CN105688050A - Traditional Chinese medicine composition for treating posthepatitic cirrhosis portal hypertension - Google Patents
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Abstract
The invention relates to traditional Chinese medicine composition for treating posthepatitic cirrhosis portal hypertension and belongs to the technical field of medicines. The traditional Chinese medicine composition is prepared from raw materials in parts by weight as follows: 9-15 parts of erigeron breviscapus, 6-12 parts of roots or all-grass of Aleppo Avens, 10-15 parts of herbs of flexuose climbing fern, 3-10 parts of hawthorn leaves, 1-3 parts of saffron, 5-9 parts of rhizome corydalis, 3-10 parts of rhizoma Chuanxiong, 9-15 parts of ovientvine, 10-15 parts of clam shells, 3-15 parts of largehead atractylodes rhizomes, 6-15 parts of pilose asiabell roots, 5-10 parts of perilla stems, 6-15 parts of tangerine leaves, 3-10 parts of turmeric root-tuber, 3-9 parts of bitter oranges, 6-12 parts of Chinese angelica and 5-10 parts of white peony roots. The traditional Chinese medicine composition has the efficacy of dispelling wind, eliminating dampness, activating blood, removing blood stasis, regulating qi, dredging meridians, softening hardness to dissipate stagnation, relieving swelling and pain, invigorating the spleen, tonifying qi, soothing liver, promoting qi circulation, removing food retention, relieving depression and the like, has a remarkably curative effect on posthepatitic cirrhosis portal hypertension, has a mild property, does not have any toxic or side effects and has high safety.
Description
[technical field]
The present invention relates to pharmaceutical technology field, especially a kind of Chinese medicine composition treating posthepatitic cirrhosis portal hypertension。
[technical background]
In China, liver cirrhosis is common with hepatitis liver cirrhosis, and mainly because chronic inflammatory disease produces inflammatory cytokine, hepatocyte hypoxic-ischemic and liver cell regeneration, injury repairing causes that hepatic fibrosis and pseudolobuli are formed and formed continuously。Liver cirrhosis early stage liver function is good, can without obvious clinical symptoms。Liver cirrhosis may occur in which that portal venous pressure raises late period, and this disease belongs to sinus hepaticus and hole rear profile, and reason mainly has: in a, liver, the fibre bundle of hypertrophy and the liver cell nodules of regeneration extrude the sinus hepaticus in lobules of liver so that it is narrow or inaccessible, cause that portal venous flow is obstructed；Pseudolobuli compressing sublobular vein in b, liver, makes blood in sinus hepaticus flow out and is obstructed, and then affects portal vein inflow sinus hepaticus；C, kiernan's space portal area Hepatic artery subbranch and portal vein subbranch between arteriovenous communication Zhi Kaifang, make pressure high hepatic artery blood flow introduction intravenous。Cirrhotic Portal Hypertension may result in the severe complication such as portal hypertension gastopathy and digestive tract hemorrhage, and human health in serious threat。At present to portal hypertension associated with liver cirrhosis except row surgical operation and interventional therapy, it is also possible to by medical treatment to reduce portal system blood flow and to reduce in liver and collateral blood vessels resistance, reduce portal venous pressure, reduce the purpose of complication。Clinical medicine great majority used are by reducing cardiac output at present, shrink visceral vessel, reduce pylic blood flow, such as beta-blocker, nitrate esters medicine, Somatostatin and terlipressin etc., although these medicines can play good curative effect within the specific limits, but long-time application can make liver blood flow amount reduce and increase the weight of liver injury, and systemic blood flow is produced harmful effect, therefore the utilization that Western medicine is in reducing portal venous pressure is subject to certain restrictions, therefore in the urgent need to seeking a kind of to treat the medicine that posthepatitic cirrhosis portal hypertension clinical efficacy is definite and side effect is little。
[summary of the invention]
For posed problems above, the invention provides a kind of Chinese medicine composition treating posthepatitic cirrhosis portal hypertension, this Chinese medicine composition for treating posthepatitic cirrhosis portal hypertension and have that effect is notable, having no side effect, safe and reliable feature。
