CN104958660A - Traditional Chinese medicine for treating liver Qi stagnation type chronic hepatitis B and preparation method for traditional Chinese medicine - Google Patents

Abstract

The invention provides a traditional Chinese medicine for treating liver Qi stagnation type chronic hepatitis B and a preparation method for the traditional Chinese medicine. The traditional Chinese medicine is prepared from the following raw materials: begonia fimbristipula, rhizoma panacis majoris, catharanthus roseus, root of ficus gasparriniana, stem of moupin dutchmanspipe, herb of denseflower bulbophyllum, magnolia officinalis flowers, loquat cores, fiveleaf akebia fruits, hedychium spicatum, mongollian thyme herb, hinn ervtmi root, herb of creeping falsepimpernel, homalocladium platycladum, melastoma dodecandrum roots, pearly maesa, root of kerr treebine, impatiens balsamina, callicarpa longissima and root of Chinese eriosema. The traditional Chinese medicine has the beneficial effects that the traditional Chinese medicine is high in pertinence to the liver Qi stagnation type chronic hepatitis B according to the principle of evidence-based medicine in traditional Chinese medicines, definite in treating effect, quick in response, low in toxic and side effect and low in recurrence rate.

Description

A kind of Chinese medicine and preparation method for the treatment of caused by hepatic stagnation qi stagnation chronic hepatitis B

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to a kind of Chinese medicine and preparation method for the treatment of caused by hepatic stagnation qi stagnation chronic hepatitis B.

Background technology

Hepatitis B is also called serum hepatitis, hepatitis B, is the infectious disease caused by hepatitis B virus (HBV).By blood and body fluid communication, there is chronic carrier state.Because it can be propagated by sexual life, listed in sexually transmitted disease (STD) in the world.Hepatitis B is extensively popular in China, and crowd infection rate is high, and in certain areas, infection rate reaches more than 35%.Hepatitis B diverse clinical manifestations, easily develops into chronic hepatitis and liver cirrhosis, and a few patients can change primary hepatocarcinoma into.Primary treatments is antiviral therapy.

The treatment of hepatitis should according to Clinical types, and etiologic different type takes different remedy measures, and total principle is: suitably to have a rest, adequate nutrition is main, and selectivity uses medicine to be auxiliary, should give up alcohol, prevent overwork and avoid application to damage liver medicine, medication GPRS should be simple unsuitable numerous.Chronic hepatitis mainly comprises antiviral and copies, and improves body's immunity.

Chronic hepatitis B (abbreviation hepatitis B) refers to hepatitis B virus test positive, and the course of disease exceedes half a year or indefinitely and clinical there is chronic hepatitis shower date of the onset.The symptoms such as clinical manifestation is weak, sitophobia, feel sick, abdominal distention, hepatalgia.Hepatomegaly, quality is medium hardness, has light tenderness.State of an illness severe one can with chronic hepatopathy face, spider angioma, liver palm, splenomegaly, and liver function can exception or persistent anomaly.

Treatment chronic viral hepatitis B is a process of adhering to for a long time, and the selection of medicine also plays vital effect in this process.A lot of Chronic Hepatitis B is anxious owing to curing the disease, look at the advertisement of covering the sky and the earth, the ability of differentiating between right and wrong also declines to some extent, look at this that family also good, have the attitude of seeing that medicine is just eaten in arms, do so not only could not reach to cure early and can produce drug resistance and side effect on the contrary, but also further damage can be caused to be unfavorable for the improvement of the state of an illness to liver.The medicine for the treatment of chronic viral hepatitis B is divided into two large classes, and a class is interferon, and a class is nucleoside medicine.Wherein, interferon makes cell produce antiviral protein by cell surface receptor thus suppresses hepatitis B virus duplication to play antiviral effect, and interferon medicine has plain interferon and long-acting interferon.Another kind is nucleoside medicine, and it is a kind of antiviral drugs, and can improve immunity and recover the effect of liver function, this type of medicine has lamivudine, adefovir ester, Sebivo, Entecavir etc.Although these medicines have good antiviral effect to treatment chronic viral hepatitis B, if pathological changes or drug resistance will occur long-term taking, also many difficulties can be increased to later treatment.At present, also there is a large amount of Chinese patent medicines, be used for the treatment of chronic hepatitis B, although pathological changes or drug resistance can not occur long-term taking, all there is specific aim difference, take effect slow shortcoming.

Summary of the invention

Technical problem to be solved by this invention is, provide a kind of Chinese medicine and preparation method for the treatment of caused by hepatic stagnation qi stagnation chronic hepatitis B, Chinese medicine of the present invention to caused by hepatic stagnation qi stagnation chronic hepatitis B have definite curative effect, with strong points, instant effect, toxic and side effects are little and relapse rate is low.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of caused by hepatic stagnation qi stagnation chronic hepatitis B, each raw medicinal material of described Chinese medicine comprises: Rhizoma Begoniae Fimbristipulatae, Rhizoma panacis majoris, Herba Catharanthi Rosei, Radix Fici comatae, Caulis aristolochiae moupinensis, Herba Bulbophylli Odoratissim, Flos Magnoliae Officinalis, Radix Eriobotryae, Fructus Akebiae, Fructus Hedychii Spicati, Herba Thymi, Radix Ervatamiae Hainanensis, Herba Linderniae Antipodae, Herba Homalocladii Platycladii, Herba Melastomatis dodecandri, Herba Maesae Prelarii, Radix Cissi Kerrii, Semen Impatientis, Caulis te Folium Callicarpae Longissimae and Radix eriosematis chinensis.

