CN1113804A - Antianemic powder and its preparing method - Google Patents

Abstract

The present invention relates to an antianemic powder for treating anemia. It is made up by using ginseng, bighead atractylodes rhizome, poria, white peony root, tree peony bark, chuanxiong rhizome, Chinese-date, liquorice, ophiopogon root, Chinese angelica root, prepared rehmannia root, cogongrass rhizome, fresh ginger, luffa, cassia bark, schisandra fruit, drynaria rhizome, honey and dried root of Hirstue Raspberry to form its prescription, and making them pass through such procedures of pulverizing, alcohol extracting, water extracting, concentrating, mixing, alcohol precipitation, recovering alcohol, concentrating to form paste, mixing and granulating and finished product packaging. Its functions: arresting bleeding, promoting blood circulation, clearing away heat and toxic material, supplementing and tonifying blood, replenishing vital essence and qi, and its indication: various anemic diseases due to autoimmune hemolytic anemia including hemolytic and hemorrhagic anemia and dysh.

Description

Antianemic powder and its preparing method

The present invention relates to a kind of treatment anemia, especially treat anti-anemia granule of autoimmune hemolytic anemia disease and preparation method thereof, belong to Chinese patent medicine and manufacturing process thereof that pure Chinese medicine is made.

Anemia is a kind of commonly encountered diseases, at present, it is more to treat this sick medicine, the medicine of traditional Chinese traditional treatment anemia adds haemostatic medicament often on the basis of GUIPI TANG, as Herba Agrimoniae, Radix Rubiae, charred Radix Sanguisorbae, Crinis Carbonisatus, charred Petiolus Trachycarpi, Pollen Typhae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Imperatae etc., can treat the defective blood formation that hemorrhagic anemia and heart spleen cause with this medicine, but can not be in order to treat the defective blood formation that poisoning, infection, tumor, drug-induced anemia and kidney, bone marrow cause, because this medicine does not have function of detoxification, can't remove the blood poisoning element.With regard to autoimmune hemolytic anemia, because of this medicine can't be removed red cell autoantibody, so still can't suppress erythrocytic accelerating the failure, thereby can't suppress the morbidity of this disease saturating because of, can't reach the purpose for the treatment of both the principal and secondary aspects of a disease.The medicine great majority of western medical treatment autoimmune hemolytic anemia are to adopt prednisone, hydrocortisone, azathioprine, 6-sulfenyl purine, cyclophosphamide, Chlorambucil, penicillamine etc., treat this sick weak point with these medicines and be not only not reach sometimes the medication purpose, but also can upset the balance coordination effect of organism endocrine, bring unnecessary harm.

The object of the present invention is to provide a kind of anti-anemia granule for the treatment of anemia and preparation method thereof, this anti-anemia granule can be treated hemolytic anemias such as autoimmune hemolytic anemia, be applicable to diseases such as the anemia that hemorrhagic anemia, defective blood formation cause, various hemorrhages, utilize this anti-anemia granule treatment anemia not only without any side effects, but also can reach the purpose for the treatment of both the principal and secondary aspects of a disease human body.

The object of the present invention is achieved like this: the anti-anemia granule of treatment anemia comprises the flavour of a drug constituent of following percentage by weight:

Radix Ginseng 3-4%

Rhizoma Atractylodis Macrocephalae 3-4%

Poria 3-4%

Radix Paeoniae Alba 3-4%

Cortex Moutan 3-4%

Rhizoma Chuanxiong 3-4%

Fructus Jujubae 2-3%

Radix Glycyrrhizae 2-3%

Radix Ophiopogonis 2-3%

Radix Angelicae Sinensis 6-7%

Radix Rehmanniae Preparata 7-8%

Rhizoma Imperatae 7-8%

Rhizoma Zingiberis Recens 1-2%

Fructus Luffae 7-9%

Cortex Cinnamomi 1.5-2%

Fructus Schisandrae Chinensis 1.5-2%

Rhizoma Drynariae 4.5-5%

Mel 4.5-5%

Radix Seu Folium Rubi Hirsuti root 25-35%.

