CN105983058A - Traditional Chinese medicine granule for treating tuberculosis - Google Patents

Abstract

A traditional Chinese medicine granule for treating tuberculosis is prepared through the steps of: 1) preparing raw materials including 20 parts of dandelion, 8 parts of platycodon grandiflorum and 10 parts of codonopsis pilosula, performing reflux extraction to the raw materials with 70% ethanol for 120 min, filtering the medicine liquid and recycling the ethanol, and concentrating the extract liquid into clear paste until the specific gravity is 1:1.05; 2) steaming 10 parts of bletilla striata, cutting the bletilla striata into slices, drying the bletilla striata with 8 parts of radix pseudostellariae, 20 parts of ranunculus ternatus, 8 parts of pseudo-ginseng and 8 parts of honeysuckles, crushing the mixture into coarse powder, mixing the coarse powder with 8 parts of cane sugar, drying the mixture and pulverizing the mixture into fine powder; and 3) mixing the fine powder with the clear paste to prepare a soft material, and granulating the soft material through a one-step granulation fluidized drier, and packaging the granules by 5 g per bag. The granule is used for treating the tuberculosis with the dosage being 1 bag per time, wherein the granule is brewed in hot water for 5 min and is orally taken. The granule is taken by 5 g (1 bag) per time for 3 times per day and is continuously taken for more than 10 weeks.

Description

One treats Chinese medicine granules lungy

1 art

The present invention relates to one and treat Chinese medicinal formulae lungy, be with 8 taste Chinese medicines and refined and obtain, to lung knot by modern technologies Core disease has health protection and therapeutic action, the invention belongs to traditional Chinese medicine preparation field.

2 background technologies

The discussion to pulmonary tuberculosis of 2.1 modern medicines

Pulmonary tuberculosis (Pulmonuny tuberculosis) is the chronic lung infection disease that mycobacterium tuberculosis causes, and accounts for each The 80%-90% of organ tuberculosis sum, wherein apoplexy due to phlegm excreter is referred to as infectiousness pulmonary tuberculosis.

Source of disease: tulase belongs to Actinomycetal, mycobacteriaceae, Mycobacterium on taxonomy.

The source of infection: the discharge of bacteria of open pulmonary tuberculosis patient is the main source that tulase is propagated.

Route of transmission: the predominantly air-borne transmission between patient and Healthy People.Patient cough discharge tulase be suspended in the spittle In core, infection can be caused after being sucked by people.Susceptible population is for being poorly off, live the social economies such as crowded, malnutrition Fall behind the reason that society's crowd's tuberculosis is occurred frequently.

Pathogenesis: the host response of tubercle bacillus affection and biological process.(1) the initial phase: suck with the small spittle and invade The tulase of respiratory tract is swallowed by pulmonary alveolar macrophage.(2) the t cell responses phase: tulase initial growth in macrophage, Formation center is the tuberculous foci of solid-state cheesy necrosis, and it can limit tulase and continue to replicate.(3) the symbiosis phase.(4) extracellular propagation And propagation periods.

Other tuberculosis: tuberculous peritonitis (tuberculous peritonitis) is the chronic diffusivity caused by tubercule bacillus Peritoneal infection.Tuberculosis of intestine (tuberculous of intestine) is the chronic specific infection that tubercule bacillus invades that intestinal causes, The overwhelming majority is secondary to pulmonary tuberculosis, particularly open pulmonary tuberculosis.Mostly exedens intestinal renal tuberculosis (renal is progressed to Tuberculosis) being a whole body part lungy, to be tubercule bacillus by primary lesioies such as pulmonarys send out to kidney through blood group is drawn Rise.Tuberculous meningitis (tuberculous meningitis) is the meninges nonsuppurative inflammation caused by tubercule bacillus.Skin Tuberculosis (Skin tuberculosis) and bone tuberculosis etc..

Treatment:

(1) chemotherapy.

At present conventional chemicals has: isoniazid, rifampicin, Streptomycin, pyrazinamide, capreomycin, kanamycin, Viomycin etc..

(2) operative treatment.

(3) symptom treatment etc..Country's example enters free treatment disease kind at present.

Tuberculosis is listed in the disease of " pulmonary tuberculosis " by modern Chinese medicine.

