CN107050175A - It is a kind of to treat Chinese medicine preparation of vasculitis and preparation method thereof - Google Patents
It is a kind of to treat Chinese medicine preparation of vasculitis and preparation method thereof Download PDFInfo
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- CN107050175A CN107050175A CN201710173522.5A CN201710173522A CN107050175A CN 107050175 A CN107050175 A CN 107050175A CN 201710173522 A CN201710173522 A CN 201710173522A CN 107050175 A CN107050175 A CN 107050175A
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Abstract
The present invention relates to a kind of Chinese medicine preparation for treating vasculitis and preparation method thereof, the Chinese medicine preparation includes the bulk drug of following weight proportion：80~120 parts of Radix Angelicae Sinensis, 80~120 parts of Ligusticum wallichii, 80~120 parts of the radix paeoniae rubrathe, 80~120 parts of the dried rhizome of rehmannia, 130~170 parts of ilex pubescens, 80~120 parts of safflower, 80~120 parts of earthworm, 80~120 parts of ground beetle, 80~120 parts of radix scrophulariae, 80~120 parts of honeysuckle, 80~120 parts of the red sage root, 20~40 parts of monkshood, 80~120 parts of radix glycyrrhizae, 80~120 parts of the root of bidentate achyranthes, 80~120 parts of ramulus mori；Chinese medicine preparation of the present invention has clearing heat and detoxicating, blood circulation promoting nourishes blood, blood-activating analgetic, the effect tonified the liver and kidney.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation for treating vasculitis and preparation method thereof, belong to technical field of Chinese medicine.
Background technology
Vasculitis be also known as Buerger's disease be a kind of rare chronic recurrent in, the section of parteriole and vein
Property diseases associated with inflammation, using lower limb to be common.Clinical manifestation is suffering limb ischemic, pain, Charcot's syndrome, pulsation of foot dorsal artery decrease
Or disappear and migrans Superficial phlebitis, severe patient has acra ulcer and necrosis.The disease be apt to occur in 20~40 years old between middle green grass or young crops
Year male, is a kind of disability rate very high systemic disease, and severe patient can add up important organ and blood vessel.It is used as common limbs
Arterial occlusive disease, is 8/,100,000 in the incidence of disease of China.The disease using chronic section and cyclical recurrent as its feature,
The state of an illness is complicated, and the course of disease is long, it is difficult to cure, disability rate is higher.Mesh at present, is used more clinical treatment Buerger's disease
Fat, platelet aggregation-against and operative treatment, but the easy recurrent exerbation of the state of an illness are adjusted, curative effect is undesirable, and few patients even the state of an illness occur
Aggravate, the extensive gangrene of lower limb such as occur and need the poor prognosis of amputation, have a strong impact on the quality of life of patient.Thus seek height
Effect, the treatment method of safety are particularly important to Buerger's disease.
This disease category traditional Chinese medicine " gangrene of finger or toe ", the category such as " vessle-Bi symptom-complex " or " evil arteries and veins ".This cause of disease by " cold ", " wet ", " stasis of blood " heresy
Caused by invasion and attack, so that zang-fu disharmony, stagnation of QI-blood, train of thought is obstructed to be formed.Inside and outside two because of, internal cause or because of caused by liver and kidney deficiency, temper not
Strong, or excess of sexual intercourse,indulgence in sexual activities, it is withered that gas exhausts essence, and temperature transports powerless, visceral dysfunction, and blood vessels are not smooth etc.；External cause can be to experience fever and chills damp evil,
Or suck cigarette poison, dye etc. outside tinea worm.Again《Yizong Jinjian》Say：" carbuncle and cellulitis being originally caused by fire toxin, channels and collaterals barrier qi and blood coagulates ",《Gold is deficient will
Slightly》Cloud：" stagnate blood vessels for the not sick blood of sick water person, main spasm of trembling with fear, and causes sluggishness of blood circulation obstructed and the stasis of blood ", that is, refer to the wet cohesion of water, heat
Enter ying blood, heat mixing with blood, blood lose moisten it is foster, it is popular not smooth and cause blood stasis.
Traditional Chinese medicine and pharmacy has the understanding of uniqueness, and the rich experience accumulated in terms of this disease is treated, with multi-level, many targets
The advantage of point.
The content of the invention
To overcome the deficiencies in the prior art, the invention provides a kind of Chinese medicine preparation for treating vasculitis and its preparation side
Method, the Chinese medicine preparation has the advantages that evident in efficacy, with low cost, toxic side effect is smaller.
