CN105560827A - Ointment for conditioning perimenopausal syndromes and preparation method thereof - Google Patents
Ointment for conditioning perimenopausal syndromes and preparation method thereof Download PDFInfo
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- CN105560827A CN105560827A CN201510998572.8A CN201510998572A CN105560827A CN 105560827 A CN105560827 A CN 105560827A CN 201510998572 A CN201510998572 A CN 201510998572A CN 105560827 A CN105560827 A CN 105560827A
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Abstract
The invention provides an ointment for conditioning perimenopausal syndromes; the ointment is prepared from the following raw materials in parts by weight: 10-20 parts of donkey hide gelatin, 10-20 parts of a tortoise-shell glue, 5-10 parts of Chinese yam, 5-10 parts of Chinese wolfberry, 5-10 parts of mulberry, 5-8 parts of radix puerariae, 5-10 parts of rhizoma polygonati, 3-5 parts of cortex cinnamomi, 5-10 parts of poria cocos, 8-12 parts of semen ziziphi spinosae, 8-12 parts of rhizoma anemarrhenae, 8-12 parts of liquorice, 10-40 parts of walnut kernels, 10-40 parts of black sesame, 10-20 parts of rock sugar, and 20-60 parts of yellow rice wine. The ointment provided by the invention can effectively condition perimenopausal mental and physical states, and improves hectic fever, sweating, heart palpitations, chest distress, waist and neck aching pain, anxiety and other symptoms through blood replenishing and other conditioning.
Description
Technical field
The present invention relates to medicines and health protection field, be specifically related to a kind of ointment for perimenopausal syndrome conditioning and preparation method thereof.
Background technology
Climacteric refers to one period before and after postmenopausal women, period from one's mid-40s to menolipsis in 12 months, comprise from close to the menopause appearance endocrine relevant with menopause, biology and Clinical symptoms to last 1 menstruation 1 year, the namely sign of ovarian failure, being continued until after last 1 menstruation 1 year, is normal physiological change period.
But, women at climacteric due to ovarian failure, body inner estrogen level declines and causes Neuroendocrine regulation mechanism unbalance and the series of symptoms of appearance, as hectic fever, perspiration, cardiopalmus, uncomfortable in chest, waist sore neck pain, anxiety etc., is called as " perimenopausal syndrome ".Women is through disconnected year, and kidney qi degradation, deficiency of kidney-essence, rushes conception vessel void, and body is in a kind of special physiological status.Due to deficiency of kidney yin, sun loses hiding or kidney yang deficiency, and passages through which vital energy circulates loses supports, thus causes visceral dysfunction, thus suffer from a deficiency of the kidney be pathogenic this.Kidney vital essence virtual loss, must involve eight arteries and veins, deficiency of kidney-YIN, can not activating QI, and the hyperamization stasis of blood.
At present, doctor trained in Western medicine adopts Hormone Replacement Therapy, perimenopausal symptom is improved by the Estrogen and progestin of supplemented with exogenous, but U.S.'s Hormone Replacement Therapy clinical and experimental study display in recent years, combine that to increase the events of heart attack, apoplexy, breast carcinoma and pulmonary infarction etc. risky continuously.According to theory of Chinese medical science and facts have proved that long-term food and Chinese medicine conditioning can improve or slow down the symptom of perimenopausal syndrome significantly, numerous women can be made to spend climacteric stably.
Chinese patent 201510343876.0 discloses a kind of Chinese medicine preparation for the treatment of perimenopausal syndrome, and concrete Chinese medicine comprises Radix Aconiti Lateralis Preparata (being decocted first) 10g, Magnetitum (being decocted first) 30g, Os Draconis (calcined) (being decocted first) 30g, Radix Rehmanniae Preparata 10g, Fructus Corni 10g, Radix Achyranthis Bidentatae 10g, Fructus Tritici Levis 10g, Fructus Schisandrae Chinensis 6g, Radix Glycyrrhizae Preparata 6g.In side, Radix Aconiti Lateralis Preparata, Magnetitum, Os Draconis (calcined) the kidney warming YANG hyperactivity suppressing are monarch, and it is minister that Radix Rehmanniae Preparata, Fructus Corni, Fructus Schisandrae Chinensis receive kidney replenishing essence, and Fructus Tritici Levis, Radix Glycyrrhizae Preparata nourish heart arresting sweating for assistant, and Radix Achyranthis Bidentatae tying-in is for making.Full side plays invigorating heart and kidney altogether, the merit of guiding fire to origin.
