CN103142841A

CN103142841A - Traditional Chinese medicine composition for treating osteonecrosis of femoral head

Info

Publication number: CN103142841A
Application number: CN201310107189XA
Authority: CN
Inventors: 石欣
Original assignee: Individual
Current assignee: Zhang Haochen
Priority date: 2013-03-29
Filing date: 2013-03-29
Publication date: 2013-06-12
Anticipated expiration: 2033-03-29
Also published as: CN103142841B

Abstract

The invention provides a traditional Chinese medicine composition for treating osteonecrosis of the femoral head. The traditional Chinese medicine composition for treating the osteonecrosis of the femoral head comprises the following raw medicinal materials by weight: 50g of rhizoma cibotii, 40g of garter snake, 20g of leech, 20g of armadillidiam vulgare, 20g of scorpio, 40g of eupolyphaga, 50g of roasted tortoise plastron, 30g of pilous antler, 20g of native copper, 20g of sangusis draconis, 30g of rhizoma picrorhizae, 20g of radix bupleuri, 5g of hedyotis diffusa, 30g of radix cyathulae, 20g of radix achyranthis bidentatae, 40g of red ginseng, 40g of rhizoma drynariae, 30g of fructus psoraleae, 30g of bark of eucommia, 30g of himalayan teasel root, 30g of mastic, 30g of myrrh, 40g of safflower, 25g of parasitic loranthus, 30g of morinda officinalis, 30g of cistanche salsa, 20g of pyrola, 20g of Chinese angelica, 50g of prepared rehmannia root, 30g of epimedium, 20g of radix puerariae, 30g of radix ophiopogonis, 20g of berba aristolochiae mollissimae, 20g of obscured homalomena rhizome, 20g of garden balsam stem, 40-80g of herba siegesbeckiae, 20g of medicated leaven and 20g of large hawthorn. The traditional Chinese medicine composition has an exact curative effect through clinical verification and can be used for treating the osteonecrosis of the femoral head.

Description

A kind of Chinese medicine composition for the treatment of femur head necrosis

Technical field

The present invention relates to a kind of medicine for the treatment of femur head necrosis, be specifically related to a kind of Chinese medicine composition of the treatment femur head necrosis that is prepared from by Chinese herbal medicine.

Background technology

Femur head necrosis is called as " osteomyelitis " on the traditional Chinese medical science.The traditional Chinese medical science thinks that body has a delicate constitution, and resistance against diseases is low, and the Liver and kidney asthenia of essence and blood causes osteoporosis, is the potential cause of ischemic necrosis of femoral head.Pathological changes relates to liver,spleen,kidney.The kidney being the origin of congenital constitution, and main bone is given birth to marrow, and the strong marrow of kidney is given birth to, and marrow completely bone is hard.Otherwise marrow is withered, loses due regeneration capacity.Liver governing tendons store blood and kidney homology, both honor declines together, if liver is got involved, store blood mistake department, can not the normal regulating blood volume, the blood operation is inconsiderate, and the difficult Ji of nutrition is the key factor that causes femur head necrosis.The spleen master transports blood, dysfunction of the spleen in transportation, without the activating QI source, muscles and bones muscle all depletion of QI with life.After pathological changes occurs, bone and cartilage contusion, QI and blood is obstructed, the passages through which vital energy circulates stasis blocking, the blood obstacle, limbs lose nutrition, and regeneration and repair ability go down, thereby produce primary disease.Femur head necrosis is the pathological process of a complexity, as not treated timely and effectively in early days, will make ischemic femoral head, subside, the joint space narrows down, cause at last osteoarthrosis inflammation, necrosis, make patient's hip joint function obstacle and the paralysis of disabling, the patient is when suffering the physiology slight illness, also to suffer decocting of psychic trauma, increase white elephant also for family, unit and society.The medicine for the treatment of femur head necrosis is a lot of at present, certain therapeutic effect is also arranged, but therapeutic effect significantly seldom.

