CN103721046A

CN103721046A - Drug for treating chicken Eimeria tenella

Info

Publication number: CN103721046A
Application number: CN201310508284.0A
Authority: CN
Inventors: 孙霞
Original assignee: Qingdao Huaren Technology Incubator Co Ltd
Current assignee: Qingdao Huaren Technology Incubator Co Ltd
Priority date: 2013-10-24
Filing date: 2013-10-24
Publication date: 2014-04-16

Abstract

The invention provides a drug for treating chicken Eimeria tenella. The drug comprises crude medicines such as antifebrile dichroa, rheum officinale, caulis spatholobi, sealwort, aleppo avens, madder, golden cypress, uncaria, agrimonia pilosa, radix pseudostellariae, dogwood, brucea javanica, savatier monochasma herbs, trollflower, elephantopus scaber, ginseng leaves, resina toxicodendri, lonicerae flos, szechwan chinaberry fruits, purslane, cortex acanthopanacis, spina gleditsiae, rabdosia rubescens, fructus kochiae, prepared rehmannia roots, cortex phellodendri amurense and liquorice. The drug is not prone to development of drug resistance and extremely small in toxic and side effects and has the advantages of capabilities of promoting the organism growth, enhancing the immunity, improving the disease resistance of organisms and the like, the purpose of coccidiosis prevention can be achieved, the problem of drug residues which are harmful to human bodies and hinder export of broiler chickens can be solved, in addition, the immunity of the organisms can be enhanced, the growth and the development of the chickens can be promoted, and the productivity of the chickens can be improved.

Description

The medicine that is used for the treatment of chicken Eimeria Tenella disease

Technical field

The present invention relates to herbal medicine technical field, relate in particular to a kind of medicine that is used for the treatment of chicken Eimeria Tenella disease.

Background technology

Sensu lato coccidiosis should comprise Amy otology, Yin Bao section protozoon He Roubaozi worm section toxoplasma and live meat and embrace sub-worm, in traditional habit, alleged coccidiosis is refered in particular to the protozoon of Amy otology.Chicken Eimeria Tenella disease is that the multiple coccidiosis by Eimeria parasitizes caused a kind of protozoacide in the intestinal epithelial cell of chicken.This disease is because coccidiosis parasitizes host's intestinal epithelial cell or the serious disease of harm that hepatic duct epithelium causes, in general, coccidiosis is mainly the monogony stage at its life cycle to host's harm, parasitize in host's cell, and make host cell disintegrate, and destroyed the integrity of host cell tissue, cause inflammation, hemorrhage, malfunction, the cell of disintegrate simultaneously produces toxin, causes host's self poisoning; In addition due to the destroy integrity of tissue, Chang Jifa infected by microbes, causes larger harm.When the host coccidiosis that once a large amount of Infectives are strong or several coccidiosis mixed infection, often cause serious morbidity, even cause death.And when a small amount of coccidian oocyst of host infection or pathogenic weak coccidiosis worm kind, be normally not present clinical condition of illness, and only form potentiality coccidiosis, cause the economic loss that is difficult for discovering.But this growth retardation causing due to coccidium infection, reduces the loss of the price of deed but considerably beyond the dead loss causing.Especially in intensive poultry husbandry, this disease is that a kind of world generally occurs, the most multiple, harm is serious and prevent and treat one of difficult disease, often betides the chickling of 15 age in days～50 ages in days, causes infected chicken only to digest function reduction, intestinal mucosa is hemorrhage, and Blood Physiological Indexes is abnormal, and immune function declines.Sickness rate and case fatality rate that this is sick are high, it is reported, sickness rate is 50%～70%, and case fatality rate is 20%～30%, and when serious, up to 80%, the economic loss of causing to global poultry husbandry every year reaches 1,000,000,000 pounds.

At present, the means of controlling chicken Eimeria Tenella disease mainly depend on chemical synthetic drug, and the control of coccidiosis can be traced back to nineteen thirty-five, and Herrick and Holmes declare can prevent Caecum Coccidiosis to the chicken sulphonamides of feeding first off the record.Since nineteen thirty-nine Levine formally finds sulfa drugs, the medicine with anticoccidial effect in various degree reaches hundred She's kinds, for preventing the medicine of chicken coccidiosis also to have 30 She's kinds.Continuous discovery and the application of numerous coccidiostats, for control coccidiosis provides powerful mean, played huge effect to alleviating its harm.Especially since the sixties in last century, anticoccidial drug development is more rapid, on average every two years just has a kind of new drug listing.But, due to complexity and the particularity that coccidiosis grows in host, make coccidiosis constantly occur Drug resistance, as far back as the sixties in last century, just have the appearance of drug resistance worm strain, current isolated worm strain all has Drug resistance to all coccidiostats, and shows certain cross-resistance.Due to life-time service chemicals, cause the generation of coccidiosis drug resistance, the appearance of drug-resistant worm plant makes the control fall through of coccidiosis, conventionally under medicining condition, still can break out coccidiosis, there is hemafecia and death, but the harm of coccidiosis subclinical infection is more serious, causing increases weight slows down, and price of deed rate reduces.Therefore, how preventing and treating primary disease is one of important topic of current poultry husbandry.

China's Chinese herbal medicine resource is abundant, and after using, is difficult for producing drug resistance, and toxic and side effects is minimum, also has the body growth of promotion, strengthens immunologic function and improves the advantages such as body resistance against diseases.Ubiquity due to coccidiosis drug resistance, utilize herbal control coccidiosis to manifest the good impetus, both can reach the object of control coccidiosis, also can solve the residual problem of medicine harmful, that hinder broiler outlet, immunologic function that simultaneously can also enhancing body, promote the growth promoter of chicken, improve the fertility performance of chicken.At present, domestic many scholar's research show, Chinese herbal medicine is having many advantages aspect treatment chicken Eimeria Tenella disease, as little in toxic and side effects, safe to use, drug withdrawal is not recurred, be difficult for developing immunity to drugs and producing drug residue etc., therefore, the Chinese herbal and crude drugs preparations of research and development and use anticoccidial has become the focus that people pay close attention to.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of Chinese medicine composition that is used for the treatment of chicken Eimeria Tenella disease, be difficult for producing drug resistance, toxic and side effects is minimum, also there is the body growth of promotion, strengthen immunologic function and improve the advantages such as body resistance against diseases, both can reach the object of control coccidiosis, also can solve the residual problem of medicine harmful, that hinder broiler outlet, immunologic function that simultaneously can also enhancing body, promote the growth promoter of chicken, improve the fertility performance of chicken.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine composition that is used for the treatment of chicken Eimeria Tenella disease, its crude drug comprises Radix Dichroae, Radix Et Rhizoma Rhei, Caulis Spatholobi, Rhizoma Polygonati, Radix seu Herba Gei aleppici, Radix Rubiae, Cortex Phellodendri, Ramulus Uncariae Cum Uncis, Herba Agrimoniae, Radix Pseudostellariae, Fructus Corni, Fructus Bruceae, Herba monochasmatis, Flos Trollii, Elephantopus scaber L., Folium Ginseng, Resina Toxicodendri, Flos Lonicerae, Fructus Toosendan, Herba Portulacae, Cortex Acanthopancis, Spina Gleditsiae, Rabdosia rubescens, the Fructus Kochiae, Radix Rehmanniae Preparata, Cortex Phellodendri and Radix Glycyrrhizae.

Wherein, in described Chinese medicine composition, the weight portion of each crude drug is respectively Radix Dichroae 35 weight portion～45 weight portions, Radix Et Rhizoma Rhei 70 weight portion～80 weight portions, Caulis Spatholobi 20 weight portion～30 weight portions, Rhizoma Polygonati 25 weight portion～35 weight portions, Radix seu Herba Gei aleppici 50 weight portion～60 weight portions, Radix Rubiae 15 weight portion～25 weight portions, Cortex Phellodendri 55 weight portion～65 weight portions, Ramulus Uncariae Cum Uncis 30 weight portion～40 weight portions, Herba Agrimoniae 20 weight portion～30 weight portions, Radix Pseudostellariae 30 weight portion～40 weight portions, Fructus Corni 25 weight portion～35 weight portions, Fructus Bruceae 30 weight portion～40 weight portions, Herba monochasmatis 30 weight portion～40 weight portions, Flos Trollii 20 weight portion～30 weight portions, Elephantopus scaber L. 30 weight portion～40 weight portions, Folium Ginseng 45 weight portion～55 weight portions, Resina Toxicodendri 10 weight portion～20 weight portions, Flos Lonicerae 20 weight portion～30 weight portions, Fructus Toosendan 25 weight portion～35 weight portions, Herba Portulacae 20 weight portion～30 weight portions, Cortex Acanthopancis 35 weight portion～45 weight portions, Spina Gleditsiae 20 weight portion～30 weight portions, Rabdosia rubescens 25 weight portion～35 weight portions, the Fructus Kochiae 20 weight portion～30 weight portions, Radix Rehmanniae Preparata 30 weight portion～40 weight portions, Cortex Phellodendri 20 weight portion～30 weight portions and Radix Glycyrrhizae 15 weight portion～25 weight portions.

