CN102205051B - Notoginseng root hematogenic medicament and preparation method thereof - Google Patents

Abstract

The invention discloses a notoginseng root hematogenic medicament, which is prepared from the following Chinese medicines in part by weight: 250 to 350 parts of prepared ginseng notoginseng root, 250 to 350 parts of prepared polygonum multiflorum thunb., 150 to 250 parts of bletilla, 250 to 350 parts of prepared rehmannia root, 50 to 150 parts of hairy antler, 150 to 250 parts of donkey-hide glue, 100 to 200 parts of glue of tortoise plastron, 50 to 150 parts of mulberry and 150 to 250 parts of south dodder seed. The preparation method for the medicament comprises the following steps of: mixing raw materials selected according to the ratio uniformly, and crushing the mixture to form particles with 100 to 200 meshes; crushing the particle mixture to be between 20 and 50 micrometers by a superfine micro-crushing technology; and filling the mixture to form capsules by using zero medical capsules or preparing into powder, dissolved medicines or pills. The medicament has better curative effects on the treatment of anemia caused by thrombocytopenia, aplastic anemia, myeloproliferative disorder syndromes and malignancy chemotherapy, asthenic diseases caused by macronosia and the like.

Description

Notoginseng root hematogenic medicament and preparation method thereof

Technical field

The present invention relates to the field of Chinese medicines, particularly a kind of notoginseng root hematogenic medicament and preparation method thereof.

Background technology

Get the diseases such as anemia due at present behind the thrombocytopenia in the hematologic disease, aplastic anemia, myelodysplastic syndrome, the malignant tumor chemotherapy, the patient is more and more, especially aplastic anemia be harm blue or green, less, one group of syndrome of the prime of life able-bodied vital organs of the human body hemopoietic function depletion.Aplastic anemia and leukemic mortality rate account for 80% in hematopathy, and acute aplastic anemia and leukemic mortality rate account for 95%, so aplastic anemia has the title of " cephaloma ".Aplastic anemia is because of marrow hemopoietic stem cells and hematopoieticmicroenviron-ment damage, and hemopoietic function is significantly descended, so that the refractory disease of pancytopenia.Erythrocyte, leukocyte and hematoblastic minimizing are often arranged simultaneously, so Symptoms is heavier anemia, easy infection and hemorrhage.The cause of disease is divided into two kinds of constitutional and Secondary cases, and Secondary cases mostly is medicine and chemical substance, radioactive substance and some diseases cause.Primary cause is not clear.At present adopt androgens, immunosuppressant, glucocorticoids etc. in the treatment more, also often take the Chinese and western medicine Comprehensive Treatment, also can according to circumstances do splenectomy and bone marrow transplantation.Androgen is the choice drug for the treatment of aplastic anemia at present, its mechanism of action: stimulate the generation of erythropoietin, promote marrow pluripotent stem cells propagation, differentiation.The patient has certain dependency, and has serious side effect, and manlike, the hepatorenal damage of performance patient, bone be closure, hypercalcemia, edema etc. too early.

Summary of the invention

The objective of the invention is to propose a kind of notoginseng root hematogenic medicament and preparation method thereof, by using YANG invigorating and being aided with YIN nourishing, with regulating YIN and YANG, thereby promote endogenous hormone to produce, recover bone marrow normal hematopoiesis function; For due to behind treatment thrombocytopenia, aplastic anemia, myelodysplastic syndrome, the malignant tumor chemotherapy anemia and prolonged illness cause deficient disease etc. preferably curative effect are arranged.

Technical scheme of the present invention is:

A kind of notoginseng root hematogenic medicament is formed by the Chinese drug preparation of following weight portion: Radix Notoginseng 250-350 processed, Radix Polygoni Multiflori Preparata 250-350, Pseudobulbus Bletillae (Rhizoma Bletillae) 150-250, Radix Rehmanniae Preparata 250-350, Cornu Cervi Pantotrichum 50-150, Colla Corii Asini 150-250, Colla Plastri Testudinis 100-200, Fructus Mori 50-150, Semen Cuscutae 150-250.

Described notoginseng root hematogenic medicament, described Chinese medicine weight portion is: Radix Notoginseng 270-325 processed, Radix Polygoni Multiflori Preparata 275-320, Pseudobulbus Bletillae (Rhizoma Bletillae) 175-230, Radix Rehmanniae Preparata 270-320, Cornu Cervi Pantotrichum 80-125, Colla Corii Asini 180-225, Colla Plastri Testudinis 80-175, Fructus Mori 75-120, Semen Cuscutae 180-230.

