CN105288068A - Preparation for treatment of arteriosclerosis and preparing method thereof - Google Patents
Preparation for treatment of arteriosclerosis and preparing method thereof Download PDFInfo
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Abstract
The invention discloses a preparation for treatment of arteriosclerosis. The preparation for treatment of arteriosclerosis is prepared from, by weight, 9-15 parts of spica prunellae, 7-13 parts of flos chrysanthemi indici, 8-12 parts of ficus erecta thumb, 6-14 parts of michelia alba, 8-13 parts of luffa stem, 5-11 parts of rhizoma alismatis, 4-10 parts of cynanchum mooreanum hemsl, 8-14 parts of Chinese mesona herb, 7-12 parts of herba ecliptae, 9-13 parts of hemerocallis citrina, 3-8 parts of jasminum sambac, 9-14 parts of radix puerariae, 6-13 parts of smilax riparia, 5-12 parts of kummerowia striata and 8-15 parts of herba andrographis. The preparation for treatment of arteriosclerosis has the effects of promoting blood circulation, removing blood stasis, eliminating phlegm, lowering lipid, strengthening body resistance and reinforcing deficiency, blood vessels can be effectively expanded, the blood flow volume is increased, circulation of heart and cerebral vessels is improved, and the arteriosclerosis treatment effect is obvious; the preparation can be taken conveniently, the course of treatment is short, the effect can be achieved quickly and no side effects exist.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly one treats arteriosclerotic preparation and method for making.
Background technology
Arteriosclerosis is a kind of non-inflammation pathological changes of tremulous pulse, be ductus arteriosus wall thicken, hardening, follow the string and the general name of the narrow and small degeneration of tube chamber and proliferative lesion, common are: atherosclerosis, monckeberg's arteriosclerosis and arteriolosclerosis 3 kinds.Atherosclerosis is type common in arteriosclerosis, is the Etiological of myocardial infarction and cerebral infarction.Arteriosclerosis be with age and occur angiopathy, its rule normally adolescence occur, increase the weight of period to person in middle and old age, fall ill.Male is many compared with women, and primary disease increases gradually in China in recent years, becomes one of old people's main cause of death.
Arteriosclerotic performance depends mainly on the degree of ischemia of vascular lesion and afflicted organ, early stage arteriosclerotic's great majority nearly all without any clinical symptoms, development of hiding under being all in concealment state.For the clinical symptoms such as all more or less listless and aching, the limping of had palpitation, chest pain, uncomfortable in chest, headache, dizziness, the cool fiber crops of extremity, extremity of arteriosclerotic's great majority, vision reduction, hypomnesis, insomnia and dreamful sleep in mid-term, different patients has different symptoms.Generally show as mental and flag, palpation body surface artery is as elongated, tortuous and hardening in Temporal Artery, radial artery, brachial artery etc. can find to broaden.
Cause in the arteriosclerotic cause of disease and the most important thing is hypertension, hyperlipemia, smoking.Other such as obesity, diabetes, hypomotility, tense situation, advanced age, family's medical histories, short-tempered etc. all arteriosclerosis can be caused.In addition taking in greasy food and the food being rich in cholesterol in a large number, is the main cause that arteriosclerosis occurs.Blood cholesterol level is too much, is one of important risk factor that coronary atherosclerosis and cardiovascular disease occur.Generally all contain a certain amount of oils and fats in diet, if like the picked-up of eating rich food and don't noting other mineral at ordinary times, too much oils and fats will be made to be deposited in blood vessel wall, bring out arteriosclerosis and other cardiovascular pathological changes.
At present, treat in arteriosclerotic medicine, publication number CN104784402A(application number 201510149502.5) patent document discloses a kind of Chinese medicine for the treatment of cerebral arteriosclerosis, it is made up of following composition of raw materials: Rhizoma Chuanxiong 10-15 part, Flos Carthami 10-15 part, Sanguis Draxonis 10-15 part, Radix Notoginseng 15-20 part, Myrrha 5-10 part, Hirudo 15-20 part, Radix Paeoniae Rubra 5-10 part, Cortex Magnoliae Officinalis 5-10 part, Radix Et Rhizoma Nardostachyos 5-10 part, Radix Astragali 10-15 part, Radix Panacis Quinquefolii 5-10 part, Moschus 3-5 part, Radix Achyranthis Bidentatae 10-15 part, Rhizoma Acori Graminei 5-10 part, Caulis Trachelospermi 5-10 part, above-mentioned each component is dried, sterilization, then abundant mix homogeneously, add the water of 3-4 times of said medicine weight, intense fire steaming and decocting, to boiling, keeps boiling steaming and decocting 10-20 minute, change slow fire and boil 30-40 minute, cold filtration, gets filtrate.Got filtrate is concentrated into paste further, adopts common process to make honeyed pill.Publication number CN104547256A(application number 201310482499.X) the one that patent document discloses treat arteriosclerotic Chinese medicine, adopt following Chinese medicine proportioning production program: Radix Rehmanniae 10-15 part, Semen Plantaginis 15-20 part, Fructus Rubi 15-20 part, Poria 15-20 part, Radix Salviae Miltiorrhizae 20-30 part, Concha Haliotidis 15-25 part, Fructus Lycii 20-30 part, Fructus Gardeniae 10-15 part, Fructus Crataegi 10-20 part, Ganoderma 10-15 part, Radix Notoginseng 10-15 part, Radix Paeoniae Alba 10-15 part, Radix Scrophulariae 15-20 part, Artemisia anethoicles Mattf 10-15 part, SHENGCAO 10-15 part.Publication number CN104288392A(application number 201410622326.8) the one that patent document discloses be used for the treatment of arteriosclerotic Chinese medicine, it is prepared from by the raw medicinal material of following weight proportion: Rhizoma Acori Graminei 8 parts, Rhizoma Alismatis 7 parts, Herba Artemisiae Scopariae 13 parts, Pollen Typhae 8 parts, Radix Achyranthis Bidentatae 7 parts.
Adopt western medical treatment for arteriosclerotic treatment at present more, its majority can only take the way of blood vessel dilating, can only temporary relieve, cure the symptoms, not the disease, recovery process is very long, needs long-term prescription to treat, easy formation is to the dependency of medicine, its therapeutic effect is all undesirable, and side effect is comparatively large, causes huge injury to liver, renal function.There is therapeutic effect not significantly outstanding problem in the arteriosclerotic Chinese medicine of existing treatment, uncertain therapeutic efficacy is cut.
Summary of the invention
For the deficiencies in the prior art, an object of the present invention is to provide the arteriosclerotic preparation for the treatment of, there is blood circulation promoting and blood stasis dispelling, blood fat reducing of eliminating the phlegm, righting tonify deficiency effect, effective blood vessel dilating, increase blood flow, improve cardiovascular and cerebrovascular circulation, treatment arteriosclerosis is evident in efficacy, and taking convenience, short treating period, instant effect, have no side effect.Another object of the present invention is just to provide the preparation method of the arteriosclerotic preparation of above-mentioned treatment.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
Treat arteriosclerotic preparation, take off the primary raw material stating quality proportioning and be prepared from: Spica Prunellae 9-15 part; Flos Chrysanthemi Indici 7-13 part; Radix Fici beecheyanae 8-12 part; Flos micheliae Albae 6-14 part; Ramulus Luffae 8-13 part; Rhizoma Alismatis 5-11 part; Radix Tylophorae arenicolae 4-10 part; Herba mesonae chinensis 8-14 part; Herba Ecliptae 7-12 part; Flos Hemerocallis 9-13 part; Flos Jasmini Sambac 3-8 part; Radix Puerariae 9-14 part; Radix et Rhizoma Smilacis Ripariae 6-13 part; Herba Kummerowiae Striatae 5-12 part; Herba Andrographis 8-15 part.
