CN101983716B - Medicine for treating gastric ulcer and duodenal ulcer and preparation method thereof - Google Patents

Medicine for treating gastric ulcer and duodenal ulcer and preparation method thereof Download PDF

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CN101983716B
CN101983716B CN2010105449574A CN201010544957A CN101983716B CN 101983716 B CN101983716 B CN 101983716B CN 2010105449574 A CN2010105449574 A CN 2010105449574A CN 201010544957 A CN201010544957 A CN 201010544957A CN 101983716 B CN101983716 B CN 101983716B
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radix
gram
herba
fructus
rhizoma
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CN101983716A (en
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许文成
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许文成
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Abstract

The invention discloses a medicine for treating gastric ulcer and duodenal ulcer. The medicine is mainly prepared by amomum fruit, angelica root, dried orange peel, gallnut, Chinese magnoliavine fruit, desmodium, Chinese wax, pseudo-ginseng and grains in certain weight proportion. The invention has the functions of tonifying spleen and stomach, regulating qi and eliminating dampness, clearing heat and excreting dampness as well as promoting tissue regeneration, curative effect on gastric ulcer and duodenal ulcer is quick, and curative ratio is high.

Description

A kind of medicine for the treatment of gastric and duodenal ulcers and preparation method thereof
Technical field
The present invention relates to a kind of medicine for the treatment of gastric and duodenal ulcers and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Gastric and duodenal ulcers is a kind of common frdquently encountered diseases of person in middle and old age, causes great harm and misery to patient health, gastral cavilty or abdominal pain during morbidity, limbs fatigue, inappetence, or bitter taste, halitosis, the tending to vomit of feeling sick, or retch, acid regurgitation water or clear water, hungry or on a full stomach pain increase the weight of anxious state of mind, pain such as overwork all can increase the weight of, western medicine, and side effect is big, the relapse rate height is difficult for radical cure.
Summary of the invention
Therefore people to curative effect preferably Chinese medicine have great demand, up to now, also do not find relevant report about medicine of the present invention.
The inventor has found the medicine that the radical cure of better curative effect gastric and duodenal ulcers is arranged finally, thereby has finished the present invention through research and clinical verification repeatedly.
Purpose of the present invention just provides a kind of composition of medicine with radically treating gastric and duodenal ulcers.
Another object of the present invention has just provided the preparation method of this composition of medicine.
Medicament selection Fructus Amomi of the present invention, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Fructus Foeniculi, Pseudobulbus Bletillae (Rhizoma Bletillae), Galla Chinensis, Fructus Schisandrae Chinensis, Pericarpium Citri Reticulatae Viride, Radix Curcumae, Rhizoma Corydalis, the Radix Paeoniae Alba, Herba Lysimachiae, Cera Chinensis, Radix Notoginseng, Rhizoma Alismatis, Poria, Poria cum Radix Pini, Chrysomyiame gacephala (Fab.), Radix Ampelopsis, Herba Agrimoniae, Radix Sanguisorbae, Rhizoma Polygoni Cuspidati, Fructus Anisi Stellati, Semen Alpiniae Katsumadai, Semen Myristicae, Fructus Amomi Rotundus, Endoconcha Sepiae, Herba Pogostemonis, Herba Eupatorii 29 flavor Chinese medicines make up, make each efficacy of drugs produce synergism these drug regimens, thus the recurrence that can effectively effect a radical cure gastric and duodenal ulcers.Wherein selecting Fructus Amomi for use is that temperature is gone into spleen, stomach warp because of its nature and flavor suffering, have in the circulation of qi promoting accent, and stomach function regulating, the function of being amusing is controlled the stomachache painful abdominal mass and is expanded anorexia dyspepsia, dysphagic vomiting, diarrhea due to cold pathogen cold-dysentery, pregnant fetal movement.Selecting the Radix Angelicae Dahuricae for use is that temperature is gone into lung, spleen, stomach warp because of its nature and flavor suffering, dispel the wind, and dampness, detumescence, the analgesic function is controlled headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp stomachache, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.Selecting Pericarpium Citri Reticulatae for use is that temperature is returned lung, spleen channel, and regulating qi-flowing for strengthening spleen is arranged because of its nature and flavor hardship, suffering, and drying dampness to eliminate phlegm is controlled fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.Selecting Fructus Foeniculi for use is that temperature is returned liver,kidney,spleen, stomach warp, and dispersing cold for relieving pain is arranged because of its nature and flavor suffering, and the function of regulating qi-flowing for harmonizing stomach is controlled colic of cold type stomachache, the testis swelling and hanging down of either of the testes, dysmenorrhea, few abdomen cold type of pain, distension and fullness in the abdomen, lack of appetite and vomiting, hydrocele of testis.Selecting Pseudobulbus Bletillae (Rhizoma Bletillae) for use is because its property bitter but sweet flavor, and lung meridian is gone in cold, and tonifying the lung is arranged, hemostasis, and detumescence, granulation promoting is held back the