CN105943697A - Preparation for treating varicosity and preparation method thereof - Google Patents

Preparation for treating varicosity and preparation method thereof Download PDF

Info

Publication number
CN105943697A
CN105943697A CN201610423584.2A CN201610423584A CN105943697A CN 105943697 A CN105943697 A CN 105943697A CN 201610423584 A CN201610423584 A CN 201610423584A CN 105943697 A CN105943697 A CN 105943697A
Authority
CN
China
Prior art keywords
parts
radix
cirsoid
preparation
medicament
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610423584.2A
Other languages
Chinese (zh)
Inventor
高杰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
First Affiliated Hospital Heilongjiang University Of Chinese Medicine
Original Assignee
First Affiliated Hospital Heilongjiang University Of Chinese Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by First Affiliated Hospital Heilongjiang University Of Chinese Medicine filed Critical First Affiliated Hospital Heilongjiang University Of Chinese Medicine
Priority to CN201610423584.2A priority Critical patent/CN105943697A/en
Publication of CN105943697A publication Critical patent/CN105943697A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/62Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/648Myriapods, e.g. centipedes or millipedes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/21Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233Bupleurum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286Carthamus (distaff thistle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/34Campanulaceae (Bellflower family)
    • A61K36/346Platycodon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736Prunus, e.g. plum, cherry, peach, apricot or almond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Dermatology (AREA)
  • Insects & Arthropods (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention belongs to the technical field of traditional Chinese medicine application, and particularly relates to a preparation for treating varicosity and a preparation method thereof. Aiming at the defects that when an existing medicine is used for treating varicosity, effect taking is slow, the treatment effect is poor, and certain toxic and side effects exist, the preparation is provided and prepared from, by weight, 15-200 part of milkvetch roots, 10-20 parts of radix angelica sinensis, 10-20 parts of rehmannia roots, 15-25 parts of peach kernels, 10-20 parts of safflowers, 5-15 parts of poncirus trifoliate, 5-15 parts of the root of common peony, 8-15 parts of radix bupleuri, 5-15 parts of liquorice roots, 5-15 parts of radix platycodi, 10-15 parts of the root of bidentate achyranthes, 30-50 parts of earthworms, 8-15 parts of the rhizome of chuanxiong and 10-20 parts of centipedes. The traditional Chinese medicine decoction is prepared through a low-temperature low-pressure decocting mode, decoction dregs obtained after decocting are ground into fine powder after being dried and smashed, auxiliaries are added for external application, varicosity is treated through oral taking and external application, the treatment period is shortened, and the treatment effect is remarkable.

