CN101618132A - Chinese medicinal herb for treating aplastic anemia - Google Patents

Abstract

The invention discloses a Chinese medicinal herb for treating aplastic anemia, which is prepared from membranous milkvetch root, codonopsis pilosula, red ginseng, cooked rehmannia root, suberect spatholobus stem, largehead atractylodes rhizome, cassia bark, tangerine peel, cinnamomvine, malaytea scurfpea fruit, barbed skullcap herb and medlar in certain proportion by weight. The Chinese medicinal herb effectively treats the aplastic anemia by specifically starting from the spleen and the kidney, adopting a method of nourishing qi and blood and yin and yang and using the synergism played between active ingredients of medicaments, and has the advantages of obvious curative effect and shorter treatment course.

Description

A kind of Chinese herbal medicine for the treatment of aplastic anemia

Technical field

The invention belongs to tcm field, relate to a kind of Chinese herbal medicine, be specifically related to a kind of Chinese herbal medicine for the treatment of aplastic anemia, and its processing technology is studied.

Technical background

Anemia is meant that red blood cell mass is reduced to below the normal value in the systemic circulation blood.Wherein with achlorhydria and columna lateralis medullae spinalis, rear pillar atrophy, the course of disease is slow, and the anemia that hematopoietic disorder causes is called aplastic anemia.

Investigate through some areas in China, per 100,000 philtrums have 1.87～2.1 people morbidity, and the sickness rate of reporting with Japan is close.Each age group all can be fallen ill, but sees with person between twenty and fifty more, and the male is more than the women.The ratio of acute and chronic type case is 1: 4.6.Aplastic anemia seemingly belongs to the category that Chinese medicine " asthenia ", " deficient " reach " blood disorder ".Thought incurable disease in the past,, took on a new look its prognosis is existing through the practice of therapy of combining Chinese and Western medicine over more than 40 years.According to investigations, the mean age at death prolongs, and case fatality rate descends, and prevalence increases.

Aplastic anemia is to be changed by bone marrow stem cell, hematopoieticmicroenviron-ment damage and immunologic mechanism that multiple reason causes, causes marrow hematopoiesis function failure, the disease of main performance occurs being reduced to complete blood cell (erythrocyte, granulocyte, platelet).The pathological change of aplastic anemia is mainly the fatization of red bone marrow, and that is to say has the red bone marrow of hemopoietic function to be replaced by fat originally, and the big more then anemia of the quantity of replacement is serious more.Aplastic anemia is clinical mainly to show as carrying out property anemia, hemorrhage and infect (heat occurs together).According to its clinical onset situation, the course of disease, the state of an illness, the order of severity, routine blood test, bone marrow smear with lapse to and be divided into acute aplastic anemia and chronic aplastic anemia.

Acute aplastic anemia is more common in the child.Onset is anxious, and majority has clear and definite date of the onset.Clear and definite inducement is often arranged before the onset.Show as serious hemorrhage and infection when examining.Anemia is not obvious during onset, but along with carrying out property anemia appears in the prolongation of the course of disease; Onset is former because infect, and heating accounts for the overwhelming majority; Hemorrhage skin and the mucosa of being shows as dermatorrhagia point, large stretch of ecchymosis, oral cavity bleeding blister, gingiva bleeding gingival hemorrhage, retinal hemorrhage etc., and intracranial hemorrhage can appear in about half patient.Prognosis is not good.

The chronic aplastic anemia adult is more than the child.Onset is slow, how to fall ill with anemia.Anemia is chronic process.The concurrent infection person is less; See that with dermatorrhagia point prognosis is better more.

Summary of the invention

The object of the invention is to provide a kind of Chinese herbal medicine for the treatment of aplastic anemia, comprises its raw material prescription and processing technology.

