CN103393797B - Chinese medicine composition for the treatment of menalgia and preparation method thereof - Google Patents
Chinese medicine composition for the treatment of menalgia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses Chinese medicine composition for the treatment of menalgia and preparation method thereof.Comprise: Flos Rosae Chinensis 25-40 part, Vittaria fudzinoi Mak. 25-40 part, Caulis Perillae 25-40 part, Cornu Cervi Degelatinatum 10-20 part, Radix seu Caulis Embeliae Parviflorae 10-20 part, Cladonia alpestris (L.) Rabenh. 10-20 part, Radix Sanguisorbae Filiformis 6-13 part, Fluoritum 5-11 part.Chinese medicine composition of the present invention can be prepared into any one acceptable oral drug preparation clinically according to Chinese medicine conventional formulation method.Chinese medicine composition of the present invention has regulating qi-flowing for activating stagnancy blood stasis dispelling, dispelling cold by warming the meridian pain relieving, effect of benefiting QI and nourishing blood regulating menstruation, and clinical efficacy shows that Chinese medicine composition of the present invention is reliable for menalgia determined curative effect, treating both the principal and secondary aspects of a disease, and clinical practice safety is without any side effects.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine composition for the treatment of menalgia and preparation method thereof, belong to the treatment by Chinese herbs field of menalgia.
Background technology
Dysmenorrhea refers to that women occurs periodically lower abdomen pain in menstrual period or through row front and back, and even pain connects waist.Divide constitutional and Secondary cases two kinds, constitutional is agenosomia official pathological changes, is generally Unmarried woman, and Secondary cases is that the pathological changes of genitals causes.The cause of disease is how relevant with endocrine factors, uterine factors and inherited genetic factors.Dysmenorrhea is shown effect with menstrual cycle, and severe patient often accompanies nausea and vomiting, dripping cold sweat, deadly cold hand and foot, even faints, and has a strong impact on work and the life of patient.
Dysmenorrhea belongs to " abdominal pain during menstruation " of the traditional Chinese medical science, causes the reason of dysmenorrhea more complicated, treats more thorny, and some traditional Chinese medical science scholars think and belong to one of TCM Gynecology three large difficult disease.Menopathy is relevant with renal function, and is also correlated with in spleen, liver, QI and blood, chong channel, conception vessel, uterus." traditional Chinese medical science thinks that the reason that dysmenorrhea occurs mainly contains two kinds, one is deficiency syndrome, i.e. " not Rong Ze pain ", and because deficient qi and blood or deficiency of both the liver and kidney cause, this kind of people should note at ordinary times adjusting and mends, benefiting qi and nourishing blood or nourishing the liver and kidney.Two is excess syndromes, i.e. " stagnation of QI and blood may bring about pain ", and because QI-blood circulation does not freely cause, this kind of people should dispel silt pain relieving.Pathogenesis is blockage of main and collateral channels mainly.
At present, the Chinese patent medicine being used for the treatment of menalgia also existing all is in various degree taken effect slow, the defect such as curative effect is remarkable not, haves much room for improvement.
Summary of the invention
Technical problem to be solved by this invention be overcome existing treatment menalgia existing take effect slow, curative effect not significantly, the defect such as toxic and side effects is large, the Chinese medicine composition for the treatment of menalgia provide a kind of instant effect, determined curative effect, having no side effect;
Another technical problem to be solved by this invention is to provide a kind of method preparing above-mentioned Chinese medicine composition.
Above-mentioned technical problem to be solved by this invention is achieved through the following technical solutions:
Treat a Chinese medicine composition for menalgia, comprise each component composition of following weight portion: Flos Rosae Chinensis, Vittaria fudzinoi Mak., Caulis Perillae, Cornu Cervi Degelatinatum, Radix seu Caulis Embeliae Parviflorae, Cladonia alpestris (L.) Rabenh., Radix Sanguisorbae Filiformis, Fluoritum.
Preferably, the weight portion of each component is: Flos Rosae Chinensis 25-40 part, Vittaria fudzinoi Mak. 25-40 part, Caulis Perillae 25-40 part, Cornu Cervi Degelatinatum 10-20 part, Radix seu Caulis Embeliae Parviflorae 10-20 part, Cladonia alpestris (L.) Rabenh. 10-20 part, Radix Sanguisorbae Filiformis 6-13 part, Fluoritum 5-11 part.
