CN104306668A - Traditional Chinese medicine composition for treating icterus neonatorum with symptom of retention and fumigation of damp-heat and preparation method thereof - Google Patents

Traditional Chinese medicine composition for treating icterus neonatorum with symptom of retention and fumigation of damp-heat and preparation method thereof Download PDF

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CN104306668A
CN104306668A CN201410554482.5A CN201410554482A CN104306668A CN 104306668 A CN104306668 A CN 104306668A CN 201410554482 A CN201410554482 A CN 201410554482A CN 104306668 A CN104306668 A CN 104306668A
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刘宁
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Abstract

The invention discloses a traditional Chinese medicine composition for treating icterus neonatorum with symptom of retention and fumigation of damp-heat and a preparation method thereof. The composition is prepared from the following medicinal raw materials: moellendorf's spidemoss herb, herba pteridis multifidae, Indian kalimeris herb, symplocos chinensis root, slender dutchmanspipe root, common bombax flower, puberulous glochidion branchlet and leaf, tuber fern, serissa serissoides, rabdosia lophanthide, hypericum japonicum, swertia mileensis, chirita fimbrisepala, little groundcherry herb fruit, asparagus, horehound, vetch, silybum marianum, piemarker, salvia chinensis, hupeh bauhinia root, shortleaf kyllinga herb, elaeagnus umbellata, turtle shell and cornu procaprae gutturosae. The traditional Chinese medicine composition for treating icterus neonatorum with symptom of retention and fumigation of damp-heat has the effects of clearing heat, inducing diuresis, removing icterus and calming liver wind, is capable of carrying out syndrome differentiation and treatment base on the holistic view by utilizing traditional Chinese medical theory, and is prepared from purely natural traditional Chinese medicinal materials with strict compatibility; and the traditional Chinese medicinal materials with different drug properties are scientifically matched to directly reach the focus. The traditional Chinese medicine composition has the advantages of convenience in medicine taking, short course of treatment, high curative effect, low cost, safety and no toxic or side effect.

Description

A kind ofly treat Chinese medicine composition of neonate retention and fumigation of damp-heat inside the body type jaundice and preparation method thereof
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Technical field
The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly a kind ofly treating Chinese medicine composition of neonate retention and fumigation of damp-heat inside the body type jaundice and preparation method thereof.
 
Background technology
Neonatal jaundice is one of introduction stage common sympton, the neonate especially in a week, both can be physiological phenomenon, and can be again the main manifestations of various diseases.Although the rising or not bery high of bilirubin severe, when there is the high risk factors such as anoxia, acidosis, infection, can cause bilirubin encephalopathy, mortality rate is high, the many existence of survivor nervous system sequela at a specified future date simultaneously.
Neonatal jaundice is divided into physiologic jaundice and pathological jaundice.Physiologic jaundice: due to neonatal bilirubin metabolism feature, namely after birth bilirubinic generation too much and metabolism and discharge capacity low, the bilirubin level in blood is caused to raise, there is temporary, slight jaundice process in the term infant of about 50% ~ 60% and the premature infant of 80%, is called physiologic jaundice.Pathological jaundice: neonatal jaundice occurs that following situations need be thought of as pathological jaundice for the moment: 1. jaundice occurs early: occur in raw latter 24 hours; 2. degree weight: term infant serum bilirubin level >220.6 & micro; Mol/L(12.9mg/dl), premature infant >256.5 μm of ol/L(15mg/dl); 3. serum conjugated bilirubin increases >26 & micro; Mol/L(1.5mg/dl); 4. progress is fast: serum bilirubin to rise >85 & micro every day; Mol/L(5mg/dl); 5. the jaundice persistent period is longer, and more than 2 ~ 4 weeks, or Progressive symmetric erythrokeratodermia increased the weight of or moves back and reappear.
The cause of disease of pathological jaundice is more, and often has Different types of etiopathogenises to exist simultaneously.1, bilirubin generates too much: the bilirubinic main source of neonatal period produces through a series of metabolism after the hematoclasis of aging under normal circumstances.Neonatal period makes hematoclasis increase due to the various cause of disease, and bilirubin generates too much, causes unconjugated bilirubin to increase.2, hepatocyte picked-up and conjugated bilirubin inferior capabilities.3, bilirubin excretion is abnormal: hepatocyte excretory function obstacle or bile duct are obstructed, and obstructive jaundice can occur, and conjugated bilirubin is increased.As having hepatic dysfunction simultaneously, also can increase with unconjugated bilirubin, and cause Combination hyperbilirubinemia.4, enterohepatic circulation increases: postpone as congenital intestinal atresia, pyloric hypertrophy, megacolon, meconium ileus, hunger, nursing delay, drug-induced enteroparalysis etc. all can make meconium discharge, increase bilirubinic resorption and receive; Breast-feeding infant may increase due to beta-glucuronidase enzyme content and activity in intestinal, impels bilirubin enterohepatic circulation to increase, all can cause hyperbilirubinemia.
Hyperbilirubinemia of newborn except skin jaundice in various degree, also because of the difference of pathogenesis etiology with corresponding clinical manifestation.1. hemolytic disease of newborn comprises Rh and ABO Hemolysis.Feature occurs in 24 hours after jaundice Chang Yusheng, makes fast progress, serum bilirubin >256.5 ~ 342 μm ol/L(15 ~ 20mg/dl), severe patient can with anemia, hepatosplenomegaly, even fetus edema, bilirubin encephalopathy etc.2. when grave infection infects (as septicemia, changing brain, severe pneumonia etc.), jaundice can be caused to increase the weight of.Intrauterine infection jaundice occurs that early, PNI is evening slightly, simultaneously with the various performances infected.3. enclose product factor and mainly comprise pathology childbirth, perinatal hypoxia, mother and neonate medication impact.Jaundice occurs for 2 ~ 3 days, and 5 ~ 6 days peaks are moderate.4. breast milk jaundice is divided into Early onset and delayed.The former is also known as breast feeding jaundice, thinks relevant with breast feeding quantity not sufficient, takes in and makes enterokinesia reduce less, and meconium is discharged and postponed and cause enterohepatic circulation increase.The latter may be relevant with beta-glucuronidase enzymatic activity height in breast milk, heavily absorbs, increase enterohepatic circulation after the conjugated bilirubin in intestinal is hydrolyzed.There is jaundice in 3 ~ 4 days in Breast milk jaundice, within 5 ~ 7 days, reach peak, within 2 ~ 3 weeks, disappear after raw; There is jaundice in 6 ~ 8 days in delayed, within 2 ~ 3 weeks, reach peak, within 6 ~ 12 weeks, can disappear after Chi Zhisheng after raw.The diagnosis of breast milk jaundice just can need be made after eliminating other pathological factors.
5. conjugated hyperbilirubinemia: clinical take obstructive jaundice as feature, i.e. skin, yellow sclera, stool complexion changed is light or greyish white, and urine color depth is yellow, hepatosplenomegaly and liver function injury.Complication: septicemia, pneumonia of newborn, biliary atresia, breast milk jaundice.
Western medical treatment: 1. Light therapy reduces serum unconjugated bilirubin simply effective method.Crouched by neonate in phototherapy case, eyes black eyeshield protection, in order to avoid injured retina, perineum, podex diaper hide, and all the other are all exposed.Irradiate with machine glazing or dual light, continue 2 ~ 48 hours (being generally no more than 4 days), bilirubin drops to less than 7 milligrams/deciliter can stop treatment.2. exchange transfusion: change-blood can reduce bilirubin effectively, the erythrocyte of the sensitization of swapping out and alleviate anemia.But change-blood needs certain condition, also can produce some untoward reaction, therefore strictly should grasp indication.3. Drug therapy: supply albumin, correct metabolic acidosis, Liver enzyme inducer (as phenobarbital), vein uses immunoglobulin.But the available species of western medical treatment neonatal jaundice medicine is limited, and price is high, and therapeutic scheme is single, cause certain financial burden to patient home, stress etc.
Chinese medicine is thought, neonatal jaundice belongs to pregnant jaundice category.With skin appearance after baby due, pregnant jaundice occurs that yellow cellulitis is for feature.It is relevant that factor reported by cause and tire, therefore claim " pregnant jaundice " or " tire cellulitis ".Pregnant jaundice is divided into physiological and pathologic two class.Physiological pregnant jaundice occurs mostly after raw for 2-3 days, and within 4-6 days, reach peak, within 7-10 days, disappear, premature infant's persistent period is longer, apart from outside slight inappetence, generally without other clinical symptoms.If namely there is yellow cellulitis in raw latter 24 hours, still do not disappear after 3 weeks, even continue to deepen, or reappear after disappearing, be pathological jaundice.The cause of disease forming pathologic pregnant jaundice is a lot, is mainly tire and reports wet accumulateing, due to pregnant female element accumulate wet contain or in accumulate damp and hot poison, lose in fetus, or because of when tire produces, after birth, baby experiences caused by toxic dampness and heat.If pregnant mother is weak and sickly, QI and blood element loses, and can cause fetus natural endowment not enough, deficiency of spleen-YANG is weak, endogenous damp formation; Or by damp is invaded after life, conversion of dampness into cold, stagnation of cold-damp.Also have children's's innate deficiency, blockage of the vessel, or damp-heat accumulation Liver Channel with the passing of time, the strongly fragrant resistance of QI and blood, all can form primary disease.First pregnant jaundice for main symptom, dialectical will distinguish its character with skin, appearance jaundice, and the time occurred with yellow cellulitis, degree, disappear situation, in conjunction with General Symptoms distinguish genus physiological pregnant jaundice or pathologic pregnant jaundice.Next distinguishes the yin-yang attribute of pregnant jaundice, and all yellow cellulitis are bright and lustrous as Fructus Citri tangerinae, and agitation is crowed more, and door likes drink yearningly, red tongue with yellowish and greasy fur, belongs to YANG jaundice; Yellow cellulitis color and luster is dark and gloomy, and do not move back for a long time, Mental fatigue limb is cool, abdominal distention and little diet, loose stool, and pale tongue with thin fur then belongs to YIN jaundice.
