CN102423442B - Double-component medicine for treating fatty liver and preparation method thereof - Google Patents
Double-component medicine for treating fatty liver and preparation method thereof Download PDFInfo
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- CN102423442B CN102423442B CN201110441850.1A CN201110441850A CN102423442B CN 102423442 B CN102423442 B CN 102423442B CN 201110441850 A CN201110441850 A CN 201110441850A CN 102423442 B CN102423442 B CN 102423442B
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Abstract
The invention discloses a double-component medicine for treating fatty liver and a preparation method thereof. The invention mainly solves the problem that the existing medicine for treating fatty liver is not suitable for long-term taking and can not simultaneously achieve stable effect, high application safety and small adverse reaction. The double-component medicine disclosed by the invention is prepared from a component A and a component B, wherein the component A is prepared from combined spicebush root extract, rhizoma corydalis extract, pseudo-ginseng powder, radix clematidis extract, black monkshood, eucommia extract and the like; and the component B is prepared from radix rehmanniae preparata extract, safflower extract, radix bupleuri extract, radix asparagi extract, radix ophiopogonis extract, radix cyathulae extract and the like. The invention also provides a preparation method of the double-component medicine. The invention is suitable for long-term taking, and has the advantages of stable effect, high application safety, small adverse reaction and the like.
Description
Technical field
What the present invention relates to is a kind of Chinese medicine composition for the treatment of fatty liver, and specifically referring to a kind of is two prescription medicines of raw material treatment fatty liver with Chinese herbal medicine, the invention still further relates to the preparation method of this medicine.
Background technology
Fatty liver is with right flank pain, discomfort, and fatigue and weakness etc. are main clinical characteristics, belongs to the categories such as the traditional Chinese medical science " hypochondriac pain ", " stasis of liver-Q and liver-blood ", " obstruction of the liver-QI ", " gathering ", " expectorant is turbid ", " blood stasis ".Theory of Chinese medical science thinks that primary disease is to stop in phlegm-damp, and the stasis blocking stagnation of QI is main pathogenesis, how because drinking and eating irregularly, depression of liver-QI, damp-heat accumulation, poisoning hinder etc. are caused a disease.Sick position, mainly liver, relates to spleen, stomach, gallbladder.Main pathological product is phlegm retention, blood stasis, the stagnation of QI.Characteristic of disease belongs to Primary Asthenia-Secondary Sthenia Syndrome.Be the deficiency of vital energy at this, mainly see deficiency of liver-QI, deficiency of spleen-QI; Be designated as damp and hot, phlegm retention, blood stasis, the stagnation of QI, and the folder of holding concurrently occurs more.In 1992, hepatopathy committee of Chinese Chinese medicine association formulated the differentiation of symptoms and signs for classification of syndrome standard of fatty liver, be damp and hot middle resistance, stagnation of liver-QI with deficiency of the spleen, the hepatic and renal YIN deficiency and obstruction of collaterals by blood stasis four types, and more with liver-depression and spleen-insufficiency type patient through clinical statistics discovery, liver-kidney yin deficiency and obstruction of collaterals by blood stasis type person are less.
Fatty liver is a kind of chronic comprehensive disease, and the course of disease is longer, is difficult for speed more, and prolonged illness must be hindered healthy energy, so reinforcing body resistance is also the very important one side for the treatment of fatty liver.The treatment of fatty liver should be paid attention to righting, and righting medicine relates to QI invigorating, enriches blood, nourishing YIN, YANG invigorating each side.Current clinical blood circulation promoting and blood stasis dispelling, damp eliminatingization are turbid is the basic skills for the treatment of fatty liver, also need in conjunction with individual patients situation and pathogenic characteristic simultaneously, fit applications heat clearing away, regulate the flow of vital energy, reduce phlegm, spleen invigorating, soothing the liver, multiple method for the treatment of and the medicine such as help digestion, can obtain satisfied curative effect.But the medicine of existing treatment fatty liver is not suitable for long-term taking, and cannot be effective simultaneously stable, use safety, the little feature of untoward reaction.
Summary of the invention
The object of the invention be to provide a kind of suitable long-term taking, effect stability, use safety, untoward reaction little be used for the treatment of two prescription medicines of fatty liver and preparation method thereof.