Treat arteriosclerotic preparation, preferred scheme is, takes off the primary raw material stating quality proportioning and is prepared from: Spica Prunellae 11-13 part; Flos Chrysanthemi Indici 9-11 part; Radix Fici beecheyanae 9-11 part; Flos micheliae Albae 8-10 part; Ramulus Luffae 10-12 part; Rhizoma Alismatis 7-9 part; Radix Tylophorae arenicolae 6-8 part; Herba mesonae chinensis 10-12 part; Herba Ecliptae 9-11 part; Flos Hemerocallis 10-12 part; Flos Jasmini Sambac 5-7 part; Radix Puerariae 11-13 part; Radix et Rhizoma Smilacis Ripariae 9-11 part; Herba Kummerowiae Striatae 8-10 part; Herba Andrographis 11-13 part.
Treat arteriosclerotic preparation, the scheme be more preferably is, takes off the primary raw material stating quality proportioning and is prepared from: Spica Prunellae 12 parts; Flos Chrysanthemi Indici 10 parts; Radix Fici beecheyanae 10 parts; Flos micheliae Albae 9 parts; Ramulus Luffae 11 parts; Rhizoma Alismatis 8 parts; Radix Tylophorae arenicolae 7 parts; Herba mesonae chinensis 11 parts; Herba Ecliptae 10 parts; Flos Hemerocallis 11 parts; Flos Jasmini Sambac 6 parts; Radix Puerariae 12 parts; Radix et Rhizoma Smilacis Ripariae 10 parts; Herba Kummerowiae Striatae 9 parts; Herba Andrographis 12 parts.
Present invention also offers the preparation method arteriosclerotic for above-mentioned treatment preparation being made pharmaceutically acceptable powder, decoction, pill, tablet and granule.
The preparation method of the arteriosclerotic preparation powder of described treatment, step is as follows:
(1) Rhizoma Alismatis and Radix Puerariae are cleaned, section, with soaking in Mel 30-40 minute, take out, be placed in sealed plastic container, put 2-3 days in refrigerator, air-dry, pulverize, cross 140-180 mesh sieve (preferred cross 150-170 mesh sieve, be more preferably 160 mesh sieves);
(2) Flos Chrysanthemi Indici, Flos micheliae Albae, Herba mesonae chinensis, Herba Kummerowiae Striatae and Herba Andrographis are carried out Mechanical Crushing, (baking temperature of preferably freeze drying is-13 ~-10 DEG C in lyophilization, sublimation drying is 5-7 hour, be more preferably cryodesiccated baking temperature and be-12 DEG C, sublimation drying is 6 hours), take out, pulverize, cross 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(3) humus flava usta is placed in frying pan, moderate heat stirs 10-15 minute, add Spica Prunellae, Radix Fici beecheyanae, Herba Ecliptae, Flos Jasmini Sambac and Radix et Rhizoma Smilacis Ripariae, moderate heat continues the 30-40 minute that stir-fries, and takes out, dries in the air, sieve removes humus flava usta, porphyrize, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(4) Ramulus Luffae, Radix Tylophorae arenicolae and Flos Hemerocallis are placed in pot, moderate heat fries 20-30 minute, and taking-up is dried in the air cool, is placed in glass container, add 30o-40o rice wine (consumption of preferred rice wine be the 3-5 of Ramulus Luffae, Radix Tylophorae arenicolae and Flos Hemerocallis gross mass doubly, the consumption being more preferably rice wine is Ramulus Luffae, Radix Tylophorae arenicolae and Flos Hemerocallis gross mass 4 times), moistening 3-5 days, takes out, dry, smash, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(5) by step (1)-(4) gained medicated powder mix homogeneously, sterile packaged.
Instructions of taking: at every turn get 8-10g, is placed in tea bag, soaks, every day 2-3 time, 7 days courses for the treatment of by the warm waters of about 50 DEG C.
The preparation method of the arteriosclerotic preparation decoction of described treatment, step is as follows:
(1) Ramulus Luffae, Herba mesonae chinensis, Herba Kummerowiae Striatae and Herba Andrographis are carried out Mechanical Crushing, (baking temperature of preferably freeze drying is-13 ~-10 DEG C in lyophilization, sublimation drying is 5-7 hour, be more preferably cryodesiccated baking temperature and be-12 DEG C, sublimation drying is 6 hours), take out, pulverize, cross 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(2) Rhizoma Alismatis and Radix Puerariae are cleaned, section, with soaking in Mel 30-40 minute, take out, be placed in sealed plastic container, put 2-3 days in refrigerator, air-dry;
(3) be placed in frying pan by humus flava usta, moderate heat stirs 10-15 minute, and add Spica Prunellae, Radix Fici beecheyanae and Radix et Rhizoma Smilacis Ripariae, moderate heat continues the 30-40 minute that stir-fries, and takes out, dries in the air, and sieve removes humus flava usta;
(4) Herba Ecliptae and Flos Hemerocallis are placed in pot, moderate heat fries 20-30 minute, and taking-up is dried in the air cool, is placed in glass container, adds the rice wine of 30o-40o, moistening 3-5 days, takes out;
(5) Flos Chrysanthemi Indici, Flos micheliae Albae, Radix Tylophorae arenicolae and Flos Jasmini Sambac are placed in marmite, decoct with water 40-50 minute, filter, add step (2)-(4) gains, add water and continue to decoct 30-40 minute, filter, merging filtrate, adds step (1) gained medicated powder, mixing, filters, sterile packaged.
The preparation method of the arteriosclerotic preparation decoction of above-mentioned treatment, the consumption of the preferred rice wine of step (4) is 3-5 times of Herba Ecliptae and Flos Hemerocallis gross mass, and the consumption being more preferably rice wine is Herba Ecliptae and Flos Hemerocallis gross mass 4 times.
Instructions of taking: each 50-80ml, with the warm water delivery service of about 35 DEG C, every day 2-3 time, 7 days courses for the treatment of.
The preparation method of the arteriosclerotic preparation pill of described treatment, step is as follows:
(1) Ramulus Luffae, Herba mesonae chinensis, Herba Kummerowiae Striatae and Herba Andrographis are carried out Mechanical Crushing, (baking temperature of preferably freeze drying is-13 ~-10 DEG C in lyophilization, sublimation drying is 5-7 hour, be more preferably cryodesiccated baking temperature and be-12 DEG C, sublimation drying is 6 hours), take out, pulverize, cross 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(2) Rhizoma Alismatis and Radix Puerariae are cleaned, section, with soaking in Mel 30-40 minute, take out, be placed in sealed plastic container, put 2-3 days in refrigerator, air-dry;
(3) be placed in frying pan by humus flava usta, moderate heat stirs 10-15 minute, and add Spica Prunellae, Radix Fici beecheyanae and Radix et Rhizoma Smilacis Ripariae, moderate heat continues the 30-40 minute that stir-fries, and takes out, dries in the air, and sieve removes humus flava usta;
(4) Herba Ecliptae and Flos Hemerocallis are placed in pot, moderate heat fries 20-30 minute, taking-up is dried in the air cool, be placed in glass container, add 30o-40o rice wine (consumption of preferred rice wine be the 3-5 of Herba Ecliptae and Flos Hemerocallis gross mass doubly, the consumption being more preferably rice wine is Herba Ecliptae and Flos Hemerocallis gross mass 4 times), moistening 3-5 days, takes out;
(5) Flos Chrysanthemi Indici, Flos micheliae Albae, Radix Tylophorae arenicolae and Flos Jasmini Sambac are placed in marmite, decoct with water 40-50 minute, filter, add step (2)-(4) gains, add water and continue to decoct 30-40 minute, filter, merging filtrate, adds step (1) gained medicated powder, mixing, being condensed into relative density is 1.10-1.30(40 DEG C) thick paste, make pill (preferably make the pill that diameter is 3mm-5mm, be more preferably and make the pill that diameter is 4mm).