Physiologic jaundice can disappear voluntarily, and do not need treatment, pathological jaundice needs to carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs: 1. retention and fumigation of damp-heat inside the body syndrome: appearance yellowing of the skin, bright and lustrous as Fructus Citri tangerinae, sob is loud, hesitating to suck, thirsty dry lip, or has heating, constipation, urine is deep yellow, red tongue, yellow and greasy fur.2. cold temperature retardance syndrome: appearance yellowing of the skin, color and luster is dark and gloomy, does not move back lastingly, lethargy, and extremities being not warm is indigestion and loss of appetite, and the thin color in large loose stool is greyish white, oliguria, pale tongue, and tongue is greasy in vain.3. the stagnation of QI stasis of blood amasss syndrome: appearance yellowing of the skin, and color is deepened gradually, dark and gloomy simple and unadorned, and under right flank, mass in the abdomen matter is hard, and abdominal flatulence, blue veins appears, or sees ecchymosis, epistaxis, and color of the lip is dark red, and tongue is shown in petechia, yellow fur.
 
Summary of the invention
Technical problem to be solved by this invention is, need a kind of Chinese medicine composition improving neonate retention and fumigation of damp-heat inside the body type jaundice, the effective ingredient scientific compatibility of each raw medicinal material, treatment neonate retention and fumigation of damp-heat inside the body type jaundice not only has the advantage of doctor trained in Western medicine, and have the advantages that doctor trained in Western medicine do not have, as from entirety, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, with strong points, evident in efficacy, treating both the principal and secondary aspects of a disease, safely, effectively, medical expense is lower.The present invention combines clinical experience for many years on the basis of traditional medicine, adopts modern processing method meticulously to develop, can teach the misery large degree solving patient.
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine composition for the treatment of neonate retention and fumigation of damp-heat inside the body type jaundice, wherein, described Chinese medicine composition comprises following raw medicinal material: Herba Selaginellae Moellendorfii, Herba Pteridis Multifidae, Herba Kalimeridis, Radix Symplocoris chinensis, little Sinomenium acutum, Flos Bombacis Malabarici, Folium glochidionis puberi, Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae), Radix Serissae, Herba Rabdosiae Lophanthoidis, Herba Hyperici Japonici, Herba Swertiae Mileensis, Rhizoma Chiritae Fimbrisepalae, Herba seu Fructus Physalis Minimae, asparagus, Herba lagopsis supinae, Herba Viviae Sativae, Herba Silybi mariani, Herba Abutili, Herba Salviae Chinensis, Radix Bauhiniae Hupehanae, Herba Kyllingae, Fructus Elaeagni Umbellatae, Carapax Trionycis and Cornu procaprae gutturosae.
Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Herba Selaginellae Moellendorfii 10-25 weight portion, Herba Pteridis Multifidae 12-24 weight portion, Herba Kalimeridis 10-20 weight portion, Radix Symplocoris chinensis 1-3 weight portion, little Sinomenium acutum 1-3 weight portion, Flos Bombacis Malabarici 10-25 weight portion, Folium glochidionis puberi 1-3 weight portion, Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae) 12-26 weight portion, Radix Serissae 13-28 weight portion, Herba Rabdosiae Lophanthoidis 10-20 weight portion, Herba Hyperici Japonici 14-28 weight portion, Herba Swertiae Mileensis 10-20 weight portion, Rhizoma Chiritae Fimbrisepalae 13-24 weight portion, Herba seu Fructus Physalis Minimae 10-20 weight portion, asparagus 15-20 weight portion, Herba lagopsis supinae 13-26 weight portion, Herba Viviae Sativae 10-20 weight portion, Herba Silybi mariani 14-29 weight portion, Herba Abutili 12-20 weight portion, Herba Salviae Chinensis 10-20 weight portion, Radix Bauhiniae Hupehanae 10-23 weight portion, Herba Kyllingae 14-26 weight portion, Fructus Elaeagni Umbellatae 15-29 weight portion, Carapax Trionycis 10-20 weight portion and Cornu procaprae gutturosae 10-18 weight portion.
Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Herba Selaginellae Moellendorfii 20-25 weight portion, Herba Pteridis Multifidae 20-24 weight portion, Herba Kalimeridis 15-20 weight portion, Radix Symplocoris chinensis 2-3 weight portion, little Sinomenium acutum 2-3 weight portion, Flos Bombacis Malabarici 20-25 weight portion, Folium glochidionis puberi 2-3 weight portion, Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae) 20-26 weight portion, Radix Serissae 20-28 weight portion, Herba Rabdosiae Lophanthoidis 15-20 weight portion, Herba Hyperici Japonici 20-28 weight portion, Herba Swertiae Mileensis 15-20 weight portion, Rhizoma Chiritae Fimbrisepalae 20-24 weight portion, Herba seu Fructus Physalis Minimae 15-20 weight portion, asparagus 18-20 weight portion, Herba lagopsis supinae 20-26 weight portion, Herba Viviae Sativae 15-20 weight portion, Herba Silybi mariani 20-29 weight portion, Herba Abutili 18-20 weight portion, Herba Salviae Chinensis 15-20 weight portion, Radix Bauhiniae Hupehanae 20-23 weight portion, Herba Kyllingae 20-26 weight portion, Fructus Elaeagni Umbellatae 20-29 weight portion, Carapax Trionycis 15-20 weight portion and Cornu procaprae gutturosae 15-18 weight portion.
Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Herba Selaginellae Moellendorfii 10 weight portion, Herba Pteridis Multifidae 12 weight portion, Herba Kalimeridis 10 weight portion, Radix Symplocoris chinensis 1 weight portion, little Sinomenium acutum 1 weight portion, Flos Bombacis Malabarici 10 weight portion, Folium glochidionis puberi 1 weight portion, Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae) 12 weight portion, Radix Serissae 13 weight portion, Herba Rabdosiae Lophanthoidis 10 weight portion, Herba Hyperici Japonici 14 weight portion, Herba Swertiae Mileensis 10 weight portion, Rhizoma Chiritae Fimbrisepalae 13 weight portion, Herba seu Fructus Physalis Minimae 10 weight portion, asparagus 15 weight portion, Herba lagopsis supinae 13 weight portion, Herba Viviae Sativae 10 weight portion, Herba Silybi mariani 14 weight portion, Herba Abutili 12 weight portion, Herba Salviae Chinensis 1-20 weight portion, Radix Bauhiniae Hupehanae 10 weight portion, Herba Kyllingae 14 weight portion, Fructus Elaeagni Umbellatae 15 weight portion, Carapax Trionycis 10 weight portion and Cornu procaprae gutturosae 10 weight portion.
Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Herba Selaginellae Moellendorfii 25 weight portion, Herba Pteridis Multifidae 24 weight portion, Herba Kalimeridis 20 weight portion, Radix Symplocoris chinensis 3 weight portion, little Sinomenium acutum 3 weight portion, Flos Bombacis Malabarici 25 weight portion, Folium glochidionis puberi 3 weight portion, Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae) 26 weight portion, Radix Serissae 28 weight portion, Herba Rabdosiae Lophanthoidis 20 weight portion, Herba Hyperici Japonici 28 weight portion, Herba Swertiae Mileensis 20 weight portion, Rhizoma Chiritae Fimbrisepalae 24 weight portion, Herba seu Fructus Physalis Minimae 20 weight portion, asparagus 20 weight portion, Herba lagopsis supinae 26 weight portion, Herba Viviae Sativae 20 weight portion, Herba Silybi mariani 29 weight portion, Herba Abutili 20 weight portion, Herba Salviae Chinensis 20 weight portion, Radix Bauhiniae Hupehanae 23 weight portion, Herba Kyllingae 26 weight portion, Fructus Elaeagni Umbellatae 29 weight portion, Carapax Trionycis 20 weight portion and Cornu procaprae gutturosae 18 weight portion.
For solving the problems of the technologies described above, present invention also offers a kind of preparation method of described Chinese medicine composition, wherein, when the dosage form of described Chinese medicine composition is granule, its preparation method is:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 3 ~ 6 times, mixture is the ethanol of 80% ~ 90%, be heated to boiling reflux 2 ~ 4 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 55 ~ 65 DEG C subsequently under vacuum 0.07 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 150 ~ 165 DEG C of spray dryer, leaving air temp 70 ~ 75 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.5 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 45 ~ 50 DEG C of dryings, obtains granule.
When the dosage form of described Chinese medicine composition is capsule and dripping agent, its preparation method is:
The first step, by Herba Selaginellae Moellendorfii, Herba Pteridis Multifidae and Herba Kalimeridis mixing, add relative to mixture 2 times ~ 4 times amount determining alcohol be 75% ~ 85% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 4 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 60 DEG C of relative densities is the mastic of 1.20 ~ 1.22, for subsequent use;
Second step, is mixed in proportion described for residue raw medicinal material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.23 ~ 1.25;
3rd step, the mastic mixing that the first step, second step are obtained, 65 DEG C ~ 75 DEG C reduced vacuum dryings, get dry extract powder, pulverized by described dried cream powder, filters obtain fine powder through 90-120 order;
4th step, adds the vegetable oil of 1-2 times amount, mix homogeneously by the fine powder that the 3rd step obtains, then load in ' Yanming ' capsules for clearing, become capsule and dripping agent.
