CN105535186A - Preparation method of heart and spleen tonifying decoction for treating rheumatic heart diseases - Google Patents

Preparation method of heart and spleen tonifying decoction for treating rheumatic heart diseases Download PDF

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CN105535186A
CN105535186A CN201610075481.1A CN201610075481A CN105535186A CN 105535186 A CN105535186 A CN 105535186A CN 201610075481 A CN201610075481 A CN 201610075481A CN 105535186 A CN105535186 A CN 105535186A
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radix
parts
heart
preparation
spleen
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K36/704—Polygonum, e.g. knotweed
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
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    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention discloses a preparation method of a heart and spleen tonifying decoction for treating rheumatic heart diseases. The decoction is mainly prepared from the following active pharmaceutical ingredients in parts by weight: 20-40 parts of radix astragali, 6-12 parts of herb of rosemary, 6-18 parts of radix codonopsis, 8-16 parts of morinda root, 6-12 parts of Jian medicated leaven, 10-15 parts of largehead atractylodes rhizome, 9-12 parts of Chinese angelica, 10-15 parts of rose mallow root, 6-10 parts of liquorice root (fried), 5-12 parts of root of Hongkong caper, 8-14 parts of Indian bread with pine, 4-9 parts of thinleaf milkwort root-bark, 8-12 parts of costustoot, 6-13 parts of cassia twig, 6-9 parts of cynanchoides polygonum, 5-10 parts of cape jasmine fruit and 3-6 parts of officinal magnolia bark. The heart and spleen tonifying preparation for treating rheumatic heart diseases, which is provided by the invention, is scientific in formula, is simple in preparation method, is convenient to use and has the functions of tonifying the heart and the spleen and nourishing blood and engendering liquid aiming at the rheumatic heart diseases.

Description

The preparation method of rheumatic heart disease invigorating the heart and spleen preparation decoction
Divisional application, original applying number 2014106105098, applying date 2014.11.04, title rheumatic heart disease invigorating the heart and spleen preparation and preparation method.
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of rheumatic heart disease invigorating the heart and spleen preparation and preparation method.
Background technology
Rheumatic heart disease is called for short rheumatic heart disease, refers to due to rheumatic fever activity, involves cardiac valve and the valve disorder that causes.Cash as having one or several valvular stenosis and incompetence in Bicuspid valve, Tricuspid valve, initiatively valve.Its cause of disease is that first group beta hemolytic streptococcus infects the allergic part performance caused, and belongs to autoimmune disease.The pathological change of cardia mainly occurs in cardiac valve position.Bicuspid valve is the most common affected area.Due to valvular pathological changes, heart is gone wrong when transporting blood, resistance of blood flow is strengthened, in order to penetrate enough blood, heart is diastole and contraction more arduously then, makes heart working intensity strengthen like this, efficiency reduces, and heart fatiguability, causes cardiac hypertrophy in the course of time.As mitral stenosis to a certain extent time increasing due to left atrial pressure, cause pulmonary vein and pulmonary capillary pressure to increase, formed pulmonary venous pleonaemia, easily cause following symptom after pulmonary venous pleonaemia: 1. dyspnea; 2. cough; 3. hemoptysis, what have also there will be hoarseness and dysphagia.
Publication No. CN102973888A(application number 201210468831.2) Chinese patent literature disclose a kind of pill and preparation method for the treatment of rheumatic heart disease, the raw material composition of effective ingredient and parts by weight are: Ramulus Cinnamomi 50 ~ 70 parts, Radix Glycyrrhizae Preparata 50 ~ 65 parts, Radix Ophiopogonis 45 ~ 60 parts, Fructus Schisandrae Chinensis 45 ~ 60 parts, 40 ~ 55 parts, Poria, Radix Astragali Preparata 40 ~ 50 parts, Radix Curcumae 40 ~ 50 parts, Radix Ilicis Pubescentis 35 ~ 45 parts, Radix Salviae Miltiorrhizae 35 ~ 45 parts, Semen Platycladi 30 ~ 40 parts, Fructus Trichosanthis 25 ~ 40 parts, Arillus Longan 20 ~ 30 parts, Rhizoma Chuanxiong 20 ~ 30 parts, Radix Polygalae (parched) 15 ~ 30 parts, Rhizoma Acori Graminei 15 ~ 25 parts, Jambul core 10 ~ 25 parts.Publication No. CN103191402A(application number 201310155159.6) Chinese patent literature disclose a kind of medicine for the treatment of rheumatic heart disease and preparation method thereof, it is mainly prepared from according to a certain weight ratio by Flos Celosiae Cristatae, the Radix Astragali, Radix Camelliae sinensis, Rhizoma Polygonati Odorati, Folium pyri, Semen Persicae, Lignum Pini Nodi and Radix Cyathulae.Publication No. CN103110877A(application number 201210529231.2) Chinese patent literature disclose a kind of Chinese medicine preparation for the treatment of rheumatic heart disease, the weight of each raw material of Chinese medicine consists of: the Radix Astragali 5 parts, Radix Ginseng 2 parts, 4 parts, Poria, Radix Salviae Miltiorrhizae 4 parts, Radix Notoginseng 1 part, Fructus Schisandrae Chinensis 3 parts, Rhizoma Acori Graminei 3 parts, 3 parts, Semen Persicae, Radix Curcumae 3 parts and Herba Lycopi 3 parts.
