CN109939191A - Chinese medicine composition, preparation method and the application of bone marrow suppression after a kind of antagonism chemotherapy of tumors - Google Patents
Chinese medicine composition, preparation method and the application of bone marrow suppression after a kind of antagonism chemotherapy of tumors Download PDFInfo
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Abstract
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of Chinese medicine composition of bone marrow suppression after antagonism chemotherapy of tumors, its effective component includes drug A and drug B, wherein: drug A includes following bulk pharmaceutical chemicals in parts by weight: 50 ~ 75 parts of Radix Astragali, 10 ~ 25 parts of Radix Angelicae Sinensis, 10 ~ 30 parts of Radix Codonopsis, 10 ~ 30 parts of Chinese yam, 10 ~ 30 parts of Poria cocos, 30 ~ 60 parts of Caulis Spatholobi, 10 ~ 30 parts of rhizoma polygonati, 5 ~ 15 parts of costus root, 10 ~ 30 parts of Semen Ziziphi Spinosae (parched), 10 ~ 20 parts of fushen, 10 ~ 30 parts of honey polygala root, 20 ~ 60 parts of Rhizoma Atractylodis Macrocephalae, fry 10 ~ 30 parts of rice bud, 10 ~ 30 parts of coloured malt;Drug B includes following bulk pharmaceutical chemicals in parts by weight: 20 ~ 30 parts of tortoise-shell glue, 10 ~ 30 parts of deer horn glue, 10 ~ 30 parts of donkey-hide gelatin, 10 ~ 30 parts of fructus lycii, 10 ~ 30 parts of American Ginseng, 20 ~ 40 parts of the root of straight ladybell.The effect of Chinese medicine composition of bone marrow suppression after antagonism chemotherapy of tumors disclosed in this invention is a kind of completely new Chinese medicine preparation, distinguishes time-choosing medicating according to midnight-noon and ebb-flow doctrine and be used cooperatively, reaches strengthening spleen, tonifying kidney, nourishing qi and blood, replenishing essence life marrow, clinical application is significant in efficacy.
Description
Technical field
The invention belongs to technical field of Chinese medicine, and in particular to the Chinese traditional medicine composition of bone marrow suppression after a kind of antagonism chemotherapy of tumors
Object, preparation method and its application.
Background technique
Chinese medicine thinks that chemotherapeutics category " poisoning of drug ", easy yin-damaging and Qi consuming damages smart blood trouble, leads to visceral dysfunction, serious shadow
Source of generating QI and blood is rung, the disease of deficiency of qi and blood occurs, therefore cytopenia category asthenic symptoms scope, main pathogenesis caused by chemotherapy
It is in close relations with spleen kidney, therefore strengthening spleen, tonifying kidney, nourishing qi and blood, the raw marrow of replenishing essence are controlling substantially for bone marrow suppression caused by mitigating chemotherapy
Then.
Wherein, patent CN101612248A discloses a kind of Chinese medicine for treating bone marrow suppression, and Radix Astragali is qi-invigorating herb in side,
Body immunity can be improved;Radix Angelicae Sinensis energy replenishing and activating blood, Radix Rehmanniae and radix rehmanniae preparata energy qi-restoratives damage, warming the middle warmer and descending qi, promoting blood circulation;The fruit of glossy privet and too
Son ginseng is tonic, is used for the deficiency of liver-yin and kidney-yin;Fleece-flower root energy blood-nourishing benefit liver, controlling nocturnal emission with astringent drugs kidney-nourishing, muscle reinforcing and bone strengthening, the enriching yin of tortoiseshell energy, checking exuberance of yang, benefit
Kidney, strong bone, donkey-hide gelatin can enrich blood, stop blooding, nourishing Yin and moistening dryness.Above-mentioned all medicine compatibility plays mutually synergistic effect, controls qi-blood deficiency, reaches
The effect of nourishing qi and blood, strengthening spleen, tonifying kidney, replenishing essence life marrow.
(2014,34 (7): Jilin traditional Chinese medicine 705~706) closes Liuwei Dihuang Wan plus-minus treatment evening with guipi decoction to Liu Xue etc.
Phase lung cancer chemotherapy bone marrow suppression, totally 24 taste medicine in side: ginseng 20g, tortoiseshell 15g, astragalus root 30g, Poria cocos 15g, rhizoma atractylodis macrocephalae 15g,
Rehmannia glutinosa 30g, Chinese yam 30g, rhizoma polygonati 15g, Fructus Corni 15g, fructus lycii 15g, fruit of glossy privet 15g, oldenlandia diffusa 15g, radix ranunculi ternati
15g, Snakegourd Seed 30g, fructus cannabis 15g, keel 30g, oyster 30g, clear water tuber of pinellia 20g, Cortex Magnoliae Officinalis 15g, radish seed 30g, endothelium corneum gigeriae galli
10g, Inula britannica chinensis 15g, ochre 15g, radix aucklandiae 10g.The party is to treat big method with kidney and spleen invigorating, first is that tonifying spleen, makes the prosperous then qi and blood of spleen
It is biochemical active;Second is that strengthening spleen, tonifying kidney, qi-blood tonifying.
