CN100411663C - Anticancer compound Chinese medicine powder and its preparing method - Google Patents
Anticancer compound Chinese medicine powder and its preparing method Download PDFInfo
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Abstract
The present invention relates to compound traditional Chinese medicine powder for preventing cancer, which is mainly prepared from the following raw materials by weight: 15 to 35 shares of oldenlandia, 5 to 25 shares of rhizoma paridis, 5 to 20 shares of chiese eaglewood wood, 5 to 15 shares of notoginseng, 5 to 20 shares of princes-feather fruit, 5 to 15 shares of processed pinellia tuber, 5 to 25 shares of american ginseng, 5 to 20 shares of bupleurum root and 5 to 15 shares of rhubarb. In a preparing method, the raw materials are mixed and pulverized according to proportion; after water is added to the raw materials, the raw materials are extracted for 2 to 3 times; after 95% ethanol whose weight is 5 to 10 times more than that of the raw materials is added to the raw materials, the raw materials are extracted for 2 to 3 times; the extracting solution is merged, and solution to be used is prepared after the merged extracting solution is concentrated, decomposed by ethanol, and stirred; then 10 mg/ml sodium tripolyphosphate solution is prepared, and after being stirred at high speed, the sodium tripolyphosphate solution is dropped into the solution to be used; finally, the mixed solution is volatilized by a ventilating cabinet to no ethanol smell, and is dried in vacuum to form the powder to be packed in a bottle. The compound traditional Chinese medicine powder for preventing cancer of the present invention has favorable therapeutic efficacy for various tumor diseases such as lung cancer, and has the advantages of no toxic or side effect and simple preparing technology.
Description
Technical field
The present invention relates to medicine field, relating in particular to a kind of is to be the herbal mixture Propylenediamine Tetraacetylimide and preparation method thereof of the various tumors of feature being used for the treatment of of feedstock production with pulmonary carcinoma with the natural plant.
Background technology
Cancer is the main killer who threatens the human life, its M ﹠ M has tangible ascendant trend in recent years, World Health Organization's prediction 21st century cancer is that human " first killer " becomes a reality, according to statistics, because of the number of cancer stricken death has accounted for position first of the current three big causes of the death (malignant tumor, cardiovascular disease, cerebrovascular disease), seize more than 600 ten thousand people's life every year, and nearly 1,000 ten thousand people are placed dead edge, the cancer number was suffered from up to 7,000 ten thousand people in the whole world in 2002.China is because vast in territory, and various nationalities' life style and customs varies, therefore the phenomenon that has developing country and developed country cancer occurred frequently concurrently and deposit.
Clinical practice operation, radiation and chemotherapy are treated, saved part patient's life, but toxic and side effects is also very serious, it has also killed a large amount of normal cells in kill cancer cell, except each internal organs of health are caused damage, also can suppress body's immunological function, cause the immunologic function of the former low cancer patient of immunologic function lower; At present, the cancer patient who dies from treatment every year accounts for 51%.And pulmonary carcinoma is that human health and life are threatened maximum malignant tumor, and its sickness rate has risen to the first place of malignant tumor in recent years, and sickness rate and case fatality rate all occupy the first place of China's male tumor.Although novel chemotherapeutics and treatment means emerge in an endless stream, whole curative effect is dissatisfied, and survival rate still had only about 15% in 5 years.So, explore to strengthen chemotherapy, radiotherapy curative effect, alleviate its side reaction, can improve the medicine of host immune function simultaneously again, be the emphasis of present tumor therapeutics research.Chinese scholars has begun to change to the idea of oncotherapy effect assessment in recent years, pursued the foci disappearance rate merely in the past, the Stabilization of ignoring focus, present then affirmed the value of survival that the band cancer is prolonged life behind the patient treatment, paid attention to improving patient's life quality, long term survival rate adopts Chinese medicine can make patient's " existence of band tumor " or " with tumor cell peaceful coexistence " for many years.Along with medical model by changing to sociology biology, patient's quality of life more and more comes into one's own.Chinese medicine medicine for preventing is compared with chemotherapeutics, and one of its advantage is that untoward reaction is little, and is under Chinese medical theory instructs, and can improve patient's body constitution situation comprehensively.To the advanced lung cancer patient, Chinese medicine can improve clinical symptoms, alleviates the patient suffering, improves patient's deficient state, appetite stimulator and improve patient's life quality greatly.So, treat a kind of like this systemic disease, excise focus or local radiotherapy separately and be difficult to thoroughly cure, and tackle focus separately, very easily cause transfer, diffusion and recurrence.Traditional chemotherapy, radiotherapy can only produce the disastrous effect of " eliminating evil just also decline ".The used element of radiotherapy and chemotherapy was carcinogen originally, and it is the makeshift of doing something against one's will that medical circle is used for the clinical cancer of controlling.Yet treatment for cancer generally adopts comprehensive therapy, and Chinese medicine is anticancer to be one of effective means of combined therapy of tumour.