Current western medical treatment, adopts operative treatment usually, not only spends huge, postoperative patient physical weakness, less effective, so people have great demand for this symptom for the treatment of by Chinese herbs.
Summary of the invention
For the problem of prior art, the object of this invention is to provide a kind of Be very effective, take the invigorating the heart and spleen preparation of the treatment rheumatic heart disease that safety has no side effect.
Technical scheme of the present invention is:
Rheumatic heart disease invigorating the heart and spleen preparation, is prepared from primarily of following bulk drugs, is weight portion: Radix Astragali 20-40; Herba Rosmarini Officinalis 6-12; Radix Codonopsis 6-18; Radix Morindae Officinalis 8-16; Massa Medicata Fermentata 6-12; Rhizoma Atractylodis Macrocephalae 10-15; Radix Angelicae Sinensis 9-12; Radix Urenae Lobatae 10-15; Radix Glycyrrhizae (processing) 6-10; Radix Capparis Membranaceae 5-12; Poria cum Radix Pini 8-14; Radix Polygalae 4-9; Radix Aucklandiae 8-12; Ramulus Cinnamomi 6-13; Polygonum cynanchoides Hemsl. 6-9; Rhizoma Zingiberis Recens Fructus Gardeniae 5-10; Purple Cortex Magnoliae Officinalis 3-6.
Preferred version is; Radix Astragali 25-35; Herba Rosmarini Officinalis 8-10; Radix Codonopsis 10-14; Radix Morindae Officinalis 10-14; Massa Medicata Fermentata 8-10; Rhizoma Atractylodis Macrocephalae 11-14; Radix Angelicae Sinensis 10-11; Radix Urenae Lobatae 11-14; Radix Glycyrrhizae (processing) 7-9; Radix Capparis Membranaceae 7-10; Poria cum Radix Pini 10-12; Radix Polygalae 5-8; Radix Aucklandiae 9-11; Ramulus Cinnamomi 8-11; Polygonum cynanchoides Hemsl. 7-8; Rhizoma Zingiberis Recens Fructus Gardeniae 6-9; Purple Cortex Magnoliae Officinalis 4-5.
What be more preferably is: the Radix Astragali 30; Herba Rosmarini Officinalis 9; Radix Codonopsis 12; Radix Morindae Officinalis 12; Massa Medicata Fermentata 9; The Rhizoma Atractylodis Macrocephalae 12.5; Radix Angelicae Sinensis 10.5; Radix Urenae Lobatae 12.5; Radix Glycyrrhizae (processing) 8; Radix Capparis Membranaceae 8.5; Poria cum Radix Pini 11; Radix Polygalae 6.5; The Radix Aucklandiae 10; Ramulus Cinnamomi 9.5; Polygonum cynanchoides Hemsl. 7.5; Rhizoma Zingiberis Recens Fructus Gardeniae 7.5; Purple Cortex Magnoliae Officinalis 4.5.
The invention provides and this invigorating the heart and spleen preparation is made pharmaceutically acceptable decoction, powder, capsule and thick paste agent.
The preparation method of described decoction is:
(1) getting Mel is placed in pot, is heated to boiling, put into Herba Rosmarini Officinalis, Radix Urenae Lobatae, Ramulus Cinnamomi, Radix Glycyrrhizae, with slow fire heating, fry to micro-yellow, drying with tack-free is standard, and taking-up cools;
(2) get the Radix Astragali, Radix Codonopsis, Radix Morindae Officinalis, the Rhizoma Atractylodis Macrocephalae, Fructus Gardeniae clean remove impurity, be cut into fragment, add Sucus Zingberis and mix thoroughly, moist 20-30 minute (preferably 25 minutes), be placed in slow fire heating fried dry in pot, taking-up cools;
(3) Massa Medicata Fermentata, Radix Capparis Membranaceae, Poria cum Radix Pini, Polygonum cynanchoides Hemsl., purple Cortex Magnoliae Officinalis, Radix Polygalae are put into marmite, add medical material weight 5-7 water (preferably 6 times) doubly to soak 30 minutes, big fire is heated to boiling, add step (1) (2) gained medical material again, turn little fire and decoct 40-60 minute (preferably 50 minutes), filter to obtain medicinal liquid;
(4) recrement adds water and continues to decoct, and the time is 30-40 minute (preferably 35 minutes), and filtered while hot obtains medicinal liquid;
(5) get Radix Angelicae Sinensis, the rinse of Radix Aucklandiae clear water, remove impurity, put into drier, taking-up pulverizes and sieves, and mixs homogeneously with above-mentioned gained filtrate, and sterilizing encapsulation obtains Chinese medicine decoction.
The manufacture method of affiliated decoction, the order number that step (5) is sieved is 100 order-120 orders (preferably 110 orders).