This disease is more, and because of feelings will internal injury, temper is not good for, kidney deficiency and liver, and cold-dampness is attacked in addition, and stagnate train of thought, inaccessible obstructed, blood
Fortune is not smooth, and yang-energy does not reach, and loses caused by Wen Tongru is supported.It is multiple because of Cold-dampness, qi and blood stagnation, not general rule pain；The strongly fragrant longization heat of cold-dampness,
Accumulate malicious contamination, symptoms include heat toxin time.The traditional Chinese medical science thinks, blood stored in the liver, cage bar, kidney storing essence, main bone；Kidney deficiency and liver, then muscles and bones damage, so
Originally there are injuring both tendon and bone, qi-blood deficiency pathological characteristic the phase after being ill.
Prescription of the present invention is monarch drug in a prescription altogether from ilex pubescens and honeysuckle, can be clearing heat and detoxicating, cool blood；Being equipped with Radix Angelicae Sinensis can enrich blood work
Blood, Ligusticum wallichii energy promoting qi circulation and relieving pain, the radix paeoniae rubrathe, clearing heat and cooling blood, the dried rhizome of rehmannia, cool blood, yin-nourishing is promoted the production of body fluid, and safflower is promoting blood circulation and removing blood stasis, radix scrophulariae, and cool blood is grown
The moon, the red sage root, stasis-dispelling and pain-killing, monkshood, yang-tonic tongmai, above-mentioned each medicine is altogether ministerial drug, then is aided with earthworm, and ground bettle is the medicine of adjuvant two
The work(of the broken silt of the enhancing that matches, four medicine phases are matched somebody with somebody can promoting blood circulation and stopping pain；Again the compatibility root of bidentate achyranthes, ramulus mori, can priming channel tropism it is descending, in enhancing side work
Blood stagnation resolvation, the work(tonified the liver and kidney.Above-mentioned all medicine phases are matched somebody with somebody, and tonification and purgation in combination, can play a part for the treatment of both principal and secondary aspect of disease.And qi and blood is led to
Freely, peripheral blood normal operation, then all disease disappearance or improvement.Clearing heat and detoxicating, blood circulation promoting nourishes blood is played altogether, and blood-activating analgetic tonifies the liver and kidney
Work(.
The Chinese medicine preparation of the present invention, it is made up of the bulk drug of following weight proportion：80~120 parts of Radix Angelicae Sinensis, Ligusticum wallichii 80
~120 parts, 80~120 parts of the radix paeoniae rubrathe, 80~120 parts of the dried rhizome of rehmannia, 130~170 parts of ilex pubescens, 80~120 parts of safflower, earthworm 80~
120 parts, 80~120 parts of ground beetle, 80~120 parts of radix scrophulariae, 80~120 parts of honeysuckle, 80~120 parts of the red sage root, monkshood 20~40
Part, 80~120 parts of radix glycyrrhizae, 80~120 parts of the root of bidentate achyranthes, 80~120 parts of ramulus mori.
It is preferred that, Chinese medicine preparation of the invention, it is made up of the bulk drug of following weight proportion：90~110 parts of Radix Angelicae Sinensis,
90~110 parts of Ligusticum wallichii, 90~110 parts of the radix paeoniae rubrathe, 90~110 parts of the dried rhizome of rehmannia, 140~160 parts of ilex pubescens, 90~110 parts of safflower, earthworm
90~110 parts, 90~110 parts of ground beetle, 90~110 parts of radix scrophulariae, 90~110 parts of honeysuckle, 90~110 parts of the red sage root, monkshood 25
~350 parts, 90~110 parts of radix glycyrrhizae, 90~110 parts of the root of bidentate achyranthes, 90~110 parts of ramulus mori.
It is preferred that, Chinese medicine preparation of the invention, it is made up of the bulk drug of following weight proportion：It is by following weight
The bulk drug of part proportioning：100 parts of Radix Angelicae Sinensis, 100 parts of Ligusticum wallichii, 100 parts of the radix paeoniae rubrathe, 100 parts of the dried rhizome of rehmannia, 150 parts of ilex pubescens, 100 parts of safflower,
100 parts of earthworm, 100 parts of ground beetle, 100 parts of radix scrophulariae, 100 parts of honeysuckle, 100 parts of the red sage root, 30 parts of monkshood, 100 parts of radix glycyrrhizae, the root of bidentate achyranthes
100 parts, 100 parts of ramulus mori.
It is preferred that, Chinese medicine preparation of the invention, it is made up of the bulk drug of following weight proportion：It is by following weight
The bulk drug of part proportioning：110 parts of Radix Angelicae Sinensis, 90 parts of Ligusticum wallichii, 110 parts of the radix paeoniae rubrathe, 90 parts of the dried rhizome of rehmannia, 140 parts of ilex pubescens, 90 parts of safflower, ground
110 parts of dragon, 110 parts of ground beetle, 90 parts of radix scrophulariae, 90 parts of honeysuckle, 110 parts of the red sage root, 25 parts of monkshood, 90 parts of radix glycyrrhizae, the root of bidentate achyranthes 110
Part, 90 parts of ramulus mori.