Instructions of taking: each 10-15 ball, every day 3 times, 7 days courses for the treatment of.
The preparation method of the arteriosclerotic formulation tablet of described treatment, step is as follows:
(1) Ramulus Luffae, Herba mesonae chinensis, Herba Kummerowiae Striatae and Herba Andrographis are carried out Mechanical Crushing, (baking temperature of preferably freeze drying is-13 ~-10 DEG C in lyophilization, sublimation drying is 5-7 hour, be more preferably cryodesiccated baking temperature and be-12 DEG C, sublimation drying is 6 hours), take out, pulverize, cross 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(2) Rhizoma Alismatis and Radix Puerariae are cleaned, section, with soaking in Mel 30-40 minute, take out, be placed in sealed plastic container, put 2-3 days in refrigerator, air-dry;
(3) be placed in frying pan by humus flava usta, moderate heat stirs 10-15 minute, and add Spica Prunellae, Radix Fici beecheyanae and Radix et Rhizoma Smilacis Ripariae, moderate heat continues the 30-40 minute that stir-fries, and takes out, dries in the air, and sieve removes humus flava usta;
(4) Herba Ecliptae and Flos Hemerocallis are placed in pot, moderate heat fries 20-30 minute, taking-up is dried in the air cool, be placed in glass container, add 30o-40o rice wine (consumption of preferred rice wine be the 3-5 of Herba Ecliptae and Flos Hemerocallis gross mass doubly, the consumption being more preferably rice wine is Herba Ecliptae and Flos Hemerocallis gross mass 4 times), moistening 3-5 days, takes out;
(5) Flos Chrysanthemi Indici, Flos micheliae Albae, Radix Tylophorae arenicolae and Flos Jasmini Sambac are placed in marmite, decoct with water 40-50 minute, filter, add step (2)-(4) gains, add water and continue to decoct 30-40 minute, filter, merging filtrate, adds step (1) gained medicated powder, mixing, being condensed into relative density is 1.10-1.30(40 DEG C) thick paste, make tablet.
Instructions of taking: each 2, every day 3 times, 7 days courses for the treatment of.
The preparation method of the arteriosclerotic preparation granules agent of described treatment, step is as follows:
(1) Ramulus Luffae, Herba mesonae chinensis, Herba Kummerowiae Striatae and Herba Andrographis are carried out Mechanical Crushing, (baking temperature of preferably freeze drying is-13 ~-10 DEG C in lyophilization, sublimation drying is 5-7 hour, be more preferably cryodesiccated baking temperature and be-12 DEG C, sublimation drying is 6 hours), take out, pulverize, cross 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(2) Rhizoma Alismatis and Radix Puerariae are cleaned, section, with soaking in Mel 30-40 minute, take out, be placed in sealed plastic container, put 2-3 days in refrigerator, air-dry;
(3) be placed in frying pan by humus flava usta, moderate heat stirs 10-15 minute, and add Spica Prunellae, Radix Fici beecheyanae and Radix et Rhizoma Smilacis Ripariae, moderate heat continues the 30-40 minute that stir-fries, and takes out, dries in the air, and sieve removes humus flava usta;
(4) Herba Ecliptae and Flos Hemerocallis are placed in pot, moderate heat fries 20-30 minute, taking-up is dried in the air cool, be placed in glass container, add 30o-40o rice wine (consumption of preferred rice wine be the 3-5 of Herba Ecliptae and Flos Hemerocallis gross mass doubly, the consumption being more preferably rice wine is Herba Ecliptae and Flos Hemerocallis gross mass 4 times), moistening 3-5 days, takes out;
(5) Flos Chrysanthemi Indici, Flos micheliae Albae, Radix Tylophorae arenicolae and Flos Jasmini Sambac are placed in marmite, decoct with water 40-50 minute, filter, add step (2)-(4) gains, add water and continue to decoct 30-40 minute, filter, merging filtrate, adds step (1) gained medicated powder, mixing, being concentrated into relative density is 1.10.-1.20(40 DEG C) thick paste, add simple syrup, mixing, makes uniform granule, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.
The preparation method of the arteriosclerotic preparation granules agent of above-mentioned treatment, the consumption of the preferred simple syrup of step (5) is the 5%-7% of thick paste quality, and the consumption being more preferably simple syrup is 6% of thick paste quality.
Instructions of taking: each 1 bag, every day 3 times, 7 days courses for the treatment of.
Technical advantage of the present invention is mainly reflected in:
1, invention formulation there is blood circulation promoting and blood stasis dispelling, blood fat reducing of eliminating the phlegm, righting tonify deficiency effect, effective blood vessel dilating, increase blood flow, improve cardiovascular and cerebrovascular circulation, treatment arteriosclerosis is evident in efficacy, and taking convenience, short treating period, instant effect.
2, invention formulation adopts common Chinese medicine, meets the theory of Chinese medicine, and scientific formula is reasonable, and formulated by clinic tests and repeated verification, has no side effect, and can not form drug dependence, has good economy profit social benefit.
3, invention formulation selected materials great majority are Chinese medicine material, and not containing hormone, instant effect, cure rate are high, nothing recurs, has no side effect, and generally take medicine and just can take effect for 5-7 days.
4, invention formulation reduces the accumulation of lipid to a certain extent, increases blood fluidity simultaneously, alleviates the various malaise symptoms that arteriosclerosis causes.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1treat arteriosclerotic preparation, take off the primary raw material stating weight proportion and be prepared from (getting 80g for every part): Spica Prunellae 9 parts; Flos Chrysanthemi Indici 7 parts; Radix Fici beecheyanae 8 parts; Flos micheliae Albae 6 parts; Ramulus Luffae 8 parts; Rhizoma Alismatis 5 parts; Radix Tylophorae arenicolae 4 parts; Herba mesonae chinensis 8 parts; Herba Ecliptae 7 parts; Flos Hemerocallis 9 parts; Flos Jasmini Sambac 3 parts; Radix Puerariae 9 parts; Radix et Rhizoma Smilacis Ripariae 6 parts; Herba Kummerowiae Striatae 5 parts; Herba Andrographis 8 parts.
The preparation method of the arteriosclerotic preparation powder of above-mentioned treatment, step is as follows:
(1) Rhizoma Alismatis and Radix Puerariae are cleaned, section, with soaking in Mel 35 minutes, take out, be placed in sealed plastic container, to put in refrigerator 3 days, air-dry, pulverize, cross 160 mesh sieves;
(2) Flos Chrysanthemi Indici, Flos micheliae Albae, Herba mesonae chinensis, Herba Kummerowiae Striatae and Herba Andrographis are carried out Mechanical Crushing, lyophilization (cryodesiccated baking temperature is-12 DEG C, and sublimation drying is 6 hours), take out, pulverize, cross 160 mesh sieves;
(3) be placed in frying pan by humus flava usta, moderate heat stirs 13 minutes, adds Spica Prunellae, Radix Fici beecheyanae, Herba Ecliptae, Flos Jasmini Sambac and Radix et Rhizoma Smilacis Ripariae, and moderate heat continues to stir-fry 35 minutes, takes out, dries in the air, and sieve removes humus flava usta, porphyrize, crosses 160 mesh sieves;
(4) Ramulus Luffae, Radix Tylophorae arenicolae and Flos Hemerocallis are placed in pot, moderate heat fries 25 minutes, and taking-up is dried in the air cool, is placed in glass container, add the rice wine (consumption is 4 times of Ramulus Luffae, Radix Tylophorae arenicolae and Flos Hemerocallis gross mass) of 35o, moistening 4 days, take out, dry, smash, cross 160 mesh sieves;
(5) by step (1)-(4) gained medicated powder mix homogeneously, sterile packaged.