According to the pathogenic factor of posthepatitic cirrhosis portal hypertension, pathogenesis and clinical manifestation, this disease can be belonged to " hypochondriac pain ", " gathering ", " mass in the abdomen ", " tympanites " category, its early stage belongs to the category of the traditional Chinese medical science " hypochondriac pain ", " mass in the abdomen ", " gathering ", belongs to the category of " tympanites " late period more。And according to clinical experience for many years and in conjunction with Basic Theories of Chinese Medicine, think that primary disease is because of the heresy of diseases caused by exogenous pathogenic factor epidemic disease caused by damp-heat pathogen poison, in deep underlying mass, with the passing of time affect body QI-blood circulation, accumulatively wet raise phlegm, forming the pathological products such as tired wet, addiction blood, phlegm-damp, tired blood as pathologic basis and paathogenic factor, can increase the weight of liver injury again further, cause depression of liver-QI, dysfunction of the spleen in transportation, forms stagnation of liver-QI with deficiency of the spleen, the stagnant card of tired dampness。
In order to realize above-mentioned purpose, the technical solution adopted in the present invention is:
A kind of Chinese medicine composition treating posthepatitic cirrhosis portal hypertension, it includes the raw material of following weight portion: Herba Erigerontis 9-15 part, ZHUIFENGCAO 6-12 part, Herba Lygodii Flexuosi 10-15 part, Folium Crataegi 3-10 part, Stigma Croci 1-3 part, Rhizoma Corydalis 5-9 part, Rhizoma Chuanxiong 3-10 part, Caulis Sinomenii 9-15 part, Concha Meretricis Seu Cyclinae 10-15 part, Rhizoma Atractylodis Macrocephalae 3-15 part, Radix Codonopsis 6-15 part, Caulis Perillae 5-10 part, Folium Citri tangerinae 6-15 part, Radix Curcumae 3-10 part, Fructus Aurantii 3-9 part, Radix Angelicae Sinensis 6-12 part, Radix Paeoniae Alba 5-10 part。
Further, described Chinese medicine composition includes the raw material of following weight portion: Herba Erigerontis 11-13 part, ZHUIFENGCAO 8-10 part, Herba Lygodii Flexuosi 12-14 part, Folium Crataegi 4-8 part, Stigma Croci 2-3 part, Rhizoma Corydalis 6-8 part, Rhizoma Chuanxiong 4-8 part, Caulis Sinomenii 11-13 part, Concha Meretricis Seu Cyclinae 12-14 part, Rhizoma Atractylodis Macrocephalae 7-11 part, Radix Codonopsis 8-12 part, Caulis Perillae 7-9 part, Folium Citri tangerinae 8-12 part, Radix Curcumae 5-9 part, Fructus Aurantii 5-7 part, Radix Angelicae Sinensis 8-10 part, Radix Paeoniae Alba 7-9 part。
Further, described Chinese medicine composition includes the raw material of following weight portion: Herba Erigerontis 12 parts, ZHUIFENGCAO 9 parts, Herba Lygodii Flexuosi 13 parts, Folium Crataegi 7 parts, Stigma Croci 2 parts, Rhizoma Corydalis 7 parts, Rhizoma Chuanxiong 6 parts, Caulis Sinomenii 12 parts, Concha Meretricis Seu Cyclinae 13 parts, the Rhizoma Atractylodis Macrocephalae 9 parts, Radix Codonopsis 10 parts, Caulis Perillae 8 parts, Folium Citri tangerinae 10 parts, Radix Curcumae 7 parts, Fructus Aurantii 6 parts, Radix Angelicae Sinensis 9 parts, the Radix Paeoniae Alba 8 parts。
Further, the preparation method of described Chinese medicine composition is: pick described raw material according to above-mentioned weight portion, clean dry after, mixing put in marmite, add raw material gross weight 5-8 times water soaking 40-60min, intense fire turns slow fire boiling 20-40min after boiling, then filtering, filtrate retains, and filtering residue then adopts same procedure to continue to decoct 2 times, finally merge 3 times and decoct gained filtrate, obtain described Chinese medicine composition。
Further, described Chinese medicine composition can be applicable to, in the preparation of the medicine for the treatment of posthepatitic cirrhosis portal hypertension, with pharmaceutically acceptable adjuvant method of Chinese medicinal conventionally, it to be prepared into any conventional oral formulations。
Further, described Chinese medicine preparation is granule, powder, capsule, tablet, pill or oral liquid。
Instructions of taking: each take the Chinese medicine preparation that effective dose is 1-2g, daily 3 times, early, middle and late decoction being taken warmly half an hour after meal, one month is a course for the treatment of, and period of taking medicine withdraws other drug, and avoid eating anything raw or cold, pungent, the food that stimulates。
Chinese medicine details of the present invention is as follows:
Herba Erigerontis: for the dry herb of Compositae wingceltis thing Erigeron breviscapus (Vant.) Hand.-Mazz.。Acrid in the mouth, micro-hardship, warm in nature。GUIXIN, Liver Channel。There is expelling cold and relieving exterior syndrome, expelling wind and removing dampness, invigorate blood circulation active, effect of pain relieving。For headache due to common cold, toothache, stomachache, rheumatic arthralgia, the paralysis that cerebrovas-cularaccident causes, osteomyelitis。
