CN1135106C - Naomaisu medicine - Google Patents

Abstract

The present invention discloses a Naomaisu traditional Chinese medicine granular preparation which is the granular preparation prepared from traditional Chinese medicine such as tall gastrodis tuber, raw stilbene, chuanxiong rhizome, double hook, nacre, scorpion, leech, panax notoginseng, kudzuvine root, cassia occidentalis semen cassiae torae, ledebouriella root, radix achyranthis bidentatae, red sage root, chrysanthemum, earthworm, stiff silkorm, bile arisaema, grassleaf sweetflag rhizome, white atractylodes rhizome, rhizoma dioscorear from Henan of China, eucommia bark, etc., through the process steps of heating, decoction, concentration, evaporation for removing water, baking, etc. The traditional Chinese medicine granular preparation is mainly used for treating cerebral apoplexy in an acute stage, a recovery stage and a sequelae stage. The traditional Chinese medicine granular preparation can accelerate the regression and the absorption of hemorrhagic cerebral apoplexy so as to regress and absorb the thrombus of ischemia cerebral apoplexy. The traditional Chinese medicine granular preparation not only can strengthen the spleen and the stomach, benefit qi and absorb clots, but also can benefit and restore vital energy without the obstacle of clotted stasis as well as activate blood circulation for dispelling stasis without overflow.

Description

A kind of Chinese medicine for the treatment of the apoplexy disease and preparation method thereof

Affiliated technical field

The present invention relates to a kind of Chinese medicine, particularly a kind of Chinese medicine for the treatment of apoplexy and preparation method thereof that can be used for.

Background technology

At present, the document and the medicine of domestic existing treatment apoplexy and hemiplegia, " collateral dredging blood activating decoction treatment cerebral infarction 50 examples " that Wang Fu writes have been published as " the Shaanxi traditional Chinese medical science " 1998.14, Chinese medicine preparations such as the employing Radix Astragali, Radix Codonopsis, Radix Achyranthis Bidentatae have been introduced, be used for logical whole invigorating blood circulation, treat 50 routine Cerebral Infarction Patients and show that it has certain curative effect; " three red mixture are prevented apoplexy " that " Chinese medicine research " 1997-13 (5) 35-36 publication Zhang Yiqin writes introduced a kind of to be the Chinese medicine preparation of basic composition by Radix Notoginseng, Radix Salviae Miltiorrhizae, to be used for prevention of stroke; Its Chinese medicine such as network are glad logical etc., but its therapeutic effect has certain limitation.

Summary of the invention

The object of the present invention is to provide a kind of acute stage, convalescent period and sequela stage that can be used for treating apoplectic hemiplegia, the absorption of disappearing of the hematoma that can accelerate hemorrhagic cerebral apoplexy makes Chinese medicine of the treatment apoplexy disease that the thrombosis of ischemia apoplexy disappears molten and preparation method thereof.