The preparation method of described powder is:
(1) getting Mel is placed in pot, is heated to boiling, put into Herba Rosmarini Officinalis, Radix Urenae Lobatae, Ramulus Cinnamomi, Radix Glycyrrhizae, with slow fire heating, fry to micro-yellow, drying with tack-free is standard, and taking-up cools;
(2) get the Radix Astragali, Radix Codonopsis, Radix Morindae Officinalis, the Rhizoma Atractylodis Macrocephalae, Fructus Gardeniae clean remove impurity, be cut into fragment, add Sucus Zingberis and mix thoroughly, moist 20-30 minute (preferably 25 minutes), be placed in slow fire heating fried dry in pot, taking-up cools;
(3) Massa Medicata Fermentata, Radix Capparis Membranaceae, Poria cum Radix Pini, Polygonum cynanchoides Hemsl., purple Cortex Magnoliae Officinalis, Radix Polygalae are put into marmite, add the water soaking 30 minutes of medical material weight 5 times, big fire is heated to boiling, and little fire is inspissated slowly and is reduced to 1/4 of original volume, cools after oven dry;
(4) get Radix Angelicae Sinensis, Radix Aucklandiae rinse, remove impurity, after putting into drier, mix with above-mentioned steps (1) (2) (3) gained medical material, pulverized 100 mesh sieves, Packs sterilized dresses up Chinese medicine powder.
The preparation method of described capsule is:
(1) getting Mel is placed in pot, is heated to boiling, put into Herba Rosmarini Officinalis, Radix Urenae Lobatae, Ramulus Cinnamomi, Radix Glycyrrhizae, with slow fire heating, fry to micro-yellow, drying with tack-free is standard, and taking-up cools;
(2) get the Radix Astragali, Radix Codonopsis, Radix Morindae Officinalis, the Rhizoma Atractylodis Macrocephalae, Fructus Gardeniae clean remove impurity, be cut into fragment, add Sucus Zingberis and mix thoroughly, moist 20-30 minute (preferably 25 minutes), be placed in slow fire heating fried dry in pot, taking-up cools;
(3) Massa Medicata Fermentata, Radix Capparis Membranaceae, Poria cum Radix Pini, Polygonum cynanchoides Hemsl., purple Cortex Magnoliae Officinalis, Radix Polygalae are put into marmite, add medical material weight 5-7 water (preferably 6 times) doubly to soak 30 minutes, big fire is heated to boiling, add step (1) (2) gained medical material again, turn little fire and decoct 40-60 minute (preferably 50 minutes), filter to obtain medicinal liquid;
(4) get Radix Angelicae Sinensis, Radix Aucklandiae rinse, remove impurity, after putting into drier, pulverized 100 mesh sieves, mix homogeneously with step (3) gained medicinal liquid, after concentrate drying, be ground into end, make Chinese medicine capsules according to 0.5g/ grain.
The preparation method of described thick paste agent is:
(1) getting Mel is placed in pot, is heated to boiling, put into Herba Rosmarini Officinalis, Radix Urenae Lobatae, Ramulus Cinnamomi, Radix Glycyrrhizae, with slow fire heating, fry to micro-yellow, drying with tack-free is standard, and taking-up cools;
(2) get the Radix Astragali, Radix Codonopsis, Radix Morindae Officinalis, the Rhizoma Atractylodis Macrocephalae, Fructus Gardeniae clean remove impurity, be cut into fragment, add Sucus Zingberis and mix thoroughly, moist 20-30 minute (preferably 25 minutes), be placed in slow fire heating fried dry in pot, taking-up cools;
(3) Massa Medicata Fermentata, Radix Capparis Membranaceae, Poria cum Radix Pini, Polygonum cynanchoides Hemsl., purple Cortex Magnoliae Officinalis, Radix Polygalae are put into marmite, add medical material weight 5-7 water (preferably 6 times) doubly to soak 30 minutes, big fire is heated to boiling, add step (1) (2) gained medical material again, turn little fire and decoct 40-60 minute (preferably 50 minutes), filter to obtain medicinal liquid;
(4) get Radix Angelicae Sinensis, the rinse of Radix Aucklandiae clear water, remove impurity, pulverized 100 mesh sieves, and mix with step (3) gained medicinal liquid together with step (1) (2) gained medical material, heating is concentrated into the thick paste of relative density 1.24, obtains traditional Chinese medicine thick paste agent.
Present invention also offers the application of described rheumatic heart disease invigorating the heart and spleen preparation when preparing the medicine for the treatment of rheumatic heart disease.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
The Radix Astragali: property is sweet, tepor.Return lung, spleen, liver, kidney channel.There is effect that benefiting QI for strengthening the superficies, arresting sweating are admittedly de-, hold in the palm skin ulcer granulation promoting, inducing diuresis to remove edema.Be generally used for the treatment deficiency of vital energy weak, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.
Herba Rosmarini Officinalis: base is former: be the herb of Labiatae Rosmarinus plant rosemary.Composition: book on Chinese herbal medicine is containing flavonoid: Hesperidin, diosmin, shore Ji xanthosine etc.Alkaloid: rosmarinine, isorosmaricine.Triterpenes: ursolic acid, rosmarinic acid etc.The property of medicine: supplement to the Herbal: " pungent, temperature, nontoxic." function cures mainly: diaphoresis, spleen invigorating, calms the nerves, pain relieving.Cure mainly various headache, prevent early stage alopecia.