It is preferred that, Chinese medicine preparation of the invention, it is made up of the bulk drug of following weight proportion：It is by following weight
The bulk drug of part proportioning：90 parts of Radix Angelicae Sinensis, 110 parts of Ligusticum wallichii, 90 parts of the radix paeoniae rubrathe, 110 parts of the dried rhizome of rehmannia, 160 parts of ilex pubescens, 110 parts of safflower, ground
90 parts of dragon, 90 parts of ground beetle, 110 parts of radix scrophulariae, 110 parts of honeysuckle, 90 parts of the red sage root, 35 parts of monkshood, 110 parts of radix glycyrrhizae, 90 parts of the root of bidentate achyranthes,
110 parts of ramulus mori.
The preparation method of the Chinese medicine preparation of present invention treatment vasculitis, it is prepared from by following processing step：
(1), by earthworm, ground beetle, ilex pubescens, radix scrophulariae, the red sage root, 80~120 mesh fine powders are ground into, it is standby；
(2), again by safflower, Radix Angelicae Sinensis, Ligusticum wallichii, the radix paeoniae rubrathe, the dried rhizome of rehmannia, monkshood, honeysuckle, radix glycyrrhizae, the root of bidentate achyranthes, ramulus mori medicinal material merges, and
Plus with medicinal material weight than the water for 8~11 times of amounts, decoct 1~3 time, 1~3h, is filtered every time, and merging filtrate is concentrated under reduced pressure dry
It is dry, and dried cream powder is ground into, it is standby；
(3) the fine powder in taking above-mentioned steps (1), step (2) in dried cream powder, be well mixed after, produce Traditional Chinese drug mixture, then
Add the auxiliary material commonly used in pharmacy and various different oral formulations are made, produce
As the preferred of Chinese medicine preparation of the present invention, the preparation method is prepared from by following processing step：
(1), by earthworm, ground beetle, ilex pubescens, radix scrophulariae, the red sage root, 100 mesh fine powders are ground into, it is standby；
(2), again by safflower, Radix Angelicae Sinensis, Ligusticum wallichii, the radix paeoniae rubrathe, the dried rhizome of rehmannia, monkshood, honeysuckle, radix glycyrrhizae, the root of bidentate achyranthes, ramulus mori medicinal material merges, and
Plus decocted 2 times, each 2h than the water for 10 times of amounts with medicinal material weight, filtration, merging filtrate, be concentrated under reduced pressure drying, and is ground into
Dried cream powder, it is standby；
(3) the fine powder in taking above-mentioned steps (1), step (2) in dried cream powder, be well mixed after, produce Traditional Chinese drug mixture, then
Add the auxiliary material commonly used in pharmacy and various different oral formulations are made, produce
Granule, hard capsule, tablet or pill can be made in Chinese medicine preparation of the present invention.
Granule：By gained active ingredient of Chinese herbs, with appropriate dextrin, sucrose, mix, pelletize, dry, particle is made
Agent.
Hard capsule：By gained active ingredient of Chinese herbs, suitable auxiliary material is added, granulation is encapsulated, and hard capsule is made.
Tablet：By gained active ingredient of Chinese herbs, mixed with appropriate amount of starch, dextrin, granulation is tabletted.
Pill：By gained active ingredient of Chinese herbs, pill is made with appropriate water, honey, sodium cellulose glycolate.
Each prescription source and efficacy effect are as follows in side：
Radix Angelicae Sinensis, is umbelliferae angelica Angelica sinensis (Oliv.) Diels dry root.Autumn Mo excavates,
Fibrous root and silt are removed, after moisture slightly evaporates, wisp is bundled into, upper canopy, with pyrotechnics slowly smoke-dried beancurd.Nature and flavor, sweet, acrid, warm.Work(
Effect, replenishing and activating blood, menstruction regulating and pain relieving relaxes bowel.
Ligusticum wallichii, is samphire Ligusticum wallichii Ligusticum chuanxiong Hort. dry rhizome.Summer is when on stem
Section disk significantly protrude, and excavated during purplish, remove silt, a heatable brick bed is done after solarization, then removes fibrous root.Nature and flavor, pungent, temperature.Effect, it is living
Blood gas, wind-expelling pain-stopping.
The radix paeoniae rubrathe is ranunculaceae plant Chinese herbaceous peony Paeonia lactiflora Pall. or river radix paeoniae rubrathe Paeonia veitchii
Lynch dry root.Spring, the excavation of season in autumn two, remove rhizome, fibrous root and silt, dry.Nature and flavor, it is bitter, it is slightly cold.Effect, heat-clearing is cool
Blood, blood stasis removing analgesic.