Pulmonary tuberculosis is to be corroded the lobe of the lung by consumptive disease worm, and the one caused has communicable chronic kidney disease.Clinically with cough, cough Blood, hectic fever, night sweat, chest pain, health are gradually become thin as principal character.Its pathomechanism is the deficiency of YIN, and pathological changes master is dirty at lung, can Involve spleen kidney, even spread all over the five internal organs and cause the five internal organs loss." consumptive disease ", " biography corpse ", " chronic infectious disease ", " consumptive disease is coughed " in successive dynasties medical book, " acute pulmonary tuberculosis ", " infantile malnutrition complicated by tuberculosis ", " passing corpse to steam " etc. should be for the another names of consumptive disease.

Therapeutic Principle: heat-clearing and toxic substances removing, treating tuberculosis and killing worm, hemostasis and pain-relieving, nourishing YIN and moistening the lung, nourishing kidney pathogenic fire reducing, supplementing QI and nourishing YIN, YIN nourishing is mended Sun, vital base and primordial QI consolidating.

2.3 medicine and pharmacology documents

(1) Chen Haozhu chief editor " practical internal medicine ", ISBN 7-117-04313X, People's Health Publisher publishes, April in 2002 the 11 editions.

(2) Zhou Wenguan etc. compile " newly organized tcm clinical practice handbook " ISBN7-80022-555-0 Golden Shield publishing house JIUYUE the-version in 1993.

(3) Shandong million unicorn etc. the some school towering Wu Jin of Shennong's Herbal etc. state, clearly. and Sun Xing spreads out and collects ISBN7-5381-2560-4 Liaoning medical courses in general skill Art publishing house the-version August in 1997.

(4) cattle accounts for soldier and writes classical Chinese medicine wanted circular Huangdi's Internal Classics ISBN7-5375-1518-8/R-297 Hebei Science Press 1994 March the-version.

(5) clear-Wu Qian etc. compile the Golden Mirror of Medicine ISBN7-117-00728-1/R.729 People's Health Publisher second edition in April nineteen ninety-five

(6) She Jing etc. compile " Chinese medicine modern study and application " ISBN7-5077-1318-0 Xueyuan Press in January, 1998 first edition.

(7) Xie Zongwan chief editor " whole nation Chinese herbal medicine compilation " ISBN7-117-02380-5/8.285, People's Health Publisher in October, 1996 The second edition.

(8) Ding Zhaomeng chief editor " herbal medicine efficacy is with clinical " ISBN7-5067-1925-8/R.285, China Medical Science Press 1999 2 Month the-version.

(9) Liu Guojie edits " pharmaceutics " standard book number: 14048-4693, People's Health Publisher.In February, 1985 second edition；

(10) Fan Biting edits " pharmacy of Chinese materia medica " ISBN7-5323-4439-8/R-1178, January in 1997 the 1st edition.

(11) Li Shizhen (1518-1593 A.D.) compiles the Compendium of Material Medica ISBN7-80568-077-9/R.1 China Book Store Publisher first edition (commercial affairs print in 1988 Book shop version photocopy).

(12) Wang Xiaoming chief editor " Xijing Geriatrics Dept. clinical position handbook " ISBN978-7-5662-0270-3/R.1103 the 4th medical university of army Learn publishing house August in 2012 the 1st edition.

3 summary of the invention

The present invention relates to one and treat Chinese medicinal formulae lungy, according to tcm clinical practice Therapeutic Principle lungy, special prescription and Become, utilize being suitable to take good care for the treatment of for a long time of Chinese medicine and the lighter advantage of side effect and the Chinese medicine of taking convenience.Prescription of the present invention with Technique can be made into granule and may be made as other Chinese medicine preparation Chinese patent medicines such as capsule, pill, tablet.

3.1 formula

Herba Taraxaci 20 parts, Radix Platycodonis 8 parts, Radix Codonopsis 10 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 parts, Radix Pseudostellariae 8 parts, Radix Ranunculi Ternati 20 parts, Radix Notoginseng 8 Part, Flos Lonicerae 8 parts, sucrose (binding agent, sweeting agent) 8 parts.

Note: within every kind of taken amount error when being embodied as should be the 95%-105% of labelled amount.

3.2 technical process

Take Herba Taraxaci 20 parts, Radix Platycodonis 8 parts, Radix Codonopsis 10 parts, with 70% alcohol reflux 120min, leaching medicinal liquid, reclaim Ethanol, extracting solution is condensed into clear paste to proportion 1: 1.05；Pseudobulbus Bletillae (Rhizoma Bletillae) 10 parts is cooked, thinly slices, with Radix Pseudostellariae 8 parts, cat Pawl grass 20 parts, 8 parts of Radix Notoginseng, Flos Lonicerae 8 parts, it is dried, breaks into coarse powder, with sucrose 8 parts mixing, be dried, then break into fine powder； The clear paste such as above-mentioned fine powder and Herba Taraxaci are mixed and makes soft material, make granule by one-step palletizing ebullated dryer, be distributed into 5g/ Bag, to obtain final product.