Radix Codonopsis: nature and flavor with return through: sweet, flat.Return spleen, lung meridian.Function with cure mainly: spleen invigorating lung benefiting, nourishing blood to promote the production of body fluid.For deficiency of both the splenic and pulmonary QI, lack of appetite asthenia, cough dyspnea due to deficiency, insufficiency of vital energy and blood, shallow complexion, shortness of breath and palpitation, Tianjin wound is thirsty, and interior-heat is quenched one's thirst.
Radix Morindae Officinalis: base is former: be the dry root of Maguireothamnus speciosus Radix Morindae Officinalis.Nature and flavor with return through: sweet, pungent, tepor.Return kidney, Liver Channel.Function with cure mainly: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, cold womb is infertile, menoxenia, and few abdomen cold type of pain, rheumatic arthralgia, muscles and bones flaccidity is soft.
Massa Medicata Fermentata: base is former: be made up of Herba polygoni hydropiperis, Herba Xanthii grass, Herba Artemisiae Annuae, Semen Armeniacae Amarum, Semen Phaseoli, Fructus Hordei Germinatus, Fructus Crataegi (stir-fry), Pericarpium Citri Reticulatae, Herba Pogostemonis, Rhizoma Atractylodis, Cortex Magnoliae Officinalis, Radix Vladimiriae, the Radix Angelicae Dahuricae, Semen Arecae, Fructus Aurantii (parched with bran), Folium Perillae, Herba Menthae, Fructus Setariae Germinatus, Cortex Cinnamomi, Rhizoma Cyperi, Radix Glycyrrhizae, Testa Tritici, flour.Character: be filemot rectangle block, outer surface is coarse, yellowish-brown, has white mould, section loosens, yellowish-brown; Gas delicate fragrance, mildly bitter flavor.Function cures mainly: induce sweat and in.For cold and heat headache, in dyspepsia resistance, vomiting distension.
The Rhizoma Atractylodis Macrocephalae: nature and flavor with return through: bitter, sweet, temperature.Return spleen, stomach warp.Function with cure mainly: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.
Radix Angelicae Sinensis: nature and flavor with return through sweet, acrid, warm.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, effect of loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores, dryness of the intestine constipation.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Radix Urenae Lobatae (another name Oreas martiana (Hopp. Et Hornsch.) Brid.): base is former: be Malvaceae Herba urenae procumbentis platymiscium Urena lobata Linn, with root and all herbal medicine.Meridian distribution of property and flavor: sweet, light, cool.Function cures mainly: expelling wind and activating blood circulation, clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.Root: for rheumatic arthritis, flu, malaria, enteritis, dysentery, infantile dyspepsia, leucorrhea.Herb: traumatic injury is controlled in external, fracture, venom, mastitis.
Radix Glycyrrhizae Preparata: nature and flavor: sweet is flat.GUIXIN, lung, spleen, stomach warp.There is spleen reinforcing stomach function regulating, effect of Yiqi and vein recovery.For weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse.
Radix Capparis Membranaceae: base is former: be root and the leaf of Capparidaceae Capparis Spirrosa platymiscium point leaf Capparis Spirrosa.Composition: containing alkaloid, aminoacid, organic acid etc.The property of medicine: bitter, puckery, tepor, mild toxicity.Function cures mainly: promoting blood circulation to remove blood stasis, wind-expelling pain-stopping.Cure mainly traumatic injury congestive edema, amenorrhea, rheumatic arthralgia, laryngopharynx swelling and pain, toothache, stomachache.
Poria cum Radix Pini: base is former: for Polyporaceae crouches the sclerotium of hole platymiscium Poria, original kind is rudimentary plant, is the fungus colonized on pinaster.Nature and flavor with return through: sweet light, flat.Enter the heart, spleen channel; There is mind calming, calm the nerves, effect of diuretic.Cure mainly palpitation with fear of having a guilty conscience, forgetful, insomnia, infantile convulsion, dysuria.
Radix Polygalae: base is former: be the dry root of milk wort Radix Polygalae or ovum leaf Radix Polygalae.Nature and flavor with return through: bitter, pungent, temperature.GUIXIN, kidney, lung meridian.Function with cure mainly: Fructus Alpiniae Oxyphyllae of calming the nerves, restoring normal coordination between the heart and kidney, eliminates the phlegm, detumescence.The insomnia and dreamful sleep caused for disarmony between the heart and kidney, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.
The Radix Aucklandiae: nature and flavor with return through: pungent, bitter, temperature.Return spleen, stomach, large intestine, three burnt, gallbladder meridians.Function with cure mainly: promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.For the breast side of body, abdominal distention, heavy after dysentery, food stagnation does not disappear, anorexia.The real intestinal antidiarrheal of Radix Aucklandiae (roasted).For stomachache of having loose bowels.