The preparation method of the anti-anemia granule of this programme is: the pulverizing → alcohol extraction of medical material → water carries → concentrates → merge → ethanol precipitation → recovery ethanol → be condensed into cream → mixing granulation → finished product packing.

The preparation method of concrete anti-anemia granule is:

(1), gets above-mentioned each medicine in proportion, then Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Cortex Cinnamomi, Fructus Luffae, Rhizoma Drynariae, Rhizoma Imperatae, Radix Seu Folium Rubi Hirsuti root mixed powder are broken into granule, after crossing 40 purposes sieve, in this mixed powder, mix Rhizoma Zingiberis Recens, Fructus Jujubae, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Radix Rehmanniae Preparata, and then pulverize, behind 100-120 purpose sieve, get the raw materials ready;

(2), Cortex Moutan is ground into granule, cross 120 purposes sieve then, make the Cortex Moutan powder, alcohol reflux with 60% three times is 1 gram Cortex Moutan powder 4ml ethanol with alcoholic acid amount at every turn, and return time was respectively 1 hour, 0.5 hour, 0.5 hour, filtered while hot merges three times filtrate, places;

(3), with mixed powders such as prepared Radix Ginsengs in (1), add 8 times in water amount at every turn and decoct, decoct twice altogether, decocted 30 minutes, after the filtration, merge filtrate twice, be concentrated into 1: 1(is 1 gram that 1ml filtrate is equivalent to crude drug at every turn);

(4), concentrated solution made in filtrate made in (2) and (3) is mixed, the ethanol that in cooled mixed liquor, adds 1 times of amount then, the limit edged stirs, after leaving standstill 24 hours, filter, filtrate is removed ethanol, and reclaims ethanol in order to reuse, and then adding Mel, again mixed liquor is concentrated into 1: (4-5) extractum of (being the 4-5g that every ml concentrated solution is equivalent to crude drug);

(5), with made extractum in (4), press extractum with Icing Sugar, dextrin: Icing Sugar: dextrin=1: 3: weight ratio mix homogeneously (1-1.5), make soft material, after becoming granule with 10-12 purpose sieve series, in oven dry below 80 ℃, then heavily cross 10-12 purpose sieve one time, use plastic bag sealing then, every bag 10 gram promptly gets anti-anemia granule.

Rhizoma Imperatae in this prescription, Fructus Luffae, Radix Seu Folium Rubi Hirsuti root are cooling blood for hemostasis, heat-clearing and toxic substances removing, parasite killing anthelmintic, control the losing blood of such anemia, haemolysis takes place, remove the saturating of morbidity, the subject matter that this present just Chinese and western medicine cann't be solved because of (comprising wound, poisoning, tumor, medicine, antibody, parasite, schistosomicide etc.).Promptly enrich blood with QI invigorating such as Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Rhizoma Zingiberis Recens, Fructus Jujubaes, with strengthening body resistance and dispelling evil, anger is enriched blood, battalion defends mediation, then internal organs hundred arteries and veins are all safe and sound, the method of this what is called " be close to transport back fair and unbiased centre ", the bright meaning of Shennong's Herbal its " Radix Ginseng " have " main tonifying five ZANG-organs, peace spirit, decide soul, spasmolytic throb with fear, except that pathogen " effect.Record in the modern medicine " Chinese materia medica " (by doctoral advisor professor Lei Zaiquan of Chengdu Traditional Chinese Medical College chief editor), " Radix Ginseng " has the effect of " reducing carbohydrate metabolism; promote biosynthesiss such as DNA, protein; the cholesterol regulating metabolism; promote the hemopoietic system function; alleviate the detrimental effect of radiation to hemopoietic system, have anticancer ".With Rhizoma Drynariae, Fructus Schisandrae Chinensis direct subsidy kidney, with the smart living marrow of benefit, bone strengthening, flourish sending out.With the foster lung of clearing heat in the lung Radix Ophiopogonis, source on the kidney nourishing water, the merit of this " reinforcing the mother-organ for treating deficiency of the son-organ ", with the power of assistant Rhizoma Drynariae, Fructus Schisandrae Chinensis the kidney invigorating, with kidney-Yang invigorating, the relieving restlessness mind calming, with Cortex Moutan, Cortex Cinnamomi promoting blood circulation to remove obstruction in the collateral, the analgesia blood pressure lowering is used Mel and hundred medicines, main the five internal organs various symptoms and signs of deficiency.All medicines and synthetic side, it is played, and the tool hemostasis is invigorated blood circulation, heat-clearing and toxic substances removing, parasite killing anthelmintic, kidney-Yang invigorating, replenishing vital essence and invigorating vital QI, strengthening spleen, tonifying kidney, enhance immunity, dredge the meridian passage, blood-supplementing blood-nourishing, the function of bone and muscle strengthening.