The dosage form of described Chinese medicine composition is: sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, capsule and dripping agent, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster and syrup.
The invention has the beneficial effects as follows: the effective ingredient scientific compatibility of each raw medicinal material, treatment neonate retention and fumigation of damp-heat inside the body type jaundice not only has the advantage of doctor trained in Western medicine, and have the advantages that doctor trained in Western medicine do not have, and as from entirety, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, with strong points, evident in efficacy, healing time is short, treating both the principal and secondary aspects of a disease, safely, effectively, medical expense is lower.The present invention combines clinical experience for many years on the basis of traditional medicine, adopts modern processing method meticulously to develop, can teach the misery large degree solving patient.
 
Detailed description of the invention
Motherland's medical science is thought, the pathological changes internal organs of pregnant jaundice are at liver and gall, taste.Its pathogeny is mainly in damp-heat in the spleen and stomach, cold-damp accumulates, the liver failing to maintain the normal flow of QI, and bile is excessive and cause jaundice, and then the stagnation of QI stasis of blood is amassed for a long time.Because of the difference of the cause of disease, the course of disease, body constitution, disease is also different, wherein retention and fumigation of damp-heat inside the body person, and heat is YANG pathogen, therefore yellow distinct in Pericarpium Citri tangerinae.Excessive noxious heat, yellow cellulitis can be deepened rapidly, and damp and hot fire-transformation, the evil the moon of fainting that falls into, then there will be the dangerous sign or phenomenon of coma, tic.If healthy energy is not propped up, gas yang deficiency declines, and can become collapse danger card.Due to neonatal weakness of spleen and stomach, therefore need turn round and look in therapeutic process and protect the QI of the spleen and stomach day after tomorrow, the agent by bitter cold can not be crossed, in case bitter cold is upset one's stomach, gram cut down healthy energy.
Therefore the invention provides a kind of Chinese medicine composition for the treatment of neonate damp and hot melancholia type jaundice, wherein, described Chinese medicine composition comprises following raw medicinal material: Herba Selaginellae Moellendorfii, Herba Pteridis Multifidae, Herba Kalimeridis, Radix Symplocoris chinensis, little Sinomenium acutum, Flos Bombacis Malabarici, Folium glochidionis puberi, Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae), Radix Serissae, Herba Rabdosiae Lophanthoidis, Herba Hyperici Japonici, Herba Swertiae Mileensis, Rhizoma Chiritae Fimbrisepalae, Herba seu Fructus Physalis Minimae, asparagus, Herba lagopsis supinae, Herba Viviae Sativae, Herba Silybi mariani, Herba Abutili, Herba Salviae Chinensis, Radix Bauhiniae Hupehanae, Herba Kyllingae, Fructus Elaeagni Umbellatae, Carapax Trionycis and Cornu procaprae gutturosae.
This prescription for Therapeutic Principle, selects Herba Selaginellae Moellendorfii, Herba Pteridis Multifidae, Herba Kalimeridis, Radix Symplocoris chinensis, little Sinomenium acutum, Flos Bombacis Malabarici, Folium glochidionis puberi, Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae), Radix Serissae, Herba Rabdosiae Lophanthoidis, Herba Hyperici Japonici, Herba Swertiae Mileensis clearing away heat-damp and promoting diuresis with heat-clearing and dampness-resolving, suppressing the hyperactive liver to relieve the wind syndrome.Rhizoma Chiritae Fimbrisepalae, Herba seu Fructus Physalis Minimae, asparagus, Herba lagopsis supinae, Herba Viviae Sativae, Herba Silybi mariani, Herba Abutili, Herba Salviae Chinensis, Radix Bauhiniae Hupehanae, Herba Kyllingae, Fructus Elaeagni Umbellatae clearing away heat-damp and promoting diuresis, Carapax Trionycis and Cornu procaprae gutturosae suppressing the hyperactive liver to relieve the wind syndrome.
Herba Selaginellae Moellendorfii: nature and flavor are sweet pungent is flat.1. " vegetation is side just ": " pungent, flat." 2. " Traditional Chinese Medicine in Sichuan will ": " is lightly seasoned micro-pungent, and property is put down, nontoxic." 3. " Jiangxi medical herbs ": " sweet in the mouth, property is put down." function cures mainly hemostasis, heat clearing away, dampness removing.Control haematemesis, hemorrhoidal bleeding, have blood in stool, metrorrhagia, wound hemorrhage, jaundice, gonorrhea, infantile convulsion.1. " Bencao Tujing ": " main viscerotoxic hematochezia, with point end such as Radix Astragali, rice drink-service two money." 2. " vegetation is side just ": " hemostasis, qualcomm meridian, relieving palpitation relieving restlessness, settling five organs.Control the inferior blood, collapse pouring, cutter axe bleeding due to trauma." 3. " classifying herbal ": " controls bleeding hemorrhoids, relieving heat toxin, and controls cough, burn." 4. " Traditional Chinese Medicine in Sichuan will ": " heat-clearing and toxic substances removing.Control haematemesis." 5. " Zhejiang natural resources of Chinese medicinal materials register ": " controls children's wind-heat." 6. " Guizhou medical herbs ": " clearing away heat-damp and promoting diuresis, nourishing YIN to lower pathogenic fire."
Herba Pteridis Multifidae: lightly seasoned micro-hardship, cold in nature.1. " the SHENGCAO property of medicine is standby to be wanted ": " acrid in the mouth, property is put down." 2. " classifying herbal ": " is cool in nature, nontoxic." 3. " Fujian traditional herbal medicine ": " is salty, cold, micro-poison." 4. " book on Chinese herbal medicine pushes away old ": " is bitter, cold." 5. Guangzhou army " conventional Chinese herbal medicine handbook ": " sweet light micro-hardship, cold." return through 1. " Quanzhou book on Chinese herbal medicine ": " enters kidney, stomach two warp." 2. " east, Fujian book on Chinese herbal medicine ": " enters large intestine, kidney, the heart, liver four warp." function cures mainly clearing away heat-damp and promoting diuresis, cooling blood for hemostasis, subduing swelling and detoxicating.Control icterohepatitis, enteritis, bacillary dysentery, stranguria with turbid discharge, leukorrhagia, spit blood, epistaxis, has blood in stool, hematuria, tonsillitis, parotitis, carbuncle sore tumefacting virus, eczema.1. " the SHENGCAO property of medicine is standby to be wanted ": " wash infantile malnutrition, treatment, hemorrhoid, loose poison, applies skin ulcer." " is controlled Serpentis and is stung all poison, knife injury, and energy hemostasia and promoting granulation, juice rectification of pounding takes, and slag applies affected part.Grinding into powder harvests and store controls pain due to disorder of QI." 2. " south of the Five Ridges gather medicinal herbs record ": " dries as end, controls pain due to disorder of QI burning pain." 3. " Zhiwu Mingshi Tukao ": " controls five types of stranguria, only urine pain." 4. " classifying herbal ": " controls all pyretic toxicity, and detumescence, relieves inflammation or internal heat.Control carbuncle skin ulcer, acute mastitis, stranguria." 5. " will planted by middle traditional Chinese medicines ": " antidiarrheal." 6. " Guizhou side among the people medicine collection ": " is antipyretic, diuresis.Control infantile convulsion, night cries." 7. " will planted by Guangxi medicine ": " clear large intestine, lung-heat.Control hot bloody dysentery and toothache, emesis blood." 8. " illustrated handbook planted by middle traditional Chinese medicines ": " controls scabies." 9. " Quanzhou book on Chinese herbal medicine ": " controls damp and hot urinary obstruction, stranguria with blood, laryngopharynx swelling and pain." 10. " Hunan medicine will ": " controls infantile malnutrition, flu, corneal nebula."
Herba Kalimeridis: nature and flavor are pungent is cool.1. " praise and help book on Chinese herbal medicine ": be " pungent, flat, nontoxic." 2. " beautiful Chinese catalpa medicine solution ": " bitter in the mouth is pungent, and gas is put down." 3. " occupying diet spectrum with breath ": " Gan Xin is cool." return through 1. " detailed outline ": " enters positive bright blood system." 2. " jade seizes medicine solution ": " start with lunar lung, liver channel of foot-Jueyin." function cures mainly removing heat from blood, heat clearing away, dampness removing, removing toxic substances.Control haematemesis, epistaxis, dysentery, wound hemorrhage, malaria, jaundice, edema, stranguria with turbid discharge, pharyngalgia, sore throat, hemorrhoid, carbuncle, erysipelas, venom.1. " Japan hanako materia medica ": " root, leaf, broken stagnated blood, supports fresh blood, only epistaxis, spits blood, alloy skin ulcer, and disconnected dysentery, separates alcoholic jaundice and all bacteriums; Life is smash deposited Serpentis and is stung." 2. " detailed outline ": " root, leaf, main all malarias and spasm and pain in the abdomen, hemorrhoid." 3. " herbal classic is met former ": " controls married woman's stranguria with turbid discharge, anal fistula." 4. " medical center bun is wanted ": " the kidney invigorating life, eliminating cold-damp, warm uterus, parasite killing.Control infantile malnutrition." 5. " interrogating book on Chinese herbal medicine ": " is smash juice and is coated with impetigo and innominate toxic swelling." " smashes even with leaf with winter honey, applies positive disease innominate toxic swelling, and the person that do not burst can fall apart." 6. " Fujian traditional herbal medicine ": " stasis of blood hemostasis alive, eliminating carbuncle, removing toxic substances." 7. " Traditional Chinese Medicine in Sichuan will ": " helps digestion long-pending glutted and breast knot flatulence, and except damp and hot, diuresis, brings down a fever, and cough-relieving is coughed, removing toxic substances, treating snakebite." 8. " Yunnan Chinese herbal medicine ": " root: expelling wind and cold, relieving cough and asthma.Control bronchitis, bronchial asthma, rheumatic arthralgia, infantile hernia." 9. " register planted by Guangxi medicine ": " clearing away heat and expelling pathogen in the exterior.Control affection due to external wind and heat."