Patent CN107661468A disclose it is a kind of treat Mammary cancer bone marrow suppression Chinese medicine, by the raw material of following parts by weight
Composition: 10~30 parts of Radix Codonopsis, 6~15 parts of psoralea corylifolia, 13~28 parts of Herba Epimedii, 13~30 parts of Poria cocos, 13~30 parts of fructus alpiniae oxyphyllae, white
6~19 parts of art, 5~17 parts of tortoise plastron, 13~25 parts of endothelium corneum gigeriae galli, 15~30 parts of Radix Angelicae Sinensis, 15~28 parts of Caulis Spatholobi, dried orange peel 10~20
Part, 5~17 parts of the tuber of pinellia, 9~20 parts of the fruit of glossy privet, 5~15 parts of fructus lycii.The party uses Buzhong class Chinese medicine, wherein Radix Codonopsis, white
Art etc. has the effect of activating blood circulation and supplementing qi;Psoralea corylifolia can improve the leukopenic illness generated by bone marrow suppression, improve immune
Power and resistance;Radix Astragali, tortoise plastron etc. have the function of strengthen immunity.
Finishing sea equality, (2018,26 (7): the combination of Chinese tradiational and Western medicine 60~61) adds and subtracts treatment malignant tumor patient with bazhen decoction
Bone marrow suppression after treatment takes the function of its tonifying Qi and blood, with reinforcing vital qi, " healthy tendency deposit in, heresy can not be done ".It is Radix Codonopsis in side, radix pseudostellariae, ripe
Glutinous rehmannia nourishing qi and blood is monarch drug in a prescription altogether;Rhizoma Atractylodis Macrocephalae, Poria cocos invigorating the spleen excreting dampness, Radix Angelicae Sinensis, Radix Paeoniae Alba blood-nourishing joint venture, are ministerial drug;Rhizoma Chuanxiong is adjutant,
Blood-activating and qi-promoting mends Rehmannia glutinosa, Radix Angelicae Sinensis, Radix Paeoniae Alba without stagnant;Radix glycyrrhizae preparata is to make, and QI invigorating is in, coordinating the drug actions of a prescription.All medicines share, can
Keep qi and blood vigorous, yin-yang reconciles, therefore symptom improves.
The four above documents are treated by Chinese medicine, to treat bone marrow suppression.Although, can by traditional Chinese medical herbal treatment
To be effectively improved oligoleukocythemia caused by chemotherapy or whole blood trace elements, tumor patient is set to pass through therapeutic scheme, but simultaneously
It is not that any Chinese medicine with nourishing qi and blood, tonifying spleen and kidney, the raw marrow of Psoralen, enriching kidney essence and other effects can have with arbitrary proportion combination
There is bone marrow suppression caused by improving chemotherapy.But the prior art is intended to strengthening spleen, tonifying kidney (patent CN101612248A, Liu
Learn etc.), help gas, with reinforcing vital qi (patent CN107661468A, finish extra large equality), the absorption of drug is but ignored, benefit
The drugs such as spleen, invigorating the spleen, kidney tonifying, nourishing the stomach synthesis is used together, prevent its drug effect from reaching disease position, serious shadow completely or well
Its therapeutic effect is rung.
Summary of the invention
The object of the present invention is to provide a kind of new strengthening spleen, tonifying kidney, nourishing qi and blood, the raw marrow of replenishing essence Chinese medicine composition and
Preparation method and application, the composition are significant in efficacy to bone marrow suppression disease after chemotherapy of tumors, to solve to exist in the prior art
The problem of.
According to an aspect of the invention, there is provided after a kind of antagonism chemotherapy of tumors bone marrow suppression Chinese medicine composition,
Effective component includes the drug A and drug B of different periods administration, in which:
Drug A includes following bulk pharmaceutical chemicals in parts by weight: 50~75 parts of Radix Astragali, 10~25 parts of Radix Angelicae Sinensis, and Radix Codonopsis 10~30
Part, 10~30 parts of Chinese yam, 10~30 parts of Poria cocos, 30~60 parts of Caulis Spatholobi, 10~30 parts of rhizoma polygonati, 5~15 parts of costus root, fry wild jujube
10~30 parts of benevolence, 10~20 parts of fushen, 10~30 parts of honey polygala root, 20~60 parts of Rhizoma Atractylodis Macrocephalae, 10~30 parts of rice bud of stir-fry, coloured malt 10~
30 parts;
Drug B includes following bulk pharmaceutical chemicals in parts by weight: 20~30 parts of tortoise-shell glue, 10~30 parts of deer horn glue, and donkey-hide gelatin 10
~30 parts, 10~30 parts of fructus lycii, 10~30 parts of American Ginseng, 20~40 parts of the root of straight ladybell.