The object of the present invention is achieved like this.With Rhizoma Gastrodiae, Scorpio, Arisaema Cum Bile, Rhizoma Acori Graminei, Radix Puerariae, Radix Saposhnikoviae, Concha Margaritifera, Radix Achyranthis Bidentatae is monarch drug, in order to suppressing the hyperactive liver to relieve the wind syndrome, the refreshment of eliminating phlegm for resuscitation; With Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, the Cortex Eucommiae, Ramulus Uncariae macrophyllae, Hirudo, Radix Notoginseng, Lumbricus, Bombyx Batryticatus, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Flos Chrysanthemi, Radix Astragali, Semen Cassiae is ministerial drug, in order to benefiting qi and removing blood stasis, the collateral dredging that eliminates the phlegm, nourishing the liver and kidney, thereby reaches the purpose of first refreshing reversion; Each component ratio (weight ratio) is: Rhizoma Gastrodiae 15-25 part, Radix Astragali 30-50 part, Rhizoma Chuanxiong 1-6 part, Ramulus Uncariae macrophyllae 5-15 part, Concha Margaritifera 20-40 part, Scorpio 5-15 part, Hirudo 15-25 part, Radix Notoginseng 10-20 part, Radix Puerariae 15-25 part, Semen Cassiae 5-15 part, Radix Saposhnikoviae 5-15 part, Radix Achyranthis Bidentatae 10-20 part, Radix Salviae Miltiorrhizae 25-35 part, Flos Chrysanthemi 10-20 part, Lumbricus 5-15 part, Bombyx Batryticatus 5-15 part, Arisaema Cum Bile 1-10 part, Rhizoma Acori Graminei 5-15 part, Rhizoma Atractylodis Macrocephalae 5-15 part, Rhizoma Dioscoreae 25-35 part, Cortex Eucommiae 5-15 part.The optimum formula ratio (weight ratio) of crude drug in whole each component is: 20 parts in Rhizoma Gastrodiae, 40 parts of Radix Astragali, 3 parts of Rhizoma Chuanxiongs, 10 parts of Ramulus Uncariae macrophyllaes, 30 parts of Concha Margaritiferas, 10 parts of Scorpios, 20 parts of Hirudos, 15 parts of Radix Notoginseng, 20 parts of Radix Puerariaes, 10 parts of Semen Cassiaes, 10 parts of Radix Saposhnikoviaes, 15 parts of Radix Achyranthis Bidentataes, 30 parts of Radix Salviae Miltiorrhizaes, 15 parts of Flos Chrysanthemis, 10 parts of Lumbricuss, 10 parts of Bombyx Batryticatus, 6 parts of Arisaema Cum Bile, 10 parts of Pus of stone battalion, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 30 parts of Rhizoma Dioscoreaes, 10 parts of the Cortexs Eucommiae.

Its preparation method is: at first by the processing concocted specification crude drug in whole is carried out preliminary working; Second step was that crude drug in whole and decoction pieces that processing cooks are dropped into multi-function extractor, the water that adds 4-8 times of drug weight heats and decocts, and boiling back slow fire boils 40 minutes to 2 hours after-filtration for the first time, add for the second time the water of 2-6 times of drug weight, simmered in water after boiling 30-60 minute; The 3rd step dropped into vacuum concentrator with twice filtered medicine liquid and concentrates, drop into again after concentrating and carry out water evaporates in the jacketed pan and become the glue sap-shape, take out again and put into the thermal cycle drying baker, the heated drying temperature is controlled between 50-65 ℃, took out in the about 5-9 of heated drying hour absolutely dry glue sheet medicine, through purifying, add excipient and form dissolved granule patent medicine again.

Advantage of the present invention is: decoct, concentrate, evaporate and anhydrate, make after the operation such as drying and purification by natural Chinese medicines is added to heat behind the water by formula proportion, also can be made into dissolved granule.It can be used for treating acute stage, convalescent period and the sequela stage of apoplexy, the absorption of disappearing of the hematoma that can accelerate hemorrhagic cerebral apoplexy, it is molten that the thrombosis of ischemia apoplexy is disappeared, can not only invigorating the spleen and regulating the stomach, QI invigorating reduces phlegm, and can reversion vigour and do not have and stop up hindering of stagnating, blood circulation promoting and blood stasis dispelling and do not have excessive fraud.