Summary of the invention
Technical problem to be solved by this invention is: based on understanding and the Therapeutic Principle of motherland's medical science to treating various tumor disease mechanism, with the Basic Theories of Chinese Medicine is guidance, achieve with reference to modern pharmacology, provide the concrete disease of a kind of basis to use dialectical opinion to control and compatibility of medicines in a prescription principle is formed, running through traditional Chinese medical science thought characteristic, being used for the treatment of with pulmonary carcinoma is the various tumor diseases of feature and the preparation method of herbal mixture Propylenediamine Tetraacetylimide and slow release thereof, controlled release preparation fast and effectively.
The present invention solves its technical problem and adopts following technical scheme:
The herbal mixture Propylenediamine Tetraacetylimide that is used for the treatment of with pulmonary carcinoma the various tumor diseases that are feature provided by the invention is mainly made by the raw material of following weight portion: 5～15 parts of 15～35 parts of Herba Hedyotidis Diffusaes, 5～25 parts of Rhizoma Paridiss, 5～20 parts of Lignum Aquilariae Resinatum, 5～15 parts of Radix Notoginseng, 5～20 parts of Fructus Polygoni Orientaliss, 5～15 parts of Rhizoma Pinelliae Preparatum, 5～25 parts of Radix Panacis Quinquefoliis, 5～20 parts of Radix Bupleuri and Radix Et Rhizoma Rhei.
The above-mentioned treatment of preparation provided by the invention is the various tumor diseases of feature and the method for herbal mixture Propylenediamine Tetraacetylimide fast and effectively with pulmonary carcinoma, and it may further comprise the steps:
Raw material is mixed pulverizing according to the above ratio, the water extraction 2～3 times that adds 5～10 times of weight, each 1.5～2 hours, add 95% ethanol extraction 2～3 times of 5～10 times of weight again, each 1.5～2 hours, merge extractive liquid,, be concentrated into fluid extract, add 1 of 100～300 times of weight of fluid extract again, after the ethylene glycol of 2-propylene glycol and 100～200 times of weight of fluid extract fully dissolves, the chitosan magnetic force that adds 10～20 times of weight of fluid extract stirs 20～30min, makes stand-by solution; Dispose the sodium tripolyphosphate solution of 10mg/ml then, after the high-speed stirred of 10000r/min, drip in the stand-by solution; At last, evaporating in fume hood does not have the alcohol flavor, and vacuum drying utilizes the preparation method bottling of known powder aerosol to powder, can be made into promptly that can to treat with pulmonary carcinoma be the various tumor diseases of feature and herbal mixture Propylenediamine Tetraacetylimide fast and effectively.
The present invention compared with prior art has following main useful result:
One, can treat with pulmonary carcinoma is the various tumor diseases of feature, is natural drug, forms by the tcm theory prescription.