3.3 functions cure mainly and usage and dosage

(1) function cures mainly: heat-clearing and toxic substances removing, treating tuberculosis and killing worm, hemostasis and pain-relieving, nourishing YIN and moistening the lung, nourishing kidney pathogenic fire reducing, supplementing QI and nourishing YIN, and YIN nourishing is mended Sun, vital base and primordial QI consolidating.For treating tuberculosis.

(2) usage and dosage: use brewed in hot water 5min, oral, each serving 5g (bag), take day 3 times, take more than 10 weeks continuously.

3.4 drug efficacy assays

(1) Flos Lonicerae: this product is caprifoliaceae plant Radix Ophiopogonis Lonicera japonica Thunb, Flos Lonicerae L.ypogluca Miq., The flower that Flos Lonicerae L.confusa DC or the dry flower of hair style Radix Ophiopogonis L.dasystyla Rehd. or band just open.

Nature and flavor with return footpath: sweet, cold；Return lung, the heart, stomach footpath.

Function with cure mainly: heat-clearing and toxic substances removing, wind-heat dissipating.For carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, Damp disease is generated heat.

Chemical composition: luteolin (luteolin), inositol (inositol), chlorogenic acid (chlorogenic acid), different The volatilizations such as chlorogenic acid phenol (isochlorogenic acid), linalool, isodigeranyl flower alcohol, benzyl alcohol, phenethanol, eugenol Oil, flavonoid, triterpenoid compound, Fe, Mn, Cu, Zn, Ti, Sr, Mo, Ba, Ni, Cr, Pb, V, Co, Li, The trace element such as Ga.

Pharmacological action: antibacterial action, antiinflammatory refrigeration function, hepatoprotective effect, excited uterus effect (chlorogenic acid), central excitation are made With, excited the intestines and stomach promotees gastric juice and bile secretion effect.

Clinical effect: treatment upper respiratory tract infection, bacterial infection, hyperpyrexia, tonsillitis, chronic pharyngitis, parotitis, Hyperlipemia, osteomyelitis, pneumosilicosis and pulmonary infection, appendicitis, mastitis, nephritis, hepatitis, enteritis, infantile pneumonia, wind Rash, urticaria, dermatosis etc..

Documents and materials: She Jing etc. compile " Chinese medicine modern study and application " ISBN7-5077-1318-0 Xueyuan Press 1998 1 Month first edition page 2955.

(2) Herba Taraxaci: this product is feverfew Herba Taraxaci Taraxacum mongolucum Hand.-Mazz, alkali ground Herba Taraxaci Tana Sinicum Kitag or the dry herb of congener.Ministry of Health of China on February 28th, 2002 is " about further specification The notice of healthy food material management ", it is classified as " being food and the article list of medicine ".

Nature and flavor with return footpath: bitter, sweet, cold, return liver, stomach footpath.

Function with cure mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.For furuncle toxic swelling, acute mastitis, scrofula is sick, conjunctival congestion, pharynx Bitterly, lung abscess, acute appendicitis, damp and hot jaundice, the puckery pain of pyretic stranguria.

Chemical composition: taraxasterol (Taraxasterol), β-Amyrin (β-amyrin), stigmasterol (stigmasterol), cupreol (β-sitosterol), phylloxanthin (Cutein), violaxanthin (violaxanthin), Phylloquinone (plastoquinone), the cattle glycol Han mountain gold (arnidiol), the composition such as phylloxanthin and flavoxanthin in spending；Every hectogram Sugary 11g in Herba Taraxaci, protein 3.6g, fat 1.7g, calcium 115mg, phosphorus 115mg, ferrum 12.4mg, vitamin C 47mg, Carotene 7.08mg, riboflavin 0.39mg, thiamine 0.04mg, and containing folic acid, vitamin B etc..

Pharmacological action: resisting pathogenic microbes effect, to staphylococcus aureus, Hemolytic streptococcus and card ground diplococcus, pneumonia Diplococcus, meningococcus, diphtheria corynebacterium, dysentery bacterium and bacillus pyocyaneus etc. have stronger inhibitory action.Promote liver function of gallbladder promoting to resist Ulcer function, etc..