The Chinese medicine composition of bone marrow suppression after antagonism chemotherapy of tumors disclosed in this invention is that the completely new Chinese medicine of one kind is matched
Side, drug A therein is based on spleen benefiting and replenishing qi and blood, and is allayed excitement with kidney tonifying, essence replenishing;Drug B reuses the in love product of flesh and blood, cooperation
The effect of drug A is used, enhancing nourishing qi and blood, replenishing essence life marrow, tonifying both YIN and YANG;The party controls from spleen kidney opinion, passes through strengthening spleen, tonifying kidney, benefit
Gas blood-nourishing can not only prevent and treat bone marrow suppression after chemotherapy, while can mitigate tumour complication itself;The invention also provides with
The method that strengthening spleen, tonifying kidney method Selecting time prevents and treats bone marrow suppression disease after chemotherapy of tumors, clinical application are significant in efficacy.
Chinese medicine composition application method of the invention is as follows:
8:00 point took medicament A, 14:00 a point and took once medicament A again morning, one dose per day, was taken in two divided doses, after meal
Half an hour is oral;Afternoon, 5:00~7:00 took medicament B, and one dose per day, half an hour is oral after meal.
Medication of the invention according to life rhythm to comply with the world when and treat disease, in 1 day 12 division of day and night with
The twelve regular channels match, every passages through which vital energy circulates have it is vigorous when, be in " when prosperous " of functional activity in certain passages through which vital energy circulates, be that it is driven away outside this internal organs
When heresy is most advantageous and most effective.Morning 7:00~9:00 qi and blood qi and blood stomach meridian, 9:00~11:00 qi and blood qi and blood the spleen channel, therefore select
It selects and takes medicament A Gu shield taste when stomach meridian is prosperous at the morning 8, yang-energy is healthy and vigorous at this time, and the transporting ability of stomach is strong, takes nourishing drug
Absorption most easy to digest.The spleen channel in season, can become the drug of absorption essence and blood and be transported to whole body to support internal organs when to 9.13:00
~15:00, in season, physiological function is reservoir and transformation and separates the useful from the waste that aqueous returns bladder, and waste matter send large intestine, essence to small intestinl channel
On be transported in spleen, in 14:00 medication drug absorption can be entered human body again when small intestinl channel is prosperous.17:00~19:00 qi and blood stream
Infuse kidney channel, therefore selection takes medicament B in 19:00 and fills up kidney essense, with up to " world it is prosperous when and eliminating evil " purpose.
Wherein, drug A is based on spleen benefiting and replenishing qi and blood, and is allayed excitement with kidney tonifying, essence replenishing, and suitable morning and noon take, mainly
Cause are as follows:
The spleen and stomach provide the material basis of the acquired, biochemical weary source, and sick and congenital kidney causes kidney essense impaired, and it is marrow suppression that marrow, which is become homeless and supported,
The key factor that disease processed occurs.The common patient's sallow complexion of clinical symptoms or white, spiritlessness and weakness, nausea and vomiting, gastral cavilty do not relax all of a sudden,
Soreness and weakness of waist and knees, dizziness, dizzy, tinnitus, pale tongue, whitish tongue, deep,thready and forceless pulse or tongue are red, and tongue fur is few, thready rapid pulse etc., this loses strong for spleen
Fortune, biochemical weary source as being the prerequisite that bone marrow suppression disease occurs, therefore while occurring bone marrow suppression disease after chemotherapy should be mended with invigorating the spleen
Kidney is fundamentum.Radix Astragali in side, Radix Codonopsis, Fu a kind of reed mentioned in ancient books, Rhizoma Atractylodis Macrocephalae, the sweet temperature of Chinese yam product invigorate the spleen and benefit qi with green blood, make that gas is prosperous and blood is raw;
Radix Angelicae Sinensis, Semen Ziziphi Spinosae (parched), the sweet temperature replenishing blood for nourishing heart of fushen;Honey polygala root antitoxic heart-soothing and sedative;Caulis Spatholobi, rhizoma polygonati blood-nourishing are enriched blood, spleen kidney giving young employees remedial-courses in general knowledge and vocational skills;Extensively
Muxiangliqi is amusing, and with a large amount of qi-benefiting and spleen-strengthening drug compatibilities, the function of multiple middle burnt transporting hinders stomach to prevent qi-replenishing and blood-enriching medicine taste is greasy, with stir-fry
Rice bud, coloured malt compatibility, make mend and it is oiliness, warm but not dry.The function that nourishing qi and blood mutually melts is played altogether, is taken when stomach meridian and prosperous small intestinl channel
Medicine can more preferably play curative effect of medication.