Its two, this efficacy of drugs: heat-clearing and toxic substances removing, promoting flow of QI and blood, dissipating phlegm and resolving masses, reducing swelling and alleviating pain, benefiting QI and nourishing blood.To being that the various tumor diseases of feature have excellent curative with pulmonary carcinoma, have no side effect.
Its three, this medicine cancerous protuberance that can dissipate, thus prolong patient's life, also may command shifts, alleviates cancer pain, improves syndrome, improves life quality, prolongs band cancer life cycle.
Its four, this medicine can utilize modern preparation technique to make slow release, controlled release preparation.
Description of drawings
Accompanying drawing is the releasing curve diagram of astragaloside in embodiment 6 nano-drug preparations.
The specific embodiment
Herbal mixture Propylenediamine Tetraacetylimide provided by the invention is according to compatibility foundation and test effect, and its combination formula has following several:
Embodiment 1. is mainly made by the raw material of following weight portion:
15～35 parts of Herba Hedyotidis Diffusaes, 5～25 parts of Rhizoma Paridiss, 5～20 parts of Lignum Aquilariae Resinatum, 5～15 parts of Radix Notoginseng, 5～20 parts of Fructus Polygoni Orientaliss, 5～15 parts of Rhizoma Pinelliae Preparatum, 5～25 parts of Radix Panacis Quinquefoliis, 5～20 parts of Radix Bupleuri, 5～15 parts of Radix Et Rhizoma Rhei.
Embodiment 2. also has the raw material of following weight parts on the basis of embodiment 1: 0～5 part of Herba Portulacae Grandiflorae, 0～10 part of Cortex Magnoliae Officinalis, 0～15 part of Fructus Aurantii, 0～15 part of Rhizoma Corydalis, 0～5 part of Rhizoma Pinelliae Preparatum, 0～5 part of Radix Angelicae Sinensis, 0～10 part in the Radix Rehmanniae, 0～5 part of the Radix Paeoniae Alba, 0～10 part of Carapax Trionycis.
Embodiment 3. herbal mixture Propylenediamine Tetraacetylimides can be made by the raw material of following weight portion:
25 parts of Herba Hedyotidis Diffusaes, 15 parts of Rhizoma Paridiss, 15 parts of Lignum Aquilariae Resinatum, 10 parts of Radix Notoginseng, 15 parts of Fructus Polygoni Orientaliss, 5 parts of Rhizoma Pinelliae Preparatum, 10 parts of Radix Panacis Quinquefoliis, 10 parts of Radix Bupleuri, 10 parts of Radix Et Rhizoma Rhei, 5 parts of Herba Portulacae Grandifloraes, 8 parts of Cortex Magnoliae Officinalis, 12 parts of Fructus Aurantiis, 10 parts of Rhizoma Corydalis, 5 parts of Rhizoma Pinelliae Preparatum, 5 parts of Radix Angelicae Sinensis, 7 parts in the Radix Rehmanniae, 5 parts of the Radix Paeoniae Albas, 10 parts of Carapax Trionycis.