Be achieved through the following technical solutions order of the present invention:

1, the present invention is the Chinese herbal medicine of being made by the following weight proportion raw material:

Radix Astragali 41-89 part Radix Codonopsis 31-79 part Radix Ginseng Rubra 11-59 part

Radix Rehmanniae Preparata 31-79 part Caulis Spatholobi 41-89 part Rhizoma Atractylodis Macrocephalae 21-69 part

Cortex Cinnamomi 21-69 part Pericarpium Citri Reticulatae 41-89 part Rhizoma Dioscoreae 21-69 part

Fructus Psoraleae 31-79 part Herba Scutellariae Barbatae 11-59 part Fructus Lycii 11-59 part

2, best each the raw material weight proportioning of prescription of the present invention is:

49 parts of 61 parts of Radix Ginseng Rubra of 71 parts of Radix Codonopsis of the Radix Astragali

59 parts of 71 parts of Rhizoma Atractylodis Macrocephalaes of 61 portions of Caulis Spatholobis of Radix Rehmanniae Preparata

59 parts of 71 portions of Rhizoma Dioscoreaes of 59 parts of Pericarpium Citri Reticulataes of Cortex Cinnamomi

49 parts of 49 parts of Fructus Lycii of 61 portions of Herba Scutellariae Barbataes of Fructus Psoraleae

3, its processing technology is as follows:

(1) get Cortex Cinnamomi, Pericarpium Citri Reticulatae, mixed extraction volatile oil, it is standby to collect volatile oil;

(2) with Radix Codonopsis, Radix Ginseng Rubra, the Rhizoma Atractylodis Macrocephalae, Herba Scutellariae Barbatae, with 70～90% alcohol reflux 3～5 times, extracted 1～2 hour at every turn, collect alcohol extract, gradation is filtered, and merging filtrate, decompression filtrate recycling ethanol make it contain the alcohol amount to be about 50%, and be standby;

(3) medicinal residues and Six-elements such as all the other Radixs Astragali, Radix Rehmanniae Preparata after getting volatile oil and extracting mix, and the water of 8～12 times of medical material amounts of adding decocts 2～4 times, the each decoction 1 hour filtered respectively, merging filtrate, and filtrate is concentrated in right amount, put coldly, add ethanol and make the alcohol amount of containing reach about 50%, leave standstill.Get supernatant, with processing step (2) gained 50% alcohol extract, mix, reclaim under reduced pressure continues to be concentrated into thick paste to there not being the alcohol flavor, puts to be chilled to room temperature and to get paste, and is standby;

(4) will spray into the volatile oil of Cortex Cinnamomi, Pericarpium Citri Reticulatae after the paste dried, mixing, fill becomes capsule; Or in paste, add an amount of dextrin or starch or other drug excipient, make soft material, then soft material is sieved, dry, put cold, as to spray into Cortex Cinnamomi, Pericarpium Citri Reticulatae volatile oil, mixing is made electuary or is pressed into tablet, promptly gets Chinese herbal medicine of the present invention.

The invention discloses a kind of Chinese herbal medicine for the treatment of aplastic anemia.This Chinese herbal medicine is formulated by a certain percentage of the weight by the Radix Astragali, Radix Codonopsis, Radix Ginseng Rubra, Radix Rehmanniae Preparata, Caulis Spatholobi, the Rhizoma Atractylodis Macrocephalae, Cortex Cinnamomi, Pericarpium Citri Reticulatae, Rhizoma Dioscoreae, Fructus Psoraleae, Herba Scutellariae Barbatae, Fructus Lycii.Specifically be to take from spleen affection of the kidney by cold-dampness hands, the maneuver of QI and blood, tonifying both YIN and YANG is utilized between each effective ingredient and is brought into play synergism, thereby effectively treats aplastic anemia, and it is evident in efficacy, and the course of treatment is shorter.

The specific embodiment of form is described in further detail foregoing of the present invention by the following examples.Following example is based on the above-mentioned subject area of the present invention, but is not limited to following example.

The specific embodiment

Embodiment 1: a kind of capsule for the treatment of aplastic anemia

Adopt following raw material prescription:

Radix Astragali 71g Radix Codonopsis 61g Radix Ginseng Rubra 49g

Radix Rehmanniae Preparata 61g Caulis Spatholobi 71g Rhizoma Atractylodis Macrocephalae 59g

Cortex Cinnamomi 59g Pericarpium Citri Reticulatae 71g Rhizoma Dioscoreae 59g

Fructus Psoraleae 61g Herba Scutellariae Barbatae 49g Fructus Lycii 49g

Its processing technology is as follows:

(1) get Cortex Cinnamomi 59g, Pericarpium Citri Reticulatae 71g, mixed extraction volatile oil, it is standby to collect volatile oil;