Drug B reuses the in love product of flesh and blood, uses with composite medicine A, enhancing nourishing qi and blood, the raw marrow of replenishing essence, tonifying both YIN and YANG it
Effect is preferably taken at dusk, is primarily due to:
Tortoise-shell glue, deer horn glue are main ingredient, return kidney channel, and " yang-energy that deer obtains the world is most complete, is apt to logical governor vessel ", angle is glue,
Taste is salty, slightly warm in nature, can kidney-replenishing, promoting vital essence and blood genernation;" the yin gas that tortoise obtains the world is most thick, is apt to logical conception vessel ", plastron is glue, and taste is salty, sweet,
It is mild-natured, it can nourishing and suppressing Yang, kidney tonifying and enriching blood;" category of two object qi and bloods, good fortune is profound micro- again, and foreign peoples is in love ", with people's then same gas phase
It asks, its non-vegetation is comparable;American Ginseng, sweet in flavor, slight bitter is cool in nature, and return heart, lung, kidney channel reinforce vital energy and promote the production of body fluid, " being good at solid gas ";
Fructus lycii, it is sweet in flavor, it is mild-natured, return liver and kidney channel, strengthening the essence green blood is nourishing liver and kidney, " being good at enriching yin ";Deer horn glue, tortoiseshell, American Ginseng, Chinese holly
Matrimony vine four traditional Chinese medicine shares, and nature and flavor are gentle, enters the five internal organs based on liver, kidney, and kind logical eight extra-channel appoints, superintends and directs, production of sperm, QI invigorating, blood-nourishing,
Tonifying both YIN and YANG, and tonifying yin and without sluggish disadvantage, yang-tonifying and without scorching evil;The root of straight ladybell is sweet, cool, clearing heat and nourishing yin, moistening lung to arrest cough, grows
Nourishing stomach-YIN, donkey-hide gelatin sweet and neutral, return lung, liver and kidney channel, nourishing yin and nourishing blood, the root of straight ladybell, donkey-hide gelatin play the function of the raw marrow of kidney tonifying altogether.
The kidney being the origin of congenital constitution, nephroyin and nephroyang of residing, and chemotherapy poisoning of drug impairing the spleen and stomach, the biochemical weary source of qi and blood, sick and congenital kidney,
Cause kidney essense impaired, it is key factor that bone marrow suppression disease occurs that marrow, which is become homeless and supported, therefore above-mentioned prescription is basic with strengthening spleen, tonifying kidney
Rule compatibility forms, with " kind yang-tonifying person, must in treating YANG within YIN, positive negative help and it is biochemical infinite;Kind tonifying yin person, must Yu Yangzhong ask
Yin, then negative positive liter and gush is inexhaustible " be principle, fundamentally improve bone marrow suppression.Increase convinced blood yin when kidney channel is prosperous
Drug B that is positive and mending, which treats the illness, can significantly improve curative effect.
It clinically finds, eighty per cant patient will appear bone marrow suppression during chemotherapy of tumors.Chemotherapy will affect marrow
The proliferation of stem cell, and then cause different type haemocyte differentiation and proliferation limited, cause the decline of variety classes blood cell composition, causes
Make the blood pictures constituent reduction such as patient's body leucocyte, red blood cell, blood platelet, to occur under pernicious anaemia, bleeding, immunologic mechanism
Phenomena such as drop.Wherein, oligoleukocythemia is the most prominent, can weaken human immunological competence, and serious infection and evil easily occurs in clinic
Property complication.According to the clinical symptoms for occurring bone marrow suppression after chemotherapy, such as dizzy out of strength, soreness and weakness of waist and knees, nausea and vomiting, receive it is poor,
This disease is classified as " consumptive disease ", " deficiency of blood ", " blood by symptoms, the Chinese medicines such as palpitaition, dysphoria in chestpalms-soles, poor dreaminess of sleeping, easy fever caused by exogenous pathogens and bleeding
The etiology and pathogenesis state of bone marrow suppression is attributed to " speen-kidney dificiency, marrow are become homeless feeding " by the scopes such as labor ", " blood trouble ", most scholar.