Description

One treats cirsoid medicament and preparation method thereof
Technical field
The invention belongs to application in TCM technical field, be specifically related to one and treat cirsoid medicament and preparation method thereof.
Background technology
Varicosis is commonly encountered diseases and the frequently-occurring disease of vascular surgery, is especially more common in and is engaged in lasting physical work or work of standing Personnel.Mainly show as the expansion of lower limb superficial vein, extend, tortuous, the symptoms such as generation suffering limb acid is swollen, weak, heavy, Severe patient is often accompanied by the complication such as ulcus cruris or superficial phlebitis.
Varicose veins of the lower extremity is due to blood stasis, and the factors such as vein tube wall is weak cause veins of lower extremity tortuous, expansion, mesh Front western medicine therapy is many with operation, thrombolytic antiinflammatory etc., the traditional Chinese medical science multiplex Orally taken and externally therapy, disease be there is no in early days to preferably treatment Method.In theory of Chinese medical science, varicose veins of the lower extremity belongs to motherland's medical science " nodular varicosity ", the category of " knee joint skin ulcer ", and its pathogenesis is prolonged Stand or undertake weight, tired wasting QI-blood;Or the mistake of sinking of QI of middle-JIAO, venation is smooth, the QI-blood circulation of impact local, addiction blood is checked Staying among channels, qi stagnation hemagglutination forms;Multiple because of damp invasion of lower energizer, toxin stimulates skin to make skin pruritus, so by finger First is scratched, and the virus such as eczema infects and induced ulcer.
Treat cirsoid medicament categories at present various, but some medicine yin-damaging and Qi consuming, damage blood vessels, toxic and side effects is big, Unsuitable life-time service;Or effect is slow, brings considerable distress to patient.
Summary of the invention
For the problems referred to above, the goal of the invention of the present invention is to provide a kind of evident in efficacy, instant effect and nontoxic special In treating cirsoid drug agents and preparation method thereof.
First technical problem that the invention solves the problems that is to provide a kind of preparation method treating cirsoid medicament.Including with Lower step:
A, by weight: Radix Astragali 150-200 part, Radix Angelicae Sinensis 10-20 part, Radix Rehmanniae 10-20 part, Semen Persicae 15-25 part, Flos Carthami 10-20 part, Fructus Aurantii 5-15 part, Radix Paeoniae Rubra 5-15 part, Radix Bupleuri 8-15 part, Radix Glycyrrhizae 5-15 part, Radix Platycodonis 5-15 part, Radix Achyranthis Bidentatae 10-15 part, Pheretima 30-50 part, Rhizoma Chuanxiong 8-15 part, Scolopendra 10-20 part weighs medicine, is ground into coarse powder;
B, step a Chinese medicine being added to the water immersion, amount of water is 3-5 times of drug weight, soaks 30-45min;
C, will soak after medicine put into vacuum type extractor, being evacuated to pressure is 0.04-0.05Mpa, decoct 30-60min, Filtration separates to obtain liquid medicine A and medicinal residues A;
D, in medicinal residues A, add 3-5 times of water of former drug weight, under the conditions of 0.04-0.05Mpa, decoct 30-60min, Filtration separates to obtain liquid medicine B and medicinal residues B;
E, liquid medicine A and liquid medicine B being mixed, obtain medical treatment after natural cooling cirsoid decoction;
F, slag A and medicinal residues B mixing of getting it filled, dry 2-3h, pulverize medicinal residues, add vaseline and essence under the conditions of 40-50 DEG C Oil, stirs, and prepares and treats cirsoid ointment.
Wherein, in the preparation method of the cirsoid medicament of above-mentioned treatment, in step a by weight: the Radix Astragali 150 parts, Radix Angelicae Sinensis 15 parts, 15 parts of the Radix Rehmanniae, 20 parts of Semen Persicae, 15 parts of Flos Carthami, Fructus Aurantii 10 parts, Radix Paeoniae Rubra 10 parts, Radix Bupleuri 10 parts, 10 parts of Radix Glycyrrhizae, Radix Platycodonis 10 parts, Radix Achyranthis Bidentatae 10 parts, Pheretima 40 parts, Rhizoma Chuanxiong 10 parts, Scolopendra 15 parts weighs medicine, pulverizes Become coarse powder.
Wherein, in the preparation method of the cirsoid medicament of above-mentioned treatment, the coarse powder described in step a was 20 mesh sieves Medicated powder.
Wherein, in the preparation method of the cirsoid medicament of above-mentioned treatment, when decocting in step c, d, temperature is 70-80 DEG C.
Wherein, in the preparation method of the cirsoid medicament of above-mentioned treatment, the pulverizing medicinal residues described in step f refer to medicinal residues It was ground into the fine powder of 200 mesh sieves.
Wherein, in the preparation method of the cirsoid medicament of above-mentioned treatment, vaseline described in step f and the addition of quintessence oil It is respectively as follows: in the medicinal residues of every weight portion addition vaseline 0.5-0.6 part, quintessence oil 0.2-0.3 part.
Wherein, in the preparation method of the cirsoid medicament of above-mentioned treatment, described in step f, in ointment, water content is 30-50%.