Wherein, in described Chinese medicine composition, the weight portion of each crude drug is respectively Radix Dichroae 40 weight portion～45 weight portions, Radix Et Rhizoma Rhei 75 weight portion～80 weight portions, Caulis Spatholobi 25 weight portion～30 weight portions, Rhizoma Polygonati 30 weight portion～35 weight portions, Radix seu Herba Gei aleppici 55 weight portion～60 weight portions, Radix Rubiae 20 weight portion～25 weight portions, Cortex Phellodendri 60 weight portion～65 weight portions, Ramulus Uncariae Cum Uncis 35 weight portion～40 weight portions, Herba Agrimoniae 25 weight portion～30 weight portions, Radix Pseudostellariae 35 weight portion～40 weight portions, Fructus Corni 30 weight portion～35 weight portions, Fructus Bruceae 35 weight portion～40 weight portions, Herba monochasmatis 35 weight portion～40 weight portions, Flos Trollii 25 weight portion～30 weight portions, Elephantopus scaber L. 30 weight portion～35 weight portions, Folium Ginseng 45 weight portion～50 weight portions, Resina Toxicodendri 10 weight portion～15 weight portions, Flos Lonicerae 20 weight portion～25 weight portions, Fructus Toosendan 25 weight portion～30 weight portions, Herba Portulacae 20 weight portion～25 weight portions, Cortex Acanthopancis 35 weight portion～40 weight portions, Spina Gleditsiae 20 weight portion～25 weight portions, Rabdosia rubescens 25 weight portion～30 weight portions, the Fructus Kochiae 20 weight portion～25 weight portions, Radix Rehmanniae Preparata 30 weight portion～35 weight portions, Cortex Phellodendri 20 weight portion～25 weight portions and Radix Glycyrrhizae 15 weight portion～20 weight portions.

Wherein, in described Chinese medicine composition, the weight portion of each crude drug is respectively Radix Dichroae 35 weight portion～40 weight portions, Radix Et Rhizoma Rhei 70 weight portion～75 weight portions, Caulis Spatholobi 20 weight portion～25 weight portions, Rhizoma Polygonati 25 weight portion～30 weight portions, Radix seu Herba Gei aleppici 50 weight portion～55 weight portions, Radix Rubiae 15 weight portion～20 weight portions, Cortex Phellodendri 55 weight portion～60 weight portions, Ramulus Uncariae Cum Uncis 30 weight portion～35 weight portions, Herba Agrimoniae 20 weight portion～25 weight portions, Radix Pseudostellariae 30 weight portion～35 weight portions, Fructus Corni 25 weight portion～30 weight portions, Fructus Bruceae 30 weight portion～35 weight portions, Herba monochasmatis 30 weight portion～35 weight portions, Flos Trollii 20 weight portion～25 weight portions, Elephantopus scaber L. 35 weight portion～40 weight portions, Folium Ginseng 50 weight portion～55 weight portions, Resina Toxicodendri 15 weight portion～20 weight portions, Flos Lonicerae 25 weight portion～30 weight portions, Fructus Toosendan 30 weight portion～35 weight portions, Herba Portulacae 25 weight portion～30 weight portions, Cortex Acanthopancis 40 weight portion～45 weight portions, Spina Gleditsiae 25 weight portion～30 weight portions, Rabdosia rubescens 30 weight portion～35 weight portions, the Fructus Kochiae 25 weight portion～30 weight portions, Radix Rehmanniae Preparata 35 weight portion～40 weight portions, Cortex Phellodendri 25 weight portion～30 weight portions and Radix Glycyrrhizae 20 weight portion～25 weight portions.

Wherein, in described Chinese medicine composition, the weight portion of each crude drug is respectively Radix Dichroae 40 weight portions, Radix Et Rhizoma Rhei 75 weight portions, Caulis Spatholobi 25 weight portions, Rhizoma Polygonati 30 weight portions, Radix seu Herba Gei aleppici 55 weight portions, Radix Rubiae 20 weight portions, Cortex Phellodendri 60 weight portions, Ramulus Uncariae Cum Uncis 35 weight portions, Herba Agrimoniae 25 weight portions, Radix Pseudostellariae 35 weight portions, Fructus Corni 30 weight portions, Fructus Bruceae 35 weight portions, Herba monochasmatis 35 weight portions, Flos Trollii 25 weight portions, Elephantopus scaber L. 35 weight portions, Folium Ginseng 50 weight portions, Resina Toxicodendri 15 weight portions, Flos Lonicerae 25 weight portions, Fructus Toosendan 30 weight portions, Herba Portulacae 25 weight portions, Cortex Acanthopancis 40 weight portions, Spina Gleditsiae 25 weight portions, Rabdosia rubescens 30 weight portions, the Fructus Kochiae 25 weight portions, Radix Rehmanniae Preparata 35 weight portions, Cortex Phellodendri 25 weight portions and Radix Glycyrrhizae 20 weight portions.

The present invention also provides a kind of Chinese medicine composition decoct, and its crude drug comprises Radix Dichroae, Radix Et Rhizoma Rhei, Caulis Spatholobi, Rhizoma Polygonati, Radix seu Herba Gei aleppici, Radix Rubiae, Cortex Phellodendri, Ramulus Uncariae Cum Uncis, Herba Agrimoniae, Radix Pseudostellariae, Fructus Corni, Fructus Bruceae, Herba monochasmatis, Flos Trollii, Elephantopus scaber L., Folium Ginseng, Resina Toxicodendri, Flos Lonicerae, Fructus Toosendan, Herba Portulacae, Cortex Acanthopancis, Spina Gleditsiae, Rabdosia rubescens, the Fructus Kochiae, Radix Rehmanniae Preparata, Cortex Phellodendri and Radix Glycyrrhizae.

The present invention also provides the preparation method of above-mentioned Chinese medicine composition decoct, and it is specially:

Each component of described Chinese medicine composition is mixed in proportion, add the water with respect to 8～10 times of crude drug quality sums, after soaking 30min～1h, decoct, after intense fire is heated to seethe with excitement, slow fire maintains 1h～2h, subsequent filtration, filtering residue adds the water with respect to 5～8 times of crude drug quality sums again, after soaking 30min～1h, decoct, after intense fire is heated to seethe with excitement, slow fire maintains 1h～2h, subsequent filtration, twice filtrate merges, and medicinal liquid is concentrated into the decoct that crude drug concentration is 1g/ml.

The present invention also provides a kind of Chinese medicine composition composition powders, and its crude drug comprises Radix Dichroae, Radix Et Rhizoma Rhei, Caulis Spatholobi, Rhizoma Polygonati, Radix seu Herba Gei aleppici, Radix Rubiae, Cortex Phellodendri, Ramulus Uncariae Cum Uncis, Herba Agrimoniae, Radix Pseudostellariae, Fructus Corni, Fructus Bruceae, Herba monochasmatis, Flos Trollii, Elephantopus scaber L., Folium Ginseng, Resina Toxicodendri, Flos Lonicerae, Fructus Toosendan, Herba Portulacae, Cortex Acanthopancis, Spina Gleditsiae, Rabdosia rubescens, the Fructus Kochiae, Radix Rehmanniae Preparata, Cortex Phellodendri and Radix Glycyrrhizae.

The present invention also provides the preparation method of above-mentioned Chinese medicine composition composition powders, and it is specially:

The first step, Radix Dichroae, Radix Et Rhizoma Rhei, Radix seu Herba Gei aleppici, Radix Pseudostellariae, Fructus Bruceae, Flos Trollii, Cortex Acanthopancis, Spina Gleditsiae, Radix Rehmanniae Preparata and Cortex Phellodendri are mixed according to weight portion separately, put into pressure vessel, add the Chinese liquor with respect to 45 degree 50 degree of 3～5 times of mixture qualities, at room temperature, pressure is under the condition of 200～600MPa, pressurize 3～5 minutes, after release, filters, collect filtrate, filtering residue is standby;

Second step, the weight portion that component under She is pressed separately mixes, and further mix with the filtering residue of the first step, add the water with respect to 4～6 times of crude drug quality sums, after soaking 30min～1h, decoct, after intense fire is heated to seethe with excitement, slow fire maintains 1h～2h, subsequent filtration, filtering residue adds the water with respect to 2～3 times of crude drug quality sums again, after soaking 30min～1h, decoct, after intense fire is heated to seethe with excitement, slow fire maintains 1h～2h, subsequent filtration, twice filtrate merges, and the filtrate of collecting with the first step is mixed, concentrated except desolventizing, obtain mastic, pulverize, dry, cross 50 order～80 mesh sieves, obtain powder.

The present invention also provides a kind of feedstuff, it comprises Semen Maydis 500～600 weight portions, Semen Tritici aestivi 120～210 weight portions, Zein powder 20～25 weight portions, Oleum Glycines 10～30 weight portions, calcium hydrogen phosphate 10～15 weight portions, lysine 1.9～3 weight portions, methionine 0.5～1 weight portion, serine 0.5～1 weight portion, zinc methionine 0.2～0.5 weight portion, ferrous fumarate 0.1～0.3 weight portion, choline chloride 0.8～1 weight portion, vitamin A 0.3～0.4 weight portion, vitamin E 0.5～0.8 weight portion, vitamin C 0.6～1.0 weight portion, said herbal medicine powder feed additive 5～9 weight portions.