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Rhizoma Begoniae Fimbristipulatae 15 ~ 30 parts, Rhizoma panacis majoris 10 ~ 25 parts, Herba Catharanthi Rosei 15 ~ 35 parts, Radix Fici comatae 25 ~ 35 parts, Caulis aristolochiae moupinensis 20 ~ 45 parts, Herba Bulbophylli Odoratissim 15 ~ 38 parts, Flos Magnoliae Officinalis 10 ~ 25 parts, Radix Eriobotryae 5 ~ 25 parts, Fructus Akebiae 15 ~ 35 parts, Fructus Hedychii Spicati 5 ~ 15 parts, Herba Thymi 5 ~ 25 parts, Radix Ervatamiae Hainanensis 20 ~ 35 parts, Herba Linderniae Antipodae 15 ~ 40 parts, Herba Homalocladii Platycladii 15 ~ 35 parts, Herba Melastomatis dodecandri 10 ~ 30 parts, Herba Maesae Prelarii 15 ~ 35 parts, Radix Cissi Kerrii 20 ~ 35 parts, Semen Impatientis 25 ~ 45 parts, Caulis te Folium Callicarpae Longissimae 5 ~ 20 parts and Radix eriosematis chinensis 10 ~ 30 parts.

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Rhizoma Begoniae Fimbristipulatae 17 ~ 28 parts, Rhizoma panacis majoris 13 ~ 23 parts, Herba Catharanthi Rosei 20 ~ 30 parts, Radix Fici comatae 30 ~ 35 parts, Caulis aristolochiae moupinensis 25 ~ 35 parts, Herba Bulbophylli Odoratissim 25 ~ 35 parts, Flos Magnoliae Officinalis 12 ~ 22, Radix Eriobotryae 10 ~ 20 parts, Fructus Akebiae 20 ~ 30 parts, Fructus Hedychii Spicati 6 ~ 12 parts, Herba Thymi 8 ~ 23 parts, Radix Ervatamiae Hainanensis 22 ~ 30 parts, Herba Linderniae Antipodae 25 ~ 38 parts, Herba Homalocladii Platycladii 18 ~ 32 parts, Herba Melastomatis dodecandri 15 ~ 25 parts, Herba Maesae Prelarii 20 ~ 30 parts, Radix Cissi Kerrii 25 ~ 33 parts, Semen Impatientis 30 ~ 40 parts, Caulis te Folium Callicarpae Longissimae 6 ~ 15 parts and Radix eriosematis chinensis 15 ~ 25 parts.

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Rhizoma Begoniae Fimbristipulatae 25 parts, Rhizoma panacis majoris 15 parts, Herba Catharanthi Rosei 26 parts, Radix Fici comatae 33 parts, Caulis aristolochiae moupinensis 34 parts, Herba Bulbophylli Odoratissim 25 parts, Flos Magnoliae Officinalis 20 parts, Radix Eriobotryae 18 parts, Fructus Akebiae 22 parts, Fructus Hedychii Spicati 11 parts, Herba Thymi 10 parts, Radix Ervatamiae Hainanensis 28 parts, Herba Linderniae Antipodae 25 parts, Herba Homalocladii Platycladii 30 parts, Herba Melastomatis dodecandri 18 parts, Herba Maesae Prelarii 26 parts, Radix Cissi Kerrii 26 parts, Semen Impatientis 38 parts, Caulis te Folium Callicarpae Longissimae 8 parts and Radix eriosematis chinensis 23 parts.

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Rhizoma Begoniae Fimbristipulatae 20 parts, Rhizoma panacis majoris 20 parts, Herba Catharanthi Rosei 21 parts, Radix Fici comatae 30 parts, Caulis aristolochiae moupinensis 25 parts, Herba Bulbophylli Odoratissim 30 parts, Flos Magnoliae Officinalis 15 parts, Radix Eriobotryae 13 parts, Fructus Akebiae 27 parts, Fructus Hedychii Spicati 6 parts, Herba Thymi 20 parts, Radix Ervatamiae Hainanensis 23 parts, Herba Linderniae Antipodae 35 parts, Herba Homalocladii Platycladii 20 parts, Herba Melastomatis dodecandri 23 parts, Herba Maesae Prelarii 21 parts, Radix Cissi Kerrii 30 parts, Semen Impatientis 33 parts, Caulis te Folium Callicarpae Longissimae 13 parts and Radix eriosematis chinensis 17 parts.

When above-mentioned the dosage form of Chinese medicine is capsule described in any one time, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85% ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.

When above-mentioned the dosage form of Chinese medicine is tablet described in any one time, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85% ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.

Beneficial effect of the present invention: Chinese medicine of the present invention, according to tcm treatment according to syndrome differentiation principle, with strong points to caused by hepatic stagnation qi stagnation chronic hepatitis B, have definite curative effect, instant effect, toxic and side effects is little and relapse rate is low.

Detailed description of the invention

The invention provides a kind of Chinese medicine for the treatment of caused by hepatic stagnation qi stagnation chronic hepatitis B, its raw medicinal material comprises: Rhizoma Begoniae Fimbristipulatae, Rhizoma panacis majoris, Herba Catharanthi Rosei, Radix Fici comatae, Caulis aristolochiae moupinensis, Herba Bulbophylli Odoratissim, Flos Magnoliae Officinalis, Radix Eriobotryae, Fructus Akebiae, Fructus Hedychii Spicati, Herba Thymi, Radix Ervatamiae Hainanensis, Herba Linderniae Antipodae, Herba Homalocladii Platycladii, Herba Melastomatis dodecandri, Herba Maesae Prelarii, Radix Cissi Kerrii, Semen Impatientis, Caulis te Folium Callicarpae Longissimae and Radix eriosematis chinensis.