Instructions of taking: at every turn get 10g, is placed in tea bag, soaks, every day 3 times, 7 days courses for the treatment of by the warm waters of about 50 DEG C.
embodiment 2treat arteriosclerotic preparation, take off the primary raw material stating weight proportion and be prepared from (every part of 20g): Spica Prunellae 15 parts; Flos Chrysanthemi Indici 13 parts; Radix Fici beecheyanae 12 parts; Flos micheliae Albae 14 parts; Ramulus Luffae 13 parts; Rhizoma Alismatis 11 parts; Radix Tylophorae arenicolae 10 parts; Herba mesonae chinensis 14 parts; Herba Ecliptae 12 parts; Flos Hemerocallis 13 parts; Flos Jasmini Sambac 8 parts; Radix Puerariae 14 parts; Radix et Rhizoma Smilacis Ripariae 13 parts; Herba Kummerowiae Striatae 12 parts; Herba Andrographis 15 parts.
The preparation method of the arteriosclerotic preparation decoction of above-mentioned treatment, step is as follows:
(1) Ramulus Luffae, Herba mesonae chinensis, Herba Kummerowiae Striatae and Herba Andrographis are carried out Mechanical Crushing, lyophilization (cryodesiccated baking temperature is-12 DEG C, and sublimation drying is 6 hours), take out, pulverize, cross 160 mesh sieves;
(2) Rhizoma Alismatis and Radix Puerariae are cleaned, section, with soaking in Mel 35 minutes, take out, be placed in sealed plastic container, to put in refrigerator 3 days, air-dry;
(3) be placed in frying pan by humus flava usta, moderate heat stirs 13 minutes, adds Spica Prunellae, Radix Fici beecheyanae and Radix et Rhizoma Smilacis Ripariae, and moderate heat continues to stir-fry 35 minutes, takes out, dries in the air, and sieve removes humus flava usta;
(4) Herba Ecliptae and Flos Hemerocallis are placed in pot, moderate heat fries 25 minutes, and taking-up is dried in the air cool, is placed in glass container, adds the rice wine of 35o, moistening 4 days, takes out;
(5) Flos Chrysanthemi Indici, Flos micheliae Albae, Radix Tylophorae arenicolae and Flos Jasmini Sambac are placed in marmite, decoct with water 45 minutes, filter, add step (2)-(4) gains, add water and continue decoction 35 minutes, filter, merging filtrate, adds step (1) gained medicated powder, mixing, filters, sterile packaged.
Instructions of taking: each 70ml, every day 3 times, 7 days courses for the treatment of.
model case onechina XX, man, 61 years old, people from In Shandong Weihai.Mr.'s Hua health is always very good, likes morning exercises, has a walk after retirement.Before 2 years, Mr. Hua finds oneself to be much worse than on foot in the past, walks a hundreds of rice and just feels little legs, have a rest once being eased after the meeting.After this symptom is that Progressive symmetric erythrokeratodermia increases the weight of, and is developed to walking hundreds of rice and namely occurs walking lamely, sometimes stay at home and also can think that shank is sent out cool, not only acid but also pain.So remove examination in hospital, find that the blood vessel of two legs has nearly all been blocked, be diagnosed as serious symptom arteriosclerosis, remission after hospitalization two weeks, but soon occur again similar symptom.
Take after the present invention treats 2 courses for the treatment of of arteriosclerotic preparation decoction (embodiment 2), the symptom of little legs obviously alleviates, without sense of discomfort after walking hundreds of rice.After continuing to take 2 courses for the treatment of, check finds, the blood vessel of leg blocking is substantially unimpeded, and the symptom that little legs is sent out cool seldom occurs.Later stage visits and learns and fully recover, and recovers better, not occur other malaise symptoms.
embodiment 3treat arteriosclerotic preparation, take off the primary raw material stating weight proportion and be prepared from (getting 50g for every part): Spica Prunellae 11 parts; Flos Chrysanthemi Indici 9 parts; Radix Fici beecheyanae 9 parts; Flos micheliae Albae 8 parts; Ramulus Luffae 10 parts; Rhizoma Alismatis 7 parts; Radix Tylophorae arenicolae 6 parts; Herba mesonae chinensis 10 parts; Herba Ecliptae 9 parts; Flos Hemerocallis 10 parts; Flos Jasmini Sambac 5 parts; Radix Puerariae 11 parts; Radix et Rhizoma Smilacis Ripariae 9 parts; Herba Kummerowiae Striatae 8 parts; Herba Andrographis 11 parts.
The preparation method of the arteriosclerotic preparation pill of above-mentioned treatment, step is as follows:
(1) Ramulus Luffae, Herba mesonae chinensis, Herba Kummerowiae Striatae and Herba Andrographis are carried out Mechanical Crushing, lyophilization (cryodesiccated baking temperature is-12 DEG C, and sublimation drying is 6 hours), take out, pulverize, cross 160 mesh sieves;
(2) Rhizoma Alismatis and Radix Puerariae are cleaned, section, with soaking in Mel 35 minutes, take out, be placed in sealed plastic container, to put in refrigerator 3 days, air-dry;
(3) be placed in frying pan by humus flava usta, moderate heat stirs 13 minutes, adds Spica Prunellae, Radix Fici beecheyanae and Radix et Rhizoma Smilacis Ripariae, and moderate heat continues to stir-fry 35 minutes, takes out, dries in the air, and sieve removes humus flava usta;
(4) Herba Ecliptae and Flos Hemerocallis are placed in pot, moderate heat fries 25 minutes, and taking-up is dried in the air cool, is placed in glass container, adds the rice wine (consumption is 4 times of Herba Ecliptae and Flos Hemerocallis gross mass) of 35o, moistening 4 days, takes out;
(5) Flos Chrysanthemi Indici, Flos micheliae Albae, Radix Tylophorae arenicolae and Flos Jasmini Sambac are placed in marmite, decoct with water 45 minutes, filter, add step (2)-(4) gains, add water and continue decoction 35 minutes, filter, merging filtrate, adds step (1) gained medicated powder, mixing, being condensed into relative density is 1.20(40 DEG C) thick paste, make the pill that diameter is 4mm.
Instructions of taking: each 10 balls, every day 3 times, 7 days courses for the treatment of.
embodiment 4treat arteriosclerotic preparation, take off the primary raw material stating weight proportion and be prepared from (getting 35g for every part): Spica Prunellae 13 parts; Flos Chrysanthemi Indici 11 parts; Radix Fici beecheyanae 11 parts; Flos micheliae Albae 10 parts; Ramulus Luffae 12 parts; Rhizoma Alismatis 9 parts; Radix Tylophorae arenicolae 8 parts; Herba mesonae chinensis 12 parts; Herba Ecliptae 11 parts; Flos Hemerocallis 12 parts; Flos Jasmini Sambac 7 parts; Radix Puerariae 13 parts; Radix et Rhizoma Smilacis Ripariae 11 parts; Herba Kummerowiae Striatae 10 parts; Herba Andrographis 13 parts.