Clinical practice: the high heat for the treatment of, treats upper respiratory tract infection, and acute pharyngolaryngitis, parotitis, chronic gastritis and digestive tract are burst Infections, acute hepatitis, hyperlipemia, renal failure, urinary system infection, erysipelas, pelvic inflammatory disease, folliculitis, otitis media, Mastitis etc.；It is that master adds the clinical treatment stranguria such as Flos Lonicerae, Radix Glycyrrhizae (scorching hot, the stomachache of urgent micturition, frequent micturition, yellowish urine etc.) with Herba Taraxaci Aggregate efficiency 97%.

Documents and materials: She Jing etc. compile " Chinese medicine modern study and application " ISBN7-5077-1318-0 Xueyuan Press 1998 1 Month first edition, page 4453.

(3) Radix Notoginseng (Radix Notoginseng): this product is the dry root of araliad Radix Notoginseng panax notoginseng (Burk) F.H.Chen.

Nature and flavor with return footpath: hardship sweet, micro-, temperature.Return liver, stomach footpath.

Function with cure mainly: eliminating stasis to stop pain, subduing swelling and relieving pain.For spitting blood, epistaxis, have blood in stool, spit blood, metrorrhagia, traumatic hemorrhage, Chest and abdomen twinge, tumbling and swelling.

Chemical composition: volatile oil component has γ-Cananga odorata oil alkene (γ-muurolene), He oxalene (cyperene), α-elemene (α -elemene), γ-cadinene (Cadinene), α-Gu cloud alkene (α-gurijnene), α-guaiene (α-guainene), α-copaene (α-Copaene), α-himachalene (α-cedrene) etc.；Saponin and ruscogenin: ginsenoside (ginsenoside), gypenoside (gypenoside), dencichine (dencichine), cupreol (β-Sitosterol), Daucosterol (daucosterol), Quercetin (quercetin), stigmasterol, sucrose, xylose, Cortex querci dentatae glucose and sodium, potassium, The multiple elements such as ferrum, manganese, zinc.

Pharmacological action: the protective effect to heart, expands blood vessel hypotensive activity, to blood and the anastalsis of hemopoietic system, Blood coagulation (DIC) acts on, effect for reducing blood fat, dissipating blood stasis blood effect, bone marrow granulocyte facilitation, antiinflammatory action.To brain and myelopathy Become Conservative restoration effect, analgesic activity, Endocrine and metabolic system hypoglycemic activity, growth promoting function, promote androgenic and make With, strengthen immunization, delaying senility function, to oxygen radical removing effect, to liver protection, antiulcer action, Strong effect, antivirus action, anti-dermatophyte etc.

Clinical practice: treatment hemorrhage, craniocerebral trauma and internal hemorrhage, cerebrovascular, cerebral infarction, myocarditis tachycardia, breast Coerce into wound, sprained ankle, the retinal vein occlusion, coronary heart disease, chronic atrial fibrillation, pulmonary heart disease, hyperlipemia, hypertension, Leukemia, digestive tract ulcer, gastropathy, hepatopathy, migraine, prostate hyperplasia is various hemorrhage etc..

Documents and materials: 1. Chinese Pharmacopoeia version in 2010 first page 11.2. Xie Zongwan chief editor " whole nation Chinese herbal medicine compilation " ISBN7-117-02380-5/8.285, People's Health Publisher's in October, 1996 second edition, page 25.3. the new medical science in Jiangsu " Chinese medicine voluminous dictionary " ISBN7-5323-0842-1/R-230 compiles in institute, Science and Technology of Shanghai publishing house May in 1986 the 1st edition, and 2003 The 15th printing in May in year, page 54.4. She Jing etc. compile " Chinese medicine modern study and application " ISBN7-5077-1318-0 learning centre Publishing house's in January, 1998 first edition, page 195.

(4) Radix Platycodonis: this product is the dry root of campanulaceae planting platycodon radix Playcodon grandifforum (Jacq) A.DC.

Nature and flavor with return through: bitter, pungent, flat.Return lung footpath.

Function with cure mainly: lung qi dispersing, sore-throat relieving, eliminate the phlegm, evacuation of pus.For cough ant phlegm, pharyngalgia hoarseness, lung abscess vomiting pus, skin infection pus Become not burst.

Chemical composition: platycodigenin (platycodigenin), Polygalacic acid (polygalacic acid), platycogenic acid (platycogcnio acid A, B, C), chondrillasterol (α-spinasterol), stigmasterol (A-stigmasterol), white Birch ester alcohol (Betulin), cupreol, 24 kinds of trace element such as 18 kinds of aminoacid, selenium, zinc, ferrum such as threonine.

