CN1269504C - Medicine for treating rheumatic and rheumatoid arthritis - Google Patents

Abstract

The present invention relates to a medicine for treating rheumatism and rheumatoid arthritis, which belongs to the field of traditional Chinese medicines. The medicine is prepared from thirteen natural Chinese herbal medicines of white peony root, eucommia bark, peucedanum root, lotus leaf, olibanum, ledebouriella root, safflower, costustoot, liquoric root, ladybell root, barbary wolfberry fruit, twotooth achyranthes root, indian bread with hostwood, etc. The prescription of the medicine of the present invention is unique, through the synergism and the supplementation of all medicinal components for body consolidation and strengthening, the functions of activating blood circulation to dissipate blood stasis, relaxing muscles and tendons and dredging channels are achieved. The sweat pores from head to foot of a patient can be opened quickly, and wind, coldness and noxious dampness are discharged from bones and joints, and wind, coldness and noxious dampness in the five viscera are discharged from bodies through excrement and urine; thus, the channels and collaterals from head to foot are opened, and rheumatism and rheumatoid arthritis are radically cured. At the same time, the medicine has good curative effect on raynauds disease, cervical spondylosis, periarthritis of shoulder, ankylosing spondylitis, etc. caused by cold and dampness. The present invention has the characteristics of simple preparation technology, low cost, significant and reliable curative effects, no relapse, no toxic and side effect, etc.; the total effective rate reaches 98.5%.

Description

A kind of medicine for the treatment of rheumatism, rheumatoid arthritis

Technical field

The present invention relates to a kind of medicine for the treatment of rheumatism, rheumatoid arthritis, belong to the field of Chinese medicines.

Background technology

Rheumatism, rheumatoid arthritis are universally acknowledged difficult miscellaneous diseases, persistent ailments, though there is multiple medicine to occur, exist deficiencies such as prescription is numerous and diverse, cost is high, drug toxicity is more, the undesirable easy recurrence of curative effect in various degree.

Summary of the invention

The purpose of this invention is to provide a kind of prescription uniqueness, treatment rheumatism evident in efficacy, the medicine of rheumatoid arthritis.

13 flavor natural Chinese medicinal herb such as choice of drug Radix Paeoniae Alba of the present invention, the Cortex Eucommiae, Radix Peucedani, Folium Nelumbinis, Olibanum, Radix Saposhnikoviae, Flos Carthami, the Radix Aucklandiae, Radix Glycyrrhizae, Radix Adenophorae, Fructus Lycii, Radix Achyranthis Bidentatae, Poria cum Radix Pini can effectively be treated diseases such as rheumatism, rheumatoid arthritis through the science compatibility thereby make each efficacy of drugs produce synergism.

The root of Radix Paeoniae Alba ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall..

The dry bark of Cortex Eucommiae Eucommiaceae plant Cortex Eucommiae Eucommia ulmoides Oliv..

The dry root of Radix Peucedani samphire Peucedanum praeruptorum DUNN Peucedanum praeruptorum Dunn or RADIX PEUCEDANI Peucedanum decursivum (Miq.) Maxim..

The leaf of Folium Nelumbinis nymphaeaceae plant lotus Nelumbo nucifera Gaertn..

The gum resin of Olibanum olive subject plant Boswellia carterii Birdw Boswellia carterii Birdw..

The root of Radix Saposhnikoviae umbelliferae Saposhnikovia divaricata Saposhni kovia divaricata (Turcz.) Schischk.

The dried floral of Flos Carthami feverfew Flos Carthami Carthamus tinctorius L..

The dry root of Radix Aucklandiae feverfew Saussurea lappa Clarke Saussurea lappa Clarke, vladimiria denticulata Ling Vladimiriadenticulata Ling, Radix Vladimiriae Vladimiria souliei (Franch.) Ling etc.

Dry root and the root stock of Radix Glycyrrhizae glycyrrhizic legume Glycyrrhiza uralensis Fisch..

The root of Radix Adenophorae campanulaceae plant adenophora tetraphylla Adenophora tetraphylla (Thunb.) Fisch., Folium Pruni Radix Adenophorae (Radix Glehniae) Adenophora axilliflora Borb. or other several congeners.

The dry mature fruit of Fructus Lycii matrimony vine of solanaceae plant Lycium chinense Mill. or lycium barbarum Lgcium barbarumL..

