CN104825644B - Chinese medicinal preparation for treating leukemia - Google Patents
Chinese medicinal preparation for treating leukemia Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine preparation for treating leukemia and a preparation method thereof. The traditional Chinese medicine preparation for treating leukemia is prepared from the following raw materials in parts by weight: 100-120 parts of lemongrass, 50-60 parts of honeysuckle, 50-60 parts of oldenlandia diffusa, 40-60 parts of barbed skullcap herb, 15-20 parts of radix scrophulariae, 15-20 parts of liquorice, 100-120 parts of angelica, 20-30 parts of donkey-hide gelatin, 10-20 parts of lotus root starch and 5-10 parts of sugar powder. The traditional Chinese medicine composition has multiple action targets of the medicine components, and the components have synergistic action, and pharmacological experiments show that the traditional Chinese medicine composition has the effect of remarkably reducing toxic and side effects in the chemical medicine treatment process, and has a good leukemia inhibition effect on leukemia cells. Compared with the prior art, the method has the following advantages: is a natural pure Chinese medicinal preparation, has no toxic or side effect, short curative effect, quick response, difficult relapse, simple prescription, high cure rate and obvious curative effect on treating leukemia, and has obvious clinical popularization and application values, and the total effective rate reaches 99%.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating leukemia and a preparation method thereof.
Background
Leukemia is malignant leukemia of hematopoietic system which seriously jeopardizes human life and health, and is a kind of malignant disease originated from hematopoietic (or lymphatic) stem cells. The leukemia cells lose the capacity of further differentiation and maturation or the capacity of proliferation and differentiation are unbalanced and stop at different stages of cell development due to the damaged stem cells, which is characterized in that the cells have unlimited proliferation in vivo and are hindered in differentiation and maturation and apoptosis. Thus, treatment of leukemia can be initiated from three aspects: inducing cell apoptosis, inducing cell differentiation and stem cell transplantation to restore hematopoiesis. The leukemia is treated mainly by the traditional combined chemotherapy so far, but the therapy has large side effect and high recurrence rate, particularly has large damage to the immune and hematopoietic systems of the organism, kills cancer cells and damages red blood cells and white blood cells, and patients are bitter.
In order to avoid operation pain and high operation cost, the traditional Chinese medicine is generally accepted by patients, traditional Chinese medicines can relieve adverse reactions caused by chemotherapy to a certain extent, a traditional Chinese medicine preparation for treating leukemia is reported in documents, but the formula is complex, the traditional Chinese medicine is composed of more than 15 medicines or even more than 30 medicines, the cost is high, the medicine property is too strong, some medicinal materials are not easy to obtain, some compound medicines have large side effects, the cure rate is not high, and the disease is easy to relapse. In order to meet the requirements of patients, the improvement of the traditional Chinese medicine preparation for treating leukemia is urgently needed, which is not only beneficial to the treatment of patients, but also more important, is beneficial to the protection of the Chinese treasure-the traditional Chinese medicine preparation.
Disclosure of Invention
Aiming at the defects of the existing traditional Chinese medicine preparation, the invention aims to provide the traditional Chinese medicine preparation for treating leukemia, which has simple formula, high cure rate and small side effect.
In order to realize the purpose of the invention, the technical scheme is as follows:
the traditional Chinese medicine preparation for treating leukemia is prepared from the following raw materials in parts by weight:
100-120 parts of lemongrass, 50-60 parts of honeysuckle, 50-60 parts of oldenlandia diffusa, 40-60 parts of barbed skullcap herb, 15-20 parts of radix scrophulariae, 15-20 parts of liquorice, 100-120 parts of angelica, 20-30 parts of donkey-hide gelatin, 10-20 parts of lotus root starch and 5-10 parts of sugar powder.
The preferable formula is as follows: 100 parts of Chinese ash, 60 parts of honeysuckle, 60 parts of spreading hedyotis herb, 60 parts of barbed skullcap herb, 15 parts of radix scrophulariae, 15 parts of liquorice, 100 parts of Chinese angelica, 20 parts of donkey-hide gelatin, 10 parts of lotus root starch and 5 parts of powdered sugar.
