CN1307876A

CN1307876A - Xinmaikang medicine

Info

Publication number: CN1307876A
Application number: CN00113515A
Authority: CN
Inventors: 任开益
Original assignee: Individual
Current assignee: Individual
Priority date: 2000-06-30
Filing date: 2000-06-30
Publication date: 2001-08-15
Anticipated expiration: 2020-06-30
Also published as: CN1135107C

Abstract

The present invention discloses a Chinese medicine Xinmaikang-soluble granules preparation made of 14 Chinese medicinal materials of gastrodia, salvia root, carthamus flower, chrysanthemum flower, ledebouriella root, astragalus root, ligusticum and so on through the processes of heating, decocting, concentrating, evaporative dewatering, and roasting and drying. It has no toxic side effect, and can obtain obvious therapeutic effect for curing the diseases of hypertension, hyperlipemia, high blood viscosity, cerebral arteriosclerosis, coronary heart disease, fatty lever and vertebrobasilar ischemia, etc. and can obtain the good of preventing apoplexy.

Description

Xinmaikang medicine

The present invention relates to a kind of cardiovascular diseases's of being used for Chinese medicine, particularly a kind of Chinese patent medicine that can be used for treating cardiovascular diseases and prevention of stroke.

At present, the document and the medicine of domestic existing treatment coronary heart disease and experimental atherosclerosis, " Xinmaikang medicine treatment coronary heart disease 30 examples " that the bright grade of Qin's nasal mucus is write have been published as " the Shaanxi traditional Chinese medical science " 1997.18 (3): 111, introduced by Chinese drug-treated group such as the Radix Astragali, Radix Ginseng, Radix Ophiopogonis, Ramulus Cinnamomi, Radix Puerariae, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, GUANG Radix Notoginseng, Fructus Crataegi, the Radix Polygoni Multiflori, Radix Glycyrrhizaes and become Xinmaikang medicine, treatment coronary heart disease has been had certain curative effect; " Chinese medicine research " 1996-(2) 48-49 has published " Xinmaikang medicine is to the preventive effect of Carnis Coturnicis japonicae experimental atherosclerosis " that Wu Jibiao etc. writes, introduced a kind of Xinmaikang medicine of forming by Radix Polygoni Multiflori, Rhizoma Polygonati, Pollen Tyjphae, Rhizoma Alismatis, Rhizoma Chuanxiong etc., experimental atherosclerosis has been had certain preventive effect; The Chinese Traditional Medicines of selling on the market have network glad logical etc., and its therapeutic effect has certain limitation.

In the disclosed prescriptions of Chinese medicine of Chinese medicine neutralization, be usually used in treating hypertension, the common drug of the suppressing the hyperactive liver to relieve the wind syndrome method of disease such as cerebral arteriosclerosis and hyperlipemia has: Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, Concha Haliotidis, Semen Cassiae, Herba Taxilli, Haematitum, Radix Scutellariae, Radix Gentianae, Flos Chrysanthemi, the Cortex Eucommiae, Spica Prunellae, the Radix Paeoniae Alba, Herba Leonuri, Radix Achyranthis Bidentatae etc., the common drug that is used for the resolving phlegm lowering turbidity method has: the Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Poria, Fructus Aurantii Immaturus, Caulis Bambusae In Taenia, Rhizoma Gastrodiae, the Rhizoma Atractylodis Macrocephalae, Bulbus Fritillariae Thunbergii, Rhizoma Acori Graminei, Radix Curcumae, Haematitum, Concretio Silicea Bambusae, Arisaema Cum Bile etc., the common drug that is used for the expectorant stasis of blood and method of treatment has: the Rhizoma Pinelliae, Fructus Trichosanthis, Bulbus Fritillariae Thunbergii, Arisaema Cum Bile, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Rhizoma Gastrodiae, Semen Persicae, Flos Carthami, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Rhizoma Acori Graminei, Radix Curcumae etc., the common drug that is used for the activating qi and collateral method has: the Radix Astragali, Radix Angelicae Sinensis, Semen Persicae, Flos Carthami, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, Radix Puerariae, Ramulus Cinnamomi etc., the common drug that is used for the nourishing the liver and kidney method has: the Radix Astragali, Radix Angelicae Sinensis, Semen Persicae, Flos Carthami, Rhizoma Chuanxiong, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Pheretima, Radix Salviae Miltiorrhizae, Radix Puerariae etc.

But the object of the present invention is to provide a kind of Chinese patent medicine Xinmaikang medicine that can be used for treating diseases such as hypertension, hyperlipidemia, high blood viscosity, cerebral arteriosclerosis, coronary heart disease, fatty liver and vertebral-basilar artery insufficiency and prevention of stroke.

