CN103721147A - Traditional Chinese medicine composition for treating chicken coccidiosis - Google Patents
Traditional Chinese medicine composition for treating chicken coccidiosis Download PDFInfo
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Abstract
The invention provides traditional Chinese medicine composition for treating chicken coccidiosis. The traditional Chinese medicine composition comprises crude medicines such as artemisia apiacea, liquorice, ferula asafoetida, polygonum cuspidatum, dandelions, azedarach, prepared rehmannia roots, sargentgloryvine stems, purslane, radix bupleuri, selaginella tamariscina, cowherb seeds, astragalus membranaceus, magnolia officinalis, resurrection lily rhizome, acanthopanax roots, burdock, betel nuts, black sesame, mysore thorn roots, pungent litse fruits and ferns. The traditional Chinese medicine composition has the advantages that the composition is not prone to development of drug resistance, extremely small in toxic and side effects and capable of promoting the organism growth, enhancing the immunity, improving the disease resistance of organisms and the like and has a significant effect on treatment of the chicken coccidiosis.
Description
Technical field
The present invention relates to Chinese medicine technical field, relate in particular to a kind of Chinese medicine composition that is used for the treatment of chicken coccidiosis.
Background technology
Chicken coccidiosis (avian coccidiosis) is to parasitize caused a kind of parasitic protozoa disease in Intestinum Gallus domesticus tract epithelial cell by Eimeria (Eimeria) coccidiosis.Intensive chicken farm is the place of often breaking out coccidiosis, and its sickness rate reaches 60%～80%, and mortality rate is 20%～40%, when serious up to 80%.
Sick chicken is this sick source of infection, and the feedstuff being polluted by sick chicken, drinking-water, apparatus all have worm's ovum to exist.It is main route of transmission that chicken eats into infectious egg capsule, and fly, muroid are mechanical transmission medium.Chicken resistance declines, vitamin A, vitamin K deficiency in feedstuff, and malnutrition all can bring out this disease.
Suffer from chicken down in spirits, drowsiness, by Mao Songluan, close order drop-head, slow-wittedly vertically hang wing, like together crowded, crop speak in a low voice be full of liquid, the dysentery of having blood in stool, the adhesion of crissum feathers because manure contamination, happiness drink or go on a hunger strike, visual mucosa, hat, whisker are pale.Disease spiritedness symptom in latter stage, stupor, bipod turns up, stiff or spasm.
Since the forties in last century, sulfa drugs was used for raising chickens production, successively there are 30 multi-medicaments to drop into clinical practices, bring unprecedented development to modern poultry husbandry, can say there is no the Application and Development of coccidiostat, just there is no modern intensive poultry husbandry.But along with the extensive use of medicine, coccidiosis Drug resistance problem is increasingly general and serious, the business service life of medicine has been shortened in the generation of multi-drug resistance or cross-resistance greatly.Much research confirms, and chicken coccidiosis has almost all produced drug resistance to all used coccidiostats, thereby causes the shortening of anticoccidial drug service life, control failure or poor effect, causes clinical or subclinical chicken coccidiosis, causes very large economic loss.Chicken coccidiosis has cross resistance, when coccidiosis is during to certain anticoccidial drug deposits yields drug resistance, also can produce drug resistance to always not contacted medicine, and this drug resistance often comes across between the medicine that chemical constitution is similar, the mechanism of action is close.The generation of drug resistance is that in coccidiosis colony, mutated individual repeatedly repeats the result of selecting, and coccidiosis carries out sexual propagation in the later stage of its biocycle, forms egg capsule, and therefore drug resistance also passes on from generation to generation.
Conventional coccidiostat is a lot, when using coccidiostat, must consider the problem of two aspects: 1, effectively control coccidiosis, the loss that coccidiosis is caused is down to minimum; 2, postpone coccidiosis to anticoccidial drug deposits yields drug resistance used, the service life of prolong drug.For reaching previous object, not only to lean on efficient coccidiostat, and will make chicken produce gradually certain protective immunity to coccidiosis, so need to reasonably use coccidiostat.For postponing coccidiosis, produce drug resistance, way is regularly to convert or the different coccidiostat of the use in conjunction mechanism of action preferably, avoids excessively using any specific coccidiostat.Alternating mode between selection, treatment sequence and several program of coccidiostat depends on many factors, as the characteristic of various different coccidiostats, use history, the result of use in past; There is situation and certain medicine occurred to time of drug resistance etc. in the epidemiology of coccidiosis, drug-resistant worm plant.
Western medicine is expensive, medicine is easily produced to drug resistance to coccidiosis and medicine residual quantity in chicken product is large, affect people's health, and Chinese medicine has the generation of being difficult for drug resistance, toxic and side effects is minimum, there is promotion body growth, strengthen immunologic function, improve the advantages such as body resistance against diseases, therefore, adopt Chinese herbal treatment chicken coccidiosis more and more to become the focus that people pay close attention to, the present invention is exactly on the basis of theory of Chinese medical science, a kind of Chinese medicine composition that is used for the treatment of chicken coccidiosis is provided, it has Chinese medicine and has the generation of being difficult for drug resistance, toxic and side effects is minimum, there is promotion body growth, strengthen immunologic function, improve the advantages such as body resistance against diseases.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Chinese medicine composition that is used for the treatment of chicken coccidiosis, it has the generation of being difficult for drug resistance, toxic and side effects is minimum, there is promotion body growth, strengthen immunologic function, improve the advantages such as body resistance against diseases, aspect treatment chicken coccidiosis, there is significant effect.
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine composition that is used for the treatment of chicken coccidiosis, its crude drug comprises Herba Artemisiae Annuae, Radix Glycyrrhizae, Resina Ferulae, Rhizoma Polygoni Cuspidati, Herba Taraxaci, Cortex Meliae, Radix Rehmanniae Preparata, Caulis Sargentodoxae, Herba Portulacae, Radix Bupleuri, Herba Selaginellae, Semen Vaccariae, the Radix Astragali, Cortex Magnoliae Officinalis, Rhizoma Kaempferiae, Radix Et Caulis Acanthopanacis Senticosi, Fructus Arctii, Semen Arecae, Semen Sesami Nigrum, Radix Caesalpiniae Radicis, Fructus Litseae pungentis and Herba Fimbristylis dichotomae.
Wherein, in described Chinese medicine composition, the weight portion of each crude drug is respectively Herba Artemisiae Annuae 45 weight portion～55 weight portions, Radix Glycyrrhizae 25 weight portion～35 weight portions, Resina Ferulae 30 weight portion～40 weight portions, Rhizoma Polygoni Cuspidati 55 weight portion～65 weight portions, Herba Taraxaci 45 weight portion～55 weight portions, Cortex Meliae 45 weight portion～55 weight portions, Radix Rehmanniae Preparata 25 weight portion～35 weight portions, Caulis Sargentodoxae 30 weight portion～40 weight portions, Herba Portulacae 25 weight portion～35 weight portions, Radix Bupleuri 30 weight portion～40 weight portions, Herba Selaginellae 25 weight portion～35 weight portions, Semen Vaccariae 20 weight portion～30 weight portions, the Radix Astragali 50 weight portion～60 weight portions, Cortex Magnoliae Officinalis 30 weight portion～40 weight portions, Rhizoma Kaempferiae 25 weight portion～35 weight portions, Radix Et Caulis Acanthopanacis Senticosi 35 weight portion～45 weight portions, Fructus Arctii 20 weight portion～30 weight portions, Semen Arecae 25 weight portion～35 weight portions, Semen Sesami Nigrum 20 weight portion～30 weight portions, Radix Caesalpiniae Radicis 25 weight portion～35 weight portions, Fructus Litseae pungentis 35 weight portion～45 weight portions and Herba Fimbristylis dichotomae 45 weight portion～55 weight portions.