The preferable formula is as follows: 120 parts of Chinese milkvetch root, 50 parts of honeysuckle, 50 parts of spreading hedyotis herb, 40 parts of barbed skullcap herb, 20 parts of figwort root, 20 parts of liquorice, 120 parts of Chinese angelica, 30 parts of donkey-hide gelatin, 20 parts of lotus root starch and 5 parts of powdered sugar.
The preparation method comprises the following steps: soaking flos Lonicerae in clear water for several hours, distilling with steam to extract volatile oil, and collecting; soaking herba Lespedezae Cuneatae, herba Hedyotidis Diffusae, herba Scutellariae Barbatae, radix scrophulariae, Glycyrrhrizae radix, radix Angelicae sinensis, and colla Corii Asini in water for several hours, decocting for three times (1-2 hours for the first time), pouring out the filtrate, decocting for 45-60 minutes in water for the second and third times, mixing filtrates, filtering, concentrating the filtrate to 200ml, adding ethanol, stirring well, standing for several hours; then mixing with flos Lonicerae extract, concentrating to 200-.
The application and dosage are as follows: orally administered three times a day, 5g each time.
The invention adopts a hereditary formula, and the pharmacology is as follows: the herbs for clearing heat and removing toxicity, nourishing blood and stopping bleeding are selected to play a synergistic role.
Scutellaria barbata contains alkaloid, flavonoid glycoside, steroid, phenol, tannin, etc. The contained barbadoslily is a flavonoid compound (2, 5-dihydroxy-6, 7, 8-trimethoxyflavone), and in addition, the other two flavonoid compounds, namely the baicalein (5, 7-dihydroxy-8-methoxyflavone) and the 5-hydroxy-7, 8-dimethoxyflavone, have good anticancer effect, particularly have good inhibition effect on acute granulocyte leukemia cells, and can improve the symptoms of leukemia patients, inhibit tumor proliferation and prolong the life of the patients.
A Leimahui: promoting blood circulation, removing toxic substance and relieving pain; herba Hedyotidis Diffusae: clearing away heat and toxic materials, promoting blood circulation, promoting urination, enhancing immunity, and inhibiting growth of tumor cells;
radix scrophulariae: clearing away heat and toxic materials, and softening and resolving hard mass;
licorice root: contains multiple chemical components, the main components include glycyrrhizic acid, liquiritin and the like, and the glycyrrhizic acid, the liquiritin and the like are interferon inducers and cell immunomodulators, can clear away heat and toxic materials and can also enhance the immune function; the composition has the effects of clearing away heat and toxic materials, promoting blood circulation and dredging collaterals.
Chinese angelica: contains angelica polysaccharide, can enrich and activate blood, can increase the immune function of the organism and obviously improve the immune function.
E, donkey-hide gelatin: contains abundant collagen, has effects of nourishing yin and blood, improving body constitution, regulating immunity, and improving disease resistance of organism.
Lotus root starch: benefiting stomach, invigorating spleen, nourishing blood, and invigorating.
Honeysuckle flower: contains chlorogenic acid, luteolin glycoside, etc., and has effects in promoting phagocytic function of leukocyte, and enhancing immunity.
The innovation points of the invention are as follows: the Chinese medicinal composition is prepared from the Chinese medicinal herbs including the ledebouriella root, honeysuckle flower, oldenlandia, barbat skullcap, scrophularia and licorice root, and serves as a monarch drug for assisting in detoxifying, Chinese angelica and donkey-hide gelatin for nourishing blood and generating blood and supplementing deficient blood, and lotus root starch and powdered sugar as auxiliary materials for assisting in nourishing blood and stopping bleeding. The traditional Chinese medicine has the effects of tonifying deficiency and qi, enriching blood and replenishing essence and improving the immunity of human bodies, the traditional Chinese medicine composition has multiple action targets of the medicine components, and the components have synergistic action, and pharmacological experiments show that the traditional Chinese medicine composition has the effect of remarkably reducing toxic and side effects in the chemical medicine treatment process, and has a good effect of inhibiting leukemia of leukemia cells. Compared with the prior art, the method has the following advantages: the traditional Chinese medicine composition is a natural pure traditional Chinese medicine preparation, has no toxic or side effect, short curative effect, quick response, difficult recurrence, simple prescription, high cure rate and 99 percent of total effective rate, has obvious curative effect on treating leukemia, obviously improves the medication compliance of leukemia patients, accelerates the body recovery and provides guarantee for the body health of the patients. Has clinical popularization and application values.