The present invention also provides the preparation method of above-mentioned feedstuff, and it comprises:

The first step, prepares Chinese powder medicine feed additive according to the method described above;

Second step, the material composition of getting in proportion above-mentioned feedstuff is all grouped together, putting into multiplex mixer stirs 150 minutes, after taking-up, put into ring mode pulverizer and be ground into powder, then take out and put into dehydrator, the aridity of controlling dried material is 70%～80%, the time of smoking is 50～70 minutes, putting into after removal and cooling multiplex mixer stirs 190 minutes, after taking-up, put into ring mode bulking machine expanded, control the temperature of bulking machine between 70 ℃～80 ℃, the expanded time is 1～2 hour, the aridity of controlling material to be extruded is 80%～90%, after taking-up, proceed in ring mode grit machine and be produced into and precipitate hard particles feedstuff, then by 40 meshes, sieve.

Beneficial effect of the present invention:

Chinese medicine composition provided by the invention is difficult for producing drug resistance, toxic and side effects is minimum, also there is the body growth of promotion, strengthen immunologic function and improve the advantages such as body resistance against diseases, both can reach the object of control coccidiosis, also can solve the residual problem of medicine harmful, that hinder broiler outlet, immunologic function that simultaneously can also enhancing body, promotes the growth promoter of chicken to improve the fertility performance of chicken.

The specific embodiment

Theoretical according to Chinese veterinarian, chicken coccidiosis is mostly the class disease due to diseases caused by exogenous pathogenic factor worm evil (coccidiosis), is mainly in the season of warm moist.Because of the evil impairment of blood and body fluid of worm, and the tired spleen of retention of damp-heat in the interior, therefore that the sick chicken initial stage shows as lack of appetite god is idle, arrange thin excrement, wetly in feces subsequently there is mucus, have blood in stool, thirst and liking drink, fear of cold flocks together, and cockscomb turns white, becomes thin, exhaustion is dead.Coccidiosis is dialectical by Chinese medicine is damp-heat syndrome, take effect a permanent cure, take stopgap measures, strengthening vital QI to eliminate pathogenic factors is principle, therefore take heat clearing and damp drying in treatment as main, by Chinese veterinarian's differential diagnosis in terms of eight principles, think that disease is just " excess syndrome ", be afterwards " deficiency syndrome ", therefore it is main controlling just, heat clearing and damp drying eliminating evil mainly with parasite killing, be aided with QI invigorating tonify deficiency for Therapeutic Principle.

Based on above-mentioned theory, the invention provides a kind of Chinese medicine composition that is used for the treatment of chicken Eimeria Tenella disease, its crude drug comprises Radix Dichroae, Radix Et Rhizoma Rhei, Caulis Spatholobi, Rhizoma Polygonati, Radix seu Herba Gei aleppici, Radix Rubiae, Cortex Phellodendri, Ramulus Uncariae Cum Uncis, Herba Agrimoniae, Radix Pseudostellariae, Fructus Corni, Fructus Bruceae, Herba monochasmatis, Flos Trollii, Elephantopus scaber L., Folium Ginseng, Resina Toxicodendri, Flos Lonicerae, Fructus Toosendan, Herba Portulacae, Cortex Acanthopancis, Spina Gleditsiae, Rabdosia rubescens, the Fructus Kochiae, Radix Rehmanniae Preparata, Cortex Phellodendri and Radix Glycyrrhizae.

In side, the anthelmintic of Radix Dichroae parasite killing, heat clearing and damp drying, it is containing effective ingredient halofuginone hydrobromide, effective to coccidiosis second filial generation merozoite, Radix Et Rhizoma Rhei heat and toxic materials clearing away, it has antiinflammatory parasite killing and laxative action, can promote the discharge of polypide or egg capsule, Caulis Spatholobi, Radix Rubiae hemostasis is enriched blood, Rhizoma Polygonati, Radix seu Herba Gei aleppici invigorating the spleen and replenishing QI, enhancing body resistance, Cortex Phellodendri bowel relieving dampness is got rid of enterogenous endotoxin, Fructus Bruceae is killed and is suppressed coccidiosis and expel exopathogen, Ramulus Uncariae Cum Uncis contains Ramulus Uncariae cum Uncis alkali, coccidiosis merozoite is had to inhibitory or killing effect, effective ingredient agrimophol in Herba Agrimoniae, not only anthelmintic spectrum is wide, curative effect is high, and there is schistosomicide, antiinflammatory, antivirus action, Radix Pseudostellariae replenishing QI to invigorate the spleen, there is enhancing cellular immune function, the effects such as weightening finish and raising Abwehrkraft des Koepers, Fructus Corni the liver and the kidney tonifying, there is antiinflammatory, the effects such as hemostasis and promotion nonspecific immunity and cellular immune function, Herba monochasmatis heat-clearing and toxic substances removing, cooling blood for hemostasis, Flos Trollii heat-clearing and toxic substances removing, Elephantopus scaber L. heat-clearing and toxic substances removing, inducing diuresis to remove edema, Folium Ginseng using tonifying Qi reinforcing lungs, drive away summer heat and promote the production of body fluid, Resina Toxicodendri dissipating blood stasis to promote menstruationg, eliminating stagnated food and killing intestinal worms, Flos Lonicerae heat-clearing and toxic substances removing, dispelling wind and heat pathogens, Fructus Toosendan pesticide and disinfectant, soothing the liver expelling the heat-evil, Herba Portulacae heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, Cortex Acanthopancis expelling wind and removing dampness, liver and kidney tonifying, Spina Gleditsiae detumescence poison holding, evacuation of pus, parasite killing, Rabdosia rubescens heat-clearing and toxic substances removing, promoting blood circulation and stopping pain, Fructus Kochiae clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching, the Radix Rehmanniae Preparata YIN nourishing of enriching blood, benefit essence is filled out marrow, Cortex Phellodendri heat-clearing and toxic substances removing, pathogenic fire purging is except steaming, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, all medicines share, reach parasite killing dysentery relieving, astringing to arrest diarrhea, the effect of clearing away heat and cooling blood, improve chicken autoimmunity.

The effect of the anti-Eimeria Tenella disease of Chinese medicine composition provided by the invention, the growth that suppresses coccidiosis on the one hand, on the other hand by regulate animal body immunologic function, produce nonspecific immunity with enhancing body premunition, reach and eliminate pathogen and alleviate it to histiocytic damage, recover the normal physiological function of body.

Further, described Chinese medicine composition only consists of above-mentioned raw materials medicine component.

In described Chinese medicine composition, the weight portion of each crude drug is respectively Radix Dichroae 35 weight portion～45 weight portions, Radix Et Rhizoma Rhei 70 weight portion～80 weight portions, Caulis Spatholobi 20 weight portion～30 weight portions, Rhizoma Polygonati 25 weight portion～35 weight portions, Radix seu Herba Gei aleppici 50 weight portion～60 weight portions, Radix Rubiae 15 weight portion～25 weight portions, Cortex Phellodendri 55 weight portion～65 weight portions, Ramulus Uncariae Cum Uncis 30 weight portion～40 weight portions, Herba Agrimoniae 20 weight portion～30 weight portions, Radix Pseudostellariae 30 weight portion～40 weight portions, Fructus Corni 25 weight portion～35 weight portions, Fructus Bruceae 30 weight portion～40 weight portions, Herba monochasmatis 30 weight portion～40 weight portions, Flos Trollii 20 weight portion～30 weight portions, Elephantopus scaber L. 30 weight portion～40 weight portions, Folium Ginseng 45 weight portion～55 weight portions, Resina Toxicodendri 10 weight portion～20 weight portions, Flos Lonicerae 20 weight portion～30 weight portions, Fructus Toosendan 25 weight portion～35 weight portions, Herba Portulacae 20 weight portion～30 weight portions, Cortex Acanthopancis 35 weight portion～45 weight portions, Spina Gleditsiae 20 weight portion～30 weight portions, Rabdosia rubescens 25 weight portion～35 weight portions, the Fructus Kochiae 20 weight portion～30 weight portions, Radix Rehmanniae Preparata 30 weight portion～40 weight portions, Cortex Phellodendri 20 weight portion～30 weight portions and Radix Glycyrrhizae 15 weight portion～25 weight portions.

In described Chinese medicine composition, the weight portion of each crude drug is further preferably respectively Radix Dichroae 40 weight portion～45 weight portions, Radix Et Rhizoma Rhei 75 weight portion～80 weight portions, Caulis Spatholobi 25 weight portion～30 weight portions, Rhizoma Polygonati 30 weight portion～35 weight portions, Radix seu Herba Gei aleppici 55 weight portion～60 weight portions, Radix Rubiae 20 weight portion～25 weight portions, Cortex Phellodendri 60 weight portion～65 weight portions, Ramulus Uncariae Cum Uncis 35 weight portion～40 weight portions, Herba Agrimoniae 25 weight portion～30 weight portions, Radix Pseudostellariae 35 weight portion～40 weight portions, Fructus Corni 30 weight portion～35 weight portions, Fructus Bruceae 35 weight portion～40 weight portions, Herba monochasmatis 35 weight portion～40 weight portions, Flos Trollii 25 weight portion～30 weight portions, Elephantopus scaber L. 30 weight portion～35 weight portions, Folium Ginseng 45 weight portion～50 weight portions, Resina Toxicodendri 10 weight portion～15 weight portions, Flos Lonicerae 20 weight portion～25 weight portions, Fructus Toosendan 25 weight portion～30 weight portions, Herba Portulacae 20 weight portion～25 weight portions, Cortex Acanthopancis 35 weight portion～40 weight portions, Spina Gleditsiae 20 weight portion～25 weight portions, Rabdosia rubescens 25 weight portion～30 weight portions, the Fructus Kochiae 20 weight portion～25 weight portions, Radix Rehmanniae Preparata 30 weight portion～35 weight portions, Cortex Phellodendri 20 weight portion～25 weight portions and Radix Glycyrrhizae 15 weight portion～20 weight portions.