The dried rhizome of rehmannia, is scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Libosch. fresh or dried root.Autumn
Season excavates, except removing LU, fibrous root and silt, using fresh herb；Or slowly bakee glutinous rehmannia to about most probably dry.The former practises title " fresh rehmannia root ",
The latter, which practises, claims " radix rehmanniae recen ".Nature and flavor, radix rehmanniae recen：It is sweet, tremble with fear.Effect, clearing heat and cooling blood, yin-nourishing is promoted the production of body fluid.
Ilex pubescens, is Aquifoliaceae Holly ilex pubescens Ilex pubescens Hook.et Arn., is entered with root and leaf
Medicine.Whole year can adopt, and root section dries standby, leaf using fresh herb.Nature and flavor, it is bitter, put down.Effect, blood circulation and channel invigorating, swelling and pain relieving is clearing heat and detoxicating.
Safflower, is that drying for feverfew safflower Carthamus tinctorius L. is spent.Nature and flavor, pungent, temperature.Effect, it is living
Blood stimulates the menstrual flow, blood stasis removing analgesic.
Earthworm, is Ju Yin sections animal Pheretima aspergillum Pheretima aspergillum (E.Perrier), popular Pheretimatschiliensis
Pheretima vulgaris Chen, power simulation Pheretima guillelmi (Michaelsen) or the blind Pheretimatschiliensis of comb
Pheretima pectinifera Michaelsen hirudo leech.Former, which is practised, claims " wide dragon ", practises for latter three kinds and claims " Shanghai
Dragon ".Wide dragon spring to autumn is caught, and Shanghai earthworm summer catches, and belly is splitted in time, removes internal organ and silt, is cleaned, is dried
Or low temperature drying.Nature and flavor are salty, tremble with fear.Effect, heat-clearing arresting convulsion, dredging collateral is relievingd asthma, diuresis.
Ground beetle, is Corydiidae eupolyphagasinensis walker Eupolyphaga sinensis Walker or polyphagaplancyi Steleophaga
Plancyi (Boleny) female adult hirudo leech.After seizure, put and scald dead in boiling water, dry or dry.Nature and flavor are salty, tremble with fear；It is slightly poisonous.
Effect, broken stasis of blood blood, continuous muscles and bones.
Radix scrophulariae, is goatweed radix scrophulariae Scrophularia ningpoensis Hemsl. dry root.Winter cauline leaf
Excavated when withered.Rhizome, young shoot, fibrous root and silt are removed, shines or is dried to half-dried, stacking 3~6 days, be repeated several times to drying.Property
Taste, it is sweet, bitter, salty, it is slightly cold.Effect, cool blood enriching yin, purging intense heat and detonicating.
Honeysuckle, is caprifoliaceae plant honeysuckle Lonicera japonica Thunb., lonicera hypoglauca miq Lonicera
Hypoglauca Miq., Honeysuckle flower (hair calyx honeysuckle) Lonicera confusa DC. or hair style honeysuckle Lonicera
Dasystyla Rehd. dry flower or with the flower just opened.The flowers are in blossom puts preceding harvesting for early summer, dries.Nature and flavor are sweet, tremble with fear.Effect, clearly
Thermal detoxification, wind-heat dissipating.
The red sage root, is labiate red sage root Salvia miltiorrhiza Bunge. drying root and rhizome.Spring, autumn two
Season excavates, and removes silt, dries.It is bitter in taste, it is slightly cold.Effect, stasis-dispelling and pain-killing, invigorate blood circulation, relieving restlessness that clears away heart-fire.
Monkshood, is the processed goods of ranunculaceae plant rhizome of Chinese monkshood Aconitum carmichaeli Debx. root.Late June
To early August excavation, female root, fibrous root and silt are removed, practises and claims " mud monkshood ", be processed into following kinds.Nature and flavor are pungent, sweet, big heat；
It is poisonous.Effect, recuperating depleted yang, mends fire supporing yang, by wind-cold damp pathogen.
Radix glycyrrhizae, is glycyrrhizic legume Glycyrrhiza uralensis Fisch., swollen fruit Radix Glycyrrhiza
Inflata Bat. or glycyrrhiza glabra Glycyrrhiza glabra L. dry root.Spring, the excavation of season in autumn two, remove fibrous root, shine
It is dry.Nature and flavor are sweet, put down.Effect, invigorates the spleen and benefits qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.
The root of bidentate achyranthes, is amaranthaceous plant root of bidentate achyranthes Achyranthes bidentata Blume. dry root.Winter cauline leaf is withered
When excavate, remove fibrous root and silt, be bundled into wisp, shine to shriveling, top is trimmed, dried.Nature and flavor, bitter, acid, put down.Effect,
Filling liver kidney, strengthening the bones and muscles, dispelling stasis of blood and stimulating the menstrual flow is ensuringd proper downward flow of the blood.