The object of the present invention is achieved like this.With Rhizoma Gastrodiae, Flos Chrysanthemi, Concha Haliotidis, Fructus Ligustri Lucidi, Radix Rehmanniae Preparata, Radix Achyranthis Bidentatae, Rhizoma Alismatis is monarch drug, be used for suppressing the hyperactive liver and subsiding YANG, enriching yin and nourishing kidney, with Radix Salviae Miltiorrhizae, Flos Carthami, Radix Saposhnikoviae, Radix Astragali, Rhizoma Chuanxiong, Fructus Crataegi, the Cortex Eucommiae, Radix Puerariae, Scorpio, Semen Raphani is ministerial drug, being used to be turbid eliminates the phlegm, benefiting QI for activating blood circulation, invigorating the spleen and regulating the stomach, at first by the processing concocted specification crude drug in whole each component is carried out preliminary working respectively; Crude drug in whole that processing is cooked and decoction pieces drop into multi-function extractor then, the water that adds 4-8 times of drug weight, heat and decoct, 40 minutes to the 2 hours after-filtration that simmer in water after the boiling for the first time, the water that adds 2-6 times of drug weight for the second time boils after slow fire boils 30-60 minute after-filtration; Again twice filtering liquid medicine being dropped into vacuum concentrator concentrates, after concentrating, take out to drop in the jacketed pan and carry out water evaporates, put into the thermal cycle drying baker again, temperature in the drying baker is controlled between 50-65 ℃, take out after dry about 5-9 hour, absolutely dry glue sheet medicine, through purifying, add excipient and form dissolved granule again.The ratio of crude drug in whole each component (weight ratio) is: Rhizoma Gastrodiae 15-25 part, Radix Salviae Miltiorrhizae 25-35 part, Flos Carthami 1-6 part, Flos Chrysanthemi 5-15 part, Radix Saposhnikoviae 5-15 part, Radix Astragali 40-60 part, Rhizoma Chuanxiong 1-10 part, Fructus Crataegi 10-25 part, Cortex Eucommiae 5-15 part, Radix Puerariae 25-35 part, Scorpio 5-15 part, Concha Haliotidis 25-35, Rhizoma Alismatis 5-15 part, Semen Raphani 15-25.The optimum formula ratio (weight ratio) of crude drug in whole each component is: 20 parts in Rhizoma Gastrodiae, 30 parts of Radix Salviae Miltiorrhizaes, 3 parts on Flos Carthami, 10 parts of Flos Chrysanthemis, 10 parts of Radix Saposhnikoviaes, 50 parts of Radix Astragali, 6 parts of Rhizoma Chuanxiongs, 15 parts of Fructus Crataegis, 10 parts of the Cortexs Eucommiae, 30 parts of Radix Puerariaes, 10 parts of Scorpio, 30 parts of Concha Haliotidis, 10 parts of Rhizoma Alismatis, 20 parts of Semen Raphanis.

Advantage of the present invention is: the present invention is by decocting natural Chinese medicines in proportion, concentrate, making Chinese patent medicine after the operation such as evaporation, baking, it has no side effect, diseases such as apoplexy high risk patient such as hypertension, hyperlipidemia, high blood viscosity, cerebral arteriosclerosis, coronary heart disease, fatty liver and vertebral-basilar artery insufficiency there is fairly obvious curative effect, can reaches the purpose of prevention of stroke simultaneously.

Modern medicine is thought: high-risk apoplexy diseases such as hypertension, hyperlipidemia, high blood viscosity, cerebral arteriosclerosis, coronary heart disease, rheumatic heart disease, fatty liver, obesity and vertebral-basilar artery insufficiency are to cause systemic circulation anoxia and the anoxybiotic principal element of local circulation.Because brain is very responsive to anoxia, the anoxia that circulates for a long time causes symptoms such as internal respiration depletion and cerebral anoxia particularly outstanding.The present invention is by the speckle of blood pressure lowering, blood fat reducing, viscosity reduction, removing blood vessel scleratheroma, softening hardened blood vessel, blood flow increasing, improve the quality of taking oxygen of blood, improve the circulation anoxia, the depletion of correction internal respiration, thus improve the apoplexy high-risk group's be in half health status quality of life and increase work efficiency, myocardial infarction also there is the excellent prevention effect.