Ramulus Cinnamomi: nature and flavor with return through acrid, sweet, warm.GUIXIN, lung, urinary bladder channel.Function with cure mainly: diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
Polygonum cynanchoides Hemsl.: base is former: be the root of Polygonaceae arsesmart cynanchum auriculatum Royle ex Wight knotweed.The property of medicine: sour, pungent, cool.Attach to the lung and stomach meridians.Function cures mainly: astringing lung-QI and relieving cough, circulation of qi promoting, removing dampness.Cure mainly pulmonary tuberculosis cough, sputum mixed with blood, pertussis, epigastric distension and distress pain, rheumatic arthralgia, the erosion of vulva does not close up for a long time.
Rhizoma Zingiberis Recens Fructus Gardeniae: Fructus Gardeniae: bitter in the mouth, cold in nature.Have pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, effect of removing pathogenic heat from blood and toxic substance from the body, vexed for calentura, heat in blood tells nosebleed, conjunctival congestion and swelling pain.Rhizoma Zingiberis Recens Fructus Gardeniae: get Fructus Gardeniae fragment, mix thoroughly with Sucus Zingberis, run through, put in pot, heat fried dry with slow fire, taking-up cools.
Purple Cortex Magnoliae Officinalis: base is former: the dry dried bark of Magnoliacea plant Cortex Magnoliae Officinalis or magnolia officinalis rehd.et wils.var.biloba rehd.et wils., root bark and branch skin.Nature and flavor with return through: bitter, pungent, temperature.Return spleen, stomach, lung, large intestine channel.Function with cure mainly: dampness expectorant, the therapeutic method to keep the adverse QI flowing downwards is except full.For humidity hysteresis damaging the spleen and stomach, gastral cavity painful abdominal mass is vomited and diarrhoea, and stagnation of QI due to dyspepsia, abdominal distention constipation, phlegm retention is breathed with cough.
Rheumatic heart disease invigorating the heart and spleen pharmaceutical formulation science provided by the invention, preparation method is simple, easy to use.In addition, its excellent part also shows:
1, the present invention is by differential diagnosis in tcm therapy, can reinforcing the heart strengthening the spleen, nourishing blood to promote the production of body fluid, Be very effective;
2, each dosage form meets theory of Chinese medical science, can play the curative effect of medicine to greatest extent;
3, the present invention can improve body immunity, contributes to improving patient body quality.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
Embodiment 1 rheumatic heart disease invigorating the heart and spleen preparation, is prepared from primarily of following bulk drugs: Radix Astragali 20g, Herba Rosmarini Officinalis 6g, Radix Codonopsis 6g, Radix Morindae Officinalis 8g, Massa Medicata Fermentata 6g, Rhizoma Atractylodis Macrocephalae 10g, Radix Angelicae Sinensis 9g, Radix Urenae Lobatae 10g, Radix Glycyrrhizae (processing) 6g, Radix Capparis Membranaceae 5g, Poria cum Radix Pini 8g, Radix Polygalae 4g, Radix Aucklandiae 8g, Ramulus Cinnamomi 6g, Polygonum cynanchoides Hemsl. 6g, Rhizoma Zingiberis Recens Fructus Gardeniae 5g, purple Cortex Magnoliae Officinalis 3g.The preparation method of above-mentioned rheumatic heart disease invigorating the heart and spleen preparation decoction is:
(1) getting Mel is placed in pot, is heated to boiling, put into Herba Rosmarini Officinalis, Radix Urenae Lobatae, Ramulus Cinnamomi, Radix Glycyrrhizae, with slow fire heating, fry to micro-yellow, drying with tack-free is standard, and taking-up cools;
(2) get the Radix Astragali, Radix Codonopsis, Radix Morindae Officinalis, the Rhizoma Atractylodis Macrocephalae, Fructus Gardeniae clean remove impurity, be cut into fragment, add Sucus Zingberis and mix thoroughly, moist 25 minutes, be placed in slow fire heating fried dry in pot, taking-up cools;
(3) Massa Medicata Fermentata, Radix Capparis Membranaceae, Poria cum Radix Pini, Polygonum cynanchoides Hemsl., purple Cortex Magnoliae Officinalis, Radix Polygalae are put into marmite, add the water soaking 30 minutes of medical material weight 5 times, big fire is heated to boiling, then adds step (1) (2) gained medical material, turn little fire to decoct 40 minutes, filter to obtain medicinal liquid;
(4) recrement adds water and continues to decoct, and the time is 30 minutes, and filtered while hot obtains medicinal liquid;
(5) get Radix Angelicae Sinensis, the rinse of Radix Aucklandiae clear water, remove impurity, put into drier, take out and pulverized 100 mesh sieves, mix homogeneously with above-mentioned gained filtrate, sterilizing encapsulation obtains Chinese medicine decoction.
