CN1183297A - Katsutoxin pill for tumor and preparing method thereof - Google Patents
Katsutoxin pill for tumor and preparing method thereof Download PDFInfo
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- CN1183297A CN1183297A CN97120965A CN97120965A CN1183297A CN 1183297 A CN1183297 A CN 1183297A CN 97120965 A CN97120965 A CN 97120965A CN 97120965 A CN97120965 A CN 97120965A CN 1183297 A CN1183297 A CN 1183297A
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- rhizoma
- radix
- carapax trionycis
- clear paste
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Abstract
A pill for curing the tumors of stomach, intestine, esophagus, liver, breast and brain with high total effective rate (95.5%) and cure rate (72%) and no toxic by-effect is prepared from more than 10 Chinese-medicinal materials such as Katsutoxin, barbat skullcap, etc. through breaking and dicocting raw materials other than scorpion tail and turtle shell, water extraction, alcohol precipitation, addition of powdered scorpion tail and turtle shell, and pilling.
Description
The present invention relates to a kind of Chinese medicine for the treatment of tumor and preparation method thereof.
Tumor is a kind of disease of serious harm people ' s health, and it comprises described benign tumor of modern medicine and pernicious tumor, and wherein gastric tumor has the shallow type of table, massive type, ulcer type etc.; Intestinal tumour has lump type, ulcer type stenotic type; Hepatoma has massive type, nodular type, diffuse type; The esophagus tumor has medullary, ulcer type etc.; Mastoncus has mastofibroma etc.; Cerebroma mostly is glioma.Above-mentioned various tumor still lacks effective medicine except that the treatment that operates.
The purpose of this invention is to provide a kind of Chinese medicine for oral administration for the treatment of tumor, it all has stable curative effect to gastric tumor, intestinal tumour, esophagus, tumor hepatoma, mastoncus, cerebroma, treating both the principal and secondary aspects of a disease, and have no side effect.
The present invention also aims to provide a kind of method for preparing Katsutoxin pill for tumor, its extraction ratio is high and can guarantee the stable performance of curative effect of medication preferably.
The objective of the invention is to realize by following pharmaceutical formulation and preparation method:
The prescription of this medicine and proportioning are: scorpion tail 20-30 gram, Herba Portulacae Grandiflorae 80-120 gram, Herba humuli scandentis 80-120 gram, Rhizoma Atractylodis Macrocephalae 60-100 gram, Semen Coicis 60-100 gram, Rhizoma Pinelliae 80-100 gram, Rhizoma Arisaematis 80-100 gram, Rhizoma Corydalis 80-100 gram, Flos Carthami 80-100 gram, Rhizoma Curcumae 80-100 gram, Carapax Trionycis 60-80 gram, Radix Et Rhizoma Rhei 80-100 gram.
Preparation method of the present invention is:
A. get the raw materials ready according to following prescription and proportioning: the prescription of this medicine and proportioning are: scorpion tail 20-30 gram, Herba Portulacae Grandiflorae 80-120 gram, Herba humuli scandentis 80-120 gram, Rhizoma Atractylodis Macrocephalae 60-100 gram, Semen Coicis 60-100 gram, Rhizoma Pinelliae 80-100 gram, Rhizoma Arisaematis 80-100 gram, Rhizoma Corydalis 80-100 gram, Flos Carthami 80-100 gram, Rhizoma Curcumae 80-100 gram, Carapax Trionycis 60-80 gram, Radix Et Rhizoma Rhei 80-100 gram.It is standby that scorpion tail, Carapax Trionycis are ground into fine powder, and it is even that all the other every medicines give as one thinks fit cataclasm back to mix to play the part of, and adds 15 times water again, decocted 2.5 hours;
B. after obtaining filtrate, in compound, add 5 times water again, decocted 1 hour;
C. merging filtrate, concentrated filtrate to relative density is the clear paste of 1.10-1.15, puts cold;
D. in clear paste, slowly add concentration and be 95% ethanol, make to contain the alcohol amount and reach 60%, fully stir, left standstill 24 hours;
E. filter, reclaim ethanol, concentrated medicament is the clear paste of 1.35-1.40 to relative density;
F. be fine powder with grinding after the clear paste drying, add the former powder of scorpion tail, Carapax Trionycis that has prepared again, add water and granulate, drying is made finished product.
