CN107029111A - For treating weakened body resistance evil volt institute leukemogenic compound Chinese medicinal preparation and preparation method - Google Patents
For treating weakened body resistance evil volt institute leukemogenic compound Chinese medicinal preparation and preparation method Download PDFInfo
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- 238000002360 preparation method Methods 0.000 title claims abstract description 49
- 150000001875 compounds Chemical class 0.000 title claims abstract description 31
- 230000002122 leukaemogenic effect Effects 0.000 title claims abstract description 16
- 239000003814 drug Substances 0.000 claims abstract description 28
- 239000002994 raw material Substances 0.000 claims abstract description 13
- 235000003181 Panax pseudoginseng Nutrition 0.000 claims abstract description 10
- 244000131316 Panax pseudoginseng Species 0.000 claims abstract description 10
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 7
- 238000000034 method Methods 0.000 claims abstract description 6
- 241000031023 Amana edulis Species 0.000 claims abstract description 4
- 241001233914 Chelidonium majus Species 0.000 claims abstract description 4
- 240000008397 Ganoderma lucidum Species 0.000 claims abstract description 4
- 235000001637 Ganoderma lucidum Nutrition 0.000 claims abstract description 4
- 240000001659 Oldenlandia diffusa Species 0.000 claims abstract description 4
- 235000006753 Platycodon grandiflorum Nutrition 0.000 claims abstract description 4
- 240000003582 Platycodon grandiflorus Species 0.000 claims abstract description 4
- 244000197580 Poria cocos Species 0.000 claims abstract description 4
- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 4
- 241000951473 Schizonepeta Species 0.000 claims abstract description 4
- 241000195974 Selaginella Species 0.000 claims abstract description 4
- 229940068560 greater celandine Drugs 0.000 claims abstract description 4
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 4
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- 239000003826 tablet Substances 0.000 claims description 3
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- 241000165940 Houjia Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 5
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- 235000009508 confectionery Nutrition 0.000 description 10
- 208000032839 leukemia Diseases 0.000 description 10
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- 230000001225 therapeutic effect Effects 0.000 description 6
- 206010062717 Increased upper airway secretion Diseases 0.000 description 5
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- OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical compound OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
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- A61K36/074—Ganoderma
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
One kind is used to treat weakened body resistance evil volt institute leukemogenic compound Chinese medicinal preparation and preparation method.Preparation by consumption by weight than agents raw material be made：Radix pseudostellariae 6-15, rhizoma atractylodis macrocephalae 9-24, Poria cocos 9-24, ganoderma lucidum 6-15, sealwort 6-15, stir-baked RADIX PAEONIAE ALBA 9-24, pseudo-ginseng 6-15, Sculellaria barbata 9-24, oldenlandia diffusa 9-24, edible tulip 6-15, selaginella doederlleini 6-15, radix ranunculi ternati 9-24, greater celandine 9-24, balloonflower root 6-15, charred schizonepeta 6-15, windproof 4-10.Invention formulation is to boil the method for extraction using water to extract the active ingredient in material medicine, and keeps its activity, so not only can greatly improve the dissolution rate of active ingredient in medicine, and contributes to the absorption of medicine, so as to improve its bioavilability.In addition, the medicine of the present invention is pure Chinese medicine compound preparation, thus toxic side effect will not be produced after patient's long-term taking, so security is good.In addition, the preparation method technique of the present invention is simple, it is easy to operate.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, more particularly to a kind of use being made using Chinese medicine as raw material
The leukemogenic compound Chinese medicinal preparation of institute and preparation method are lied prostrate in treating weakened body resistance heresy.
Background technology
Leukaemia is also known as leukemia, is due to caused by healthy tendency internal weakness, the malicious heresy of warm are taken advantage of a weak point, turbid with heat toxin, blood stasis, phlegm
Mutually tie, human body blood trouble is basic pathogenesis, with heating, bleeding, anaemia and liver, spleen, enlargement of lymph nodes etc. for main clinical manifestation
A kind of malignant tumour of hemopoietic system.Although the types of drugs for being clinically used to treat leukaemia at present is a lot, specific aim is not
By force, and some drugs toxic side effect it is big, so this disease of leukaemia belonged to after taking for treatment caused by weakened body resistance evil volt
DeGrain for disease.
The content of the invention
It is leukemogenic for treating weakened body resistance evil volt institute it is an object of the invention to provide one kind in order to solve the above problems
Compound Chinese medicinal preparation and preparation method.