Described notoginseng root hematogenic medicament, described Chinese medicine weight portion is: Radix Notoginseng 300 processed, Radix Polygoni Multiflori Preparata 300, the Pseudobulbus Bletillae (Rhizoma Bletillae) 200, Radix Rehmanniae Preparata 300, Cornu Cervi Pantotrichum 100, Colla Corii Asini 200, Colla Plastri Testudinis 150, Fructus Mori 100, Semen Cuscutae 200.

Described medicine is made capsule, powder, electuary or pill.

The preparation method of above-mentioned notoginseng root hematogenic medicament may further comprise the steps:

(1), the raw material that will choose according to aforementioned proportion, except dust, impurity and non-medicinal part and fully dry;

(2), with the above-mentioned raw materials mix homogeneously, mixture is crushed to the 100-200 order;

(3), by the ultra-fine grinding technology mixture in (2) is crushed to the 20-50 micron.

Described step (3) mixture becomes capsule with No. zero medical capsule fill.

Described step (3) mixture is made powder, electuary or pill.

Beneficial effect of the present invention:

The present invention is mainly take Radix Notoginseng processed, Radix Polygoni Multiflori Preparata as monarch drug, and the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Rehmanniae Preparata, Cornu Cervi Pantotrichum are ministerial drug, and Colla Corii Asini, Colla Plastri Testudinis are adjuvant drug, and Fructus Mori and Semen Cuscutae be for making medicine, and all medicines share that gathering altogether nourishes blood enriches blood, the effect of adjusting and reinforcing liver and kidney, spermatogenesis benefit marrow.

Radix Notoginseng sweet in the mouth processed, little hardship, warm in nature are returned liver stomach warp, contain seven Saponins, seven Saponin second and flavonoid glycoside; Can stop blooding blood stasis dispelling, reducing swelling and alleviating pain, lifting platelet.

Radix Polygoni Multiflori Preparata bitter in the mouth, sweet puckery, warm in nature, GUIXIN Liver and kidney warp has that YIN nourishing is strong, the effect of benefiting essence-blood.

Pseudobulbus Bletillae (Rhizoma Bletillae) bitter in the mouth, sweet puckery, cold nature are returned lung stomach Liver Channel, and the effect of astringing to arrest bleeding, detumescence and promoting granulation is arranged.

Radix Rehmanniae Preparata sweet in the mouth slightly warm in nature, GUIXIN Liver and kidney warp has nourishing YIN and supplementing blood, strong, blood sugar lowering, heart tonifying, diuresis, antianaphylactic effect.

Cornu Cervi Pantotrichum salty in the mouth temperature is returned the Liver and kidney warp, and warming the kidney to invigorate YANG is arranged, strengthening muscles and invigorating stomach, spermatogenesis benefit blood.

Colla Corii Asini sweet in the mouth, property are flat, return lung Liver and kidney warp, have enrich blood, hemostasis, YIN nourishing, the effect of moisturizing, can increase erythrocyte, hemoglobin content in the blood, by the Nutrition of the materials such as aminoacid, improve function and the hemopoietic function of whole body, the effect of prevention progressive muscular dystrophy is arranged.

Colla Plastri Testudinis salty in the mouth, sweet, property are flat, return the Liver and kidney warp, can analgesic calmness, strengthening the tendons and bones, YIN nourishing, removing heat from blood enrich blood, tonify deficiency labor various symptoms and signs of deficiency.

Fructus Mori sweet in the mouth, little acid, warm in nature, GUIXIN Liver and kidney warp has the effect of nourishing blood to expel wind, liver and kidney tonifying.

Semen Cuscutae acrid-sweet flavor, property are flat, return the Liver and kidney warp, have liver and kidney tonifying, benefit smart, make eye bright, the effect of antidiarrheal.

This prescription has lifting erythrocyte, hemoglobin, leukocyte, platelet in various degree and improves Microcirculation in Bone Marrow, adjusts body immunity function, antibiotic antitoxic action.Invigorating the spleen and benefiting QI that these medicines have, promotion of blood circulation, heat-clearing and toxic substances removing, cooling blood for hemostasis, nourishing the liver and kidney, the smart function of the benefit that nourishes blood be for the pancytopenia diseases such as aplastic anemia therapeutical effect targetedly, and the disease of hemopoietic lack of material is had good therapeutic effect.