Preferred, the weight portion of each component is: Flos Rosae Chinensis 25-35 part, Vittaria fudzinoi Mak. 25-35 part, Caulis Perillae 25-35 part, Cornu Cervi Degelatinatum 10-15 part, Radix seu Caulis Embeliae Parviflorae 10-15 part, Cladonia alpestris (L.) Rabenh. 10-15 part, Radix Sanguisorbae Filiformis 6-11 part, Fluoritum 5-9 part.
Most preferred, the weight portion of each component is: Flos Rosae Chinensis 30 parts, Vittaria fudzinoi Mak. 30 parts, Caulis Perillae 30 parts, Cornu Cervi Degelatinatum 13 parts, Radix seu Caulis Embeliae Parviflorae 13 parts, Cladonia alpestris (L.) Rabenh. 13 parts, Radix Sanguisorbae Filiformis 9 parts, Fluoritum 7 parts.
Flos Rosae Chinensis: different name Fols Rosae, month in and month out flower etc.Nature and flavor: sweet in the mouth, warm in nature.Return Liver Channel.Function cures mainly: promoting blood flow to regulate menstruation, subduing swelling and detoxicating.Treatment menoxenia, menalgia, osteopatia sprain, blood stasis swells and ache, ulcer sore pain.
Vittaria fudzinoi Mak.: different name Herba Poae Sphondylodis.For the herb of the flat rib Herba Vittariae Flexuosae of Vittariaceae plant.The four seasons can adopt, and clean, using fresh herb or dry.Nature and flavor: micro-hardship, tepor, nontoxic.Function cures mainly: regulate the flow of vital energy, and invigorates blood circulation, pain relieving.Treating the liver gastric qi, bones and muscles pain.
Caulis Perillae: be the stem of labiate wrinkle Folium Perillae, sharp Folium Perillae etc.Concoct: removing impurity, dry, or take advantage of fresh slices, dry.Nature and flavor: Xin Gan, tepor.Return lung, spleen channel.Function cures mainly: regulate the flow of vital energy, Shu Yu, and pain relieving is antiabortive.Control the stagnation of QI, dyspepsia, chest and diaphragm painful abdominal mass is vexed, epigastric pain, and nausea is got along well.
Cornu Cervi Degelatinatum: for the angle of animal in deer family Cervus nippon Temminck or Cervus elaphus linnaeus boil Colla cornus cervi after remaining bone slag.Nature and flavor: salty, temperature.Return liver, kidney channel.Function cures mainly: tonify deficiency, supporing yang.Control insufficiency of kidney-YANG, Deficiency and coldness of spleen and stomach, vomiting, lack of appetite and vomiting, metrostaxis, deficiency-cold of uterus.
Radix seu Caulis Embeliae Parviflorae: be root or the rattan of Myrsinacea plant Embelia parviflora Wall.Gather: the whole year can adopt, clean, section, dries.Nature and flavor: pained, temperature.Function cures mainly: promoting blood circulation to remove blood stasis, replenishing kidney, strengthening waist.Control menoxenia, amenorrhea, anemia, traumatic injury, fracture.
Cladonia alpestris (L.) Rabenh.: be the dendrimer of Cladoniaceae plant passeris montani saturati Herba Cladoniae rangiferinae.Nature and flavor: lightly seasoned, property is put down.Return liver, stomach warp.Function cures mainly: suppressing the hyperactive liver, stomach invigorating, regulating menstruation, hemostasis.Control: control vascular hypertension, have a dizzy spell, migraine, order disease, asthenia, epistaxis, leucorrhea, menoxenia.