Pharmacological action: eliminate the phlegm, antitussive effect, antipyretic effect, antiinflammatory action, antiulcer action, expand blood vessel function, Suppression nervus centralis effect, blood sugar lowering and effect for reducing blood fat, antihistaminic cholinolytic effect, diuresis, epidermophyton suppresses Effect, antitumor action etc..

Clinical practice: treatment chronic tracheitis, bronchitis, chronic pharyngitis, treatment chloasma etc..

Documents and materials: 1. Chinese Pharmacopoeia version in 2010 first page 259.2. She Jing etc. compile " Chinese medicine modern study and application " ISBN7-5077-1318-0 Xueyuan Press in January, 1998 first edition page 3627.3. Xie Zongwan chief editor " whole nation Chinese herbal medicine remittance Compile " ISBN7-117-02380-5/8.285, People's Health Publisher's in October, 1996 second edition, page 684.4. Jiangsu is new Medical college compiles " Chinese medicine voluminous dictionary " ISBN7-5323-0842-1/R-230, Science and Technology of Shanghai publishing house May in 1986 the 1st edition, The 15th printing May in 2003, page 1775.

(5) Pseudobulbus Bletillae (Rhizoma Bletillae): this product is the dry tuber of orchid Pseudobulbus Bletillae (Rhizoma Bletillae) Bletilla striata (Thunb.) Reichb.F..China Ministry of Public Health is classified as the article that can be used for health food.Pseudobulbus Bletillae (Rhizoma Bletillae) processing method: picked up by Pseudobulbus Bletillae (Rhizoma Bletillae) and pick, cleans, cooks, thinly slice, Dry, break into fine powder.

Nature and flavor with return footpath: bitter, sweet, puckery, be slightly cold.Return lung, liver, stomach footpath.

Function with cure mainly: astringing to arrest bleeding, detumescence and promoting granulation.Spit blood for hemoptysis, traumatic hemorrhage, sore swollen toxin, wrinkled skin, Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.

Chemical composition: contain dihydro phenanthrene pyrans in Pseudobulbus Bletillae (Rhizoma Bletillae), dibenzyl dihydro is luxuriant and rich with fragrance and joins sugar etc.；Starch, glucose, mannan Deng saccharide；Anthraquinone derivative and antiulcer composition Bs-1-4, P-hydroxybenzoic acid (P-Hydroxybenzoic acid), to hydroxyl Benzaldehyde, cinnamic acid (Cinnamic acid), volatile oil etc..

Pharmacological action: antiulcer action, anastalsis, antibacterial action, antitumor action, rise blood pressure effect etc..

Clinical practice: treatment gastritis and digestive tract ulcer, upper gastrointestinal hemorrhage, colitis, acute pancreatitis, chyluria, kidney Tumor, burn and scald, hemoptysis, epistaxis, intestinal hemorrhage of typhoid fever, tuberculosis, treatment traumatic surface or diabetic skin ulcer, ulcer Infect etc..

Documents and materials: 1. Chinese Pharmacopoeia version in 2010 first page 95.2. She Jing etc. compile " Chinese medicine modern study and application " ISBN7-5077-1318-0 Xueyuan Press in January, 1998 first edition page 1952.3. Xie Zongwan chief editor " whole nation Chinese herbal medicine remittance Compile " ISBN7-117-02380-5/8.285, People's Health Publisher's in October, 1996 second edition, page 258.4. Jiangsu is new Medical college compiles " Chinese medicine voluminous dictionary " ISBN7-5323-0842-1/R-230, Science and Technology of Shanghai publishing house May in 1986 the 1st edition, The 15th printing May in 2003, page 667.

(6) Radix Ranunculi Ternati: this product is the dried root of MAOGENG section plant ranunculus ternatus Ranunculus ternatus Thunb..

Nature and flavor with return footpath: sweet, acrid, warm.Return liver, lung footpath.

Function with cure mainly: mass dissipating and swelling eliminating.For scrofula, tuberculous lymphadenitis is not burst.

Chemical composition: ranunculus ternatus lactone (Ternateolide), former white father-in-law element (protoanemonin), arachic acid (Eiosanoic Acid), stigmasterol (Stigmasterol), cupreol (β-sitosterol), myristic acid octadecyl ester, glucose, Ah anti-'s white sugar, galactose, vegetable oil, alkali etc..