function of skin ulcer, and control lung and hinder hemoptysis, epistaxis, incised wound is hemorrhage, swollen ulcer drug, ulcer pain, the soup fire is burnt, rhagadia manus et pedis.Select for use Galla Chinensis to be because its nature and flavor acid is flat, go into lung, stomach, large intestine channel, astringe the lung, astringing intestine to stop diarrhea, hemostasis, the antidotal function is controlled chronic cough of deficiency lung, chronic dysentery, chronic diarrhea, proctoptosis, spontaneous perspiration, night sweat, epistaxis, metrorrhagia, traumatic hemorrhage, toxic swelling, furuncle, trichiasis are had blood in stool in seminal emission.Selecting Fructus Schisandrae Chinensis for use is that temperature is gone into lung, kidney channel, astringes the lung because of its nature and flavor acid, and nourishing kidney is promoted the production of body fluid, and receives antiperspirant, and the function of arresting seminal emission is controlled the deficiency of the lung and breathed with cough, and xerostomia is done thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery.Selecting Pericarpium Citri Reticulatae Viride for use is that tepor is gone into liver, gallbladder meridian, and soothing the liver dispelling the stagnated QI is arranged because of its nature and flavor toil, and the function of eliminating stagnation clearing away phlegm is controlled breast side of body gastralgia, hernia, food stagnation, swelling of the breast, nodule in the breast, chronic malaria addiction piece.Select for use Radix Curcumae to be because its nature and flavor are arduous, the heart, lung, Liver Channel are gone in cold, and the sector-style resolving depression is arranged, and the function of removing heat from blood removing blood stasis with potent drugs is controlled all pains of breast abdomen side of body rib, and it is demented to lose the heart, and the calentura coma is spitted blood epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, jaundice.Select for use Rhizoma Corydalis to be because its nature and flavor are arduous, temperature is gone into liver, spleen channel, invigorate blood circulation, and promoting the circulation of QI, the analgesic function is controlled the breast side of body, epigastric pain, the amenorrhea dysmenorrhea, postpartum stagnation, tumbling down swells and ache.Select the Radix Paeoniae Alba for use, the different name Radix Paeoniae Alba is that liver, spleen channel are gone in cold, and nourishing blood to suppress the hyperactive liver is arranged because of its nature and flavor picric acid, slow middle pain relieving, and yin fluid astringing is received the function of antiperspirant, controls the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Selecting Herba Lysimachiae for use is that cold has heat clearing away because of its nature and flavor toil, diuresis, and antitussive, detumescence, the antidotal function, the subcutaneous ulcer of harnessing the Yellow River, edema, vesical calculus, malaria, lung abscess, stranguria with turbid discharge, leukorrhagia, rheumatic arthralgia, infantile malnutrition , Jing Epilepsy, carbuncle, skin ulcer tinea, eczema are spitted blood in cough.Select for use Cera Chinensis to be because its nature and flavor are sweet, temperature is gone into Liver Channel, and hemostasis is arranged, granulation promoting, and the function of analgesic therapy, it is hemorrhage to control incised wound, and hematuria, hematochezia, skin infection are burst for a long time and are not held back primary sore.Select Radix Notoginseng for use, the different name Radix Notoginseng is that temperature is gone into liver, stomach, large intestine channel, and hemostasis is arranged because of its property sweet and slightly bitter taste, dissipating blood stasis, detumescence, the function of analgesic therapy is controlled haematemesis, hemoptysis, and epistaxis is had blood in stool, dysentery, metrorrhagia mass in the abdomen, puerperal blood faints, retention of lochia falls and pounces on blood stasis, traumatic hemorrhage, carbuncle pain.Select for use Rhizoma Alismatis to be because its nature and flavor are sweet, cold, go into kidney, urinary bladder channel, diuretic is arranged, eliminating dampness by diuresis, the function that expels the heat-evil is controlled dysuria, edema distension, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.Select for use Poria to be because its property slightly sweet flavor is flat, go into the heart, spleen, lung meridian, eliminating dampness and diuresis is arranged, the strengthening the spleen stomach function regulating, the function of mind tranquilizing and the heart calming is controlled dysuria, the edema distension, the phlegm retention cough with dyspnea, the sound of vomiting of vomitting is had loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful.Select for use Poria cum Radix Pini to be because its property slightly sweet flavor is flat, go into the heart, spleen channel, mind calming is arranged, calm the nerves, the function of diuretic is controlled the palpitation with fear of having a guilty conscience, and is forgetful, insomnia, frightened Epilepsy, dysuria.Select for use Chrysomyiame gacephala (Fab.) to be because its nature and flavor are salty, cold, go into spleen, stomach warp, heat clearing away is arranged, the stagnant function that disappears is controlled infantile malnutrition abdominal distention, chancre.Select for use Radix Ampelopsis to be because its property bitter but sweet flavor is flat, the heart, liver, spleen channel are gone in cold, and heat clearing away is arranged, detoxifcation, and eliminating stagnation, granulation