ZHUIFENGCAO: sweet in the mouth is pungent, property is put down。There is expelling wind and removing dampness, effect of promoting blood circulation and detumescence。Control waist-leg arthralgia pain, dysentery, metrorrhagia leucorrhea, traumatic injury, ulcer sores, pharyngalgia, scrofula。" Shaanxi Chinese herbal medicine ": expelling wind and removing dampness, dissipating blood stasis for subsidence of swelling, anti-inflammatory analgetic, relieving convulsion。Control lumbago and skelalgia, traumatic injury, dysentery, metrorrhagia, leucorrhea, infantile convulsion, acute mastitis, pharyngalgia, tonsillitis, ulcer sores, scrofula。
Herba Lygodii Flexuosi: for the herb of Lygodiaceae plant bent axle Spora Lygodii。Sweet and slightly bitter taste, cold in nature。Return kidney, liver, large intestine channel。There is relaxing muscles and tendons and activating QI and blood in the collateral, clearing away heat-damp and promoting diuresis, hemostasis。Main rheumatic numbness, traumatic injury, urinary tract infection, urinary system calculus, edema, dysentery, sore and toxic, oral aphthae in children, acute catarrhal conjunctivitis, tinea, traumatic hemorrhage。
Folium Crataegi: for the leaf of rosaceous plant Fructus Pyri Pashiae or Fructus Crataegi etc.。Sour in the mouth, property is put down。Return lung meridian。There is blood circulation promoting and blood stasis dispelling, regulate the flow of vital energy and promote blood circulation, change effect of turbid blood fat reducing。For qi depression to blood stasis, obstruction of qi in the chest and cardialgia, chest distress, palpitation and amnesia, vertigo and tinnitus, hyperlipemia。
Stigma Croci: for top and the stigma of irides Stigma Croci style。Concoct: pick decontamination, and remove yellow feeler。Sweet in the mouth, property is put down。Enter the heart, Liver Channel。There is blood circulation promoting and blood stasis dispelling, effect of dispersing stagnation and relieving accumulation of pathogens。Controlling troubled thoughts pent-up, chest and diaphragm painful abdominal mass is vexed, spits blood, and typhoid fever is gone mad, and frightened fear in a trance, women's amenorrhea, postnatal blood stasis is suffered from abdominal pain, tumbling and swelling。" product converge with essence want ": main dissipate strongly fragrant tune blood, the chest stuffiness relieving diaphragm, whet the appetite into diet, and clothes grow lower unit, improving healthy complexion and cold going mad of curing the wound for a long time。
Rhizoma Corydalis: for the tuber of papaveraceae plant corydalis。Acrid in the mouth, hardship, warm in nature。Return liver, stomach, the heart, lung, spleen channel。Have and invigorate blood circulation, dissipating blood stasis, regulate the flow of vital energy, the merit of pain relieving。Control trusted subordinate's all pains of waist knee joint, menoxenia, abdominal mass, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury。
Rhizoma Chuanxiong: for the rhizome of samphire Rhizoma Chuanxiong。Acrid in the mouth, warm in nature。Return liver, gallbladder, pericardium channel。Activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, promoting blood circulation and stopping pain。Controlling air-cooled headache rotation dizzy, difficult labour, postpartum stagnation block pain, ulcer sores, menoxenia, amenorrhea dysmenorrhea, abdominal mass is suffered from abdominal pain, breast side of body twinge, tumbling and swelling, rheumatic arthralgia。" Japan hanako materia medica ": control a wind cutting, all gas, all strains, all blood, mend five kinds of over strain, strengthening bone and muscle, adjust many arteries and veins, broken knot stagnated blood, support fresh blood, put on flesh, serious epistaxis, to spit blood and hematuria, hemorrhoid complicated by anal fistula, brain carbuncle carbuncle on the back, scrofula wart is gone to live in the household of one's in-laws on getting married, skin ulcer scabies, and evacuation of pus repercussive blood。" detailed outline ": dampness, antidiarrheal dysentery, activating QI to alleviate the depression。
Caulis Sinomenii: for the dry rattan of menispermaceous plants Sinomenium acutum and hair Sinomenium acutum。Bitter in the mouth, pungent, property is put down。Return liver, spleen channel。There is wind-damp dispelling, the meridian dredging, effect of diuresis。Dispelling the wind and dampness pathogens arthralgia pain, the arthroncus of knee, edema, beriberi。