In order to achieve the above object, provided by the present invention for treating the leukemogenic compound Chinese medicinal preparation of weakened body resistance evil volt institute
By consumption by weight than agents raw material be made：
The sealwort 6-15 of 9-24 Poria cocos of the rhizoma atractylodis macrocephalae of radix pseudostellariae 6-15,9-24 ganoderma lucidum 6-15
The oldenlandia diffusa 9-24 of 6-15 Sculellaria barbata of the pseudo-ginseng of stir-baked RADIX PAEONIAE ALBA 9-24 9-24
The balloonflower root 6-15 of 6-15 radix ranunculi ternati of the selaginella doederlleini of edible tulip 6-15,9-24 greater celandine 9-24
Charred schizonepeta 6-15 windproof 4-10
It is described be used to treating weakened body resistance evil volt the preparation method of leukemogenic compound Chinese medicinal preparation be according to following step
Rapid order is carried out:
(a) the other medicines raw material in said medicine raw material in addition to pseudo-ginseng is weighed and mixed according to proportioning, so
After soak 25 minutes, decoct 30 minutes afterwards, filter and remove residue and decoction is made；
(b) pseudo-ginseng is broken into fine powder, together taken when taking with above-mentioned decoction as described compound Chinese medicinal preparation.
Described compound Chinese medicinal preparation can be made with conventional pharmaceutic adjuvant granule, tablet, capsule, syrup,
Oral liquid, pill and paste.
Provided by the present invention for treat weakened body resistance evil volt leukemogenic compound Chinese medicinal preparation extraction boiled using water
Method extracts the active ingredient in material medicine, and keeps its activity, so can not only make the dissolution of active ingredient in medicine
Degree is greatly improved, and contributes to the absorption of medicine, so as to improve its bioavilability.In addition, the medicine of the present invention is
Pure Chinese medicine compound preparation, thus toxic side effect will not be produced after patient's long-term taking, so security is good.In addition, the present invention
Preparation method technique is simple, easy to operate.
Embodiment
Leukaemia complicated symptoms, course of disease delay, complication is more.Clinical common asthenic symptoms, real example and syndrome of intermingled deficiency and excess etc..This
Fang Lifa is in righting toxic removing.The sweet slight bitter of radix pseudostellariae is put down in side, and air making-up and spleen enlivening is promoting production of body fluid and nourishing the lung, is monarch drug in a prescription.Rhizoma atractylodis macrocephalae sweetness and bitterness temperature, benefit
Gas invigorating the spleen, eliminating dampness diuresis is the key medicine of air making-up and spleen enlivening first；Ganoderma lucidum is sweet flat, invigorating qi for tranquilization；Stir-baked RADIX PAEONIAE ALBA picric acid is slightly cold, and the moon is held back in blood-nourishing,
Soft liver analgesic, suppressing liver-YANG；Sculellaria barbata is pungent cool, clearing heat and detoxicating, diuresis, swelling and pain relieving, anticancer；The sweet micro-pungent of edible tulip is cool, heat-clearing
Removing toxic substances, carbuncle that disappears dissipating bind；The sweet pungent tepor of radix ranunculi ternati, reducing phlegm and resolving masses, removing toxicity for detumescence；Balloonflower root toil is put down, eliminating the phlegm apocenosis, all medicines of the above,
Benefiting qi and nourishing blood, clearing heat and detoxicating, reducing phlegm and resolving masses is altogether ministerial drug.Poria cocos is sweet light flat, clearing damp and promoting diuresis, strengthening the spleen and reducing phlegm, antitoxic heart-soothing and sedative；It is yellow
Essence is sweet flat, boosting qi and nourishing yin, invigorating the spleen moistening lung, kidney-nourishing；The sweet slight bitter temperature of pseudo-ginseng, removing blood stasis and hemostasis, analgesic therapy of invigorating blood circulation；Oldenlandia diffusa slight bitter is sweet
Cold, clearing heat and detoxicating, dampness removing is treating stranguria；Selaginella doederlleini sweet and slightly bitter taste is puckery cool, clearing heat and detoxicating, anticancer, hemostasis；Greater celandine bitter cold, heat-clearing solution
Poison analgesic；The pungent tepor of charred schizonepeta, expels pathogenic wind from the body surface, and promoting eruption disappears sore, hemostasis, all medicines of the above, and clearing heat and detoxicating, promoting blood circulation and removing blood stasis, Li Shui disappears
It is swollen, it is adjutant.Windproof pungent sweet tepor, expels pathogenic wind from the body surface, expel endogenous wind to relieve convulsion, only convulsion, and thinking makes medicine.Our nourishing qi and blood, the promoting flow of qi and blood circulation,
Clearing damp and promoting diuresis, with detumescence, analgesic, anticancer work(, therefore suitable for the leukaemia caused by weakened body resistance evil volt.
With reference to embodiment to compound Chinese medicinal preparation provided by the present invention for treating leukaemia and preparation method thereof
It is described in detail.
Embodiment 1：
It is weight ratio by consumption that what the present embodiment was provided, which is used to treat the weakened body resistance evil volt leukemogenic compound Chinese medicinal preparation of institute,
Agents raw material be made：
It is described be used to treating weakened body resistance evil volt the preparation method of leukemogenic compound Chinese medicinal preparation be according to following step
Rapid order is carried out:
(a) the other medicines raw material in said medicine raw material in addition to pseudo-ginseng is weighed and mixed according to proportioning, so
After soak 25 minutes, decoct 30 minutes afterwards, filter and remove residue and decoction is made；
(b) pseudo-ginseng is broken into fine powder, together taken when taking with above-mentioned decoction as described compound Chinese medicinal preparation.