The preparation method of the arteriosclerotic formulation tablet of above-mentioned treatment, step is as follows:
(1) Ramulus Luffae, Herba mesonae chinensis, Herba Kummerowiae Striatae and Herba Andrographis are carried out Mechanical Crushing, lyophilization (cryodesiccated baking temperature is-12 DEG C, and sublimation drying is 6 hours), take out, pulverize, cross 160 mesh sieves;
(2) Rhizoma Alismatis and Radix Puerariae are cleaned, section, with soaking in Mel 35 minutes, take out, be placed in sealed plastic container, to put in refrigerator 3 days, air-dry;
(3) be placed in frying pan by humus flava usta, moderate heat stirs 13 minutes, adds Spica Prunellae, Radix Fici beecheyanae and Radix et Rhizoma Smilacis Ripariae, and moderate heat continues to stir-fry 35 minutes, takes out, dries in the air, and sieve removes humus flava usta;
(4) Herba Ecliptae and Flos Hemerocallis are placed in pot, moderate heat fries 25 minutes, and taking-up is dried in the air cool, is placed in glass container, adds the rice wine (consumption is 4 times of Herba Ecliptae and Flos Hemerocallis gross mass) of 35o, moistening 4 days, takes out;
(5) Flos Chrysanthemi Indici, Flos micheliae Albae, Radix Tylophorae arenicolae and Flos Jasmini Sambac are placed in marmite, decoct with water 45 minutes, filter, add step (2)-(4) gains, add water and continue decoction 35 minutes, filter, merging filtrate, adds step (1) gained medicated powder, mixing, being condensed into relative density is 1.20(40 DEG C) thick paste, make tablet.
Instructions of taking: each 2-3 sheet, every day 3 times, 7 days courses for the treatment of.
model case twoleaf XX, female, 49 years old, people from Zibo City of Shandong Province.The two lower limb of Mrs Ye are always sent out cool, and winter is especially serious, gradually develops into intermittent claudication afterwards, all can occur waist, buttocks aches sense of discomfort after each walking.So remove examination in hospital, say it is lumbar spondylosis, give treatment one month nearly, symptom is without obvious alleviation, and effect is undesirable.Exacerbation of symptoms in this year, so remove examination in hospital, find that leg arteries, two occlusion of iliac artery are serious, be diagnosed as arteriosclerosis, after treating half wheat harvesting period, symptom is alleviated to some extent, but fails to cure always.
Take after the present invention treats 2 courses for the treatment of of arteriosclerotic preparation (embodiment 4), symptom obviously alleviates, and pain is obviously alleviated, and seldom occurs limping phenomenon after walking.So after continuing to take 2 courses for the treatment of, symptom complete incidence graph, all malaise symptoms disappear, and go to hospital to check display indices normal.Follow up a case by regular visits to middle state always better, also do not occur other malaise symptoms.
embodiment 5treat arteriosclerotic preparation, take off the primary raw material stating weight proportion and be prepared from (getting 30g for every part): Spica Prunellae 12 parts; Flos Chrysanthemi Indici 10 parts; Radix Fici beecheyanae 10 parts; Flos micheliae Albae 9 parts; Ramulus Luffae 11 parts; Rhizoma Alismatis 8 parts; Radix Tylophorae arenicolae 7 parts; Herba mesonae chinensis 11 parts; Herba Ecliptae 10 parts; Flos Hemerocallis 11 parts; Flos Jasmini Sambac 6 parts; Radix Puerariae 12 parts; Radix et Rhizoma Smilacis Ripariae 10 parts; Herba Kummerowiae Striatae 9 parts; Herba Andrographis 12 parts.
The preparation method of the arteriosclerotic preparation granules agent of above-mentioned treatment, step is as follows:
(1) Ramulus Luffae, Herba mesonae chinensis, Herba Kummerowiae Striatae and Herba Andrographis are carried out Mechanical Crushing, lyophilization (cryodesiccated baking temperature is-12 DEG C, and sublimation drying is 6 hours), take out, pulverize, cross 160 mesh sieves;
(2) Rhizoma Alismatis and Radix Puerariae are cleaned, section, with soaking in Mel 35 minutes, take out, be placed in sealed plastic container, to put in refrigerator 3 days, air-dry;
(3) be placed in frying pan by humus flava usta, moderate heat stirs 13 minutes, adds Spica Prunellae, Radix Fici beecheyanae and Radix et Rhizoma Smilacis Ripariae, and moderate heat continues to stir-fry 35 minutes, takes out, dries in the air, and sieve removes humus flava usta;
(4) Herba Ecliptae and Flos Hemerocallis are placed in pot, moderate heat fries 25 minutes, and taking-up is dried in the air cool, is placed in glass container, adds the rice wine (consumption is 4 times of Herba Ecliptae and Flos Hemerocallis gross mass) of 35o, moistening 4 days, takes out;
(5) Flos Chrysanthemi Indici, Flos micheliae Albae, Radix Tylophorae arenicolae and Flos Jasmini Sambac are placed in marmite, decoct with water 45 minutes, filter, add step (2)-(4) gains, add water and continue decoction 35 minutes, filter, merging filtrate, adds step (1) gained medicated powder, mixing, being concentrated into relative density is 1.15(40 DEG C) thick paste, add simple syrup (consumption is 6% of thick paste quality), mixing, makes uniform granule, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.
Instructions of taking: each 1 bag, every day 3 times, 7 days courses for the treatment of.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Spica Prunellae: acrid in the mouth, hardship, cold in nature.Return liver, gallbladder meridian.For the dry fruit ear of labiate Spica Prunellae.Have and relieve inflammation or internal heat, improving eyesight, eliminating stagnation, effect of detumescence.For conjunctival congestion and swelling pain, order pearl nyctalgia, has a headache dizzy, scrofula, goiter, and acute mastitis swells and ache; Thyromegaly, tuberculous lymphadenitis, cyclomastopathy, hypertension.
Flos Chrysanthemi Indici: bitter in the mouth, pungent, cold nature.Return liver, heart channel.For the dry capitulum of feverfew Herba Dendranthematis indici.There is effect of heat-clearing and toxic substances removing.For furuncle carbuncle, laryngopharynx swelling and pain, wind-fire acute conjunctivitis, the disease such as dizzy of having a headache.There is again good hypotensive effect simultaneously, can be used for the auxiliary treatment of hypertension.To staphylococcus aureus, diphtheria corynebacterium, streptococcus, bacillus pyocyaneus, puncture Shigella, influenza virus, all there is inhibitory action.
Radix Fici beecheyanae: sweet in the mouth, pungent, warm in nature.Return lung, spleen, kidney channel.For the root of moraceae plants Fructus Fici Beecheyanae.There is replenishing QI to invigorate the spleen, promoting blood circulation to remove obstruction in the collateral, effect of expelling wind and removing dampness.Weak for overstrain, lack of appetite, agalactia, insufficiency of the spleen leucorrhea, proctoptosis, menoxenia, wind syndrome of head pain, traumatic injury, rheumatic arthralgia.
Flos micheliae Albae: bitter in the mouth, pungent, slightly warm in nature.For the flower of Magnoliacea plant white orchid.There is removing dampness, circulation of qi promoting, effect of cough-relieving.For abdominal distention uncomfortable in chest, heatstroke, cough, prostatitis, leucorrhea.