The compatibility of above herbal mixture Propylenediamine Tetraacetylimide is according to as follows:
Propylenediamine Tetraacetylimide is made up of Herba Hedyotidis Diffusae, Rhizoma Paridis, Lignum Aquilariae Resinatum, Radix Notoginseng, Fructus Polygoni Orientalis, Rhizoma Pinelliae Preparatum, Radix Panacis Quinquefolii, Radix Bupleuri, Radix Et Rhizoma Rhei nine flavor Chinese medicines.Effect is a heat-clearing and toxic substances removing, promoting flow of QI and blood, resolving phlegm and softening hard masses, reducing swelling and alleviating pain, benefiting QI and nourishing blood.Mainly curing cancer of lung, symptoms including cough, out of breath, uncomfortable in chest, heating, hemoptysis, chest pain, even cough vomiting bloody pus etc., also can be used for cancerous protuberances such as hepatocarcinoma.Motherland's medical science thinks that healthy energy is hindered earlier, evil drug-pedlar's lung, so that lung qi smoulders, mistake department falls in a surname, and disorder of QI movement, stagnation of blood stasis, venation obstruction etc. are the main pathology that forms pulmonary carcinoma, cure the disease and must ask it, control the cancer detoxifcation for earlier.Herba Hedyotidis Diffusae bitter cold in the side has stronger antipyretic and antidote functions, to control diseases such as pyretic toxicity.Modern study confirms that it is to the acute lymphoblastic type, and the tumor cell of monocyte type and chronic granulocyte type has stronger inhibitory action.All there is antitumor action at effective ingredient such as oleanolic acid, triterpenic acid, Coumarins and polysaccharide and position in the Herba Hedyotidis Diffusae, triterpenes antitumous effect optimum wherein, and sterols then is an invalid components.The pharmacology proves: Herba Hedyotidis Diffusae has inhibitory or killing effect to white mice ascites hepatocarcinoma.The Rhizoma Paridis hardship can be fallen and be let out, but cold heat clearing away, so heat-clearing and toxic substances removing is arranged, the merit of reducing swelling and alleviating pain; It all has obvious inhibitory action to murine sarcoma-180, sarcoma-37, and suppression ratio 40%-50% is 30%-40% to the rat liver cancer suppression ratio.Rhizoma Paridis has inhibitory action to murine sarcoma S-180 in addition.Above Herba Hedyotidis Diffusae and Rhizoma Paridis all have the effect of heat-clearing and toxic substances removing, share then and bring out the best in each other, and the effect high-tensile strength is grand, is monarch drug altogether.
Lignum Aquilariae Resinatum fragrance is walked to scurry, and acrid in the mouth is and capable diffusing, and circulation of qi promoting ends bitterly.The Radix Notoginseng bitter in the mouth is warm in nature, blood circulation promoting and blood stasis dispelling, and the merit of reducing swelling and alleviating pain is distinguished; The pharmacology proves: isolating the polysaccharide component that contains Ara, Gal, Glc etc. from the water extract of Radix Notoginseng has anti-tumor activity, and murine sarcoma-180 is had inhibitory action, can prolong the transplantation tumor animal life-span.Radix Notoginseng contains ginsenoside, arasaponin etc., existing experiment confirm Radix Notoginseng energy inducing cancer cell differentiation, arasaponin Rg1 energy anticancer DNA and RNA are synthetic, and this inhibitory action may slow down with causing cell proliferation, interference cell gene expression, the energy raise immunity; Observed influence simultaneously to phytohaemagglutinin (PHA) inducing mouse lymphocyte transformation effect.The Fructus Polygoni Orientalis salty in the mouth, the function softening the hard mass is used to control the emblem vacation and gathers, and in recent years, commonly used its treated various tumors clinically, and to ehrlich carcinoma, S-180 has above three flavor medical material (Lignum Aquilariae Resinatum, Radix Notoginseng, the Fructus Polygoni Orientalis) promoting flow of QI and blood of inhibitory action, is ministerial drug altogether.
Rhizoma Pinelliae Preparatum is hot warm and dry, and drying dampness to eliminate phlegm is arranged, and suffering is opened the merit of eliminating stagnation.Radix Panacis Quinquefolii is sweet cold, tonifying the lung gas, and asthenic fire falls in lung benefiting the moon, clearing away lung-heat; This two flavor (Rhizoma Pinelliae Preparata, Radix Panacis Quinquefolii) share then strengthening vital QI to eliminate pathogenic factors, is adjuvant drug altogether.Radix Bupleuri lightly floats to rise and looses, and medicine-carried is up, and through sick institute also has the soothing the liver merit of heat clearing away.The Radix Et Rhizoma Rhei bitter cold is fallen and is rushed down, and it is descending to draw in the heart pyretic toxicity blood stasis etc., is gone out by stool, gives evil in outlet.This two medicine is all adjuvant.