(2) with Radix Codonopsis, Radix Ginseng Rubra, the Rhizoma Atractylodis Macrocephalae, Herba Scutellariae Barbatae, with 85% alcohol reflux 4 times, extracted 1 hour at every turn, collect alcohol extract, gradation is filtered, and merging filtrate, decompression filtrate recycling ethanol make it contain the alcohol amount to be about 50%, and be standby;

(3) medicinal residues and Six-elements such as all the other Radixs Astragali, Radix Rehmanniae Preparata after getting volatile oil and extracting mix, and the water of 10 times of medical material amounts of adding decocts 3 times, the each decoction 1 hour filtered respectively, merging filtrate, and filtrate is concentrated in right amount, put coldly, add ethanol and make the alcohol amount of containing reach about 50%, leave standstill.Get supernatant, with processing step (2) gained 50% alcohol extract, mix, reclaim under reduced pressure continues to be concentrated into thick paste to there not being the alcohol flavor, puts to be chilled to room temperature and to get paste, and is standby;

(4) volatile oil of Cortex Cinnamomi, Pericarpium Citri Reticulatae will be sprayed into after the paste dried, mixing, the encapsulated capsule that promptly gets.

Embodiment 2: a kind of electuary for the treatment of aplastic anemia

Adopt following raw material prescription:

Radix Astragali 41g Radix Codonopsis 31g Radix Ginseng Rubra 11g

Radix Rehmanniae Preparata 31g Caulis Spatholobi 41g Rhizoma Atractylodis Macrocephalae 21g

Cortex Cinnamomi 21g Pericarpium Citri Reticulatae 41g Rhizoma Dioscoreae 21g

Fructus Psoraleae 31g Herba Scutellariae Barbatae 11g Fructus Lycii 11g

Its processing technology is as follows:

(1) get Cortex Cinnamomi 21g, Pericarpium Citri Reticulatae 41g, mixed extraction volatile oil, it is standby to collect volatile oil;

(2) with Radix Codonopsis 31g, Radix Ginseng Rubra 11g, Rhizoma Atractylodis Macrocephalae 21g, Herba Scutellariae Barbatae 11g, with 70% alcohol reflux 3 times, extracted 1 hour at every turn, collect alcohol extract, gradation is filtered, and merging filtrate, decompression filtrate recycling ethanol make it contain the alcohol amount to be about 50%, and be standby;

(3) medicinal residues and Six-elements such as all the other Radixs Astragali, Radix Rehmanniae Preparata after getting volatile oil and extracting mix, and the water of 8 times of medical material amounts of adding decocts 2 times, the each decoction 1 hour filtered respectively, merging filtrate, and filtrate is concentrated in right amount, put coldly, add ethanol and make the alcohol amount of containing reach about 50%, leave standstill.Get supernatant, with processing step (2) gained 50% alcohol extract, mix, reclaim under reduced pressure continues to be concentrated into thick paste to there not being the alcohol flavor, puts to be chilled to room temperature and to get paste, and is standby;

(4) in paste, add appropriate amount of starch and cane sugar powder, drying, put cold, the operation of pulverizing, sieve after, spray into the volatile oil of Cortex Cinnamomi, Pericarpium Citri Reticulatae, mixing is granulated, and makes electuary.

Embodiment 3: a kind of tablet for the treatment of aplastic anemia

Adopt following raw material prescription:

Radix Astragali 89g Radix Codonopsis 79g joins 59g

Radix Rehmanniae Preparata 79g Caulis Spatholobi 89g Rhizoma Atractylodis Macrocephalae 69g

Cortex Cinnamomi 69g Pericarpium Citri Reticulatae 89g Rhizoma Dioscoreae 69g

Fructus Psoraleae 79g Herba Scutellariae Barbatae 59g Fructus Lycii 59g

Its processing technology is as follows:

(1) get Cortex Cinnamomi 69g, Pericarpium Citri Reticulatae 89g, mixed extraction volatile oil, it is standby to collect volatile oil;

(2) with Radix Codonopsis 79g, Radix Ginseng Rubra 59g, Rhizoma Atractylodis Macrocephalae 69g, Herba Scutellariae Barbatae 59g, with 80% alcohol reflux 4 times, extracted 1 hour at every turn, collect alcohol extract, gradation is filtered, and merging filtrate, decompression filtrate recycling ethanol make it contain the alcohol amount to be about 50%, and be standby;