Ramulus mori, is moraceae plants mulberry Morus alba L. spray.Nature and flavor, it is bitter, put down.Effect, wind-damp dispelling, sharp joint, OK
Aqueous vapor.
The present invention compared with prior art, has the advantages that：
Present inventor is by the Chinese medicine preparation evident in efficacy of clinical empirical summary for many years, selected medicinal material compatibility phase
Preferably, using the compatibility theory of traditional Chinese medicine monarch as guidance, above-mentioned all medicine phases are matched somebody with somebody, the effect of Synergistic is played so that be complete
Clearing heat and detoxicating, the blood circulation promoting nourishes blood in side, blood-activating analgetic, the effect tonified the liver and kidney.And full side has feature for the treatment of both principal and secondary aspect of disease, for vascular
Scorching patient has significant curative effect.And pharmacology test shows, Chinese medicine preparation of the present invention has no toxic side effect.It is clinical total effective
Rate can reach more than 90.3%, and clinical efficacy is better than control group (TONGSAIMAI PIAN), suitable for clinically large-scale promotion.
Embodiment
The following is the specific embodiment of present invention, for illustrating the skill that technical problem is solved in present specification
Art scheme, contributes to skilled artisan understands that present invention, but the realization of technical solution of the present invention is not limited to these
Embodiment.
Embodiment 1
(1), by earthworm 120g, ground beetle 120g, ilex pubescens 130g, radix scrophulariae 80g, red sage root 120g are ground into 100 mesh fine powders,
It is standby；
(2), again by Radix Angelicae Sinensis 120g, Ligusticum wallichii 80g, radix paeoniae rubrathe 120g, dried rhizome of rehmannia 120g, safflower 80g, honeysuckle 80g, monkshood 20g is sweet
Careless 120g, root of bidentate achyranthes 120g, ramulus mori 80g merge, and add with medicinal material weight than the water for 9 times of amounts, decoct 2 times, each 2h, filtration,
Merging filtrate, be concentrated under reduced pressure drying, and is ground into dried cream powder, standby；
(3) the fine powder in taking above-mentioned steps (1), step (2) in dried cream powder, be well mixed after, produce Traditional Chinese drug mixture, with
Appropriate microcrystalline cellulose, talcum powder, hydroxypropyl methyl cellulose are mixed, and are pelletized, and dry, 1000 tablets are made.
Embodiment 2
(1), by earthworm 80g, ground beetle 80g, ilex pubescens 170g, radix scrophulariae 120g, red sage root 80g are ground into 120 mesh fine powders, standby
With；
(2), again by Radix Angelicae Sinensis 80g, Ligusticum wallichii 120g, radix paeoniae rubrathe 80g, dried rhizome of rehmannia 80g, safflower 120g, honeysuckle 120g, monkshood 40g is sweet
Careless 80g, root of bidentate achyranthes 80g, ramulus mori 120g, and add with medicinal material weight than the water for 8 times of amounts, decoct 3 times, each 1h, filtration merges filter
Liquid, be concentrated under reduced pressure drying, and is ground into dried cream powder, standby；
(3) the fine powder in taking above-mentioned steps (1), step (2) in dried cream powder, be well mixed after, produce Traditional Chinese drug mixture, with
Appropriate dextrin, sucrose, are mixed, and are pelletized, and dry, 1000g granules are made.
Embodiment 3
(1), by earthworm 110g, ground beetle 90g, ilex pubescens 140g, radix scrophulariae 90g, red sage root 110g are ground into 80 mesh fine powders, standby
With；
(2) again by Radix Angelicae Sinensis 110g, Ligusticum wallichii 90g, radix paeoniae rubrathe 110g, dried rhizome of rehmannia 110g, safflower 110g, honeysuckle 110g, monkshood 35g,
Radix glycyrrhizae 90g, root of bidentate achyranthes 110g, ramulus mori 90g, and add with medicinal material weight than the water for 11 times of amounts, decoct 1 time, each 3h, filter, close
And filtrate, be concentrated under reduced pressure drying, and is ground into dried cream powder, standby；
(3) the fine powder in taking above-mentioned steps (1), step (2) in dried cream powder, be well mixed after, produce Traditional Chinese drug mixture, with
Appropriate PEG4000, PEG6000, pelletizes, and dries, 1000g pills are made.