Embodiment 2 rheumatic heart disease invigorating the heart and spleen preparation, is prepared from primarily of following bulk drugs: the Radix Astragali 40; Herba Rosmarini Officinalis 12; Radix Codonopsis 18; Radix Morindae Officinalis 16; Massa Medicata Fermentata 12; The Rhizoma Atractylodis Macrocephalae 15; Radix Angelicae Sinensis 12; Radix Urenae Lobatae 15; Radix Glycyrrhizae (processing) 10; Radix Capparis Membranaceae 12; Poria cum Radix Pini 14; Radix Polygalae 9; The Radix Aucklandiae 12; Ramulus Cinnamomi 13; Polygonum cynanchoides Hemsl. 9; Rhizoma Zingiberis Recens Fructus Gardeniae 10; Purple Cortex Magnoliae Officinalis 6g.The manufacture method of above-mentioned rheumatic heart disease invigorating the heart and spleen preparation powder is:
(1) getting Mel is placed in pot, is heated to boiling, put into Herba Rosmarini Officinalis, Radix Urenae Lobatae, Ramulus Cinnamomi, Radix Glycyrrhizae, with slow fire heating, fry to micro-yellow, drying with tack-free is standard, and taking-up cools;
(2) get the Radix Astragali, Radix Codonopsis, Radix Morindae Officinalis, the Rhizoma Atractylodis Macrocephalae, Fructus Gardeniae clean remove impurity, be cut into fragment, add Sucus Zingberis and mix thoroughly, moist 25 minutes, be placed in slow fire heating fried dry in pot, taking-up cools;
(3) Massa Medicata Fermentata, Radix Capparis Membranaceae, Poria cum Radix Pini, Polygonum cynanchoides Hemsl., purple Cortex Magnoliae Officinalis, Radix Polygalae are put into marmite, add the water soaking 30 minutes of medical material weight 5 times, big fire is heated to boiling, and little fire is inspissated slowly and is reduced to 1/4 of original volume, cools after oven dry;
(4) get Radix Angelicae Sinensis, Radix Aucklandiae rinse, remove impurity, after putting into drier, mix with above-mentioned steps (1) (2) (3) gained medical material, pulverized 100 mesh sieves, Packs sterilized dresses up Chinese medicine powder.
Instructions of taking: twice daily, a 5g/ bag, warm boiled water ten days is a course for the treatment of.
Model case: xxx, male, 51 years old.Patient obtains rheumatic heart disease 8 years, for a long time by the maintenance that has Western medicine, in nearly 1 year, occurs face edema, cough with asthma obviously increases the weight of, and Relapse rate shows effect.
Take this example gained Chinese medicine powder, after patient uses a course for the treatment of, edema, cough with asthma phenomenon alleviate, and can slightly work, and continue two courses for the treatment of of use, uncomfortable disease disappears substantially, can normally work, and to follow up a case by regular visits in 1 year the state of an illness without increasing the weight of.
Take this example gained Chinese medicine powder, after three days, patient's phenomenon of suffering from diarrhoea obviously is alleviated, continue to take two the course for the treatment of order, the uncomfortable disease of patient disappears, and physical recovery is healthy, and self-induction is fully recovered.
Embodiment 3 rheumatic heart disease invigorating the heart and spleen preparation, is prepared from primarily of following bulk drugs: Radix Astragali 25g, Herba Rosmarini Officinalis 8g, Radix Codonopsis 10g, Radix Morindae Officinalis 10g, Massa Medicata Fermentata 8g, Rhizoma Atractylodis Macrocephalae 11g, Radix Angelicae Sinensis 10g, Radix Urenae Lobatae 11g, Radix Glycyrrhizae (processing) 7g, Radix Capparis Membranaceae 7g, Poria cum Radix Pini 10g, Radix Polygalae 5g, Radix Aucklandiae 9g, Ramulus Cinnamomi 8g, Polygonum cynanchoides Hemsl. 7g, Rhizoma Zingiberis Recens Fructus Gardeniae 6g, purple Cortex Magnoliae Officinalis 4g.The manufacture method of above-mentioned rheumatic heart disease invigorating the heart and spleen preparation capsule is:
(1) getting Mel is placed in pot, is heated to boiling, put into Herba Rosmarini Officinalis, Radix Urenae Lobatae, Ramulus Cinnamomi, Radix Glycyrrhizae, with slow fire heating, fry to micro-yellow, drying with tack-free is standard, and taking-up cools;
(2) get the Radix Astragali, Radix Codonopsis, Radix Morindae Officinalis, the Rhizoma Atractylodis Macrocephalae, Fructus Gardeniae clean remove impurity, be cut into fragment, add Sucus Zingberis and mix thoroughly, moist 25 minutes, be placed in slow fire heating fried dry in pot, taking-up cools;
(3) Massa Medicata Fermentata, Radix Capparis Membranaceae, Poria cum Radix Pini, Polygonum cynanchoides Hemsl., purple Cortex Magnoliae Officinalis, Radix Polygalae are put into marmite, add the water soaking 30 minutes of medical material weight 6 times, big fire is heated to boiling, then adds step (1) (2) gained medical material, turn little fire to decoct 50 minutes, filter to obtain medicinal liquid;
(4) get Radix Angelicae Sinensis, Radix Aucklandiae rinse, remove impurity, after putting into drier, pulverized 100 mesh sieves, mix homogeneously with step (3) gained medicinal liquid, after concentrate drying, be ground into end, make Chinese medicine capsules according to 0.5g/ grain.
Instructions of taking: every day, sooner or later respectively once once two ten days was a course for the treatment of.
Model case: xxx, women, 43 years old.Main suit: dizzy weak two months, feels sick three days; History of present illness: occur cardiopalmus, the deficiency of vital energy, physically-draining, persistent period number minute when dry weight is lived in nearly half a year, can spontaneous remission.Before three days, feel sick increase the weight of, a small amount of hemoptysis; Rheumatic heart disease is diagnosed as after examination in hospital.