Concha Meretricis Seu Cyclinae: for the shell of Veneridae animal Conch Meretricis seu Cyclinae or Concha Meretricis Seu Cyclinae。Summer, season in autumn two fish for, fleshing, clean, dry。Bitter in the mouth, salty, cold in nature。Return lung meridian, stomach warp。There is removing heat-phlegm, hard masses softening and resolving, effect of relieving gastric hyperacidity to alleviate stomachache。For phlegm-fire cough, pain in chest and hypochondrium, sputum mixed with blood, scrofula, goiter, acid regurgitation of having a stomachache；External treatment eczema, scalds。" detailed outline ": clearing away heat-damp and promoting diuresis, reduce phlegm drink, and removing food stagnancy gathers, and except dysentery, married woman's blood stasis blocking in the chest, the anti-antiperspirant of typhoid fever, twitches, and middle phoenix is paralysed。
The Rhizoma Atractylodis Macrocephalae: for the dry rhizome of the feverfew Rhizoma Atractylodis Macrocephalae。Bitter but sweet flavor, warm in nature。Enter spleen, stomach warp。There is spleen reinforcing, stomach reinforcing, dampness, and in, antiabortive effect。Controlling deficient QI of the spleen and stomach, anorexia, the few gas of asthenia, deficiency-distension, have loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizzy, spontaneous perspiration, nausea is uneasy。
Radix Codonopsis: for the dry root of Campanulaceae Radix Codonopsis, element flower Radix Codonopsis (RADIX CODONOPSIS PILOSULAE from Northwest of China) or radix codonpsis tangshen。Sweet in the mouth, property is put down。Return spleen, lung meridian。There is invigorating middle warmer, QI invigorating, promote the production of body fluid, effect of lung benefiting。Controlling weakness of the spleen and stomach, deficiency of both QI and blood, fatigue and lack of strength, anorexia and loose stool, interior-heat is quenched one's thirst, chronic diarrhea, proctoptosis, and the deficiency of the lung is breathed with cough, spontaneous perspiration of breathing hard, and feeble QI two loses all cards。
Caulis Perillae: the stem of wrinkle for labiate Folium Perillae, point Folium Perillae etc.。Xin Gan, tepor。Enter spleen, stomach, lung meridian。Have and regulate the flow of vital energy, Shu Yu, pain relieving, antiabortive effect。Controlling the stagnation of QI, dyspepsia, chest and diaphragm painful abdominal mass is vexed, epigastric pain, and nausea is got along well。" Bencao Tujing ": a surname is ventilated malicious。" book on Chinese herbal medicine is high former ": main alleviating distention in middle-JIAO circulation of qi promoting, disappear diet, and reduce phlegm saliva。Control dysphagia and regurgitation, only cardiac and abdominal pain。" book on Chinese herbal medicine must be joined ": soothing the liver, profit lung, regulate the flow of vital energy, and blood, resolving depression, pain relieving, surely cough, antiabortive。
Folium Citri tangerinae: for the leaf of the multiple Fructus Citri tangerinae classes such as rutaceae tangerine produced in fujian province or Zhu's Fructus Citri tangerinae。Bitter in the mouth is pungent, and property is put down。Have soothing the liver, circulation of qi promoting, reduce phlegm, effect of detumescence poison。Control hypochondriac pain, acute mastitis, lung abscess, cough, chest and diaphragm feeling of fullness, hernia。Irritability, drops in " the southern regions of the Yunnan Province book on Chinese herbal medicine ": circulation of qi promoting expectorant。Control the diseases such as cough, hernia。
Radix Curcumae: for the tuber of zingiberaceous plant RADIX CURCUMAE, Rhizoma Curcumae Longae, Guangxi zedoary, Rhizoma Curcumae or RADIX CURCUMAE from Sichuan of China。Acrid in the mouth, hardship, cold in nature。GUIXIN, liver, gallbladder meridian。There is promoting QI circulation for relieving depression, promoting blood circulation and stopping pain, effect of promoting the function of the gallbladder to alleviate jaundice。Control the chest and abdomen side of body all pains of rib, lose the heart demented, calentura coma, spit blood, epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, jaundice。Essentials of Matea Medica: circulation of qi promoting, resolving depression；Let out blood, removing blood stasis with potent drugs。Cool heat in the heart, dissipates stagnation of liver-QI。Control married woman's passages through which vital energy circulates to drive in the wrong direction。
Fructus Aurantii: for the dry immature fruit of rutaceae Citrus aurantium Linn. and variety thereof。Bitter in the mouth, acid, cold nature。Return lung, spleen, liver, stomach, large intestine channel。There is dispelling the stagnated QI, row expectorant, effect of removing food stagnancy。Control chest and diaphragm expectorant stagnant, the feeling of stuffiness in chest, coerce swollen, food stagnation, eructation, vomiting, weight, proctoptosis, uterine prolapse after dysentery。