Present invention also offers the cirsoid medicament for the treatment of that above-mentioned preparation method obtains.
Present invention also offers the using method of a kind of cirsoid medicament of above-mentioned treatment, described decoction is directly administered orally, every day 3 times, one after each meal;Described ointment is directly applied to affected part, every day 3-5 time.
The invention have the benefit that medicine of the present invention has a heat-clearing and toxic substances removing, promoting blood circulation to restore menstrual flow, blood stasis removing pain relieving, activating QI to alleviate the depression, Dissipate blood detumescence, the function of promoting pus discharge and tissue regeneration strengthening, by cooperating between medicine and medicine, select the medicine of different content scope Carry out synergism such that it is able to effectively treat varicosis.Additionally, the present invention uses the mode that low-temp low-pressure decocts, Can effectively prevent the material that high temperature is easy to run off, improve drug effect, the decoction boiled directly is administered orally, simple and fast;The most also will Medicinal residues after boiling are aided with vaseline and quintessence oil makes ointment, directly smear affected part, clearing away heat and cooling blood, invigorate blood circulation and consolidate, and nontoxic Side effect, opens a new road for treatment varicosis.
Detailed description of the invention
The invention provides a kind of preparation method treating cirsoid medicament, comprise the following steps:
A, by weight: Radix Astragali 150-200 part, Radix Angelicae Sinensis 10-20 part, Radix Rehmanniae 10-20 part, Semen Persicae 15-25 part, Flos Carthami 10-20 part, Fructus Aurantii 5-15 part, Radix Paeoniae Rubra 5-15 part, Radix Bupleuri 8-15 part, Radix Glycyrrhizae 5-15 part, Radix Platycodonis 5-15 part, Radix Achyranthis Bidentatae 10-15 part, Pheretima 30-50 part, Rhizoma Chuanxiong 8-15 part, Scolopendra 10-20 part weighs medicine, is ground into coarse powder;
B, step a Chinese medicine being added to the water immersion, amount of water is 3-5 times of drug weight, soaks 30-45min;
C, will soak after medicine put into vacuum type extractor, being evacuated to pressure is 0.04-0.05Mpa, decoct 30-60min, Filtration separates to obtain liquid medicine A and medicinal residues A;
D, in medicinal residues A, add 3-5 times of water of former drug weight, under the conditions of 0.04-0.05Mpa, decoct 30-60min, Filtration separates to obtain liquid medicine B and medicinal residues B;
E, liquid medicine A and liquid medicine B being mixed, obtain medical treatment after natural cooling cirsoid decoction;
F, slag A and medicinal residues B mixing of getting it filled, dry 2-3h, pulverize medicinal residues, add vaseline and essence under the conditions of 40-50 DEG C Oil, stirs, and prepares and treats cirsoid ointment.
Wherein, in the preparation method of the cirsoid medicament of above-mentioned treatment, in step a by weight: the Radix Astragali 150 parts, Radix Angelicae Sinensis 15 parts, 15 parts of the Radix Rehmanniae, 20 parts of Semen Persicae, 15 parts of Flos Carthami, Fructus Aurantii 10 parts, Radix Paeoniae Rubra 10 parts, Radix Bupleuri 10 parts, 10 parts of Radix Glycyrrhizae, Radix Platycodonis 10 parts, Radix Achyranthis Bidentatae 10 parts, Pheretima 40 parts, Rhizoma Chuanxiong 10 parts, Scolopendra 15 parts weighs medicine, pulverizes Become coarse powder.
In the present invention, the Radix Astragali has an invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, and effect of expelling pus and promoting granulation is weak for the deficiency of vital energy, Anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle difficulty is burst, and bursts for a long time and does not holds back, blood deficiency and yellow complexion, Interior-heat such as is quenched one's thirst the disease;
Radix Angelicae Sinensis has replenishing and activating blood, menstruction regulating and pain relieving, effect of loosening bowel to relieve constipation, and for blood deficiency and yellow complexion, dizziness cardiopalmus, menstruation is not Adjust, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, the disease such as ulcer sores;
The Radix Rehmanniae have heat clearing away, promote the production of body fluid, moisturize, laxation, removing blood stasis with potent drugs, tissue regeneration promoting, pain relieving, regulating menstruation, the incised wound stasis of blood, removing heat from blood, hemostasis Effect;
Semen Persicae has blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, and effect of relieving cough and asthma, for amenorrhea dysmenorrhea, abdominal mass abdominal mass mass in the abdomen, lung abscess intestinal Carbuncle, injury from falling down, dryness of the intestine constipation, the disease such as cough and asthma;
Flos Carthami has promoting blood circulation to restore menstrual flow, effect of eliminating stasis to stop pain, for amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, falls and flutters Damage, skin infection such as swells and ache the disease;