In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:

Rhizoma Begoniae Fimbristipulatae: cross that red, red water certain herbaceous plants with big flowers, loose blood, Rhizoma Begoniae Willsonii, Radix Ardisiae Punctatae, a leaf are red, blaubok at [another name] red autumnal leaves, dragon and tiger leaf, night.[source] medical material Ji Yuan: be bulb or the Herb of Begoniaceae plant Radix Semiaquilegiae.[nature and flavor] sweet in the mouth, cool in nature.[function cures mainly] clearing away heat and cooling blood; Relieving cough and resolving phlegm; Removing toxic substances and promoting subsidence of swelling.Main exogenous high fever; Heatstroke; Cough due to lung-heat; Laryngopharynx swelling and pain; Furuncle; Scrofula; Scabies; Burn and scald; Traumatic injury stasis of blood pain.[extracts] " China's book on Chinese herbal medicine "

Rhizoma panacis majoris: [another name] pearl ginseng, button seven, Pestalotia funera, Rhizoma Panacis Japonici, pimple seven, Rhizoma Panacis Majoris, Herba Senecionis Chrysanthemoidis, dish seven, wild Radix Notoginseng, band JIESHEN Radix Notoginseng.[source] medical material Ji Yuan: be the rhizome of Araliaceae Rhizoma panacis majoris.[nature and flavor] bitter in the mouth; Sweet; Cold in nature.[function cures mainly] clearing away heat and nourishing YIN; Dissipating blood stasis stops blooding; Reducing swelling and alleviating pain.Main calentura excessive thirst; Deficiency of YIN cough due to lung-heat; Hemoptysis; Spit blood; Epistaxis; Have blood in stool; Hematuria; Metrorrhagia; Traumatic hemorrhage; Traumatic injury wound is swollen; Rheumatic arthralgia; Stomachache; Menoxenia; Acute toothache; Laryngopharynx swelling and pain; Sore and toxic.[extracts] " China's book on Chinese herbal medicine "

Herba Catharanthi Rosei: [another name] Herba amaranthi tricoloris, everyday new, four time the spring, 30,000 flowers, Folium Lantanae Camarae, everyday spring, four time colored, red Herba Catharanthi Rosei.[source] medical material Ji Yuan: be the herb of apocynaceae plant Herba Catharanthi Rosei, yellow Herba Catharanthi Rosei.[nature and flavor] are bitter; Cold in nature.[return through] liver; Kidney channel.[function cures mainly] detoxicating and fighting cancer; Heat clearing away suppressing the hyperactive liver.Main multiple cancerous protuberance; Hypertension; Carbuncle sore tumefacting virus; Scald.[extracts] " China's book on Chinese herbal medicine "

Radix Fici comatae: [another name] sow essence, car pusher enter stone, lobule Sabia schumanniana Diels.[source] medical material Ji Yuan: be moraceae plants fruitlet banyan root.[nature and flavor] are sweet; Micro-pungent; Warm in nature.[function cures mainly] dispels the wind; Spleen invigorating; Dampness removing; Main air pain of dampness syndrome; Acute infantile convulsion; Overstrain is weak; Dyspepsia; Lukorrhagia due to hypofunction of the spleen .[takes passages] " China's book on Chinese herbal medicine "

Radix Fici comatae: [another name] sow essence, car pusher enter stone, lobule Sabia schumanniana Diels.[source] medical material Ji Yuan: be moraceae plants fruitlet banyan root.[nature and flavor] are sweet; Micro-pungent; Warm in nature.[function cures mainly] dispels the wind; Spleen invigorating; Dampness removing; Main air pain of dampness syndrome; Acute infantile convulsion; Overstrain is weak; Dyspepsia; Lukorrhagia due to hypofunction of the spleen .[takes passages] " China's book on Chinese herbal medicine "

Caulis aristolochiae moupinensis: [another name] Huaihe River Caulis Akebiae, Caulis aristolochiae moupinensis Fructus Aristolochiae, reason Radix Stephaniae Tetrandrae, Radix Cocculi Orbiculati, rock see to be known.[source] medical material Ji Yuan: be ratan or the root of the stem of aristolochiaceae plant Baoxing Fructus Aristolochiae.Latin plant animal mineral name: Aristolochia moupinensis Franch.[nature and flavor] are bitter; Pungent; Cold.[return through] heart; Kidney; Bladder; Small intestine meridian.[function cures mainly] clearing away heat-damp and promoting diuresis; Wind-expelling pain-stopping.Main dysentery stomachache; Hygropyretic edema; Hot urination; Hematuria; Beriberoid pyretic arthralgia; Carbuncle malignant boil; Eczema; Venom.[extracts] " China's book on Chinese herbal medicine "

Herba Bulbophylli Odoratissim: [another name] little Herba Bulbophylli Odoratissim, Bulbophyllum calodictyon schlecht., extremely fragrant Bulbophyllum, elaeagnus conferta fruits.[source] medical material Ji Yuan: be the herb of orchid Bulbophyllum odoratissimum Lindl..[nature and flavor] are sweet; Light; Cool.[return through] lung; Liver; Kidney channel.[function cures mainly] moistening the lung and resolving phlegm; Removing obstruction in the collateral to relieve pain.Main hemoptysis of pulmonary tuberculosis; Chronic tracheitis; Chronic pharyngitis; Hernia pain; Menoxenia; Rheumatic arthralgia; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Flos Magnoliae Officinalis: [another name] spoon flower.[source] medical material Ji Yuan: be the alabastrum of Magnoliacea plant Cortex Magnoliae Officinalis or Mount Lushan Cortex Magnoliae Officinalis.[nature and flavor] are pungent; Micro-hardship; Warm in nature.[return through] spleen; Stomach; Lung meridian.[function cures mainly] promoting the circulation of QI to alleviate the stagnation in middle-JIAO; Dissipating depression of QI removing dampness.Main stagnation of liver-QI and stomach-QI; Breast gastral cavity feeling of distension and oppression; Inappetence; Poor appetite; The cards such as cold cough.[extracts] " China's book on Chinese herbal medicine "