Chinese patent 201510329489.1 discloses a kind of Chinese medicine composition for the treatment of perimenopausal syndrome, be made up of the raw material of Chinese medicine of following parts by weight: Rhizoma Curculiginis 10, Cortex Phellodendri 10, Herba Epimedii 15, Radix Morindae Officinalis 15, the Rhizoma Anemarrhenae 12, the Radix Rehmanniae 30, Fructus Ligustri Lucidi 15, Herba Ecliptae 15, Os Draconis 30, Concha Ostreae 30, Concha Margaritifera 30, Radix Angelicae Sinensis 20, there is nourishing kidney tonifying YIN, effect of the kidney invigorating invigorating YANG.
Summary of the invention
One object of the present invention is, provides a kind of ointment for perimenopausal syndrome conditioning, and this ointment fundamentally can improve patient and to suffer from a deficiency of the kidney symptom, has effect of nourishing YIN and benefiting blood, spleen reinforcing nourishing the stomach simultaneously.
Another object of the present invention is to provide the method preparing described ointment.
To achieve these goals, concrete scheme of the present invention is as follows:
For an ointment for perimenopausal syndrome conditioning, be made up of the raw material of following weight fraction:
Colla Corii Asini 10-20 part, Colla Plastri Testudinis 10-20 part, Rhizoma Dioscoreae 5-10 part, Fructus Lycii 5-10 part, Fructus Mori 5-10 part, Radix Puerariae 5-8 part, Rhizoma Polygonati 5-10 part, Cortex Cinnamomi 3-5 part, Poria 5-10 part, Semen Ziziphi Spinosae 8-12 part, Rhizoma Anemarrhenae 8-12 part, Radix Glycyrrhizae 8-12 part, Semen Juglandis 10-40 part, Semen Sesami Nigrum 10-40 part, crystal sugar 10-20 part, yellow wine 20-60 part.
Present invention also offers the method for the ointment for the preparation of perimenopausal syndrome conditioning, comprise the following steps:
(1) pulverize: the Colla Corii Asini and the Colla Plastri Testudinis that take described number, co-grinding is to 80-100 order, for subsequent use;
(2) concentrated solution preparation: take the Rhizoma Dioscoreae of described number, Radix Puerariae, Rhizoma Polygonati, Cortex Cinnamomi, Poria, Semen Ziziphi Spinosae, the Rhizoma Anemarrhenae, Radix Glycyrrhizae, add the purified water of 8 times of weight, backflow decocts 2-2.5 hour, filter and reclaim filtrate and filtering residue respectively, the described filtering residue reclaimed is decocted through multi-reflow, being evaporated to relative density at 70-75 DEG C after the filtrate repeatedly obtained being mixed is 1.10-1.20, obtains concentrated solution;
(3) glue is changed: the yellow wine adding described number in infusion container is heated to boiling, add the crystal sugar of described number, stirring adds the Colla Corii Asini and Colla Plastri Testudinis pulverized in step (1) after making it dissolve completely, and is constantly stirred to it and melts completely, obtains carbohydrate gum liquid;
(4) refine: the concentrated solution of step (2) gained is added in described carbohydrate gum liquid obtained in step (3), continue to stir, being concentrated into moisture is 40%-50%;
(5) batch mixing: take the Fructus Lycii of described number, Fructus Mori, Semen Juglandis, Semen Sesami Nigrum, and added in the concentrated solution in step (4), heated and stirred is even, obtains described ointment.
A kind of ointment for perimenopausal syndrome conditioning provided by the invention, according to Chinese medicine monarch, minister, the compatibility mechanism of helping, making, with Colla Corii Asini, Colla Plastri Testudinis for monarch drug, with Rhizoma Dioscoreae, Fructus Lycii, Fructus Mori, Radix Puerariae, Rhizoma Polygonati ministerial drug, with Cortex Cinnamomi, Poria, Semen Ziziphi Spinosae, the Rhizoma Anemarrhenae for adjuvant drug, with Radix Glycyrrhizae, Semen Juglandis, Semen Sesami Nigrum for making medicine.Wherein Colla Corii Asini, Colla Plastri Testudinis main attack nourishing YIN and benefiting blood, Rhizoma Dioscoreae, Fructus Lycii, Fructus Mori, Radix Puerariae, Rhizoma Polygonati spleen reinforcing nourishing the stomach, nourishing the liver and kidney, concentrate the effect reaching invigorating the spleen and replenishing QI, and Cortex Cinnamomi, Poria, Semen Ziziphi Spinosae, the Rhizoma Anemarrhenae mend fire supporing yang, dispersing cold for relieving pain, promoting diuresis to eliminate damp pathogen, strengthen effect of monarch drug and ministerial drug, Radix Glycyrrhizae, Semen Juglandis, the equal sweet in the mouth of Semen Sesami Nigrum are put down, and have effect of invigorating the spleen and replenishing QI, nourishing the liver and kidney.