Radix Sanguisorbae Filiformis: different name Stichopus japonicus, five female Na Bao (" Yunnan Chinese herbal medicine ").For the root of the short Radix Sanguisorbae of rosaceous plant.Gather: autumn, winter excavate.Dry.Nature and flavor: " Yunnan Chinese herbal medicine ": " pungent, temperature." function cures mainly: 1. " Yunnan Chinese herbal medicine ": " tonifying blood and regulating menstruation.Control menoxenia, infertility." 2. " choosing of Yunnan Chinese herbal medicine ": " controls dysmenorrhea.″
Fluoritum: be the Ore of halogenide class mineral fluorite, main fluorinated calcium (CaF2).After excavating, except roguing stone.Concoct: Fluoritum, except roguing stone, pounds into fragment.Nature and flavor: sweet, temperature.GUIXIN, Liver Channel.Function cures mainly: relieving palpitation, calms the nerves, lowering the adverse flow of QI, warm uterus.Control asthenia palpitation with fear, cough with dyspnea, women's sea of blood deficiency and coldness is infertile.
Chinese medicine composition of the present invention is based on the pathogenetic research of the deep layer of inventor to menalgia and Therapeutic Principle thereof, simultaneously according to inventor's clinical experience and pharmaceutical research achievement for many years, filter out regulating qi-flowing for activating stagnancy blood stasis dispelling, dispelling cold by warming the meridian pain relieving, the crude drug of benefiting QI and nourishing blood regulating menstruation, forms according to certain weight proportion prescription.
There is effect of better treatment menalgia: Semen Trigonellae 4-8 part, Radix Linderae 4-8 part, Radix Dipsaci 3-7 part, Herba Epimedii 3-7 part when adding the raw material of following weight portion further in above-mentioned Chinese medicine composition; Preferably, the weight portion of each raw material is: Semen Trigonellae 6 parts, the Radix Linderae 6 parts, Radix Dipsaci 5 parts, Herba Epimedii 5 parts.
Semen Trigonellae: the bitter bean of different name, Lu Ba, Hu Ba etc.For the seed of leguminous plant Semen Trigonellae.Nature and flavor: bitter, temperature.Return kidney, Liver Channel.Function is with curing mainly: kidney-replenishing, dispelling cold and dampness.Control colic of cold type, abdomen side of body distension, the disturbance of lower legs due to pathogenic cold and dampness, the soreness of waist of suffering from a deficiency of the kidney, sexual impotence.
The Radix Linderae: be the dried root of the canella Radix Linderae.Nature and flavor: pungent, temperature.Return spleen, lung, kidney, urinary bladder channel.Function cures mainly: pleasant, dissipating depression of QI, cold expelling, pain relieving.Control QI rising in reverse order abdominal distention, dyspepsia do not disappear, food is told in regurgitation, colic of cold type, beriberi, frequent micturition.
Radix Dipsaci: be the root of Dipsacaceae plant Radix Dipsaci or Radix Dipsaci.Nature and flavor: toil, tepor.Return Liver Channel, kidney channel.Function cures mainly: invigorating the liver and kidney, bone and muscle strengthening, blood circulation regulating.Control aching pain in waist and back, podomere flaccidity syndrome and arthralgia syndrome, fall flutter wound, damage muscle folding bone, red, metrorrhagia is leaked in fetal movement, seminal emission, leukorrhagia, carbuncle skin ulcer swell.
Herba Epimedii: be the stem and leaf of Berberidaceae plant Herba Epimedii, Epimedium sagittatum, Epimedium brevicornum.Nature and flavor: Xin Gan, temperature.Return liver, kidney channel.Function cures mainly: kidney invigorating and YANG supporting, expelling wind and removing dampness.Control impotence and seminal emission, cold caused by deficiency is sterile, frequent micturition incontinence, dyspnea and cough due to deficiency of the kidney, soreness of the waist and knees, rheumatic arthralgia, and hemiplegia, extremity are meciless.
In side of the present invention, each medicine compatibility plays regulating qi-flowing for activating stagnancy blood stasis dispelling together altogether, dispelling cold by warming the meridian pain relieving, effect of benefiting QI and nourishing blood regulating menstruation, Chinese medicine composition of the present invention is for menalgia treating both the principal and secondary aspects of a disease, clinical observation on the therapeutic effect confirms, Chinese medicine composition of the present invention is reliable for menalgia determined curative effect, true.Chinese medicine composition of the present invention is nontoxic, safe and reliable, has no adverse reaction after taking, Clinical practice safety.
The present invention's each taste crude drug used can be bought at pharmacy and obtain.