Radix Angelicae Sinensis: for the dry root of umbelliferae angelica。Sweet in the mouth, pungent, bitter, warm in nature。Return liver, the heart, spleen channel。There is replenishing and activating blood, menstruction regulating and pain relieving, effect of loosening bowel to relieve constipation。For blood deficiency and yellow complexion, dizziness cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores。
The Radix Paeoniae Alba: for the dry root of ranunculaceae plant Radix Paeoniae。Bitter in the mouth, acid, cold nature。Return Liver Channel, spleen channel。Having nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives effect of antiperspirant。Controlling the chest and abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia。Wang Haogu: gas in reason, controls abdominal flatulence due to deficiency of the spleen, epigastric oppression, pain over the hypochondrium, frequent eructation, and lung is anxious swollen against breathing with cough, sun rhinallergosis and epistaxis, and order is puckery, deficiency of liver-blood, sun dimension suffering of illness cold and heat, and dai channel suffering of illness stomachache is full, and waist is broad as sits in water。
The invention provides a kind of Chinese medicine composition treating posthepatitic cirrhosis portal hypertension, compared with prior art, have the advantages that
The Chinese medicine composition for the treatment of posthepatitic cirrhosis portal hypertension provided by the present invention makes up a prescription according to the pathogenesis of posthepatitic cirrhosis portal hypertension, with Herba Erigerontis, ZHUIFENGCAO, Herba Lygodii Flexuosi, Folium Crataegi, Stigma Croci, Rhizoma Corydalis, Rhizoma Chuanxiong, Caulis Sinomenii, Concha Meretricis Seu Cyclinae, the Rhizoma Atractylodis Macrocephalae, Radix Codonopsis, Caulis Perillae, Folium Citri tangerinae, Radix Curcumae, Fructus Aurantii, Radix Angelicae Sinensis, the Radix Paeoniae Alba for primary raw material, wherein Herba Erigerontis, ZHUIFENGCAO, Herba Lygodii Flexuosi can expelling wind and removing dampness, expelling cold and relieving exterior syndrome, channels sootheing and network vessel quickening, reducing swelling and alleviating pain；Folium Crataegi, Stigma Croci, Rhizoma Corydalis, Rhizoma Chuanxiong, Caulis Sinomenii, Radix Angelicae Sinensis have blood circulation promoting and blood stasis dispelling, regulate the flow of vital energy promote blood circulation, effect of dispersing stagnation and relieving accumulation of pathogens；Concha Meretricis Seu Cyclinae can software eliminating stagnation；The Rhizoma Atractylodis Macrocephalae, Radix Codonopsis invigorating the spleen and benefiting QI；Caulis Perillae, Folium Citri tangerinae, Radix Curcumae, Fructus Aurantii, the Radix Paeoniae Alba can soothing the liver circulation of qi promoting, removing food stagnancy resolving depression, reduce phlegm。All medicine compatibilities above, bring out the best in each other, play altogether expelling wind and removing dampness, promoting blood circulation to remove blood stasis, regulate the flow of vital energy promote blood circulation, hard masses softening and resolving, reducing swelling and alleviating pain, invigorating the spleen and benefiting QI, soothing the liver circulation of qi promoting, removing food stagnancy resolving depression effect, can fundamentally treat posthepatitic cirrhosis portal hypertension, evident in efficacy, the property of medicine is gentle, has no side effect, safe and reliable。
[detailed description of the invention]
The following examples can help those skilled in the art to be more completely understood by the present invention, but cannot be intended to limit the present invention in any manner。
Embodiment 1
A kind of Chinese medicine composition treating posthepatitic cirrhosis portal hypertension, it includes the raw material of following weight portion: Herba Erigerontis 9 parts, ZHUIFENGCAO 6 parts, Herba Lygodii Flexuosi 10 parts, Folium Crataegi 3 parts, Stigma Croci 1 part, Rhizoma Corydalis 5 parts, Rhizoma Chuanxiong 3 parts, Caulis Sinomenii 9 parts, Concha Meretricis Seu Cyclinae 10 parts, the Rhizoma Atractylodis Macrocephalae 3 parts, Radix Codonopsis 6 parts, Caulis Perillae 5 parts, Folium Citri tangerinae 6 parts, Radix Curcumae 3 parts, Fructus Aurantii 3 parts, Radix Angelicae Sinensis 6 parts, the Radix Paeoniae Alba 5 parts。Concrete preparation method is: pick described raw material according to above-mentioned weight portion, clean after drying, mixing is put in marmite, add raw material gross weight 5 times water soaking 40min, intense fire turns slow fire boiling 20min after boiling, then filter, filtrate retains, the same procedure that then adopts filtering residue continues to decoct 2 times, finally merges 3 times and decocts gained filtrate, obtains described Chinese medicine composition。