Summary of the invention

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine composition for the treatment of femur head necrosis, it is through clinical verification, determined curative effect.

the present invention is prepared from by the crude drug of following weight: Rhizoma Cibotii 50g, Zaocys 40g, Hirudo 20g, Armadillidium 20g, Scorpio 20g, eupolyphaga 40g, Carapax Et Plastrum Testudinis (processed) 50g, Cornu Cervi Pantotrichum 30g, Pyritum 20g, Sanguis Draxonis 20g, Rhizoma Picrorhizae 30g, Radix Bupleuri 20g, Herba Hedyotidis Diffusae 5g, Radix Cyathulae 30g, Radix Achyranthis Bidentatae 20g, Radix Ginseng Rubra 40g, Rhizoma Drynariae 40g, Fructus Psoraleae 30g, Cortex Eucommiae 30g, Radix Dipsaci 30g, Olibanum 30g, Myrrha 30g, Flos Carthami 40g, Herba Taxilli 25g, Radix Morindae Officinalis 30g, Herba Cistanches 30g, Herba Pyrolae 20g, Radix Angelicae Sinensis 20g, Radix Rehmanniae Preparata 50g, Herba Epimedii 30g, Radix Puerariae 20g, Radix Ophiopogonis 30g, Herba Aristolochiae Mollissimae 20g, Rhizoma Homalomenae 20g, Herba speranskiae tuberculatae 20g, Herba Siegesbeckiae 40 ~ 80g, Massa Medicata Fermentata 20g, large Fructus Crataegi 20g.

Preparation method: get above each flavor, mixing is pulverized, and adds suitable quantity of water, the general piller of making, and drying, and get final product.

Instructions of taking: an above prescription is a course for the treatment of, and take 2-3 every day, each 6-9 gram, taking medicine after meal.

The present invention can also adopt the modern pharmaceutical technology to adopt the methods such as water extraction, alcohol extraction, diafiltration, supercritical extraction of other preparation methoies such as routine to extract effective ingredient in medicine, and can add pharmaceutically the adjuvant that allows to be prepared into other dosage form, as powder, big honeyed pills, tablet, granule, capsule, drop pill, slow controlled-release target preparation etc.

The present invention's formula is to come in long-term clinical practice optimization, and in the side, all medicines share, and play altogether blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain, and temperature male wind-supplying kidney, the effect of strengthening the tendons and bones, expelling wind and removing dampness reaches the effect for the treatment of femur head necrosis, ankylosing spondylitis jointly.

The present invention is applicable to the diseases such as femur head necrosis, mandatory spondylitis, hemiplegia, intractable lumbago and skelalgia, sciatica, intervertebral disk hernia, spinal canal stenosis, amyotrophy.

Clinical data

Case

Choose case 100 examples that are diagnosed as femur head necrosis, get rid of relative similar disease, and merge the heart, cerebrovascular disease, the abnormal person of hepatic and renal function, male 58 examples wherein, female's 42 examples; Age 22-71 is between year, average 57.4 years old; The elder of the course of disease 6 years, the shortest person 3 months, I phases 29 hip wherein, II phases 34 hip, III phases 31 hip, IV phases 71 hip, totally 165 hips.By stages with reference to international bone circulation science can appointment standard: i.e. 0 phase: x line sheet, MR I, E C T are all normal, could find osteonecrosis when only the tissue in taking out femoral head carries out cut sections for microscopic examination; The I phase: X-ray film is normal, and MRI, ECT image can note abnormalities; The II phase: x line sheet, MRI, E C T all can note abnormalities, but the femoral head profile is normal; The III phase: x line sheet shows that femoral head has slightly and subsides; The IV phase: X-ray film shows that collapse of the femoral head flattens; The V phase: X-ray film shows that hip joint space narrows down.

Therapeutic Method

Adopt the medicine of the embodiment of the present invention 1 preparation, a prescription was 1 course for the treatment of, and take 2-3 every day, each 6-9 gram, taking medicine after meal.Treat observe the curative effect after 3 courses for the treatment of, avoid during treatment bearing a heavy burden, the alleviating alcohol addiction smoking cessation.