Medicine activity component of the present invention can add various adjuvants required when preparing different dosage form, such as disintegrating agent, lubricant, adhesive etc., be prepared into the suitable clinical oral administration preparation of any one with the method for Chinese medicinal of routine, described oral formulations can be pill, powder, granule, capsule, tablet, oral liquid, drop pill etc.
A kind of preparation method of Chinese medicine composition of the present invention: after being taken by described weight by each crude drug of the present invention, pulverize, sieve (can be such as 80-300 mesh sieve), to obtain final product.Certainly, after also each crude drug can being pulverized, add the adjuvant needed for preparations shaping or excipient, be conventionally prepared into capsule, tablet or pill.
The another kind of preparation method of Chinese medicine composition of the present invention: take each crude drug by described weight portion; By each crude drug soak by water, merge decoction liquor, filter, filtrate is condensed into clear paste, and add adjuvant or the excipient of preparations shaping, preparations shaping, to obtain final product.
The usage of Chinese medicine composition of the present invention and consumption: dosage of the present invention depends on the factor such as age, health status of concrete dosage form, patient.As guidance: usage and dosage: capsule, each capsule content 0.3 gram of crude drug, oral 1 to 3 at every turn, 2 times on the one 7 days is a course for the treatment of.
Detailed description of the invention
The present invention is further described below in conjunction with specific embodiment; these embodiments are only exemplary; what those skilled in the art should understand that is; can modify to the details of technical solution of the present invention and form lower without departing from the spirit and scope of the present invention or replace, but these amendments and replacement all fall within the scope of protection of the present invention.
The preparation of embodiment 1 capsule
Each crude drug (unit: g): Flos Rosae Chinensis 25, Vittaria fudzinoi Mak. 25, Caulis Perillae 25, Cornu Cervi Degelatinatum 10, Radix seu Caulis Embeliae Parviflorae 10, Cladonia alpestris (L.) Rabenh. 10, Radix Sanguisorbae Filiformis 6, Fluoritum 5 is taken by following weight; Above-mentioned each crude drug is decocted with water secondary, and add water 4 times of weight for the first time, decocts 2 hours, and add water 5 times of weight for the second time, decocts 1.5 hours; By decoction liquor merge, filter, it is 1.17-1.19(60 DEG C that filtrate is concentrated into relative density) clear paste; Merge twice clear paste, add appropriate amount of starch, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, filled capsules, to obtain final product.
The preparation of embodiment 2 capsule
Each crude drug (unit: g): Flos Rosae Chinensis 40, Vittaria fudzinoi Mak. 40, Caulis Perillae 40, Cornu Cervi Degelatinatum 20, Radix seu Caulis Embeliae Parviflorae 20, Cladonia alpestris (L.) Rabenh. 20, Radix Sanguisorbae Filiformis 13, Fluoritum 11 is taken by following weight; Above-mentioned each crude drug is decocted with water secondary, and add water 6 times of weight for the first time, decocts 2 hours, and add water 4 times of weight for the second time, decocts 1.5 hours; By decoction liquor merge, filter, it is 1.17-1.19(60 DEG C that filtrate is concentrated into relative density) clear paste; Merge twice clear paste, add appropriate amount of starch, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, filled capsules, to obtain final product.
The preparation of embodiment 3 capsule
Each crude drug (unit: g): Flos Rosae Chinensis 30, Vittaria fudzinoi Mak. 30, Caulis Perillae 30, Cornu Cervi Degelatinatum 13, Radix seu Caulis Embeliae Parviflorae 13, Cladonia alpestris (L.) Rabenh. 13, Radix Sanguisorbae Filiformis 9, Fluoritum 7 is taken by following weight; Above-mentioned each crude drug is decocted with water secondary, and add water 4 times of weight for the first time, decocts 2 hours, and add water 5 times of weight for the second time, decocts 1.5 hours; By decoction liquor merge, filter, it is 1.30-1.35(55 DEG C that filtrate is concentrated into relative density) clear paste; Merge twice clear paste, add appropriate amount of starch, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, filled capsules, to obtain final product.