Embodiment 4
(1), by earthworm 90g, ground beetle 110g, ilex pubescens 160g, radix scrophulariae 110g, red sage root 90g are ground into 120 mesh fine powders, standby
With；
(2) again by Radix Angelicae Sinensis 90g, Ligusticum wallichii 110g, the radix paeoniae rubrathe 90, dried rhizome of rehmannia 90g, safflower 90g, honeysuckle 90g, monkshood 25g, radix glycyrrhizae
110g, root of bidentate achyranthes 90g, ramulus mori 110g, and add the water with medicinal material weight than 9 times of amounts, decoct 2 times, each 2h, filtration, merging filtrate,
Be concentrated under reduced pressure drying, and is ground into dried cream powder, standby；
(3) the fine powder in taking above-mentioned steps (1), step (2) in dried cream powder, be well mixed after, produce Traditional Chinese drug mixture, with
Appropriate microcrystalline cellulose, lactose, are mixed, and are pelletized, and dry, 1000 Diskets are made.
Embodiment 5
(1), by earthworm 100g, ground beetle 100g, ilex pubescens 150g, radix scrophulariae 100g, red sage root 100g are ground into 80 mesh fine powders,
It is standby；
(2) again by Radix Angelicae Sinensis 100g, Ligusticum wallichii 100g, radix paeoniae rubrathe 100g, dried rhizome of rehmannia 100g, safflower 100g, honeysuckle 100g, monkshood
30g, radix glycyrrhizae 100g, root of bidentate achyranthes 100g, ramulus mori 100g, and add with medicinal material weight than the water for 10 times of amounts, decoct 2 times, each 2h, filter
Cross, merging filtrate, be concentrated under reduced pressure drying, and be ground into dried cream powder, it is standby；
(3) the fine powder in taking above-mentioned steps (1), step (2) in dried cream powder, after being well mixed, produce Traditional Chinese drug mixture with it is suitable
Dextrin, the sucrose of amount, are mixed, and are pelletized, and dry, 1000g granules are made.
Embodiment 6
(1), by earthworm 110g, ground beetle 110g, ilex pubescens 140g, radix scrophulariae 90g, red sage root 110g are ground into 100 mesh fine powders,
It is standby；
(2), again by Radix Angelicae Sinensis 110g, Ligusticum wallichii 90g, radix paeoniae rubrathe 110g, dried rhizome of rehmannia 90g, safflower 90g, honeysuckle 90g, monkshood 25g is sweet
Careless 90g, root of bidentate achyranthes 110g, ramulus mori 90g, and add with medicinal material weight than the water for 10 times of amounts, decoct 1 time, each 3h, filter, merge
Filtrate, be concentrated under reduced pressure drying, and is ground into dried cream powder, standby；
(3) the fine powder in taking above-mentioned steps (1), step (2) in dried cream powder, be well mixed after, produce Traditional Chinese drug mixture, plus
Enter suitable magnesium stearate, pelletize, it is encapsulated, 1000 hard capsules are made.
Embodiment 7
(1) by earthworm 90g, ground beetle 90g, ilex pubescens 160g, radix scrophulariae 110g, red sage root 90g, 120 mesh fine powders are ground into, it is standby
With；
(2) again by Radix Angelicae Sinensis 90g, Ligusticum wallichii 110g, radix paeoniae rubrathe 90g, dried rhizome of rehmannia 110g, safflower 110g, honeysuckle 110g, monkshood 35g,
Radix glycyrrhizae 110g, root of bidentate achyranthes 90g, ramulus mori 110g, and add with medicinal material weight than the water for 9 times of amounts, decoct 3 times, each 1h, filter, close
And filtrate, be concentrated under reduced pressure drying, and is ground into dried cream powder, standby；
(3) the fine powder in taking above-mentioned steps (1), step (2) in dried cream powder, be well mixed after, produce Traditional Chinese drug mixture, i.e.,
Traditional Chinese drug mixture is obtained, is mixed with appropriate amount of starch, dextrin, granulation is pressed into 1000 tablets.
Further to investigate the clinical efficacy of Chinese medicine preparation of the present invention, we have done corresponding clinical test, its result report
Accuse as follows：
2 clinical tests
2.1 general information
The rhomboembolia type arteries and veins formulated for 1987 with reference to peripheral vascular disease Professional Committee of CAIM
Pipe inflammation diagnostic criteria, selection observation treatment Buerger's disease 181, is randomly divided into two groups, treatment group 93, lower limb 53
Example, 40, upper limbs；It is wherein male 42, female 51；33~69 years old age, average age (47.89 ± 1.76) year, average course of disease
(3.43 ± 0.94) year；Control group 88,46, lower limb, 42, upper limbs；It is wherein male 45, female 43；At 25~71 years old age, put down
Equal age (48.13 ± 17985) year, average course of disease (2.55 ± 0.93) year；Two groups of Genders, age, the course of disease and the state of an illness are tight
Compare in terms of weight degree, no significant difference (P ＞ 0.05), with comparativity.