By ointment provided by the invention, not only taking convenience,
Simultaneously, the method preparing ointment provided by the invention, the effective ingredient in raw material can not only be made to separate out substantially, and it is high for the utilization rate of effective ingredient in raw material, amalgamation between each composition is high, mutually work in coordination with and can play effect better, the nutritional labeling in the colla corii asini cake made is easy to absorb for the empty crowd of body equally, can not cause burden to the intestines and stomach.
The present invention is just based on allocating 5 mechanism in the traditional Chinese medical science, and a donkey-hide gelatin mate being suitable for climacteric women long-term taking of invention on the basis of long-term practice, it is good that it has mouthfeel, taking convenience, Be very effective, the advantage had no side effect.
Dosage form: be pill or unguentum.Or can through reprocessing process in powder, granule, tablet, capsule, any one in unguentum.
Ointment provided by the invention effectively can nurse one's health spirit and the physiological status of climacteric, and improves hectic fever, perspiration, cardiopalmus, uncomfortable in chest, the symptom such as waist sore neck pain, anxiety by the conditioning such as to enrich blood.Generally, depending on the situation of user, every day can take 7.5-15 gram/times, every day 2 times.
In addition, this product can be used as food long-term taking, suspends take in flu and intermenstrual period.
Detailed description of the invention
Embodiment 1:
For the donkey-hide gelatin mate of climacteric conditioning, comprise the raw material of following parts by weight: 10 parts, Colla Corii Asini, Colla Plastri Testudinis 10 parts, Rhizoma Dioscoreae 5 parts, Fructus Lycii 5 parts, Fructus Mori 5 parts, Radix Puerariae 5 parts, Rhizoma Polygonati 5 parts, Cortex Cinnamomi 3 parts, 5 parts, Poria, Semen Ziziphi Spinosae 8 parts, the Rhizoma Anemarrhenae 8 parts, 8 parts, Radix Glycyrrhizae, Semen Juglandis 15 parts, Semen Sesami Nigrum 15 parts, 10 parts, crystal sugar, yellow wine 30 parts.
The preparation method of donkey-hide gelatin mate, comprises the following steps:
(1) pulverize: take 10 parts, Colla Corii Asini, Colla Plastri Testudinis 10 parts, is crushed to 80-100 order with powder beater, for subsequent use.
(2) concentrated solution preparation: take Rhizoma Dioscoreae 5 parts, Radix Puerariae 5 parts, Rhizoma Polygonati 5 parts, Cortex Cinnamomi 3 parts, 5 parts, Poria, Semen Ziziphi Spinosae 8 parts, the Rhizoma Anemarrhenae 8 parts, 8 parts, Radix Glycyrrhizae, adds the purified water of 8 times of weight, backflow decoction 2 hours, filter to get filtrate a; In filtering residue, add the purified water of initial medical material 3 times of weight, backflow decoction 2 hours, filter to get filtrate b; In filtrate slag, add the purified water of initial medical material 3 times amount, backflow decoction 1 hour, filter to get filtrate c; Filtrate a, b, c are mixed, carries out concentrating under reduced pressure, until the relative density of mixed liquor is 1.10-1.20 (70-75 DEG C), obtain concentrated solution.
(3) glue is changed.The yellow wine adding 30 parts in the container of infusion is heated to boiling, adds 10 portions of crystal sugar, stirs and makes it dissolve.Add the Colla Corii Asini and Colla Plastri Testudinis pulverized in (1), and be constantly stirred to it and melt completely, obtain carbohydrate gum liquid.
(4) refine.Step (2) gained concentrated solution is added the carbohydrate gum liquid of step (3), continue to stir, be concentrated into moisture at 40%-50%.
(5) batch mixing.Take Fructus Lycii 5 parts, Fructus Mori 5 parts, Semen Juglandis 15 parts, Semen Sesami Nigrum 15 parts, added in the concentrated solution in step (4), and heated and stirred is even, obtains donkey-hide gelatin mate.