Realize technical scheme of the present invention as follows: a kind of two prescription medicines that are used for the treatment of fatty liver, described medicine is made up of the prescription A of 5～10 weight portions and the prescription B of 3～9 weight portions,
Described prescription A is by radix linderae extract, Radix Salviae Miltiorrhizae extract, Rhizoma Corydalis extract, Radix Notoginseng powder, Radix Clematidis extract, Radix Aconiti Lateralis Preparata, Cortex Eucommiae extract, Radix Achyranthis Bidentatae extract, Radix Bupleuri extract, Rhizoma Chuanxiong extract, Oletum Trogopterori; Margarita powder, artificial Calculus Bovis, Borneolum Syntheticum, Ganoderma spore powder, Radix Sophorae Flavescentis extract, oligochitosan, Semen Vitis viniferae extract, resveratrol extract, Radix Ginseng extract, Herba Epimedii extract, Herba Lysimachiae extract, Herba Hedyotidis Diffusae extract, Herba Scutellariae Barbatae extract and vitamin C composition
Described prescription B is by Fructus Crataegi extract, Radix Aucklandiae extract, Radix Astragali extract, Radix Clematidis extract, Fructus Jujubae extract, Radix Angelicae Sinensis extract, Rhizoma Chuanxiong extract, Radix Paeoniae Rubra extract, Semen Persicae extract, Radix Bupleuri extract, Rhizoma Atractylodis Macrocephalae extract, Rhizoma Alismatis extract, Fructus Hordei Germinatus extract, Radix Rehmanniae Preparata extract, Flos Carthami extract, Bulbus Fritillariae Cirrhosae extract, Cortex Eucommiae extract, Fructus Ligustri Lucidi extract, Fructus Lycii extract, radix linderae extract, Radix Salviae Miltiorrhizae extract, Rhizoma Smilacis Glabrae extract, Rhizoma Gastrodiae extract, Radix Codonopsis extract, Radix Asparagi extract, Radix Ophiopogonis extract, Radix Cyathulae extract, Cortex Cinnamomi extract, Fructus Schisandrae Chinensis extrat, oligochitosan composition.
Further, described prescription A and prescription B are made up of the component of following weight portion,
Prescription A: 1～4 part of radix linderae extract, 1～4 part of Radix Salviae Miltiorrhizae extract, 1～4 part of Rhizoma Corydalis extract, 1～4 part of Radix Notoginseng powder, 1～4 part of Radix Clematidis extract, 1～4 part of Radix Aconiti Lateralis Preparata, 1～4 part of Cortex Eucommiae extract, 1～4 part of Radix Achyranthis Bidentatae extract, 1～4 part of Radix Bupleuri extract, 1～4 part of Rhizoma Chuanxiong extract, 1～4 part of Oletum Trogopterori, 1～4 part of Margarita powder, 1～4 part of artificial Calculus Bovis, 1～4 part of Borneolum Syntheticum, 10～25 parts of Ganoderma spore powders, 4～12 parts of oligochitosans, 2～6 parts of Radix Sophorae Flavescentis extracts, 1～3 part of Semen Vitis viniferae extract, 1～4 part of resveratrol extract, 3～9 parts of Radix Ginseng extracts, 3～9 parts of Herba Epimedii extracts, 5～15 parts of Herba Lysimachiae extracts, 10～30 parts of Herba Hedyotidis Diffusae extracts, 5～15 parts of Herba Scutellariae Barbatae extracts, 1～4 part of vitamin C,
Prescription B: 10～30 parts of Fructus Crataegi extracts, 5～15 parts of Radix Aucklandiae extracts, 6～18 parts of Radix Astragali extracts, 3～9 parts of Radix Clematidis extracts, 3～9 parts of Fructus Jujubae extracts, 1～4 part of Radix Angelicae Sinensis extract, 1～4 part of Rhizoma Chuanxiong extract, 2～5 parts of Radix Paeoniae Rubra extracts, 1～4 part, Semen Persicae extract, 1～4 part of Rhizoma Alismatis extract, 3～9 parts of Fructus Hordei Germinatus extracts, 2～6 parts of Radix Rehmanniae Preparata extracts, 1～4 part of Flos Carthami extract, 1～4 part of Bulbus Fritillariae Cirrhosae extract, 2～6 parts of Cortex Eucommiae extract, 3～9 parts of Fructus Ligustri Lucidi extracts, 3～9 parts of Fructus Lycii extracts, 1～4 part of radix linderae extract, 3～9 parts of Fructus Schisandrae Chinensis extrats, 2～6 parts of Rhizoma Atractylodis Macrocephalae extracts, 2～6 parts of Radix Bupleuri extracts, 1～4 part of Radix Salviae Miltiorrhizae extract, 6～18 parts of Rhizoma Smilacis Glabrae extracts, 1～4 part of Rhizoma Gastrodiae extract, 1～4 part of Radix Codonopsis extract, 1～4 part of Radix Asparagi extract, 1～4 part of Radix Ophiopogonis extract, 2～6 parts of Radix Cyathulae extracts, 1～4 part of Cortex Cinnamomi extract, 1～3 part of oligochitosan.