For this purpose, being invigorated the spleen and benefited qi in side of the invention with the product of Radix Astragali, Radix Codonopsis, Poria cocos, Rhizoma Atractylodis Macrocephalae, the sweet temperature of Chinese yam with green blood, make
Gas is prosperous and blood is raw;Radix Angelicae Sinensis, Semen Ziziphi Spinosae (parched), the sweet temperature replenishing blood for nourishing heart of fushen;Honey polygala root antitoxic heart-soothing and sedative;Caulis Spatholobi, rhizoma polygonati blood-nourishing are enriched blood,
Spleen kidney giving young employees remedial-courses in general knowledge and vocational skills;Costus root qi-regulating is amusing, with a large amount of qi-benefiting and spleen-strengthening drug compatibilities, the function of multiple middle burnt transporting, to prevent qi-replenishing and blood-enriching medicine taste
It is greasy to hinder stomach, with fry rice bud, coloured malt compatibility, make mend and it is oiliness, warm but not dry, play the function that nourishing qi and blood mutually melts altogether.Again with deer horn
Glue, tortoise-shell glue kidney-replenishing, promoting vital essence and blood genernation, with American Ginseng solid gas, fructus lycii strengthening the essence green blood, the root of straight ladybell nourishing the stomach-yin, donkey-hide gelatin nourishing yin and nourishing blood,
The function of the raw marrow of kidney tonifying is played altogether.The effect of two sides are used in combination, and reach strengthening spleen, tonifying kidney, nourishing qi and blood, replenishing essence life marrow.
In some embodiments, drug A or drug B further includes medically acceptable carriers or excipient, wherein institute
It is existing conventional techniques with carrier or excipient.
In some embodiments, drug A or drug B is tablet, capsule, pill, effervescent agent, oral solution or decoction.
According to another aspect of the present invention, the Chinese medicine composition of bone marrow suppression after a kind of antagonism chemotherapy of tumors is provided
Preparation method, specifically, when drug A is oral solution or decoction, preparation method includes the following steps:
Take Radix Astragali, Radix Angelicae Sinensis, Radix Codonopsis or radix pseudostellariae, Chinese yam, Poria cocos, Caulis Spatholobi, rhizoma polygonati, Semen Ziziphi Spinosae (parched), fushen, honey polygala root,
Rhizoma Atractylodis Macrocephalae fries rice bud, and coloured malt is mixed into mixture, is 1:10~15 plus water by solid-liquid ratio, impregnates 1~2h at normal temperature, then
Be warming up to boiling after decoct 30~40min after, be added costus root, then decoct 8~12min to get;
When drug B is oral solution or decoction, preparation method includes the following steps:
(1) fructus lycii, American Ginseng, the root of straight ladybell are mixed, by solid-liquid ratio 1:10~15 plus water, first impregnate 1~2h at normal temperature,
30~60min is decocted after then heating to boiling, is filtered to get filtrate;
(2) after pulverizing tortoise-shell glue, deer horn glue, donkey-hide gelatin respectively, filtrate molten is added.
In some embodiments, when drug A prepares oral solution or decoction, preparation method is further comprising the steps of: will
Drug A decoct 2~3 times, sterilize after filtrate is merged, be cooled to room temperature to get.
In some embodiments, when drug B prepares oral solution or decoction, the step of preparation method (1) are as follows: by fructus lycii
Son, American Ginseng, the root of straight ladybell mixing first impregnate 1~2h, after then heating to boiling by solid-liquid ratio 1:10~15 plus water at normal temperature
30~60min is decocted, is filtered to get filtrate and filter residue;Filter residue decocts 2~3 times repeatedly, uses after the filtrate decocted every time is merged.
According to a further aspect of the invention, prepared by the Chinese medicine composition for providing bone marrow suppression after antagonism chemotherapy of tumors
Treat the application after chemotherapy of tumors in bone marrow suppression drug.Specifically, the traditional chinese medicine composition of the invention is applicable not only to breast cancer, together
Sample is suitable for bone marrow suppression after other malignant tumor chemotherapies such as lung cancer, prostate cancer, gastric cancer, colon cancer, the cancer of the esophagus or liver cancer
Treatment.
Specific embodiment
The present invention will be further described in detail with reference to the specific embodiments.
The Chinese medicine composition of bone marrow suppression, is as follows the embodiment of the present invention 1~3 after antagonism chemotherapy of tumors of the invention
Component and weight.
Embodiment 1
The Chinese medicine composition of bone marrow suppression after a kind of antagonism chemotherapy of tumors, effective component include the medicine of different periods administration
Object A and drug B, in which:
Drug A includes following bulk pharmaceutical chemicals in parts by weight: 50 parts of Radix Astragali, 10 parts of Radix Angelicae Sinensis, and 10 parts of Radix Codonopsis, 10 parts of Chinese yam,
10 parts of Poria cocos, 30 parts of Caulis Spatholobi, 10 parts of rhizoma polygonati, 5 parts of costus root (under rear), 10 parts of Semen Ziziphi Spinosae (parched), 10 parts of fushen, honey polygala root 10
Part, 20 parts of Rhizoma Atractylodis Macrocephalae, fry 10 parts of rice bud, 10 parts of coloured malt;
Drug B includes following bulk pharmaceutical chemicals in parts by weight: 20 parts of tortoise-shell glue, 10 parts of deer horn glue, 10 parts of donkey-hide gelatin, fructus lycii
10 parts, 10 parts of American Ginseng, 20 parts of the root of straight ladybell.