Clinical practice: control lymphoid tuberculosis, pulmonary tuberculosis, bone tuberculosis, cyclomastopathy, skin infection, pharyngolaryngitis etc..

Documents and materials: 1. Chinese Pharmacopoeia version in 2010 first page 300.2. She Jing etc. compile " Chinese medicine modern study and application " ISBN7-5077-1318-0 Xueyuan Press in January, 1998 first edition page 4184.3. Xie Zongwan chief editor " whole nation Chinese herbal medicine remittance Compile " ISBN7-117-02380-5/8.285, People's Health Publisher's in October, 1996 second edition, page 817.4. Jiangsu is new Medical college compiles " Chinese medicine voluminous dictionary " ISBN7-5323-0842-1/R-230, Science and Technology of Shanghai publishing house May in 1986 the 1st edition, The 15th printing May in 2003, page 2206.

(7) Radix Pseudostellariae: this product is pinkwort Radix Ginseng Pseudostellaria heterophylla (Miqe.) Pax et pax The dry root of et Hoffm..It is again Radix Ginseng.

Nature and flavor with return footpath: hardship sweet, micro-, flat.Return spleen, lung footpath.

Function with cure mainly: replenishing QI to invigorate the spleen, promoting the production of body fluid for nourishing the lung, tired for insufficiency of the spleen body.Inappetence, weak after being ill, deficiency of both vital energy and Yin, Spontaneous perspiration is thirsty, dryness of the lung dry cough.

Chemical composition: containing carbohydrate content, aminoacid and the trace element such as Saponin, starch, fructose, maltose, sucrose, Petiolus Trachycarpi Acid, linoleic acid, glycerol-1-list linoleate (glycerol-1-menoliolate), behenic acid, cupreol (β-sitost), Glyceride, daucosterol, Radix Pseudostellariae ring phthalein (heter ophyllin A, B).

Clinical practice: cough in lung road, acute, chronic hepatitis, neurasthenia, cardiopalmus is thirsty, inappetence, point stomach invigorating, nourishes, Tonifying QI to produce body fluid etc..

Documents and materials: 1. Chinese Pharmacopoeia version in 2010 first page 62.2. She Jing etc. compile " Chinese medicine modern study and application " ISBN7-5077-1318-0 Xueyuan Press in January, 1998 first edition page 955.3. Xie Zongwan chief editor " whole nation Chinese herbal medicine remittance Compile " ISBN7-117-02380-5/8.285, People's Health Publisher's in October, 1996 second edition, page 617.4. Jiangsu is new Medical college compiles " Chinese medicine voluminous dictionary " ISBN7-5323-0842-1/R-230, Science and Technology of Shanghai publishing house May in 1986 the 1st edition, The 15th printing May in 2003, page 374.

(8) Radix Codonopsis: this product is Ku Geng section plant Radix Codonopsis Codonopsis pilosula (F-ranch) Nannf, element flower Radix Codonopsis Codonopsis pilesula Nannf.Var.modesta (Nannf.) L.T.shen or radix codonpsis tangshen Codonopsis The dry root of tangshen Oliv..

Nature and flavor with return footpath: sweet, flat.Return spleen, lung footpath.

Function with cure mainly: invigorating the spleen and replenishing QI, strengthening spleen and tonifying lung.For deficiency of the spleen and lung, breathe hard heart season, anorexia and loose stool, dyspnea due to deficiency cough, Interior-heat is quenched one's thirst.

Chemical composition: chondrillasterol (α-spinasterol), stigmastenol (stigmastenol), inulin (inulin), really Sugar (fructose), tangshenoside (tangshenoside), choline (choline), caproic acid (caproic acid), inorganic elements (ferrum, Zinc, copper, manganese, cobalt, chromium, molybdenum, selenium etc.) and 18 kinds of aminoacid such as threonine, aspartic acid, isoleucine, alanine, Etc..

Pharmacological action: antiulcer action, hypermnesis effect, anti-stress effect, immunization, anti-arrhythmia effect, fall Blood pressure effect, the viscous effect of anticoagulation, blood glucose increasing effect etc..

Clinical practice: prevent and treat coronary heart disease, treats hyperlipemia, treats hypopiesi, treats leukopenia, treats kidney Anemia, treatment chronic bronchitis and esophageal precancerous lesion, cause hematopoietic disorder and immunologic function in chemotherapy, treat functional Metrorrhagia, frequent fetal movement, neurosis etc..