The present invention is except that having adopted Chinese medicine to treat in cardiovascular prescription each component commonly used and utilize its basic pharmacology, components such as the Radix Saposhnikoviae that is of little use in traditional Chinese medicine cardiovascular diseases's the prescription, Radix Puerariae, Semen Raphani have also been adopted, wherein mainly be to adopt the diffusing wind of Radix Saposhnikoviae and stimulate the menstrual flow to reach network, use together with the product that reduce phlegm with blood, and play that phlegm-fire is clear, QI and blood and effect, the property that the utilization Radix Saposhnikoviae leads to walk among the we, his medicine relieving the exterior syndrome of band we is walked network; Adopting Semen Raphani is because it has the effect of lowering the adverse-rising QI and dispelling phlegm; Adopt Radix Puerariae to be because its abnormal smells from the patient is all thin, can rise the gas of sending out the clear sun of taste, can make not reason insufficiency of vital energy and blood and withering of extremity.

Embodiment 1: with Rhizoma Gastrodiae, Flos Chrysanthemi, Concha Haliotidis, Fructus Ligustri Lucidi, Radix Rehmanniae Preparata, Radix Achyranthis Bidentatae, Rhizoma Alismatis is monarch drug, be used for suppressing the hyperactive liver and subsiding YANG, enriching yin and nourishing kidney, with Radix Salviae Miltiorrhizae, Flos Carthami, Radix Saposhnikoviae, Radix Astragali, Rhizoma Chuanxiong, Fructus Crataegi, the Cortex Eucommiae, Radix Puerariae, Scorpio, Semen Raphani is ministerial drug, being used to be turbid eliminates the phlegm, benefiting QI and nourishing blood, invigorating the spleen and regulating the stomach, amount to YIN and YANG in a relative equilibrium, spirit so that effect.Extract 20 parts in Rhizoma Gastrodiae, 30 parts of Radix Salviae Miltiorrhizaes, 3 parts on Flos Carthami, 10 parts of Flos Chrysanthemis, 10 parts of Radix Saposhnikoviaes, 50 parts of Radix Astragali, 6 parts of Rhizoma Chuanxiongs, 15 parts of Fructus Crataegis, 10 parts of the Cortexs Eucommiae, 30 parts of Radix Puerariaes, 10 parts of Scorpio, 30 parts of Concha Haliotidis, 10 parts of Rhizoma Alismatis, 20 parts of Semen Raphanis by weight, process by Hunan Province's processing concocted specification; Second step was that crude drug in whole and decoction pieces that processing cooks are dropped into multi-function extractor, the water that adds 6 times of drug weight, heat and decoct, the 60 minutes after-filtration that simmer in water after the boiling for the first time, the water that adds 4 times of drug weight for the second time 40 minutes after-filtration that simmer in water after boil; The 3rd step was dropped into vacuum concentrator with twice filtering liquid medicine, be concentrated to a certain degree and take out, drop into jacketed pan again and evaporate moisture content, when reaching about 1: 1.1 glue sap-shape, take out and put into the thermal cycle drying baker, dry the temperature inside the box is controlled between 50-65 ℃, after dry about 6 hours, take out absolutely dry glue sheet medicine, purify through conventional medicine purifying technique again, add excipient and form dissolved granule patent medicine.

Embodiment 2, and the film patent medicine that the formula proportion of embodiment 1 is made is used for clinical experiment, as the male patient Chen at 68 years old, excuse dusk, weak, hypomnesis, bradykinesia is more than 10 years, look into BP 160/90mmHg, refreshing clear, spirit is poor, face is purple dark, the build obesity, and the cervical vertebra neck is bent side pressure test (+), two pulmonary respiration sounds are clear, heart rate 80 times/minute, and rule is neat, abdominal tympanites, liver spleen do not lay one's hand on and, nervous system is not drawn pathologic reflex and is levied; Three of blood fat in the experimental data are: TG:1.748 TCH:6.821 HDL:1.45, and the cervical vertebra sheet is: six hyperosteogeny of cervical vertebra fourth, fifth,, electrocardiogram is shown: the ST section changes, and CT shows: cerebral arteriosclerosis.Be diagnosed as: hypertension, cerebral arteriosclerosis, cervical spondylosis, hyperlipemia.At this disease, every day, each 25 grams were after the treatment 45 to patient's this bright electuary secondary of taking after mixing it with water, dizzy, weak being clearly better, memory is recovered, and reaction is quick, and is refreshing clear, mental status takes a turn for the better, blood pressure maintains about 120/80mmHg, and the check electrocardiogram is roughly normal, and three checks of blood fat are: TG:1.217 TCH:4.181 HDL:1.13.Prove from present embodiment, the present invention to coronary dilating, blood fat reducing, protect diseases such as the heart, adjust blood pressure, improvement giddy, weak, hypomnesis, bradykinesia positive effect arranged.