Further, described prescription A and prescription B are made up of the component of following weight portion,
Prescription A: 2 parts of radix linderae extracts, 2 parts of Radix Salviae Miltiorrhizae extracts, 2 parts of Rhizoma Corydalis extracts, 2 parts of Radix Notoginseng powder, 2 parts of Radix Clematidis extracts, 2 parts of Radix Aconiti Lateralis Preparatas, 2 parts of Cortex Eucommiae extract, 2 parts of Radix Achyranthis Bidentatae extracts, 2 parts of Radix Bupleuri extracts, 2 parts of Rhizoma Chuanxiong extracts, 2 parts of Oletum Trogopteroris, 2 parts of Margarita powder, 2 parts of artificial Calculus Boviss, 2 parts of Borneolum Syntheticums, 16 parts of Ganoderma spore powders, 8 parts of oligochitosans, 4 parts of Radix Sophorae Flavescentis extracts, 1 part of Semen Vitis viniferae extract, 2 parts of resveratrol extracts, 6 parts of Radix Ginseng extracts, 6 parts of Herba Epimedii extracts, 10 parts of Herba Lysimachiae extracts, 20 parts of Herba Hedyotidis Diffusae extracts, 10 parts of Herba Scutellariae Barbatae extracts, 2 parts of vitamin Cs,
Prescription B: 20 parts of Fructus Crataegi extracts, 10 parts of Radix Aucklandiae extracts, 12 parts of Radix Astragali extracts, 6 parts of Radix Clematidis extracts, 6 parts of Fructus Jujubae extracts, 2 parts of Radix Angelicae Sinensis extracts, 2 parts of Rhizoma Chuanxiong extracts, 3 parts of Radix Paeoniae Rubra extracts, 2 parts, Semen Persicae extract, 2 parts of Rhizoma Alismatis extracts, 6 parts of Fructus Hordei Germinatus extracts, 4 parts of Radix Rehmanniae Preparata extracts, 2 parts of Flos Carthami extracts, 2 parts of Bulbus Fritillariae Cirrhosae extracts, 4 parts of Cortex Eucommiae extract, 6 parts of Fructus Ligustri Lucidi extracts, 6 parts of Fructus Lycii extracts, 2 parts of radix linderae extracts, 6 parts of Fructus Schisandrae Chinensis extrats, 4 parts of Rhizoma Atractylodis Macrocephalae extracts, 4 parts of Radix Bupleuri extracts, 2 parts of Radix Salviae Miltiorrhizae extracts, 12 parts of Rhizoma Smilacis Glabrae extracts, 2 parts of Rhizoma Gastrodiae extracts, 2 parts of Radix Codonopsis extracts, 2 parts of Radix Asparagi extracts, 2 parts of Radix Ophiopogonis extracts, 4 parts of Radix Cyathulae extracts, 2 parts of Cortex Cinnamomi extracts, 1 part of oligochitosan.
The preparation method of two prescription medicines, is mainly made up of following steps:
(1) prepare the various extracts in prescription A and prescription B;
(2) all the other the each components in prescription A and prescription B are pulverized respectively;
(3) by the each component mix homogeneously in prescription A, general ball makes 2～4mm piller, dry;
(4) by the each component mix homogeneously in prescription B, granulation agent or add Mel to make honeyed pill.
Further, in described step (2), in prescription A and prescription B, all the other each components are pulverized respectively rear mistake 80 mesh sieves.
Be active substance in order to make the material extracting, described extract obtains by following steps:
(1) material needs being extracted is removed impurity;
(2) will go deimpurity material to carry out pulverization process;
(3) be put in extraction pot in the ratio of 1Kg radix linderae and 10L water, refluxed 20～30 minutes, obtained extracting solution;
(4) by extracting solution suction concentration tank, concentrated this extracting solution;
(5) the spray-dried extract that makes of extracting solution after described concentrating.