Radix Eriobotryae: [source] medical material Ji Yuan: be the seed of rosaceous plant Folium Eriobotryae.[nature and flavor] are bitter; Flat; Nontoxic.[return through] kidney channel.[function cures mainly] preventing phlegm from forming and stopping coughing; Soothing the liver circulation of qi promoting; Inducing diuresis to remove edema.Main cough with copious phlegm; Hernia; Edema; Scrofula.[extracts] " China's book on Chinese herbal medicine "

Fructus Akebiae: [another name] poultry Weed, take son, small wooden raft Im, cover son, August short, bristly hair or beard, Caulis Akebiae son, son of helping get over a shock, Fructus Akebiae, Fructus Akebiae, August explode, August fruit, one hundred days melon, lead rattan melon, cold meal bag, draw really, open country perfume friendship, YANGKAIKOU, cured melon.[source] medical material Ji Yuan: be the mature fruit of plants of Lardizabalaceae Caulis Akebiae, threeleaf akebia.[nature and flavor] hide micro-hardship, and property is put down.Return liver, stomach, urinary bladder channel.[return through] liver; Stomach warp.[function cures mainly] dispersing the stagnated liver-QI for regulating the stomach, promoting blood circulation and stopping pain, hard masses softening and resolving, diuresis.Main stagnation of liver-QI and stomach-QI, gastral cavity abdomen, the side of body help distending pain, and diet does not disappear, and dysentery is just let out, hernia pain, lumbago, amenorrhea dysmenorrhea, goiter scrofula, malignant tumor.[extracts] " China's book on Chinese herbal medicine "

Fructus Hedychii Spicati: [another name] Fructus Amomi Rotundus, little Fructus Tsaoko, SEMEN TSAOKO.[source] medical material Ji Yuan: be the fruit of zingiberaceous plant Fructus Hedychii Spicati.Latin plant animal mineral name: Hedychium spicatum Ham.Ex Smith[nature and flavor] acrid in the mouth; Micro-hardship; Warm in nature.[return through] liver; Stomach warp.[function cures mainly] warming spleen and stomach for dispelling cold; Regulate the flow of vital energy and help digestion.Main cold syndrome of the stomach epigastric pain; Dyspeptic abdominal distention; Colic of cold type is suffered from abdominal pain.[extracts] " China's book on Chinese herbal medicine "

Herba Thymi: [another name] ground Pericarpium Zanthoxyli, Herba thymi vulgaris, Pericarpium Zanthoxyli, Fructus Linderae Glaucae.[source] medical material Ji Yuan: be hundred li of noons of labiate or the herb opening up hair Herba Thymi.[nature and flavor] acrid in the mouth; Property is put down; Mild toxicity.[function cures mainly] dispelling wind stopping cough; Spleen invigorating circulation of qi promoting; Dampness removing is treating stranguria.Main headache due to common cold; Cough; Pertussis; Epigastric pain; Dyspepsia; Vomiting and diarrhoea; Toothache; Difficulty and pain in micturition; Eczema pruritus; Sore, carbuncle and painful swelling.[extracts] " China's book on Chinese herbal medicine "

Radix Ervatamiae Hainanensis: [another name] only son and heir wood, taberpsychine tree, Ai Jiaoqing, thunder-crash bomb, chicken feet flower.[source] medical material Ji Yuan: be root or the leaf of apocynaceae plant Ervatamia hainanensis.Latin plant animal mineral name: Ervatamia hainanensis Tsiang.[nature and flavor] are bitter; Pungent; Cool in nature.[return through] liver; Stomach; Large intestine channel.[function cures mainly] heat-clearing and toxic substances removing; Blood pressure lowering; Reducing swelling and alleviating pain.Main hypertension; Laryngopharynx swelling and pain; Rheumatic arthralgia; Traumatic injury; Carbuncle furuncle; Venom.[extracts] " China's book on Chinese herbal medicine "

Herba Linderniae Antipodae: [another name] field jasmine, purple Fel Ursi, water Fructus Capsici, Herba Linderniae anagallis, Lindernia angustifolia (Benth.) Wettst., field Fructus Musae, Fei Huangcao, the broken grass of rice, white bud river, Eriocheir sinensis fork grass.[source] medical material Ji Yuan: the herb of ginseng section plant puree flowers and plants.[nature and flavor] sweet in the mouth; Micro-hardship; Cold in nature.[function cures mainly] heat-clearing and toxic substances removing; Inducing diuresis for treating stranguria syndrome; Promoting blood circulation and detumescence.Main cough due to lung-heat; Laryngopharynx swelling and pain; Have loose bowels; Pyretic stranguria; Conjunctival congestion and swelling pain; Carbuncle furunculosis; Traumatic injury; Venom.[extracts] " China's book on Chinese herbal medicine "

Herba Homalocladii Platycladii: [another name] fernleaf hedge bamboo, ferrum turn round limit, upper Shi Baizhu, Caulis et Folium Pothi Repentis, Scolopendra bamboo, flat bamboo, Andrographis paniculata(Burm.f.）Nees, chicken feet Scolopendra, Herba pteridis vittatae, flat bamboo, Twotooth Achyranthes Root, ring mountain grass, centipede mountain grass, university degree Caulis et Folium Pothi Repentis, mottled bamboo is similar, cold avoids bamboo, goose river grass.[source] medical material Ji Yuan: be the herb of polygonaceae plant Herba Homalocladii Platycladii.[nature and flavor] are sweet; Light; Property is put down.[return through] liver; Lung meridian.[function cures mainly] heat-clearing and toxic substances removing; Blood stasis removing is subsided a swelling.Main swollen ulcer drug; Traumatic injury; Serpentis; Insect bite wound [extracts] " China's book on Chinese herbal medicine "