Documents and materials: She Jing etc. compile " Chinese medicine modern study and application " ISBN7-5077-1318-0 Xueyuan Press 1998 1 Month first edition page 3718.

3.5 guardian technique

(1) prescription composition

Herba Taraxaci heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome, tubercule bacillus etc. there is is inhibitory action；Radix Ranunculi Ternati mass dissipating and swelling eliminating； This two taste is that the main force for the treatment of tuberculosis and killing worm works as monarch drug.Radix Notoginseng eliminating stagnation is stopped blooding, subduing swelling and relieving pain；Pseudobulbus Bletillae (Rhizoma Bletillae) astringing to arrest bleeding, detumescence and promoting granulation； This two tastes mass dissipating and swelling eliminating, analgesic therapy of stopping blooding, convergence granulation promoting is worked as ministerial drug.Flos Lonicerae heat-clearing and toxic substances removing, wind-heat dissipating；Radix Platycodonis lung qi dispersing, Sore-throat relieving, eliminates the phlegm, evacuation of pus；This two taste is controlled the table of pulmonary tuberculosis is auxiliary, when for adjuvant drug.Radix Pseudostellariae replenishing QI to invigorate the spleen, promoting the production of body fluid for nourishing the lung；Radix Codonopsis Invigorating the spleen and replenishing QI, strengthening spleen and tonifying lung, there is the effect of " tonification training is first ", make medicine for it.

Above-mentioned 8 kinds of prescriptions are set up: " heat-clearing and toxic substances removing, treating tuberculosis and killing worm, hemostasis and pain-relieving, nourishing YIN and moistening the lung, nourishing kidney pathogenic fire reducing, QI invigorating is supported The moon, nourishing YIN and invigorating YANG, vital base and primordial QI consolidating " effect, attack strategy prescription complete to treatment by Chinese herbs lungy.

(2) preparation utilizes with effective ingredient

Pseudobulbus Bletillae (Rhizoma Bletillae) composition colloid is enriched, and it is exactly so that alcohol mentions that water carries its medicinal ingredient, and hard being difficult to of dried matter is pulverized, thus adopts Thinly slice after cooking, easily broken after drying；Radix Pseudostellariae, Radix Ranunculi Ternati are medicinal tuber, and Radix Notoginseng is the hardest, use First being broken into fritter and break into coarse powder, Chinese medicine honeysuckle is fine, so with Radix Notoginseng coarse powder, Radix Pseudostellariae, Radix Ranunculi Ternati, Flos Lonicerae with viscous Property weight Pseudobulbus Bletillae (Rhizoma Bletillae) thin slice mixing beat powder, make viscosity and dry property powder adsorb comprehensively mutually, be beneficial to be ground into fine powder, reach preferably to absorb effect Really, accomplish that medical material full dose effectively utilizes.

Cupreol in Herba Taraxaci is insoluble in water, dissolubility only 4% in chlorogenic acid water；Polysaccharide in Radix Platycodonis, steroidal, fat Fat oil etc. is insoluble in water；In Radix Codonopsis, stigmasterol, oleanolic acid etc. are insoluble in water；So Herba Taraxaci, Radix Platycodonis, Radix Codonopsis 3 taste use The method that alcohol extraction water again carries effective ingredient, can extract medicinal ingredient more completely.Because Pseudobulbus Bletillae (Rhizoma Bletillae) has stronger toughness, add 8% sucrose Powder as supplementing binding agent, second changes the bitterness such as Herba Taraxaci first for sweeting agent, and three tuberculosis need additional heat, make prescription more Add effectively.

3.6 beneficial effects of the present invention

(1) chronic infection of pulmonary tuberculosis system is sick, and it is main for need to effecting a permanent cure, and uses the phthisical Chinese patent medicine for the treatment of the most clinically because of by its centering Medicine modern study is not enough and has the Chinese patent medicine of good therapeutic effect actually rare, invention increases patient's selection to Chinese patent medicine.

(2) clinical effectiveness (preliminary identification): the present invention is through being diagnosed as the tool traditional Chinese medical science it " pulmonary tuberculosis " symptom for 7 examples, and the age is at 45-75 In year, all cases all tie up to take after countries such as " rifampicin " provides free 1 course for the treatment of of chemical drugs takes granule of the present invention simultaneously Continuous 10 weeks of agent, check symptom substantially completely disappears, and illustrates that this prescription has better effects to after treatment lungy.