The present invention has the following advantages and beneficial effect:
1, the present invention the method such as adopts food stagnation removing to mend to let out coordinate fatty liver is prevented and treated in conjunction with blood stasis dispelling damp eliminating treatment fatty liver at all, again;
2, the present invention have effect extensively, the feature of little, the suitable long-term taking of effect stability, use safety, untoward reaction;
3, the present invention, for the various a kind of methods that material high efficiency extraction effective ingredient is provided, has not only kept drug effect greatly, and has improved the extraction content of effective ingredient, has reduced production cost.
The specific embodiment
Below in conjunction with embodiment, the present invention is described in further detail, but embodiments of the present invention are not limited to this.
Embodiment 1
First, obtain the extract of various materials, the extraction step of extract is as follows:
(1) material needs being extracted is removed impurity; As radix linderae extract, the medicinal part of radix linderae is taken out;
(2) will go deimpurity material to carry out pulverization process; By pulverizer processing, be crushed to 20 orders;
(3) be put in extraction pot in the ratio of 1Kg material and 10L water, refluxed 20～30 minutes, obtained extracting solution; Extracting temperature is 100 ℃;
(4), by extracting solution suction concentration tank, concentrated this extracting solution, adopts the conventional method for concentration of the field of Chinese medicines under 90 ℃ of left and right conditions, to concentrate this extracting solution;
(5) the spray-dried radix linderae extract that makes of extracting solution after described concentrating.
Various extracts in prescription A and prescription B are all to obtain by above method.
Secondly, each component of the non-extract in prescription A and prescription B is pulverized respectively; Be crushed to its fineness and be less than or equal to 80 orders.Can in pulverizing, cross 80 object sieves herein, be less than or equal to 80 object components and just sifted out, all the other compositions are proceeded to pulverize.In the present embodiment, need pulverized component to have Radix Notoginseng powder, Radix Aconiti Lateralis Preparata, Oletum Trogopterori, Margarita powder, artificial Calculus Bovis, Borneolum Syntheticum, Ganoderma spore powder, oligochitosan and the vitamin C in prescription A, in prescription B is oligochitosan.
Moreover, by 2 parts of radix linderae extracts in prescription A, 2 parts of Radix Salviae Miltiorrhizae extracts, 2 parts of Rhizoma Corydalis extracts, 2 parts of Radix Notoginseng powder, 2 parts of Radix Clematidis extracts, 2 parts of Radix Aconiti Lateralis Preparatas, 2 parts of Cortex Eucommiae extract, 2 parts of Radix Achyranthis Bidentatae extracts, 2 parts of Radix Bupleuri extracts, 2 parts of Rhizoma Chuanxiong extracts, 2 parts of Oletum Trogopteroris, 2 parts of Margarita powder, 2 parts of artificial Calculus Boviss, 2 parts of Borneolum Syntheticums, 16 parts of Ganoderma spore powders, 8 parts of oligochitosans, 4 parts of Radix Sophorae Flavescentis extracts, 1 part of Semen Vitis viniferae extract, 2 parts of resveratrol extracts, 6 parts of Radix Ginseng extracts, 6 parts of Herba Epimedii extracts, 10 parts of Herba Lysimachiae extracts, 20 parts of Herba Hedyotidis Diffusae extracts, 10 parts of Herba Scutellariae Barbatae extracts and 2 parts of mix homogeneously of vitamin C, general ball makes the piller that diameter is 3mm.
Finally, by 20 parts of the Fructus Crataegi extracts in prescription B, 10 parts of Radix Aucklandiae extracts, 12 parts of Radix Astragali extracts, 6 parts of Radix Clematidis extracts, 6 parts of Fructus Jujubae extracts, 2 parts of Radix Angelicae Sinensis extracts, 2 parts of Rhizoma Chuanxiong extracts, 3 parts of Radix Paeoniae Rubra extracts, 2 parts, Semen Persicae extract, 2 parts of Rhizoma Alismatis extracts, 6 parts of Fructus Hordei Germinatus extracts, 4 parts of Radix Rehmanniae Preparata extracts, 2 parts of Flos Carthami extracts, 2 parts of Bulbus Fritillariae Cirrhosae extracts, 4 parts of Cortex Eucommiae extract, 6 parts of Fructus Ligustri Lucidi extracts, 6 parts of Fructus Lycii extracts, 2 parts of radix linderae extracts, 6 parts of Fructus Schisandrae Chinensis extrats, 4 parts of Rhizoma Atractylodis Macrocephalae extracts, 4 parts of Radix Bupleuri extracts, 2 parts of Radix Salviae Miltiorrhizae extracts, 12 parts of Rhizoma Smilacis Glabrae extracts, 2 parts of Rhizoma Gastrodiae extracts, 2 parts of Radix Codonopsis extracts, 2 parts of Radix Asparagi extracts, 2 parts of Radix Ophiopogonis extracts, 4 parts of Radix Cyathulae extracts, 2 parts of Cortex Cinnamomi extracts and 1 part of mix homogeneously of oligochitosan, adopt conventional method of granulating, through granulating, dry, granulate, be packaged to be the granule of every bag 3g.Or add Mel to make the honeyed pill that weight is 3g.