In described Chinese medicine composition, the weight portion of each crude drug is further preferably respectively Radix Dichroae 35 weight portion～40 weight portions, Radix Et Rhizoma Rhei 70 weight portion～75 weight portions, Caulis Spatholobi 20 weight portion～25 weight portions, Rhizoma Polygonati 25 weight portion～30 weight portions, Radix seu Herba Gei aleppici 50 weight portion～55 weight portions, Radix Rubiae 15 weight portion～20 weight portions, Cortex Phellodendri 55 weight portion～60 weight portions, Ramulus Uncariae Cum Uncis 30 weight portion～35 weight portions, Herba Agrimoniae 20 weight portion～25 weight portions, Radix Pseudostellariae 30 weight portion～35 weight portions, Fructus Corni 25 weight portion～30 weight portions, Fructus Bruceae 30 weight portion～35 weight portions, Herba monochasmatis 30 weight portion～35 weight portions, Flos Trollii 20 weight portion～25 weight portions, Elephantopus scaber L. 35 weight portion～40 weight portions, Folium Ginseng 50 weight portion～55 weight portions, Resina Toxicodendri 15 weight portion～20 weight portions, Flos Lonicerae 25 weight portion～30 weight portions, Fructus Toosendan 30 weight portion～35 weight portions, Herba Portulacae 25 weight portion～30 weight portions, Cortex Acanthopancis 40 weight portion～45 weight portions, Spina Gleditsiae 25 weight portion～30 weight portions, Rabdosia rubescens 30 weight portion～35 weight portions, the Fructus Kochiae 25 weight portion～30 weight portions, Radix Rehmanniae Preparata 35 weight portion～40 weight portions, Cortex Phellodendri 25 weight portion～30 weight portions and Radix Glycyrrhizae 20 weight portion～25 weight portions.

In described Chinese medicine composition, the weight portion of each crude drug is most preferably respectively Radix Dichroae 40 weight portions, Radix Et Rhizoma Rhei 75 weight portions, Caulis Spatholobi 25 weight portions, Rhizoma Polygonati 30 weight portions, Radix seu Herba Gei aleppici 55 weight portions, Radix Rubiae 20 weight portions, Cortex Phellodendri 60 weight portions, Ramulus Uncariae Cum Uncis 35 weight portions, Herba Agrimoniae 25 weight portions, Radix Pseudostellariae 35 weight portions, Fructus Corni 30 weight portions, Fructus Bruceae 35 weight portions, Herba monochasmatis 35 weight portions, Flos Trollii 25 weight portions, Elephantopus scaber L. 35 weight portions, Folium Ginseng 50 weight portions, Resina Toxicodendri 15 weight portions, Flos Lonicerae 25 weight portions, Fructus Toosendan 30 weight portions, Herba Portulacae 25 weight portions, Cortex Acanthopancis 40 weight portions, Spina Gleditsiae 25 weight portions, Rabdosia rubescens 30 weight portions, the Fructus Kochiae 25 weight portions, Radix Rehmanniae Preparata 35 weight portions, Cortex Phellodendri 25 weight portions and Radix Glycyrrhizae 20 weight portions.

The Chinese medicine composition that is used for the treatment of chicken Eimeria Tenella disease provided by the invention can be prepared into powder and be mixed in feedstuff, also can be prepared into decoct.

Further, described feedstuff only consists of above-mentioned raw materials composition.

Radix Dichroae: latin name Dichroae Radix, bitter in the mouth, pungent, cold in nature, return lung, liver, heart channel, there is the effect of vomiting phlegm and saliva by emesis, cure mainly phlegm retention and stop gathering, the cards such as chest and diaphragm painful abdominal mass plug.

Radix Et Rhizoma Rhei: bitter in the mouth, cold in nature, return stomach warp; Large intestine channel; Liver Channel; Spleen channel, have attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; The effect of removing toxic substances, cures mainly excess-heat constipation; The accumulation of heat feeling of stuffiness in chest; Damp-heat dysentery; Jaundice; Gonorrhea; Edema abdominal distention; Dysuria; Conjunctival congestion; Laryngopharynx swelling and pain; Aphtha of the mouth and tongue; Gastropyretic vomiting; Spit blood; Spitting of blood; Epistaxis; Have blood in stool; Hematuria; Blood-retention; Amenorrhea; The stagnant stomachache of the stasis of blood in puerperal; Lump in the abdomen; Traumatic injury; Pyretic toxicity carbuncle and ulcer; Erysipelas; The cards such as scald, Radix Et Rhizoma Rhei hemostatic mechanism is that rhatannin can be restrained wound surface and stop blooding, can lower the permeability of blood capillary and improve its fragility, reduce the outflow of wound surface body fluid, having increases platelet, makes blood clotting time shorten, promotes the effect of blood coagulation, and Radix et Rhizoma Rhei (stir-fried with wine) is for Akamu pharyngeal swelling, gingivitis, Radix Et Rhizoma Rhei is got the property of its bitter cold sedimentation, and main purgation of spleen excess excess of the stomach fire and high Sheng be fire mutually, can make the fiery of inflammation following let out.

Caulis Spatholobi: bitter in the mouth, sweet, warm in nature, enter liver, kidney channel, there is blood vessel dilating, enrich blood and invigorate blood circulation, regulating menstruation, the effect of relaxing muscles and tendons and activating QI and blood in the collateral, has obvious inhibitory action to platelet aggregation, promote animal kidney and the total phosphorus metabolism in uterus, be mainly used in treating the menoxenia that blood deficiency has silt, limbs pain is meciless, the symptoms such as soreness of the waist and knees, pain.

Rhizoma Polygonati: sweet in the mouth, property is flat, enters lung, spleen, kidney channel, has the yin nourishing of fostering the spirit of nobility, spleen invigorating lung moistening, the effect of enriching kidney essence, for taste deficiency of qi and yin, lack of appetite is unable, lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, the quenching one's thirst of yin asthenia generating intrinsic heat, the cards such as deficiency of kidney essence, impotence and seminal emission, dizziness and tinnitus, blurred vision dim eyesight.

Radix seu Herba Gei aleppici: latin name Gei Herba, acrid in the mouth, hardship, property is flat, returns liver, spleen, lung meridian, has analgesia, blood pressure lowering, regulating menstruation, the effect of expelling wind and removing dampness, cures mainly hypertension, dizziness headache, menoxenia, lower abdominal pain, leucorrhea, infantile convulsion, lumbago, skelalgia of rheumatism; Carbuncle furuncle and phyma poison, the cards such as traumatic injury are controlled in external.

Radix Rubiae: cold in nature, bitter in the mouth, returns Liver Channel, effect: cooling blood for hemostasis; Blood circulation promoting and blood stasis dispelling, cards such as curing mainly heat in blood spitting of blood, haematemesis, epistaxis, hematuria, have blood in stool, metrorrhagia, amenorrhea, postpartum stagnation stomachache, traumatic injury, rheumatic arthralgia, jaundice, carbuncle sore, hemorrhoid are swollen.

Cortex Phellodendri: latin name Phellodendri Chinensis Cortex, bitter in the mouth, cold in nature, enter kidney, bladder, large intestine channel, heat clearing and damp drying, eliminating fire and detoxication, except hectic fever due to YIN-deficiency clearind deficient heat.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, the cards such as eczema pruritus.

Ramulus Uncariae Cum Uncis: sweet in the mouth, slightly warm in nature, enters Liver Channel, has the effect of heat clearing away, suppressing the hyperactive liver and subsiding YANG, relieving spasm by subduing liver-wind, is mainly used in the spasm due to the anxious raw wind of heat or liver-wind stirring up internally, twitch, restlessness, excessive rising of liver-YANG or Liver Channel have the headache of heat dizzy, the symptoms such as conjunctival congestion and swelling pain.

Herba Agrimoniae: latin name Agrimoniae Herba, bitter in the mouth, puckery, property is flat, GUIXIN, Liver Channel, have astringing to arrest bleeding, the effect of dysentery relieving parasite killing, cures mainly various hemorrhage cards, for example: haematemesis, hematuria, have blood in stool, metrorrhagia, spitting of blood, epistaxis, dysentery, impairment caused by overstrain takes off power, carbuncle, traumatic injury, the cards such as wound hemorrhage.

Radix Pseudostellariae: sweet in the mouth, micro-hardship, property is put down, and enters spleen, lung meridian, has air making-up and spleen enlivening, the effect of the lung moistening and production of body fluid promoting, for the lack of appetite asthenia of deficiency-weakness of spleen-QI, deficiency of stomach-Yin, energy strengthening the spleen gas, nourishing stomach-YIN, the deficiency of the lung cough caused by dryness of hindering for deficiency of vital energy Tianjin and cardiopalmus sleeplessness, deficiency-heat hyperhidrosis, energy supplementing QI for promoting the production of body fluid, controls deficiency of vital energy xeropulmonary cough, the cards such as the cardiopalmus sleeplessness of deficiency of both QI and YIN, hyperhidrosis.