Wherein, in described Chinese medicine composition, the weight portion of each crude drug is respectively Herba Artemisiae Annuae 48 weight portion～52 weight portions, Radix Glycyrrhizae 28 weight portion～32 weight portions, Resina Ferulae 33 weight portion～37 weight portions, Rhizoma Polygoni Cuspidati 58 weight portion～62 weight portions, Herba Taraxaci 48 weight portion～52 weight portions, Cortex Meliae 48 weight portion～52 weight portions, Radix Rehmanniae Preparata 28 weight portion～32 weight portions, Caulis Sargentodoxae 33 weight portion～37 weight portions, Herba Portulacae 28 weight portion～32 weight portions, Radix Bupleuri 33 weight portion～37 weight portions, Herba Selaginellae 28 weight portion～32 weight portions, Semen Vaccariae 23 weight portion～27 weight portions, the Radix Astragali 53 weight portion～57 weight portions, Cortex Magnoliae Officinalis 33 weight portion～37 weight portions, Rhizoma Kaempferiae 28 weight portion～32 weight portions, Radix Et Caulis Acanthopanacis Senticosi 38 weight portion～42 weight portions, Fructus Arctii 23 weight portion～27 weight portions, Semen Arecae 28 weight portion～32 weight portions, Semen Sesami Nigrum 23 weight portion～27 weight portions, Radix Caesalpiniae Radicis 28 weight portion～32 weight portions, Fructus Litseae pungentis 38 weight portion～42 weight portions and Herba Fimbristylis dichotomae 48 weight portion～52 weight portions.
Wherein, in described Chinese medicine composition, the weight portion of each crude drug is respectively Herba Artemisiae Annuae 50 weight portions, Radix Glycyrrhizae 30 weight portions, Resina Ferulae 35 weight portions, Rhizoma Polygoni Cuspidati 60 weight portions, Herba Taraxaci 50 weight portions, Cortex Meliae 50 weight portions, Radix Rehmanniae Preparata 30 weight portions, Caulis Sargentodoxae 35 weight portions, Herba Portulacae 30 weight portions, Radix Bupleuri 35 weight portions, Herba Selaginellae 30 weight portions, Semen Vaccariae 25 weight portions, the Radix Astragali 55 weight portions, Cortex Magnoliae Officinalis 35 weight portions, Rhizoma Kaempferiae 30 weight portions, Radix Et Caulis Acanthopanacis Senticosi 40 weight portions, Fructus Arctii 25 weight portions, Semen Arecae 30 weight portions, Semen Sesami Nigrum 25 weight portions, Radix Caesalpiniae Radicis 30 weight portions, Fructus Litseae pungentis 40 weight portions and Herba Fimbristylis dichotomae 50 weight portions.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, is specially:
Above-mentioned raw materials medicine component is mixed by weight, obtain mixture, put into reactor, add the water with respect to 3～5 times of mixture qualities, slow fire heating decocts 2～4 hours, and decoction liquor is filtered, filtering residue adds the water with respect to 2～4 times of the mixture qualities obtaining above, slow fire boiling 1～3 hour again, and decoction liquor is filtered again, filtrate is merged, concentrated except anhydrating, obtain mastic, dry, pulverize, obtain Chinese medicine composition composition powders.
The present invention also provides a kind of Chinese medicine composition composition powders that is used for the treatment of chicken coccidiosis, and its crude drug comprises Herba Artemisiae Annuae, Radix Glycyrrhizae, Resina Ferulae, Rhizoma Polygoni Cuspidati, Herba Taraxaci, Cortex Meliae, Radix Rehmanniae Preparata, Caulis Sargentodoxae, Herba Portulacae, Radix Bupleuri, Herba Selaginellae, Semen Vaccariae, the Radix Astragali, Cortex Magnoliae Officinalis, Rhizoma Kaempferiae, Radix Et Caulis Acanthopanacis Senticosi, Fructus Arctii, Semen Arecae, Semen Sesami Nigrum, Radix Caesalpiniae Radicis, Fructus Litseae pungentis and Herba Fimbristylis dichotomae;
The preparation method of described Chinese medicine composition composition powders is specially mixes above-mentioned raw materials medicine component by weight, obtains mixture, puts into reactor, add the water with respect to 3～5 times of mixture qualities, slow fire heating decocts 2～4 hours, and decoction liquor is filtered, filtering residue adds the water with respect to 2～4 times of the mixture qualities obtaining above, slow fire boiling 1～3 hour again, and decoction liquor is filtered again, filtrate is merged, concentrated except anhydrating, obtain mastic, dry, pulverize, obtain Chinese medicine composition composition powders.
Wherein, in described Chinese medicine composition composition powders, the weight portion of each crude drug is respectively Herba Artemisiae Annuae 45 weight portion～55 weight portions, Radix Glycyrrhizae 25 weight portion～35 weight portions, Resina Ferulae 30 weight portion～40 weight portions, Rhizoma Polygoni Cuspidati 55 weight portion～65 weight portions, Herba Taraxaci 45 weight portion～55 weight portions, Cortex Meliae 45 weight portion～55 weight portions, Radix Rehmanniae Preparata 25 weight portion～35 weight portions, Caulis Sargentodoxae 30 weight portion～40 weight portions, Herba Portulacae 25 weight portion～35 weight portions, Radix Bupleuri 30 weight portion～40 weight portions, Herba Selaginellae 25 weight portion～35 weight portions, Semen Vaccariae 20 weight portion～30 weight portions, the Radix Astragali 50 weight portion～60 weight portions, Cortex Magnoliae Officinalis 30 weight portion～40 weight portions, Rhizoma Kaempferiae 25 weight portion～35 weight portions, Radix Et Caulis Acanthopanacis Senticosi 35 weight portion～45 weight portions, Fructus Arctii 20 weight portion～30 weight portions, Semen Arecae 25 weight portion～35 weight portions, Semen Sesami Nigrum 20 weight portion～30 weight portions, Radix Caesalpiniae Radicis 25 weight portion～35 weight portions, Fructus Litseae pungentis 35 weight portion～45 weight portions and Herba Fimbristylis dichotomae 45 weight portion～55 weight portions.
The present invention also provides a kind of feedstuff, and it comprises that feedstuff main body and above-mentioned Chinese medicine composition are as feed additive, and described Chinese medicine composition feed additive accounts for 10%～15% of feeding quality.
Beneficial effect of the present invention:
Chinese medicine composition provided by the invention has the generation of being difficult for drug resistance, and toxic and side effects is minimum, has promotion body growth, strengthens immunologic function, improves the advantages such as body resistance against diseases, aspect treatment chicken coccidiosis, has significant effect.