Tcm theory is thought: the cause of disease of tumor is the evil poison of exopathogenic factor six climate exopathogens, in invade internal organs, knot in the evil poison, the cloudy loss of gas, endogenous cause of ill is the healthy energy loss, visceral dysfunction, taste are impaired, qi depression to blood stasis, blood-stasis internal-depression, coagulation in bulk.For this situation, prescription of the present invention is the rule of treatment with spleen invigorating for wet, vegetables liver and qi, lowering the adverse-rising QI and eliminating phlegm and stomach and alleviating pain, hard masses softening and resolving, blood circulation promoting and blood stasis dispelling, detoxifcation tubercle.The present invention is with scorpion tail, Herba Portulacae Grandiflorae, rule grass detoxifcation dispersing tumor, Rhizoma Atractylodis Macrocephalae, Semen Coicis spleen invigorating are for wet, Rhizoma Arisaematis, Rhizoma Pinelliae lowering the adverse-rising QI and eliminating phlegm, Radix Bupleuri, Radix Curcumae, Rhizoma Corydalis depressed liver-energy dispersing and QI regulating and stomach and alleviating pain, Flos Carthami, Rhizoma Curcumae blood circulation promoting and blood stasis dispelling, the Carapax Trionycis softening the hard mass looses and to separate, and Radix Et Rhizoma Rhei is cleansed the gastrointestinal dirt, makes that the present invention plays the dispersing tumor removing dampness, reduces phlegm, regulates the flow of vital energy, the effect of pain relieving, blood stasis-eliminating and stagnation-dissipating.By treatment of the present invention, tumor tumor body disappears, and the ruined tissue of health is eliminated, and is converted into vital normal cell, finally reaches the healing purpose.The present invention carries out acute and chronic test through pharmaceutical college of Heilongjiang University of Chinese Medicine, proves the medicine avirulence; Through 18 months stability tests, prove the medicine stable performance.In the attached First Academy of Heilongjiang University of Chinese Medicine, the attached Second Academy, Harbin City second institute of traditional Chinese medicine will have carried out 300 routine clinical observations to the end of the year one nine nine five in 1990.Receive and all meet the traditional Chinese medical science and Western medicine diagnose standard as the experiment case.Gastric tumor 80 examples wherein, intestinal tumour 35 examples, hepatoma 35 examples, esophagus tumor 50 examples, mastoncus 80 examples, cerebroma 20 examples.All disease is all made a definite diagnosis with symptom, sign, chemical examination, X line or CT examination mode.Through clinical statistics, total effective rate of the present invention is 95.5%, and cure rate is 72%, and is without any side effects.
Method of the present invention can effectively be come out the extracts active ingredients of every medicine, guarantees giving full play to of the property of medicine.Equal water soluble of effective ingredient of the present invention or ethanol, as equal water soluble such as the flavonoid glycoside of Herba Portulacae Grandiflorae, the carthamin of Flos Carthami, the Rhizoma Curcumae glycoside of Rhizoma Curcumae, the glycoside of the Rhizoma Pinelliae, the Saponin of Rhizoma Arisaematis, the saikoside of Radix Bupleuri or ethanol, so the present invention adopts decoction and alcohol sedimentation technique.Scorpion tail, Carapax Trionycis are valuable medicinal, are used as medicine with former powder, can better bring into play curative effect.The present invention adopts orthogonal design to investigate amount of water, decocting time, the influence of pure heavy concentration to extracting, and optimum is described amount of water of method of the present invention and decocting time, alcohol precipitation concentration 60%.
Below in conjunction with embodiment the present invention is further described.
Embodiment 1:
The prescription of this medicine and proportioning are: scorpion tail 30 grams, Herba Portulacae Grandiflorae 100 grams, Herba humuli scandentis 100 grams, the Rhizoma Atractylodis Macrocephalae 80 grams, Semen Coicis 80 grams, the Rhizoma Pinelliae 80 grams, Rhizoma Arisaematis 80 grams, Rhizoma Corydalis 80 grams, Flos Carthami 80 grams, Rhizoma Curcumae 80 grams, Carapax Trionycis 60 grams, Radix Et Rhizoma Rhei 80 grams.