Fructus Aurantii has a regulating the flow of QI to ease the stomach, effect of the stagnant relieving distension of row, stagnant for chest and diaphragm expectorant, and the feeling of stuffiness in chest is coerced swollen, food stagnation, and eructation is vomitted Inverse, weight after dysentery, proctoptosis, the disease such as uterine prolapse;
Radix Paeoniae Rubra has clearing away heat and cooling blood, effect of blood circulation promoting and blood stasis dispelling, for the stagnant amenorrhea of the stasis of blood, the accumulation of hernia abdominal mass, stomachache, hypochondriac pain, epistaxis, The diseases such as dysentery, discharging fresh blood stool, conjunctival congestion, carbuncle, injury from falling down;
Radix Bupleuri has expelling pathogenic factors from the exterior and expels the heat-evil, dispersing the stagnated live-QI to relieve the stagnation of QI, rises the effect lifting yang-energy, for stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, The diseases such as uterus comes off, menoxenia;
Radix Glycyrrhizae has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, and effect of coordinating the actions of various ingredients in a prescription, for taste void Weak, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction urgency pain, carbuncle sore tumefacting virus, cushion toxicity, Strong;
Radix Platycodonis has out lung qi dispersing gas, the effect of evacuation of pus of eliminating the phlegm, for laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery abdomen The diseases such as pain;
Radix Achyranthis Bidentatae has that blood circulation promoting and blood stasis dispelling, invigorating the liver and kidney, bone and muscle strengthening, promoting blood circulation to restore menstrual flow, ignite (blood) is descending, effect of inducing diuresis for treating stranguria syndrome;
Pheretima has effect of heat clearing away, suppressing the hyperactive liver, Zhichuan, dredging collateral, for high fanatical dry, and convulsion with spasms, headache due to pathogenic wind-heat, mesh The diseases such as red, hemiplegia;
Rhizoma Chuanxiong has effect of blood circulation promoting and blood stasis dispelling, activating QI to alleviate the depression, wind-expelling pain-stopping;
Scolopendra has effect of endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain;
Wherein, in the preparation method of the cirsoid medicament of above-mentioned treatment, the coarse powder described in step a was 20 mesh sieves Medicated powder.
Wherein, in the preparation method of the cirsoid medicament of above-mentioned treatment, when decocting in step c, d, temperature is 70-80 DEG C.
Wherein, in the preparation method of the cirsoid medicament of above-mentioned treatment, the pulverizing medicinal residues described in step f refer to medicinal residues It was ground into the fine powder of 200 mesh sieves.
Wherein, in the preparation method of the cirsoid medicament of above-mentioned treatment, vaseline described in step f and the addition of quintessence oil It is respectively as follows: in the medicinal residues of every weight portion addition vaseline 0.5-0.6 part, quintessence oil 0.2-0.3 part.
Wherein, in the preparation method of the cirsoid medicament of above-mentioned treatment, described in step f, in ointment, water content is 30-50%.
Present invention also offers the using method of a kind of cirsoid medicament of above-mentioned treatment, described decoction is directly administered orally, every day 3 times, one after each meal;Described ointment is directly applied to affected part, every day 3-5 time.
Said medicine, through long-term test, has been carried out suitable proportioning by inventor, utilizes the synergism between medicine, reaches To blood circulation promoting and blood stasis dispelling, the effect of heat radiation pain relieving, this drug agents is notable to varicose treatment effect, instant effect, and has no poison Side effect.
Below by embodiment, technical scheme is described further, but the technology contents of the present invention is not limited In the range of described in embodiment.Embodiment uses oral liquid formulation.
Embodiment 1
A, by weight Radix Astragali 150g, Radix Angelicae Sinensis 10g, Radix Rehmanniae 10g, Semen Persicae 15g, Flos Carthami 10g, Fructus Aurantii 5g, Radix Paeoniae Rubra 5g, Radix Bupleuri 8g, Radix Glycyrrhizae 5g, Radix Platycodonis 5g, Radix Achyranthis Bidentatae 10g, Pheretima 30g, Rhizoma Chuanxiong 8g, Scolopendra 10g weigh medicine, powder It is broken into coarse powder;
B, step a Chinese medicine being added to the water immersion, amount of water is 3 times of drug weight, soaks 30min;
C, will soak after medicine put into vacuum type extractor, being evacuated to pressure is 0.04Mpa, decoct 30min, filter separate Obtain liquid medicine A and medicinal residues A;
D, in medicinal residues A, add 3 times of water of former drug weight, under the conditions of 0.04Mpa, decoct 30min, filter point From obtaining liquid medicine B and medicinal residues B;
E, liquid medicine A and liquid medicine B being mixed, obtain medical treatment after natural cooling cirsoid decoction 1;