All medicines (nine flavor Chinese medicine) share, it is rigorous to fill a prescription, and heresy is just taken into account, and plays the heat-clearing and toxic substances removing promoting flow of QI and blood altogether, dissipating phlegm and resolving masses, reducing swelling and alleviating pain, the merit of benefiting QI and nourishing blood is used for cancers such as pulmonary carcinoma, not only can obviously improve symptom, and the cancerous protuberance that can dissipate, thereby prolong patient's life, also may command shifts, alleviates cancer pain, improves syndrome, improves life quality, prolongs band cancer life cycle.
The invention provides the preparation method of herbal mixture Propylenediamine Tetraacetylimide, it may further comprise the steps: raw material is mixed pulverizing according to the above ratio, the water extraction 2～3 times that adds 5～10 times of weight, each 1.5～2 hours, 95% ethanol extraction 2～3 times that adds 5～10 times of weight again, each 1.5～2 hours, merge extractive liquid,, be concentrated into fluid extract, add 1 of 100～300 times of weight of fluid extract again, after the ethylene glycol of 2-propylene glycol and 100～200 times of weight of fluid extract fully dissolved, the chitosan magnetic force that adds 10～20 times of weight of fluid extract stirred 20～30min, makes stand-by solution; Dispose the sodium tripolyphosphate solution of 10mg/ml then, after the high-speed stirred of 10000r/min, drip in the stand-by solution; At last, evaporating in fume hood does not have the alcohol flavor, and vacuum drying utilizes the preparation method bottling of known powder aerosol to powder, can be made into promptly that can to treat with pulmonary carcinoma be the various tumor diseases of feature and herbal mixture Propylenediamine Tetraacetylimide fast and effectively.
Herbal mixture Propylenediamine Tetraacetylimide of the present invention, its dosage form can be slow release or controlled release preparation and the aerosol made thereof.
Below in conjunction with three embodiment preparation method of the present invention is described further.
Embodiment 4: Nano medication microsphere 1
Take by weighing each component (kg) by following recipe ratio: Herba Hedyotidis Diffusae 35, Rhizoma Paridis 5, Lignum Aquilariae Resinatum 20, Radix Notoginseng 5, Fructus Polygoni Orientalis 20, Rhizoma Pinelliae Preparatum 5, Radix Panacis Quinquefolii 25, Radix Bupleuri 5, Radix Et Rhizoma Rhei 15.
Preparation method may further comprise the steps: be mixed in proportion, the water extraction 2 times that adds 5 times of weight, each 1.5 hours, add 95% ethanol extraction 2 times of 5 times of weight again, each 1.5 hours, merge extractive liquid,, be concentrated into fluid extract, add 1 of 100 times of weight of fluid extract again, after the ethylene glycol of 2-propylene glycol and 100 times of weight of fluid extract fully dissolves, the chitosan magnetic force that adds 10 times of weight of fluid extract stirs 20min, makes stand-by solution; Dispose the sodium tripolyphosphate solution of 10mg/ml then, after the high-speed stirred of 10000r/min, drip in the stand-by solution; At last, evaporating in fume hood does not have the alcohol flavor, and vacuum drying utilizes the preparation method bottling of known powder aerosol to powder, gets final product.
Embodiment 5: Nano medication microsphere 2
Take by weighing each component (kg) by following recipe ratio: Herba Hedyotidis Diffusae 15, Rhizoma Paridis 25, Lignum Aquilariae Resinatum 5, Radix Notoginseng 15, Fructus Polygoni Orientalis 5, Rhizoma Pinelliae Preparatum 15, Radix Panacis Quinquefolii 5, Radix Bupleuri 20, Radix Et Rhizoma Rhei 5, Herba Portulacae Grandiflorae 5, Cortex Magnoliae Officinalis 10, Fructus Aurantii 15, Rhizoma Corydalis 15, Rhizoma Pinelliae Preparatum 5, Radix Angelicae Sinensis 5, the Radix Rehmanniae 10, the Radix Paeoniae Alba 5, Carapax Trionycis 10.