Fructus Corni: sour in the mouth, puckery, slightly warm in nature, enters liver, kidney channel, has the admittedly de-effect of liver and kidney tonifying, arresting seminal emission, arresting sweating, cures mainly soreness of the waist and knees, the dizziness and tinnitus of the hepatic and renal YIN deficiency, excessive rising of liver-YANG, sexual impotence, essence is closed the cards such as not solid seminal emission, spermatorrhea, metrostaxis.

Fructus Bruceae: latin name Bruceae Fructus, bitter in the mouth, cold in nature, return large intestine channel, Liver Channel, there is heat-clearing and toxic substances removing, dysentery relieving, preventing the attack (or recurrence) of malaria, the effect of corrosion wart, cures mainly dysentery, malaria; The cards such as external treatment wart, clavus.

Herba monochasmatis: bitter in the mouth, cool in nature, for cough, spit blood, bloody dysentery, leukorrhagia, gingivitis, mastitis, furuncle and phyma.

Flos Trollii: latin name Trollius chinensis, bitter in the mouth, cool in nature, there is the effect of heat-clearing and toxic substances removing, cure mainly acute and chronic tonsillitis, acute otitis media, acute myringitis, acute conjunctivitis, the cards such as acute lymphangitis.

Elephantopus scaber L.: cold in nature, bitter in the mouth is pungent, has heat-clearing and toxic substances removing, the effect of inducing diuresis to remove edema, cures mainly flu, acute tonsillitis, pharyngolaryngitis, eye conjunctivitis, epidemic encephalitis type B, pertussis, acute icterohepatitis, cirrhotic ascites, acute and chronic nephritis, furuncle and phyma, the cards such as eczema.

Folium Ginseng: bitter in the mouth, sweet, cold in nature, attach to the lung and stomach meridians, there is QI invigorating, lung benefiting, drives away summer heat, and the effect of promoting the production of body fluid, cures mainly qi-asthenia cough, and summer-heat is irritated, and Tianjin wound is thirsty, and the head is unclear, the tired weary card that waits of extremity.

Resina Toxicodendri: latin name Toxicodendri Resina, acrid in the mouth, warm in nature, return liver, spleen channel, there is dissipating blood stasis to promote menstruationg, the effect of eliminating stagnated food and killing intestinal worms, for blood stasis amenorrhea, the cards such as abdominal pain due to worm stagnation.

Flos Lonicerae: latin name Loncerae Flos, sweet in the mouth, cold in nature, return lung, the heart, stomach warp, there is the effect of heat-clearing and toxic substances removing, dispelling wind and heat pathogens, cure mainly carbuncle furuncle, sore throat, red heat, toxic-heat and blood stasis, anemopyretic cold, the cards such as epidemic febrile disease.

Fructus Toosendan: bitter in the mouth, cold in nature, return liver, small intestinal, urinary bladder channel, have soothing the liverly expel the heat-evil, the effect of promoting the circulation of QI to relieve pain, cure mainly pathogenic fire derived from stagnation of liver-QI, the breast side of body, play the cards such as abdominal distention and pain, hernia pain, abdominal pain due to worm stagnation.

Herba Portulacae: latin name Portulacae herba, sour in the mouth, cold in nature, return large intestine, Liver Channel, has heat-clearing and toxic substances removing, diuretic dries, loose blood detumescence, and dust-collection sterilization, anti-inflammatory analgetic, the effect of hemostasis removing heat from blood, cures mainly dysentery, enteritis, nephritis, puerperal, metrorrhagia, had blood in stool, the diseases such as mastitis.

Cortex Acanthopancis: acrid in the mouth, hardship, micro-sweet, warm in nature, enter liver, kidney channel, there is wind-damp dispelling, invigorating the liver and kidney, the effect of bone and muscle strengthening, is mainly used in rheumatism and arthritis, and muscles and bones flaccidity is soft, traumatic injury, fracture, edema, the fragile card that waits, has gonadotropic Effect, can promote sexual accessory gland to grow.

Spina Gleditsiae: acrid in the mouth, warm in nature, return lung meridian, cure mainly swollen ulcer drug, scrofula, skin ulcer rash stubborn dermatitis, puerperal hypogalactia, placenta retention, the cards such as leprosy.

Rabdosia rubescens: bitter in the mouth, sweet, cold nature, returns lung, stomach, Liver Channel, has heat-clearing and toxic substances removing, and the effect of promoting blood circulation and stopping pain cures mainly the cards such as laryngopharynx swelling and pain, tonsillitis, headache due to common cold, tracheitis, chronic hepatitis, joint rheumatalgia, snake bite and insect sting.

The Fructus Kochiae: latin name KochiaeFructus, cold in nature, acrid in the mouth, hardship, enter kidney, urinary bladder channel, has clearing away heat-damp and promoting diuresis, and the effect of dispelling wind for relieving itching cures mainly the cards such as difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.

Radix Rehmanniae Preparata: have another name called Radix Rehmanniae Preparata, sweet in the mouth, slightly warm in nature, enters liver, kidney channel, has the YIN nourishing of enriching blood, and beneficial essence is filled out the effect of marrow, for blood deficiency and yellow complexion; Dizzy, cardiopalmus, insomnia, menoxenia, collapses more than; Hepatic and renal YIN deficiency, night sweat, sufficient knee joint pain, soreness of the waist and knees, Hiccough and deaf, the head is dim-sighted; Seminal emission sexual impotence; Infertility; Menoxenia; Metrostaxis; Early whitening of beard and hair; Quench one's thirst; Constipation; The cards such as dyspnea with rapid and short breath of suffering from a deficiency of the kidney, medicineization justice > > has cloud: Radix Rehmanniae Preparata, mat wine cooks, and bitter in the mouthization is sweet, alternating temperature cool in nature, special messenger's liver is enriched blood.Bitter anxious because of liver, with sweet, delay it, the main temperature gallbladder of holding concurrently, can beneficial painstaking effort, more the kidney invigorating water.All internal injuries are not enough, and bitter will is a tax on one's mind, and suffering wound is clamored, the consumption of indulging in sensual pleasures essence, and regulating menstruation tire produces, and all should use this.Settling five organs, and blood vessels, profit skin, the punching of nourishing heart, peaceful soul, nourish Kidney-Yin, packing bone marrow, for panacea also, get its abnormal smells from the patient dense, be turbid product in turbid, to mend, stare at kidney, therefore all raw Radix Rehmanniaes Preparata are coveted.Radix Rehmanniae Preparata can promote anemia animal erythrocyte, hemoglobin to recover, and accelerates the propagation of hematopoietic stem cell, bone marrow hemopoietic progenitor cell of red blood cell line, differentiation.

Cortex Phellodendri: latin name Phellodendri Amurensis Cortex, cold in nature, bitter in the mouth, return kidney, urinary bladder channel, have heat clearing and damp drying, pathogenic fire purging is except steaming, the effect of detoxification sore treatment, cures mainly the cards such as damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin.

Radix Glycyrrhizae: sweet in the mouth, property is flat, enters 12 warps, has heat-clearing and toxic substances removing, is in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and in, relieving spasm to stop pain, is mainly used in invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong, neutralizes by adding Radix Glycyrrhizae can play QI invigorating, is in harmonious proportion the effect of each component.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.

Embodiment 1 decocting liquid 1

By Radix Dichroae 40g, Radix Et Rhizoma Rhei 75g, Caulis Spatholobi 25g, Rhizoma Polygonati 30g, Radix seu Herba Gei aleppici 55g, Radix Rubiae 20g, Cortex Phellodendri 60g, Ramulus Uncariae Cum Uncis 35g, Herba Agrimoniae 25g, Radix Pseudostellariae 35g, Fructus Corni 30g, Fructus Bruceae 35g, Herba monochasmatis 35g, Flos Trollii 25g, Elephantopus scaber L. 35g, Folium Ginseng 50g, Resina Toxicodendri 15g, Flos Lonicerae 25g, Fructus Toosendan 30g, Herba Portulacae 25g, Cortex Acanthopancis 40g, Spina Gleditsiae 25g, Rabdosia rubescens 30g, Fructus Kochiae 25g, Radix Rehmanniae Preparata 35g, Cortex Phellodendri 25g and Radix Glycyrrhizae 20g mix, the water that adds 8kg, after soaking 1h, decoct, after intense fire is heated to seethe with excitement, slow fire maintains 2h, subsequent filtration, filtering residue adds the water of 5.5kg again, after soaking 1h, decoct, after intense fire is heated to seethe with excitement, slow fire maintains 2h, subsequent filtration, twice filtrate merges, medicinal liquid is concentrated into the decoct 1 that crude drug concentration is 1g/ml.