Herba Melastomatis dodecandri: [another name] Radix Solani Melongenae, Herba Melastomatis dodecandri root, Linesless charcoal bubble.[source] medical material Ji Yuan: the root of Melastomateae plants Herba Melastomatis Dodecandri.Latin plant animal mineral name: Melastoma dodecandrum Lour.[nature and flavor] bitter in the mouth; Micro-sweet; Property is put down.[return through] returns liver; Spleen; Lung meridian.[function cures mainly] invigorates blood circulation; Hemostasis; Dampness removing; Removing toxic substances.Main dysmenorrhea; Difficult labour; Puerperal abdonimal pain; Retention of placenta; Metrorrhagia; Leucorrhea; Cough; Spit blood; Dysentery; Jaundice; Drench pain; Chronic malaria; Rheumatalgia; Toothache; Scrofula; Hernia; Traumatic injury impairment caused by overstrain; Venom.[extracts] " China's book on Chinese herbal medicine "

Herba Maesae Prelarii: [another name] Canis familiaris L. belly, cow dung wood, yellow tea, kwan-yin tea, soft textive wood, fourth medicine, Fructus Viburni Foetidi.[source] medical material Ji Yuan: be the Herb of Myrsinacea plant Carassius auratus fertilizer.[nature and flavor] are bitter; Property is put down.[return through] heart; Liver Channel.[function cures mainly] synthetism is subsided a swelling; Removing the necrotic tissue and promoting granulation.Main injury and bone fracture; Knife injury; Furuncle abscess.[extracts] " China's book on Chinese herbal medicine "

Radix Cissi Kerrii: [another name] mountain Ipomoea batatas Lam., Radix Rumicis, unipods crow button, mountain calabash, powder rattan head, powder rattan potato, tuber Radix Codonopsis convolvulaceae, powder rattan egg.[source] medical material Ji Yuan: be the tuber of vitaceae Cissus repens.[nature and flavor] are bitter; Micro-pungent; Cool in nature.[return through] heart; Kidney channel.[function cures mainly] promoting blood circulation to remove obstruction in the collateral; Dissipating phlegm and resolving masses; Removing toxicity for eliminating carbuncles.Main traumatic injury; Rheumatic arthralgia; Scrofula sucutaneous nodule; Carbuncle sore tumefacting virus; Venom.[extracts] " China's book on Chinese herbal medicine "

Semen Impatientis: [another name] buttercup, SEMEN IMPATIENTIS.[source] medical material Ji Yuan: be the seed of Balsaminaceae plant Impatientis.Latin plant animal mineral name: Impatiens balsamina L.[nature and flavor] are pungent; Bitter; Temperature; Mild toxicity.[return through] kidney; Liver; Lung meridian.[function cures mainly] clots absorbing sending down the abnormal ascending QI; Hard masses softening and resolving.Main warp closes; Dysmenorrhea; Dystocia; Retention of placenta in puerperal, dysphagic; Mass in the abdomen; Bone is choked; Dirty tooth; Sore swollen toxin.[extracts] " China's book on Chinese herbal medicine "

Caulis te Folium Callicarpae Longissimae: [another name] fine stern peak, play crazy solarization, catch up with wind to shine, catch up with that wind is handsome, Radix Polygoni Ciliinerve is sub, Folium et Ramulus Callicarpae nudiflorae, black joint wind, wind of shaking hands, stickyly hold in the hand wind, wear GUFENG, big blade, Lian Yufeng, snow are prominent, cow tongue Huang.[source] medical material Ji Yuan: be stem, the leaf of Verbenaceae Folium Callicarpae Longissimae.[nature and flavor] acrid in the mouth; Micro-hardship; Warm in nature.[function cures mainly] expelling wind and cold; Dissipating blood stasis stops blooding; Removing toxic substances and promoting subsidence of swelling.Main cough due to wind and cold; Abdominal pain due to accumulation of cold; Rheumatic arthralgia; Traumatic injury; Interior traumatic hemorrhage; Innominate toxic swelling.[extracts] " China's book on Chinese herbal medicine "

Radix eriosematis chinensis: [another name] mountain Pueraria lobota, energetically cattle, Caput Gallus domesticus potato, Cor Gigeriae Galli potato, Caput Gallus domesticus, yam bean, mountain stilbene potato, Herba Violae mundae.[source] medical material Ji Yuan: be the tuber of leguminous plant Radix eriosematis chinensis.Latin plant animal mineral name: Eriosema chinense Vog.[nature and flavor] sweet; Flat.[return through] lung; Large intestine; Liver Channel.[function cures mainly] removing heat from the lung and dissipating phlegm; Promoting the production of body fluid to quench thirst; Detumescence.Main cough due to lung-heat; Lung abscess; Heating excessive thirst; Dysentery; Hydrocele of testis, food stagnation does not disappear; Treating swelling and pain by traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Rhizoma Begoniae Fimbristipulatae 15 ~ 30 parts, Rhizoma panacis majoris 10 ~ 25 parts, Herba Catharanthi Rosei 15 ~ 35 parts, Radix Fici comatae 25 ~ 35 parts, Caulis aristolochiae moupinensis 20 ~ 45 parts, Herba Bulbophylli Odoratissim 15 ~ 38 parts, Flos Magnoliae Officinalis 10 ~ 25 parts, Radix Eriobotryae 5 ~ 25 parts, Fructus Akebiae 15 ~ 35 parts, Fructus Hedychii Spicati 5 ~ 15 parts, Herba Thymi 5 ~ 25 parts, Radix Ervatamiae Hainanensis 20 ~ 35 parts, Herba Linderniae Antipodae 15 ~ 40 parts, Herba Homalocladii Platycladii 15 ~ 35 parts, Herba Melastomatis dodecandri 10 ~ 30 parts, Herba Maesae Prelarii 15 ~ 35 parts, Radix Cissi Kerrii 20 ~ 35 parts, Semen Impatientis 25 ~ 45 parts, Caulis te Folium Callicarpae Longissimae 5 ~ 20 parts and Radix eriosematis chinensis 10 ~ 30 parts.