The specific embodiment
The invention provides a kind of Chinese medicine composition that is used for the treatment of chicken coccidiosis, its crude drug comprises Herba Artemisiae Annuae, Radix Glycyrrhizae, Resina Ferulae, Rhizoma Polygoni Cuspidati, Herba Taraxaci, Cortex Meliae, Radix Rehmanniae Preparata, Caulis Sargentodoxae, Herba Portulacae, Radix Bupleuri, Herba Selaginellae, Semen Vaccariae, the Radix Astragali, Cortex Magnoliae Officinalis, Rhizoma Kaempferiae, Radix Et Caulis Acanthopanacis Senticosi, Fructus Arctii, Semen Arecae, Semen Sesami Nigrum, Radix Caesalpiniae Radicis, Fructus Litseae pungentis and Herba Fimbristylis dichotomae.
Further preferably, described Chinese medicine composition only consists of above-mentioned raw materials medicine.
In side, Herba Artemisiae Annuae, Cortex Meliae, Semen Arecae sterilization, suppress coccidiosis expulsion exopathogen, Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription, Resina Ferulae, Cortex Magnoliae Officinalis, Rhizoma Kaempferiae appetite-stimulating indigestion-relieving, change stagnant removing food stagnancy, Rhizoma Polygoni Cuspidati, Herba Taraxaci bowel relieving dampness, gets rid of enterogenous endotoxin, Radix Rehmanniae Preparata, Caulis Sargentodoxae blood circulation promoting and enriching, Herba Portulacae stem and leaf has removing toxic substances, heat clearing away, the features such as detumescence, to escherichia coli, dysentery bacteriums etc. all have significant inhibitory action, and Radix Bupleuri has anti-infectious function, can suppress the increase of the vascular permeability that histamine or 5-hydroxy tryptamine cause, and can effectively eliminate or alleviate the inflammatory activity causing after coccidium infection chicken body, Herba Selaginellae, Semen Vaccariae can cooling blood for hemostasis, relieving diarrhea with astringents, can alleviate because of coccidiosis cause hemorrhage, dysentery, the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi replenishing QI to invigorate the spleen enhancing human body immunity power, Fructus Corni liver and kidney tonifying, enhancing body resistance, Fructus Arctii dispelling wind and heat pathogens, heat-clearing and toxic substances removing, Semen Sesami Nigrum invigorating the liver and kidney, benefiting essence-blood, intestine moistening is dry, Radix Caesalpiniae Radicis removing toxic substances and promoting subsidence of swelling, Fructus Litseae pungentis warming middle-JIAO to promote flow of QI, drying damp and strengthening spleen, Herba Fimbristylis dichotomae heat clearing away parasite killing.
Each crude drug pharmacology is specially:
Herba Artemisiae Annuae: latin name Artemisiae Annuae Herba, bitter in the mouth, pungent, cold in nature, return liver, gallbladder meridian, have deficiency-heat clearly thoroughly, removing heat from blood is except steaming, and except steaming, the effect of preventing the attack (or recurrence) of malaria, cures mainly pathogenic summer-heat heating, fever due to yin deficiency, night fever abating at dawn, hectic fever due to YIN-deficiency consumptive fever, malaria cold and heat, the cards such as jaundice due to damp-heat.
Radix Glycyrrhizae: sweet in the mouth, property is flat, returns 12 warps, has heat-clearing and toxic substances removing, is in harmonious proportion the property of medicine, the effect of expelling phlegm for arresting cough, and can spleen invigorating and in, relieving spasm to stop pain, is mainly used in the abdominal distension and anorexia of weakness of the spleen and stomach, weak; Can alleviate contracture pain in abdomen, relax the strong and toxicity of some drugs, alleviate the toxic and side effects of medicine to body or gastrointestinal is stimulated, by adding Radix Glycyrrhizae can play QI invigorating neutralization, be in harmonious proportion the effect of each component.
Resina Ferulae: bitter in the mouth, pungent, warm in nature, return kidney, stomach warp, there is removing food stagnancy, loose painful abdominal mass, the effect of parasite killing, for meat stagnation, blood stasis lump in the abdomen, mass in abdomen, the cards such as abdominal pain due to worm stagnation.
Rhizoma Polygoni Cuspidati: mildly bitter flavor, cold nature, return liver, gallbladder, lung meridian, there is the effect of expelling wind and removing dampness, dissipating blood stasis analgesic therapy, preventing phlegm from forming and stopping coughing, cure mainly arthralgia, jaundice due to damp-heat, amenorrhea ， WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, injury from falling down, the cards such as carbuncle sore tumefacting virus.
Herba Taraxaci: sweet in the mouth, hardship, cold in nature, enter liver, stomach warp, there is the effect of heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, liver heat removing and eyesight improving, inducing diuresis for treating stranguria syndrome, be mainly used in the treatment of sore swollen toxin, especially remarkable to acute mastitis effect, also can be used for the treatment of the symptoms such as the conjunctival congestion and swelling pain of flaming up of liver-fire, in addition, also there is the effect of promoting urination to remove dampness, for controlling the treatment of the diseases such as jaundice due to damp-heat, dysuria, urinary system infection.
Cortex Meliae: latin name Meliae Cortex, bitter in the mouth, cold in nature, return liver, spleen, stomach warp, there is parasite killing, treat tinea, for ascariasis, enterobiasis, the cards such as abdominal pain due to worm stagnation.
Radix Rehmanniae Preparata: sweet in the mouth, slightly warm in nature, enters liver, kidney channel, has the YIN nourishing of enriching blood, and beneficial essence is filled out the effect of marrow, for blood deficiency and yellow complexion; Dizzy, cardiopalmus, insomnia, menoxenia, collapses more than; Hepatic and renal YIN deficiency, night sweat, sufficient knee joint pain, soreness of the waist and knees, Hiccough and deaf, the head is dim-sighted; Seminal emission sexual impotence; Infertility; Menoxenia; Metrostaxis; Early whitening of beard and hair; Quench one's thirst; Constipation; The cards such as dyspnea with rapid and short breath of suffering from a deficiency of the kidney.
Caulis Sargentodoxae: bitter in the mouth, property is flat, returns liver, large intestine channel, has the eliminating carbuncle of relieving internal heat, promoting blood circulation to remove obstruction in the collateral, the effect of wind dispelling insecticide, cures mainly acute and chronic appendicitis, rheumatic arthralgia, bloody dysentery, stranguria with blood, menoxenia, infantile malnutrition, worm pain, the cards such as injury from falling down.
Herba Portulacae: latin name Portulacae herba, sour in the mouth, cold in nature, return large intestine, Liver Channel, has heat-clearing and toxic substances removing, diuretic dries, loose blood detumescence, and dust-collection sterilization, anti-inflammatory analgetic, the effect of hemostasis removing heat from blood, cures mainly dysentery, enteritis, nephritis, puerperal, metrorrhagia, had blood in stool, the cards such as mastitis.
Radix Bupleuri: bitter in the mouth, cold nature, returns liver, gallbladder meridian, has to evacuate to bring down a fever, and the effect of yang invigorating soothing liver-QI, cures mainly cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, the card such as uterus comes off, menoxenia.
Herba Selaginellae: acrid in the mouth, property is flat, returns liver, heart channel, has the effect of promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea ， WEIJIA mass in the abdomen, injury from falling down, to spit blood, metrorrhagia, has blood in stool, the cards such as proctoptosis.