Radix Symplocoris chinensis: nature and flavor are bitter, cold.1. " Nanning City's medicine will ": " bitter, cold, slightly poisonous." 2. " Guangxi Chinese medicinal herbal ": " mildly bitter flavor, property is put down, slightly poisonous." function cures mainly clearing away heat-damp and promoting diuresis, and reduce phlegm preventing the attack (or recurrence) of malaria.Cure cold heating, malaria, bones and muscles pain, furuncle.1. " Zhiwu Mingshi Tukao ": " control phlegm-fire, sterilization." 2. " Nanning City's medicine will)): " heat clearing away, reduce phlegm, preventing the attack (or recurrence) of malaria, disappear osteodynia.Treating malaria disease, eruptive disease, colicky." 3. " Jiangxi medical herbs ": " clearing away heat-damp and promoting diuresis, hemostasis." 4. " conventional Chinese herbal medicine color atlas ": " clearing away heat and expelling pathogen in the exterior, detumescence.Cure cold fever, thirsty vexed, scabies." 5. Jiangxi " Chinese herbology ": " controls furuncle pyretic toxicity, and Serpentis stings."
Little Sinomenium acutum: nature and flavor are bitter, cold.1. " Hunan medicine will ": " bitter, cold, nontoxic." 2. " Zhejiang conventional medical herbs among the people ": " is bitter, cool." 8. " Chinese herbal medicine is commonly used in Sichuan ": " is bitter, cold." function cures mainly heat-clearing and toxic substances removing, expelling wind and removing dampness.Treating malaria disease, dysentery, rheumatic arthralgia, edema, stranguria with turbid discharge, laryngopharynx swelling and pain, carbuncle, furuncle.1. supplement to the Herbal: " subtertian malaria, phlegmatic cough is unfavorable, swollen cellulitis, and dog poison, leprosy, assorted rash knows master's for main cholera attacked by pestiferous factors, the capable asthenia in sky." 2. " Hunan medicine will ": " reducing swelling and alleviating pain." 3. " Zhejiang conventional medical herbs among the people ": " dispelling, collateral-activating, heat-clearing and toxic substances removing, astringing to arrest bleeding.Treating rheumatic arthritis, hemiplegia, multiple furuncle and phyma, dysentery, venom, uterine prolapse, spitting of blood." 4. " Chinese herbal medicine is commonly used in Sichuan ": " diuresis, analgesic therapy, dispels the wind.Control heart stomachache, mass in abdomen, edema, swelling due to wind, carbuncle malignant boil." 5. Jiangxi " medical herbs handbook ": " clear bottom is damp and hot, controls the inferior portion's eczema." 6. " Fujian Chinese herbal medicine ": ' clearing away heat-fire, inducing diuresis and reducing edema.Control laryngopharynx swelling and pain, damp and hot stranguria with turbid discharge."
Flos Bombacis Malabarici: nature and flavor are sweet is cool.Function cures mainly heat clearing away, dampness removing, removing toxic substances, hemostasis.Control and have loose bowels, dysentery, metrorrhagia, sore, gold creates blood.1. " the SHENGCAO property of medicine is standby to be wanted ": " control dysentery disease, white person is still better." 2. " book on Chinese herbal medicine asks former ": " red person goes bloody dysentery, and white person controls Hakuri, decocts normal drink with military Yi nationality tea." 3. " south of the Five Ridges gather medicinal herbs record ": " relieves summer heat." 4. " Chinese medicine is newly organized ": " diuresis and stomach invigorating." 5. " Nanning City's medicine will ": " remuval of damp and hot.Control metrorrhagia, gold wound." 6. " Guangxi Chinese medicinal herbal ": " dry poison, controls malignant boil." 7. Guangzhou army " conventional Chinese herbal medicine handbook ": " clearing away heat-damp and promoting diuresis, controls enteritis, bacillary dysentery."
Folium glochidionis puberi: nature and flavor " Guangxi Chinese medicinal herbal ": " pained, cool." function cures mainly clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.Control dysentery, jaundice, stranguria with turbid discharge, leukorrhagia, flu, laryngopharynx swelling and pain, carbuncle furuncle, dermatitis rhus, erythra pruritus.1. " Guangxi Chinese medicinal herbal ": " dampness removing, removing blood stasis separate dermatitis rhus, snake venom.Control dermatitis rhus, dysentery, traumatic injury, Serpentis stings poison." 2. " Guangdong Chinese medicine " II: " disappears stagnant, removing dampness, heat clearing away, relaxing muscles and tendons and activating QI and blood in the collateral.Control dysentery, flu, influenza, excessive physical fatigue, Mus, venom."
Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae): nature and flavor toil is flat.1. " Guizhou folk medicine ": " property is put down, and bitter in the mouth is nontoxic." 2. " Traditional Chinese Medicine in Sichuan will ": " is warm in nature, lightly seasoned pungent, nontoxic." 3. " Quanzhou book on Chinese herbal medicine ": " sweet in the mouth is pungent, and property is flat and puckery, nontoxic." returning through " Quanzhou book on Chinese herbal medicine ": " enters liver, kidney, stomach, small intestine meridian." function cures mainly heat clearing away, dampness removing, detumescence, removing toxic substances.Harness the Yellow River subcutaneous ulcer, stranguria with turbid discharge, difficulty and pain in micturition, dysentery, hernia, acute mastitis, scrofula, scalds, knife injury.1. " Guizhou folk medicine ": " heat clearing away.Control knife injury, spit blood, stranguria with turbid discharge, infertile." 2. " Traditional Chinese Medicine in Sichuan will ": " control acute mastitis and puerperal swelling of the breast." 3. " Quanzhou book on Chinese herbal medicine ": " heat-clearing and toxic substances removing, diuresis.Control jaundice due to damp-heat, dysuria, regurgitation is dysphagic, hernia." 4. " the practical Chinese herbal medicine in Guangxi newly selects ": " controls cough due to lung-heat, centipete bite, burn, infantile malnutrition, tuberculous lymphadenitis."
Radix Serissae: nature and flavor toil; Cool; Nontoxic.Return through liver; Spleen channel.Function cures mainly dispels the wind; Dampness removing; Heat clearing away; Removing toxic substances.Main flu; Icterohepatitis; Oedema due to nephritis; Cough; Laryngalgia; Keratitis; Intestinal is scorching; Dysentery; Lumbago and skelalgia; Hemoptysis; Hematuria; Women's amenorrhea; Leucorrhea; Infantile malnutrition; Infantile convulsion; Acute toothache; Swollen ulcer drug; Traumatic injury.
Herba Rabdosiae Lophanthoidis: nature and flavor are Guangzhou army " conventional Chinese herbal medicine handbook " 1.: " sweetness and bitterness, cool." 2. " conventional Chinese herbal medicine color atlas ": " is bitter, cold." function cures mainly clearing away heat-damp and promoting diuresis, cool the blood dissipate blood stasis.Control acute hepatitis, acute cholecystitis, dysentery, enteritis, the difficulty in urination, traumatic injury congestive edema.1. Guangzhou army " conventional Chinese herbal medicine handbook ": " heat clearing away, dampness removing, jaundice eliminating.Control acute icterohepatitis, acute cholecystitis." 2. " conventional Chinese herbal medicine color atlas ": " liver heat removing function of gallbladder promoting, jaundice eliminating damp eliminating, cool the blood dissipate blood stasis.Control acute hepatitis, traumatic injury congestive edema."
Herba Hyperici Japonici: sweet, the micro-hardship of nature and flavor is cool.Function cures mainly clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, eliminating stasis to stop pain.For hepatitis, early stage liver cirrhosis, appendicitis, eye conjunctivitis, tonsillitis; Furuncle toxic swelling is controlled in external, herpes zoster, venom, traumatic injury.
Herba Swertiae Mileensis: nature and flavor are bitter; Cold in nature.Return through liver; Gallbladder; Urinary bladder channel.Function cures mainly heat-clearing and toxic substances removing; Dampness removing jaundice eliminating.Main jaundice due to damp-heat; The puckery pain of pyretic stranguria; Damp-heat dysentery; Leucorrhea with red and white discharge; Influenza; Malaria is generated heat; Acute gastritis; Acute pharyngolaryngitis; Acute tonsillitis.External can control acute conjunctivitis; Allergic dermatitis.
Rhizoma Chiritae Fimbrisepalae: habitats distribution is born in cheuch cliff humidity place, remote mountains.The ground such as distribution Guangxi.Nature and flavor " the practical Chinese herbal medicine in Guangxi newly selects ": " micro-hardship, cool, nontoxic." 1. function cures mainly " register planted by Guangxi medicine ": " interior cough-relieving, treats for stomachache, dysentery, infant malnutrition.Externally used detumescence pain relieving, synthetism, controls traumatic injury." 2. " the practical Chinese herbal medicine in Guangxi newly selects ": " strengthening the spleen to promote digestion, removing damp-heat.Control infant malnutrition, hepatitis."