In order to further examine the clinical efficacy of the medicine, 100 outpatient leukemia patients were selected for clinical trials, wherein 66 male patients and 34 female patients have the onset age of 20-70 years and the course of disease is 4 months-3 years. The treatment method comprises the following steps: the treatment groups were administered the Chinese medicinal preparations of examples 1-3 orally, three times a day, 5g once. Twenty days is a course of treatment, generally 2-4 courses of treatment are needed to achieve better effect, and pungent, spicy and greasy food, tea leaves and wine are avoided for patients during administration. After 3 courses of treatment, the treatment results were: 96 cases of significant effect account for 96 percent, 3 cases of effective effect account for 3 percent, and 1 case of ineffective effect accounts for 1 percent.
And (3) judging the curative effect:
the effect is shown: clinical symptoms (extreme tiredness, anorexia, nausea, vomiting, anorexia, alopecia, low fever, suppression of bone marrow hematopoiesis, bleeding and infection tendency, etc.) are substantially or mostly disappeared.
The method has the following advantages: the clinical symptoms are obviously improved.
And (4) invalidation: no change in clinical symptoms and signs.
The animal acute toxicity test is carried out on the traditional Chinese medicine preparation of the invention:
test animals: selecting a white mouse with the weight of 30-50g, and selecting male and female randomly;
the method comprises the following steps: 60 mice are taken and divided into 6 groups, each group comprises 10 mice, after 10 hours of hunger, 5-6g of the traditional Chinese medicine preparation (dissolved in water) is fed to each mouse, 4 times of feeding is carried out within 24 hours, and 7 days of observation show that the mice normally move without toxic reaction and die for no one case. The dosage of the white mouse is calculated according to the dosage of kilogram body weight, which shows that the traditional Chinese medicine preparation has no toxicity and safe clinical medication dosage.
Detailed Description
To better illustrate the invention, the following examples are given:
example 1
The traditional Chinese medicine preparation for treating leukemia is prepared from the following raw materials in parts by weight:
110 parts of Chinese ash, 55 parts of honeysuckle, 55 parts of spreading hedyotis herb, 45 parts of barbed skullcap herb, 15 parts of radix scrophulariae, 20 parts of liquorice, 110 parts of Chinese angelica, 25 parts of donkey-hide gelatin, 10 parts of lotus root starch and 10 parts of powdered sugar.
The preparation method comprises the following steps: soaking flos Lonicerae in clear water for 1 hr, distilling with steam to extract volatile oil, and collecting; soaking herba Lespedezae Cuneatae, herba Hedyotidis Diffusae, herba Scutellariae Barbatae, radix scrophulariae, Glycyrrhrizae radix, radix Angelicae sinensis, and colla Corii Asini in water for 1 hr, decocting for three times, decocting for 1 hr for the first time, pouring out the filtrate, decocting for 45 min with water for the second and third times, mixing filtrates, filtering, concentrating the filtrate to 200ml, adding ethanol, stirring, and standing for 12 hr; mixing with flos Lonicerae extract, concentrating to 200m, recovering ethanol, adding Amylum Nelumbinis Rhizomatis, sugar powder and adjuvants, and making into granule.
Example 2
The traditional Chinese medicine preparation for treating leukemia is prepared from the following raw materials in parts by weight:
100 parts of Chinese ash, 60 parts of honeysuckle, 60 parts of spreading hedyotis herb, 60 parts of barbed skullcap herb, 15 parts of radix scrophulariae, 15 parts of liquorice, 100 parts of Chinese angelica, 20 parts of donkey-hide gelatin, 10 parts of lotus root starch and 5 parts of powdered sugar.
The preparation method is the same as above.
Example 3
The traditional Chinese medicine preparation for treating leukemia is prepared from the following raw materials in parts by weight:
120 parts of Chinese milkvetch root, 50 parts of honeysuckle, 50 parts of spreading hedyotis herb, 40 parts of barbed skullcap herb, 20 parts of figwort root, 20 parts of liquorice, 120 parts of Chinese angelica, 30 parts of donkey-hide gelatin, 20 parts of lotus root starch and 5 parts of powdered sugar.
The preparation method is the same as above.