For proving above-mentioned advantage, it is apparent in view that medicine of the present invention has carried out the clinical verification curative effect of capsule in following examples 1, and curative effect is as follows:

1. the experimenter originates and sample content

The experimenter derives from regeneration barrier property anemia 25 examples of making a definite diagnosis, myelodysplastic syndrome 20 examples, due to behind the malignant tumor chemotherapy anemia 18 examples, male's 35 examples wherein, women's 28 examples, age 18-45 year, the course of disease 3 months～2 years.

2. usage and dosage and the course for the treatment of:

Take every day 3 times, each serving the 2-3 gram, take with warm water or Common Jujube tea, described Common Jujube tea is the immersion liquid of extra dry red wine Fructus Jujubae in water, and be 45-60 days a course for the treatment of.

3. efficacy assessment standard:

(1) produce effects: hemoglobin, platelet, the equal clinical recovery of leukocyte, taking medicine continuously to keep the state of an illness to alleviate.

(2) take a turn for the better: various hemocytees recover normal range substantially, take medicine continuously to keep stable disease.

(3) do not heal: symptom and sign and lab testing are without improvement.

4. therapeutic outcome: take medicine the fruit that takes effect a rear course for the treatment of; Have remarkable result 3 courses for the treatment of, and various hemocytees recover normal range substantially; 4-5 the course for the treatment of hemoglobin, platelet, the equal clinical recovery of leukocyte is then consolidated 3-6 the course for the treatment of again, taking medicine in the interval, to strengthen patient's body constitution, no longer sends out multiple.Produce effects person 58 among all patients, and the responder 5, and the nonresponder is without, total effective rate 100%.

5. safety adverse events: in process of the test, do not observe other obvious adverse reaction.

6. conclusion:

(1) medicine of the present invention adopts pure natural animal and plant medicine, refining forming, and prescription is scientific and reasonable, and the patient takes safe ready; By using YANG invigorating and being aided with YIN nourishing, with regulating YIN and YANG, thereby promote endogenous hormone to produce, recover bone marrow normal hematopoiesis function;

(2) scope of application: acute and chronic regeneration barrier property anemia, myelodysplastic syndrome, due to behind the malignant tumor chemotherapy anemia, prolonged illness causes deficient disease etc.

The specific embodiment

Embodiment 1:

A kind of notoginseng root hematogenic medicament contains following component (kg): Radix Notoginseng 300 processed, Radix Polygoni Multiflori Preparata 300, the Pseudobulbus Bletillae (Rhizoma Bletillae) 200, Radix Rehmanniae Preparata 300, Cornu Cervi Pantotrichum 100, Colla Corii Asini 200, Colla Plastri Testudinis 150, Fructus Mori 100, Semen Cuscutae 200.

Preparation method may further comprise the steps:

(1), the raw material that will choose according to aforementioned proportion, except dust, impurity and non-medicinal part and fully dry;

(2), with the above-mentioned raw materials mix homogeneously, mixture is crushed to 100 orders;

(3), by the ultra-fine grinding technology mixture in (2) is crushed to 50 microns.

(4), mixture becomes capsule with No. zero medical capsule fill.

Embodiment 2:

A kind of notoginseng root hematogenic medicament contains following component (kg): Radix Notoginseng 270 processed, Radix Polygoni Multiflori Preparata 275, the Pseudobulbus Bletillae (Rhizoma Bletillae) 175, Radix Rehmanniae Preparata 270, Cornu Cervi Pantotrichum 80, Colla Corii Asini 180, Colla Plastri Testudinis 80, Fructus Mori 75, Semen Cuscutae 180.

Preparation method may further comprise the steps:

(1), the raw material that will choose according to aforementioned proportion, except dust, impurity and non-medicinal part and fully dry;

(2), with the above-mentioned raw materials mix homogeneously, mixture is crushed to 200 orders;

(3), by the ultra-fine grinding technology mixture in (2) is crushed to 20 microns.

(4), mixture becomes capsule with No. zero medical capsule fill.

Embodiment 3:

A kind of notoginseng root hematogenic medicament contains following component (kg): Radix Notoginseng 325 processed, Radix Polygoni Multiflori Preparata 320, the Pseudobulbus Bletillae (Rhizoma Bletillae) 230, Radix Rehmanniae Preparata 320, Cornu Cervi Pantotrichum 125, Colla Corii Asini 225, Colla Plastri Testudinis 175, Fructus Mori 120, Semen Cuscutae 230.