Herba seu Fructus Physalis Minimae: nature and flavor " Traditional Chinese Medicine in Sichuan will ": " cold in nature, bitter in the mouth is nontoxic." function cures mainly eliminating dampness by diuresis, parasite killing. subcutaneous ulcer of harnessing the Yellow River, dysuria, chronic cough and asthma, infantile malnutrition, scrofula, epidemic blisters, eczema.1. " classify herbal ": " removing toxic substances parasite killing, leaf controls epidemic blisters." 2. " Tian Bao book on Chinese herbal medicine ": " controls children's's tympanites, infantile malnutrition." 3. " Traditional Chinese Medicine in Sichuan will ": " diuresis, disappear mass beside the umbilicus, steaming consumptive fever of boning.To harness the Yellow River subcutaneous ulcer, dysuria, chronic cough dyspnea with rapid respiration; Outer painting children's's impetigo and skin herpes simplex.Alone fruit effect is better." 4. Guangzhou army " conventional Chinese herbal medicine handbook ": " cold, fever, laryngopharynx swelling and pain; Acute bronchitis; Eczema toxic swelling."
Asparagus: nature and flavor are micro-sweet; Property is put down.Function cures mainly clearing away heat-damp and promoting diuresis; Blood circulation promoting and dispersing pathogen accumulation.Main hepatitis; Psoriasis; Hyperlipemia; Lymphosarcoma; Bladder cancer; Breast carcinoma; Skin carcinoma.
Herba lagopsis supinae: nature and flavor are pungent; Micro-hardship; Cold in nature.Gui Jing returns Liver Channel.Function cures mainly nourshing blood and promoting blood circulation; Clearing away heat-damp and promoting diuresis.Main menoxenia; The stagnant stomachache of the stasis of blood in puerperal; Blood deficiency is dizzy; It is unsuccessful partly to penetrate; Traumatic injury; Edema; Dysuria; Conjunctival congestion and swelling pain; Carbuncle sore; Chilblain; Toothache; Erythra pruritus.
Herba Viviae Sativae: nature and flavor are sweet pungent, cold.1. supplement to the Herbal: " sweet in the mouth, cold, nontoxic." 2. " product remittance essence is wanted ": " sweet in the mouth, temper, nontoxic." 3. " vegetation is side just ": " is pungent, flat." function cures mainly clearing away heat-damp and promoting diuresis, and blood and dissolving stasis.To harness the Yellow River subcutaneous ulcer, edema, malaria, epistaxis, cardiopalmus, nocturnal emission, menoxenia.1. supplement to the Herbal: " in adjusting, sharp intestine and small intestine." 2. " Haiyao Bencao, Oversea Materia Medica ": " main dredging water passages, lower edema, profit large intestine." 3. " product remittance essence is wanted ": " QI invigorating, profit flesh, clearly god, Qiang Zhi." 4. " vegetation is side just ": " invigorates blood circulation, removing blood stasis, hemostasis, granulation promoting.Control five jaundice to swell, sharp dirty heat.Preventing the attack (or recurrence) of malaria, flat stomach, improve visual and auditory acuity." 5. " Traditional Chinese Medicine in Sichuan will ": " hemopoietic.Control emission due to deficiency of the kidney, lumbago, damp and hot general edema with yellowish skin."
Herba Silybi mariani: pharmacological action silymarin, has another name called Xi Maliling, has the effect protecting the liver and treat hepatopathy, can resist liver toxicity, and has the effect of anti-x-light ray, does not have toxicity, even if long-term taking also has no adverse reaction.This composition Japan synthesizes.Nature and flavor are bitter; Cool in nature.Function cures mainly clearing away heat-damp and promoting diuresis; Depressed liver-energy dispersing and function of gallbladder promoting.Main chronic hepatitis; Liver cirrhosis fatty liver; Cholelithiasis; Cholangitis.
Herba Abutili: the common roadside of habitats distribution, between wasteland and field.China is not except Qinghai-Tibet Platean is produced, and other various places are all produced, and also there is cultivation various places, northeast.Chemical analysis leaf is containing globulariacitrin (rutin).Nature and flavor are bitter; Flat.Return through spleen; Stomach warp.Function cures mainly clearing away heat-damp and promoting diuresis; Removing toxic substances is had one's ideas straightened out.Main dysentery; Otitis media; Tinnitus; Deaf; Orchitis; Suppurative tonsillitis; Swollen ulcer drug.
Herba Salviae Chinensis: nature and flavor are pungent; Bitter; Cold nature.Gui Jing returns liver; Spleen channel.Function cures mainly blood circulation promoting and blood stasis dispelling; Clearing away heat-damp and promoting diuresis; Mass dissipating and swelling eliminating.Main menoxenia; Dysmenorrhea; Amenorrhea; Metrorrhagia, has blood in stool; Jaundice due to damp-heat; Hot toxic-heat and blood stasis; Drench pain; Leukorrhagia; Rheumatic ostalgia; Scrofula; Skin ulcer swells; Acute mastitis; Herpes zoster; Leprosy; Traumatic injury wound is swollen.
Radix Bauhiniae Hupehanae: the phytohemagglutinin having specific anti-N in pharmacological action seed.Nature and flavor are pained; Flat; Nontoxic.Return through kidney; Large intestine channel.It is astringent or styptic treatment for spontaneous sweating that function cures mainly convergence, removing toxic substances dehumidifying.Main cough spitting of blood, spit blood, have blood in stool, the enuresis, frequent micturition, leucorrhea, uterine prolapse, dysentery, arthralgia pain, hernia, painful and swollen testis, eczema, furuncle swells and ache.
Herba Kyllingae: be Cyperaceae Kyllinga plant short leaf Herba Kyllingae Kyllinga brevifolia Rottb., with all herbal medicine.The whole year can adopt, and cleans, dries use.Nature and flavor are pungent, flat.Function cures mainly dispelling wind to relieve the exterior syndrome, clearing away heat-damp and promoting diuresis, relieving cough and resolving phlegm, removing blood stasis to reduce swelling.For Common Cold, bronchitis, pertussis, malaria, dysentery, hepatitis, chyluria, traumatic injury, rheumatic arthritis; Venom is controlled in external, skin pruritus, furuncle and phyma.
Fructus Elaeagni Umbellatae: nature and flavor are bitter is cool." Hunan medicine will ": " bitter puckery ".Cure mainly clearing away heat-damp and promoting diuresis, hemostasis.Control cough, have loose bowels, dysentery, gonorrhea, metrorrhagia and leukorrhagia.1. " Zhiwu Mingshi Tukao ": " control larynx heat." 2. " Jiangsu medical material will ": " restrains, hemostasis, antidiarrheal." 3. " Hunan medicine will ": " spleen reinforcing, expelling cold and relieving exterior syndrome, pathogenic wind expelling damp eliminating, activating blood circulation, diuresis." 4. " catalogue planted by Guizhou medicine ": " root: control measles.Leaf: control furuncle."
Carapax Trionycis: nature and flavor are salty is flat.1. " herbal classic ": " salty in the mouth is flat." 2. " not Lu ": " be nontoxic." 3. " Bencao Congxin ": " is salty, cold." return through entering liver, spleen channel.1. " detailed outline ": " cloudy Liver Channel of fainting." 2. " Thunder God concocts property of medicine solution ": " enters liver, spleen two warp." 3. " book on Chinese herbal medicine converges and says ": " enters sufficient faint the moon, shaoyin channel." function cures mainly replenishing YIN and removing heat, suppressing the hyperactive liver to relieve the wind syndrome, hard masses softening and resolving.Control consumptive fever hectic fever due to YIN-deficiency, stirring of wind due to deficiency of YIN, malaria with general debility malaria with splenomegaly, lump in the abdomen mass beside the umbilicus, amenorrhea menometrorrhagia, pediatric epilepsy scared.1. " herbal classic ": " main trusted subordinate's lump in the abdomen heavily fortified point is long-pending, cold and heat, goes painful abdominal mass, polyp, the erosion of the vulva, hemorrhoid (core), evil meat." 2. " not Lu ": " treats pyrexial malaria, and abdominal mass due to blood stasis, lumbago, children's coerces lower heavily fortified point." 3. " property of medicine opinion ": " main dyspepsia, disease block, mass beside the umbilicus gas, cold abdominal mass, labor are thin, the therapeutic method to keep the adverse QI flowing downwards, and except bone heat, consumptive fever between joint, is solidly jammed.Control married woman to leak down multicolored weakness and emaciation person." 4. " Japan hanako materia medica ": " gas of dehematizing, broken crux, stagnant blood, induced abortion, the skin ulcer that disappears swells and flutters damage blood stasis, malaria, acute appendicitis." 5. " Amplification on Materia Medica addendum ": " nourishing YIN QI invigorating." 6. " Elementary Medicine ": " main malaria with general debility, old malaria, woman's amenorrhea, infant dysentery." 7. " detailed outline ": " except old malaria malaria with splenomegaly, insidious stomachache, recurrence caused by overexertion, relapse due to improper diet, speckle cellulitis restlessness and dyspnea, married woman have difficult labour, puerperal prolapse of the uterus, husband's erosion of vulva, stranguria caused by urinary stone; Hold back routed carbuncle." 8. " Jiangxi Chinese medicine ": " controls osteomalacia."
Cornu procaprae gutturosae: nature and flavor are salty; Cold in nature.Return through Liver Channel.Function cures mainly suppressing the hyperactive liver to relieve the wind syndrome; Heat-clearing and toxic substances removing.Main epidemic febrile disease unconsciousness due to high fever convulsion is fainted; Infantile common cold generates heat; Infantile convulsion; Apoplexy; Optic atrophy.
Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Herba Selaginellae Moellendorfii 10-25 weight portion, Herba Pteridis Multifidae 12-24 weight portion, Herba Kalimeridis 10-20 weight portion, Radix Symplocoris chinensis 1-3 weight portion, little Sinomenium acutum 1-3 weight portion, Flos Bombacis Malabarici 10-25 weight portion, Folium glochidionis puberi 1-3 weight portion, Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae) 12-26 weight portion, Radix Serissae 13-28 weight portion, Herba Rabdosiae Lophanthoidis 10-20 weight portion, Herba Hyperici Japonici 14-28 weight portion, Herba Swertiae Mileensis 10-20 weight portion, Rhizoma Chiritae Fimbrisepalae 13-24 weight portion, Herba seu Fructus Physalis Minimae 10-20 weight portion, asparagus 15-20 weight portion, Herba lagopsis supinae 13-26 weight portion, Herba Viviae Sativae 10-20 weight portion, Herba Silybi mariani 14-29 weight portion, Herba Abutili 12-20 weight portion, Herba Salviae Chinensis 10-20 weight portion, Radix Bauhiniae Hupehanae 10-23 weight portion, Herba Kyllingae 14-26 weight portion, Fructus Elaeagni Umbellatae 15-29 weight portion, Carapax Trionycis 10-20 weight portion and Cornu procaprae gutturosae 10-18 weight portion.
Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Herba Selaginellae Moellendorfii 20-25 weight portion, Herba Pteridis Multifidae 20-24 weight portion, Herba Kalimeridis 15-20 weight portion, Radix Symplocoris chinensis 2-3 weight portion, little Sinomenium acutum 2-3 weight portion, Flos Bombacis Malabarici 20-25 weight portion, Folium glochidionis puberi 2-3 weight portion, Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae) 20-26 weight portion, Radix Serissae 20-28 weight portion, Herba Rabdosiae Lophanthoidis 15-20 weight portion, Herba Hyperici Japonici 20-28 weight portion, Herba Swertiae Mileensis 15-20 weight portion, Rhizoma Chiritae Fimbrisepalae 20-24 weight portion, Herba seu Fructus Physalis Minimae 15-20 weight portion, asparagus 18-20 weight portion, Herba lagopsis supinae 20-26 weight portion, Herba Viviae Sativae 15-20 weight portion, Herba Silybi mariani 20-29 weight portion, Herba Abutili 18-20 weight portion, Herba Salviae Chinensis 15-20 weight portion, Radix Bauhiniae Hupehanae 20-23 weight portion, Herba Kyllingae 20-26 weight portion, Fructus Elaeagni Umbellatae 20-29 weight portion, Carapax Trionycis 15-20 weight portion and Cornu procaprae gutturosae 15-18 weight portion.
Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Herba Selaginellae Moellendorfii 10 weight portion, Herba Pteridis Multifidae 12 weight portion, Herba Kalimeridis 10 weight portion, Radix Symplocoris chinensis 1 weight portion, little Sinomenium acutum 1 weight portion, Flos Bombacis Malabarici 10 weight portion, Folium glochidionis puberi 1 weight portion, Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae) 12 weight portion, Radix Serissae 13 weight portion, Herba Rabdosiae Lophanthoidis 10 weight portion, Herba Hyperici Japonici 14 weight portion, Herba Swertiae Mileensis 10 weight portion, Rhizoma Chiritae Fimbrisepalae 13 weight portion, Herba seu Fructus Physalis Minimae 10 weight portion, asparagus 15 weight portion, Herba lagopsis supinae 13 weight portion, Herba Viviae Sativae 10 weight portion, Herba Silybi mariani 14 weight portion, Herba Abutili 12 weight portion, Herba Salviae Chinensis 1-20 weight portion, Radix Bauhiniae Hupehanae 10 weight portion, Herba Kyllingae 14 weight portion, Fructus Elaeagni Umbellatae 15 weight portion, Carapax Trionycis 10 weight portion and Cornu procaprae gutturosae 10 weight portion.
Wherein, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Herba Selaginellae Moellendorfii 25 weight portion, Herba Pteridis Multifidae 24 weight portion, Herba Kalimeridis 20 weight portion, Radix Symplocoris chinensis 3 weight portion, little Sinomenium acutum 3 weight portion, Flos Bombacis Malabarici 25 weight portion, Folium glochidionis puberi 3 weight portion, Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae) 26 weight portion, Radix Serissae 28 weight portion, Herba Rabdosiae Lophanthoidis 20 weight portion, Herba Hyperici Japonici 28 weight portion, Herba Swertiae Mileensis 20 weight portion, Rhizoma Chiritae Fimbrisepalae 24 weight portion, Herba seu Fructus Physalis Minimae 20 weight portion, asparagus 20 weight portion, Herba lagopsis supinae 26 weight portion, Herba Viviae Sativae 20 weight portion, Herba Silybi mariani 29 weight portion, Herba Abutili 20 weight portion, Herba Salviae Chinensis 20 weight portion, Radix Bauhiniae Hupehanae 23 weight portion, Herba Kyllingae 26 weight portion, Fructus Elaeagni Umbellatae 29 weight portion, Carapax Trionycis 20 weight portion and Cornu procaprae gutturosae 18 weight portion.
For solving the problems of the technologies described above, present invention also offers a kind of preparation method of described Chinese medicine composition, wherein, when the dosage form of described Chinese medicine composition is granule, its preparation method is:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 3 ~ 6 times, mixture is the ethanol of 80% ~ 90%, be heated to boiling reflux 2 ~ 4 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 55 ~ 65 DEG C subsequently under vacuum 0.07 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 150 ~ 165 DEG C of spray dryer, leaving air temp 70 ~ 75 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.5 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 45 ~ 50 DEG C of dryings, obtains granule.
When the dosage form of described Chinese medicine composition is capsule and dripping agent, its preparation method is:
The first step, by Herba Selaginellae Moellendorfii, Herba Pteridis Multifidae and Herba Kalimeridis mixing, add relative to mixture 2 times ~ 4 times amount determining alcohol be 75% ~ 85% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 4 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 60 DEG C of relative densities is the mastic of 1.20 ~ 1.22, for subsequent use;
Second step, is mixed in proportion described for residue raw medicinal material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.23 ~ 1.25;
3rd step, the mastic mixing that the first step, second step are obtained, 65 DEG C ~ 75 DEG C reduced vacuum dryings, get dry extract powder, pulverized by described dried cream powder, filters obtain fine powder through 90-120 order;
4th step, adds the vegetable oil of 1-2 times amount, mix homogeneously by the fine powder that the 3rd step obtains, then load in ' Yanming ' capsules for clearing, become capsule and dripping agent.
The dosage form of described Chinese medicine composition is: sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, capsule and dripping agent, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster and syrup.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 granule
Herba Selaginellae Moellendorfii 10g, Herba Pteridis Multifidae 12g, Herba Kalimeridis 10g, Radix Symplocoris chinensis 1g, little Sinomenium acutum 1g, Flos Bombacis Malabarici 10g, Folium glochidionis puberi 1g, Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae) 12g, Radix Serissae 13g, Herba Rabdosiae Lophanthoidis 10g, Herba Hyperici Japonici 14g, Herba Swertiae Mileensis 10g, Rhizoma Chiritae Fimbrisepalae 13g, Herba seu Fructus Physalis Minimae 10g, asparagus 15g, Herba lagopsis supinae 13g, Herba Viviae Sativae 10g, Herba Silybi mariani 14g, Herba Abutili 12g, Herba Salviae Chinensis 1-20g, Radix Bauhiniae Hupehanae 10g, Herba Kyllingae 14g, Fructus Elaeagni Umbellatae 15g, Carapax Trionycis 10g and Cornu procaprae gutturosae 10g.
Its preparation method is:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 times, mixture is the ethanol of 80%, be heated to boiling reflux 4 hours, filter, adopt percolation with the speed of 1ml per minute slowly percolation, collect percolate, when being evaporated to 55 DEG C subsequently under vacuum 0.07Mpa, relative density is the mastic of 1.04, spraying dry, the inlet temperature 165 DEG C of spray dryer, leaving air temp 75 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 times and 0.1 times in the dried cream powder obtained, makes granule, in 50 DEG C of dryings, obtains granule.
Embodiment 2 capsule and dripping agent
Herba Selaginellae Moellendorfii 25g, Herba Pteridis Multifidae 24g, Herba Kalimeridis 20g, Radix Symplocoris chinensis 3g, little Sinomenium acutum 3g, Flos Bombacis Malabarici 25g, Folium glochidionis puberi 3g, Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae) 26g, Radix Serissae 28g, Herba Rabdosiae Lophanthoidis 20g, Herba Hyperici Japonici 28g, Herba Swertiae Mileensis 20g, Rhizoma Chiritae Fimbrisepalae 24g, Herba seu Fructus Physalis Minimae 20g, asparagus 20g, Herba lagopsis supinae 26g, Herba Viviae Sativae 20g, Herba Silybi mariani 29g, Herba Abutili 20g, Herba Salviae Chinensis 20g, Radix Bauhiniae Hupehanae 23g, Herba Kyllingae 26g, Fructus Elaeagni Umbellatae 29g, Carapax Trionycis 20g and Cornu procaprae gutturosae 18g.
Its preparation method is:
The first step, by Herba Selaginellae Moellendorfii, Herba Pteridis Multifidae and Herba Kalimeridis mixing, add relative to mixture 2 times amount determining alcohol be 85% alcohol reflux 2 times, each 2 hours, filter, filtrate merges, and reclaim ethanol, being concentrated into 60 DEG C of relative densities is the mastic of 1.20, for subsequent use;
Second step, is mixed in proportion described for residue raw medicinal material, adds relative to mixture 3 times of water gagings, boils 2 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.23;
3rd step, the mastic mixing that the first step, second step are obtained, 65 DEG C of reduced vacuum dryings, get dry extract powder, pulverized by described dried cream powder, filters obtain fine powder through 90 orders;
4th step, adds the vegetable oil of 1 times amount, mix homogeneously by the fine powder that the 3rd step obtains, then load in ' Yanming ' capsules for clearing, become capsule and dripping agent.