The dry root of Radix Achyranthis Bidentatae amaranthaceous plant Radix Achyranthis Bidentatae Achyranthes bidentata Bl..

The natural white portion of entertaining Radix Pini massonianae (Lignum Poria) in the middle of Poria cum Radix Pini's Polyporaceae plant Poria Poria cocos (Schw.) Wolf sclerotium.

The objective of the invention is to be achieved through the following technical solutions.

A kind of medicine for the treatment of rheumatism, rheumatoid arthritis, make by following bulk drugs:

Radix Paeoniae Alba 5-15 part, Cortex Eucommiae 5-15 part, Radix Peucedani 5-15 part, Folium Nelumbinis 5-15 part, Olibanum 5-15 part, Radix Saposhnikoviae 10-20 part, Flos Carthami 5-15 part, Radix Aucklandiae 5-15 part, Radix Glycyrrhizae 5-15 part, Radix Adenophorae 5-15 part, Fructus Lycii 10-20 part, Radix Achyranthis Bidentatae 10-20 part, Poria cum Radix Pini 10-20 part.

Each amounts of components all has better curative effect in the following weight parts scope:

Radix Paeoniae Alba 7-13 part, Cortex Eucommiae 7-13 part, Radix Peucedani 7-13 part, Folium Nelumbinis 7-13 part, Olibanum 7-13 part, Radix Saposhnikoviae 13-17 part, Flos Carthami 7-13 part, Radix Aucklandiae 7-13 part, Radix Glycyrrhizae 7-13 part, Radix Adenophorae 7-13 part, Fructus Lycii 13-17 part, Radix Achyranthis Bidentatae 13-17 part, Poria cum Radix Pini 13-17 part.

Be preferably:

10 parts of Radix Paeoniae Alba, 10 parts of the Cortexs Eucommiae, 10 parts of Radix Peucedanis, 10 parts on Folium Nelumbinis, 10 parts of Olibanums, 15 parts of Radix Saposhnikoviaes, 10 parts on Flos Carthami, 10 parts of the Radix Aucklandiae, 10 parts in Radix Glycyrrhizae, 10 parts of Radix Adenophoraes, 15 parts of Fructus Lycii, 15 parts of Radix Achyranthis Bidentataes, 15 parts of Poria cum Radix Pinis.

Required various conventional adjuvant was prepared into any conventional oral preparations when the conventional method that medicine of the present invention can adopt Chinese medicine preparation added the preparation different dosage form with the active component of medicine of the present invention.For example these crude drug pulverize mix homogeneously can be made powder, pill or made capsule, tablet; Can or extract active component and make oral liquid these crude drug decoctings, condensed water decocting liquid, also can make powder, capsule etc. pulverizing behind the extracting solution concentrate drying.But these can not be used to limit protection scope of the present invention.

Medicament composing prescription uniqueness of the present invention, each component drug synergism complements each other, and consolidates and keeps fit, and reaches blood circulation promoting and blood stasis dispelling, channels sootheing and network vessel quickening, can very fast patient's whole body fine hair hole be opened, and wind, cold, noxious dampness are discharged from skeleton, joint; Wind in the five internal organs, cold, noxious dampness are got rid of from convenient to both, fundamentally cure rheumatism, rheumatoid arthritis thereby get through whole body meridian, thoroughly change other drug and treat this disease and can not go root and the easy deficiency that recurs.Disease all had better curative effect due to medicine of the present invention was wet by wind and cold to Raynaud disease, cervical spondylosis, scapulohumeral periarthritis, ankylosing spondylitis etc.Have characteristics such as preparation technology is simple, cost is low, therapeutic effect is significantly reliable and efficacy consolidation does not recur, without any side effects, total effective rate reaches 98.5%.

The specific embodiment

Below by embodiment the present invention is further described.

Embodiment 1-5: the preparation of the oral liquid of medicine of the present invention

The consumption of each crude drug sees Table 1 among each embodiment.