Embodiment 2
The Chinese medicine composition of bone marrow suppression after a kind of antagonism chemotherapy of tumors, effective component include the medicine of different periods administration
Object A and drug B, in which:
Drug A includes following bulk pharmaceutical chemicals in parts by weight: 60 parts of Radix Astragali, 15 parts of Radix Angelicae Sinensis, and 20 parts of Radix Codonopsis, 20 parts of Chinese yam,
20 parts of Poria cocos, 45 parts of Caulis Spatholobi, 20 parts of rhizoma polygonati, 10 parts of costus root (under rear), 20 parts of Semen Ziziphi Spinosae (parched), 15 parts of fushen, honey polygala root 20
Part, 30 parts of Rhizoma Atractylodis Macrocephalae, fry 20 parts of rice bud, 20 parts of coloured malt;
Drug B includes following bulk pharmaceutical chemicals in parts by weight: 25 parts of tortoise-shell glue, 20 parts of deer horn glue, 20 parts of donkey-hide gelatin, fructus lycii
20 parts, 20 parts of American Ginseng, 30 parts of the root of straight ladybell.
Embodiment 3
The Chinese medicine composition of bone marrow suppression after a kind of antagonism chemotherapy of tumors, effective component include the medicine of different periods administration
Object A and drug B, in which:
Drug A includes following bulk pharmaceutical chemicals in parts by weight: 75 parts of Radix Astragali, 25 parts of Radix Angelicae Sinensis, and 30 parts of Radix Codonopsis, 30 parts of Chinese yam,
30 parts of Poria cocos, 60 parts of Caulis Spatholobi, 30 parts of rhizoma polygonati, 15 parts of costus root (under rear), 30 parts of Semen Ziziphi Spinosae (parched), 20 parts of fushen, honey polygala root 30
Part, 60 parts of Rhizoma Atractylodis Macrocephalae, fry 30 parts of rice bud, 30 parts of coloured malt;
Drug B includes following bulk pharmaceutical chemicals in parts by weight: 30 parts of tortoise-shell glue, 30 parts of deer horn glue, 30 parts of donkey-hide gelatin, fructus lycii
30 parts, 30 parts of American Ginseng, 40 parts of the root of straight ladybell.
Wherein, the Chinese medicine composition of bone marrow suppression is prepared as follows into soup after the antagonism chemotherapy of tumors of Examples 1 to 3
Agent or oral solution:
For drug A: taking Radix Astragali, Radix Angelicae Sinensis, Radix Codonopsis, Chinese yam, Poria cocos, Caulis Spatholobi, rhizoma polygonati, Semen Ziziphi Spinosae (parched), fushen, honey is far
Will, Rhizoma Atractylodis Macrocephalae fry rice bud, and coloured malt is mixed into mixture, mixture is added to the water by solid-liquid ratio 1:10, is impregnated at normal temperature
Then 2h is decocted 30 minutes at 100 DEG C, decoct 10 minutes, filter to get filtrate again after costus root is added, and is decocted 2 times repeatedly, will
Filtrate sterilizes after merging, after being cooled to room temperature, packaging.
Decoction or oral solution are prepared into for drug B:
(1) fructus lycii, American Ginseng, the root of straight ladybell are mixed, obtains mixture, is added to the water by solid-liquid ratio 1:10, first in room temperature
Lower immersion 2h, then decocts 30 minutes at 100 DEG C, decocts 2 times repeatedly, and filtering obtains filtrate;
(2) after pulverizing tortoise-shell glue, deer horn glue, donkey-hide gelatin respectively, filtrate molten is added, is stirring evenly and then adding into remaining
In filtrate, then filtration sterilization, after being cooled to room temperature, packaging.
Two different medicaments are made by different prescriptions, this two different medicament can individually be taken, can also
It is used in conjunction with each other;But clinical use effect proves, therapeutic effect when this two different medicament is used cooperatively is better than it
Therapeutic effect when a kind of middle medicament is used alone.
In order to verify the effect that drug of the present invention is used to treat bone marrow suppression disease after chemotherapy of tumors, it is with breast cancer disease
Example, is tested as follows and is evaluated its therapeutic effect.