Embodiment 3 decoction
Herba Selaginellae Moellendorfii 15g, Herba Pteridis Multifidae 14g, Herba Kalimeridis 15g, Radix Symplocoris chinensis 2g, little Sinomenium acutum 2g, Flos Bombacis Malabarici 15g, Folium glochidionis puberi 1g, Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae) 24g, Radix Serissae 18g, Herba Rabdosiae Lophanthoidis 10g, Herba Hyperici Japonici 28g, Herba Swertiae Mileensis 20g, Rhizoma Chiritae Fimbrisepalae 24g, Herba seu Fructus Physalis Minimae 20g, asparagus 15g, Herba lagopsis supinae 13g, Herba Viviae Sativae 10g, Herba Silybi mariani 14g, Herba Abutili 12g, Herba Salviae Chinensis 20g, Radix Bauhiniae Hupehanae 13g, Herba Kyllingae 16g, Fructus Elaeagni Umbellatae 29g, Carapax Trionycis 20g and Cornu procaprae gutturosae 18g.
Its preparation method is:
Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 3cm, soak 4 hours;
Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 30 minutes dosage to medicinal liquid be slowly 120ml, filters, obtain filtrate a, for subsequent use;
Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2cm, soaks 4 hours;
Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 30 minutes dosage to medicinal liquid be slowly 100ml, filters, obtain filtrate b, filtrate a and filtrate b is mixed to obtain decoction.
Toxicity test
Acute toxicity test
Application NIH mice 30, SPF level, male and female half and half, body weight 18 ~ 22g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 15, i.e. matched group and administration group, fasting 12 hours before experiment; Granule prepared by embodiments of the invention 1 is dissolved in water, (concentration is 7.2g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 36g crude drug/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>36g crude drug/kg of the present invention, every day, maximum dosage-feeding was 72g crude drug/kg/ day.Chinese medicine clinical application amount of the present invention be 5g crude drug/day/people, adult body weight in 60KG, average dosage is 0.083g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 20g) oral administration gavage Chinese medicine of the present invention is 867 times of quantity.Therefore Chinese medicine composition acute toxicity of the present invention is low, clinical drug safety.
Cumulative toxicity test
Test method: select 20 healthy mices, female, each 10 of hero, with the decoction of the embodiment of the present invention 3 for object, dose design is first phase in every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.2LD50,0.3LD 50,0.4LD50, the LD 50 that is female, male mice of this sample be 6000m part/k part BW (five dosage is 600,900,1200,1800,2400m part/k part BW).Within every 5 days, weigh once, adjustment dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose to tested material after 20 days, female, buck all occurs without death condition.Illustrate that Chinese medicine composition of the present invention does not have cumulative toxicity, clinical medical safety.
 
Clinical trial
Case selection: during selecting in May ,-2013 in May, 2012, retention and fumigation of damp-heat inside the body type jaundice neonate totally 400 examples of my institute's diagnosis and treatment.Wherein, man 202 example, female 198 example, 90 examples of 0-10 age in days, 180 examples of 11-20 age in days, more than 21 ages in days 130 examples.Have 100 examples in retention and fumigation of damp-heat inside the body type jaundice sick time 1 week, thoughtful 3 weeks of sick time 1 have 120 examples, sick time more than 3 weeks 180 routine, be divided into two groups at random, treat one group, treat two groups, treat three groups and matched group each 100 routine.Four groups of infants comparing difference not statistically significant in age, sex, state of an illness weight, has comparability, and according to the weight out-patient treatment of the state of an illness.
Diagnostic criteria:
1. jaundice occurs that early (being born in 24 hours), development is fast, obviously yellow, again occurs after can disappearing.Or jaundice occurs late, persistent, the common enlargement of liver spleen, tired mind, hesitating to suck, stool or in canescence.
2. appearance yellowing of the skin, bright and lustrous as Fructus Citri tangerinae, sob is loud, hesitating to suck, thirsty dry lip, or has heating, constipation, and urine is deep yellow, red tongue, yellow and greasy fur.
With reference to project:
1. serum bilirubin is greater than 205 μm of ol/L.Icteric index increases.2. the urine bilirubin positive or urobilinogen test positive or negative.3. abnormal liver function.4. hepatitis syndrome should do the inspection of Australia antigen system.
Therapeutic Method:
Treat one group: this group 100 example, use the granule of the embodiment of the present invention 1 to treat.Each 0.5 bag (5g/ bag), every day twice 2 days is a course for the treatment of, and 2 courses for the treatment of are carried out in treatment.Follow up a case by regular visits to one month.
Treat one group: this group 100 example, use the capsule and dripping agent of the embodiment of the present invention 2 to treat.Each 1, every day twice 2 days is a course for the treatment of, and 2 courses for the treatment of are carried out in treatment.Follow up a case by regular visits to one month.
Treat one group: this group 100 example, use the decoction of the embodiment of the present invention 3 to treat.Each 5ml, every day twice 2 days is a course for the treatment of, and 2 courses for the treatment of are carried out in treatment.Follow up a case by regular visits to one month.
Matched group: matched group 100 people, uses Si Liankang treatment.Baby 2 times on the one in six months, one time 1, within 2 days, be a course for the treatment of, treatment carry out 2 courses for the treatment of.Follow up a case by regular visits to one month.
The standard of curative effect evaluation:
1. fully recover: jaundice disappears, and liver function test is normal.
2. take a turn for the better: jaundice obviously alleviates, liver function etc. check recovers normal not yet completely.
3. invalid: jaundice does not disappear or deepens, and symptom is not improved, and liver function test is abnormal.
Therapeutic outcome
Table 1 is the efficacy result contrast for the treatment of by Chinese herbs group and western medicine group:
Group Number of cases Recovery from illness Take a turn for the better Invalid Cure rate Improvement rate Total effective rate (recovery from illness and improvement)
Treat one group 100 97 3 0 97% 3% 100%
Treat two groups 100 98 2 0 98% 2% 100%
Treat three groups 100 97 3 0 97% 3% 100%
Matched group 100 75 5 20 75% 5% 80%
As can be seen from Table 1, recovery from illness number and the improvement number of three treatment groups are all higher than western medicine group, therefore, can learn, Chinese medicine composition of the present invention, and in the newborn jaundice for the treatment of retention and fumigation of damp-heat inside the body type, good effect, determined curative effect, effective percentage is high.
Table 2 is the recovery from illness for the treatment of by Chinese herbs group and western medicine group and the time contrast of improvement:
Group Number of cases 1st course for the treatment of 2nd course for the treatment of
Treat one group 100 80（80%) 20(20%)
Treat two groups 100 78(78%) 22(22%)
Treat three groups 100 76(76%) 24(24%)
Matched group 80 30(37.5%) 50(62.5%)
As can be seen from Table 2, the recovery from illness of three treatment groups is compared with western medicine group with improvement, and the short time just can occur curative effect.Can learn, Chinese medicine composition of the present invention, in treatment neonate retention and fumigation of damp-heat inside the body type jaundice, curative effect is fast, and rapid-action, treatment time is shorter.
Table 3 is the treatment forward backward averaging body weight growth pattern for the treatment of group and matched group
Group Average weight before treatment Average weight after treatment Body weight daily growth amount
Treat one group 3.48kg 3.72kg 0.06kg/d
Treat two groups 3.47kg 3.72kg 0.0625kg/d
Treat three groups 3.49kg 3.74kg 0.0625kg/d
Matched group 3.47kg 3.61kg 0.035kg/d
As can be seen from Table 3, the medicine of three treatment groups is in treatment retention and fumigation of damp-heat inside the body type neonatal jaundice, and not only effectively, its neonatal growth is not also greatly affected, and body weight daily growth amount is higher than western medicine group in treatment.It can thus be appreciated that Chinese medicine composition of the present invention, is well grown while treatment retention and fumigation of damp-heat inside the body type neonatal jaundice.
In sum, Chinese medicine composition of the present invention, have good effect, determined curative effect in treatment neonate warm accumulation type jaundice of trembling with fear, curative effect is fast, rapid-action feature.Moreover, not there is toxicity, be free from side effects, also do not affect its neonatal growth.
, there is jaundice in second day in model case: certain children's hospital accepts the full-term normal delivery boy baby of diagnosis and treatment, body weight 3200g, Pure breast feeding, and continues not eliminate for two weeks.Symptoms is appearance yellowing of the skin, and bright and lustrous as Fructus Citri tangerinae, sob is loud, hesitating to suck, thirsty dry lip, and urine is deep yellow, red tongue.After measured, retention and fumigation of damp-heat inside the body type neonatal jaundice is diagnosed as.The capsule and dripping agent of the embodiment of the present invention 2 is used to treat.Each 1, every day twice 2 days is a course for the treatment of, in therapeutic process, does not occur other untoward reaction, and 2 courses for the treatment of are carried out in treatment, recovery from illness.After treatment, body weight is 3400g.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. treat the Chinese medicine composition of neonate retention and fumigation of damp-heat inside the body type jaundice for one kind, it is characterized in that, comprise following raw medicinal material: Herba Selaginellae Moellendorfii, Herba Pteridis Multifidae, Herba Kalimeridis, Radix Symplocoris chinensis, little Sinomenium acutum, Flos Bombacis Malabarici, Folium glochidionis puberi, Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae), Radix Serissae, Herba Rabdosiae Lophanthoidis, Herba Hyperici Japonici, Herba Swertiae Mileensis, Rhizoma Chiritae Fimbrisepalae, Herba seu Fructus Physalis Minimae, asparagus, Herba lagopsis supinae, Herba Viviae Sativae, Herba Silybi mariani, Herba Abutili, Herba Salviae Chinensis, Radix Bauhiniae Hupehanae, Herba Kyllingae, Fructus Elaeagni Umbellatae, Carapax Trionycis and Cornu procaprae gutturosae.