In addition, granule, tablet, capsule, sugar can be made with conventional pharmaceutic adjuvant in described compound Chinese medicinal preparation
Starch agent, oral liquid, pill and paste.
Embodiment 2：
It is weight ratio by consumption that what the present embodiment was provided, which is used to treat the weakened body resistance evil volt leukemogenic compound Chinese medicinal preparation of institute,
Agents raw material be made：
Preparation method be the same as Example 1.
Embodiment 3：
It is weight ratio by consumption that what the present embodiment was provided, which is used to treat the weakened body resistance evil volt leukemogenic compound Chinese medicinal preparation of institute,
Agents raw material be made：
Preparation method be the same as Example 1.
Provided by the present invention for treating the leukemogenic compound Chinese medicinal preparation of weakened body resistance evil volt institute in brown to sepia；Gas
It is light, mildly bitter flavor.In order to verify the therapeutic effect of the compound Chinese medicinal preparation, the present inventor is using above-mentioned compound Chinese medicinal preparation to 306
Patient of the example with weakened body resistance evil volt type leukaemia has carried out system clinical observation, wherein 21-30 Sui patient 82,31-40 Sui 116
Example, 41-50 Sui 108, each medication 150ml, 3 times a day, is within 120 days 1 course for the treatment of.Cure (blood altogether after 1 course of therapy
Routine inspection is normal, and bone marrow smear checks normal, and chromosome examination is normal, and cardinal symptom is obviously improved) 7, account for 2.3%；Effectively
(every laboratory examination is obviously improved, and cardinal symptom has improvement) 144, accounts for 47.1%；Invalid (every laboratory examination is unchanged,
Cardinal symptom is without improving) 155, account for 50.7%；Total effective rate is 49.3%.13 are cured altogether after 2 course of therapy, are accounted for
4.2%；Effective 222, account for 72.5%；Invalid 71, account for 23.2%；Total effective rate is 76.8%.
Meanwhile, the present inventor is analyzed the relation between therapeutic effect and age, therapeutic effect and the course for the treatment of, analysis
As a result 1, table 2 is shown in Table respectively.
Table 1：The compound Chinese medicinal preparation therapeutic effect that the present invention is provided and age correlations table
By the data x in above-mentioned table 12Method of inspection is calculated, and is as a result 0.050 ＞ P ＞ 0.025, it is possible thereby to demonstrate,prove
It is bright to take the compound Chinese medicinal preparation that provides of the present invention to treat weakened body resistance evil volt type leukaemia, to the therapeutic effect of each age group not with
Age and change.
Table 2：The compound Chinese medicinal preparation therapeutic effect that the present invention is provided and course for the treatment of relation table
By the data x in above-mentioned table 22Method of inspection is calculated, and is as a result P ＜ 0.005, it is possible thereby to prove to take this
Invent the compound Chinese medicinal preparation of offer to treat weakened body resistance evil volt type leukaemia, with going deep into for treatment, cure rate, effective percentage are bright
It is aobvious to improve.
Claims (3)
1. one kind is used to treat the leukemogenic compound Chinese medicinal preparation of weakened body resistance evil volt institute, it is characterised in that：It is described to be used to treat
Weakened body resistance evil volt leukemogenic compound Chinese medicinal preparation by consumption by weight than agents raw material be made：
The sealwort 6-15 of 9-24 Poria cocos of the rhizoma atractylodis macrocephalae of radix pseudostellariae 6-15,9-24 ganoderma lucidum 6-15
The oldenlandia diffusa 9-24 of 6-15 Sculellaria barbata of the pseudo-ginseng of stir-baked RADIX PAEONIAE ALBA 9-24 9-24
The balloonflower root 6-15 of 6-15 radix ranunculi ternati of the selaginella doederlleini of edible tulip 6-15,9-24 greater celandine 9-24
Charred schizonepeta 6-15 windproof 4-10.
2. it is a kind of it is as claimed in claim 1 be used to treating weakened body resistance evil volt leukemogenic compound Chinese medicinal preparation preparation side
Method, it is characterised in that：Described preparation method is carried out according to the following steps order:
(a) the other medicines raw material in said medicine raw material in addition to pseudo-ginseng is weighed and mixed, Ran Houjia according to proportioning
Water soak 25 minutes, afterwards decoct 30 minutes, filter and remove residue and decoction is made；
(b) pseudo-ginseng is broken into fine powder, together taken when taking with above-mentioned decoction as described compound Chinese medicinal preparation.
3. preparation method according to claim 2, it is characterised in that：Described compound Chinese medicinal preparation can be with conventional medicine
Granule, tablet, capsule, syrup, oral liquid, pill and paste are made of auxiliary material.
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Non-Patent Citations (1)
| Title |
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| 李根培: "《3000个生活中的实用偏方》", 31 January 2008, 延边大学出版社 * |
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