The preparation of embodiment 4 capsule
Each crude drug (unit: g): Flos Rosae Chinensis 25, Vittaria fudzinoi Mak. 25, Caulis Perillae 25, Cornu Cervi Degelatinatum 10, Radix seu Caulis Embeliae Parviflorae 10, Cladonia alpestris (L.) Rabenh. 10, Radix Sanguisorbae Filiformis 6, Fluoritum 5, Semen Trigonellae 4, the Radix Linderae 4, Radix Dipsaci 3, Herba Epimedii 3 is taken by following weight; Above-mentioned each crude drug is decocted with water secondary, and add water 4 times of weight for the first time, decocts 2 hours, and add water 5 times of weight for the second time, decocts 1.5 hours; By decoction liquor merge, filter, it is 1.30-1.35(55 DEG C that filtrate is concentrated into relative density) clear paste; Merge twice clear paste, add appropriate amount of starch, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, filled capsules, to obtain final product.
The preparation of embodiment 5 capsule
Each crude drug (unit: g): Flos Rosae Chinensis 40, Vittaria fudzinoi Mak. 40, Caulis Perillae 40, Cornu Cervi Degelatinatum 20, Radix seu Caulis Embeliae Parviflorae 20, Cladonia alpestris (L.) Rabenh. 20, Radix Sanguisorbae Filiformis 13, Fluoritum 11, Semen Trigonellae 8, the Radix Linderae 8, Radix Dipsaci 7, Herba Epimedii 7 is taken by following weight; Above-mentioned each crude drug is decocted with water secondary, and add water 6 times of weight for the first time, decocts 2 hours, and add water 4 times of weight for the second time, decocts 1.5 hours; By decoction liquor merge, filter, it is 1.17-1.19(60 DEG C that filtrate is concentrated into relative density) clear paste; Merge twice clear paste, add appropriate amount of starch, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, filled capsules, to obtain final product.
The preparation of embodiment 6 capsule
Each crude drug (unit: g): Flos Rosae Chinensis 30, Vittaria fudzinoi Mak. 30, Caulis Perillae 30, Cornu Cervi Degelatinatum 13, Radix seu Caulis Embeliae Parviflorae 13, Cladonia alpestris (L.) Rabenh. 13, Radix Sanguisorbae Filiformis 9, Fluoritum 7, Semen Trigonellae 6, the Radix Linderae 6, Radix Dipsaci 5, Herba Epimedii 5 is taken by following weight; Above-mentioned each crude drug is decocted with water secondary, and add water 6 times of weight for the first time, decocts 2 hours, and add water 4 times of weight for the second time, decocts 1.5 hours; By decoction liquor merge, filter, it is 1.17-1.19(60 DEG C that filtrate is concentrated into relative density) clear paste; Merge twice clear paste, add appropriate amount of starch, mixing, dry, pulverize, add appropriate amount of ethanol and make granule, dry, granulate, filled capsules, to obtain final product.
The clinical observation on the therapeutic effect test of test example 1 traditional Chinese medicine composition for treating menalgia of the present invention
One, physical data: 120 routine patients all meet the clinical criteria of menalgia, and patient is divided into 2 groups at random, often organizes 60 examples; 2 groups of patients no significant difference on sex, age, the course of disease and coincident with severity degree of condition.
Two, trial drug
Medicine prepared by embodiment of the present invention 1-6.
Three, Therapeutic Method
120 patients are divided into 2 groups respectively at random, that is: test 1 group and test 2, often organize each 60 example, test 1 group adopt prepared by embodiment 1-3 capsule treatment, test 2 groups adopt prepared by embodiment 4-6 capsule treatment; Oral, one time 3 (0.3g crude drug/grain), 2 times on the one 7 days is a course for the treatment of, treats 3 courses for the treatment of altogether; Period in a medicine withdraws other related drugs and other treatment.
Four, efficacy assessment standard
Cure: pain disappears, and continuous 3 menstrual cycle have no recurrence;
Effective: pain relief or disappearance, but more than 3 menstrual cycle can not be maintained;
Invalid: pain has no improvement.
Five, clinical observation result
Clinical observation result is in table 1.
The clinical observation on the therapeutic effect result of the test of table 1 traditional Chinese medicine composition for treating menalgia of the present invention
Clinical observation on the therapeutic effect result shows, Chinese medicine composition of the present invention has significant curative effect for menalgia patient; Safety observations find, do not observe any clinical adverse, show Chinese medicine composition clinical practice of the present invention safely, have no side effect.