Semen Vaccariae: bitter in the mouth, property is flat, enters liver, and stomach warp, has promoting blood circulation to restore menstrual flow, stimulating milk secretion eliminating carbuncle, the effect of inducing diuresis for treating stranguria syndrome, cures mainly blood stasis amenorrhea, dysmenorrhea, difficult labour; Lack of lactation after delivery, acute mastitis swells and ache; Pyretic stranguria, stranguria with blood, the cards such as stranguria caused by urinary stone.
The Radix Astragali: sweet in the mouth, warm in nature, return lung, spleen channel, there is tonification spleen soil, elevate a turnable ladder yang-energy, strengthening superficial resistance to stop perspiration, the effects such as holder skin ulcer granulation promoting, are mainly used in treating the weak anorexia and loose stool due to deficiency of both the splenic and pulmonary QI, shortness of breath and palpitation, the visceroptosis of sinking of QI of middle-JIAO, the metrorrhagia of QI failing to control blood is had blood in stool, chronic diarrhea proctoptosis; The spontaneous sweating of exterior deficiency; Insufficiency of vital energy and blood, yang-energy skin infection on the decline do not rise, difficulty in discharging of pus, burst do not hold back for a long time; And the deficiency of vital energy is lost the edema of fortune, the symptoms such as dysuria.The Radix Astragali mainly contains immunomodulating, antiviral, protects the liver effects such as protecting kidney, the harmful free radical of removing and antioxidation.In the Radix Astragali, main antiviral ingredients is astragalus polysaccharides.The antivirus action of the Radix Astragali is mainly to realize by the immunity of polysaccharide component enhancing body wherein.Astragalus polysaccharides Main Function is in vivo Promote immunity cell proliferation, strengthens cellular immunization and humoral immune function, and can induce body to produce some interferon.
Cortex Magnoliae Officinalis: bitter in the mouth, pungent, warm in nature, return spleen channel; Stomach warp; Large intestine channel, has circulation of qi promoting removing food stagnancy; Dampness is except full; The effect of lowering the adverse QI to relieve asthma, cures mainly stagnation of QI due to dyspepsia; Abdominal distention constipation; Retention of dampness in middle-JIAO, gastral cavity painful abdominal mass is vomited and diarrhoea; Expectorant is stopped up QI rising in reverse order; The fullness in the chest card such as breath with cough.
Rhizoma Kaempferiae: warm in nature, acrid in the mouth, returns stomach warp, has warming middle-JIAO, helps digestion, and the effect of pain relieving, cures mainly trusted subordinate's cold type of pain, stops dyspepsia, traumatic injury, toothache, the diet card such as do not disappear.
Fructus Corni: sour in the mouth, puckery, slightly warm in nature, returns liver, kidney channel, has liver and kidney tonifying, the effect of essence astringing and desertion stemming.For vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating collapse.The interior-heat card such as quench one's thirst.
Radix Et Caulis Acanthopanacis Senticosi: latin name Acanthopanacis Senticosi Radix et Rhizoma seu Caulis, acrid in the mouth, hardship, micro-sweet, warm in nature, enter spleen, kidney, heart channel, there is replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, the effect of expelling wind and removing dampness, soft for anemofrigid-damp arthralgia, lumbocrural pain, muscles and bones flaccidity, be slow in action, a little less than body weakness with emaciation, traumatic injury, fracture, edema, beriberi, the uncontrolled urination card such as itch.
Fructus Arctii: acrid in the mouth, hardship; Cold in nature, return lung, stomach warp, has dispelling wind and heat pathogens, heat-clearing and toxic substances removing rash, the lung qi dispersing sore-throat relieving swollen effect of faling apart, cure mainly anemopyretic cold, epidemic febrile disease from the beginning of; Wind heat or cough due to lung-heat, cough up phlegm not smooth; Laryngopharynx swelling and pain; Macule is not saturating; At the measles initial stage, rash goes out not smooth and rubella pruritus; The card such as sore swollen toxin and mumps.
Semen Arecae: bitter in the mouth, pungent, warm in nature, return stomach, large intestine channel, there is parasite killing, removing food stagnancy, circulation of qi promoting, diuretic, the effect of preventing the attack (or recurrence) of malaria, cures mainly abdominal pain due to worm stagnation, stagnant dysentery, tenesmus, edema beriberi, the cards such as malaria.
Semen Sesami Nigrum: sweet in the mouth, property is flat, returns liver, kidney, large intestine channel, has invigorating the liver and kidney, benefiting essence-blood, the effect that intestine moistening is dry, for dizziness and blurred vision, Hiccough and deaf, early whitening of beard and hair, post disease alopecia, the cards such as dryness of the intestine constipation.
Radix Caesalpiniae Radicis: bitter in the mouth, pungent, property is flat, has expelling wind and removing dampness, and the effect of removing toxic substances and promoting subsidence of swelling, cures mainly cold, fever, cough, laryngopharynx swelling and pain, toothache, rheumatic arthralgia, hepatitis, dysentery, stranguria, skin pruritus, the cards such as venom.
Fructus Litseae pungentis: bitter in the mouth, pungent, warm in nature, there is warming middle-JIAO to promote flow of QI, drying damp and strengthening spleen, the effect of removing toxic substances and promoting subsidence of swelling, cures mainly cold syndrome of the stomach stomachache, and heat-damp in summer is vomited and diarrhoea, and dyspepsia is glutted, dysmenorrhea, the skin infection card such as swell and ache.
Herba Fimbristylis dichotomae: sweet in the mouth, micro-puckery, cool in nature, there is removing toxic substances, diuresis, the effect of anthelmintic, cures mainly rheumatic arthritis, urinary tract infection, parasitosis.
Chinese medicine composition provided by the invention contains the material of killing or suppressing pathogenic microorganism, can directly kill the growth of polypide or inhibition polypide, worm's ovum, simultaneously, can also excitating organism immunity, strengthen leukocytic phagocytosis, enhancing antibody forms, the anticoccidial effect of this Chinese medicine composition, the growth that suppresses coccidiosis on the one hand, the immunologic function by regulating body on the other hand, produce nonspecific immunity with enhancing body premunition, thereby eliminate pathogen and alleviate it to histiocytic damage, recover the normal physiological function of body.
In described Chinese medicine composition, the weight portion of each crude drug is respectively Herba Artemisiae Annuae 45 weight portion～55 weight portions, Radix Glycyrrhizae 25 weight portion～35 weight portions, Resina Ferulae 30 weight portion～40 weight portions, Rhizoma Polygoni Cuspidati 55 weight portion～65 weight portions, Herba Taraxaci 45 weight portion～55 weight portions, Cortex Meliae 45 weight portion～55 weight portions, Radix Rehmanniae Preparata 25 weight portion～35 weight portions, Caulis Sargentodoxae 30 weight portion～40 weight portions, Herba Portulacae 25 weight portion～35 weight portions, Radix Bupleuri 30 weight portion～40 weight portions, Herba Selaginellae 25 weight portion～35 weight portions, Semen Vaccariae 20 weight portion～30 weight portions, the Radix Astragali 50 weight portion～60 weight portions, Cortex Magnoliae Officinalis 30 weight portion～40 weight portions, Rhizoma Kaempferiae 25 weight portion～35 weight portions, Radix Et Caulis Acanthopanacis Senticosi 35 weight portion～45 weight portions, Fructus Arctii 20 weight portion～30 weight portions, Semen Arecae 25 weight portion～35 weight portions, Semen Sesami Nigrum 20 weight portion～30 weight portions, Radix Caesalpiniae Radicis 25 weight portion～35 weight portions, Fructus Litseae pungentis 35 weight portion～45 weight portions and Herba Fimbristylis dichotomae 45 weight portion～55 weight portions.