Take this example gained Chinese medicine capsules, after the course for the treatment of of patient, muscle power improves, dizzy cardiopalmus phenomenon disappears, and continues to strengthen a course for the treatment of, self-induction is fully recovered, and follows up a case by regular visits in half a year, does not occur malaise symptoms.
Embodiment 4 rheumatic heart disease invigorating the heart and spleen preparation, is prepared from primarily of following bulk drugs: Radix Astragali 35g, Herba Rosmarini Officinalis 10g, Radix Codonopsis 14g, Radix Morindae Officinalis 14g, Massa Medicata Fermentata 10g, Rhizoma Atractylodis Macrocephalae 14g, Radix Angelicae Sinensis 11g, Radix Urenae Lobatae 14g, Radix Glycyrrhizae (processing) 9g, Radix Capparis Membranaceae 10g, Poria cum Radix Pini 12g, Radix Polygalae 8g, Radix Aucklandiae 11g, Ramulus Cinnamomi 11g, Polygonum cynanchoides Hemsl. 8g, Rhizoma Zingiberis Recens Fructus Gardeniae 9g, purple Cortex Magnoliae Officinalis 5g.The manufacture method of above-mentioned rheumatic heart disease invigorating the heart and spleen preparation thick paste agent is:
(1) getting Mel is placed in pot, is heated to boiling, put into Herba Rosmarini Officinalis, Radix Urenae Lobatae, Ramulus Cinnamomi, Radix Glycyrrhizae, with slow fire heating, fry to micro-yellow, drying with tack-free is standard, and taking-up cools;
(2) get the Radix Astragali, Radix Codonopsis, Radix Morindae Officinalis, the Rhizoma Atractylodis Macrocephalae, Fructus Gardeniae clean remove impurity, be cut into fragment, add Sucus Zingberis and mix thoroughly, moist 25 minutes, be placed in slow fire heating fried dry in pot, taking-up cools;
(3) Massa Medicata Fermentata, Radix Capparis Membranaceae, Poria cum Radix Pini, Polygonum cynanchoides Hemsl., purple Cortex Magnoliae Officinalis, Radix Polygalae are put into marmite, add the water soaking 30 minutes of medical material weight 6 times, big fire is heated to boiling, then adds step (1) (2) gained medical material, turn little fire to decoct 50 minutes, filter to obtain medicinal liquid;
(4) get Radix Angelicae Sinensis, the rinse of Radix Aucklandiae clear water, remove impurity, pulverized 100 mesh sieves, and mix with step (3) gained medicinal liquid together with step (1) (2) gained medical material, heating is concentrated into the thick paste of relative density 1.24, obtains traditional Chinese medicine thick paste agent.
Instructions of taking: every day, sooner or later respectively once once two spoonfuls of about 15g, warm boiled water ten days was a course for the treatment of.
Model case: xxx, women, 24 years old.Medical history: the long-term cardiopalmus of patient, asthma, weak, obviously increases the weight of after fatigue, can alleviate after rest; And the slight hemoptysis of intermittent appearance, nocturnal dyspnea symptom.Be rheumatic heart disease through hospital diagnosis, two valvular stenosiss.After patient takes two courses for the treatment of of this example gained traditional Chinese medicine thick paste agent, malaise symptoms all disappears, can orthobiosis, and follow up a case by regular visits in a year and a half, symptom does not recur.
Embodiment 5 rheumatic heart disease invigorating the heart and spleen preparation, is prepared from primarily of following bulk drugs: Radix Astragali 30g, Herba Rosmarini Officinalis 9g, Radix Codonopsis 12g, Radix Morindae Officinalis 12g, Massa Medicata Fermentata 9g, Rhizoma Atractylodis Macrocephalae 12.5g, Radix Angelicae Sinensis 10.5g, Radix Urenae Lobatae 12.5g, Radix Glycyrrhizae (processing) 8g, Radix Capparis Membranaceae 8.5g, Poria cum Radix Pini 11g, Radix Polygalae 6.5g, Radix Aucklandiae 10g, Ramulus Cinnamomi 9.5g, Polygonum cynanchoides Hemsl. 7.5g, Rhizoma Zingiberis Recens Fructus Gardeniae 7.5g, purple Cortex Magnoliae Officinalis 4.5g.The manufacture method of above-mentioned rheumatic heart disease invigorating the heart and spleen preparation decoction is:
(1) getting Mel is placed in pot, is heated to boiling, put into Herba Rosmarini Officinalis, Radix Urenae Lobatae, Ramulus Cinnamomi, Radix Glycyrrhizae, with slow fire heating, fry to micro-yellow, drying with tack-free is standard, and taking-up cools;
(2) get the Radix Astragali, Radix Codonopsis, Radix Morindae Officinalis, the Rhizoma Atractylodis Macrocephalae, Fructus Gardeniae clean remove impurity, be cut into fragment, add Sucus Zingberis and mix thoroughly, moist 25 minutes, be placed in slow fire heating fried dry in pot, taking-up cools;
(3) Massa Medicata Fermentata, Radix Capparis Membranaceae, Poria cum Radix Pini, Polygonum cynanchoides Hemsl., purple Cortex Magnoliae Officinalis, Radix Polygalae are put into marmite, add the water soaking 30 minutes of medical material weight 6 times, big fire is heated to boiling, then adds step (1) (2) gained medical material, turn little fire to decoct 50 minutes, filter to obtain medicinal liquid;
(4) recrement adds water and continues to decoct, and the time is 35 minutes, and filtered while hot obtains medicinal liquid;
(5) get Radix Angelicae Sinensis, the rinse of Radix Aucklandiae clear water, remove impurity, put into drier, take out and pulverized 110 mesh sieves, mix homogeneously with above-mentioned gained filtrate, sterilizing encapsulation obtains Chinese medicine decoction.