F, slag A and medicinal residues B mixing of getting it filled, dry 2h, pulverize medicinal residues, add vaseline and quintessence oil, stir under the conditions of 40 DEG C Mixing uniformly, prepare and treat cirsoid ointment 1, described vaseline is 0.5 times of medicinal residues, and described quintessence oil is the 0.2 of medicinal residues Times.
Embodiment 2
A, by weight Radix Astragali 200g, Radix Angelicae Sinensis 20g, Radix Rehmanniae 20g, Semen Persicae 25g, Flos Carthami 20g, Fructus Aurantii 15g, red Chinese herbaceous peony 15g, Radix Bupleuri 15g, Radix Glycyrrhizae 15g, Radix Platycodonis 15g, Radix Achyranthis Bidentatae 15g, Pheretima 50g, Rhizoma Chuanxiong 15g, Scolopendra 20g, claim Get it filled thing, be ground into coarse powder;
B, step a Chinese medicine being added to the water immersion, amount of water is 5 times of drug weight, soaks 45min;
C, will soak after medicine put into vacuum type extractor, being evacuated to pressure is 0.05Mpa, decoct 45min, filter separate Obtain liquid medicine A and medicinal residues A;
D, in medicinal residues A, add 5 times of water of former drug weight, under the conditions of 0.05Mpa, decoct 45min, filter point From obtaining liquid medicine B and medicinal residues B;
E, liquid medicine A and liquid medicine B being mixed, obtain medical treatment after natural cooling cirsoid decoction 2;
F, slag A and medicinal residues B mixing of getting it filled, dry 3h, pulverize medicinal residues, add vaseline and quintessence oil, stir under the conditions of 50 DEG C Mixing uniformly, prepare and treat cirsoid ointment 2, described vaseline is 0.6 times of medicinal residues, and described quintessence oil is the 0.3 of medicinal residues Times.
Embodiment 3
A, by weight Radix Astragali 150g, Radix Angelicae Sinensis 15g, Radix Rehmanniae 15g, Semen Persicae 20g, Flos Carthami 15g, Fructus Aurantii 10g, red Chinese herbaceous peony 10g, Radix Bupleuri 10g, Radix Glycyrrhizae 10g, Radix Platycodonis 10g, Radix Achyranthis Bidentatae 10g, Pheretima 40g, Rhizoma Chuanxiong 10g, Scolopendra 15g, weigh Medicine, is ground into coarse powder;
B, step a Chinese medicine being added to the water immersion, amount of water is 4 times of drug weight, soaks 45min;
C, will soak after medicine put into vacuum type extractor, being evacuated to pressure is 0.04Mpa, decoct 60min, filter separate Obtain liquid medicine A and medicinal residues A;
D, in medicinal residues A, add 4 times of water of former drug weight, under the conditions of 0.04Mpa, decoct 60min, filter point From obtaining liquid medicine B and medicinal residues B;
E, liquid medicine A and liquid medicine B being mixed, obtain medical treatment after natural cooling cirsoid decoction 3;
F, slag A and medicinal residues B mixing of getting it filled, dry 3h, pulverize medicinal residues, add vaseline and quintessence oil, stir under the conditions of 40 DEG C Mixing uniformly, prepare and treat cirsoid ointment 3, described vaseline is 0.5 times of medicinal residues, and described quintessence oil is the 0.3 of medicinal residues Times.
Illustrate that the present invention treats the beneficial effect of cirsoid drug agents below by test example.
Test example
Randomly selecting varicosis middle and late stage patient 180 people, be divided into 9 groups, often organize 20 people, the processing mode often organized is respectively See table 1:
Decoction Ointment
First group 1 Nothing
Second group 2 Nothing
3rd group 3 Nothing
4th group Nothing 1
5th group Nothing 2
6th group Nothing 3
7th group 1 1
8th group 2 2
9th group 3 3
Described decoction is daily 3 times, one after each meal, described ointment for smear once every 3h, every day 3-5 time; When treating 7-14 days, observe patient every day, pass judgment on medication effect according to sensory evaluation.
Evaluation index: invalid: CT vein is slow according to venous blood flow seen from shadow, ulcer of the lower limb, fester, the open sore part is difficult to heal; Effective: CT vein is accelerated according to venous blood flow seen from shadow, and the open sore part substantially heals, swelling, pain, weakness of the lower extremities, numbness, send out The symptom such as cool disappears substantially, and black purple, the skin of scleroma tend to normal;Cure: CT vein is unimpeded according to venous blood flow seen from shadow, Blood viscosity, platelet aggregation are remarkably decreased and recover normal value, and dead skin starts to grow normal skin, black purple, The skin of scleroma recovers smooth and elastic.
Result of the test is as shown in table 2 below:
The different medicament of table 2 is to cirsoid therapeutic effect
Model case
Chen, man, 47 years old.Double varicose veins of the lower extremity more than 7 years, during erect position, the visible bending of leg increases thick superficial vein blood Pipe, exceeds skin, can disappear, often have swollen, the fatiguability of shank acid etc. after leg is raised or put down and crouches.Lower-left over nearly two months Limb local skin is rubescent, purpling, red tongue, and tongue is the thickest greasy, deep-slow pulse.With the use of decoction and the ointment of the present invention, 3 After it, pain disappears substantially, and the blood vessel protrusion exceeding skin alleviates.After taking one week, if all diseases are lost.Continue to take one week Gong Gu curative effect.