Embodiment 2 toxicological experiments

Acute toxicity testing

Select 20 of Kunming mouses, female half and half, body weight (20+2) g, is provided by Qingdao City's Experimental Animal Center, and the decoction liquor of embodiment 1 preparation is gavaged to mice, through preliminary experiment, fails to detect the LD of oral administration ₅₀therefore, survey its maximum tolerated dose, with the administration volume of 2.0ml/10g body weight, gavage 2 times/d, interval 6h, gives observation post administration 7d, record animal dead and toxicity symptom, when experiment finishes, all animals is processed, dissect, each main organs lesion tissue situation of perusal, gavages for 2 times after 140g crude drug/kg, animal activity, feed water inlet does not show any abnormalities, and observes 7d animal dead, and gross necropsy has no the obviously abnormal of main organs tissue.

Long term toxicity test

Select 40 male SD rats, weight (180 ± 20) g, by Qingdao City's Experimental Animal Center, provided, be divided at random 2 groups, blank group and Chinese drug-treated group, every group 20, blank group gives distilled water, Chinese drug-treated group, by the decoct 1 of embodiment 1 preparation, gavages rat, and the amount of gavaging is 50g crude drug/kg, on every Mondays to gastric infusion 1 time in morning Saturday, continuous 180d, administration volume is 2mL/100g body weight, observe rat general state, sign, food ration, drinking-water and feces situation every day before administration and during administration.During administration 90d, after last administration 24h, each group extracts 6, male and female half and half; During 180d, after last administration 24h, each group extracts 6, male and female half and half; After drug withdrawal, each group of 30d extracts 6, male and female half and half, with urethane, anaesthetize, from abdominal aortic, get blood, each group is all killed and is got animal, checks hematology and blood parameters, gets after blood, amass wealth by heavy taxation at once core, the internal organs such as liver,kidney,spleen, lung, adrenal gland, thyroid, thymus, testis, ovary, uterus, brain, prostate weigh, according to weight calculator official weight coefficient and make pathological examination.

On inspection, during successive administration, the activity of animal, body weight, food ration, stool and hair luster degree no abnormality seen, it is dead that animal has no, naked eyes have no obvious pathological changes, each organizes the inspection of rat peripheral hemogram all in normal range, and the raw tea index of blood is all in normal range, and Chinese drug-treated group Rats Organs and Tissues coefficient is compared and be there is no significant difference with blank group.

Embodiment 3 decocts 2

By Radix Dichroae 35g, Radix Et Rhizoma Rhei 70g, Caulis Spatholobi 20g, Rhizoma Polygonati 25g, Radix seu Herba Gei aleppici 50g, Radix Rubiae 15g, Cortex Phellodendri 55g, Ramulus Uncariae Cum Uncis 30g, Herba Agrimoniae 20g, Radix Pseudostellariae 30g, Fructus Corni 25g, Fructus Bruceae 30g, Herba monochasmatis 30g, Flos Trollii 20g, Elephantopus scaber L. 40g, Folium Ginseng 55g, Resina Toxicodendri 20g, Flos Lonicerae 30g, Fructus Toosendan 35g, Herba Portulacae 25 weight portions～30g, Cortex Acanthopancis 45g, Spina Gleditsiae 30g, Rabdosia rubescens 35g, Fructus Kochiae 2530g, Radix Rehmanniae Preparata 40g, Cortex Phellodendri 30g and Radix Glycyrrhizae 25g mix, the water that adds 8kg, after soaking 1h, decoct, after intense fire is heated to seethe with excitement, slow fire maintains 2h, subsequent filtration, filtering residue adds the water of 5.5kg again, after soaking 1h, decoct, after intense fire is heated to seethe with excitement, slow fire maintains 2h, subsequent filtration, twice filtrate merges, medicinal liquid is concentrated into the decoct 1 that crude drug concentration is 1g/ml.

Embodiment 4 powders 1

By Radix Dichroae 40g, Radix Et Rhizoma Rhei 75g, Radix seu Herba Gei aleppici 55g, Radix Pseudostellariae 35g, Fructus Bruceae 35g, Flos Trollii 25g, Cortex Acanthopancis 40g, Spina Gleditsiae 25g, Radix Rehmanniae Preparata 35g and Cortex Phellodendri 25g mix, and put into pressure vessel, add the Chinese liquor of 45 degree 50 degree of 1.6kg, and at room temperature, under the condition that pressure is 300MPa, pressurize 3 minutes, after release, filters, and collects filtrate, by Caulis Spatholobi 25g, Rhizoma Polygonati 30g, Radix Rubiae 20g, Cortex Phellodendri 60g, Ramulus Uncariae Cum Uncis 35g, Herba Agrimoniae 25g, Fructus Corni 30g, Herba monochasmatis 35g, Elephantopus scaber L. 35g, Folium Ginseng 50g, Resina Toxicodendri 15g, Flos Lonicerae 25g, Fructus Toosendan 30g, Herba Portulacae 25g, Rabdosia rubescens 30g, Fructus Kochiae 25g and Radix Glycyrrhizae 20g mix, and further mix with filtering residue above, add the water with respect to 4.5kg, after soaking 1h, decoct, after intense fire is heated to seethe with excitement, slow fire maintains 2h, subsequent filtration, filtering residue adds the water of 2kg again, after immersion 1h, decocts, and after intense fire is heated to seethe with excitement, slow fire maintains 2h, subsequent filtration, twice filtrate merges, and mixes with the filtrate of collecting above, concentrated except desolventizing, obtain mastic, pulverize, dry, cross 50 mesh sieves, obtain powder 1.

Embodiment 5 toxicological experiments

Acute toxicity testing

Select 20 of Kunming mouses, female half and half, body weight (20+2) g, by Qingdao City's Experimental Animal Center, provided, the powder 1 of embodiment 4 preparations is dissolved in distilled water, be prepared into the solution of 1g/ml, gavage mice, through preliminary experiment, fail to detect the LD of oral administration ₅₀therefore, survey its maximum tolerated dose, with the administration volume of 2.0ml/10g body weight, gavage 2 times/d, interval 6h, gives observation post administration 7d, record animal dead and toxicity symptom, when experiment finishes, all animals is processed, dissect, each main organs lesion tissue situation of perusal, gavages for 2 times after 140g crude drug/kg, animal activity, feed water inlet does not show any abnormalities, and observes 7d animal dead, and gross necropsy has no the obviously abnormal of main organs tissue.

Long term toxicity test

Select 40 male SD rats, weight (180 ± 20) g, by Qingdao City's Experimental Animal Center, provided, be divided at random 2 groups, blank group and Chinese drug-treated group, every group 20, blank group gives distilled water, Chinese drug-treated group is dissolved in the powder 1 of embodiment 4 preparations in distilled water, be prepared into the solution of 1g/ml, gavage rat, the amount of gavaging is 50g crude drug/kg, on every Mondays to gastric infusion 1 time in morning Saturday, continuous 180d, administration volume is 2mL/100g body weight, observe rat general state every day before administration and during administration, sign, food ration, drinking-water and feces situation.During administration 90d, after last administration 24h, each group extracts 6, male and female half and half; During 180d, after last administration 24h, each group extracts 6, male and female half and half; After drug withdrawal, each group of 30d extracts 6, male and female half and half, with urethane, anaesthetize, from abdominal aortic, get blood, each group is all killed and is got animal, checks hematology and blood parameters, gets after blood, amass wealth by heavy taxation at once core, the internal organs such as liver,kidney,spleen, lung, adrenal gland, thyroid, thymus, testis, ovary, uterus, brain, prostate weigh, according to weight calculator official weight coefficient and make pathological examination.

Embodiment 6 powders 2

By Radix Dichroae 45g, Radix Et Rhizoma Rhei 80g, Radix seu Herba Gei aleppici 60g, Radix Pseudostellariae 40g, Fructus Bruceae 40g, Flos Trollii 30g, Cortex Acanthopancis 35g, Spina Gleditsiae 20g, Radix Rehmanniae Preparata 30g and Cortex Phellodendri 20g mix, and put into pressure vessel, add the Chinese liquor of 45 degree 50 degree of 1.6kg, and at room temperature, under the condition that pressure is 300MPa, pressurize 3 minutes, after release, filters, and collects filtrate, by Caulis Spatholobi 20g, Rhizoma Polygonati 35g, Radix Rubiae 25g, Cortex Phellodendri 65g, Ramulus Uncariae Cum Uncis 40g, Herba Agrimoniae 30g, Fructus Corni 35g, Herba monochasmatis 40g, Elephantopus scaber L. 30g, Folium Ginseng 45g, Resina Toxicodendri 10g, Flos Lonicerae 20g, Fructus Toosendan 25g, Herba Portulacae 20g, Rabdosia rubescens 25g, Fructus Kochiae 20g and Radix Glycyrrhizae 15g mix, and further mix with filtering residue above, add the water with respect to 4.5kg, after soaking 1h, decoct, after intense fire is heated to seethe with excitement, slow fire maintains 2h, subsequent filtration, filtering residue adds the water of 2kg again, after immersion 1h, decocts, and after intense fire is heated to seethe with excitement, slow fire maintains 2h, subsequent filtration, twice filtrate merges, and mixes with the filtrate of collecting above, concentrated except desolventizing, obtain mastic, pulverize, dry, cross 50 mesh sieves, obtain powder 2.