Embodiment 2:
For the donkey-hide gelatin mate of climacteric conditioning, comprise the raw material of following parts by weight: 15 parts, Colla Corii Asini, Colla Plastri Testudinis 15 parts, Rhizoma Dioscoreae 8 parts, Fructus Lycii 8 parts, Fructus Mori 8 parts, Radix Puerariae 8 parts, Rhizoma Polygonati 8 parts, Cortex Cinnamomi 4 parts, 6 parts, Poria, Semen Ziziphi Spinosae 10 parts, the Rhizoma Anemarrhenae 10 parts, 10 parts, Radix Glycyrrhizae, Semen Juglandis 25 parts, Semen Sesami Nigrum 25 parts, 15 parts, crystal sugar, yellow wine 40 parts.
The preparation method of donkey-hide gelatin mate of the present invention, comprises the following steps:
(1) pulverize: take 15 parts, Colla Corii Asini, Colla Plastri Testudinis 15 parts, is crushed to 80-100 order with powder beater, for subsequent use.
(2) concentrated solution preparation: take Rhizoma Dioscoreae 8 parts, Radix Puerariae 8 parts, Rhizoma Polygonati 8 parts, Cortex Cinnamomi 4 parts, 6 parts, Poria, Semen Ziziphi Spinosae 10 parts, the Rhizoma Anemarrhenae 10 parts, 10 parts, Radix Glycyrrhizae, adds the purified water of 8 times of weight, backflow decoction 2 hours, filter to get filtrate a; In filtering residue, add the purified water of initial medical material 3 times of weight, backflow decoction 2 hours, filter to get filtrate b; In filtrate slag, add the purified water of initial medical material 3 times amount, backflow decoction 1 hour, filter to get filtrate c; Filtrate a, b, c are mixed, carries out concentrating under reduced pressure, until the relative density of mixed liquor is 1.10-1.20 (70-75 DEG C), obtain concentrated solution.
(3) glue is changed.The yellow wine adding 40 parts in the container of infusion is heated to boiling, adds 15 portions of crystal sugar, stirs and makes it dissolve.Add the Colla Corii Asini and Colla Plastri Testudinis pulverized in (1), and be constantly stirred to it and melt completely, obtain carbohydrate gum liquid.
(4) refine.Step (2) gained concentrated solution is added the carbohydrate gum liquid of step (3), continue to stir, be concentrated into moisture at 40%-50%.
(5) batch mixing.Take Fructus Lycii 8 parts, Fructus Mori 8 parts, Semen Juglandis 25 parts, Semen Sesami Nigrum 25 parts, added in the concentrated solution in step (4), and heated and stirred is even, obtains donkey-hide gelatin mate.
Experimental example:
Use sample prepared by embodiment 2, in Shanghai City institute of traditional Chinese medicine to 60 45-60 year menstruation irregularises, there is the women of the symptom in various degree such as perspiration, hectic fever, vexed, cardiopalmus, uncomfortable in chest, weak, insomnia, hypomnesis, waist sore neck pain, anxiety, osteoporosis, fluctuation of blood pressure, take 3 months continuously, all obtain improvement in various degree.
Detection method: inquiring is felt the pulse, the Indexs measure such as estradiol, estriol, follicle stimulating hormone.
Result shows: recovery from illness 25 example, and take a turn for the better 30 examples, and invalid 5 examples, total effective rate is 91.6%.
Above, although the description of several embodiment of the present invention, but these embodiments just propose as an example, are not intended to limit scope of the present invention.For the embodiment that these are new, can implement in other various modes, in the scope not departing from main idea of the present invention, various omission, displacement can be carried out and change.These embodiments and its distortion, while being contained in scope of the present invention and main idea, be also contained in the invention and equivalency range thereof recorded in claims.
Claims (6)
1., for an ointment for perimenopausal syndrome conditioning, it is characterized in that, be made up of the raw material of following weight fraction:
Colla Corii Asini 10-20 part, Colla Plastri Testudinis 10-20 part, Rhizoma Dioscoreae 5-10 part, Fructus Lycii 5-10 part, Fructus Mori 5-10 part, Radix Puerariae 5-8 part, Rhizoma Polygonati 5-10 part, Cortex Cinnamomi 3-5 part, Poria 5-10 part, Semen Ziziphi Spinosae 8-12 part, Rhizoma Anemarrhenae 8-12 part, Radix Glycyrrhizae 8-12 part, Semen Juglandis 10-40 part, Semen Sesami Nigrum 10-40 part, crystal sugar 10-20 part, yellow wine 20-60 part.