promoting, the analgesic function is controlled carbuncle, furuncle, scrofula is scalded, pyrexial malaria, frightened Epilepsy, dysentery, hemorrhoidal hamorrhage, anal fistula.Select for use Herba Agrimoniae to be because its nature and flavor toil is flat, go into lung, liver, spleen channel, hemostasis is arranged, the function that is good for the stomach is controlled spitting of blood, spits blood, and hematuria is had blood in stool, dysentery, and bleeding not during menses, impairment caused by overstrain is taken off power, carbuncle, traumatic injury, wound hemorrhage.Select for use Radix Sanguisorbae to be because its nature and flavor picric acid is cold, go into liver, large intestine channel, cooling blood for hemostasis is arranged, the function of heat-clearing and toxic substances removing is controlled haematemesis, epistaxis, dysentery, metrorrhagia, hemorrhoidal hamorrhage, anal fistula, carbuncle, eczema, incised wound, burn.Select for use Rhizoma Polygoni Cuspidati to be because its nature and flavor hardship is flat, dispel the wind, dampness removing, removing blood stasis with potent drugs, the function of stimulating the menstrual flow, the dispelling the wind and dampness pathogens bones and muscles pain, jaundice due to damp-heat, the stranguria with turbid discharge leukorrhagia, women's amenorrhea, lochiostasis , lumps in the chest and abdomen, the anal fistula hematochezia, injury from falling down is scalded malignant boil tinea disease.Selecting Fructus Anisi Stellati for use is that temperature is gone into spleen, kidney channel, and warming YANG is arranged because of its property acrid-sweet flavor, cold expelling, and the function of regulating the flow of vital energy is controlled the invasion by pathogenic cold vomiting, colic of cold type stomachache, lumbago due to renal deficiency, dried, beriberi caused by pathogenic damp.Selecting Semen Alpiniae Katsumadai for use is that temperature is gone into spleen, stomach warp, and warming middle-JIAO is arranged because of its nature and flavor suffering, cold relieving, and sector-style, the function of dampness is controlled trusted subordinate's cold type of pain, the feeling of fullness dyspepsia, dysphagia and regurgitation, cold-damp is vomited and diarrhoea, and phlegm retention is gathered.Selecting Semen Myristicae for use is that temperature is gone into spleen, large intestine channel, and warming middle-JIAO is arranged because of its nature and flavor suffering, and the therapeutic method to keep the adverse QI flowing downwards helps digestion, Gu the function of intestinal is controlled trusted subordinate's distending pain, and the diarrhea of deficiency type cold-dysentery, vomiting, dyspepsia does not disappear.Selecting Fructus Amomi Rotundus for use is because its nature and flavor suffering, and temperature is gone into lung, spleen channel, and circulation of qi promoting is arranged, and warming the stomach helps digestion, and the function of alleviating distention in middle-JIAO is controlled the stagnation of QI, and dyspepsia is uncomfortable in chest, abdominal distention, eructation, dysphagic, tell contrary, regurgitation, malaria.Select for use Endoconcha Sepiae to be because its nature and flavor are salty, tepor is gone into liver, kidney channel, and dehumidifying is arranged, antacid, and the function of skin ulcer is held back in hemostasis, and the acid regurgitation that treats for stomachache is told, nosebleed, hematemesis, has blood in stool, bleeding not during menses, amenorrhea due to blood depletion, Fu Tong mass in the abdomen, the intermittent fever of deficiency type dysentery, skin ulcer is rotted in the erosion of the vulva.Selecting Herba Pogostemonis for use is because its nature and flavor suffering, and tepor is gone into lung, spleen, stomach warp, have fast gas and in, ward off dirty, the function of damp eliminating, the heat-damp in summer that cures cold, cold and heat, headache, breast gastral cavity painful abdominal mass is vexed, vomiting is had loose bowels, malaria, dysentery, halitosis.Selecting Herba Eupatorii for use is because its nature and flavor suffering, flat, goes into spleen, stomach warp, and clearing away summer-heat is arranged, ward off dirty, removing dampness, the effect of regulating menstruation is controlled and is experienced heat-damp in summer, the cold and heat headache is accumulate in the damp, the gastral cavity painful abdominal mass is not hungry, sweet taste in the mouth greasy fur, menoxenia.
The specific embodiment
The drug dose of the present invention's combination also is that the inventor draws through groping in a large number to sum up, and the consumption of each grouping all has better curative effect in following weight range:
Fructus Amomi 6-15 gram Radixs Angelicae Dahuricae 8-15 gram Pericarpium Citri Reticulataes 10-15 grams
Fructus Foeniculi 10-30 gram Pseudobulbus Bletillae (Rhizoma Bletillae) 6-15 gram Galla Chinensiss 6-12 grams
Fructus Schisandrae Chinensis 6-15 gram Pericarpium Citri Reticulatae Virides 10-15 gram Radix Curcumaes 10-15 grams
Rhizoma Corydalis 10-15 gram Radix Paeoniae Albas 10-15 gram Herba Lysimachiaes 15-30 grams
Cera Chinensis 3-6 gram Radix Notoginseng 6-12 gram Rhizoma Alismatis 10-15 grams
Poria 15-20 gram Poria cum Radix Pinis 10-20 gram Chrysomyiame gacephala (Fab.) 6-10 grams
Radix Ampelopsis 6-10 gram Herba Agrimoniaes 8-15 gram Radix Sanguisorbaes 10-20 grams
Rhizoma Polygoni Cuspidati 10-15 gram Fructus Anisi Stellatis 5-10 gram Semen Alpiniae Katsumadai 3-8 grams
Semen Myristicae 3-8 gram Fructus Amomi Rotunduss 3-8 gram Endoconcha Sepiaes 6-15 grams
Herba Pogostemonis 10-20 gram Herba Eupatoriis 10-20 grams