Ramulus Luffae: bitter in the mouth, cold nature.GUIXIN, spleen, kidney channel.For the stem of cucurbitaceous plant Fructus Luffae or Fructus Luffae difficult to understand.There is relaxing muscles and tendons to promote blood circulation, relieving cough and resolving phlegm, effect of removing toxic substances parasite killing.For soreness of waist and knee joint, numb limbs and tense tendons, menoxenia, cough with copious phlegm, nasopharynx, gingival atrophy, tooth of sheding baby teeth.
Rhizoma Alismatis: sweet in the mouth, bitterly disappointed.Return kidney, urinary bladder channel.For the dry tuber of Notes On Alism At Aceae Rhizoma Alismatis.There is diuresis, effect of clearing away damp-heat.For dysuria, edema distension, oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria, hyperlipidemia.
Radix Tylophorae arenicolae: bitter in the mouth, micro-pungent, property is put down.Return lung meridian.The root disappeared for the spirit of asclepiadaceae plant bamboo or aerial parts.There is clearing away heat and cooling blood, function of gallbladder promoting, effect of removing toxic substances.For fever due to yin deficiency, asthenia chronic cough, spitting of blood, distending pain over the hypochondrium, vomiting and nausea, dysentery, puerperal fidgets due to deficiency, scrofula, innominate toxic swelling, snakeworm, mad dog is bitten.
Herba mesonae chinensis: sweet in the mouth, light, cold in nature.For the aerial parts of labiate Herba mesonae chinensis.Have and relieve summer heat, heat clearing away, removing heat from blood, effect of removing toxic substances.For middle person, diabetes, jaundice, has loose bowels, dysentery, hypertension, fat meat, arthralgia, acute nephritis, acute toothache, burn and scald, erysipelas, syphilis, and paint is irritated.
Herba Ecliptae: sweet in the mouth, acid, cold in nature.Return kidney, Liver Channel.For the dry aerial parts of feverfew Eclipta prostrata.There is nourishing the liver and kidney, effect of cooling blood for hemostasis.For odontoseisis, early whitening of beard and hair, vertigo and tinnitus, soreness of the waist and knees, YinXuXueRe, spits blood, epistaxis, hematuria, dysentery, metrostaxis, traumatic hemorrhage.
Flos Hemerocallis: sweet in the mouth, cool in nature.GUIXIN, liver, spleen channel.For the alabastrum of Liliaceae hemerocallis Radix hemerocalis plicatae.Containing the abundant necessary nutrient of human body such as pollen, sugar, protein, vitamin C, calcium, fat, carotene, aminoacid.There is dampness removing heat, antipyretic, effect of removing heat from blood.For oliguria with reddish urine, jaundice, chest and diaphragm dysphoria with smothery sensation, pacifies less and sleeps, bleeding hemorrhoids, carbuncle sore night.
Flos Jasmini Sambac: acrid in the mouth, micro-sweet, warm in nature.Return spleen, stomach, Liver Channel.For the flower of Oleaceae plants jasmine.There is regulating QI to relieve pain, ward off effect of dirty dissipating depression of QI.For hindering in wet method, chest and diaphragm does not relax, and dysentery is suffered from abdominal pain, dizziness headache, conjunctival congestion, sore.
Radix Puerariae: sweet in the mouth, pungent, cool in nature.Return spleen, stomach warp.For the dry root of legume pueraria lobata.There is expelling pathogenic factors from muscles for reducing heat, promote the production of body fluid, rash, effect of yang invigorating antidiarrheal.For fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, has loose bowels; Hypertension neck pain.
Radix et Rhizoma Smilacis Ripariae: sweet in the mouth, hardship, property is put down.Return liver, lung meridian.For the root and rhizome of liliaceous plant Radix et Rhizoma Smilacis Ripariae.There is wind-damp dispelling, the meridian dredging, effect of expelling phlegm for arresting cough.For rheumatism arthromyodynia, impairment caused by overstrain lumbago, traumatic injury, cough and asthma.
Herba Kummerowiae Striatae: sweet in the mouth, pungent, micro-hardship, property is put down.Return liver, spleen, lung, kidney channel.For the herb of leguminous plant Herba Kummerowiae Striatae and perpendicular hair chicken.There is heat-clearing and toxic substances removing, invigorating spleen to remove dampness, effect of promoting blood circulation and hemostasis.For cold, fever, heat-damp in summer is vomited and diarrhoea, jaundice, carbuncle furuncle, dysentery, infantile malnutrition, stranguria with blood, spitting of blood, epistaxis, traumatic injury, leucorrhea with red and white discharge.
Herba Andrographis: bitter in the mouth, cold in nature.GUIXIN, lung, large intestine, urinary bladder channel.For the dry aerial parts of acanthaceous plant Herba Andrographis.There is heat-clearing and toxic substances removing, removing heat from blood, effect of detumescence.For cold, fever, laryngopharynx swelling and pain, aphtha of the mouth and tongue, pertussis chronic cough, dysentery, the puckery pain of pyretic stranguria, carbuncle skin infection, venom.
test examplein order to verify that the present invention treats the curative effect of arteriosclerotic preparation, We conducted contrast test.Experiment sieving Patients with Carotid Atherosclerosis 200 people, is divided into matched group and experimental group randomly, and wherein experimental group has 150 people, and matched group has 50 people.Two groups of basic simlarity in sex, age, protopathy, the state of an illness etc., have comparability through statistical procedures.
Exclusion standard: the age was under-18s or more than 75 years old; To drug allergy person; Merge gouty nephropathy, renal insufficiency person; Merge severe primary disease and the insanes such as the heart, liver, kidney, brain and hemopoietic system; Curative effect or data not congruent affect the treatment evaluation or safety judgement person cannot be judged.
Experimental group is taken the present invention and is treated arteriosclerotic preparation granules agent (embodiment 5), each 1 bag, every day 3 times, 7 days courses for the treatment of.Matched group adopts other drug, as loose in soybean phospholipid, vitamin E nicotinate capsule etc., and wherein soybean phospholipid falls apart, and directly swallows or takes after mixing it with water with warm water, every day three times, each 1.5g-10g; Recommended dose: moderate and general symptom take this product 1-3 pouch every day, point takes for 2-3 time, serious symptom every day three times, each one bag.Vitamin E nicotinate capsule, oral, a 1-2 grain, 3 times on the one.
Criterion of therapeutical effect: cure: breathe hard, uncomfortable in chest, dizzy, cardio palmus shape is clearly better, angina pectoris, myocardial ischemia occur obviously to reduce, blood fat, blood pressure, Hemorheology inspection are normal; Effective: breathe hard, uncomfortable in chest, dizzy, cardio palmus shape has certain improvement, angina pectoris, myocardial ischemia occur to reduce to some extent, and blood fat, blood pressure, Hemorheology inspection obviously improve; Invalid: breathe hard, uncomfortable in chest, dizzy, cardio palmus shape without improvement, angina pectoris, myocardial ischemia often occur, and do not change even aggravation before blood fat, blood pressure, Hemorheology inspection and treatment.
Adopt the matched group of other drug and take the Comparison of therapeutic that the present invention treats the experimental group of arteriosclerotic preparation, result is as shown in table 1:
Table 1
efficacy analysis:as can be seen from Table 1, take the inefficiency that the present invention treats arteriosclerotic preparation and be only 3.33%, cure rate is up to 68.67%, effective percentage is up to 96.67%, and take the inefficiency had up to 24% of other drug, cure rate only reaches 42%, and effective percentage is also only 76%.Experiment shows that the present invention treats arteriosclerotic preparation compared with other drug, and curative effect is more remarkable, and cure rate is high, and inefficiency is low, and not easily recurs after curing.