Chinese medicine and modern Chinese medicine are all thought: apoplexy is deficiency of the liver and kindey, apoplexy and vertigo reciprocal causation relation, dizziness is the basis of apoplexy, in treatment dizziness and apoplexy equally from liver from kidney, take into account wind, fire, expectorant, the stasis of blood, thereby reach the suppressing the hyperactive liver to arrest the wind syndrome, the refreshment of eliminating phlegm for resuscitation, search the air slaking blood stasis and smoothing collaterals, the effect of benefiting QI and nourishing blood.The each component that the present invention has used always in having adopted the Chinese medicine prescription also utilizes its basic pharmacology, components such as the Radix Saposhnikoviae that is of little use in the prescription of diseases such as traditional Chinese medicine apoplectic hemiplegia, Radix Puerariae have also been adopted, wherein mainly be to adopt the diffusing wind of Radix Saposhnikoviae and stimulate the menstrual flow to reach network, and reduce phlegm and the same usefulness of product of blood, and play that phlegm-fire is clear, QI and blood and effect, because of stroke patient, it is few moving to crouch, and QI-blood circulation is not smooth, and normal wind total numbness, acid are expanded, the property that the utilization Radix Saposhnikoviae leads to walk among the we, his medicine relieving the exterior syndrome of band we is walked network; Adopt Radix Puerariae to be because its abnormal smells from the patient is all thin, can rise the gas of sending out the clear sun of taste, can make not reason insufficiency of vital energy and blood and withering of extremity.

The specific embodiment

Embodiment 1: with Rhizoma Gastrodiae, Scorpio, Arisaema Cum Bile, Rhizoma Acori Graminei, Radix Puerariae, Radix Saposhnikoviae, Concha Margaritifera, Radix Achyranthis Bidentatae is monarch drug, in order to suppressing the hyperactive liver to relieve the wind syndrome, the refreshment of eliminating phlegm for resuscitation; With Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, the Cortex Eucommiae, Ramulus Uncariae macrophyllae, Hirudo, Radix Notoginseng, Lumbricus, Bombyx Batryticatus, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Flos Chrysanthemi, Radix Astragali, Semen Cassiae is ministerial drug, in order to benefiting qi and removing blood stasis, the collateral dredging that eliminates the phlegm, nourishing the liver and kidney, thereby reaches the purpose of first refreshing reversion; At first the crude drug in whole each component being pressed formula proportion (weight ratio) extracts: 20 parts in Rhizoma Gastrodiae, 40 parts of Radix Astragali, 3 parts of Rhizoma Chuanxiongs, 10 parts of Ramulus Uncariae macrophyllaes, 30 parts of Concha Margaritiferas, 10 parts of Scorpios, 20 parts of Hirudos, 15 parts of Radix Notoginseng, 20 parts of Radix Puerariaes, 10 parts of Semen Cassiaes, 10 parts of Radix Saposhnikoviaes, 15 parts of Radix Achyranthis Bidentataes, 30 parts of Radix Salviae Miltiorrhizaes, 15 parts of Flos Chrysanthemis, 10 parts of Lumbricuss, 10 parts of Bombyx Batryticatus, 6 parts of Arisaema Cum Bile, 10 parts of Rhizoma Acori Graminei, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 30 parts of Rhizoma Dioscoreaes, 10 parts of the Cortexs Eucommiae, adopt Hunan Province's concocted specification that each component is carried out preliminary working; Crude drug in whole that processing is cooked and decoction pieces drop into multi-function extractor then, the water that adds 6 times of drug weight heats and decocts, and the back slow fire that boils for the first time boils 60 minutes after-filtration, add for the second time the water of 4 times of drug weight, 40 minutes after-filtration simmer in water after boiling; After again twice filtering liquid medicine input vacuum concentrator being concentrated, take out to drop into again and carry out water evaporates in the jacketed pan and become the glue sap-shape, put into the thermal cycle drying baker again, dry the temperature inside the box is controlled between 50-65 ℃, take out after dry about 6 hours, absolutely dry glue sheet medicine, purify through conventional medicine purifying technique again, add excipient and form dissolved granule patent medicine.