Preparation method may further comprise the steps: be mixed in proportion, the water extraction 3 times that adds 10 times of weight, each 2 hours, add 95% ethanol extraction 3 times of 10 times of weight again, each 2 hours, merge extractive liquid,, be concentrated into fluid extract, add 1 of 300 times of weight of fluid extract again, after the ethylene glycol of 2-propylene glycol and 200 times of weight of fluid extract fully dissolves, the chitosan magnetic force that adds 20 times of weight of fluid extract stirs 30min, makes stand-by solution; Dispose the sodium tripolyphosphate solution of 10mg/ml then, after the high-speed stirred of 10000r/min, drip in the stand-by solution; At last, evaporating in fume hood does not have the alcohol flavor, and vacuum drying utilizes the preparation method bottling of known powder aerosol to powder, gets final product.
Embodiment 6: Nano medication microsphere 3
Take by weighing each component (kg) by following recipe ratio: 25 parts of Herba Hedyotidis Diffusaes, 15 parts of Rhizoma Paridiss, 15 parts of Lignum Aquilariae Resinatum, 10 parts of Radix Notoginseng, 15 parts of Fructus Polygoni Orientaliss, 5 parts of Rhizoma Pinelliae Preparatum, 10 parts of Radix Panacis Quinquefoliis, 10 parts of Radix Bupleuri, 10 parts of Radix Et Rhizoma Rhei, 5 parts of Herba Portulacae Grandifloraes, 8 parts of Cortex Magnoliae Officinalis, 12 parts of Fructus Aurantiis, 10 parts of Rhizoma Corydalis, 5 parts of Rhizoma Pinelliae Preparatum, 5 parts of Radix Angelicae Sinensis, 7 parts in the Radix Rehmanniae, 5 parts of the Radix Paeoniae Albas, 10 parts of Carapax Trionycis.
Preparation method may further comprise the steps: be mixed in proportion, the water extraction 3 times that adds 8 times of weight, each 1.5 hours, add 95% ethanol extraction 3 times of 8 times of weight again, each 1.5 hours, merge extractive liquid,, be concentrated into fluid extract, add 1 of 250 times of weight of fluid extract again, after the ethylene glycol of 2-propylene glycol and 150 times of weight of fluid extract fully dissolves, the chitosan magnetic force that adds 18 times of weight of fluid extract stirs 30min, makes stand-by solution; Dispose the sodium tripolyphosphate solution of 10mg/ml then, after the high-speed stirred of 10000r/min, drip in the stand-by solution; At last, evaporating in fume hood does not have the alcohol flavor, and vacuum drying utilizes the preparation method bottling of known powder aerosol to powder, gets final product.
This compound anti-cancer powder preparation effective ingredient ginsenoside Rg1's (Ginsenoside Rg1) assay is pressed the standards of pharmacopoeia method and is measured.
Ginsenoside Rg1's assay instrument and condition determination: Tianjin, island LC-10AT high performance liquid chromatograph, SPD-10Avp UV, visible light detector, the U-3400 of Hitachi type spectrophotometer.Chromatographic condition: Tianjin, island VP-ODS chromatographic column (150L * 4.6), mobile phase is 1,2-dichloroethanes-n-butyl alcohol-methanol-water (30: 40: 15: 25), 40 ℃ of column temperatures, flow velocity 1ml/min, the detection wavelength is 204.4nm.
The mensuration of sample release performance: get this compound anti-cancer Nano medication microsphere that looses, measure each ginsenoside Rg1's content in sample constantly, draw release profiles (seeing accompanying drawing) by official method.
Nano microsphere has slow-release function, has reduced number of times and consumption that the patient takes medicine, greatly reduces patient's misery and the difficulty of taking medicine, and this Nano medication microsphere release rate after 36 hours does not reach 100% yet, so only need take medicine every day and get final product for 1 time.