What the present invention adopted is the piller that prescription A is made into 3mm, and prescription B is made into the honeyed pill of 3g.
Embodiment 2
Prescription A: 3 parts of radix linderae extracts, 2 parts of Radix Salviae Miltiorrhizae extracts, 4 parts of Rhizoma Corydalis extracts, 3 parts of Radix Notoginseng powder, 2 parts of Radix Clematidis extracts, 4 parts of Radix Aconiti Lateralis Preparatas, 3 parts of Cortex Eucommiae extract, 2 parts of Radix Achyranthis Bidentatae extracts, 3 parts of Radix Bupleuri extracts, 2 parts of Rhizoma Chuanxiong extracts, 1 part of Oletum Trogopterori, 4 parts of Margarita powder, 2 parts of artificial Calculus Boviss, 3 parts of Borneolum Syntheticums, 14 parts of Ganoderma spore powders, 10 parts of oligochitosans, 5 parts of Radix Sophorae Flavescentis extracts, 3 parts of Semen Vitis viniferae extracts, 4 parts of resveratrol extracts, 5 parts of Radix Ginseng extracts, 7 parts of Herba Epimedii extracts, 13 parts of Herba Lysimachiae extracts, 23 parts of Herba Hedyotidis Diffusae extracts, 13 parts of Herba Scutellariae Barbatae extracts, 3 parts of vitamin Cs,
Prescription B: 10 parts of Fructus Crataegi extracts, 13 parts of Radix Aucklandiae extracts, 7 parts of Radix Astragali extracts, 8 parts of Radix Clematidis extracts, 4 parts of Fructus Jujubae extracts, 4 parts of Radix Angelicae Sinensis extracts, 3 parts of Rhizoma Chuanxiong extracts, 4 parts of Radix Paeoniae Rubra extracts, 2 parts, Semen Persicae extract, 3 parts of Rhizoma Alismatis extracts, 7 parts of Fructus Hordei Germinatus extracts, 3 parts of Radix Rehmanniae Preparata extracts, 4 parts of Flos Carthami extracts, 2 parts of Bulbus Fritillariae Cirrhosae extracts, 3 parts of Cortex Eucommiae extract, 5 parts of Fructus Ligustri Lucidi extracts, 8 parts of Fructus Lycii extracts, 4 parts of radix linderae extracts, 3 parts of Fructus Schisandrae Chinensis extrats, 3 parts of Rhizoma Atractylodis Macrocephalae extracts, 5 parts of Radix Bupleuri extracts, 2 parts of Radix Salviae Miltiorrhizae extracts, 15 parts of Rhizoma Smilacis Glabrae extracts, 3 parts of Rhizoma Gastrodiae extracts, 1 part of Radix Codonopsis extract, 4 parts of Radix Asparagi extracts, 3 parts of Radix Ophiopogonis extracts, 5 parts of Radix Cyathulae extracts, 3 parts of Cortex Cinnamomi extracts, 3 parts of oligochitosans.