Further preferably, in described Chinese medicine composition, the weight portion of each crude drug is respectively Herba Artemisiae Annuae 48 weight portion～52 weight portions, Radix Glycyrrhizae 28 weight portion～32 weight portions, Resina Ferulae 33 weight portion～37 weight portions, Rhizoma Polygoni Cuspidati 58 weight portion～62 weight portions, Herba Taraxaci 48 weight portion～52 weight portions, Cortex Meliae 48 weight portion～52 weight portions, Radix Rehmanniae Preparata 28 weight portion～32 weight portions, Caulis Sargentodoxae 33 weight portion～37 weight portions, Herba Portulacae 28 weight portion～32 weight portions, Radix Bupleuri 33 weight portion～37 weight portions, Herba Selaginellae 28 weight portion～32 weight portions, Semen Vaccariae 23 weight portion～27 weight portions, the Radix Astragali 53 weight portion～57 weight portions, Cortex Magnoliae Officinalis 33 weight portion～37 weight portions, Rhizoma Kaempferiae 28 weight portion～32 weight portions, Radix Et Caulis Acanthopanacis Senticosi 38 weight portion～42 weight portions, Fructus Arctii 23 weight portion～27 weight portions, Semen Arecae 28 weight portion～32 weight portions, Semen Sesami Nigrum 23 weight portion～27 weight portions, Radix Caesalpiniae Radicis 28 weight portion～32 weight portions, Fructus Litseae pungentis 38 weight portion～42 weight portions and Herba Fimbristylis dichotomae 48 weight portion～52 weight portions.
Most preferably, in described Chinese medicine composition, the weight portion of each crude drug is respectively Herba Artemisiae Annuae 50 weight portions, Radix Glycyrrhizae 30 weight portions, Resina Ferulae 35 weight portions, Rhizoma Polygoni Cuspidati 60 weight portions, Herba Taraxaci 50 weight portions, Cortex Meliae 50 weight portions, Radix Rehmanniae Preparata 30 weight portions, Caulis Sargentodoxae 35 weight portions, Herba Portulacae 30 weight portions, Radix Bupleuri 35 weight portions, Herba Selaginellae 30 weight portions, Semen Vaccariae 25 weight portions, the Radix Astragali 55 weight portions, Cortex Magnoliae Officinalis 35 weight portions, Rhizoma Kaempferiae 30 weight portions, Radix Et Caulis Acanthopanacis Senticosi 40 weight portions, Fructus Arctii 25 weight portions, Semen Arecae 30 weight portions, Semen Sesami Nigrum 25 weight portions, Radix Caesalpiniae Radicis 30 weight portions, Fructus Litseae pungentis 40 weight portions and Herba Fimbristylis dichotomae 50 weight portions.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, is specially:
Above-mentioned raw materials medicine component is mixed by weight, obtain mixture, put into reactor, add the water with respect to 3～5 times of mixture qualities, slow fire heating decocts 2～4 hours, and decoction liquor is filtered, filtering residue adds the water with respect to 2～4 times of the mixture qualities obtaining above, slow fire boiling 1～3 hour again, and decoction liquor is filtered again, filtrate is merged, concentrated except anhydrating, obtain mastic, dry, pulverize, obtain Chinese medicine composition composition powders.
The using method of the above-mentioned Chinese medicine composition of the present invention is that being stirred in of this Chinese medicine composition composition powders needed in the feedstuff of feeding, and the addition of this Chinese medicine composition composition powders is feeding quality 10%～15%, more preferably 12%.
The present invention also provides the preparation method of above-mentioned feedstuff, and it comprises:
The first step, prepares Chinese medicine composition feed additive according to the method described above;
Second step, the material composition of getting in proportion above-mentioned feedstuff is all grouped together, putting into multiplex mixer stirs 150 minutes, after taking-up, put into ring mode pulverizer and be ground into powder, then take out and put into dehydrator, the aridity of controlling dried material is 70%～80%, the time of smoking is 50～70 minutes, putting into after removal and cooling multiplex mixer stirs 190 minutes, after taking-up, put into ring mode bulking machine expanded, control the temperature of bulking machine between 70 ℃～80 ℃, the expanded time is 1～2 hour, the aridity of controlling material to be extruded is 80%～90%, after taking-up, proceed in ring mode grit machine and be produced into and precipitate hard particles feedstuff, then by 40 meshes, sieve.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
Embodiment 1 Chinese medicine composition composition powders 1
By Herba Artemisiae Annuae 50g, Radix Glycyrrhizae 30g, Resina Ferulae 35g, Rhizoma Polygoni Cuspidati 60g, Herba Taraxaci 50g, Cortex Meliae 50g, Radix Rehmanniae Preparata 30g, Caulis Sargentodoxae 35g, Herba Portulacae 30g, Radix Bupleuri 35g, Herba Selaginellae 30g, Semen Vaccariae 25g, Radix Astragali 55g, Cortex Magnoliae Officinalis 35g, Rhizoma Kaempferiae 30g, Radix Et Caulis Acanthopanacis Senticosi 40g, Fructus Arctii 25g, Semen Arecae 30g, Semen Sesami Nigrum 25g, Radix Caesalpiniae Radicis 30g, Fructus Litseae pungentis 40g and Herba Fimbristylis dichotomae 50g mix, obtain mixture, put into reactor, add the water of 3.5kg, slow fire heating decocts 3 hours, decoction liquor is filtered, filtering residue adds 2.5kg water, slow fire boiling 3 hours again, decoction liquor is filtered again, filtrate is merged, concentrated except anhydrating, obtain mastic, dry, pulverize, obtain Chinese medicine composition composition powders 1.
Embodiment 2 Chinese medicine composition composition powders 2
By Herba Artemisiae Annuae 48g, Radix Glycyrrhizae 28g, Resina Ferulae 33g, Rhizoma Polygoni Cuspidati 58g, Herba Taraxaci 48g, Cortex Meliae 48g, Radix Rehmanniae Preparata 28g, Caulis Sargentodoxae 33g, Herba Portulacae 28g, Radix Bupleuri 33g, Herba Selaginellae 28g, Semen Vaccariae 23g, Radix Astragali 53g, Cortex Magnoliae Officinalis 33g, Rhizoma Kaempferiae 28g, Radix Et Caulis Acanthopanacis Senticosi 38g, Fructus Arctii 23g, Semen Arecae 28g, Semen Sesami Nigrum 23g, Radix Caesalpiniae Radicis 28g, Fructus Litseae pungentis 38g and Herba Fimbristylis dichotomae 48g mix, obtain mixture, put into reactor, add the water of 3.5kg, slow fire heating decocts 3 hours, decoction liquor is filtered, filtering residue adds 2.5kg water, slow fire boiling 3 hours again, decoction liquor is filtered again, filtrate is merged, concentrated except anhydrating, obtain mastic, dry, pulverize, obtain Chinese medicine composition composition powders 2.