2. Chinese medicine composition as claimed in claim 1, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Herba Selaginellae Moellendorfii 10-25 weight portion, Herba Pteridis Multifidae 12-24 weight portion, Herba Kalimeridis 10-20 weight portion, Radix Symplocoris chinensis 1-3 weight portion, little Sinomenium acutum 1-3 weight portion, Flos Bombacis Malabarici 10-25 weight portion, Folium glochidionis puberi 1-3 weight portion, Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae) 12-26 weight portion, Radix Serissae 13-28 weight portion, Herba Rabdosiae Lophanthoidis 10-20 weight portion, Herba Hyperici Japonici 14-28 weight portion, Herba Swertiae Mileensis 10-20 weight portion, Rhizoma Chiritae Fimbrisepalae 13-24 weight portion, Herba seu Fructus Physalis Minimae 10-20 weight portion, asparagus 15-20 weight portion, Herba lagopsis supinae 13-26 weight portion, Herba Viviae Sativae 10-20 weight portion, Herba Silybi mariani 14-29 weight portion, Herba Abutili 12-20 weight portion, Herba Salviae Chinensis 10-20 weight portion, Radix Bauhiniae Hupehanae 10-23 weight portion, Herba Kyllingae 14-26 weight portion, Fructus Elaeagni Umbellatae 15-29 weight portion, Carapax Trionycis 10-20 weight portion and Cornu procaprae gutturosae 10-18 weight portion.
3. Chinese medicine composition as claimed in claim 1 or 2, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Herba Selaginellae Moellendorfii 20-25 weight portion, Herba Pteridis Multifidae 20-24 weight portion, Herba Kalimeridis 15-20 weight portion, Radix Symplocoris chinensis 2-3 weight portion, little Sinomenium acutum 2-3 weight portion, Flos Bombacis Malabarici 20-25 weight portion, Folium glochidionis puberi 2-3 weight portion, Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae) 20-26 weight portion, Radix Serissae 20-28 weight portion, Herba Rabdosiae Lophanthoidis 15-20 weight portion, Herba Hyperici Japonici 20-28 weight portion, Herba Swertiae Mileensis 15-20 weight portion, Rhizoma Chiritae Fimbrisepalae 20-24 weight portion, Herba seu Fructus Physalis Minimae 15-20 weight portion, asparagus 18-20 weight portion, Herba lagopsis supinae 20-26 weight portion, Herba Viviae Sativae 15-20 weight portion, Herba Silybi mariani 20-29 weight portion, Herba Abutili 18-20 weight portion, Herba Salviae Chinensis 15-20 weight portion, Radix Bauhiniae Hupehanae 20-23 weight portion, Herba Kyllingae 20-26 weight portion, Fructus Elaeagni Umbellatae 20-29 weight portion, Carapax Trionycis 15-20 weight portion and Cornu procaprae gutturosae 15-18 weight portion.
4. the Chinese medicine composition as described in any one of claims 1 to 3, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Herba Selaginellae Moellendorfii 10 weight portion, Herba Pteridis Multifidae 12 weight portion, Herba Kalimeridis 10 weight portion, Radix Symplocoris chinensis 1 weight portion, little Sinomenium acutum 1 weight portion, Flos Bombacis Malabarici 10 weight portion, Folium glochidionis puberi 1 weight portion, Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae) 12 weight portion, Radix Serissae 13 weight portion, Herba Rabdosiae Lophanthoidis 10 weight portion, Herba Hyperici Japonici 14 weight portion, Herba Swertiae Mileensis 10 weight portion, Rhizoma Chiritae Fimbrisepalae 13 weight portion, Herba seu Fructus Physalis Minimae 10 weight portion, asparagus 15 weight portion, Herba lagopsis supinae 13 weight portion, Herba Viviae Sativae 10 weight portion, Herba Silybi mariani 14 weight portion, Herba Abutili 12 weight portion, Herba Salviae Chinensis 1-20 weight portion, Radix Bauhiniae Hupehanae 10 weight portion, Herba Kyllingae 14 weight portion, Fructus Elaeagni Umbellatae 15 weight portion, Carapax Trionycis 10 weight portion and Cornu procaprae gutturosae 10 weight portion.
5. the Chinese medicine composition as described in any one of Claims 1-4, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of each raw medicinal material is: Herba Selaginellae Moellendorfii 25 weight portion, Herba Pteridis Multifidae 24 weight portion, Herba Kalimeridis 20 weight portion, Radix Symplocoris chinensis 3 weight portion, little Sinomenium acutum 3 weight portion, Flos Bombacis Malabarici 25 weight portion, Folium glochidionis puberi 3 weight portion, Rhizoma Nephrolepis Cordifoliae (Herba Nephrolepis Cordifoliae) 26 weight portion, Radix Serissae 28 weight portion, Herba Rabdosiae Lophanthoidis 20 weight portion, Herba Hyperici Japonici 28 weight portion, Herba Swertiae Mileensis 20 weight portion, Rhizoma Chiritae Fimbrisepalae 24 weight portion, Herba seu Fructus Physalis Minimae 20 weight portion, asparagus 20 weight portion, Herba lagopsis supinae 26 weight portion, Herba Viviae Sativae 20 weight portion, Herba Silybi mariani 29 weight portion, Herba Abutili 20 weight portion, Herba Salviae Chinensis 20 weight portion, Radix Bauhiniae Hupehanae 23 weight portion, Herba Kyllingae 26 weight portion, Fructus Elaeagni Umbellatae 29 weight portion, Carapax Trionycis 20 weight portion and Cornu procaprae gutturosae 18 weight portion.
6. the Chinese medicine composition as described in any one of claim 1 to 5, is characterized in that, when the dosage form of described Chinese medicine composition is granule, its preparation method is:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 3 ~ 6 times, mixture is the ethanol of 80% ~ 90%, be heated to boiling reflux 2 ~ 4 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 55 ~ 65 DEG C subsequently under vacuum 0.07 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 150 ~ 165 DEG C of spray dryer, leaving air temp 70 ~ 75 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.5 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 45 ~ 50 DEG C of dryings, obtains granule.
7. the Chinese medicine composition as described in any one of claim 1 to 5, is characterized in that, when the dosage form of described Chinese medicine composition is capsule and dripping agent, its preparation method is:
The first step, by Herba Selaginellae Moellendorfii, Herba Pteridis Multifidae and Herba Kalimeridis mixing, add relative to mixture 2 times ~ 4 times amount determining alcohol be 75% ~ 85% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 4 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 60 DEG C of relative densities is the mastic of 1.20 ~ 1.22, for subsequent use;
Second step, is mixed in proportion described for residue raw medicinal material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.23 ~ 1.25;
3rd step, the mastic mixing that the first step, second step are obtained, 65 DEG C ~ 75 DEG C reduced vacuum dryings, get dry extract powder, pulverized by described dried cream powder, filters obtain fine powder through 90-120 order;
4th step, adds the vegetable oil of 1-2 times amount, mix homogeneously by the fine powder that the 3rd step obtains, then load in ' Yanming ' capsules for clearing, become capsule and dripping agent.
8. a preparation method for the Chinese medicine composition described in any one of claim 1 to 5, is characterized in that, when the dosage form of described Chinese medicine composition is granule, its preparation method is:
Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 3 ~ 6 times, mixture is the ethanol of 80% ~ 90%, be heated to boiling reflux 2 ~ 4 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 55 ~ 65 DEG C subsequently under vacuum 0.07 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 150 ~ 165 DEG C of spray dryer, leaving air temp 70 ~ 75 DEG C, be ground into powder subsequently, make dried cream powder;
Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.5 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 45 ~ 50 DEG C of dryings, obtains granule.
9. a preparation method for the Chinese medicine composition described in any one of claim 1 to 5, is characterized in that, when the dosage form of described Chinese medicine composition is capsule and dripping agent, its preparation method is:
The first step, by Herba Selaginellae Moellendorfii, Herba Pteridis Multifidae and Herba Kalimeridis mixing, add relative to mixture 2 times ~ 4 times amount determining alcohol be 75% ~ 85% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 4 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 60 DEG C of relative densities is the mastic of 1.20 ~ 1.22, for subsequent use;
Second step, is mixed in proportion described for residue raw medicinal material, adds relative to mixture 3 ~ 5 times of water gagings, boils 2 ~ 4 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.23 ~ 1.25;
3rd step, the mastic mixing that the first step, second step are obtained, 65 DEG C ~ 75 DEG C reduced vacuum dryings, get dry extract powder, pulverized by described dried cream powder, filters obtain fine powder through 90-120 order;
4th step, adds the vegetable oil of 1-2 times amount, mix homogeneously by the fine powder that the 3rd step obtains, then load in ' Yanming ' capsules for clearing, become capsule and dripping agent.
10. the Chinese medicine composition as described in any one of claim 1 to 5, it is characterized in that, the dosage form of described Chinese medicine composition is: sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, capsule and dripping agent, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, suppository, plaster and syrup.
CN201410554482.5A 2014-10-17 2014-10-17 Traditional Chinese medicine composition for treating icterus neonatorum with symptom of retention and fumigation of damp-heat and preparation method thereof Pending CN104306668A (en)

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