This medicine cures mainly hemolytic anemias such as autoimmunity hemolytic anemia, and hemorrhagic anemia, defective blood formation cause anemia, various hemorrhages; Also can be used as the nourishing of auxiliary treatment and the QI and blood deficiency and the old body void of various tumors.

This medicine is used 100 examples through clinical trial, treats above-mentioned each sick total effective rate and reaches 95%, its clinical observation result

Curative effect example number percentage rate

Cure 45 45%

Effective 10 10%

Produce effects 40 40%

Invalid 5 5%

This medical instrument has the sure property of medicine gentle, has no side effect treating both the principal and secondary aspects of a disease and easily making, the characteristics that cost is low.

Embodiment:

Get Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Poria, the Radix Paeoniae Alba, Cortex Moutan, each 130 gram of Rhizoma Chuanxiong by prescription, Fructus Jujubae, Radix Glycyrrhizae, Radix Ophiopogonis be 90 grams respectively, Radix Angelicae Sinensis 260 grams, Radix Rehmanniae Preparata, each 300 gram of Rhizoma Imperatae, Rhizoma Zingiberis Recens 70 grams, Fructus Luffae 300 grams, Cortex Cinnamomi, each 70 gram of Fructus Schisandrae Chinensis, Rhizoma Drynariae, each 190 gram of Mel, Radix Seu Folium Rubi Hirsuti root 120 grams.

(1), Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Cortex Cinnamomi, Fructus Luffae, Rhizoma Drynariae, Rhizoma Imperatae, Radix Seu Folium Rubi Hirsuti root mixed powder are broken into granule, after crossing 40 purposes sieve, in this mixed powder, mix Rhizoma Zingiberis Recens, Fructus Jujubae, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Radix Rehmanniae Preparata, and then pulverize, after crossing 100-120 purpose sieve, get the raw materials ready;

(2), Cortex Moutan is ground into granule, cross 120 purposes sieve then, make the Cortex Moutan powder, alcohol reflux with 60% three times is 1 gram Cortex Moutan powder 4ml ethanol with alcoholic acid amount at every turn, and return time was respectively 1 hour, 0.5 hour, 0.5 hour, filtered while hot merges three times filtrate, places;

(3), with mixed powders such as prepared Radix Ginsengs in (1), add 8 times in water amount at every turn and decoct, decoct twice altogether, decocted 30 minutes, after the filtration, merge filtrate twice, be concentrated into 1: 1(is 1 gram that 1ml filtrate is equivalent to crude drug at every turn);

(4), concentrated solution made in filtrate made in (2) and (3) is mixed, the ethanol that in cooled mixed liquor, adds 1 times of amount then, the limit edged stirs, after leaving standstill 24 hours, filtration, filtrate are removed ethanol, and reclaim ethanol in order to reuse, and then add Mel, again mixed liquor is concentrated into 1: 4.5(is 4.5 grams that every ml concentrated solution is equivalent to crude drug);