Before experiment to 200 routine patients through color Doppler ultrasonography evenly carotid IMT in various degree, what have even has Mottling formation.The bilateral carotid arteries of Color doppler ultrasound patient is all adopted before the treatment, the intima-media thickness (IMT) of neck arteries inner membrance is measured, tube wall IMT is measured in neck arteries, measure 5 times, to average (remarks: normal value≤0.9mm, arterial wall thickens and is defined as local 1.0mm≤IMT≤1.2mm, and arteriosclerosis plaque is defined as local I MT >=1.2mm).
Before and after treatment, the change of IMT adopts t inspection, and p<0.05 is that difference has statistical significance.In experimentation, two groups of patients all do not find abnormal and other fortuitous events of obvious hepatic and renal function in the treatment and exit test, and before and after two groups of treatments, the situations of change of IMT are as shown in table 2:
Before and after table 2 liang group treatment, IMT change is compared
As can be seen from Table 2, the IMT value difference of two groups is few before the treatment, but there is larger change in two groups of IMT values after the treatment, wherein taking the experimental group that the present invention treats arteriosclerotic preparation has IMT meansigma methods 1.21mm to be originally down to 0.94mm, successful, basic close to normal level 0.9mm, can conclude that most of patients has recovered normal; And the experimental group taking other drug is only down to 1.14mm by IMT meansigma methods 1.20mm originally, DeGrain.So the successful that the present invention treats arteriosclerotic preparation is better than the effect of other drug.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or obtain undoubtedly according to the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat arteriosclerotic preparation, it is characterized in that, take off the primary raw material stating quality proportioning and be prepared from: Spica Prunellae 9-15 part; Flos Chrysanthemi Indici 7-13 part; Radix Fici beecheyanae 8-12 part; Flos micheliae Albae 6-14 part; Ramulus Luffae 8-13 part; Rhizoma Alismatis 5-11 part; Radix Tylophorae arenicolae 4-10 part; Herba mesonae chinensis 8-14 part; Herba Ecliptae 7-12 part; Flos Hemerocallis 9-13 part; Flos Jasmini Sambac 3-8 part; Radix Puerariae 9-14 part; Radix et Rhizoma Smilacis Ripariae 6-13 part; Herba Kummerowiae Striatae 5-12 part; Herba Andrographis 8-15 part.
2. preparation according to claim 1, is characterized in that, takes off the primary raw material stating quality proportioning and is prepared from: Spica Prunellae 11-13 part; Flos Chrysanthemi Indici 9-11 part; Radix Fici beecheyanae 9-11 part; Flos micheliae Albae 8-10 part; Ramulus Luffae 10-12 part; Rhizoma Alismatis 7-9 part; Radix Tylophorae arenicolae 6-8 part; Herba mesonae chinensis 10-12 part; Herba Ecliptae 9-11 part; Flos Hemerocallis 10-12 part; Flos Jasmini Sambac 5-7 part; Radix Puerariae 11-13 part; Radix et Rhizoma Smilacis Ripariae 9-11 part; Herba Kummerowiae Striatae 8-10 part; Herba Andrographis 11-13 part.
3. preparation according to claim 1, is characterized in that, takes off the primary raw material stating quality proportioning and is prepared from: Spica Prunellae 12 parts; Flos Chrysanthemi Indici 10 parts; Radix Fici beecheyanae 10 parts; Flos micheliae Albae 9 parts; Ramulus Luffae 11 parts; Rhizoma Alismatis 8 parts; Radix Tylophorae arenicolae 7 parts; Herba mesonae chinensis 11 parts; Herba Ecliptae 10 parts; Flos Hemerocallis 11 parts; Flos Jasmini Sambac 6 parts; Radix Puerariae 12 parts; Radix et Rhizoma Smilacis Ripariae 10 parts; Herba Kummerowiae Striatae 9 parts; Herba Andrographis 12 parts.
4., according to the preparation method of the arbitrary described preparation powder of claim 1-3, it is characterized in that, step is as follows:
(1) Rhizoma Alismatis and Radix Puerariae are cleaned, section, with soaking in Mel 30-40 minute, take out, be placed in sealed plastic container, put 2-3 days in refrigerator, air-dry, pulverize, cross 140-180 mesh sieve (preferred cross 150-170 mesh sieve, be more preferably 160 mesh sieves);
(2) Flos Chrysanthemi Indici, Flos micheliae Albae, Herba mesonae chinensis, Herba Kummerowiae Striatae and Herba Andrographis are carried out Mechanical Crushing, (baking temperature of preferably freeze drying is-13 ~-10 DEG C in lyophilization, sublimation drying is 5-7 hour, be more preferably cryodesiccated baking temperature and be-12 DEG C, sublimation drying is 6 hours), take out, pulverize, cross 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(3) humus flava usta is placed in frying pan, moderate heat stirs 10-15 minute, add Spica Prunellae, Radix Fici beecheyanae, Herba Ecliptae, Flos Jasmini Sambac and Radix et Rhizoma Smilacis Ripariae, moderate heat continues the 30-40 minute that stir-fries, and takes out, dries in the air, sieve removes humus flava usta, porphyrize, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(4) Ramulus Luffae, Radix Tylophorae arenicolae and Flos Hemerocallis are placed in pot, moderate heat fries 20-30 minute, and taking-up is dried in the air cool, is placed in glass container, add 30o-40o rice wine (consumption of preferred rice wine be the 3-5 of Ramulus Luffae, Radix Tylophorae arenicolae and Flos Hemerocallis gross mass doubly, the consumption being more preferably rice wine is Ramulus Luffae, Radix Tylophorae arenicolae and Flos Hemerocallis gross mass 4 times), moistening 3-5 days, takes out, dry, smash, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(5) by step (1)-(4) gained medicated powder mix homogeneously, sterile packaged.
5., according to the preparation method of the arbitrary described preparation decoction of claim 1-3, it is characterized in that, step is as follows:
(1) Ramulus Luffae, Herba mesonae chinensis, Herba Kummerowiae Striatae and Herba Andrographis are carried out Mechanical Crushing, (baking temperature of preferably freeze drying is-13 ~-10 DEG C in lyophilization, sublimation drying is 5-7 hour, be more preferably cryodesiccated baking temperature and be-12 DEG C, sublimation drying is 6 hours), take out, pulverize, cross 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(2) Rhizoma Alismatis and Radix Puerariae are cleaned, section, with soaking in Mel 30-40 minute, take out, be placed in sealed plastic container, put 2-3 days in refrigerator, air-dry;
(3) be placed in frying pan by humus flava usta, moderate heat stirs 10-15 minute, and add Spica Prunellae, Radix Fici beecheyanae and Radix et Rhizoma Smilacis Ripariae, moderate heat continues the 30-40 minute that stir-fries, and takes out, dries in the air, and sieve removes humus flava usta;
(4) Herba Ecliptae and Flos Hemerocallis are placed in pot, moderate heat fries 20-30 minute, and taking-up is dried in the air cool, is placed in glass container, adds the rice wine of 30o-40o, moistening 3-5 days, takes out;
(5) Flos Chrysanthemi Indici, Flos micheliae Albae, Radix Tylophorae arenicolae and Flos Jasmini Sambac are placed in marmite, decoct with water 40-50 minute, filter, add step (2)-(4) gains, add water and continue to decoct 30-40 minute, filter, merging filtrate, adds step (1) gained medicated powder, mixing, filters, sterile packaged.