A. get the raw materials ready according to top prescription and proportioning, it is standby then scorpion tail, Carapax Trionycis to be ground into fine powder, and it is even that all the other every medicines give as one thinks fit cataclasm back to mix to play the part of, and adds 15 times water again, decocts 2.5 hours;
B. after obtaining filtrate, in compound, add 5 times water again, decocted 1 hour;
C. merging filtrate, concentrated filtrate to relative density is the clear paste of 1.10-1.15, puts cold;
D. in clear paste, slowly add concentration and be 95% ethanol, make to contain the alcohol amount and reach 60%, fully stir, left standstill 24 hours;
E. filter, reclaim ethanol, concentrated medicament is the clear paste of 1.35-1.40 to relative density;
F. be fine powder with grinding after the clear paste drying, add the former powder of scorpion tail, Carapax Trionycis that has prepared again, add water and granulate, drying is made finished product.
Embodiment 2:
The prescription of this medicine and proportioning are: scorpion tail 20 grams, Herba Portulacae Grandiflorae 100 grams, Herba humuli scandentis 100 grams, the Rhizoma Atractylodis Macrocephalae 80 grams, Semen Coicis 80 grams, the Rhizoma Pinelliae 80 grams, Rhizoma Arisaematis 80 grams, Rhizoma Corydalis 80 grams, Flos Carthami 80 grams, Rhizoma Curcumae 80 grams, Carapax Trionycis 60 grams, Radix Et Rhizoma Rhei 80 grams, Radix Bupleuri 60 grams, Radix Curcumae 60 grams.
A. get the raw materials ready according to top prescription and proportioning, it is standby then scorpion tail, Carapax Trionycis to be ground into fine powder, and it is even that all the other every medicines give as one thinks fit cataclasm back to mix to play the part of, and adds 15 times water again, decocts 2.5 hours;
B. after obtaining filtrate, in compound, add 5 times water again, decocted 1 hour;
C. merging filtrate, concentrated filtrate to relative density is the clear paste of 1.10-1.15, puts cold;
D. in clear paste, slowly add concentration and be 95% ethanol, make to contain the alcohol amount and reach 60%, fully stir, left standstill 24 hours;
E. filter, reclaim ethanol, concentrated medicament is the clear paste of 1.35-1.40 to relative density;
F. be fine powder with grinding after the clear paste drying, add the former powder of scorpion tail, Carapax Trionycis that has prepared again, add water and granulate, drying is made finished product.
Compare with embodiment 1 in the present embodiment and added Radix Bupleuri and two medicines of Radix Curcumae, this is in order to solve stagnation of QI due to depression of the liver, qi depression to blood stasis, and the effect of Radix Bupleuri and Radix Curcumae is to be used for depressed liver-energy dispersing and QI regulating.
Embodiment 3: the prescription of this medicine and proportioning are: scorpion tail 25 grams, Herba Portulacae Grandiflorae 100 grams, Herba humuli scandentis 100 grams, the Rhizoma Atractylodis Macrocephalae 80 grams, Semen Coicis 80 grams, the Rhizoma Pinelliae 80 grams, Rhizoma Arisaematis 80 grams, Rhizoma Corydalis 80 grams, Flos Carthami 80 grams, Rhizoma Curcumae 80 grams, Carapax Trionycis 60 grams, Radix Et Rhizoma Rhei 80 grams, Squama Manis 60 grams, the Radix Angelicae Dahuricae 80 grams, Moschus 3 grams.
A. get the raw materials ready according to top prescription and proportioning.It is standby that scorpion tail, Carapax Trionycis, Squama Manis, Moschus are ground into fine powder, and it is even that all the other every medicines give as one thinks fit cataclasm back to mix to play the part of, and adds 15 times water again, decocted 2.5 hours;
B. after obtaining filtrate, in compound, add 5 times water again, decocted 1 hour;
C. merging filtrate, concentrated filtrate to relative density is the clear paste of 1.10-1.15, puts cold;
D. slowly add concentration and be 95% ethanol in clear paste, make to contain the alcohol amount and reach 60%, gram divides and stirs, and leaves standstill 24 hours;
E. filter, reclaim ethanol, concentrated medicament is the clear paste of 1.35-1.40 to relative density;
F. be fine powder with grinding after the clear paste drying, add the former powder of scorpion tail, Carapax Trionycis, Squama Manis, Moschus that has prepared again, granulate with rice vinegar, drying is made finished product.