Be preferably:
The Fructus Amomi 10 gram Radixs Angelicae Dahuricae 10 gram Pericarpium Citri Reticulataes 12 grams
Fructus Foeniculi 20 gram Pseudobulbus Bletillae (Rhizoma Bletillae) 12 gram Galla Chinensiss 8 grams
Fructus Schisandrae Chinensis 10 gram Pericarpium Citri Reticulatae Virides 12 gram Radix Curcumaes 12 grams
The Rhizoma Corydalis 12 gram Radix Paeoniae Albas 12 gram Herba Lysimachiaes 20 grams
Cera Chinensis 4 gram Radix Notoginseng 7 gram Rhizoma Alismatis 12 grams
Poria 15 gram Poria cum Radix Pinis 15 gram Chrysomyiame gacephala (Fab.) 8 grams
Radix Ampelopsis 8 gram Herba Agrimoniaes 12 gram Radix Sanguisorbaes 15 grams
Rhizoma Polygoni Cuspidati 12 gram Fructus Anisi Stellatis 8 gram Semen Alpiniae Katsumadai 6 grams
Semen Myristicae 6 gram Fructus Amomi Rotunduss 6 gram Endoconcha Sepiaes 12 grams
Herba Pogostemonis 15 gram Herba Eupatoriis 15 grams
The preparation method of medicine of the present invention is as follows
One, gets the raw materials ready
1, Fructus Amomi: remove impurity and shell, smash to pieces;
2, the Radix Angelicae Dahuricae: choose decontamination, wash, soak, pull out and run through, slightly shine when crust does not have soapy feeling, again behind the moistening, chip drying;
3, Pericarpium Citri Reticulatae: get crude drug, remove the peel of impurity and blackening, wash quickly is clean, moistens softly, and shredding is dried or cold drying, and sieve removes chip;
4, Fructus Foeniculi: get crude drug, remove impurity;
5, Pseudobulbus Bletillae (Rhizoma Bletillae): choose decontamination, be soaked in water, pull out, it is suitable to humidity to dry in the air, section, drying;
6, Galla Chinensis: choose clean, knock, remove wherein impurity open;
7, Fructus Schisandrae Chinensis: sieve dedust bits, remove impurity, to put in the food steamer and steam thoroughly, taking-up is dried;
8, Pericarpium Citri Reticulatae Viride: choose clean impurity, be soaked in water, pull out, run through, section is dried;
9, Radix Curcumae: be soaked in water, pull out to shine and dry in the air, run through, section is dried;
10, Rhizoma Corydalis: get Rhizoma Corydalis and mix infiltration thoroughly, exhaust to vinegar, put to fry in the pot and do, rare black speck, 100 jin of every Rhizoma Corydalis, 20 jin of vinegar with vinegar;
11, the Radix Paeoniae Alba: fry together with Testa Tritici, be yellow or buff to the surface, take out, sieve removes Testa Tritici, spreading for cooling;
12, Herba Lysimachiae: choose clean impurity, dry;
13, Cera Chinensis: select the high-quality medical material, it is standby to be ground into powder;
14, Radix Notoginseng: choose most impurity, smash to pieces, grind or run through section into powder and dry;
15, Rhizoma Alismatis: choose decontamination, big or small stepping is soaked in water, and pulls out thoroughly to eighty per cant, and solarization is dried in the air, and moistening is even to inside and outside humidity, and section is dried;
16, Poria: be soaked in water, clean, pull out, vexed after, cut into slices, dry;
17, Poria cum Radix Pini: select the high-quality sheet, sieve dedust soil;
18, Chrysomyiame gacephala (Fab.): choose clean impurity, the clean earth of winnowing with a dustpan, levigation is standby;
19, Radix Ampelopsis: remove stem and thin fibrous root, clean, cut off, dry;
20, Herba Agrimoniae: remove the impurity undesirable root, clean, run through, cut off, dry;
21, Radix Sanguisorbae: get the Radix Sanguisorbae sheet and put to fry in the pot to appearance and become black, inner strong yellow sprays clear water, takes out, and dries;
22, Rhizoma Polygoni Cuspidati: get the Rhizoma Polygoni Cuspidati root, smooth file is but wrapped up in a night with Folium Polygoni Cuspidati, goes out, and dries usefulness;
23, Fructus Anisi Stellati: sieve removes the spare seed, chooses fruit stem impurity, inserts to fry in the pot and sees black speck to the surface;
24, Semen Alpiniae Katsumadai: choose clean impurity, shell and get core, the time spent smashs to pieces;
25, Semen Myristicae: clean, get flour and add water and rub up parcel;
26, Fructus Amomi Rotundus: choose clean impurity, the sieve scurf removing is smashed, or is peelled off shell, gets core and smashes usefulness;
27, Endoconcha Sepiae: scrub clean, dry, pound into fritter;
28, Herba Pogostemonis: choose decontamination, remove undesirable root and old stem, leaf is taken in addition put earlier, the stem water runs through, and cutting is dried, then with leaf and even;
29, Herba Eupatorii: choose clean impurity, wash, pull out, after the profit, remove undesirable root slightly, cutting is dried.
Two, preparation
1, the preparation of capsule:
Fructus Amomi with described weight, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Fructus Foeniculi, Pseudobulbus Bletillae (Rhizoma Bletillae), Galla Chinensis, Fructus Schisandrae Chinensis, Pericarpium Citri Reticulatae Viride, Radix Curcumae, Rhizoma Corydalis, the Radix Paeoniae Alba, Herba Lysimachiae, Cera Chinensis, Radix Notoginseng, Rhizoma Alismatis, Poria, Poria cum Radix Pini, Chrysomyiame gacephala (Fab.), Radix Ampelopsis, Herba Agrimoniae, Radix Sanguisorbae, Rhizoma Polygoni Cuspidati, Fructus Anisi Stellati, Semen Alpiniae Katsumadai, Semen Myristicae, Fructus Amomi Rotundus, Endoconcha Sepiae, Herba Pogostemonis, Herba Eupatorii decocts with water twice, each amount of water is advisable to cover powder, merge decoction liquor twice, it is 1.35 extractum that filtering and concentrating becomes proportion, add 90-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and be concentrated in 45-50 ℃ of dryings down, it is ground into powder, incapsulates.