Table 1

Embodiment number	1	2	3	4	5
						Radix Paeoniae Alba (kg)	5	8	10	13	15
The Cortex Eucommiae (kg)	5	7	10	12	15
						Radix Peucedani (kg)	5	9	10	11	15
Folium Nelumbinis (kg)	5	7	10	14	15
						Olibanum (kg)	5	6	10	13	15
Radix Saposhnikoviae (kg)	10	13	15	18	20
						Flos Carthami (kg)	5	6	10	13	15
The Radix Aucklandiae (kg)	5	7	10	12	15
						Radix Glycyrrhizae (kg)	5	9	10	11	15
Radix Adenophorae (kg)	5	9	10	12	15
						Fructus Lycii (kg)	10	14	15	17	20
Radix Achyranthis Bidentatae (kg)	10	9	15	18	20
						Poria cum Radix Pini (kg)	10	9	15	19	20

Preparation method: after described materials of weight proportions medicine screened purified treatment respectively by different pharmacological properties, extract the oral liquid that makes medicine of the present invention behind its effective ingredient according to a conventional method.

Embodiment 6: the clinical observation of Drug therapy rheumatism of the present invention, rheumatoid arthritis

1, physical data

The inventor accepted outpatient service rheumatism, patient with rheumatoid arthritis totally 198 examples in 1999 for medical treatment, wherein: male 87 examples, women 111 examples, 51.21 years old mean age.1-3 patient's 43 examples wherein, 3-5 patient's 109 examples, patient's 46 examples more than 5 years.All cases are by being divided into treatment group and matched group at 2: 1, and two groups all have comparability at age, sex, the course of disease, clinical setting.

2, Therapeutic Method

The oral liquid of treatment group oral embodiment 3 gained every day medicine of the present invention three times, each one bag (170g/ bag), 30 minutes after meal heating garment usefulness, 7 days is a course of treatment, 35 days treatment times.If any nauseating, symptoms of emesis, can be in the preceding 30 minutes oral vitamin B6 4-6 sheets of taking medicine; Vomit as also having, but decrement is taken several times.

Period in a medicine should notice that wind sheltering is warming, can not arrive outdoorly, can not see that wind catches a cold, and 8-10 days can arrive outdoor after the drug withdrawal.Take medicine the initial stage, most of patient pain and swelling can occur and add reconstructed image, can take the analgesic that does not contain hormone on a small quantity.That some patient occurs at the initial stage of taking medicine is just rare, anorexia, phenomenon such as feel cold, the later stage whole body heating of taking medicine, and it is normal gradually defecate, swollen, expanding alleviates gradually, and finger, the disappearance of toe distending pain easily get final product drug withdrawal from head to foot.

Matched group is taken existing Chinese patent medicine: TONGREN DAHUOLUO WAN, Tongrentang Pharmaceutical Factory, Beijing TongrenTang Co., Ltd, the accurate word Z11020090 of traditional Chinese medicines, warm yellow wine or warm water delivery service, a 1-2 ball, 2 times on the one, 3.6g/ ball; FENGSHIDING JIAONANG, the chief Pharmaceutical in Jilin Co., Ltd, the accurate word Z22023508 of traditional Chinese medicines, oral one time 2,2 times on the one, the 0.3g/ grain; FENGTONGNING PIAN, Guokang Medicine Industry Co Ltd, Sichuan, the accurate word Z19993147 of traditional Chinese medicines, oral one time 3,3 times on the one, warm water delivery service, 0.33g/ sheet.

3, efficacy assessment standard

Cure fully: symptoms such as joint, finger, swollen feet all disappear, and whole body is painless, and is light from head to foot, freedom of movement, and 5 years efficacy consolidations are followed up a case by regular visits in tracking is not had recurrence;

The basic healing: pain disappears, and finger, foot, joint are stretched and bent not seriously, little the swelling sense is arranged, follows the tracks of and follow up a case by regular visits to 3 years efficacy consolidations and do not have recurrence;

Alleviate: more than the stadium 5-6, treatment back symptom makes moderate progress;

Invalid: symptom does not have lasting deterioration that take a turn for the better.

4, therapeutic outcome

Clinical efficacy relatively sees Table 2 between (1) two group.

Table 2

	n	Cure fully		The basic healing		Alleviate		Invalid
										Case load	％	Case load	％	Case load	％	Case load	％
		The treatment group	132	107	81.1	15	11.4	8	6.0									2	1.5
Matched group	66									5	7.6	13	19.7	26	39.4	22	33.3

Test statistics shows: the treatment group is cured fully and is accounted for 81.1%, and basic the healing accounts for 11.4%, alleviates to account for 6.0%, and total effective rate reaches 98.5%, wherein cures fully, the basic healing account for 92.5%.Matched group total effective rate 66.7%, wherein healing fully, basic healing only account for 27.3%.Curative effect has utmost point significant difference (p＜0.01) between two groups, and treatment group curative effect obviously is better than matched group.