Claims (9)

1. the preparation method treating cirsoid medicament, it is characterised in that comprise the following steps:
A, by weight: Radix Astragali 150-200 part, Radix Angelicae Sinensis 10-20 part, Radix Rehmanniae 10-20 part, Semen Persicae 15-25 part, red Flower 10-20 part, Fructus Aurantii 5-15 part, Radix Paeoniae Rubra 5-15 part, Radix Bupleuri 8-15 part, Radix Glycyrrhizae 5-15 part, Radix Platycodonis 5-15 part, cattle Knee joint 10-15 part, Pheretima 30-50 part, Rhizoma Chuanxiong 8-15 part, Scolopendra 10-20 part weighs medicine, is ground into coarse powder;
B, the medicine of step a being added to the water immersion, amount of water is 3-5 times of drug weight, soaks 30-45min;
C, will soak after medicine put into vacuum type extractor, being evacuated to pressure is 0.04-0.05Mpa, decoct 30-60min, Filtration separates to obtain liquid medicine A and medicinal residues A;
D, in medicinal residues A, add 3-5 times of water of drug weight, under the conditions of 0.04-0.05Mpa, decoct 30-60min, Filtration separates to obtain liquid medicine B and medicinal residues B;
E, liquid medicine A and liquid medicine B being mixed, obtain medical treatment after natural cooling cirsoid decoction;
F, slag A and medicinal residues B mixing of getting it filled, dry 2-3h, pulverize medicinal residues, add vaseline and quintessence oil under the conditions of 40-50 DEG C, Stir, prepare and treat cirsoid ointment.
The preparation method of the cirsoid medicament for the treatment of the most according to claim 1, it is characterised in that: step a is pressed Parts by weight: the Radix Astragali 150 parts, Radix Angelicae Sinensis 15 parts, 15 parts of the Radix Rehmanniae, 20 parts of Semen Persicae, 15 parts of Flos Carthami, Fructus Aurantii 10 parts, red Chinese herbaceous peony 10 parts, Radix Bupleuri 10 parts, 10 parts of Radix Glycyrrhizae, Radix Platycodonis 10 parts, Radix Achyranthis Bidentatae 10 parts, Pheretima 40 parts, Rhizoma Chuanxiong 10 parts, Scolopendra 15 parts weigh medicine, are ground into coarse powder.
The preparation method of the cirsoid medicament for the treatment of the most according to claim 1, it is characterised in that: in step a Coarse powder was the medicated powder of 20 mesh sieves.
The preparation method of the cirsoid medicament for the treatment of the most according to claim 1, it is characterised in that: step c, d During middle decoction, temperature is 70-80 DEG C.
The preparation method of the cirsoid medicament for the treatment of the most according to claim 1, it is characterised in that: institute in step f The medicinal residues of pulverizing stated refer to be ground into medicinal residues the fine powder of 200 mesh sieves.
The preparation method of the cirsoid medicament for the treatment of the most according to claim 1, it is characterised in that: institute in step f The addition stating vaseline and quintessence oil is respectively as follows: in the medicinal residues of every weight portion addition vaseline 0.5-0.6 part, quintessence oil 0.2-0.3 Part.
The preparation method of the cirsoid medicament for the treatment of the most according to claim 1, it is characterised in that: institute in step f Stating water content in ointment is 30-50%.
8. the cirsoid medicament for the treatment of prepared according to the preparation method described in any one of claim 1-7.
9. the using method treating cirsoid medicament, it is characterised in that: described decoction is directly administered orally, described ointment It is directly applied to affected part.
CN201610423584.2A 2016-06-15 2016-06-15 Preparation for treating varicosity and preparation method thereof Pending CN105943697A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610423584.2A CN105943697A (en) 2016-06-15 2016-06-15 Preparation for treating varicosity and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610423584.2A CN105943697A (en) 2016-06-15 2016-06-15 Preparation for treating varicosity and preparation method thereof