1, subjects
90 patient with breast cancers are randomly divided into three groups, every group 30, respectively treat one group, treatment two groups and control group.
2, administration mode
Treat one group: 8 points of morning takes the drug A in an embodiment 1, and 2 pm takes once the medicine in embodiment 1 again
Object A, drug A is with being decocted in water for oral dose, and one dose per day, is taken in two divided doses, and half an hour is oral after meal;7 points of medicines taken in embodiment 1 at night
Object B, drug B is with being decocted in water for oral dose, and one dose per day, half an hour is oral after meal.
Treat two groups: 8 points of morning, 2 pm, 7 points 3 time points take the drug A in embodiment 1, medicine respectively at night
Object A is with being decocted in water for oral dose, and one dose per day, takes in three times, and half an hour is oral after meal.
Control group: the drug A in embodiment 1 is with being decocted in water for oral dose, and one dose per day, 2 sub-services of decocting, Time of Administration is random.
Three groups of patients take medicine since chemotherapy the 3rd day to chemotherapy the 20th day;1 day before chemotherapy, chemotherapy the 3rd, 7,10,20
It detects the whole blood count of three groups of patients respectively, compares different dosing regimes and makees to the prevention and treatment of bone marrow suppression disease after chemotherapy
With.
3, test result
After three kinds of Regimen Chemotherapies, three groups of generation leucocyte bone marrow suppression case loads are more as shown in table 1, by number in table 2
According to comparison as can be seen that at chemotherapy the 7th day, the 10th day, treats one group of leucocyte inhibition level and is less than treatment two groups and control group,
Two groups are treated less than control group, difference is statistically significant (P < 0.05).
The case load of the 7th, 10,20 day three groups of leucocyte degree (WHO) compares after 1 chemotherapy of table
The results are shown in Table 2 for three groups of generation neutrophil leucocyte bone marrow suppression case loads, compared by data in table 2 it is found that
Chemotherapy the 10th day, one group of neutrophil leucocyte inhibition level was treated less than treatment two groups and control group, two groups for the treatment of are less than control group,
Difference is statistically significant (P < 0.05).
The case load of the 7th, 10,20 day three groups of neutrophil leucocyte inhibition level compares after 2 chemotherapy of table
Auxiliary is as shown in table 3 using the number of cases of granulocyte colony stimulating factor in chemotherapy process, and three groups are compared, and treats one group
Medication number of cases (5) less than treatment two groups (7) and control group (9), are treated two groups and are less than control group, difference has statistics
Meaning (P < 0.05).
3 three groups of table are remedied shengbai drug with table
Group | Number of cases | With rescue therapy (%) |
Treat one group | 30 | 5(16.7) |
Treat two groups | 30 | 7(23.3) |
Control group | 30 | 9 (23.3%) |
(t=0.7330, p=0.0484)
Show that the present invention passes through Radix Astragali, Radix Angelicae Sinensis, Radix Codonopsis, Chinese yam, Poria cocos, Caulis Spatholobi, wide wood by above-mentioned experimental data
Perfume, rhizoma polygonati, Semen Ziziphi Spinosae (parched), fushen, honey polygala root, Rhizoma Atractylodis Macrocephalae, the compatibility for frying rice bud, coloured malt these bulk pharmaceutical chemicals, it is anti-tumor to treating
Bone marrow suppression disease has good effect after treatment, when the prescription and tortoise-shell glue, deer horn glue, donkey-hide gelatin, fructus lycii, American Ginseng, the root of straight ladybell this
Medicament prepared by Six-element medicine when being taken with reasonable time coordination, has bone marrow suppression disease after treatment chemotherapy of tumors more aobvious
The effect of work.
Above-described is only some embodiments of the present invention.For those of ordinary skill in the art, not
Under the premise of being detached from the invention design, various modifications and improvements can be made, these belong to protection model of the invention
It encloses.
Claims (8)
1. the Chinese medicine composition of bone marrow suppression after antagonism chemotherapy of tumors, which is characterized in that its effective component includes drug A and drug
B, in which:
Drug A includes following bulk pharmaceutical chemicals in parts by weight: 50~75 parts of Radix Astragali, 10~25 parts of Radix Angelicae Sinensis, and 10~30 parts of Radix Codonopsis, Huaihe River
10~30 parts of mountain, 10~30 parts of Poria cocos, 30~60 parts of Caulis Spatholobi, 10~30 parts of rhizoma polygonati, 5~15 parts of costus root, Semen Ziziphi Spinosae (parched) 10
~30 parts, 10~20 parts of fushen, 10~30 parts of honey polygala root, 20~60 parts of Rhizoma Atractylodis Macrocephalae, 10~30 parts of rice bud are fried, coloured malt 10~30
Part;
Drug B includes following bulk pharmaceutical chemicals in parts by weight: 20~30 parts of tortoise-shell glue, 10~30 parts of deer horn glue, and donkey-hide gelatin 10~30
Part, 10~30 parts of fructus lycii, 10~30 parts of American Ginseng, 20~40 parts of the root of straight ladybell.
