g, Poria 10-200g, Radix Astragali 10-200g, Radix Rehmanniae Preparata 10-200g, Radix Glycyrrhizae (honey moxibustion) all medicines of 4-20g, Rhizoma Chuanxiong 4-20g, major-minor matching, effect each other is made to form.
Adjuvant used by the present invention can be sucrose, lactose, Mel, starch, magnesium stearate, sodium benzoate, beta-schardinger dextrin-, HP-β-CD, microcrystalline Cellulose, hydroxypropyl cellulose, carboxymethylstach sodium, Aspartane, polyvinylpolypyrrolidone, PVP K30 one or more be used in mixed way.
The application of a kind of EGUIYANGXUE compositions of the present invention can be any one in the oral solid formulations such as pill, syrup, granule, capsule, unguentum.
A kind of EGUIYANGXUE compositions of the present invention is to carry out " upgrading " on the basis of traditional prescription of enriching blood, adding and used Rhizoma Chuanxiong, Poria, Radix Glycyrrhizae Preparata three taste Chinese medicine, at all starting with from human body, while enriching blood, air making-up and spleen enlivening benefit of invigorating blood circulation absorbs, thus the effect having reached qi and blood tonifying, having got twice the result with half the effort.Carry out formula according to modern science theory, when preventing and take nourishing class medicine while effectively treatment anemia, the side effect such as body weight increase occur.All use pure natural medical materials, purify and remain with effective constituent and activity, high enrichment, lasting medicine, solving the problem that the profit face product curative effect that nourishes blood is slow, be a kind of real to be suitable for the blood-enriching face-nourishing emmenagogue that women takes.Deep by clinic welcome, gynecological safe and stable, effective medicine, it is widely used in modern Chinese medicine enterprise.
Detailed description of the invention embodiment 1: the formula composition Radix Angelicae Sinensis 756g Colla Corii Asini 48g of donkey hide gelatin and Chinese angelica nourishing blood pill
Radix Codonopsis 48g Radix Paeoniae Alba 48g
Poria 48g Radix Astragali 48g
Radix Rehmanniae Preparata 48g Radix Glycyrrhizae (honey moxibustion) 20g
Rhizoma Chuanxiong 20g right amount of auxiliary materials.
Donkey hide gelatin and Chinese angelica nourishing blood pill preparation technology: cleaned respectively by nine taste medicines, removes impurity, checks qualified standby.It is standby that Colla Corii Asini is ground into fine powder；The eight taste medicated powder such as remaining Radix Angelicae Sinensis are broken into coarse powder, use 60% ethanol as solvent, impregnate 24 hours, slowly percolation, collect 8 times amount and filter liquid, reclaim ethanol, are concentrated into appropriate, after standing, collect the grease floated, and another device preserves；Medicinal residues boiling 1 time, 1 hour time, filters, and filtrate is concentrated in right amount, stands 24 hours.Incline and take above two concentrated medicament, mixing, add with the Colla Corii Asini solution after water-solubleization, stir evenly, boil 30 minutes, filter while hot, it is concentrated into relative density 1.08-1.10 (55-60 DEG C), spray drying makes dried cream powder, adds above-mentioned donkey-hide gelatin fine powder, appropriate amount of auxiliary materials mixing, pill, it is dried, spray adds above-mentioned grease, mixing, to obtain final product.
Embodiment 2: the formula composition Radix Angelicae Sinensis 257g Colla Corii Asini 16g of Aguiyangxue granules
Radix Codonopsis 16g Radix Paeoniae Alba 16g
Poria 16g Radix Astragali 16g
Radix Rehmanniae Preparata 16g Radix Glycyrrhizae (honey moxibustion) 8g
Rhizoma Chuanxiong 8g right amount of auxiliary materials.
Aguiyangxue granules preparation technology: take in prescription in addition to Colla Corii Asini, eight tastes such as remaining Radix Angelicae Sinensis use 60% ethanol percolate extraction, diacolation liquid recycling ethanol, are concentrated into appropriate, stand, collect the grease floated；Medicinal residues water concentration is reduced to appropriate and above-mentioned concentrated solution mixing, adds the Colla Corii Asini solution dissolved, boils, filter, concentrates, and with sucrose, dextrin granulation, dry, spray adds above-mentioned grease, mixing, and granule subpackage to obtain final product.
Embodiment 3: the formula composition Radix Angelicae Sinensis 360g Colla Corii Asini 24g of EGUIYANGXUE capsule
Radix Codonopsis 24g Radix Paeoniae Alba 24g
Poria 24g Radix Astragali 24g
Radix Rehmanniae Preparata 24g Radix Glycyrrhizae (honey moxibustion) 12g
Rhizoma Chuanxiong 12g right amount of auxiliary materials,.
EGUIYANGXUE capsules preparation technique: take in prescription in addition to Colla Corii Asini, eight tastes such as remaining Radix Angelicae Sinensis use 60% ethanol percolate extraction, diacolation liquid recycling ethanol, it is concentrated into appropriate, stands, collect the grease floated and with cyclodextrin inclusion compound, medicinal residues water concentration is reduced to appropriate and above-mentioned concentrated solution mixing, adds the Colla Corii Asini solution dissolved, boils, filter, concentrate, add starch, sucrose wet granular, being dried, spray adds above-mentioned cyclodextrin clathrate, adds magnesium stearate mix homogeneously, capsule machine filling, to obtain final product.