Nano microsphere self by the preparation of chitosan and sodium tripolyphosphate has antibacterial action, has increased compound anti-cancer and has loose to being the therapeutic effect of the various tumor diseases of feature with pulmonary carcinoma.
Prove that Propylenediamine Tetraacetylimide of the present invention and slow release thereof, controlled release preparation can effectively suppress the growth of various tumor cells through pharmacological testing: the Propylenediamine Tetraacetylimide fluid extract of 50 μ g/ml is 62.36%, is 60.42% to the suppression ratio of stomach cancer cell HGC the suppression ratio of lung cell A549; The Propylenediamine Tetraacetylimide Nano medication microsphere of 50 μ g/ml is 74.18%, is 71.33% to the suppression ratio of stomach cancer cell HGC the suppression ratio of lung cell A549, and clinical to pulmonary carcinoma be total remission rate of various tumor diseases of feature up to 83%, have higher scientific and creative.Above data declaration Propylenediamine Tetraacetylimide treatment is possible of the various tumor diseases of feature with pulmonary carcinoma.
The toxicity test of herbal mixture Propylenediamine Tetraacetylimide of the present invention:
Press the 600g/kg dosed administration through the Kunming mouse gastric infusion, observed seven days, do not see the overt toxicity reaction, no animal dead is not measured median lethal dose(LD 50), and its maximum dosage-feeding is 600g/kg.
One of we think that Propylenediamine Tetraacetylimide is that treatment at present is that the various tumor disease effects of feature are better with pulmonary carcinoma, and the medicine that has no side effect.
Claims (6)
1. herbal mixture Propylenediamine Tetraacetylimide is characterized in that mainly being made by the raw material of following weight portion: 5～15 parts of 15～35 parts of Herba Hedyotidis Diffusaes, 5～25 parts of Rhizoma Paridiss, 5～20 parts of Lignum Aquilariae Resinatum, 5～15 parts of Radix Notoginseng, 5～20 parts of Fructus Polygoni Orientaliss, 5～15 parts of Rhizoma Pinelliae Preparatum, 5～25 parts of Radix Panacis Quinquefoliis, 5～20 parts of Radix Bupleuri and Radix Et Rhizoma Rhei.
2. herbal mixture Propylenediamine Tetraacetylimide according to claim 1 is characterized in that being made by the raw material of following weight portion: 10 parts of 25 parts of Herba Hedyotidis Diffusaes, 15 parts of Rhizoma Paridiss, 15 parts of Lignum Aquilariae Resinatum, 10 parts of Radix Notoginseng, 15 parts of Fructus Polygoni Orientaliss, 5 parts of Rhizoma Pinelliae Preparatum, 10 parts of Radix Panacis Quinquefoliis, 10 parts of Radix Bupleuri, 10 parts of Radix Et Rhizoma Rhei, 5 parts of Herba Portulacae Grandifloraes, 8 parts of Cortex Magnoliae Officinalis, 12 parts of Fructus Aurantiis, 10 parts of Rhizoma Corydalis, 5 parts of Rhizoma Pinelliae Preparatum, 5 parts of Radix Angelicae Sinensis, 7 parts in the Radix Rehmanniae, 5 parts of the Radix Paeoniae Albas and Carapax Trionycis.