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Rhizoma Begoniae Fimbristipulatae 17 ~ 28 parts, Rhizoma panacis majoris 13 ~ 23 parts, Herba Catharanthi Rosei 20 ~ 30 parts, Radix Fici comatae 30 ~ 35 parts, Caulis aristolochiae moupinensis 25 ~ 35 parts, Herba Bulbophylli Odoratissim 25 ~ 35 parts, Flos Magnoliae Officinalis 12 ~ 22, Radix Eriobotryae 10 ~ 20 parts, Fructus Akebiae 20 ~ 30 parts, Fructus Hedychii Spicati 6 ~ 12 parts, Herba Thymi 8 ~ 23 parts, Radix Ervatamiae Hainanensis 22 ~ 30 parts, Herba Linderniae Antipodae 25 ~ 38 parts, Herba Homalocladii Platycladii 18 ~ 32 parts, Herba Melastomatis dodecandri 15 ~ 25 parts, Herba Maesae Prelarii 20 ~ 30 parts, Radix Cissi Kerrii 25 ~ 33 parts, Semen Impatientis 30 ~ 40 parts, Caulis te Folium Callicarpae Longissimae 6 ~ 15 parts and Radix eriosematis chinensis 15 ~ 25 parts.

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Rhizoma Begoniae Fimbristipulatae 25 parts, Rhizoma panacis majoris 15 parts, Herba Catharanthi Rosei 26 parts, Radix Fici comatae 33 parts, Caulis aristolochiae moupinensis 34 parts, Herba Bulbophylli Odoratissim 25 parts, Flos Magnoliae Officinalis 20 parts, Radix Eriobotryae 18 parts, Fructus Akebiae 22 parts, Fructus Hedychii Spicati 11 parts, Herba Thymi 10 parts, Radix Ervatamiae Hainanensis 28 parts, Herba Linderniae Antipodae 25 parts, Herba Homalocladii Platycladii 30 parts, Herba Melastomatis dodecandri 18 parts, Herba Maesae Prelarii 26 parts, Radix Cissi Kerrii 26 parts, Semen Impatientis 38 parts, Caulis te Folium Callicarpae Longissimae 8 parts and Radix eriosematis chinensis 23 parts.

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine can be preferably as follows: Rhizoma Begoniae Fimbristipulatae 20 parts, Rhizoma panacis majoris 20 parts, Herba Catharanthi Rosei 21 parts, Radix Fici comatae 30 parts, Caulis aristolochiae moupinensis 25 parts, Herba Bulbophylli Odoratissim 30 parts, Flos Magnoliae Officinalis 15 parts, Radix Eriobotryae 13 parts, Fructus Akebiae 27 parts, Fructus Hedychii Spicati 6 parts, Herba Thymi 20 parts, Radix Ervatamiae Hainanensis 23 parts, Herba Linderniae Antipodae 35 parts, Herba Homalocladii Platycladii 20 parts, Herba Melastomatis dodecandri 23 parts, Herba Maesae Prelarii 21 parts, Radix Cissi Kerrii 30 parts, Semen Impatientis 33 parts, Caulis te Folium Callicarpae Longissimae 13 parts and Radix eriosematis chinensis 17 parts.

When above-mentioned the dosage form of Chinese medicine is capsule described in any one time, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85% ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.

When above-mentioned the dosage form of Chinese medicine is tablet described in any one time, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85% ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.

Embodiment 1: capsule

Get Rhizoma Begoniae Fimbristipulatae 200g, Rhizoma panacis majoris 200g, Herba Catharanthi Rosei 210g, Radix Fici comatae 300g, Caulis aristolochiae moupinensis 250g, Herba Bulbophylli Odoratissim 300g, Flos Magnoliae Officinalis 150g, Radix Eriobotryae 130g, Fructus Akebiae 270g, Fructus Hedychii Spicati 60g, Herba Thymi 200g, Radix Ervatamiae Hainanensis 230g, Herba Linderniae Antipodae 350g, Herba Homalocladii Platycladii 200g, Herba Melastomatis dodecandri 230g, Herba Maesae Prelarii 210g, Radix Cissi Kerrii 300g, Semen Impatientis 330g, Caulis te Folium Callicarpae Longissimae 130g and Radix eriosematis chinensis 170g.

Its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 95%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1.5 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.4:0.37, incapsulate in housing by described capsule 's content, obtain capsule finished product.

Embodiment 2: tablet

Get Rhizoma Begoniae Fimbristipulatae 250g, Rhizoma panacis majoris 150g, Herba Catharanthi Rosei 260g, Radix Fici comatae 330g, Caulis aristolochiae moupinensis 340g, Herba Bulbophylli Odoratissim 250g, Flos Magnoliae Officinalis 200g, Radix Eriobotryae 180g, Fructus Akebiae 220g, Fructus Hedychii Spicati 110g, Herba Thymi 100g, Radix Ervatamiae Hainanensis 280g, Herba Linderniae Antipodae 250g, Herba Homalocladii Platycladii 300g, Herba Melastomatis dodecandri 180g, Herba Maesae Prelarii 260g, Radix Cissi Kerrii 260g, Semen Impatientis 380g, Caulis te Folium Callicarpae Longissimae 80g and Radix eriosematis chinensis 230g.