Embodiment 3, and the film patent medicine that the formula proportion of embodiment 1 is made is used for clinical experiment, as the female patient Tan at 52 years old, excuse dusk, headache, right upper extremity is numb more than 2 years, and is refreshing clear, the asthenia face is looked into BP 160/100mmHg, and neck is bent side pressure test (+), the cervical vertebra tenderness, two pulmonary respiration sounds are clear, heart rate 55 times/minute, rule is neat, sound can, abdominal tympanites was found hypertension 5 years; ECG in the experimental data: sinus bradycardia, three of blood fat are: TG:3.607 TCH:5.972 HDL:1.03, cervical vertebra X sheet is: six hyperosteogeny of cervical vertebra fourth, fifth,, B ultrasonic shows: fatty liver.Be diagnosed as: hypertension, hyperlipemia, bradycardia, cervical spondylosis.At this disease, every day is to patient's electuary secondary of the present invention of taking after mixing it with water, each 25 grams, after the treatment 45, giddy, headache and right upper extremity numbness are clearly better, and refreshing clear, in high spirits, blood pressure maintains about 120/80mmHg, heart rate is 68 times/minute, and three checks of blood fat are: TG:1.952 TCH:5.102 HDL:1.31.Prove that from present embodiment the present invention has significant curative effect to diseases such as hypertension, hyperlipemia, bradycardia, cervical spondylosiss.

At dizzy, weak, hypomnesis, thinking respond go down, the patient of symptom such as fat, uncomfortable in chest, cardiopalmus, insomnia, hypertension, hyperlipemia, every day is to patient's electuary secondary of the present invention of taking after mixing it with water, each 25 grams, 30 days is a course of treatment, after taking three courses of treatment altogether, all pathological changes symptoms all can disappear or alleviate.By to the clinical observation of 1746 examples nearly, effective percentage reaches 98%.

Claims

1, a kind of Xinmaikang medicine, it is characterized in that: with Rhizoma Gastrodiae, Flos Chrysanthemi, Concha Haliotidis, Fructus Ligustri Lucidi, Radix Rehmanniae Preparata, Radix Achyranthis Bidentatae, Rhizoma Alismatis is monarch drug, be used for suppressing the hyperactive liver and subsiding YANG, enriching yin and nourishing kidney, with Radix Salviae Miltiorrhizae, Flos Carthami, Radix Saposhnikoviae, Radix Astragali, Rhizoma Chuanxiong, Fructus Crataegi, the Cortex Eucommiae, Radix Puerariae, Scorpio, Semen Raphani is ministerial drug, being used to be turbid eliminates the phlegm, benefiting QI for activating blood circulation, invigorating the spleen and regulating the stomach, at first by the processing concocted specification crude drug in whole each component is carried out preliminary working respectively; Crude drug in whole that processing is cooked and decoction pieces drop into multi-function extractor then, the water that adds 4-8 times of drug weight, heat and decoct, 40 minutes to the 2 hours after-filtration that simmer in water after the boiling for the first time, the water that adds 2-6 times of drug weight for the second time boils after slow fire boils 30-60 minute after-filtration; Again twice filtering liquid medicine being dropped into vacuum concentrator concentrates, after concentrating, take out to drop in the jacketed pan and carry out water evaporates, put into the thermal cycle drying baker again, temperature in the drying baker is controlled between 50-65 ℃, take out after dry about 5-9 hour, absolutely dry glue sheet medicine, through purifying, add excipient and form dissolved granule again.

2, according to the described Xinmaikang medicine of claim 1, it is characterized in that: the ratio of crude drug in whole each component (weight ratio) is: Rhizoma Gastrodiae 15-25 part, Radix Salviae Miltiorrhizae 25-35 part, Flos Carthami 1-6 part, Flos Chrysanthemi 5-15 part, Radix Saposhnikoviae 5-15 part, Radix Astragali 40-60 part, Rhizoma Chuanxiong 1-10 part, Fructus Crataegi 10-25 part, Cortex Eucommiae 5-15 part, Radix Puerariae 25-35 part, Scorpio 5-15 part, Concha Haliotidis 25-35, Rhizoma Alismatis 5-15 part, Semen Raphani 15-25.

3, according to the described Xinmaikang medicine of claim 1, it is characterized in that: the optimum formula ratio (weight ratio) of crude drug in whole each component is: 20 parts in Rhizoma Gastrodiae, 30 parts of Radix Salviae Miltiorrhizaes, 3 parts on Flos Carthami, 10 parts of Flos Chrysanthemis, 10 parts of Radix Saposhnikoviaes, 50 parts of Radix Astragali, 6 parts of Rhizoma Chuanxiongs, 15 parts of Fructus Crataegis, 10 parts of the Cortexs Eucommiae, 30 parts of Radix Puerariaes, 10 parts of Scorpio, 30 parts of Concha Haliotidis, 10 parts of Rhizoma Alismatis, 20 parts of Semen Raphanis.