After (2) 5 years effective case is followed the tracks of the relapse rate of following up a case by regular visits between two groups and relatively see Table 3.

Table 3

	n	Recur routine number	Relapse rate %
				The treatment group	130	9	6.9
Matched group	44	43	97.7

Test statistics shows: relapse rate has utmost point significant difference (p＜0.01) between treatment group and the matched group, and treatment group relapse rate is starkly lower than matched group.

Model case

1, Ma Xiujuan, the woman, 35 years old, occur both hands before 4 years and refer to the white cool pain of color, two carpal joint pain, the cool pain of biped toe, * * institute of traditional Chinese medicine makes a definite diagnosis rheumatoid arthritis, and medication is not felt any better.Taking the oral liquid of medicine of the present invention cures 3 courses of treatment fully.

2, the Wenchang forever, the man, 46 years old, occurred before 2 years that both hands refer to and the both shoulders arthralgia, increase the weight of gradually to cause the both hands ankylosis, be diagnosed as rheumatoid arthritis, the fruits of failing to respond to any medical treatment such as clothes Western medicine.Taking the oral liquid of medicine of the present invention cures 3 courses of treatment fully.

3, Ma Guixiang, the woman, 55 years old, in year surplus the arthralgia 20, be diagnosed as rheumatoid arthritis all over the body, take other medicine and do not feel any better.The oral liquid of taking medicine of the present invention removes the left hand middle finger after 6 courses of treatment, and right hand forefinger is sent out outside cold, the hypodynia sometimes, and surplus disease is almost recovered, and cures fully after 1 after treatment course of treatment that continues to take medicine.

4, Li Wenwu, the man, 37 years old, suffer from the rheumatoid arthritis paralysis, disability for many years, obstinate.The oral liquid of taking medicine of the present invention is lived after 5 courses of treatment and be can take care of oneself, and after treatment is cured after 2 courses of treatment substantially.

5, Huang Jingcheng, the man, 7 years old, occurring whole body arthralgias such as both hands refer to, two wrist, two knee joint, two ankles before 2 years did not have distortion, and how tame hospital is diagnosed as rheumatoid arthritis, the medication unsatisfactory curative effect.Taking the oral liquid of medicine of the present invention cures 1 course of treatment fully.

Claims (3)

1, a kind of medicine for the treatment of rheumatism, rheumatoid arthritis is characterized in that being made by following bulk drugs:

Radix Paeoniae Alba 5-15 part, Cortex Eucommiae 5-15 part, Radix Peucedani 5-15 part, Folium Nelumbinis 5-15 part, Olibanum 5-15 part,

Radix Saposhnikoviae 10-20 part, Flos Carthami 5-15 part, Radix Aucklandiae 5-15 part, Radix Glycyrrhizae 5-15 part, Radix Adenophorae 5-15 part,

Fructus Lycii 10-20 part, Radix Achyranthis Bidentatae 10-20 part, Poria cum Radix Pini 10-20 part.

2, the medicine of treatment rheumatism according to claim 1, rheumatoid arthritis is characterized in that being made by following bulk drugs:

Radix Paeoniae Alba 7-13 part, Cortex Eucommiae 7-13 part, Radix Peucedani 7-13 part, Folium Nelumbinis 7-13 part, Olibanum 7-13 part,

Radix Saposhnikoviae 13-17 part, Flos Carthami 7-13 part, Radix Aucklandiae 7-13 part, Radix Glycyrrhizae 7-13 part, Radix Adenophorae 7-13 part,

Fructus Lycii 13-17 part, Radix Achyranthis Bidentatae 13-17 part, Poria cum Radix Pini 13-17 part.

3, the medicine of treatment rheumatism according to claim 1, rheumatoid arthritis is characterized in that being made by following bulk drugs:

10 parts of Radix Paeoniae Alba, 10 parts of the Cortexs Eucommiae, 10 parts of Radix Peucedanis, 10 parts on Folium Nelumbinis, 10 parts of Olibanums,

15 parts of Radix Saposhnikoviaes, 10 parts on Flos Carthami, 10 parts of the Radix Aucklandiae, 10 parts in Radix Glycyrrhizae, 10 parts of Radix Adenophoraes,

15 parts of Fructus Lycii, 15 parts of Radix Achyranthis Bidentataes, 15 parts of Poria cum Radix Pinis.