2. a kind of ointment for perimenopausal syndrome conditioning according to claim 1, is characterized in that, be made up of the raw material of following weight fraction:
Colla Corii Asini 12-18 part, Colla Plastri Testudinis 13-17 part, Rhizoma Dioscoreae 6-8 part, Fructus Lycii 6-9 part, Fructus Mori 7-9 part, Radix Puerariae 6-8 part, Rhizoma Polygonati 7-10 part, Cortex Cinnamomi 3-4 part, Poria 6-8 part, Semen Ziziphi Spinosae 9-11 part, Rhizoma Anemarrhenae 9-11 part, Radix Glycyrrhizae 9-10 part, Semen Juglandis 20-30 part, Semen Sesami Nigrum 20-30 part, crystal sugar 13-17 part, yellow wine 30-45 part.
3. a kind of ointment for perimenopausal syndrome conditioning according to claim 1, is characterized in that, be made up of the raw material of following weight fraction:
15 parts, Colla Corii Asini, Colla Plastri Testudinis 18 parts, Rhizoma Dioscoreae 7 parts, Fructus Lycii 8 parts, Fructus Mori 8 parts, Radix Puerariae 7 parts, Rhizoma Polygonati 9 parts, Cortex Cinnamomi 4 parts, 7 parts, Poria, Semen Ziziphi Spinosae 10 parts, the Rhizoma Anemarrhenae 10 parts, 10 parts, Radix Glycyrrhizae, Semen Juglandis 25 parts, Semen Sesami Nigrum 25 parts, 15 parts, crystal sugar, yellow wine 40 parts.
4. prepare the method for the ointment for perimenopausal syndrome conditioning described in any one of claim 1-3, it is characterized in that, comprise the following steps:
(1) pulverize: the Colla Corii Asini and the Colla Plastri Testudinis that take described number, co-grinding is to 80-100 order, for subsequent use;
(2) concentrated solution preparation: take the Rhizoma Dioscoreae of described number, Radix Puerariae, Rhizoma Polygonati, Cortex Cinnamomi, Poria, Semen Ziziphi Spinosae, the Rhizoma Anemarrhenae, Radix Glycyrrhizae, add the purified water of 8 times of weight, backflow decocts 2-2.5 hour, filter and reclaim filtrate and filtering residue respectively, the described filtering residue reclaimed is decocted through multi-reflow, being evaporated to relative density at 70-75 DEG C after the filtrate repeatedly obtained being mixed is 1.10-1.20, obtains concentrated solution;
(3) glue is changed: the yellow wine adding described number in infusion container is heated to boiling, add the crystal sugar of described number, stirring adds the Colla Corii Asini and Colla Plastri Testudinis pulverized in step (1) after making it dissolve completely, and is constantly stirred to it and melts completely, obtains carbohydrate gum liquid;
(4) refine: the concentrated solution of step (2) gained is added in described carbohydrate gum liquid obtained in step (3), continue to stir, being concentrated into moisture is 40%-50%;
(5) batch mixing: take the Fructus Lycii of described number, Fructus Mori, Semen Juglandis, Semen Sesami Nigrum, and added in the concentrated solution in step (4), heated and stirred is even, obtains described ointment.
5. the method for the ointment for perimenopausal syndrome conditioning according to claim 4, is characterized in that,
In step (2), filter and reclaim filtrate and filtering residue respectively, the described filtering residue reclaimed is decocted through multi-reflow, specifically comprises:
The described filtrate of reclaiming is initial filtrate, the purified water of the medical material gross weight 3 times preparing described initial filtrate is added in the described filtering residue reclaimed, backflow decocts 2-2.5 hour, filter to obtain secondary filtrate, in the filtering residue reclaimed, equally again add the purified water of 3 times amount simultaneously, backflow decocts 1-1.5 hour, filters to obtain three grades of filtrates.
6. the method for the ointment for perimenopausal syndrome conditioning according to claim 4, it is characterized in that, the dosage form of described ointment is pill or unguentum.
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| CN114010736A (en) * | 2021-12-24 | 2022-02-08 | 中国人民解放军空军军医大学 | Traditional Chinese medicine composition for regulating anxiety, depression and insomnia and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106509661A (en) * | 2016-10-25 | 2017-03-22 | 刘浩 | Donkey skin cakes and preparation method thereof |
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| CN111249394A (en) * | 2020-03-24 | 2020-06-09 | 马毅 | Honey refining paste for treating climacteric syndrome of women and preparation method and application thereof |
| CN114010736A (en) * | 2021-12-24 | 2022-02-08 | 中国人民解放军空军军医大学 | Traditional Chinese medicine composition for regulating anxiety, depression and insomnia and preparation method thereof |
| CN114010736B (en) * | 2021-12-24 | 2023-06-02 | 中国人民解放军空军军医大学 | Application of traditional Chinese medicine composition in preparation of medicine for improving anxiety, depression and insomnia caused by non-alcoholic fatty liver |
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