Embodiment 7 feedstuffs 1

By Semen Maydis 500g, Semen Tritici aestivi 150g, Zein powder 25g, Oleum Glycines 20g, calcium hydrogen phosphate 12g, lysine 2g, methionine 0.8g, serine 0.8g, zinc methionine 0.4g, ferrous fumarate 0.2g, choline chloride 1g, 0.4g vitamin A, 0.6g vitamin E, 0.8g vitamin C, the powder 1 of 8g embodiment 4 preparations is grouped together, putting into multiplex mixer stirs 150 minutes, after taking-up, put into ring mode pulverizer and be ground into powder, then take out and put into dehydrator, the aridity of controlling dried material is 80%, the time of smoking is 70 minutes, putting into after removal and cooling multiplex mixer stirs 190 minutes, after taking-up, put into ring mode bulking machine expanded, control the temperature of bulking machine between 75 ℃, the expanded time is 2 hours, the aridity of controlling material to be extruded is 90%, after taking-up, proceed in ring mode grit machine and be produced into and precipitate hard particles feedstuff, then by 40 meshes, sieve.

Embodiment 8 zooperies

Experimental agents: diclazuril, Jiangsu animal drug factory produces; The decoct 1 of the embodiment of the present invention 1 preparation, the feedstuff 1 of embodiment 7 preparations.

Laboratory animal: provide totally 1000 of the assorted chickens of the healthy meat of 30 ages in days by certain body raiser of Qingdao City.Do not infect after testing coccidiosis, do not use any coccidiosis chemoprophylaxis and treatment yet.

Test worm strain: Eimeria tenella egg capsule is provided by Qingdao Agricultural University's animal medicine laboratory, is the purebred Eimeria egg capsule liquid of 16.8 ten thousand/m l of egg capsule concentration.

Grouping and treatment:

800 chickens are divided into 5 groups at random, 200 every group, are respectively: first infects administration group, will inoculate 100,000 Eimeria tenella egg capsules, occurs after symptom, gavages the decoct 1 of the embodiment of the present invention 1 preparation, and every day, the amount of gavaging was 50ml; Second infects administration group, will inoculate 100,000 Eimeria tenella egg capsules, occurs after symptom the feedstuff 1 of the feeding embodiment of the present invention 7 preparations; The 3rd infects administration group, will inoculate 100,000 Eimeria tenella egg capsules, occur after symptom, every day feeding 1mg/kg diclazuril; Infect not administration group, will inoculate 100,000 Eimeria tenella egg capsules, occur after symptom not administration; Matched group, does not infect egg capsule, need not any Drug therapy yet.

The preparation of egg capsule: getting concentration is the egg capsule liquid 125m l of 16.8 ten thousand/m l, and water decile is diluted to 2 parts, is placed in CEN-TR IFU GETDL-5 type centrifuge, centrifugal 3 times of 3000r/min, each 10min.Centrifugal rear abandoning supernatant, takes out the homogeneous solution that lower floor's egg capsule is made into 210m l, and egg capsule liquid concentration is now 100,000/m l.

Inoculation egg capsule liquid: chicken gavages 1.0ml egg capsule liquid (100,000 egg capsules) to crop with syringe.Feeding and management method is raised routinely, the raising situation of timing every day viewing test chicken and incidence etc.

Therapeutic evaluation:

Feces is scored: with reference to the standard of Morehouse (1970), the 4d after artificial challenge starts to observe blood stool situation, scores, and make full cell mean by every chicken, normal feces note 0 minute, on average there is how much piling feces and just remember how many minutes respectively in every chicken every day.

Lesion score: with reference to the standard of (1970) such as John son, cut open all test chickens of inspection, according to the order of severity of cuing open pathological changes in inspection rear intestinal, score, without pathological changes, remember 0 minute, Minimal change note 1 minute, caecum wall thickening has little medium hemorrhage note 2 minutes of arriving, and inside has a lot of clots notes 3 minutes, because coccidium infection is dead, remembers 4 minutes.And make full cell mean.

Pathological changes value: with reference to the standard of M erck Sharp, i.e. lesion score average * 10 of every group of chicken.

Egg capsule numeration: after infecting egg capsule the 5th, 6, in the feces of 7d excretion, each group is divided respectively multiple spot selected part hemafecia and fresh normal feces 1g typically, takes 1g after 7d mixes again.Add 9m l normal saline, being placed in mortar grinds gently, after becoming homogeneous solution, get 1ml and add saturated saline solution 8ml, be placed in 10ml test tube, then vibration shake up, with glue head dropper, draw appropriate homogeneous solution topping up in M cM aster enumerator, after being full of counting chamber, be placed in the micro-Microscopic observation counting of XS-212-201 physiology.First find first lattice in the counting chamber upper left corner to start counting, " S " type counting from top to bottom and from top to bottom, counts up to the worm's ovum number in 100 lattice of counting chamber.The worm's ovum number of 100 lattice is multiplied by 600 and is egg capsule counter value, according to said method counting is respectively organized egg sac number respectively.

Egg capsule index: egg capsule index=matched group or test group egg sac number/infect not administration group egg sac number * 100%.

Egg capsule value: the clear standard in reference angle field, egg capsule index is that 1% value of egg capsule when following is 0; In the time of 1%～25%, be designated as 5; 26%～50% is 10; In the time of 51%～75%, be 20; In the time of 76%～100%, be 40.

Weightening finish percentage rate: average weight gain/matched group group average weight gain * 100% of rate of body weight gain=each infected group.

Anticoccidial index (ACI): adopt the standard of Merck & Co., Inc., that is: anticoccidial index=(weightening finish percentage rate+survival rate)-(pathological changes value+egg capsule value).ACI≤120 are invalid, and ACI=120～160 are medium effective, and ACI=160～180 are good, and ACI>180 is outstanding.

Result:

Death condition after inoculation coccidian oocyst: after inoculation coccidian oocyst, death condition is in Table 1.First infects administration group, after inoculation egg capsule, 4d starts dead 16, after medication, 2d is dead 8,3d dead 2, dead 26 altogether, second infects administration group 4d after inoculation egg capsule starts dead 19, and after medication, 2d is dead 7, dead 3 of 3d, dead 29 altogether, the 3rd infects administration group 4d after inoculation egg capsule starts dead 16, and after medication, 2d is dead 12, dead 7 of 3d, dead 4 of 4d, dead 39 altogether, infect dead 133 altogether of not administration groups, there is not death in matched group.

After table 1 inoculation coccidian oocyst, respectively organize chicken death situation

Group	Chicken number (only)	Death toll (only)	Mortality rate (%)
				First infects administration group	200	26	13
Second infects administration group	200	29	14.5
				The 3rd infects administration group	200	39	19.5
Infect not administration group	200	133	66.5
				Matched group	200	0	0

Feces is scored: the first infection administration group and second infects administration group 4d chicken from inoculation egg capsule and starts to occur hemafecia, and 5d starts administration, and 6d hemafecia obviously reduces, and 5d hemafecia is the most serious, and it is the most serious to infect not administration group 6d, and 7d starts to reduce.On average scoring in Table 2 of each group.

Anticoccidial index (ACI) first infects administration group and infects not administration group anticoccidial index with the second infection administration group pathological changes value and significantly improve (P<0.01) as can be seen from Table 2.

After table 2 inoculation coccidian oocyst, respectively organize just egg capsule numeration situation of chicken manure

Lesion score and pathological changes value: as can be seen from Table 3, the first infection administration group and the second infection administration group pathological changes value are all starkly lower than and infect not administration group.

Lesion score and the pathological changes value of chicken respectively organized in table 3 test

Body weight and the Gain weight of each test group chicken of table 4 off-test front and rear

All above-mentioned these intellectual properties of primary enforcement, do not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims

1. a Chinese medicine composition that is used for the treatment of chicken Eimeria Tenella disease, is characterized in that: the crude drug of described Chinese medicine composition comprises Radix Dichroae, Radix Et Rhizoma Rhei, Caulis Spatholobi, Rhizoma Polygonati, Radix seu Herba Gei aleppici, Radix Rubiae, Cortex Phellodendri, Ramulus Uncariae Cum Uncis, Herba Agrimoniae, Radix Pseudostellariae, Fructus Corni, Fructus Bruceae, Herba monochasmatis, Flos Trollii, Elephantopus scaber L., Folium Ginseng, Resina Toxicodendri, Flos Lonicerae, Fructus Toosendan, Herba Portulacae, Cortex Acanthopancis, Spina Gleditsiae, Rabdosia rubescens, the Fructus Kochiae, Radix Rehmanniae Preparata, Cortex Phellodendri and Radix Glycyrrhizae.