2.2 diagnostic criteria
The thrombosis-obstructive vessel formulated for 1987 with reference to peripheral angiopathy Professional Committee of CAIM
Inflammation diagnosis is accurate.1. male adults；2. there are the longer course of disease, Charcot's syndrome, rest pain, patient refers to (toe) end or foot hair
It is cool, acupuncture, burn, the acid cacesthesia such as swollen, numb；3. the colour of skin is pale or flush, and purple dark or livid purple, arteriopalmus weakens or disappeared
Lose, gangrene or ulcer；4. limb arteriosclerosis, aorto-arteritis, Raynaud's disease and diabetic gangrene etc., tongue nature are excluded
The thin white, deep thready pulse of light, tongue, Chinese medical discrimination belongs to blood stasis type, deficiency of Yin cold-condensing type, limbs doppler ultrasound (or Vascular Ultrasonography ripple) inspection
Look into and show：Arterial occlusion.The selection observation local dystrophia of patient's category vasculitis or ischaemic phase.
2.3 treatment method
Control group：Take TONGSAIMAI PIAN (Jiangsu Kangyuan Yangguang Pharmaceutical Co., Ltd.), be administered orally, one time 5, one day 3
It is secondary.1 month is a course for the treatment of, be even served after 3 courses for the treatment of, the clinical effectiveness after observation treatment.
The patient for the treatment of group gives the Chinese medicinal tablet prepared according to " technical scheme that 1 group of embodiment "；It is administered orally, once
5,3 times a day.1 month is a course for the treatment of, be even served after 3 courses for the treatment of, the clinical effectiveness after observation treatment.During taking medicine, suffer from
Person avoids pungent, peppery, greasy food and tealeaves and tobacco and wine.
2.4 curative effect determinate standard
With reference to《Peripheral vascular disease traditional Chinese and western medicine diagnostics》Formulate.
Recovery from illness：Suffering limb temperature, skin colour are normal, and numb, pain disappears, ulcer healing, can continuous walking 1km, without bright
Aobvious uncomfortable, limb artery rheography, color Doppler etc., which are checked, confirms that peripheral arterial occlusion stove blood supply is good；
It is effective：Suffering limb temperature, skin colour are normal, and numb, pain disappears substantially, ulcer healing or close healing,
Charcot's syndrome is obviously improved, and limb artery rheography, color Doppler etc., which are checked, confirms that limb artery blood supply is obviously improved；
Effectively：Mitigate through treatment part symptom；
It is invalid：Through treating symptom without significant improvement or aggravation.
2.5 statistical analysis
Statistical analysis is carried out to the data obtained using the softwares of SPSS 13.0, measurement data is represented with (x ± s), compares use
T is examined, and enumeration data uses χ2Examine, be that difference is statistically significant with P ＜ 0.05.
2.6 treatment results (are shown in Table 1)
1 two groups of Clinical efficacy comparisons of table
Note：Compared with after control group treatment,*P<0.05。
From table 1 it was found from clinical test results, the total effective rate for the treatment of group is respectively 90.3%, and control group is total effective
Rate is only 768.2%, and treatment group is significantly better than control group, and comparing difference has statistical significance (P ＜ 0.05).
2.7 pairs of Chinese medicine preparations of the present invention carry out animal acute toxicity test：
Experimental animal：Small white mouse, body weight 30-50g, male and female random selection；
Test method：Small white mouse 60 is taken, divides 6 groups, every group 10, starvation is after 10 hours, and every feeds 20ml sheets every time
Invention Chinese medicine preparation, in 24 hours, feeds 6 times altogether, observes 7 days, it is found that small white mouse activity is normal, non-toxic reaction, none
Example is dead.Small white mouse dosage presses kg body weight medicine calculation, and the studies above result shows, Chinese medicine preparation of the present invention is non-toxic,
Clinical medicine dose safety.
Model case
Patient 72 years old, is diagnosed as vasculitis, has a pain in the leg a few days, is not taken a turn for the better within one month in hospital, comes in here to cure
Treat, take Chinese medicine preparation of the present invention after 1 month, pain relief, the cardinal symptom of detumescence disappears, continuously take basic after 9 months
Recover recovery from illness.
Claims (6)
1. a kind of Chinese medicine preparation for treating vasculitis, it is characterised in that it is by the bulk drug of following weight：Radix Angelicae Sinensis 80
~120 parts, 80~120 parts of Ligusticum wallichii, 80~120 parts of the radix paeoniae rubrathe, 80~120 parts of the dried rhizome of rehmannia, 130~170 parts of ilex pubescens, safflower 80~
120 parts, 80~120 parts of earthworm, 80~120 parts of ground beetle, 80~120 parts of radix scrophulariae, 80~120 parts of honeysuckle, the red sage root 80~120
Part, 20~40 parts of monkshood, 80~120 parts of radix glycyrrhizae, 80~120 parts of the root of bidentate achyranthes, 80~120 parts of ramulus mori.