2, the preparation of tablet:
Fructus Amomi with described weight, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Fructus Foeniculi, Pseudobulbus Bletillae (Rhizoma Bletillae), Galla Chinensis, Fructus Schisandrae Chinensis, Pericarpium Citri Reticulatae Viride, Radix Curcumae, Rhizoma Corydalis, the Radix Paeoniae Alba, Herba Lysimachiae, Cera Chinensis, Radix Notoginseng, Rhizoma Alismatis, Poria, Poria cum Radix Pini, Chrysomyiame gacephala (Fab.), Radix Ampelopsis, Herba Agrimoniae, Radix Sanguisorbae, Rhizoma Polygoni Cuspidati, Fructus Anisi Stellati, Semen Alpiniae Katsumadai, Semen Myristicae, Fructus Amomi Rotundus, Endoconcha Sepiae, Herba Pogostemonis, Herba Eupatorii decocts with water twice, add for the first time 6 times of amounts of water, decocted 1.5 hours, add for the second time 4 times of amounts of water, decocted 1 hour, merge the extractum that twice decoction liquor is condensed into proportion 1.35, extractum added 90-95% ethanol, stir precipitation and reclaim ethanol and concentrated, dry down at 45 ℃-50 ℃, be ground into powder, add the adjuvant compacting in flakes.
3, the preparation of decocting liquid:
(1) Fructus Amomi, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Fructus Foeniculi, Pseudobulbus Bletillae (Rhizoma Bletillae), Galla Chinensis, Fructus Schisandrae Chinensis, Pericarpium Citri Reticulatae Viride, Radix Curcumae, Rhizoma Corydalis, the Radix Paeoniae Alba, Herba Lysimachiae, Cera Chinensis, Radix Notoginseng, Rhizoma Alismatis, Poria, Poria cum Radix Pini, Chrysomyiame gacephala (Fab.), Radix Ampelopsis, Herba Agrimoniae, Radix Sanguisorbae, Rhizoma Polygoni Cuspidati, Fructus Anisi Stellati, Semen Alpiniae Katsumadai, Semen Myristicae, Fructus Amomi Rotundus, Endoconcha Sepiae, Herba Pogostemonis, the Herba Eupatorii with described weight decocts with water, add for the first time 2 times of amounts of water, intense fire decocts boiling 30 minutes, promptly decoction liquor was the liquid of taking medicine patient's morning for the first time in 20 minutes in the reuse slow fire boiling.
(2) medicinal residues after will filtering for the first time add 1.5 times of amounts of water, decoct boiling, and the reuse slow fire boiling promptly get the decoction liquor second time in 20 minutes, the liquid of taking medicine the evening that is the patient.
4, particulate preparation:
Fructus Amomi with described weight, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Fructus Foeniculi, Pseudobulbus Bletillae (Rhizoma Bletillae), Galla Chinensis, Fructus Schisandrae Chinensis, Pericarpium Citri Reticulatae Viride, Radix Curcumae, Rhizoma Corydalis, the Radix Paeoniae Alba, Herba Lysimachiae, Cera Chinensis, Radix Notoginseng, Rhizoma Alismatis, Poria, Poria cum Radix Pini, Chrysomyiame gacephala (Fab.), Radix Ampelopsis, Herba Agrimoniae, Radix Sanguisorbae, Rhizoma Polygoni Cuspidati, Fructus Anisi Stellati, Semen Alpiniae Katsumadai, Semen Myristicae, Fructus Amomi Rotundus, Endoconcha Sepiae, Herba Pogostemonis, Herba Eupatorii decocts with water twice, add for the first time 6 times of amounts of water, decocted 1.5 hours, add for the second time 4 times of amounts of water, decocted 1 hour, merging twice decoction liquor, to be condensed into proportion be 1.35 extractum, extractum added 90-95% ethanol, stir precipitation and reclaim ethanol and concentrated, dry down at 45 ℃-50 ℃, add adjuvant, make granule.
5, the preparation of unguentum:
Fructus Amomi, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Fructus Foeniculi, Pseudobulbus Bletillae (Rhizoma Bletillae), Galla Chinensis, Fructus Schisandrae Chinensis, Pericarpium Citri Reticulatae Viride, Radix Curcumae, Rhizoma Corydalis, the Radix Paeoniae Alba, Herba Lysimachiae, Cera Chinensis, Radix Notoginseng, Rhizoma Alismatis, Poria, Poria cum Radix Pini, Chrysomyiame gacephala (Fab.), Radix Ampelopsis, Herba Agrimoniae, Radix Sanguisorbae, Rhizoma Polygoni Cuspidati, Fructus Anisi Stellati, Semen Alpiniae Katsumadai, Semen Myristicae, Fructus Amomi Rotundus, Endoconcha Sepiae, Herba Pogostemonis, the Herba Eupatorii of described weight are decocted with water twice, add for the first time 6 times of amounts of water, decocted 1.5 hours, add for the second time 4 times of amounts of water, decocted 1 hour, merging twice decoction liquor, to be condensed into proportion be 1.35 extractum.
The active component of medicine of the present invention can add preparation required various conventional adjuvant during different dosage form, is prepared into any peroral dosage form commonly used with the method for Chinese medicinal of routine, as tablet, capsule, oral agents, granule, unguentum etc.
Medicine of the present invention has invigorating the spleen and regulating the stomach, the dampness of regulating the flow of vital energy, and the heat clearing away eliminating dampness by diuresis, nourishing the stomach is good for the stomach, and granulation promoting is put on flesh, putrefaction removing and tissue regeneration promoting, the effect that hemostasis is nourished blood is used for the treatment of stomach, duodenal ulcer etc., and curative effect is fast, easily radical cure.Below further set forth effective achievement of medicine of the present invention by testing example, these tests comprise that medicine of the present invention (hereinafter to be referred as the quick-acting health of ulcer) animal toxicity test and clinical observation test.