Its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 80%, reflux 1 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1.5 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 300 object micropowders;

3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.2 times, 0.1 times of lactose, the starch of 0.2 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.04 times of magnesium stearate, granulate, tabletting, makes.

Toxicity test:

Acute toxicity testing: application mice 60, male and female half and half, body weight 20 ~ 29g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicine capsules prepared by embodiments of the invention 1, (concentration is 8.46g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 42.3 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record toxic reaction and the death toll of mice.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage capsule LD50>42.3 crude drug/kg of the present invention, every day, maximum dosage-feeding was 84.6 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 7.8g crude drug/day/people, adult body weight in 60KG, average dosage is 0.13g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 24g) oral administration gavage Chinese medicine of the present invention is 651 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: Chinese medicine embodiment 1 capsule of the present invention presses 12.32,20.68 and 35.42g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: whole 100 routine cases are my Out-patient Department or inpatient, wherein, male 44 example, women 56 example, 16 ~ 56 years old age, the course of disease 6 months ~ 13 years 2 months.Be divided into treatment group and matched group at random, wherein treatment group 50 people, wherein, male 22 example, women 28 example, 16 ~ 54 years old age, the course of disease 6 months ~ 12 years 9 months.Matched group 50 people, wherein, male 22 example, women 28 example, 17 ~ 56 years old age, the course of disease 7 months ~ 13 years 2 months.Two groups of ages, diseased region, clinical manifestation and equal not statistically significants of coincident with severity degree of condition comparing difference (p>0.05).

Diagnostic criteria: meet following Western medicine diagnose standard and Standards of Chinese Medical Syndrome Differentiation

Western medicine diagnose standard: infect credit can combine formulation " the guideline " with reference to Chinese Medical Association's hepatopathy credit meeting, Chinese Medical Association.

Standards of Chinese Medical Syndrome Differentiation: caused by hepatic stagnation qi stagnation: under right flank, dull pain or distending pain connect and stomach, uncomfortable in chest, belch, indigestion and loss of appetite lack of appetite, spiritlessness and weakness, exacerbation of symptoms after anxious state of mind or overstrain, sighing frequently or see low grade fever bitter taste, vexed insomnia, thin white fur of tongue or BOHUANG, stringy pulse.

Therapeutic Method:

Treatment group: give the embodiment of the present invention 1 capsule every day 3 times, each 3, to be used in conjunction 12 months;

Matched group: give lamivudine, each 100mg, every day 1 time, is used in conjunction 12 months.

Observational technique: two groups of cases are except pressing the conventional diagnosis and treatment record of outpatient service, all Detailed Inspections before and after medication: as symptom, picture of the tongue, pulse condition, sign and physical and chemical index ALT, albumin, globulin, A/G, HBV blood serum designated object, B ultrasonic look into liver and gall spleen, monthly check once, carry out comprehensive record, as the foundation terminating rear evaluation curative effect the course for the treatment of.

Curative effect judging standard: effective: clinical symptom disappearance, hepatosplenomegaly retraction or disappearance (B ultrasonic), without tenderness and percussion pain, liver function recovery is normal, and HBV-DNA turns out cloudy, e antigen serological conversion; Effective: clinical symptoms is obviously improved or disappeared, hepatosplenomegaly retraction (B ultrasonic), hepatic region is without obvious tenderness and percussion pain, and liver function is normal, and HBV-DNA is qualitative not to be become, and five indexes of hepatitis b is unchanged; Invalid: clinical symptoms, sign, liver function, hepatitis B virus Virus monitory all do not change or increase the weight of.

Therapeutic outcome: two groups treat 1 year respectively after, total effects statistical result is see table 1.

A table 1 liang group treats two groups of comparitive study (example) after 6 months respectively:

Group	n	Effective	Effectively	Invalid	Effectively total
						Treatment group	50	37	11	2	48(96％)
Matched group	50	18	24	8	42(84％)

As can be seen from Table 1, adopt treatment by Chinese herbs caused by hepatic stagnation qi stagnation chronic hepatitis B of the present invention, relative to matched group, on therapeutic effect, there is significant improvement.

Two groups treat 1 year respectively after, two groups of effective numbers and effective time situation statistics in table 2.

A table 2 liang group treats effective number and time comparative example (%) after 6 months respectively

Group	n	Medication 3 months	Medication 6 months	Medication 9 months	Medication 12 months
						Treatment group	37	6(12％)	19(38％)	29(58％)	37(74％)
Matched group	18	2(4％)	8(16％)	14(28％)	18(36％)

As can be seen from Table 2, adopt treatment by Chinese herbs caused by hepatic stagnation qi stagnation chronic hepatitis B of the present invention, relative to matched group, not only better efficacy, and also it is faster to take effect.

According to the clinical statistics in above table, Chinese medicine provided by the invention have rapid-action, effective percentage is high, safety is high, the advantage that has no side effect; Follow up a case by regular visits to 1 year respectively to the effective 37 routine patients for the treatment of group and the effective 18 routine patients of matched group, result is added up, and treatment group is without recurrence, and relapse rate is 0% simultaneously; The routine patient of matched group 18, recurs 2 people, relapse rate 11.1%.