The purpose that adds Squama Manis, the Radix Angelicae Dahuricae, Moschus in the present embodiment is: Squama Manis can be taken medicine and go into brain, and Radix Angelicae Dahuricae fragrance ends headache, and the Moschus refreshment of having one's ideas straightened out is mainly used in the treatment cerebroma.The effect of granulating with rice vinegar is: penetration is strong, medicine is beneficial to enters brain tumor barrier, strengthens therapeutic effect.
Claims (5)
1, a kind of Katsutoxin pill for tumor is characterized in that: the prescription of this medicine and proportioning are: scorpion tail 20-30 gram, Herba Portulacae Grandiflorae 80-120 gram, Herba humuli scandentis 80-120 gram, Rhizoma Atractylodis Macrocephalae 60-100 gram, Semen Coicis 60-100 gram, Rhizoma Pinelliae 80-100 gram, Rhizoma Arisaematis 80-100 gram, Rhizoma Corydalis 80-100 gram, Flos Carthami 80-100 gram, Rhizoma Curcumae 80-100 gram, Carapax Trionycis 60-80 gram, Radix Et Rhizoma Rhei 80-100 gram.
2, a kind of Katsutoxin pill for tumor according to claim 1, it is characterized in that: the prescription of this medicine and proportioning can also be: scorpion tail 20-30 gram, Herba Portulacae Grandiflorae 80-120 gram, Herba humuli scandentis 80-120 gram, Rhizoma Atractylodis Macrocephalae 60-100 gram, Semen Coicis 60-100 gram, Rhizoma Pinelliae 80-100 gram, Rhizoma Arisaematis 80-100 grams, Rhizoma Corydalis 80-100 gram, Flos Carthami 80-100 gram, Rhizoma Curcumae 80-100 gram, Carapax Trionycis 60-80 gram, Radix Et Rhizoma Rhei 80-100 gram, Radix Bupleuri 50-80 gram, Radix Curcumae 50-80 gram.
3, a kind of Katsutoxin pill for tumor according to claim 1 is characterized in that: the assembly analogy of this medicine can also be: scorpion tail 20-30 gram, Herba Portulacae Grandiflorae 80-120 gram Herba humuli scandentis 80-120 gram, Rhizoma Atractylodis Macrocephalae 60-100 gram, Semen Coicis 60-100 gram, Rhizoma Pinelliae 80-100 gram, Rhizoma Arisaematis 80-100 gram, Rhizoma Corydalis 80-100 gram, Flos Carthami 80-100 gram, Rhizoma Curcumae 80-100 gram, Carapax Trionycis 60-80 gram, Radix Et Rhizoma Rhei 80-100 gram, Squama Manis 60-80 gram, Radix Angelicae Dahuricae 80-100 gram, Moschus 3-5 gram.
4, a kind of preparation method of Katsutoxin pill for tumor is characterized in that:
A. get the raw materials ready according to following prescription and proportioning: the prescription of this medicine and proportioning are: scorpion tail 20-30 gram, Herba Portulacae Grandiflorae 80-120 gram, Herba humuli scandentis 80-120 gram, Rhizoma Atractylodis Macrocephalae 60-100 gram, Semen Coicis 6-100 gram, Rhizoma Pinelliae 80-100 gram, Rhizoma Arisaematis 80-100 gram, Rhizoma Corydalis 80-100 gram, Flos Carthami 80-100 gram, Rhizoma Curcumae 80-100 gram, Carapax Trionycis 60-80 gram, Radix Et Rhizoma Rhei 80-100 gram.It is standby that scorpion tail, Carapax Trionycis are ground into fine powder, and it is even that all the other every medicines give as one thinks fit cataclasm back to mix to play the part of, and adds 15 times water again, decocted 2.5 hours;
B. after obtaining filtrate, in compound, add 5 times water again, decocted 1 hour;
C. merging filtrate, concentrated filtrate to relative density is the clear paste of 1.10-1.15, puts cold;
D. in clear paste, slowly add concentration and be 95% ethanol, make to contain the alcohol amount and reach 60%, fully stir, left standstill 24 hours;
E. filter, reclaim ethanol, concentrated medicament is the clear paste of 1.35-1.40 to relative density;
F. be fine powder with grinding after the clear paste drying, add the former powder of scorpion tail, Carapax Trionycis that has prepared again, add water and granulate, drying is made finished product.