Embodiment 3 Chinese medicine composition composition powders 3
By Herba Artemisiae Annuae 52g, Radix Glycyrrhizae 32g, Resina Ferulae 37g, Rhizoma Polygoni Cuspidati 62g, Herba Taraxaci 52g, Cortex Meliae 52g, Radix Rehmanniae Preparata 32g, Caulis Sargentodoxae 37g, Herba Portulacae 32g, Radix Bupleuri 37g, Herba Selaginellae 32g, Semen Vaccariae 27g, Radix Astragali 57g, Cortex Magnoliae Officinalis 37g, Rhizoma Kaempferiae 32g, Radix Et Caulis Acanthopanacis Senticosi 42g, Fructus Arctii 27g, Semen Arecae 32g, Semen Sesami Nigrum 27g, Radix Caesalpiniae Radicis 32g, Fructus Litseae pungentis 42g and Herba Fimbristylis dichotomae 52g mix, obtain mixture, put into reactor, add the water of 3.5kg, slow fire heating decocts 3 hours, decoction liquor is filtered, filtering residue adds 2.5kg water, slow fire boiling 3 hours again, decoction liquor is filtered again, filtrate is merged, concentrated except anhydrating, obtain mastic, dry, pulverize, obtain Chinese medicine composition composition powders 1.
Embodiment 4 toxicology tests
Acute toxicity testing
Select 20 of Kunming mouses, female half and half, body weight (20+2) g, by Qingdao City's Experimental Animal Center, provided, powder 1 prepared by embodiment 1 is dissolved in distilled water, is prepared into the solution of 1g/ml, gavage mice, through preliminary experiment, fail to detect the LD of oral administration
50therefore, survey its maximum tolerated dose, with the administration volume of 2.0ml/10g body weight, gavage 2 times/d, interval 6h, gives observation post administration 7d, record animal dead and toxicity symptom, when experiment finishes, by all animals processing, dissect, the each main organs lesion tissue of perusal situation, gavages for 2 times after 140g crude drug/kg, animal activity, feed water inlet does not show any abnormalities, and observes 7d animal dead, and gross necropsy has no the obviously abnormal of main organs tissue.
Long term toxicity test
Select 40 male SD rats, weight (180 ± 20) g, by Qingdao City's Experimental Animal Center, provided, be divided at random 2 groups, blank group and Chinese drug-treated group, every group 20, blank group gives distilled water, the powder 1 that Chinese drug-treated group is prepared embodiment 1 is dissolved in distilled water, be prepared into the solution of 1g/ml, gavage rat, the amount of gavaging is 50g crude drug/kg, on every Mondays to gastric infusion 1 time in morning Saturday, 180d continuously, administration volume is 2mL/100g body weight, observe rat general state every day before administration and during administration, sign, food ration, drinking-water and feces situation.During administration 90d, after last administration 24h, each group extracts 6, male and female half and half; During 180d, after last administration 24h, each group extracts 6, male and female half and half; After drug withdrawal, 30d respectively organizes and extracts 6, male and female half and half, anaesthetize with urethane, from abdominal aortic, get blood, each group is all killed and gets animal, checks hematology and blood parameters, gets after blood, amass wealth by heavy taxation at once core, the internal organs such as liver,kidney,spleen, lung, adrenal gland, thyroid, thymus, testis, ovary, uterus, brain, prostate weigh, according to weight calculator official weight coefficient and make pathological examination.
On inspection, during successive administration, activity, body weight, food ration, stool and the hair luster degree no abnormality seen of animal, it is dead that animal has no, naked eyes have no obvious pathological changes, the inspection of each group rat peripheral hemogram is all in normal range, and the raw tea index of blood is all in normal range, and Chinese drug-treated group Rats Organs and Tissues coefficient does not have significant difference compared with blank group.
Embodiment 5 zooperies
Experimental agents: diclazuril, Jiangsu animal drug factory produces; Powder 1 prepared by the embodiment of the present invention 1.
Laboratory animal: provide totally 800 of the assorted chickens of the healthy meat of 30 ages in days by certain body raiser of Qingdao City.Do not infect after testing coccidiosis, do not use any coccidiosis chemoprophylaxis and treatment yet.
Test worm strain: Eimeria tenella egg capsule is provided by Qingdao Agricultural University's animal medicine laboratory, is the purebred Eimeria egg capsule liquid of 16.8 ten thousand/ml of egg capsule concentration.
Grouping and treatment:
800 chickens are divided into 5 groups at random, every group 200, be respectively: first infects administration group, to inoculate 100,000 Eimeria tenella egg capsules, occur after symptom, gavage powder 1 prepared by the embodiment of the present invention 1, be dissolved in water, obtain 1g/ml crude drug concentration, for ill chicken, gavage, every day, the amount of gavaging was 50ml; Second infects administration group, will inoculate 100,000 Eimeria tenella egg capsules, occur after symptom, every day feeding 1mg/kg diclazuril; Infect not administration group, will inoculate 100,000 Eimeria tenella egg capsules, occur after symptom not administration; Matched group, does not infect egg capsule, need not any Drug therapy yet.
The preparation of egg capsule: getting concentration is the egg capsule liquid 125ml of 16.8 ten thousand/ml, and water decile is diluted to 2 parts, is placed in CEN-TR IFU GETDL-5 type centrifuge, centrifugal 3 times of 3000r/min, each 10min.Centrifugal rear abandoning supernatant, taking-up lower floor egg capsule is made into the homogeneous solution of 210ml, and egg capsule liquid concentration is now 100,000/ml.
Inoculation egg capsule liquid: chicken gavages 1.0ml egg capsule liquid (100,000 egg capsules) to crop with syringe.Feeding and management method is raised routinely, the raising situation of timing every day viewing test chicken and incidence etc.
Therapeutic evaluation:
Feces is scored: with reference to the standard of Morehouse (1970), the 4d after artificial challenge starts to observe blood stool situation, scores, and make full cell mean by every chicken, 0 point of normal feces note, on average there is how much piling feces and just remember how many points respectively in every chicken every day.
Lesion score: with reference to the standard of (1970) such as John son, cut open all test chickens of inspection, according to the order of severity of cuing open pathological changes in inspection rear intestinal, score, without 0 point of pathological changes note, 1 point of Minimal change note, caecum wall thickening has little of 2 points of medium hemorrhage notes, inside has 3 points of a lot of clot notes, because of 4 points of the dead notes of coccidium infection.And make full cell mean.
Pathological changes value: with reference to the standard of M erck Sharp, i.e. lesion score average × 10 of every group of chicken.
Egg capsule numeration: infecting after egg capsule the 5th, 6, in the feces of 7d excretion, each group is divided respectively multiple spot selected part hemafecia and fresh normal feces 1g typically, take 1g after 7d mixes again.Add 9ml normal saline, being placed in mortar grinds gently, after becoming homogeneous solution, get 1ml and add saturated saline solution 8ml, be placed in 10ml test tube, then vibration shakes up, draw appropriate homogeneous solution topping up in M cM aster enumerator with glue head dropper, after being full of counting chamber, be placed in the micro-Microscopic observation counting of XS-212-201 physiology.First find first lattice in the counting chamber upper left corner to start counting, from top to bottom and from top to bottom " S " type counting, counts up to the worm's ovum number in 100 lattice of counting chamber.The worm's ovum number of 100 lattice is multiplied by 600 and is egg capsule counter value, according to said method count respectively each group of egg sac number.