Embodiment 4: the formula composition Radix Angelicae Sinensis 275g Colla Corii Asini 25g of EGUI YANGXUE TANGJIANG
Radix Codonopsis 18g Radix Paeoniae Alba 18g
Poria 18g Radix Astragali 18g
Radix Rehmanniae Preparata 18g Radix Glycyrrhizae (honey moxibustion) 10g
Rhizoma Chuanxiong 10g right amount of auxiliary materials.
EGUI YANGXUE TANGJIANG preparation technology: take in prescription in addition to Colla Corii Asini, eight tastes such as remaining Radix Angelicae Sinensis use 60% ethanol percolate extraction, diacolation liquid recycling ethanol, it is concentrated into appropriate, stands, collect the grease floated, medicinal residues water concentration is reduced to appropriate and above-mentioned concentrated solution mixing, adds the Colla Corii Asini solution dissolved, boils, filter, concentrate, add in sucrose, appropriate boiling distilled water, heated and stirred make molten after, add soluble agents, dissolution filter, from filter, add appropriate distilled water to specified volume and get final product.
Embodiment 5: the formula composition Radix Angelicae Sinensis 2000g Colla Corii Asini 200g of EGUIYANGXUE cream
Radix Codonopsis 180g Radix Paeoniae Alba 180g
Poria 180g Radix Astragali 180g
Radix Rehmanniae Preparata 180g Radix Glycyrrhizae (honey moxibustion) 16g
Rhizoma Chuanxiong 16g right amount of auxiliary materials.
EGUIYANGXUE cream preparation technology:
Soak: after the eight tastes mixing such as qualified decoction pieces is checked in selection, takes in prescription in addition to Colla Corii Asini, remaining Radix Angelicae Sinensis, add the water soaking 20～60min of compound gross weight 8～12 times；(2) decoct: after first boiling with big fire, turn firepower down and make it keep micro-boiling 1～3h, filter, collect filtrate；Adding compound gross weight 8～the cold water of 12 times in filtering residue, decocting method is with for the first time；(3) concentrate: merge the filtrate of twice decoction, be evaporated to relative density 1.08-1.10 with concentrator；(4) allotment: the water heating adding Colla Corii Asini amount 2～5 times makes Colla Corii Asini dissolve completely；Colla Corii Asini is added in respective concentrated solution with Mel and mixes, continue to be concentrated to give paste nourishing agent.
Claims (4)
1. the preparation method and applications of an EGUIYANGXUE compositions, it is characterized in that: said composition is auxiliary based on rare Chinese medicine Radix Angelicae Sinensis 200-2000g, Colla Corii Asini 10-200g, and help with Radix Codonopsis 10-200g, Radix Paeoniae Alba 10-200g, Poria 10-200g, Radix Astragali 10-200g, Radix Rehmanniae Preparata 10-200g, Radix Glycyrrhizae (honey moxibustion) 4-20g, the all medicines of Rhizoma Chuanxiong 4-20g, make major-minor matching, effect each other form.
The preparation method and applications of a kind of EGUIYANGXUE compositions the most according to claim 1, it is characterised in that: adjuvant used can be sucrose, lactose, Mel, starch, magnesium stearate, sodium benzoate, beta-schardinger dextrin-, HP-β-CD, microcrystalline Cellulose, hydroxypropyl cellulose, carboxymethylstach sodium, Aspartane, polyvinylpolypyrrolidone, PVP K30 one or more be used in mixed way.
The preparation method and applications of a kind of EGUIYANGXUE compositions the most according to claim 1, it is characterised in that: its application can be any one in the oral solid formulations such as pill, syrup, granule, capsule, unguentum.
The preparation method and applications of a kind of EGUIYANGXUE compositions the most according to claim 1, it is characterized in that: said composition is to carry out " upgrading " on the basis of traditional prescription of enriching blood, add and used Rhizoma Chuanxiong, Poria, Radix Glycyrrhizae Preparata three taste Chinese medicine, at all starting with from human body, while enriching blood, air making-up and spleen enlivening benefit of invigorating blood circulation absorbs, thus the effect having reached qi and blood tonifying, having got twice the result with half the effort, carry out formula according to modern science theory, when preventing and take nourishing class medicine while effectively treatment anemia, the side effect such as body weight increase occur.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106213503A (en) * | 2016-08-16 | 2016-12-14 | 唐莎 | A kind of beauty face-whitening-nourishing medicated diet |
| CN109157582A (en) * | 2018-11-28 | 2019-01-08 | 江西济民可信金水宝制药有限公司 | A kind of Aguiyanxue Syrup and preparation method thereof |
| CN109662310A (en) * | 2017-10-17 | 2019-04-23 | 陶清建 | A kind of maternal nutritional product and preparation method thereof |
| CN109692232A (en) * | 2017-10-23 | 2019-04-30 | 康普药业股份有限公司 | A kind of extracting method of Aguiyangxue granules |
-
2015
- 2015-01-15 CN CN201510020034.1A patent/CN105832881A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106213503A (en) * | 2016-08-16 | 2016-12-14 | 唐莎 | A kind of beauty face-whitening-nourishing medicated diet |
| CN109662310A (en) * | 2017-10-17 | 2019-04-23 | 陶清建 | A kind of maternal nutritional product and preparation method thereof |
| CN109692232A (en) * | 2017-10-23 | 2019-04-30 | 康普药业股份有限公司 | A kind of extracting method of Aguiyangxue granules |
| CN109157582A (en) * | 2018-11-28 | 2019-01-08 | 江西济民可信金水宝制药有限公司 | A kind of Aguiyanxue Syrup and preparation method thereof |
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