Typical cases
Case 1:
wangzhi, female, age 63, patient had no obvious inducement to epigastric pain, intermittent pain, no acid regurgitation, belching, black stool and molding before 6 months. Emaciation was evident in half a year. The effect of self-taking stomach medicine is not obvious. The doctor visits the doctor before. Blood tests show that acute monocytic leukemia is seriously vomited after chemotherapy treatment, accompanied with bleeding and fever tendency, and the traditional Chinese medicine disclosed by the invention is used for 20 days, so that the vomiting symptom disappears, the body temperature returns to normal, the bleeding tendency disappears, the food intake is good, and the recovery condition is better.
Case 2:
plum, male and 24 years old, have severe bone marrow hematopoietic function inhibition after operation and pale complexion due to the chemotherapy treatment of leukemia, and have symptoms of emesis, alopecia and low fever, and the traditional Chinese medicine has the advantages of disappearance of symptoms, good eating and no adverse reaction after being used for 40 days.
Claims (2)
1. The traditional Chinese medicine preparation for treating leukemia is characterized by being prepared from the following raw materials in parts by weight: 100 parts of Chinese ash, 60 parts of honeysuckle, 60 parts of spreading hedyotis herb, 60 parts of barbed skullcap herb, 15 parts of radix scrophulariae, 15 parts of liquorice, 100 parts of Chinese angelica, 20 parts of donkey-hide gelatin, 10 parts of lotus root starch and 5 parts of powdered sugar.
2. The traditional Chinese medicine preparation for treating leukemia according to claim 1, which is prepared from the following raw materials in parts by weight: 120 parts of Chinese milkvetch root, 50 parts of honeysuckle, 50 parts of spreading hedyotis herb, 40 parts of barbed skullcap herb, 20 parts of figwort root, 20 parts of liquorice, 120 parts of Chinese angelica, 30 parts of donkey-hide gelatin, 20 parts of lotus root starch and 5 parts of powdered sugar.
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| CN201510250320.7A CN104825644B (en) | 2015-05-18 | 2015-05-18 | Chinese medicinal preparation for treating leukemia |
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| CN107050175A (en) * | 2017-03-22 | 2017-08-18 | 郑百战 | It is a kind of to treat Chinese medicine preparation of vasculitis and preparation method thereof |
| CN106822764A (en) * | 2017-03-31 | 2017-06-13 | 天津市善济宏兴科技发展有限公司 | For treating the leukemogenic compound Chinese medicinal preparation of deficiency of spleen-QI and stomach-QI institute and preparation method |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101167865A (en) * | 2007-11-02 | 2008-04-30 | 王芬 | Orally-administered traditional Chinese medicinal composition for treating acute leukemia |
| CN104306803A (en) * | 2014-10-20 | 2015-01-28 | 山东省医学科学院基础医学研究所 | Traditional Chinese medicine composition for treating minimal residual leukemia |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101167865A (en) * | 2007-11-02 | 2008-04-30 | 王芬 | Orally-administered traditional Chinese medicinal composition for treating acute leukemia |
| CN104306803A (en) * | 2014-10-20 | 2015-01-28 | 山东省医学科学院基础医学研究所 | Traditional Chinese medicine composition for treating minimal residual leukemia |
Non-Patent Citations (2)
| Title |
|---|
| 中医对白血病的认识和治疗;张亭栋;《中医杂志》;19831231(第3期);第71-74页 * |
| 中医药治疗急性白血病的研究进展;郑丹丹等;《医学综述》;20140131;第20卷(第1期);第120-123页 * |
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Effective date of registration: 20200929 Address after: Unit 1101, unit 1, No.30, Yishui Huating community, suixian central street, Zhengzhou City, Henan Province Patentee after: Feng Dongpo Address before: 450001 Henan province Zhengzhou City navigation road and Qinling Mountains Road intersection, No. 3 building 901 macro space model Patentee before: Feng Jinchu Patentee before: Lu Shujun |
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Effective date of registration: 20210818 Address after: 450000 Building 2, yard 6, Jinghu village, South University Road, Zhengzhou City, Henan Province Patentee after: Feng Jinchu Patentee after: Lu Shujun Address before: 476900 1101, unit 1, No. 30, yishuihuating community, central street, Sui County, Zhengzhou City, Henan Province Patentee before: Feng Dongpo |