Claims (7)
1. treat the Chinese medicine composition of menalgia for one kind, it is characterized in that, be made up of each crude drug of following weight portion: Flos Rosae Chinensis 25-40 part, Vittaria fudzinoi Mak. 25-40 part, Caulis Perillae 25-40 part, Cornu Cervi Degelatinatum 10-20 part, Radix seu Caulis Embeliae Parviflorae 10-20 part, Cladonia alpestris (L.) Rabenh. 10-20 part, Radix Sanguisorbae Filiformis 6-13 part and Fluoritum 5-11 part.
2. according to Chinese medicine composition according to claim 1, it is characterized in that, the weight portion of each crude drug is: Flos Rosae Chinensis 25-35 part, Vittaria fudzinoi Mak. 25-35 part, Caulis Perillae 25-35 part, Cornu Cervi Degelatinatum 10-15 part, Radix seu Caulis Embeliae Parviflorae 10-15 part, Cladonia alpestris (L.) Rabenh. 10-15 part, Radix Sanguisorbae Filiformis 6-11 part, Fluoritum 5-9 part.
3. according to Chinese medicine composition according to claim 2, it is characterized in that, the weight portion of each crude drug is: Flos Rosae Chinensis 30 parts, Vittaria fudzinoi Mak. 30 parts, Caulis Perillae 30 parts, Cornu Cervi Degelatinatum 13 parts, Radix seu Caulis Embeliae Parviflorae 13 parts, Cladonia alpestris (L.) Rabenh. 13 parts, Radix Sanguisorbae Filiformis 9 parts, Fluoritum 7 parts.
4. treat a Chinese medicine composition for menalgia, be made up of each crude drug of following weight portion: Flos Rosae Chinensis 25-40 part, Vittaria fudzinoi Mak. 25-40 part, Caulis Perillae 25-40 part, Cornu Cervi Degelatinatum 10-20 part, Radix seu Caulis Embeliae Parviflorae 10-20 part, Cladonia alpestris (L.) Rabenh. 10-20 part, Radix Sanguisorbae Filiformis 6-13 part, Fluoritum 5-11 part, Semen Trigonellae 4-8 part, Radix Linderae 4-8 part, Radix Dipsaci 3-7 part and Herba Epimedii 3-7 part.
5. according to Chinese medicine composition according to claim 4, it is characterized in that, the weight portion of each crude drug is: Flos Rosae Chinensis 30 parts, Vittaria fudzinoi Mak. 30 parts, Caulis Perillae 30 parts, Cornu Cervi Degelatinatum 13 parts, Radix seu Caulis Embeliae Parviflorae 13 parts, Cladonia alpestris (L.) Rabenh. 13 parts, Radix Sanguisorbae Filiformis 9 parts, Fluoritum 7 parts, Semen Trigonellae 6 parts, the Radix Linderae 6 parts, Radix Dipsaci 5 parts, Herba Epimedii 5 parts.
6. prepare a method for claim 1-5 Chinese medicine composition described in any one, comprise the following steps:
(1), each crude drug is taken by described weight proportion;
(2), by each crude drug soak by water, merge decoction liquor, filter, filtrate is condensed into clear paste, adds the adjuvant of preparations shaping, preparations shaping, to obtain final product.
7. the purposes of claim 1-5 Chinese medicine composition described in any one in preparation treatment menalgia medicine.
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CN105412887A (en) * | 2015-12-29 | 2016-03-23 | 赵红 | Traditional Chinese medicine composition used for treating dysmenorrhea |
CN105412888A (en) * | 2015-12-29 | 2016-03-23 | 赵红 | Traditional Chinese medicine preparation used for treating dysmenorrhoea |
CN105381322A (en) * | 2015-12-29 | 2016-03-09 | 赵红 | Traditional Chinese medicine for treating dysmenorrhea |
CN112138121A (en) * | 2020-10-13 | 2020-12-29 | 平顶山学院 | Foot-bathing traditional Chinese medicine composition for preventing and treating kidney-qi deficiency type dysmenorrhea of women |
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