Embodiment 3
Prescription A: 1 part of radix linderae extract, 3 parts of Radix Salviae Miltiorrhizae extracts, 3 parts of Rhizoma Corydalis extracts, 3 parts of Radix Notoginseng powder, 3 parts of Radix Clematidis extracts, 2 parts of Radix Aconiti Lateralis Preparatas, 3 parts of Cortex Eucommiae extract, 4 parts of Radix Achyranthis Bidentatae extracts, 1 part of Radix Bupleuri extract, 3 parts of Rhizoma Chuanxiong extracts, 2 parts of Oletum Trogopteroris, 3 parts of Margarita powder, 4 parts of artificial Calculus Boviss, 1 part of Borneolum Syntheticum, 20 parts of Ganoderma spore powders, 8 parts of oligochitosans, 5 parts of Radix Sophorae Flavescentis extracts, 3 parts of Semen Vitis viniferae extracts, 2 parts of resveratrol extracts, 4 parts of Radix Ginseng extracts, 5 parts of Herba Epimedii extracts, 12 parts of Herba Lysimachiae extracts, 13 parts of Herba Hedyotidis Diffusae extracts, 11 parts of Herba Scutellariae Barbatae extracts, 4 parts of vitamin Cs,
Prescription B: 27 parts of Fructus Crataegi extracts, 14 parts of Radix Aucklandiae extracts, 10 parts of Radix Astragali extracts, 4 parts of Radix Clematidis extracts, 7 parts of Fructus Jujubae extracts, 3 parts of Radix Angelicae Sinensis extracts, 2 parts of Rhizoma Chuanxiong extracts, 3 parts of Radix Paeoniae Rubra extracts, 4 parts, Semen Persicae extract, 3 parts of Rhizoma Alismatis extracts, 5 parts of Fructus Hordei Germinatus extracts, 5 parts of Radix Rehmanniae Preparata extracts, 4 parts of Flos Carthami extracts, 3 parts of Bulbus Fritillariae Cirrhosae extracts, 4 parts of Cortex Eucommiae extract, 6 parts of Fructus Ligustri Lucidi extracts, 5 parts of Fructus Lycii extracts, 2 parts of radix linderae extracts, 7 parts of Fructus Schisandrae Chinensis extrats, 5 parts of Rhizoma Atractylodis Macrocephalae extracts, 4 parts of Radix Bupleuri extracts, 3 parts of Radix Salviae Miltiorrhizae extracts, 16 parts of Rhizoma Smilacis Glabrae extracts, 1 part of Rhizoma Gastrodiae extract, 2 parts of Radix Codonopsis extracts, 4 parts of Radix Asparagi extracts, 3 parts of Radix Ophiopogonis extracts, 4 parts of Radix Cyathulae extracts, 3 parts of Cortex Cinnamomi extracts, 2 parts of oligochitosans.
Instructions of taking:
Get 1～3 of the honeyed pill that makes according to prescription B, break up by warm water; Get the piller 5～10g making according to prescription A, B is used in conjunction with prescription again, every day three times, takes 3 months.
Detection method is as follows:
Select 104 Patients with Fatty Liver, and allow it take the product making according to the present invention.Taking dose is: pill 5～10g that prescription A makes, 1～3 of the honeyed pill that prescription B makes.First 1～3 of honeyed pill prescription B being made breaks up by warm water, cooks tea and drinks, and the while is used in conjunction with piller 5～10g that prescription A makes, and every day three times, takes 6 months.Concrete consumption while taking is determined according to patient's situation.
Its testing result is: obvious effective rate reaches 76%, and total effective rate reaches 89%.And find after testing the present invention and blood stasis dispelling damp eliminating, food stagnation removing mend the method such as let out cooperatively interact can be effectively lipotropic at all, have effect extensively, the feature of little, the suitable long-term taking of effect stability, use safety, untoward reaction, there is wide application and DEVELOPMENT PROSPECT.
According to above scheme, just can well realize the present invention.