2. the Chinese medicine preparation of vasculitis is treated as claimed in claim 1, it is characterised in that it is by following weight
Bulk drug：100 parts of Radix Angelicae Sinensis, 100 parts of Ligusticum wallichii, 100 parts of the radix paeoniae rubrathe, 100 parts of the dried rhizome of rehmannia, 150 parts of ilex pubescens, 100 parts of safflower, earthworm 100
Part, 100 parts of ground beetle, 100 parts of radix scrophulariae, 100 parts of honeysuckle, 100 parts of the red sage root, 30 parts of monkshood, 100 parts of radix glycyrrhizae, 100 parts of the root of bidentate achyranthes,
100 parts of ramulus mori.
3. the Chinese medicine preparation of vasculitis is treated as claimed in claim 1, it is characterised in that it is by following weight
Bulk drug：120 parts of Radix Angelicae Sinensis, 80 parts of Ligusticum wallichii, 120 parts of the radix paeoniae rubrathe, 80 parts of the dried rhizome of rehmannia, 130 parts of ilex pubescens, 80 parts of safflower, 120 parts of earthworm,
120 parts of ground beetle, 80 parts of radix scrophulariae, 80 parts of honeysuckle, 120 parts of the red sage root, 20 parts of monkshood, 80 parts of radix glycyrrhizae, 120 parts of the root of bidentate achyranthes, ramulus mori 80
Part.
4. the Chinese medicine preparation of vasculitis is treated as claimed in claim 1, it is characterised in that it is by following weight
Bulk drug：80 parts of Radix Angelicae Sinensis, 120 parts of Ligusticum wallichii, 80 parts of the radix paeoniae rubrathe, 120 parts of the dried rhizome of rehmannia, 170 parts of ilex pubescens, 120 parts of safflower, 80 parts of earthworm,
80 parts of ground beetle, 120 parts of radix scrophulariae, 120 parts of honeysuckle, 80 parts of the red sage root, 40 parts of monkshood, 120 parts of radix glycyrrhizae, 80 parts of the root of bidentate achyranthes, ramulus mori 120
Part.
5. the preparation method of the Chinese medicine preparation of the treatment vasculitis as described in claim 1-4 is any, it is characterised in that the system
Preparation Method processing step is as follows：
(1), by earthworm, ground beetle, ilex pubescens, radix scrophulariae, the red sage root, 80~120 mesh fine powders are ground into, it is standby；
(2), again by safflower, Radix Angelicae Sinensis, Ligusticum wallichii, the radix paeoniae rubrathe, the dried rhizome of rehmannia, monkshood, honeysuckle, radix glycyrrhizae, the root of bidentate achyranthes, ramulus mori medicinal material merges, and add with
Medicinal material weight is decocted 1~3 time, 1~3h, is filtered, merging filtrate, be concentrated under reduced pressure drying every time than the water for 8~11 times of amounts, and
Dried cream powder is ground into, it is standby；
(3) the fine powder in taking above-mentioned steps (1), step (2) in dried cream powder, be well mixed after, produce Traditional Chinese drug mixture, add
Various different oral formulations are made in the auxiliary material commonly used in pharmacy, produce.
6. the preparation method of the Chinese medicine preparation of vasculitis is treated as claimed in claim 5, it is characterised in that the preparation method
Processing step is as follows：
(1), by earthworm, ground beetle, ilex pubescens, radix scrophulariae, the red sage root, 100 mesh fine powders are ground into, it is standby；
(2), again by safflower, Radix Angelicae Sinensis, Ligusticum wallichii, the radix paeoniae rubrathe, the dried rhizome of rehmannia, monkshood, honeysuckle, radix glycyrrhizae, the root of bidentate achyranthes, ramulus mori medicinal material merges, and add with
Medicinal material weight is decocted 2 times, each 2h than the water for 10 times of amounts, filtration, merging filtrate, and be concentrated under reduced pressure drying, and is ground into dry cream
Powder, it is standby；
(3) the fine powder in taking above-mentioned steps (1), step (2) in dried cream powder, be well mixed after, produce Traditional Chinese drug mixture, add
Various different oral formulations are made in the auxiliary material commonly used in pharmacy, produce.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024061140A1 (en) * | 2022-09-23 | 2024-03-28 | 上海市中西医结合医院 | Traditional chinese medicine composition for treating immune vasculitis and formulation and use thereof |
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| WO2024061140A1 (en) * | 2022-09-23 | 2024-03-28 | 上海市中西医结合医院 | Traditional chinese medicine composition for treating immune vasculitis and formulation and use thereof |
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Application publication date: 20170818 |