Egg capsule index: egg capsule index=matched group or test group egg sac number/infect not administration group egg sac number × 100%.
Egg capsule value: the clear standard in reference angle field, egg capsule index is that egg capsule value is 0 below 1% time; In the time of 1%～25%, be designated as 5; 26%～50% is 10; In the time of 51%～75%, be 20; In the time of 76%～100%, be 40.
Weightening finish percentage rate: average weight gain/matched group group average weight gain × 100% of rate of body weight gain=each infected group.
Anticoccidial index (ACI): adopt the standard of Merck & Co., Inc., that is: anticoccidial index=(weightening finish percentage rate+survival rate)-(pathological changes value+egg capsule value).ACI≤120 are invalid, and ACI=120～160 are medium effective, and ACI=160～180 are good, and ACI>180 is outstanding.
Result:
Death condition after inoculation coccidian oocyst: after inoculation coccidian oocyst, death condition is in Table 1.First infects administration group, after inoculation egg capsule, 4d starts dead 16, dead 8 of 2d after medication, 3d dead 2, dead 26 altogether, second infects administration group 4d after inoculation egg capsule starts dead 19, dead 7 of 2d after medication, dead 3 of 3d, dead 29 altogether, the 3rd infects administration group 4d after inoculation egg capsule starts dead 16, dead 12 of 2d after medication, dead 7 of 3d, dead 4 of 4d, dead 39 altogether, infect dead 133 altogether of not administration groups, there is not death in matched group.
Table 1 is respectively organized chicken death situation after inoculating coccidian oocyst
| Group | Chicken number (only) | Death toll (only) | Mortality rate (%) |
| First infects administration group | 200 | 16 | 8 |
| Second infects administration group | 200 | 39 | 19.5 |
| Infect not administration group | 200 | 133 | 66.5 |
| Matched group | 200 | 0 | 0 |
Feces is scored: the first infection administration group and second infects administration group 4d chicken from inoculation egg capsule and starts to occur hemafecia, and 5d starts administration, and 6d hemafecia obviously reduces, and 5d hemafecia is the most serious, and it is the most serious to infect not administration group 6d, and 7d starts to reduce.On average scoring in Table 2 of each group.
Anticoccidial index (ACI)
First infects administration group and infects not administration group anticoccidial index and significantly improve (P<0.01) as can be seen from Table 2, and it also significantly improves (P<0.01) than the second infection administration group anticoccidial index.
Table 2 is respectively organized just egg capsule numeration situation of chicken manure after inoculating coccidian oocyst
Lesion score and pathological changes value: as can be seen from Table 3, the first infection administration group and the second infection administration group pathological changes value are all starkly lower than and infect not administration group, and the first infection administration group pathological changes value is lower compared with the second infection administration group.
Table 3 is tested lesion score and the pathological changes value of each group of chicken
Body weight and the Gain weight of the each test group chicken of table 4 off-test front and rear
All above-mentioned these intellectual properties of primary enforcement, do not set restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above, be only preferred embodiment of the present invention, is not the restriction of the present invention being made to other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (8)
1. a Chinese medicine composition that is used for the treatment of chicken coccidiosis, is characterized in that: crude drug comprises Herba Artemisiae Annuae, Radix Glycyrrhizae, Resina Ferulae, Rhizoma Polygoni Cuspidati, Herba Taraxaci, Cortex Meliae, Radix Rehmanniae Preparata, Caulis Sargentodoxae, Herba Portulacae, Radix Bupleuri, Herba Selaginellae, Semen Vaccariae, the Radix Astragali, Cortex Magnoliae Officinalis, Rhizoma Kaempferiae, Radix Et Caulis Acanthopanacis Senticosi, Fructus Arctii, Semen Arecae, Semen Sesami Nigrum, Radix Caesalpiniae Radicis, Fructus Litseae pungentis and Herba Fimbristylis dichotomae.
2. Chinese medicine composition as claimed in claim 1, is characterized in that: in described Chinese medicine composition, the weight portion of each crude drug is respectively Herba Artemisiae Annuae 45 weight portion～55 weight portions, Radix Glycyrrhizae 25 weight portion～35 weight portions, Resina Ferulae 30 weight portion～40 weight portions, Rhizoma Polygoni Cuspidati 55 weight portion～65 weight portions, Herba Taraxaci 45 weight portion～55 weight portions, Cortex Meliae 45 weight portion～55 weight portions, Radix Rehmanniae Preparata 25 weight portion～35 weight portions, Caulis Sargentodoxae 30 weight portion～40 weight portions, Herba Portulacae 25 weight portion～35 weight portions, Radix Bupleuri 30 weight portion～40 weight portions, Herba Selaginellae 25 weight portion～35 weight portions, Semen Vaccariae 20 weight portion～30 weight portions, the Radix Astragali 50 weight portion～60 weight portions, Cortex Magnoliae Officinalis 30 weight portion～40 weight portions, Rhizoma Kaempferiae 25 weight portion～35 weight portions, Radix Et Caulis Acanthopanacis Senticosi 35 weight portion～45 weight portions, Fructus Arctii 20 weight portion～30 weight portions, Semen Arecae 25 weight portion～35 weight portions, Semen Sesami Nigrum 20 weight portion～30 weight portions, Radix Caesalpiniae Radicis 25 weight portion～35 weight portions, Fructus Litseae pungentis 35 weight portion～45 weight portions and Herba Fimbristylis dichotomae 45 weight portion～55 weight portions.
3. Chinese medicine composition as claimed in claim 1 or 2, is characterized in that: in described Chinese medicine composition, the weight portion of each crude drug is respectively Herba Artemisiae Annuae 48 weight portion～52 weight portions, Radix Glycyrrhizae 28 weight portion～32 weight portions, Resina Ferulae 33 weight portion～37 weight portions, Rhizoma Polygoni Cuspidati 58 weight portion～62 weight portions, Herba Taraxaci 48 weight portion～52 weight portions, Cortex Meliae 48 weight portion～52 weight portions, Radix Rehmanniae Preparata 28 weight portion～32 weight portions, Caulis Sargentodoxae 33 weight portion～37 weight portions, Herba Portulacae 28 weight portion～32 weight portions, Radix Bupleuri 33 weight portion～37 weight portions, Herba Selaginellae 28 weight portion～32 weight portions, Semen Vaccariae 23 weight portion～27 weight portions, the Radix Astragali 53 weight portion～57 weight portions, Cortex Magnoliae Officinalis 33 weight portion～37 weight portions, Rhizoma Kaempferiae 28 weight portion～32 weight portions, Radix Et Caulis Acanthopanacis Senticosi 38 weight portion～42 weight portions, Fructus Arctii 23 weight portion～27 weight portions, Semen Arecae 28 weight portion～32 weight portions, Semen Sesami Nigrum 23 weight portion～27 weight portions, Radix Caesalpiniae Radicis 28 weight portion～32 weight portions, Fructus Litseae pungentis 38 weight portion～42 weight portions and Herba Fimbristylis dichotomae 48 weight portion～52 weight portions.