(5) with made extractum in (4), press extractum with Icing Sugar, dextrin: Icing Sugar: the weight ratio mix homogeneously of dextrin=1: 3: 1.2, make soft material, after becoming granule with 10-12 purpose sieve series, in oven dry below 80 ℃, then heavily cross 10-12 purpose sieve one time, use plastic bag sealing then, every bag 10 gram promptly gets anti-anemia granule.This anti-anemia granule cures mainly hemolytic anemias such as autoimmune hemolytic anemia, the anemia that hemorrhagic anemia, defective blood formation cause, various hemorrhages; Also can be used as the nourishing of auxiliary treatment and the QI and blood deficiency and the old body void of various tumors.The usage and the consumption of this medicine are: day clothes three times, and each one bag, taking medicine before meal usefulness is used warm water delivery service, and children's reduces by half or follows the doctor's advice.

Claims (3)

1, a kind of anti-anemia granule for the treatment of anemia is characterized in that comprising the flavour of a drug constituent of following percentage by weight:

Radix Ginseng 3-4%

Rhizoma Atractylodis Macrocephalae 3-4%

Poria 3-4%

Radix Paeoniae Alba 3-4%

Cortex Moutan 3-4%

Rhizoma Chuanxiong 3-4%

Fructus Jujubae 2-3%

Radix Glycyrrhizae 2-3%

Radix Ophiopogonis 2-3%

Radix Angelicae Sinensis 6-7%

Radix Rehmanniae Preparata 7-8%

Rhizoma Imperatae 7-8%

Rhizoma Zingiberis Recens 1-2%

Fructus Luffae 7-9%

Cortex Cinnamomi 1.5-2%

Fructus Schisandrae Chinensis 1.5-2%

Rhizoma Drynariae 4.5-5%

Mel 4.5-5%

Radix Seu Folium Rubi Hirsuti root 25-35%.

2, the preparation method of a kind of anti-anemia granule according to claim 1 is characterized in that the pulverizing → alcohol extraction → water of medical material is carried → concentrated → merge → ethanol precipitation → recovery ethanol → be condensed into cream → mixing granulation → finished product packing.

3, according to the preparation method of claim 1,2 described a kind of anti-anemia granules, it is characterized in that:

(1), gets above-mentioned each medicine in proportion, then Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Cortex Cinnamomi, Fructus Luffae, Rhizoma Drynariae, Rhizoma Imperatae, Radix Seu Folium Rubi Hirsuti root mixed powder are broken into granule, after crossing 40 purposes sieve, in this mixed powder, mix Rhizoma Zingiberis Recens, Fructus Jujubae, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Radix Rehmanniae Preparata, and then pulverize, behind 100-120 purpose sieve, get the raw materials ready;

(2), Cortex Moutan is ground into granule, cross 120 purposes sieve then, make the Cortex Moutan powder, alcohol reflux with 60% three times is 1 gram Cortex Moutan powder 4ml ethanol with alcoholic acid amount at every turn, and return time was respectively 1 hour, 0.5 hour, 0.5 hour, filtered while hot merges three times filtrate, places;

(3), with mixed powders such as prepared Radix Ginsengs in (1), add 8 times in water amount at every turn and decoct, decoct twice altogether, decocted 30 minutes, after the filtration, merge filtrate twice, be concentrated into 1: 1(is 1 gram that 1ml filtrate is equivalent to crude drug at every turn);

(4), concentrated solution made in filtrate made in (2) and (3) is mixed, the ethanol that in cooled mixed liquor, adds 1 times of amount then, the limit edged stirs, after leaving standstill 24 hours, filter, filtrate is removed ethanol, and reclaims ethanol in order to reuse, and then adding Mel, again mixed liquor is concentrated into 1: (4-5) extractum of (being the 4-5g that every ml concentrated solution is equivalent to crude drug);

(5), with made extractum in (4), press extractum with Icing Sugar, dextrin: Icing Sugar: dextrin=1: 3: weight ratio mix homogeneously (1-1.5), make soft material, after becoming granule with 10-12 purpose sieve series, in oven dry below 80 ℃, then heavily cross 10-12 purpose sieve one time, use plastic bag sealing then, every bag 10 gram promptly gets anti-anemia granule.