(3) medicinal residues and Six-elements such as all the other Radixs Astragali, Radix Rehmanniae Preparata after getting volatile oil and extracting mix, and the water of 12 times of medical material amounts of adding decocts 4 times, the each decoction 1 hour filtered respectively, merging filtrate, and filtrate is concentrated in right amount, put coldly, add ethanol and make the alcohol amount of containing reach about 50%, leave standstill.Get supernatant, with processing step (2) gained 50% alcohol extract, mix, reclaim under reduced pressure continues to be concentrated into thick paste to there not being the alcohol flavor, puts to be chilled to room temperature and to get paste, and is standby;

(4) it is an amount of to add starch in paste, mixing, cold drying, pulverize fine powder, put coldly, sieve, add 3% magnesium stearate again, spray into the volatile oil of Cortex Cinnamomi, Pericarpium Citri Reticulatae, mixing, compacting in flakes, promptly.

Claims (3)

1, a kind of Chinese herbal medicine for the treatment of aplastic anemia is characterized in that it comprises what unit of weight was made by the following raw material of part:

Radix Astragali 41-89 part Radix Codonopsis 31-79 part Radix Ginseng Rubra 11-59 part

Radix Rehmanniae Preparata 31-79 part Caulis Spatholobi 41-89 part Rhizoma Atractylodis Macrocephalae 21-69 part

Cortex Cinnamomi 21-69 part Pericarpium Citri Reticulatae 41-89 part Rhizoma Dioscoreae 21-69 part

Fructus Psoraleae 31-79 part Herba Scutellariae Barbatae 11-59 part Fructus Lycii 11-59 part.

2, a kind of Chinese herbal medicine for the treatment of aplastic anemia as claimed in claim 1 is characterized in that the weight proportion of each component is:

49 parts of 61 parts of Radix Ginseng Rubra of 71 parts of Radix Codonopsis of the Radix Astragali

59 parts of 71 parts of Rhizoma Atractylodis Macrocephalaes of 61 portions of Caulis Spatholobis of Radix Rehmanniae Preparata

59 parts of 71 portions of Rhizoma Dioscoreaes of 59 parts of Pericarpium Citri Reticulataes of Cortex Cinnamomi

49 parts of 49 parts of Fructus Lycii of 61 portions of Herba Scutellariae Barbataes of Fructus Psoraleae.

3, as the described a kind of Chinese herbal medicine for the treatment of aplastic anemia of claim 1-2, it is characterized in that the processing technology of this Chinese herbal medicine is as follows:

(1) get Cortex Cinnamomi, Pericarpium Citri Reticulatae, mixed extraction volatile oil, it is standby to collect volatile oil;

(2) with Radix Codonopsis, Radix Ginseng Rubra, the Rhizoma Atractylodis Macrocephalae, Herba Scutellariae Barbatae, with 70～90% alcohol reflux 3～5 times, extracted 1～2 hour at every turn, collect alcohol extract, gradation is filtered, and merging filtrate, decompression filtrate recycling ethanol make it contain the alcohol amount to be about 50%, and be standby;

(3) medicinal residues and Six-elements such as all the other Radixs Astragali, Radix Rehmanniae Preparata after getting volatile oil and extracting mix, and the water of 8～12 times of medical material amounts of adding decocts 2～4 times, the each decoction 1 hour filtered respectively, merging filtrate, and filtrate is concentrated in right amount, put coldly, add ethanol and make the alcohol amount of containing reach about 50%, leave standstill.Get supernatant, with processing step (2) gained 50% alcohol extract, mix, reclaim under reduced pressure continues to be concentrated into thick paste to there not being the alcohol flavor, puts to be chilled to room temperature and to get paste, and is standby;

(4) will spray into the volatile oil of Cortex Cinnamomi, Pericarpium Citri Reticulatae after the paste dried, mixing, fill becomes capsule; Or in paste, add an amount of dextrin or starch or other drug excipient, make soft material, then soft material is sieved, dry, put cold, as to spray into Cortex Cinnamomi, Pericarpium Citri Reticulatae volatile oil, mixing is made electuary or is pressed into tablet, promptly gets Chinese herbal medicine of the present invention.