Claims (4)
1. two prescription medicines that are used for the treatment of fatty liver, is characterized in that, described medicine is made up of the prescription A of 5～10 weight portions and the prescription B of 3～9 weight portions, and described prescription A and prescription B are made up of the component of following weight portion,
Prescription A: 1～4 part of radix linderae extract, 1～4 part of Radix Salviae Miltiorrhizae extract, 1～4 part of Rhizoma Corydalis extract, 1～4 part of Radix Notoginseng powder, 1～4 part of Radix Clematidis extract, 1～4 part of Radix Aconiti Lateralis Preparata, 1～4 part of Cortex Eucommiae extract, 1～4 part of Radix Achyranthis Bidentatae extract, 1～4 part of Radix Bupleuri extract, 1～4 part of Rhizoma Chuanxiong extract, 1～4 part of Oletum Trogopterori, 1～4 part of Margarita powder, 1～4 part of artificial Calculus Bovis, 1～4 part of Borneolum Syntheticum, 10～25 parts of Ganoderma spore powders, 4～12 parts of oligochitosans, 2～6 parts of Radix Sophorae Flavescentis extracts, 1～3 part of Semen Vitis viniferae extract, 1～4 part of resveratrol extract, 3～9 parts of Radix Ginseng extracts, 3～9 parts of Herba Epimedii extracts, 5～15 parts of Herba Lysimachiae extracts, 10～30 parts of Herba Hedyotidis Diffusae extracts, 5～15 parts of Herba Scutellariae Barbatae extracts, 1～4 part of vitamin C,
Prescription B: 10～30 parts of Fructus Crataegi extracts, 5～15 parts of Radix Aucklandiae extracts, 6～18 parts of Radix Astragali extracts, 3～9 parts of Radix Clematidis extracts, 3～9 parts of Fructus Jujubae extracts, 1～4 part of Radix Angelicae Sinensis extract, 1～4 part of Rhizoma Chuanxiong extract, 2～5 parts of Radix Paeoniae Rubra extracts, 1～4 part, Semen Persicae extract, 1～4 part of Rhizoma Alismatis extract, 3～9 parts of Fructus Hordei Germinatus extracts, 2～6 parts of Radix Rehmanniae Preparata extracts, 1～4 part of Flos Carthami extract, 1～4 part of Bulbus Fritillariae Cirrhosae extract, 2～6 parts of Cortex Eucommiae extract, 3～9 parts of Fructus Ligustri Lucidi extracts, 3～9 parts of Fructus Lycii extracts, 1～4 part of radix linderae extract, 3～9 parts of Fructus Schisandrae Chinensis extrats, 2～6 parts of Rhizoma Atractylodis Macrocephalae extracts, 2～6 parts of Radix Bupleuri extracts, 1～4 part of Radix Salviae Miltiorrhizae extract, 6～18 parts of Rhizoma Smilacis Glabrae extracts, 1～4 part of Rhizoma Gastrodiae extract, 1～4 part of Radix Codonopsis extract, 1～4 part of Radix Asparagi extract, 1～4 part of Radix Ophiopogonis extract, 2～6 parts of Radix Cyathulae extracts, 1～4 part of Cortex Cinnamomi extract, 1～3 part of oligochitosan,
Said extracted thing obtains by following steps:
(1) material needs being extracted is removed impurity;
(2) will go deimpurity material to carry out pulverization process;
(3) be put in extraction pot in the ratio of 1Kg material and 10L water, refluxed 20～30 minutes, obtained extracting solution;
(4) by extracting solution suction concentration tank, concentrated this extracting solution;
(5) the spray-dried extract that makes of extracting solution after described concentrating.
2. a kind of two prescription medicines that are used for the treatment of fatty liver according to claim 1, is characterized in that, described prescription A and prescription B are made up of the component of following weight portion,
Prescription A: 2 parts of radix linderae extracts, 2 parts of Radix Salviae Miltiorrhizae extracts, 2 parts of Rhizoma Corydalis extracts, 2 parts of Radix Notoginseng powder, 2 parts of Radix Clematidis extracts, 2 parts of Radix Aconiti Lateralis Preparatas, 2 parts of Cortex Eucommiae extract, 2 parts of Radix Achyranthis Bidentatae extracts, 2 parts of Radix Bupleuri extracts, 2 parts of Rhizoma Chuanxiong extracts, 2 parts of Oletum Trogopteroris, 2 parts of Margarita powder, 2 parts of artificial Calculus Boviss, 2 parts of Borneolum Syntheticums, 16 parts of Ganoderma spore powders, 8 parts of oligochitosans, 4 parts of Radix Sophorae Flavescentis extracts, 1 part of Semen Vitis viniferae extract, 2 parts of resveratrol extracts, 6 parts of Radix Ginseng extracts, 6 parts of Herba Epimedii extracts, 10 parts of Herba Lysimachiae extracts, 20 parts of Herba Hedyotidis Diffusae extracts, 10 parts of Herba Scutellariae Barbatae extracts, 2 parts of vitamin Cs,
Prescription B: 20 parts of Fructus Crataegi extracts, 10 parts of Radix Aucklandiae extracts, 12 parts of Radix Astragali extracts, 6 parts of Radix Clematidis extracts, 6 parts of Fructus Jujubae extracts, 2 parts of Radix Angelicae Sinensis extracts, 2 parts of Rhizoma Chuanxiong extracts, 3 parts of Radix Paeoniae Rubra extracts, 2 parts, Semen Persicae extract, 2 parts of Rhizoma Alismatis extracts, 6 parts of Fructus Hordei Germinatus extracts, 4 parts of Radix Rehmanniae Preparata extracts, 2 parts of Flos Carthami extracts, 2 parts of Bulbus Fritillariae Cirrhosae extracts, 4 parts of Cortex Eucommiae extract, 6 parts of Fructus Ligustri Lucidi extracts, 6 parts of Fructus Lycii extracts, 2 parts of radix linderae extracts, 6 parts of Fructus Schisandrae Chinensis extrats, 4 parts of Rhizoma Atractylodis Macrocephalae extracts, 4 parts of Radix Bupleuri extracts, 2 parts of Radix Salviae Miltiorrhizae extracts, 12 parts of Rhizoma Smilacis Glabrae extracts, 2 parts of Rhizoma Gastrodiae extracts, 2 parts of Radix Codonopsis extracts, 2 parts of Radix Asparagi extracts, 2 parts of Radix Ophiopogonis extracts, 4 parts of Radix Cyathulae extracts, 2 parts of Cortex Cinnamomi extracts, 1 part of oligochitosan.