Embodiment 2, and the film patent medicine that the formula proportion of embodiment 1 is made is used for clinical experiment, as Liu male patient at 66 years old, because of left limb moving obstacle 3 days, look into BP:160/90mmHg, staring spells is hindered, spirit is poor, apathetic expression, bradykinesia, the memory ability of thinking is poor, the big circle that waits such as double vision, and light reflex is blunt, two nasolabial fold symmetries, lip is acomia, and it is placed in the middle to loll, two pulmonary respiration sounds are clear, heart rate HR:83 time/minute, and rule is neat, sound can, abdominal part is grand soft, no tenderness and rebound tenderness, liver, spleen do not lay one's hand on and, left upper extremity muscular strength I level, grip disappears, 0 grade of left lower extremity muscular strength, muscular tension is low, left knee jerk (+), babinski sign (+); Medical history: previously hypertension is arranged 8 years, diabetic history 5 years; Experimental data: Hb:140g/L, wBc:5.2 * 10 ⁹/ l, N:0.6, L:0.4, PT:110 * 10 ⁹/ l, B.S:16.5mmol/l; Three of blood fat are: TG:2.26, TCH:6.46, HDL:1.61; ECG shows sinus rhythm, and the T ripple changes, the slight left avertence of electric axis, and CT shows: cerebral infarction.Tcm diagnosis is: the apoplexy apoplex involving the channels and collaterals; Western medicine diagnose is: cerebral infarction, essential hypertension, diabetes, coronary heart disease, hyperlipemia.At this disease, every day is to patient's electuary secondary of the present invention of taking after mixing it with water, each 25 grams, treat after 59 days, the patient feels that disease disappears substantially, and the state of an illness is almost recovered, blood pressure maintains about 130/80mmHg, HR:75 time/minute, rule is neat, and sound can, ECG shows that electrocardiogram is roughly normal, three checks of blood fat are: TG:1.539, TCH:5.17, HDL:1.54; B.S:5.4mmol/l, left upper extremity muscular strength V level, grip is normal, left lower extremity muscular strength V level, muscular tension is normal, left knee jerk (-), gram. cloth. babinski sign (-).Clinical control during according to present embodiment patient admission and discharge, the present invention is to apoplexy, cerebral infarction, essential hypertension, diabetes, coronary heart disease, and diseases such as hyperlipemia have significant curative effect.

Embodiment 3, and the film patent medicine that the formula proportion of embodiment 1 is made is used for clinical experiment, as at male patient Europe of 74 years old, because of speech owes sharp, the right side hemiplegia is surplus January, looks into BP:145/99mmHg, and is refreshing clear, spirit is poor, look asthenia, bradykinesia, the memory ability of thinking is poor, the big circle that waits such as double vision, and light reflex is blunt, bicker is crooked slightly to the right, and the left side nasolabial fold shoals slightly, and it is placed in the middle to loll, neck is soft, the passivity sense, and two pulmonary respiration sounds are clear, heart rate HR:56 time/minute, rule is neat, no pathologic noise, abdomen is flat soft, no tenderness and rebound tenderness, liver, spleen do not throw away and, two kidneys district does not have percussion pain, and borborygmus is normal, 0 grade of right upper extremity muscular strength, grip disappears, right lower extremity muscular strength II level, muscular tension height, feel to go down in the right side, far-end more so, the right side quadriceps reflex is hyperfunction, crust. gram. brudzinski's sign feminine gender, red tongue with thin and yellow fur, deep and stringy pulse; Hypertension history is previously arranged; Experimental data: Hb:130g/l, wBc:5.0 * 10 ⁹/ l, N:0.6, L:0.4, PT:200 * 10 ⁹/ l, B.S:4.9mmol/l; Three of blood fat are: TG:1.738, TCH:3.98, HDL:1.35; ECG shows sinus bradycardia; CT shows: left side capsula interna district cerebral hemorrhage.Tcm diagnosis is: apoplexy, dizzy; Western medicine diagnose is: cerebral hemorrhage (convalescent period), hypertension III phase, cerebral arteriosclerosis.At this disease, every day is to patient's electuary secondary of the present invention of taking after mixing it with water, each 25 grams, hospitalization 48 days, the patient feels that disease disappears substantially, and the state of an illness is almost recovered, and blood pressure maintains about 120/80mmHg, and spirit is good, speech is fluent, and thinking, respond improve two nasolabial fold symmetries, HR:70 time/minute, rule is neat, and sound can, right upper extremity muscular strength IV level, right lower extremity muscular strength V level, grip is normal, muscular tension is normal, and the right side is quick of perception, the knee jerk feminine gender.Clinical control during according to present embodiment patient admission and discharge, the present invention has significant curative effect to diseases such as apoplexy, dizzy, cerebral hemorrhage (convalescent period), hypertension III phase, cerebral arteriosclerosis.