6. preparation method according to claim 5, is characterized in that: the consumption of the preferred rice wine of step (4) is 3-5 times of Herba Ecliptae and Flos Hemerocallis gross mass, and the consumption being more preferably rice wine is Herba Ecliptae and Flos Hemerocallis gross mass 4 times.
7., according to the preparation method of the arbitrary described preparation pill of claim 1-3, it is characterized in that, step is as follows:
(1) Ramulus Luffae, Herba mesonae chinensis, Herba Kummerowiae Striatae and Herba Andrographis are carried out Mechanical Crushing, (baking temperature of preferably freeze drying is-13 ~-10 DEG C in lyophilization, sublimation drying is 5-7 hour, be more preferably cryodesiccated baking temperature and be-12 DEG C, sublimation drying is 6 hours), take out, pulverize, cross 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(2) Rhizoma Alismatis and Radix Puerariae are cleaned, section, with soaking in Mel 30-40 minute, take out, be placed in sealed plastic container, put 2-3 days in refrigerator, air-dry;
(3) be placed in frying pan by humus flava usta, moderate heat stirs 10-15 minute, and add Spica Prunellae, Radix Fici beecheyanae and Radix et Rhizoma Smilacis Ripariae, moderate heat continues the 30-40 minute that stir-fries, and takes out, dries in the air, and sieve removes humus flava usta;
(4) Herba Ecliptae and Flos Hemerocallis are placed in pot, moderate heat fries 20-30 minute, taking-up is dried in the air cool, be placed in glass container, add 30o-40o rice wine (consumption of preferred rice wine be the 3-5 of Herba Ecliptae and Flos Hemerocallis gross mass doubly, the consumption being more preferably rice wine is Herba Ecliptae and Flos Hemerocallis gross mass 4 times), moistening 3-5 days, takes out;
(5) Flos Chrysanthemi Indici, Flos micheliae Albae, Radix Tylophorae arenicolae and Flos Jasmini Sambac are placed in marmite, decoct with water 40-50 minute, filter, add step (2)-(4) gains, add water and continue to decoct 30-40 minute, filter, merging filtrate, adds step (1) gained medicated powder, mixing, be condensed into the thick paste that relative density is 1.10-1.30, make pill (preferably make the pill that diameter is 3mm-5mm, be more preferably and make the pill that diameter is 4mm).
8., according to the preparation method of the arbitrary described formulation tablet of claim 1-3, it is characterized in that, step is as follows:
(1) Ramulus Luffae, Herba mesonae chinensis, Herba Kummerowiae Striatae and Herba Andrographis are carried out Mechanical Crushing, (baking temperature of preferably freeze drying is-13 ~-10 DEG C in lyophilization, sublimation drying is 5-7 hour, be more preferably cryodesiccated baking temperature and be-12 DEG C, sublimation drying is 6 hours), take out, pulverize, cross 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(2) Rhizoma Alismatis and Radix Puerariae are cleaned, section, with soaking in Mel 30-40 minute, take out, be placed in sealed plastic container, put 2-3 days in refrigerator, air-dry;
(3) be placed in frying pan by humus flava usta, moderate heat stirs 10-15 minute, and add Spica Prunellae, Radix Fici beecheyanae and Radix et Rhizoma Smilacis Ripariae, moderate heat continues the 30-40 minute that stir-fries, and takes out, dries in the air, and sieve removes humus flava usta;
(4) Herba Ecliptae and Flos Hemerocallis are placed in pot, moderate heat fries 20-30 minute, taking-up is dried in the air cool, be placed in glass container, add 30o-40o rice wine (consumption of preferred rice wine be the 3-5 of Herba Ecliptae and Flos Hemerocallis gross mass doubly, the consumption being more preferably rice wine is Herba Ecliptae and Flos Hemerocallis gross mass 4 times), moistening 3-5 days, takes out;
(5) Flos Chrysanthemi Indici, Flos micheliae Albae, Radix Tylophorae arenicolae and Flos Jasmini Sambac are placed in marmite, decoct with water 40-50 minute, filter, add step (2)-(4) gains, add water and continue to decoct 30-40 minute, filter, merging filtrate, adds step (1) gained medicated powder, mixing, be condensed into the thick paste that relative density is 1.10-1.30, make tablet.
9., according to the preparation method of the arbitrary described preparation granules agent of claim 1-3, it is characterized in that, step is as follows:
(1) Ramulus Luffae, Herba mesonae chinensis, Herba Kummerowiae Striatae and Herba Andrographis are carried out Mechanical Crushing, (baking temperature of preferably freeze drying is-13 ~-10 DEG C in lyophilization, sublimation drying is 5-7 hour, be more preferably cryodesiccated baking temperature and be-12 DEG C, sublimation drying is 6 hours), take out, pulverize, cross 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);
(2) Rhizoma Alismatis and Radix Puerariae are cleaned, section, with soaking in Mel 30-40 minute, take out, be placed in sealed plastic container, put 2-3 days in refrigerator, air-dry;
(3) be placed in frying pan by humus flava usta, moderate heat stirs 10-15 minute, and add Spica Prunellae, Radix Fici beecheyanae and Radix et Rhizoma Smilacis Ripariae, moderate heat continues the 30-40 minute that stir-fries, and takes out, dries in the air, and sieve removes humus flava usta;
(4) Herba Ecliptae and Flos Hemerocallis are placed in pot, moderate heat fries 20-30 minute, taking-up is dried in the air cool, be placed in glass container, add 30o-40o rice wine (consumption of preferred rice wine be the 3-5 of Herba Ecliptae and Flos Hemerocallis gross mass doubly, the consumption being more preferably rice wine is Herba Ecliptae and Flos Hemerocallis gross mass 4 times), moistening 3-5 days, takes out;
(5) Flos Chrysanthemi Indici, Flos micheliae Albae, Radix Tylophorae arenicolae and Flos Jasmini Sambac are placed in marmite, decoct with water 40-50 minute, filter, add step (2)-(4) gains, add water and continue to decoct 30-40 minute, filter, merging filtrate, adds step (1) gained medicated powder, mixing, be concentrated into the thick paste that relative density is 1.10.-1.20, add simple syrup, mixing, makes uniform granule, be aided with pharmaceutically acceptable carrier package, the quality of every parcel is 6g.
10. preparation method according to claim 9, is characterized in that: the consumption of the preferred simple syrup of step (5) is the 5%-7% of thick paste quality, and the consumption being more preferably simple syrup is 6% of thick paste quality.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1107064A (en) * | 1994-11-21 | 1995-08-23 | 于夫 | Fat reducing pill and producing technology |
| CN1307876A (en) * | 2000-06-30 | 2001-08-15 | 任开益 | Xinmaikang medicine |
| CN1745798A (en) * | 2005-09-29 | 2006-03-15 | 杨一丁 | Granular preparation with pure Chinese medicine for treating hypertension and hyperlipemia and arterial sclerosis |
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2015
- 2015-11-10 CN CN201510758695.4A patent/CN105288068A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1107064A (en) * | 1994-11-21 | 1995-08-23 | 于夫 | Fat reducing pill and producing technology |
| CN1307876A (en) * | 2000-06-30 | 2001-08-15 | 任开益 | Xinmaikang medicine |
| CN1745798A (en) * | 2005-09-29 | 2006-03-15 | 杨一丁 | Granular preparation with pure Chinese medicine for treating hypertension and hyperlipemia and arterial sclerosis |
Non-Patent Citations (1)
| Title |
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| 魏万林: "《动脉硬化性疾病现代诊疗学》", 31 May 2015, 金盾出版社 * |
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