It addition, this Chinese medicine composition can be applicable to the medicine of preparation treatment posthepatitic cirrhosis portal hypertension, namely according to this field routine method of Chinese medicinal, in this Chinese medicine composition, add pharmaceutically acceptable adjuvant, make the oral formulations such as granule, powder。
Embodiment 2
A kind of Chinese medicine composition treating posthepatitic cirrhosis portal hypertension, it includes the raw material of following weight portion: Herba Erigerontis 11 parts, ZHUIFENGCAO 8 parts, Herba Lygodii Flexuosi 12 parts, Folium Crataegi 4 parts, Stigma Croci 2 parts, Rhizoma Corydalis 6 parts, Rhizoma Chuanxiong 4 parts, Caulis Sinomenii 11 parts, Concha Meretricis Seu Cyclinae 12 parts, the Rhizoma Atractylodis Macrocephalae 7 parts, Radix Codonopsis 8 parts, Caulis Perillae 7 parts, Folium Citri tangerinae 8 parts, Radix Curcumae 5 parts, Fructus Aurantii 5 parts, Radix Angelicae Sinensis 8 parts, the Radix Paeoniae Alba 7 parts。Concrete preparation method is: pick described raw material according to above-mentioned weight portion, clean after drying, mixing is put in marmite, add raw material gross weight 6 times water soaking 45min, intense fire turns slow fire boiling 25min after boiling, then filter, filtrate retains, the same procedure that then adopts filtering residue continues to decoct 2 times, finally merges 3 times and decocts gained filtrate, obtains described Chinese medicine composition。
It addition, this Chinese medicine composition can be applicable to the medicine of preparation treatment posthepatitic cirrhosis portal hypertension, namely according to this field conventional formulation method, in this Chinese medicine composition, add pharmaceutically acceptable adjuvant, make the oral formulations such as granule, capsule。
Embodiment 3
A kind of Chinese medicine composition treating posthepatitic cirrhosis portal hypertension, it includes the raw material of following weight portion: Herba Erigerontis 12 parts, ZHUIFENGCAO 9 parts, Herba Lygodii Flexuosi 13 parts, Folium Crataegi 7 parts, Stigma Croci 2 parts, Rhizoma Corydalis 7 parts, Rhizoma Chuanxiong 6 parts, Caulis Sinomenii 12 parts, Concha Meretricis Seu Cyclinae 13 parts, the Rhizoma Atractylodis Macrocephalae 9 parts, Radix Codonopsis 10 parts, Caulis Perillae 8 parts, Folium Citri tangerinae 10 parts, Radix Curcumae 7 parts, Fructus Aurantii 6 parts, Radix Angelicae Sinensis 9 parts, the Radix Paeoniae Alba 8 parts。Concrete preparation method is: pick described raw material according to above-mentioned weight portion, clean after drying, mixing is put in marmite, add raw material gross weight 6 times water soaking 50min, intense fire turns slow fire boiling 30min after boiling, then filter, filtrate retains, the same procedure that then adopts filtering residue continues to decoct 2 times, finally merges 3 times and decocts gained filtrate, obtains described Chinese medicine composition。
It addition, this Chinese medicine composition can be applicable to the medicine of preparation treatment posthepatitic cirrhosis portal hypertension, namely according to this field conventional formulation method, in this Chinese medicine composition, add pharmaceutically acceptable adjuvant, make the oral formulations such as tablet, pill。
Embodiment 4
A kind of Chinese medicine composition treating posthepatitic cirrhosis portal hypertension, it includes the raw material of following weight portion: Herba Erigerontis 13 parts, ZHUIFENGCAO 10 parts, Herba Lygodii Flexuosi 14 parts, Folium Crataegi 8 parts, Stigma Croci 3 parts, Rhizoma Corydalis 8 parts, Rhizoma Chuanxiong 8 parts, Caulis Sinomenii 13 parts, Concha Meretricis Seu Cyclinae 14 parts, the Rhizoma Atractylodis Macrocephalae 11 parts, Radix Codonopsis 12 parts, Caulis Perillae 9 parts, Folium Citri tangerinae 12 parts, Radix Curcumae 9 parts, Fructus Aurantii 7 parts, Radix Angelicae Sinensis 10 parts, the Radix Paeoniae Alba 9 parts。Concrete preparation method is: pick described raw material according to above-mentioned weight portion, clean after drying, mixing is put in marmite, add raw material gross weight 7 times water soaking 55min, intense fire turns slow fire boiling 35min after boiling, then filter, filtrate retains, the same procedure that then adopts filtering residue continues to decoct 2 times, finally merges 3 times and decocts gained filtrate, obtains described Chinese medicine composition。