Criterion of therapeutical effect

Cure: hip joint is without pain, and lower limb are without cripetura, and function is recovered fully, and imaging examination is normal.

Take a turn for the better: the hip arthralgia obviously alleviates, and the hip joint movable function is good, and lower limb shorten less than l c m, and iconography femur head necrosis phenomenon is improved.

Invalid: the hip arthralgia is without obvious alleviation, and lower limb shorten greater than l c m, and X-ray film, C T check that femoral head becomes large or flat, and the osteonecrosis phenomenon is unchanged.

Therapeutic outcome

Therapeutic outcome such as following table:

Can be found out by above data, the present invention is to the femur head necrosis I phase, and total effective rate reaches 100%; II phase total effective rate is 94.1%; The total effective rate of III phase is 93.8%; The total effective rate of IV phase is 71.8%.By above clinical data as seen, medicine of the present invention has significant curative effect to femur head necrosis.

The specific embodiment

The present invention is further illustrated below in conjunction with embodiment.

Embodiment 1

take Rhizoma Cibotii 50g, Zaocys 40g, Hirudo 20g, Armadillidium 20g, Scorpio 20g, eupolyphaga 40g, Carapax Et Plastrum Testudinis (processed) 50g, Cornu Cervi Pantotrichum 30g, Pyritum 20g, Sanguis Draxonis 20g, Rhizoma Picrorhizae 30g, Radix Bupleuri 20g, Herba Hedyotidis Diffusae 5g, Radix Cyathulae 30g, Radix Achyranthis Bidentatae 20g, Radix Ginseng Rubra 40g, Rhizoma Drynariae 40g, Fructus Psoraleae 30g, Cortex Eucommiae 30g, Radix Dipsaci 30g, Olibanum 30g, Myrrha 30g, Flos Carthami 40g, Herba Taxilli 25g, Radix Morindae Officinalis 30g, Herba Cistanches 30g, Herba Pyrolae 20g, Radix Angelicae Sinensis 20g, Radix Rehmanniae Preparata 50g, Herba Epimedii 30g, Radix Puerariae 20g, Radix Ophiopogonis 30g, Herba Aristolochiae Mollissimae 20g, Rhizoma Homalomenae 20g, Herba speranskiae tuberculatae 20g, Herba Siegesbeckiae 40 ~ 80g, Massa Medicata Fermentata 20g, large Fructus Crataegi 20g, mixing, pulverize, add suitable quantity of water, the general piller of making, dry, and get final product.

Claims

1. Chinese medicine composition for the treatment of femur head necrosis, crude drug by following weight is prepared from: Rhizoma Cibotii 50g, Zaocys 40g, Hirudo 20g, Armadillidium 20g, Scorpio 20g, eupolyphaga 40g, Carapax Et Plastrum Testudinis (processed) 50g, Cornu Cervi Pantotrichum 30g, Pyritum 20g, Sanguis Draxonis 20g, Rhizoma Picrorhizae 30g, Radix Bupleuri 20g, Herba Hedyotidis Diffusae 5g, Radix Cyathulae 30g, Radix Achyranthis Bidentatae 20g, Radix Ginseng Rubra 40g, Rhizoma Drynariae 40g, Fructus Psoraleae 30g, Cortex Eucommiae 30g, Radix Dipsaci 30g, Olibanum 30g, Myrrha 30g, Flos Carthami 40g, Herba Taxilli 25g, Radix Morindae Officinalis 30g, Herba Cistanches 30g, Herba Pyrolae 20g, Radix Angelicae Sinensis 20g, Radix Rehmanniae Preparata 50g, Herba Epimedii 30g, Radix Puerariae 20g, Radix Ophiopogonis 30g, Herba Aristolochiae Mollissimae 20g, Rhizoma Homalomenae 20g, Herba speranskiae tuberculatae 20g, Herba Siegesbeckiae 40 ~ 80g, Massa Medicata Fermentata 20g, large Fructus Crataegi 20g.