4 detailed description of the invention

4.1 prescription compositions: Herba Taraxaci 20 parts, Radix Platycodonis 8 parts, Radix Codonopsis 10 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 parts, Radix Pseudostellariae 8 parts, Radix Ranunculi Ternati 20 parts, 8 parts of Radix Notoginseng, Flos Lonicerae 8 parts, sucrose (binding agent, sweeting agent) 8 parts.

Note: within every kind of taken amount error when being embodied as should be the 95%-105% of labelled amount.

4.2 functions cure mainly: heat-clearing and toxic substances removing, treating tuberculosis and killing worm, hemostasis and pain-relieving, nourishing YIN and moistening the lung, nourishing kidney pathogenic fire reducing, supplementing QI and nourishing YIN, and YIN nourishing is mended Sun, vital base and primordial QI consolidating.For treating tuberculosis.

4.3 usage and dosages: use brewed in hot water 5min, oral, each serving 5g (bag), take 3 bags day, take more than 10 weeks continuously.

4.4 raw material sources and quality standard

(1) Flos Lonicerae: Chinese Pharmacopoeia version in 2010 first page 205.

(2) Herba Taraxaci: Chinese Pharmacopoeia version in 2010 first page 331.

(3) Radix Platycodonis: Chinese Pharmacopoeia version in 2010 first page 259.

(4) Pseudobulbus Bletillae (Rhizoma Bletillae): Chinese Pharmacopoeia version in 2010 first page 95.

(5) Radix Pseudostellariae: Chinese Pharmacopoeia version in 2010 first page 62.

(6) Radix Ranunculi Ternati: Chinese Pharmacopoeia version in 2010 first page 300.

(7) Radix Notoginseng: Chinese Pharmacopoeia version in 2010 first page 11.

(8) Radix Codonopsis: Chinese Pharmacopoeia version in 2010 first page 261.

(9) sucrose: Chinese Pharmacopoeia version in 2010 second page 1251.

4.5 technological procedure

Produce under the conditions of GMP Factory Building.

(1) Herba Taraxaci, Radix Platycodonis, Radix Codonopsis are picked up and are picked, clean, drain water stain, put into alcohol extraction water intaking and carry in linkage integration extraction element, Add 10 times amount 70% ethanols and soak 8h；

(2) reflux, extract, 120min, leaching alcohol extract, reclaims ethanol；Extract pus is reduced to clear paste and makes into proportion 1: 1.05；

(3) Pseudobulbus Bletillae (Rhizoma Bletillae) is cleaned, cook, thinly slice, be dried, beat after Radix Pseudostellariae, Flos Lonicerae, Radix Ranunculi Ternati, Radix Notoginseng combination drying Become coarse powder, mix with sucrose, dry, then break into fine powder；

(4) above-mentioned clear paste and fine medicinal material powder are mixed make soft material, make granule by one-step palletizing ebullated dryer；

(5) subpackage: by above-mentioned granule subpackage, every 5g/ bag, seal；

(6) packaging: mounted box, vanning, play band, warehouse-in, to obtain final product.

4.6 are embodied as example

Take Herba Taraxaci 20kg, Radix Platycodonis 8kg, Radix Codonopsis 10kg, Pseudobulbus Bletillae (Rhizoma Bletillae) 10kg, Radix Pseudostellariae 8kg, Radix Ranunculi Ternati 20kg, Radix Notoginseng 8kg, Flos Lonicerae 8kg, sucrose 8kg, implement according under declaration material description of the present invention " 4.5 technological procedure " item, to obtain final product.

Claims (1)

1. treat Chinese medicine granules lungy for one kind, it is characterised in that: take Herba Taraxaci 20 parts, Radix Platycodonis 8 parts, Radix Codonopsis 10 parts, With 70% alcohol reflux 120min, leaching medicinal liquid, reclaiming ethanol, extracting solution is condensed into clear paste to proportion 1: 1.05；Will be white And 10 parts cook, thinly slice, with Radix Pseudostellariae 8 parts, Radix Ranunculi Ternati 20 parts, 8 parts of Radix Notoginseng, Flos Lonicerae 8 parts, be dried, beat Become coarse powder, with sucrose 8 parts mixing, be dried, then break into fine powder；The clear paste such as above-mentioned fine powder and Herba Taraxaci are mixed and make soft material, Make granule by one-step palletizing ebullated dryer, be distributed into 5g/ bag, to obtain final product.For treating tuberculosis, each 1 bag, use Brewed in hot water 5min, oral, each serving 5g (bag), take day 3 times, take more than 10 weeks continuously.