[test example 1] medicine of the present invention is to the toxicity test report of rabbit
Get 40 of West Germany does, body weight 2.0-2.5kg divides two groups, every group 20, wherein one group is the overdose test group, and another group is the normal amount test group, the super quantity group is 20ml/kg, normal amount is 10ml/kg, and administering mode is the administration by gavage administration, once a day, serve on January, observe the administration reaction every day, the result shows two groups of rabbit activities, comprises normally, and medicine does not have bad toxic and side effects.
The clinical observation material of [test example 2] medicine of the present invention
1, physical data:
Accept out-patient's 1800 examples for medical treatment, 30-40 years old 1200 age example, 40-60 years old 500 example, 100 examples more than 60 years old.
2, diagnostic criteria:
Light-duty stomach, duodenal ulcer 3-5 years, patient's diet is relatively poor, epigastric distension and distress, bitter taste in the mouth and dry throat has vomiting and nausea distending pain or twinge during halitosis, find to have slight ulcer through shellfish meal perspective or gastroscopy.
Heavy stomach, duodenal ulcer disease history 5-10 years, patient's emaciation and sallow complexion, extremity are tired, and work gastral cavilty portion pain increases the weight of, and melena, yellowish or reddish urine etc. appear in stool often, and shellfish meal or gastroscopy find to have large tracts of land ulcer in various degree.
3, Therapeutic Method:
Decocting liquid: by measuring the quick-acting health of ulcer, put into the container herbal decoction routinely of boiling medicine, sooner or later service once every day twice, ten days is a course of treatment, a light-duty course of treatment, heavy two courses of treatment.
Tablet: oral three times of every day, each 8, ten days is a course of treatment, a light-duty course of treatment, heavy two courses of treatment.
Capsule: oral three times of every day, each 12, ten days is a course of treatment, a light-duty course of treatment, heavy two courses of treatment.
Granule: oral three times of every day, each 1 bag (9g), ten days is a course of treatment, a light-duty course of treatment, heavy two courses of treatment.
Unguentum: oral three times of every day, each ml, ten days is a course of treatment, a light-duty course of treatment, heavy two courses of treatment.
4, efficacy assessment standard:
Produce effects: light, heavy stomach, duodenal ulcer disease this disease symptoms of patient after treating disappears, and it is normal that patient's body constitution is recovered, and 1-3 years no recidivists are followed up a case by regular visits in shellfish meal or the healing of gastroscopy ulcer place.
Take a turn for the better: stomach, duodenal ulcer symptom progressively alleviate or disappear, and the patient feels good, and it is normal that body constitution is recovered substantially.
Invalid: as not reach improvement standard person.
5, therapeutic outcome: (seeing the following form)
In the treatment of a course of treatment, with the light-duty stomach of Drug therapy of the present invention, duodenal ulcer patients 1600 examples, produce effects 1580 examples, 20 examples that take a turn for the better, total effective rate 100%; In the treatment of two courses of treatment, with the heavy stomach of Drug therapy of the present invention, duodenal ulcer patients 200 examples, produce effects 149 examples, 51 examples that take a turn for the better, total effective rate is 100%.

Claims (3)

1. a medicine for the treatment of gastric and duodenal ulcers is characterized in that, it is to be made by the crude drug in the following weight scope:
Fructus Amomi 6-15 gram Radixs Angelicae Dahuricae 8-15 gram Pericarpium Citri Reticulataes 10-15 grams
Fructus Foeniculi 10-30 gram Pseudobulbus Bletillae (Rhizoma Bletillae) 6-15 gram Galla Chinensiss 6-12 grams
Fructus Schisandrae Chinensis 6-15 gram Pericarpium Citri Reticulatae Virides 10-15 gram Radix Curcumaes 10-15 grams
Rhizoma Corydalis 10-15 gram Radix Paeoniae Albas 10-15 gram Herba Lysimachiaes 15-30 grams
Cera Chinensis 3-6 gram Radix Notoginseng 6-12 gram Rhizoma Alismatis 10-15 grams
Poria 15-20 gram Poria cum Radix Pinis 10-20 gram Chrysomyiame gacephala (Fab.) 6-10 grams
Radix Ampelopsis 6-10 gram Herba Agrimoniaes 8-15 gram Radix Sanguisorbaes 10-20 grams
Rhizoma Polygoni Cuspidati 10-15 gram Fructus Anisi Stellatis 5-10 gram Semen Alpiniae Katsumadai 3-8 grams
Semen Myristicae 3-8 gram Fructus Amomi Rotunduss 3-8 gram Endoconcha Sepiaes 6-15 grams
Herba Pogostemonis 10-20 gram Herba Eupatoriis 10-20 grams.