It addition, this Chinese medicine composition can be applicable to the medicine of preparation treatment posthepatitic cirrhosis portal hypertension, namely according to this field conventional formulation method, in this Chinese medicine composition, add pharmaceutically acceptable adjuvant, make the oral formulations such as granule, oral liquid。
Embodiment 5
A kind of Chinese medicine composition treating posthepatitic cirrhosis portal hypertension, it includes the raw material of following weight portion: Herba Erigerontis 15 parts, ZHUIFENGCAO 12 parts, Herba Lygodii Flexuosi 15 parts, Folium Crataegi 10 parts, Stigma Croci 3 parts, Rhizoma Corydalis 9 parts, Rhizoma Chuanxiong 10 parts, Caulis Sinomenii 15 parts, Concha Meretricis Seu Cyclinae 15 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, Radix Codonopsis 15 parts, Caulis Perillae 10 parts, Folium Citri tangerinae 15 parts, Radix Curcumae 10 parts, Fructus Aurantii 9 parts, Radix Angelicae Sinensis 12 parts, the Radix Paeoniae Alba 10 parts。Concrete preparation method is: pick described raw material according to above-mentioned weight portion, clean after drying, mixing is put in marmite, add raw material gross weight 8 times water soaking 60min, intense fire turns slow fire boiling 40min after boiling, then filter, filtrate retains, the same procedure that then adopts filtering residue continues to decoct 2 times, finally merges 3 times and decocts gained filtrate, obtains described Chinese medicine composition。
It addition, this Chinese medicine composition can be applicable to the medicine of preparation treatment posthepatitic cirrhosis portal hypertension, namely according to this field conventional formulation method, in this Chinese medicine composition, add pharmaceutically acceptable adjuvant, make the oral formulations such as granule, tablet, pill。
Clinical observation statistics
1, the object of observation:
Selecting posthepatitic cirrhosis Patients With Portal Hypertension 300 example made a definite diagnosis to carry out clinical observation, cardinal symptom has: mass in the abdomen, xerostomia hardship, picture of the tongue, pulse condition etc. under splenomegaly, stomach hypersplenism, intestinal congestion, seroperitoneum, Doppler flow mapping formation, hypochondriac pain, weak, poor appetite, abdominal distention, the side of body。It is randomly divided into treatment group and matched group, treatment group 150 example, wherein male 78 example, women 72 example, age 25-65 year, the shortest person of the course of disease 2 years, most elder 10 years；Matched group 150 example, wherein, male 81 example, women 69 example, age 22-60 year, the shortest person of the course of disease 2 years half, most elder 10 years。Treatment group and the sex of two groups of cases of matched group, age, the state of an illness are basically identical, without significant difference, have comparability。
2, Therapeutic Method
Treatment group: Chinese medicine preparation of the present invention for oral administration, every day 3 times, each take the Chinese medicine preparation that effective dose is 1-2g, early, middle and late decoction being taken warmly half an hour after meal, it within 1 month, it is a course for the treatment of, observing after taking 2-6 the course for the treatment of, period of taking medicine withdraws other drug, and avoid eating anything raw or cold, pungent, the food that stimulates。
Matched group: the medicine (such as Propranolol) of the oral treatment posthepatitic cirrhosis portal hypertension bought on the market, take according to taking explanation, carrying out Synchronous with treatment group, period of taking medicine withdraws other drug, and avoid eating anything raw or cold, pungent, the food that stimulates。
4, treatment standard
Cure: the various transference cures of posthepatitic cirrhosis portal hypertension, follow up a case by regular visits to half a year without recidivist；Effective: liver cirrhosis induced portal hypertension shape substantially alleviates；Invalid: after medication, the liver cirrhosis induced portal hypertension shape of patient has no improvement。
5, therapeutic outcome
Treatment group and matched group clinical treatment outcome are as shown in table 1:
Table 1 treatment group and matched group clinical treatment outcome
| n | Recovery from illness | Effectively | Invalid | Total effective rate (%) | |
| Treatment group | 150 | 72 | 61 | 17 | 88.7 |
| Matched group | 150 | 35 | 58 | 57 | 62 |