Preparation method may further comprise the steps:

(1), the raw material that will choose according to aforementioned proportion, except dust, impurity and non-medicinal part and fully dry;

(2), with the above-mentioned raw materials mix homogeneously, mixture is crushed to 150 orders;

(3), by the ultra-fine grinding technology mixture in (2) is crushed to 30 microns.

(4), said mixture is made powder.

Embodiment 4:

A kind of notoginseng root hematogenic medicament contains following component (kg): Radix Notoginseng 250 processed, Radix Polygoni Multiflori Preparata 250, the Pseudobulbus Bletillae (Rhizoma Bletillae) 150, Radix Rehmanniae Preparata 250, Cornu Cervi Pantotrichum 50, Colla Corii Asini 150, Colla Plastri Testudinis 100, Fructus Mori 50, Semen Cuscutae 150.

Preparation method may further comprise the steps:

(1), the raw material that will choose according to aforementioned proportion, except dust, impurity and non-medicinal part and fully dry;

(2), with the above-mentioned raw materials mix homogeneously, mixture is crushed to 200 orders;

(3), by the ultra-fine grinding technology mixture in (2) is crushed to 200 microns.

(4), said mixture is made electuary.

Embodiment 5:

A kind of notoginseng root hematogenic medicament contains following component (kg): Radix Notoginseng 350 processed, Radix Polygoni Multiflori Preparata 350, the Pseudobulbus Bletillae (Rhizoma Bletillae) 250, Radix Rehmanniae Preparata 350, Cornu Cervi Pantotrichum 150, Colla Corii Asini 250, Colla Plastri Testudinis 200, Fructus Mori 150, Semen Cuscutae 250.

Preparation method may further comprise the steps:

(1), the raw material that will choose according to aforementioned proportion, except dust, impurity and non-medicinal part and fully dry;

(2), with the above-mentioned raw materials mix homogeneously, mixture is crushed to 1000 orders;

(3), by the ultra-fine grinding technology mixture in (2) is crushed to 50 microns.

(4), said mixture is made pill.

Claims (7)

1. notoginseng root hematogenic medicament is formed by the Chinese drug preparation of following weight portion: Radix Notoginseng 250-350 processed, Radix Polygoni Multiflori Preparata 250-350, Pseudobulbus Bletillae (Rhizoma Bletillae) 150-250, Radix Rehmanniae Preparata 250-350, Cornu Cervi Pantotrichum 50-150, Colla Corii Asini 150-250, Colla Plastri Testudinis 100-200, Fructus Mori 50-150, Semen Cuscutae 150-250.

2. notoginseng root hematogenic medicament according to claim 1, described Chinese medicine weight portion is: Radix Notoginseng 300 processed, Radix Polygoni Multiflori Preparata 300, the Pseudobulbus Bletillae (Rhizoma Bletillae) 200, Radix Rehmanniae Preparata 300, Cornu Cervi Pantotrichum 100, Colla Corii Asini 200, Colla Plastri Testudinis 150, Fructus Mori 100, Semen Cuscutae 200.

3. notoginseng root hematogenic medicament as claimed in claim 1 or 2, described medicine is made capsule, powder, electuary or pill.

4. notoginseng root hematogenic medicament is formed by the Chinese drug preparation of following weight portion: Radix Notoginseng 270-325 processed, Radix Polygoni Multiflori Preparata 275-320, Pseudobulbus Bletillae (Rhizoma Bletillae) 175-230, Radix Rehmanniae Preparata 270-320, Cornu Cervi Pantotrichum 80-125, Colla Corii Asini 180-225, Colla Plastri Testudinis 80-175, Fructus Mori 75-120, Semen Cuscutae 180-230.

5. preparation method such as claim 1,2 or 4 described notoginseng root hematogenic medicaments may further comprise the steps:

(1), the raw material that will choose according to aforementioned proportion, except dust, impurity and non-medicinal part and fully dry;

(2), with the above-mentioned raw materials mix homogeneously, mixture is crushed to the 100-200 order;

(3), by the ultra-fine grinding technology mixture in (2) is crushed to the 20-50 micron.

6. mixture becomes capsule with zero number medical capsule fill in the preparation method of notoginseng root hematogenic medicament as claimed in claim 5, described step (3).

7. the preparation method of notoginseng root hematogenic medicament as claimed in claim 5, described step (3) mixture is made powder, electuary or pill.