2. medicine according to claim 1 is characterized in that: wherein the consumption of each crude drug is:
The Fructus Amomi 10 gram Radixs Angelicae Dahuricae 10 gram Pericarpium Citri Reticulataes 12 grams
Fructus Foeniculi 20 gram Pseudobulbus Bletillae (Rhizoma Bletillae) 12 gram Galla Chinensiss 8 grams
Fructus Schisandrae Chinensis 10 gram Pericarpium Citri Reticulatae Virides 12 gram Radix Curcumaes 12 grams
The Rhizoma Corydalis 12 gram Radix Paeoniae Albas 12 gram Herba Lysimachiaes 20 grams
Cera Chinensis 4 gram Radix Notoginseng 7 gram Rhizoma Alismatis 12 grams
Poria 15 gram Poria cum Radix Pinis 15 gram Chrysomyiame gacephala (Fab.) 8 grams
Radix Ampelopsis 8 gram Herba Agrimoniaes 12 gram Radix Sanguisorbaes 15 grams
Rhizoma Polygoni Cuspidati 12 gram Fructus Anisi Stellatis 8 gram Semen Alpiniae Katsumadai 6 grams
Semen Myristicae 6 gram Fructus Amomi Rotunduss 6 gram Endoconcha Sepiaes 12 grams
Herba Pogostemonis 15 gram Herba Eupatoriis 15 grams.
3. according to the preparation method of claim 1 or 2 described medicines, it is characterized in that: it comprises the following steps:
(1) gets the raw materials ready
(1) Fructus Amomi: remove impurity and shell, smash to pieces;
(2) Radix Angelicae Dahuricae: choose decontamination, wash, soak, pull out and run through, slightly shine when crust does not have soapy feeling, again behind the moistening, chip drying;
(3) Pericarpium Citri Reticulatae: get crude drug, remove the peel of impurity and blackening, wash quickly is clean, moistens softly, and shredding is dried or cold drying, and sieve removes chip;
(4) Fructus Foeniculi: get crude drug, remove impurity;
(5) Pseudobulbus Bletillae (Rhizoma Bletillae): choose decontamination, be soaked in water, pull out, it is suitable to humidity to dry in the air, section, drying;
(6) Galla Chinensis: choose clean, knock, remove wherein impurity open;
(7) Fructus Schisandrae Chinensis: sieve dedust bits, remove impurity, to put in the food steamer and steam thoroughly, taking-up is dried;
(8) Pericarpium Citri Reticulatae Viride: choose clean impurity, be soaked in water, pull out, run through, section is dried;
(9) Radix Curcumae: be soaked in water, pull out to shine and dry in the air, run through, section is dried;
(10) Rhizoma Corydalis: get Rhizoma Corydalis and mix infiltration thoroughly, exhaust to vinegar, put to fry in the pot and do, rare black speck, 100 jin of every Rhizoma Corydalis, 20 jin of vinegar with vinegar;
(11) Radix Paeoniae Alba: fry together with Testa Tritici, be yellow or buff to the surface, take out, sieve removes Testa Tritici, spreading for cooling;
(12) Herba Lysimachiae: choose clean impurity, dry;
(13) Cera Chinensis: select the high-quality medical material, it is standby to be ground into powder;
(14) Radix Notoginseng: choose most impurity, smash to pieces, grind or run through section into powder and dry;
(15) Rhizoma Alismatis: choose decontamination, big or small stepping is soaked in water, and pulls out thoroughly to eighty per cant, and solarization is dried in the air, and moistening is even to inside and outside humidity, and section is dried;
(16) Poria: be soaked in water, clean, pull out, vexed after, cut into slices, dry;
(17) Poria cum Radix Pini: select the high-quality sheet, sieve dedust soil;
(18) Chrysomyiame gacephala (Fab.): choose clean impurity, the clean earth of winnowing with a dustpan, levigation is standby;
(19) Radix Ampelopsis: remove stem and thin fibrous root, clean, cut off, dry;
(20) Herba Agrimoniae: remove the impurity undesirable root, clean, run through, cut off, dry;
(21) Radix Sanguisorbae: get the Radix Sanguisorbae sheet and put to fry in the pot to appearance and become black, inner strong yellow sprays clear water, takes out, and dries;
(22) Rhizoma Polygoni Cuspidati: get polygoni cuspidati,radix, smooth file is but wrapped up in a night with Folium Polygoni Cuspidati, goes out, and dries usefulness;
(23) Fructus Anisi Stellati: sieve removes the spare seed, chooses fruit stem impurity, inserts to fry in the pot and sees black speck to the surface;
(24) Semen Alpiniae Katsumadai: choose clean impurity, shell and get core, the time spent smashs to pieces;
(25) Semen Myristicae: clean, get flour and add water and rub up parcel;
(26) Fructus Amomi Rotundus: choose clean impurity, the sieve scurf removing is smashed, or is peelled off shell, gets core and smashes usefulness;
(27) Endoconcha Sepiae: scrub clean, dry, pound into fritter;
(28) Herba Pogostemonis: choose decontamination, remove undesirable root and old stem, leaf is taken in addition put earlier, the stem water runs through, and cutting is dried, then with leaf and even;
(29) Herba Eupatorii: choose clean impurity, wash, pull out, after the profit, remove undesirable root slightly, cutting is dried;
(2) preparation
(1) preparation of capsule:
Fructus Amomi with described weight, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Fructus Foeniculi, Pseudobulbus Bletillae (Rhizoma Bletillae), Galla Chinensis, Fructus Schisandrae Chinensis, Pericarpium Citri Reticulatae Viride, Radix Curcumae, Rhizoma Corydalis, the Radix Paeoniae Alba, Herba Lysimachiae, Cera Chinensis, Radix Notoginseng, Rhizoma Alismatis, Poria, Poria cum Radix Pini, Chrysomyiame gacephala (Fab.), Radix Ampelopsis, Herba Agrimoniae, Radix Sanguisorbae, Rhizoma Polygoni Cuspidati, Fructus Anisi Stellati, Semen Alpiniae Katsumadai, Semen Myristicae, Fructus Amomi Rotundus, Endoconcha Sepiae, Herba Pogostemonis, Herba Eupatorii decocts with water twice, each amount of water is advisable to cover powder, merge decoction liquor twice, it is 1.35 extractum that filtering and concentrating becomes proportion, add 90-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and be concentrated in 45-50 ℃ of dryings down, it is ground into powder, incapsulates;
(2) preparation of tablet:
Fructus Amomi with described weight, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Fructus Foeniculi, Pseudobulbus Bletillae (Rhizoma Bletillae), Galla Chinensis, Fructus Schisandrae Chinensis, Pericarpium Citri Reticulatae Viride, Radix Curcumae, Rhizoma Corydalis, the Radix Paeoniae Alba, Herba Lysimachiae, Cera Chinensis, Radix Notoginseng, Rhizoma Alismatis, Poria, Poria cum Radix Pini, Chrysomyiame gacephala (Fab.), Radix Ampelopsis, Herba Agrimoniae, Radix Sanguisorbae, Rhizoma Polygoni Cuspidati, Fructus Anisi Stellati, Semen Alpiniae Katsumadai, Semen Myristicae, Fructus Amomi Rotundus, Endoconcha Sepiae, Herba Pogostemonis, Herba Eupatorii decocts with water twice, add for the first time 6 times of amounts of water, decocted 1.5 hours, add for the second time 4 times of amounts of water, decocted 1 hour, merge the extractum that twice decoction liquor is condensed into proportion 1.35, extractum added 90-95% ethanol, stir precipitation and reclaim ethanol and concentrated, dry down at 45 ℃-50 ℃, be ground into powder, add the adjuvant compacting in flakes;
(3) preparation of decocting liquid:
1. Fructus Amomi, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Fructus Foeniculi, Pseudobulbus Bletillae (Rhizoma Bletillae), Galla Chinensis, Fructus Schisandrae Chinensis, Pericarpium Citri Reticulatae Viride, Radix Curcumae, Rhizoma Corydalis, the Radix Paeoniae Alba, Herba Lysimachiae, Cera Chinensis, Radix Notoginseng, Rhizoma Alismatis, Poria, Poria cum Radix Pini, Chrysomyiame gacephala (Fab.), Radix Ampelopsis, Herba Agrimoniae, Radix Sanguisorbae, Rhizoma Polygoni Cuspidati, Fructus Anisi Stellati, Semen Alpiniae Katsumadai, Semen Myristicae, Fructus Amomi Rotundus, Endoconcha Sepiae, Herba Pogostemonis, the Herba Eupatorii with described weight decocts with water, add for the first time 2 times of amounts of water, intense fire decocts boiling 30 minutes, promptly decoction liquor was the liquid of taking medicine patient's morning for the first time in 20 minutes in the reuse slow fire boiling;
2. the medicinal residues after will filtering for the first time add 1.5 times of amounts of water, decoct boiling, and the reuse slow fire boiling promptly get the decoction liquor second time in 20 minutes, the liquid of taking medicine the evening that is the patient;
(4) particulate preparation:
Fructus Amomi with described weight, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Fructus Foeniculi, Pseudobulbus Bletillae (Rhizoma Bletillae), Galla Chinensis, Fructus Schisandrae Chinensis, Pericarpium Citri Reticulatae Viride, Radix Curcumae, Rhizoma Corydalis, the Radix Paeoniae Alba, Herba Lysimachiae, Cera Chinensis, Radix Notoginseng, Rhizoma Alismatis, Poria, Poria cum Radix Pini, Chrysomyiame gacephala (Fab.), Radix Ampelopsis, Herba Agrimoniae, Radix Sanguisorbae, Rhizoma Polygoni Cuspidati, Fructus Anisi Stellati, Semen Alpiniae Katsumadai, Semen Myristicae, Fructus Amomi Rotundus, Endoconcha Sepiae, Herba Pogostemonis, Herba Eupatorii decocts with water twice, add for the first time 6 times of amounts of water, decocted 1.5 hours, add for the second time 4 times of amounts of water, decocted 1 hour, merging twice decoction liquor, to be condensed into proportion be 1.35 extractum, extractum added 90-95% ethanol, stir precipitation and reclaim ethanol and concentrated, dry down at 45 ℃-50 ℃, add adjuvant, make granule;
(5) preparation of unguentum:
Fructus Amomi, the Radix Angelicae Dahuricae, Pericarpium Citri Reticulatae, Fructus Foeniculi, Pseudobulbus Bletillae (Rhizoma Bletillae), Galla Chinensis, Fructus Schisandrae Chinensis, Pericarpium Citri Reticulatae Viride, Radix Curcumae, Rhizoma Corydalis, the Radix Paeoniae Alba, Herba Lysimachiae, Cera Chinensis, Radix Notoginseng, Rhizoma Alismatis, Poria, Poria cum Radix Pini, Chrysomyiame gacephala (Fab.), Radix Ampelopsis, Herba Agrimoniae, Radix Sanguisorbae, Rhizoma Polygoni Cuspidati, Fructus Anisi Stellati, Semen Alpiniae Katsumadai, Semen Myristicae, Fructus Amomi Rotundus, Endoconcha Sepiae, Herba Pogostemonis, the Herba Eupatorii of described weight are decocted with water twice, add for the first time 6 times of amounts of water, decocted 1.5 hours, add for the second time 4 times of amounts of water, decocted 1 hour, merging twice decoction liquor, to be condensed into proportion be 1.35 extractum.
CN2010105449574A 2010-11-16 2010-11-16 Medicine for treating gastric ulcer and duodenal ulcer and preparation method thereof Expired - Fee Related CN101983716B (en)

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