Instructions of taking: every day, sooner or later respectively once a 100-150ml ten days was a course for the treatment of.
The clinical practice of test example 1 embodiment 5 gained rheumatic heart disease invigorating the heart and spleen preparation decoction: according to hospital outpatient case history, screening Patients With Rheumatic Valvular Disease 246 example, wherein women 136 example, male 110 example, oldest 70 years old, minimum 18 years old, 40.6 years old mean age.Before test, Continuous Observation is carried out to this crowd, record symptom and change.
Curative effect determinate standard: effective: clinical symptoms is eliminated, the normal live and work of energy; Effective: cardinal symptom obviously alleviates, life and ability to work make moderate progress; Invalid: malaise symptoms is front without obviously changing with treatment.Total effective rate=obvious effective rate+effective percentage.
Test method: patient takes example five gained rheumatic heart disease invigorating the heart and spleen preparation decoction, every day, sooner or later respectively once a 100-150ml ten days was a course for the treatment of, takes 4 courses for the treatment of altogether.
The therapeutic effect of Patients With Rheumatic Valvular Disease shown in table 1:
The present invention with reinforcing the heart strengthening the spleen, nourishing blood to promote the production of body fluid for the rule for the treatment of, the multiple medical material synergistic combination of the Radix Astragali, Radix Codonopsis, Radix Morindae Officinalis, treat rheumatic heart disease targetedly, add other accessory drugss such as the beneficial will of calming the nerves of Radix Polygalae, the temperature of Ramulus Cinnamomi again and lead to effect such as astringing lung-QI and relieving cough of muscle arteries and veins, Polygonum cynanchoides Hemsl., Be very effective, its total effective rate of clinical trial certificate can reach 98.8%.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.

Claims (1)

1. the preparation method of rheumatic heart disease invigorating the heart and spleen preparation decoction, is characterized in that, get following bulk drugs: Radix Astragali 30g, Herba Rosmarini Officinalis 9g, Radix Codonopsis 12g, Radix Morindae Officinalis 12g, Massa Medicata Fermentata 9g, Rhizoma Atractylodis Macrocephalae 12.5g, Radix Angelicae Sinensis 10.5g, Radix Urenae Lobatae 12.5g, Radix Glycyrrhizae (processing) 8g, Radix Capparis Membranaceae 8.5g, Poria cum Radix Pini 11g, Radix Polygalae 6.5g, Radix Aucklandiae 10g, Ramulus Cinnamomi 9.5g, Polygonum cynanchoides Hemsl. 7.5g, Rhizoma Zingiberis Recens Fructus Gardeniae 7.5g, purple Cortex Magnoliae Officinalis 4.5g; Step is:
(1) getting Mel is placed in pot, is heated to boiling, put into Herba Rosmarini Officinalis, Radix Urenae Lobatae, Ramulus Cinnamomi, Radix Glycyrrhizae, with slow fire heating, fry to micro-yellow, drying with tack-free is standard, and taking-up cools;
(2) get the Radix Astragali, Radix Codonopsis, Radix Morindae Officinalis, the Rhizoma Atractylodis Macrocephalae, Fructus Gardeniae clean remove impurity, be cut into fragment, add Sucus Zingberis and mix thoroughly, moist 25 minutes, be placed in slow fire heating fried dry in pot, taking-up cools;
(3) Massa Medicata Fermentata, Radix Capparis Membranaceae, Poria cum Radix Pini, Polygonum cynanchoides Hemsl., purple Cortex Magnoliae Officinalis, Radix Polygalae are put into marmite, add the water soaking 30 minutes of medical material weight 6 times, big fire is heated to boiling, then adds step (1) (2) gained medical material, turn little fire to decoct 50 minutes, filter to obtain medicinal liquid;
(4) recrement adds water and continues to decoct, and the time is 35 minutes, and filtered while hot obtains medicinal liquid;
(5) get Radix Angelicae Sinensis, the rinse of Radix Aucklandiae clear water, remove impurity, put into drier, take out and pulverized 110 mesh sieves, mix homogeneously with above-mentioned gained filtrate, sterilizing encapsulation obtains Chinese medicine decoction.
CN201610075481.1A 2014-11-04 2014-11-04 Preparation method of heart and spleen tonifying decoction for treating rheumatic heart diseases Withdrawn CN105535186A (en)

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