3. the preparation method of the two prescription medicines that are used for the treatment of fatty liver described in claim 1 or 2, is characterized in that, is made up of following steps:
(1) prepare the various extracts in prescription A and prescription B;
(2) all the other the each components in prescription A and prescription B are pulverized respectively;
(3) by the each component mix homogeneously in prescription A, general ball makes 2～4mm piller, dry;
(4) by the each component mix homogeneously in prescription B, granulation agent or add Mel to make honeyed pill;
In described step (1), extract obtains by following steps:
A. material needs being extracted is removed impurity;
B. will go deimpurity material to carry out pulverization process;
C. be put in extraction pot in the ratio of 1Kg material and 10L water, refluxed 20～30 minutes, obtained extracting solution;
D. by extracting solution suction concentration tank, concentrate this extracting solution;
E. the spray-dried extract that makes of extracting solution after described concentrating.
4. the preparation method of the two prescription medicines that are used for the treatment of fatty liver according to claim 3, is characterized in that, in described step (2), in prescription A and prescription B, all the other each components are pulverized respectively rear mistake 80 mesh sieves.
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| CN102641391A (en) * | 2012-04-23 | 2012-08-22 | 刘天岐 | Chinese wolfberry fruit fat reducing and liver nourishing pill |
| CN103599295B (en) * | 2013-11-19 | 2016-02-10 | 太和县中医院 | A kind of Chinese medicine for the treatment of fatty liver |
| CN103845446B (en) * | 2014-03-05 | 2016-07-06 | 张心昱 | A kind of Chinese medicine nursing one's health liver function |
| CN104274652A (en) * | 2014-10-28 | 2015-01-14 | 合肥丰瑞隆生物科技有限公司 | Traditional Chinese medicine for treating fatty liver |
| CN104382990A (en) * | 2014-11-21 | 2015-03-04 | 江苏鹏鹞药业有限公司 | Composition of herba epimedii, eucommia ulmoides and salviae miltiorrhizae and application of composition |
| CN113717295B (en) * | 2021-09-28 | 2022-10-18 | 遵义医科大学 | Eucommia ulmoides acidic polysaccharide, extraction method and application of eucommia ulmoides acidic polysaccharide in preparation of medicine for treating fatty liver |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1907462A (en) * | 2006-08-07 | 2007-02-07 | 张庆存 | Traditional Chinese medicine composition for treating hepatitis and fatty liver |
| CN102058843A (en) * | 2010-11-24 | 2011-05-18 | 荣成市港圆抽纱制品有限公司 | Chinese medicine composition for treating fatty liver |
| CN102233119A (en) * | 2010-05-08 | 2011-11-09 | 博安兄弟制药（中国）有限公司 | Traditional Chinese medicine composition for treating fatty liver and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1907462A (en) * | 2006-08-07 | 2007-02-07 | 张庆存 | Traditional Chinese medicine composition for treating hepatitis and fatty liver |
| CN102233119A (en) * | 2010-05-08 | 2011-11-09 | 博安兄弟制药（中国）有限公司 | Traditional Chinese medicine composition for treating fatty liver and preparation method thereof |
| CN102058843A (en) * | 2010-11-24 | 2011-05-18 | 荣成市港圆抽纱制品有限公司 | Chinese medicine composition for treating fatty liver |
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