By the clinical treatment outcome of upper table 1 treatment group and matched group it can be seen that treatment group 150 example, after taking 2-6 the course for the treatment of of Chinese medicine preparation that the present invention treats posthepatitic cirrhosis portal hypertension, cure 72 examples (accounting for sum 48%), effective 61 examples (account for sum 40.7%), invalid 17 examples, total effective rate is 88.7%；Matched group 150 example, takes presently commercially available treatment posthepatitic cirrhosis portal hypertension medicine, is synchronously performed with treatment group and observes, cure 35 examples (accounting for sum 23.3%), effective 58 examples (account for sum 38.7), and invalid 57 examples, total effective rate is 62%；Visible, Chinese medicine preparation of the present invention is used for treating posthepatitic cirrhosis portal hypertension effect and is substantially better than matched group marketed drugs, and cure rate is high。
Although, above the present invention is described in detail with a general description of the specific embodiments, but on basis of the present invention, it is possible to it is made some modifications or improvements, and this will be apparent to those skilled in the art。Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to the scope of protection of present invention。
Claims (7)
1. the Chinese medicine composition treating posthepatitic cirrhosis portal hypertension, it is characterised in that described Chinese medicine composition includes the raw material of following weight portion: Herba Erigerontis 9-15 part, ZHUIFENGCAO 6-12 part, Herba Lygodii Flexuosi 10-15 part, Folium Crataegi 3-10 part, Stigma Croci 1-3 part, Rhizoma Corydalis 5-9 part, Rhizoma Chuanxiong 3-10 part, Caulis Sinomenii 9-15 part, Concha Meretricis Seu Cyclinae 10-15 part, Rhizoma Atractylodis Macrocephalae 3-15 part, Radix Codonopsis 6-15 part, Caulis Perillae 5-10 part, Folium Citri tangerinae 6-15 part, Radix Curcumae 3-10 part, Fructus Aurantii 3-9 part, Radix Angelicae Sinensis 6-12 part, Radix Paeoniae Alba 5-10 part。
2. the Chinese medicine composition treating posthepatitic cirrhosis portal hypertension as claimed in claim 1, it is characterised in that described Chinese medicine composition includes the raw material of following weight portion: Herba Erigerontis 11-13 part, ZHUIFENGCAO 8-10 part, Herba Lygodii Flexuosi 12-14 part, Folium Crataegi 4-8 part, Stigma Croci 2-3 part, Rhizoma Corydalis 6-8 part, Rhizoma Chuanxiong 4-8 part, Caulis Sinomenii 11-13 part, Concha Meretricis Seu Cyclinae 12-14 part, Rhizoma Atractylodis Macrocephalae 7-11 part, Radix Codonopsis 8-12 part, Caulis Perillae 7-9 part, Folium Citri tangerinae 8-12 part, Radix Curcumae 5-9 part, Fructus Aurantii 5-7 part, Radix Angelicae Sinensis 8-10 part, Radix Paeoniae Alba 7-9 part。
3. the Chinese medicine composition treating posthepatitic cirrhosis portal hypertension as claimed in claim 2, it is characterised in that described Chinese medicine composition includes the raw material of following weight portion: Herba Erigerontis 12 parts, ZHUIFENGCAO 9 parts, Herba Lygodii Flexuosi 13 parts, Folium Crataegi 7 parts, Stigma Croci 2 parts, Rhizoma Corydalis 7 parts, Rhizoma Chuanxiong 6 parts, Caulis Sinomenii 12 parts, Concha Meretricis Seu Cyclinae 13 parts, the Rhizoma Atractylodis Macrocephalae 9 parts, Radix Codonopsis 10 parts, Caulis Perillae 8 parts, Folium Citri tangerinae 10 parts, Radix Curcumae 7 parts, Fructus Aurantii 6 parts, Radix Angelicae Sinensis 9 parts, the Radix Paeoniae Alba 8 parts。
4. the preparation method of the Chinese medicine composition of the treatment posthepatitic cirrhosis portal hypertension as described in as arbitrary in claim 1-3, it is characterized in that described preparation method is: pick described raw material according to above-mentioned weight portion, clean after drying, mixing is put in marmite, add raw material gross weight 5-8 times water soaking 40-60min, intense fire turns slow fire boiling 20-40min after boiling, then filter, filtrate retains, the same procedure that then adopts filtering residue continues to decoct 2 times, finally merge 3 times and decoct gained filtrate, obtain described Chinese medicine composition。
5. claim 1-3 arbitrary described Chinese medicine composition application in the medicine of preparation treatment posthepatitic cirrhosis portal hypertension。
6. the Chinese medicine preparation treating posthepatitic cirrhosis portal hypertension, it is characterised in that: described Chinese medicine preparation is the oral formulations that in the claim 1-3 by effective dose, arbitrary described Chinese medicine composition and pharmaceutically acceptable adjuvant method of Chinese medicinal conventionally are prepared from。
7. the Chinese medicine preparation for the treatment of posthepatitic cirrhosis portal hypertension according to claim 6, it is characterised in that: described Chinese medicine preparation is granule, powder, capsule, tablet, pill or oral liquid。
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Application publication date: 20160622 |