Concrete case: Lee, male, 42 years old, there is family's hepatitis B history, suffer from chronic viral hepatitis B 6 years half, TCM syndrome: right distending pain in the hypochondrium connects and stomach, uncomfortable in chest, belch, indigestion and loss of appetite lack of appetite, spiritlessness and weakness, exacerbation of symptoms after anxious state of mind or overstrain, low grade fever bitter taste, vexed insomnia, tongue fur BOHUANG, stringy pulse, is diagnosed as caused by hepatic stagnation qi stagnation chronic hepatitis B.Give Chinese medicine embodiment 1 capsule of the present invention every day 3 times, each 3, treat after 6 months, clinical symptoms all disappears, and liver function recovery is normal, and HBV-DNA turns out cloudy, e antigen serological conversion, continues to take drug withdrawal in 1 month, follows up a case by regular visits to and does not recur for 1 year.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (9)

1. treat the Chinese medicine of caused by hepatic stagnation qi stagnation chronic hepatitis B for one kind, it is characterized in that, each raw medicinal material of described Chinese medicine comprises: Rhizoma Begoniae Fimbristipulatae, Rhizoma panacis majoris, Herba Catharanthi Rosei, Radix Fici comatae, Caulis aristolochiae moupinensis, Herba Bulbophylli Odoratissim, Flos Magnoliae Officinalis, Radix Eriobotryae, Fructus Akebiae, Fructus Hedychii Spicati, Herba Thymi, Radix Ervatamiae Hainanensis, Herba Linderniae Antipodae, Herba Homalocladii Platycladii, Herba Melastomatis dodecandri, Herba Maesae Prelarii, Radix Cissi Kerrii, Semen Impatientis, Caulis te Folium Callicarpae Longissimae and Radix eriosematis chinensis.

2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Rhizoma Begoniae Fimbristipulatae 15 ~ 30 parts, Rhizoma panacis majoris 10 ~ 25 parts, Herba Catharanthi Rosei 15 ~ 35 parts, Radix Fici comatae 25 ~ 35 parts, Caulis aristolochiae moupinensis 20 ~ 45 parts, Herba Bulbophylli Odoratissim 15 ~ 38 parts, Flos Magnoliae Officinalis 10 ~ 25 parts, Radix Eriobotryae 5 ~ 25 parts, Fructus Akebiae 15 ~ 35 parts, Fructus Hedychii Spicati 5 ~ 15 parts, Herba Thymi 5 ~ 25 parts, Radix Ervatamiae Hainanensis 20 ~ 35 parts, Herba Linderniae Antipodae 15 ~ 40 parts, Herba Homalocladii Platycladii 15 ~ 35 parts, Herba Melastomatis dodecandri 10 ~ 30 parts, Herba Maesae Prelarii 15 ~ 35 parts, Radix Cissi Kerrii 20 ~ 35 parts, Semen Impatientis 25 ~ 45 parts, Caulis te Folium Callicarpae Longissimae 5 ~ 20 parts and Radix eriosematis chinensis 10 ~ 30 parts.

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Rhizoma Begoniae Fimbristipulatae 17 ~ 28 parts, Rhizoma panacis majoris 13 ~ 23 parts, Herba Catharanthi Rosei 20 ~ 30 parts, Radix Fici comatae 30 ~ 35 parts, Caulis aristolochiae moupinensis 25 ~ 35 parts, Herba Bulbophylli Odoratissim 25 ~ 35 parts, Flos Magnoliae Officinalis 12 ~ 22, Radix Eriobotryae 10 ~ 20 parts, Fructus Akebiae 20 ~ 30 parts, Fructus Hedychii Spicati 6 ~ 12 parts, Herba Thymi 8 ~ 23 parts, Radix Ervatamiae Hainanensis 22 ~ 30 parts, Herba Linderniae Antipodae 25 ~ 38 parts, Herba Homalocladii Platycladii 18 ~ 32 parts, Herba Melastomatis dodecandri 15 ~ 25 parts, Herba Maesae Prelarii 20 ~ 30 parts, Radix Cissi Kerrii 25 ~ 33 parts, Semen Impatientis 30 ~ 40 parts, Caulis te Folium Callicarpae Longissimae 6 ~ 15 parts and Radix eriosematis chinensis 15 ~ 25 parts.

4. the Chinese medicine as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Rhizoma Begoniae Fimbristipulatae 25 parts, Rhizoma panacis majoris 15 parts, Herba Catharanthi Rosei 26 parts, Radix Fici comatae 33 parts, Caulis aristolochiae moupinensis 34 parts, Herba Bulbophylli Odoratissim 25 parts, Flos Magnoliae Officinalis 20 parts, Radix Eriobotryae 18 parts, Fructus Akebiae 22 parts, Fructus Hedychii Spicati 11 parts, Herba Thymi 10 parts, Radix Ervatamiae Hainanensis 28 parts, Herba Linderniae Antipodae 25 parts, Herba Homalocladii Platycladii 30 parts, Herba Melastomatis dodecandri 18 parts, Herba Maesae Prelarii 26 parts, Radix Cissi Kerrii 26 parts, Semen Impatientis 38 parts, Caulis te Folium Callicarpae Longissimae 8 parts and Radix eriosematis chinensis 23 parts.

5. the Chinese medicine as described in claims 1 to 3, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Rhizoma Begoniae Fimbristipulatae 20 parts, Rhizoma panacis majoris 20 parts, Herba Catharanthi Rosei 21 parts, Radix Fici comatae 30 parts, Caulis aristolochiae moupinensis 25 parts, Herba Bulbophylli Odoratissim 30 parts, Flos Magnoliae Officinalis 15 parts, Radix Eriobotryae 13 parts, Fructus Akebiae 27 parts, Fructus Hedychii Spicati 6 parts, Herba Thymi 20 parts, Radix Ervatamiae Hainanensis 23 parts, Herba Linderniae Antipodae 35 parts, Herba Homalocladii Platycladii 20 parts, Herba Melastomatis dodecandri 23 parts, Herba Maesae Prelarii 21 parts, Radix Cissi Kerrii 30 parts, Semen Impatientis 33 parts, Caulis te Folium Callicarpae Longissimae 13 parts and Radix eriosematis chinensis 17 parts.

6. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85% ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.

7. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85% ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.

8. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85% ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.

9. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85% ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.