At the patient of symptoms such as hemiplegia, apoplexy, dizzy, cerebral infarction, essential hypertension, cerebral hemorrhage (convalescent period), hypertension III phase, cerebral arteriosclerosis, every day is to patient's electuary secondary of the present invention of taking after mixing it with water.Each 25 the gram, 30 days is a course of treatment, take three courses of treatment altogether after, all pathological changes symptoms all can disappear or alleviate; By to the clinical observation of 1746 examples nearly, effective percentage reaches 98%.

Claims (3)

1, a kind of Chinese medicine for the treatment of the apoplexy disease is characterized in that what it was made up of the material medicine water extract of following weight ratio: Rhizoma Gastrodiae 15-25 part, Radix Astragali 30-50 part, Rhizoma Chuanxiong 1-6 part, Ramulus Uncariae macrophyllae 5-15 part, Concha Margaritifera 20-40 part, Scorpio 5-15 part, Hirudo 15-25 part, Radix Notoginseng 10-20 part, Radix Puerariae 15-25 part, Semen Cassiae 5-15 part, Radix Saposhnikoviae 5-15 part, Radix Achyranthis Bidentatae 10-20 part, Radix Salviae Miltiorrhizae 25-35 part, Flos Chrysanthemi 10-20 part, Lumbricus 5-15 part, Bombyx Batryticatus 5-15 part, Arisaema Cum Bile 1-10 part, Rhizoma Acori Graminei 5-15 part, Rhizoma Atractylodis Macrocephalae 5-15 part, Rhizoma Dioscoreae 25-35 part, Cortex Eucommiae 5-15 part.

2, according to the Chinese medicine of the described treatment apoplexy of claim 1 disease, it is characterized in that: the optimum formula ratio (weight ratio) of crude drug in whole each component is: 20 parts in Rhizoma Gastrodiae, 40 parts of Radix Astragali, 3 parts of Rhizoma Chuanxiongs, 10 parts of Ramulus Uncariae macrophyllaes, 30 parts of Concha Margaritiferas, 10 parts of Scorpios, 20 parts of Hirudos, 15 parts of Radix Notoginseng, 20 parts of Radix Puerariaes, 10 parts of Semen Cassiaes, 10 parts of Radix Saposhnikoviaes, 15 parts of Radix Achyranthis Bidentataes, 30 parts of Radix Salviae Miltiorrhizaes, 15 parts of Flos Chrysanthemis, 10 parts of Lumbricuss, 10 parts of Bombyx Batryticatus, 6 parts of Arisaema Cum Bile, 10 parts of Rhizoma Acori Graminei, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 30 parts of Rhizoma Dioscoreaes, 10 parts of the Cortexs Eucommiae.

3, the preparation method of Chinese medicine of the described treatment apoplexy of claim 1 disease, it is characterized in that: at first crude drug in whole is carried out preliminary working by the processing concocted specification, second step was that crude drug in whole and decoction pieces that processing cooks are dropped into multi-function extractor, the water that adds 4-8 times of drug weight, heat and decoct, boiling back slow fire boils 40 minutes to 2 hours after-filtration for the first time, adds the water of 2-6 times of drug weight for the second time, simmers in water after boiling 30-60 minute; The 3rd step dropped into vacuum concentrator with twice filtered medicine liquid and concentrates, drop into again after concentrating and carry out water evaporates in the jacketed pan and become the glue sap-shape, take out again and put into the thermal cycle drying baker, the heated drying temperature is controlled between 50-65 ℃, took out in the about 5-9 of heated drying hour absolutely dry glue sheet medicine, through purifying, add excipient and form dissolved granule patent medicine again.