3. the preparation method of herbal mixture Propylenediamine Tetraacetylimide, it is characterized in that may further comprise the steps: raw material is mixed in proportion pulverizing, the water extraction 2～3 times that adds 5～10 times of weight, each 1.5～2 hours, 95% ethanol extraction 2～3 times that adds 5～10 times of weight again, each 1.5～2 hours, merge extractive liquid,, be concentrated into fluid extract, add 1 of 100～300 times of weight of fluid extract again, after the ethylene glycol of 2-propylene glycol and 100～200 times of weight of fluid extract fully dissolved, the chitosan magnetic force that adds 10～20 times of weight of fluid extract stirred 20～30min, makes stand-by solution; Dispose the sodium tripolyphosphate solution of 10mg/ml then, after the high-speed stirred of 10000r/min, drip in the stand-by solution; At last, evaporating in fume hood does not have the alcohol flavor, and vacuum drying utilizes the preparation method bottling of known powder aerosol to powder, and promptly can be made into treatment pulmonary carcinoma is the herbal mixture Propylenediamine Tetraacetylimide medicine of the various tumor diseases of feature,
The combination formula of said medicine mainly contains the raw material of following weight portion: 5～15 parts of 15～35 parts of Herba Hedyotidis Diffusaes, 5～25 parts of Rhizoma Paridiss, 5～20 parts of Lignum Aquilariae Resinatum, 5～15 parts of Radix Notoginseng, 5～20 parts of Fructus Polygoni Orientaliss, 5～15 parts of Rhizoma Pinelliae Preparatum, 5～25 parts of Radix Panacis Quinquefoliis, 5～20 parts of Radix Bupleuri and Radix Et Rhizoma Rhei.
4. the preparation method of herbal mixture Propylenediamine Tetraacetylimide according to claim 3 is characterized in that being made by the raw material of following weight portion: 10 parts of 25 parts of Herba Hedyotidis Diffusaes, 15 parts of Rhizoma Paridiss, 15 parts of Lignum Aquilariae Resinatum, 10 parts of Radix Notoginseng, 15 parts of Fructus Polygoni Orientaliss, 5 parts of Rhizoma Pinelliae Preparatum, 10 parts of Radix Panacis Quinquefoliis, 10 parts of Radix Bupleuri, 10 parts of Radix Et Rhizoma Rhei, 5 parts of Herba Portulacae Grandifloraes, 8 parts of Cortex Magnoliae Officinalis, 12 parts of Fructus Aurantiis, 10 parts of Rhizoma Corydalis, 5 parts of Rhizoma Pinelliae Preparatum, 5 parts of Radix Angelicae Sinensis, 7 parts in the Radix Rehmanniae, 5 parts of the Radix Paeoniae Albas and Carapax Trionycis.
5. the preparation method of herbal mixture Propylenediamine Tetraacetylimide according to claim 3, it is characterized in that: the water extraction 3 times that adds 8 times of weight, each 1.5 hours, add 95% ethanol extraction 3 times of 8 times of weight again, each 1.5 hours, merge extractive liquid,, be concentrated into fluid extract, add 1 of 250 times of weight of fluid extract again, after the ethylene glycol of 2-propylene glycol and 150 times of weight of fluid extract fully dissolves, the chitosan magnetic force that adds 18 times of weight of fluid extract stirs 30min, makes stand-by solution; Dispose the sodium tripolyphosphate solution of 10mg/ml then, after the high-speed stirred of 10000r/min, drip in the stand-by solution; At last, evaporating in fume hood does not have the alcohol flavor, and vacuum drying utilizes the preparation method bottling of known powder aerosol to get final product to powder.
6. the preparation method of herbal mixture Propylenediamine Tetraacetylimide according to claim 3 is characterized in that: the dosage form of herbal mixture Propylenediamine Tetraacetylimide is slow release or controlled release preparation and the aerosol made thereof.
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| CN1170556C (en) * | 2000-06-12 | 2004-10-13 | 吴建华 | Chinese medicine for treating neoplasm |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1170556C (en) * | 2000-06-12 | 2004-10-13 | 吴建华 | Chinese medicine for treating neoplasm |
Non-Patent Citations (2)
| Title |
|---|
| 抗肺癌复方中药-抗癌散. 楼一层，刘莹，谢周涛，刘焱文.湖北中医杂志，第27卷第10期. 2005 |
| 抗肺癌复方中药-抗癌散. 楼一层，刘莹，谢周涛，刘焱文.湖北中医杂志，第27卷第10期. 2005 * |
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