2. the Chinese medicine composition of bone marrow suppression after antagonism chemotherapy of tumors according to claim 1, which is characterized in that the medicine
Object A or drug B further includes medically acceptable carrier or excipient.
3. the Chinese medicine composition of bone marrow suppression after antagonism chemotherapy of tumors according to claim 1, which is characterized in that the medicine
Object A or drug B is tablet, capsule, pill, effervescent agent, oral solution or decoction.
4. the preparation method of the Chinese medicine composition of bone marrow suppression after antagonism chemotherapy of tumors as claimed in claim 3, which is characterized in that
When drug A is oral solution or decoction, preparation method includes the following steps:
Taking Radix Astragali, Radix Angelicae Sinensis, Radix Codonopsis, Chinese yam, Poria cocos, Caulis Spatholobi, rhizoma polygonati, Semen Ziziphi Spinosae (parched), fushen, honey polygala root, Rhizoma Atractylodis Macrocephalae fries rice bud,
Coloured malt mixing is 1:10~15 plus water by solid-liquid ratio, impregnates 1~2h at normal temperature, then heat to decoction 30 after boiling~
40min, be added costus root, then decoct 8-12min to get;
When drug B is oral solution or decoction, preparation method includes the following steps:
(1) fructus lycii, American Ginseng, the root of straight ladybell are mixed, by solid-liquid ratio 1:10~15 plus water, first impregnates 1~2h at normal temperature, then
30~60min is decocted after being warming up to boiling, is filtered to get filtrate;
(2) after pulverizing tortoise-shell glue, deer horn glue, donkey-hide gelatin respectively, filtrate molten is added.
5. the preparation method according to claim 4, which is characterized in that when drug A prepares oral solution or decoction, preparation side
Method is further comprising the steps of:
By drug A decoct 2~3 times, sterilize after filtrate is merged, be cooled to room temperature to get.
6. the preparation method according to claim 4, which is characterized in that when drug B prepares oral solution or decoction, preparation side
The step of method (1) are as follows:
Fructus lycii, American Ginseng, the root of straight ladybell are mixed, by solid-liquid ratio 1:10~15 plus water, 1~2h is first impregnated at normal temperature, then rises
Temperature decocts 30~60min to after boiling, and filters to get filtrate and filter residue;Filter residue decocts 2~3 times repeatedly, the filtrate that will be decocted every time
It is used after merging.
7. any one of claims 1 to 3 Chinese medicine composition answering in bone marrow suppression drug after chemotherapy of tumors is treated in preparation
With.
8. application according to claim 7, which is characterized in that the tumour be breast cancer, lung cancer, prostate cancer, gastric cancer,
Colon cancer, the cancer of the esophagus or liver cancer.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113559175A (en) * | 2021-07-15 | 2021-10-29 | 华南农业大学 | Extract for enhancing immunity and delaying senescence and preparation method thereof |
CN116712507A (en) * | 2023-08-10 | 2023-09-08 | 中国人民解放军总医院第六医学中心 | Traditional Chinese medicine composition for assisting breast cancer chemotherapy and preparation method and application thereof |
-
2019
- 2019-04-04 CN CN201910271508.8A patent/CN109939191A/en active Pending
Non-Patent Citations (3)
Title |
---|
任黎萍等: "归脾汤和龟鹿二仙汤加减治疗乳腺癌化疗后骨髓抑制50例", 《陕西中医》 * |
实用作品的店: "乳岩(乳腺癌)围手术期中医诊疗方案", 《HTTPS://WENKU.BAIDU.COM/VIEW/9FC17BA3B04E852458FB770BF78A6529647D35DB.HTML》 * |
朱华宇等: "林毅治疗乳腺癌化疗后骨髓抑制症80例用药规律分析", 《辽宁中医杂志》 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113559175A (en) * | 2021-07-15 | 2021-10-29 | 华南农业大学 | Extract for enhancing immunity and delaying senescence and preparation method thereof |
CN116712507A (en) * | 2023-08-10 | 2023-09-08 | 中国人民解放军总医院第六医学中心 | Traditional Chinese medicine composition for assisting breast cancer chemotherapy and preparation method and application thereof |
CN116712507B (en) * | 2023-08-10 | 2023-10-20 | 中国人民解放军总医院第六医学中心 | Traditional Chinese medicine composition for assisting breast cancer chemotherapy and preparation method and application thereof |
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Application publication date: 20190628 |