5, the preparation method of a kind of Katsutoxin pill for tumor according to claim 4 is characterized in that:
A. get the raw materials ready according to following prescription and proportioning: the prescription of this medicine and proportioning are: scorpion tail 20-30 gram, Herba Portulacae Grandiflorae 80-120 gram Herba humuli scandentis 80-120 gram, Rhizoma Atractylodis Macrocephalae 60-100 gram, Semen Coicis 60-100 gram, Rhizoma Pinelliae 80-100 gram, Rhizoma Arisaematis 80-100 gram, Rhizoma Corydalis 80-100 gram, Flos Carthami 80-100 gram, Rhizoma Curcumae 80-100 gram, Carapax Trionycis 60-80 gram, Radix Et Rhizoma Rhei 80-100 gram, Squama Manis 60-80 gram, Radix Angelicae Dahuricae 80-100 gram, Moschus 3-5 gram.It is standby that scorpion tail, Carapax Trionycis, Squama Manis, Moschus are ground into fine powder, and it is even that all the other every medicines give as one thinks fit cataclasm back to mix to play the part of, and adds 15 times water again, decocted 2.5 hours;
B. after obtaining filtrate, in compound, add 5 times water again, decocted 1 hour;
C. merging filtrate, concentrated filtrate to relative density is the clear paste of 1.10-1.15, puts cold;
D. in clear paste, slowly add concentration and be 95% ethanol, make to contain the alcohol amount and reach 60%, fully stir, left standstill 24 hours;
E. filter, reclaim ethanol, concentrated medicament is the clear paste of 1.35-1.40 to relative density;
F. be fine powder with grinding after the clear paste drying, add the former powder of scorpion tail, Carapax Trionycis, Squama Manis, Moschus that has prepared again, granulate with rice vinegar, drying is made finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97120965A CN1059117C (en) | 1997-11-25 | 1997-11-25 | Katsutoxin pill for tumor and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97120965A CN1059117C (en) | 1997-11-25 | 1997-11-25 | Katsutoxin pill for tumor and preparing method thereof |
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| Publication Number | Publication Date |
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| CN1183297A true CN1183297A (en) | 1998-06-03 |
| CN1059117C CN1059117C (en) | 2000-12-06 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN97120965A Expired - Fee Related CN1059117C (en) | 1997-11-25 | 1997-11-25 | Katsutoxin pill for tumor and preparing method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8197868B2 (en) | 2007-11-19 | 2012-06-12 | Bionovo, Inc. | Process of making purified extract of Scutellaria barbata D. Don |
| CN103169919A (en) * | 2013-03-12 | 2013-06-26 | 张成全 | Pharmaceutical composition for treating brain tumor and preparation method thereof |
| US8512961B2 (en) | 2007-11-19 | 2013-08-20 | Bionovo, Inc. | Methods of detecting and treatment of cancers using Scutellaria barbata extract |
| US9155770B2 (en) | 2007-09-07 | 2015-10-13 | Bionovo, Inc. | Estrogenic extracts of Scuttelaria barbata D. don of the labiatae family and uses thereof |
-
1997
- 1997-11-25 CN CN97120965A patent/CN1059117C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9155770B2 (en) | 2007-09-07 | 2015-10-13 | Bionovo, Inc. | Estrogenic extracts of Scuttelaria barbata D. don of the labiatae family and uses thereof |
| US8197868B2 (en) | 2007-11-19 | 2012-06-12 | Bionovo, Inc. | Process of making purified extract of Scutellaria barbata D. Don |
| US8512961B2 (en) | 2007-11-19 | 2013-08-20 | Bionovo, Inc. | Methods of detecting and treatment of cancers using Scutellaria barbata extract |
| CN103169919A (en) * | 2013-03-12 | 2013-06-26 | 张成全 | Pharmaceutical composition for treating brain tumor and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN1059117C (en) | 2000-12-06 |
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