2. Chinese medicine composition as claimed in claim 1, is characterized in that: in described Chinese medicine composition, the weight portion of each crude drug is respectively Radix Dichroae 35 weight portion～45 weight portions, Radix Et Rhizoma Rhei 70 weight portion～80 weight portions, Caulis Spatholobi 20 weight portion～30 weight portions, Rhizoma Polygonati 25 weight portion～35 weight portions, Radix seu Herba Gei aleppici 50 weight portion～60 weight portions, Radix Rubiae 15 weight portion～25 weight portions, Cortex Phellodendri 55 weight portion～65 weight portions, Ramulus Uncariae Cum Uncis 30 weight portion～40 weight portions, Herba Agrimoniae 20 weight portion～30 weight portions, Radix Pseudostellariae 30 weight portion～40 weight portions, Fructus Corni 25 weight portion～35 weight portions, Fructus Bruceae 30 weight portion～40 weight portions, Herba monochasmatis 30 weight portion～40 weight portions, Flos Trollii 20 weight portion～30 weight portions, Elephantopus scaber L. 30 weight portion～40 weight portions, Folium Ginseng 45 weight portion～55 weight portions, Resina Toxicodendri 10 weight portion～20 weight portions, Flos Lonicerae 20 weight portion～30 weight portions, Fructus Toosendan 25 weight portion～35 weight portions, Herba Portulacae 20 weight portion～30 weight portions, Cortex Acanthopancis 35 weight portion～45 weight portions, Spina Gleditsiae 20 weight portion～30 weight portions, Rabdosia rubescens 25 weight portion～35 weight portions, the Fructus Kochiae 20 weight portion～30 weight portions, Radix Rehmanniae Preparata 30 weight portion～40 weight portions, Cortex Phellodendri 20 weight portion～30 weight portions and Radix Glycyrrhizae 15 weight portion～25 weight portions.

3. Chinese medicine composition as claimed in claim 1 or 2, is characterized in that: in described Chinese medicine composition, the weight portion of each crude drug is respectively Radix Dichroae 40 weight portion～45 weight portions, Radix Et Rhizoma Rhei 75 weight portion～80 weight portions, Caulis Spatholobi 25 weight portion～30 weight portions, Rhizoma Polygonati 30 weight portion～35 weight portions, Radix seu Herba Gei aleppici 55 weight portion～60 weight portions, Radix Rubiae 20 weight portion～25 weight portions, Cortex Phellodendri 60 weight portion～65 weight portions, Ramulus Uncariae Cum Uncis 35 weight portion～40 weight portions, Herba Agrimoniae 25 weight portion～30 weight portions, Radix Pseudostellariae 35 weight portion～40 weight portions, Fructus Corni 30 weight portion～35 weight portions, Fructus Bruceae 35 weight portion～40 weight portions, Herba monochasmatis 35 weight portion～40 weight portions, Flos Trollii 25 weight portion～30 weight portions, Elephantopus scaber L. 30 weight portion～35 weight portions, Folium Ginseng 45 weight portion～50 weight portions, Resina Toxicodendri 10 weight portion～15 weight portions, Flos Lonicerae 20 weight portion～25 weight portions, Fructus Toosendan 25 weight portion～30 weight portions, Herba Portulacae 20 weight portion～25 weight portions, Cortex Acanthopancis 35 weight portion～40 weight portions, Spina Gleditsiae 20 weight portion～25 weight portions, Rabdosia rubescens 25 weight portion～30 weight portions, the Fructus Kochiae 20 weight portion～25 weight portions, Radix Rehmanniae Preparata 30 weight portion～35 weight portions, Cortex Phellodendri 20 weight portion～25 weight portions and Radix Glycyrrhizae 15 weight portion～20 weight portions.

4. the Chinese medicine composition as described in claims 1 to 3, is characterized in that: in described Chinese medicine composition, the weight portion of each crude drug is respectively Radix Dichroae 35 weight portion～40 weight portions, Radix Et Rhizoma Rhei 70 weight portion～75 weight portions, Caulis Spatholobi 20 weight portion～25 weight portions, Rhizoma Polygonati 25 weight portion～30 weight portions, Radix seu Herba Gei aleppici 50 weight portion～55 weight portions, Radix Rubiae 15 weight portion～20 weight portions, Cortex Phellodendri 55 weight portion～60 weight portions, Ramulus Uncariae Cum Uncis 30 weight portion～35 weight portions, Herba Agrimoniae 20 weight portion～25 weight portions, Radix Pseudostellariae 30 weight portion～35 weight portions, Fructus Corni 25 weight portion～30 weight portions, Fructus Bruceae 30 weight portion～35 weight portions, Herba monochasmatis 30 weight portion～35 weight portions, Flos Trollii 20 weight portion～25 weight portions, Elephantopus scaber L. 35 weight portion～40 weight portions, Folium Ginseng 50 weight portion～55 weight portions, Resina Toxicodendri 15 weight portion～20 weight portions, Flos Lonicerae 25 weight portion～30 weight portions, Fructus Toosendan 30 weight portion～35 weight portions, Herba Portulacae 25 weight portion～30 weight portions, Cortex Acanthopancis 40 weight portion～45 weight portions, Spina Gleditsiae 25 weight portion～30 weight portions, Rabdosia rubescens 30 weight portion～35 weight portions, the Fructus Kochiae 25 weight portion～30 weight portions, Radix Rehmanniae Preparata 35 weight portion～40 weight portions, Cortex Phellodendri 25 weight portion～30 weight portions and Radix Glycyrrhizae 20 weight portion～25 weight portions.

5. the Chinese medicine composition as described in claim 1 to 4, it is characterized in that: in described Chinese medicine composition, the weight portion of each crude drug is respectively Radix Dichroae 40 weight portions, Radix Et Rhizoma Rhei 75 weight portions, Caulis Spatholobi 25 weight portions, Rhizoma Polygonati 30 weight portions, Radix seu Herba Gei aleppici 55 weight portions, Radix Rubiae 20 weight portions, Cortex Phellodendri 60 weight portions, Ramulus Uncariae Cum Uncis 35 weight portions, Herba Agrimoniae 25 weight portions, Radix Pseudostellariae 35 weight portions, Fructus Corni 30 weight portions, Fructus Bruceae 35 weight portions, Herba monochasmatis 35 weight portions, Flos Trollii 25 weight portions, Elephantopus scaber L. 35 weight portions, Folium Ginseng 50 weight portions, Resina Toxicodendri 15 weight portions, Flos Lonicerae 25 weight portions, Fructus Toosendan 30 weight portions, Herba Portulacae 25 weight portions, Cortex Acanthopancis 40 weight portions, Spina Gleditsiae 25 weight portions, Rabdosia rubescens 30 weight portions, the Fructus Kochiae 25 weight portions, Radix Rehmanniae Preparata 35 weight portions, Cortex Phellodendri 25 weight portions and Radix Glycyrrhizae 20 weight portions.

6. a Chinese medicine composition decoct, is characterized in that: the crude drug of described decoct comprises Radix Dichroae, Radix Et Rhizoma Rhei, Caulis Spatholobi, Rhizoma Polygonati, Radix seu Herba Gei aleppici, Radix Rubiae, Cortex Phellodendri, Ramulus Uncariae Cum Uncis, Herba Agrimoniae, Radix Pseudostellariae, Fructus Corni, Fructus Bruceae, Herba monochasmatis, Flos Trollii, Elephantopus scaber L., Folium Ginseng, Resina Toxicodendri, Flos Lonicerae, Fructus Toosendan, Herba Portulacae, Cortex Acanthopancis, Spina Gleditsiae, Rabdosia rubescens, the Fructus Kochiae, Radix Rehmanniae Preparata, Cortex Phellodendri and Radix Glycyrrhizae.

7. the preparation method of Chinese medicine composition decoct described in claim 6, it is characterized in that: each component of described Chinese medicine composition is mixed in proportion, add the water with respect to 8～10 times of crude drug quality sums, after soaking 30min～1h, decoct, after intense fire is heated to seethe with excitement, slow fire maintains 1h～2h, subsequent filtration, filtering residue adds the water with respect to 5～8 times of crude drug quality sums again, after soaking 30min～1h, decoct, after intense fire is heated to seethe with excitement, slow fire maintains 1h～2h, subsequent filtration, twice filtrate merges, and medicinal liquid is concentrated into the decoct that crude drug concentration is 1g/ml.

8. a Chinese medicine composition composition powders, is characterized in that: the crude drug of described powder comprises Radix Dichroae, Radix Et Rhizoma Rhei, Caulis Spatholobi, Rhizoma Polygonati, Radix seu Herba Gei aleppici, Radix Rubiae, Cortex Phellodendri, Ramulus Uncariae Cum Uncis, Herba Agrimoniae, Radix Pseudostellariae, Fructus Corni, Fructus Bruceae, Herba monochasmatis, Flos Trollii, Elephantopus scaber L., Folium Ginseng, Resina Toxicodendri, Flos Lonicerae, Fructus Toosendan, Herba Portulacae, Cortex Acanthopancis, Spina Gleditsiae, Rabdosia rubescens, the Fructus Kochiae, Radix Rehmanniae Preparata, Cortex Phellodendri and Radix Glycyrrhizae.

9. the preparation method of Chinese medicine composition composition powders described in claim 8, is characterized in that: described preparation method is specially,

10. a feedstuff, it comprises Semen Maydis 500～600 weight portions, Semen Tritici aestivi 120～210 weight portions, Zein powder 20～25 weight portions, Oleum Glycines 10～30 weight portions, calcium hydrogen phosphate 10～15 weight portions, lysine 1.9～3 weight portions, methionine 0.5～1 weight portion, serine 0.5～1 weight portion, zinc methionine 0.2～0.5 weight portion, ferrous fumarate 0.1～0.3 weight portion, choline chloride 0.8～1 weight portion, vitamin A 0.3～0.4 weight portion, vitamin E 0.5～0.8 weight portion, vitamin C 0.6～1.0 weight portion, said herbal medicine powder feed additive 5～9 weight portions.