Publications (1)

Publication Number Publication Date
CN105943697A true CN105943697A (en) 2016-09-21

Family

ID=56905548

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610423584.2A Pending CN105943697A (en) 2016-06-15 2016-06-15 Preparation for treating varicosity and preparation method thereof

Country Status (1)

Country Link
CN (1) CN105943697A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111150761A (en) * 2020-03-11 2020-05-15 云南西草资源开发有限公司 Traditional Chinese medicine external application agent for treating varicosity

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101204440A (en) * 2007-12-17 2008-06-25 孙丹凤 Medicine for varicosity
CN103860741A (en) * 2012-12-13 2014-06-18 青岛信立德中药技术研究开发有限公司 Lower limb varicose vein treatment traditional Chinese medicine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101204440A (en) * 2007-12-17 2008-06-25 孙丹凤 Medicine for varicosity
CN103860741A (en) * 2012-12-13 2014-06-18 青岛信立德中药技术研究开发有限公司 Lower limb varicose vein treatment traditional Chinese medicine

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
向大雄: "补阳还五汤及其加减方的临床运用", 《湖南中医杂志》 *
张玉国,杨建英: "补阳还五汤临床运用举隅", 《实用中医药杂志》 *
邓中甲: "《方剂学》", 30 June 2008 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111150761A (en) * 2020-03-11 2020-05-15 云南西草资源开发有限公司 Traditional Chinese medicine external application agent for treating varicosity

Similar Documents

Publication Publication Date Title
CN102151325B (en) Traditional Chinese medicine for treating breast diseases
CN101612272B (en) Chinese medicine for treating rheumatism and rheumatoid diseases
CN104474471A (en) Traditional Chinese medicine composition for treating thyroid
CN105194542A (en) Bruise medicinal liquor
CN104306944A (en) Oral medicine for treating varicosities
CN104491831A (en) Traditional Chinese preparation used for treating compact sacrum and ilium arthritis and preparation method of traditional Chinese preparation
CN102698201B (en) Chinese medicine for treating varicocele
CN104383514A (en) Traditional Chinese medicine for treating cervical cancer
CN104225486A (en) Traditional Chinese medicine for treating chronic cholecystitis
CN103638231A (en) Medicament for treating urticaria and preparation method of medicine
CN105943697A (en) Preparation for treating varicosity and preparation method thereof
CN103520656A (en) Traditional Chinese medicine composition for treating pancreatic cancer
CN104888104A (en) Pharmaceutical composition for nursing and treating varicose veins and preparation method of pharmaceutical composition
CN105770691A (en) Medicinal preparation for treating cervical cancer and application thereof
CN104083548A (en) Traditional Chinese medicinal composition for treating ovarian cyst and preparation method thereof
CN103536674A (en) Medicament composition capable of preventing melanin tumor
CN107854589A (en) A kind of Chinese medicine composition for treating male-female deficiency syndrome and preparation method thereof
CN104257813B (en) A kind of Chinese medicine composition of QI and blood regulating and preparation method thereof
CN103285360B (en) Traditional Chinese medicinal preparation for treating thromboangiitis obliterans, and preparation method thereof
CN103638448B (en) Medicine used for treating rheumatoid arthritis, and preparation method thereof
CN104888148A (en) Medicament for chronic hepatitis B
CN105169111A (en) Traditional Chinese medicine composition for treating chronic urticaria and application of traditional Chinese medicine composition
CN105688075A (en) Novel oral preparation for treating stomachache and preparation method thereof
CN105288486A (en) Uterine fibroid treating traditional Chinese medicine composition
CN104491719A (en) Traditional Chinese medicine composition for treating cervical cancers

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20160921

WD01 Invention patent application deemed withdrawn after publication