4. the Chinese medicine composition as described in claims 1 to 3, it is characterized in that: in described Chinese medicine composition, the weight portion of each crude drug is respectively Herba Artemisiae Annuae 50 weight portions, Radix Glycyrrhizae 30 weight portions, Resina Ferulae 35 weight portions, Rhizoma Polygoni Cuspidati 60 weight portions, Herba Taraxaci 50 weight portions, Cortex Meliae 50 weight portions, Radix Rehmanniae Preparata 30 weight portions, Caulis Sargentodoxae 35 weight portions, Herba Portulacae 30 weight portions, Radix Bupleuri 35 weight portions, Herba Selaginellae 30 weight portions, Semen Vaccariae 25 weight portions, the Radix Astragali 55 weight portions, Cortex Magnoliae Officinalis 35 weight portions, Rhizoma Kaempferiae 30 weight portions, Radix Et Caulis Acanthopanacis Senticosi 40 weight portions, Fructus Arctii 25 weight portions, Semen Arecae 30 weight portions, Semen Sesami Nigrum 25 weight portions, Radix Caesalpiniae Radicis 30 weight portions, Fructus Litseae pungentis 40 weight portions and Herba Fimbristylis dichotomae 50 weight portions.
5. the preparation method of Chinese medicine composition described in claim 1 to 4, is characterized in that:
Above-mentioned raw materials medicine component is mixed by weight, obtain mixture, put into reactor, add the water with respect to 3～5 times of mixture qualities, slow fire heating decocts 2～4 hours, and decoction liquor is filtered, filtering residue adds the water with respect to 2～4 times of the mixture qualities obtaining above, slow fire boiling 1～3 hour again, and decoction liquor is filtered again, filtrate is merged, concentrated except anhydrating, obtain mastic, dry, pulverize, obtain Chinese medicine composition composition powders.
6. a Chinese medicine composition composition powders that is used for the treatment of chicken coccidiosis, is characterized in that: crude drug comprises Herba Artemisiae Annuae, Radix Glycyrrhizae, Resina Ferulae, Rhizoma Polygoni Cuspidati, Herba Taraxaci, Cortex Meliae, Radix Rehmanniae Preparata, Caulis Sargentodoxae, Herba Portulacae, Radix Bupleuri, Herba Selaginellae, Semen Vaccariae, the Radix Astragali, Cortex Magnoliae Officinalis, Rhizoma Kaempferiae, Radix Et Caulis Acanthopanacis Senticosi, Fructus Arctii, Semen Arecae, Semen Sesami Nigrum, Radix Caesalpiniae Radicis, Fructus Litseae pungentis and Herba Fimbristylis dichotomae;
The preparation method of described Chinese medicine composition composition powders is specially mixes above-mentioned raw materials medicine component by weight, obtains mixture, puts into reactor, add the water with respect to 3～5 times of mixture qualities, slow fire heating decocts 2～4 hours, and decoction liquor is filtered, filtering residue adds the water with respect to 2～4 times of the mixture qualities obtaining above, slow fire boiling 1～3 hour again, and decoction liquor is filtered again, filtrate is merged, concentrated except anhydrating, obtain mastic, dry, pulverize, obtain Chinese medicine composition composition powders.
7. Chinese medicine composition composition powders as claimed in claim 6, is characterized in that: in described Chinese medicine composition composition powders, the weight portion of each crude drug is respectively Herba Artemisiae Annuae 45 weight portion～55 weight portions, Radix Glycyrrhizae 25 weight portion～35 weight portions, Resina Ferulae 30 weight portion～40 weight portions, Rhizoma Polygoni Cuspidati 55 weight portion～65 weight portions, Herba Taraxaci 45 weight portion～55 weight portions, Cortex Meliae 45 weight portion～55 weight portions, Radix Rehmanniae Preparata 25 weight portion～35 weight portions, Caulis Sargentodoxae 30 weight portion～40 weight portions, Herba Portulacae 25 weight portion～35 weight portions, Radix Bupleuri 30 weight portion～40 weight portions, Herba Selaginellae 25 weight portion～35 weight portions, Semen Vaccariae 20 weight portion～30 weight portions, the Radix Astragali 50 weight portion～60 weight portions, Cortex Magnoliae Officinalis 30 weight portion～40 weight portions, Rhizoma Kaempferiae 25 weight portion～35 weight portions, Radix Et Caulis Acanthopanacis Senticosi 35 weight portion～45 weight portions, Fructus Arctii 20 weight portion～30 weight portions, Semen Arecae 25 weight portion～35 weight portions, Semen Sesami Nigrum 20 weight portion～30 weight portions, Radix Caesalpiniae Radicis 25 weight portion～35 weight portions, Fructus Litseae pungentis 35 weight portion～45 weight portions and Herba Fimbristylis dichotomae 45 weight portion～55 weight portions.
8. a feedstuff, is characterized in that: comprise that Chinese medicine composition is as feed additive described in feedstuff main body and claim 1 to 5, described Chinese medicine composition feed additive accounts for 10%～15% of feeding quality.
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|---|---|---|---|---|
| CN106614285A (en) * | 2016-11-08 | 2017-05-10 | 绿春县卓阁生态农业发展有限公司 | Feeding method of colorful pheasants |
| CN115501273A (en) * | 2021-06-23 | 2022-12-23 | 广西大学 | Application of traditional Chinese medicine compound effective extract in preparation of medicine for resisting eimeria tenella |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101129673A (en) * | 2007-08-17 | 2008-02-27 | 李培英 | Pure traditional Chinese medicine formulated product for preventing and treating coccidiosis |
| CN101744932A (en) * | 2008-12-15 | 2010-06-23 | 天津中敖生物科技有限公司 | Traditional Chinese medicine composition for preventing and treating coccidiosis of poultry |
| CN103251858A (en) * | 2013-05-13 | 2013-08-21 | 安徽农业大学 | Traditional Chinese medicine composite for resisting parasite of free-ranging chicken and preparation method thereof |
| CN103272091A (en) * | 2013-05-31 | 2013-09-04 | 天津生机集团股份有限公司 | Traditional Chinese medicinal oral preparation for treating chicken coccidiosis and preparation method thereof |
-
2013
- 2013-10-23 CN CN201310504033.5A patent/CN103721147B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101129673A (en) * | 2007-08-17 | 2008-02-27 | 李培英 | Pure traditional Chinese medicine formulated product for preventing and treating coccidiosis |
| CN101744932A (en) * | 2008-12-15 | 2010-06-23 | 天津中敖生物科技有限公司 | Traditional Chinese medicine composition for preventing and treating coccidiosis of poultry |
| CN103251858A (en) * | 2013-05-13 | 2013-08-21 | 安徽农业大学 | Traditional Chinese medicine composite for resisting parasite of free-ranging chicken and preparation method thereof |
| CN103272091A (en) * | 2013-05-31 | 2013-09-04 | 天津生机集团股份有限公司 | Traditional Chinese medicinal oral preparation for treating chicken coccidiosis and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 刘传敏 等: "几种中草药复方对柔嫩艾美耳球虫感染鸡的防治效果", 《河南畜牧兽医(综合版)》 * |
| 李宏娟 等: "中药复方对鸡柔嫩艾美尔球虫病的疗效观察", 《华北农学报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106614285A (en) * | 2016-11-08 | 2017-05-10 | 绿春县卓阁生态农业发展有限公司 | Feeding method of colorful pheasants |
| CN115501273A (en) * | 2021-06-23 | 2022-12-23 | 广西大学 | Application of traditional Chinese medicine compound effective extract in preparation of medicine for resisting eimeria tenella |
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| CN103721147B (en) | 2016-08-17 |
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