CN104288579A - Traditional Chinese medicine for treating chronic nephritis and preparation method thereof - Google Patents

Traditional Chinese medicine for treating chronic nephritis and preparation method thereof Download PDF

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CN104288579A
CN104288579A CN201410595087.1A CN201410595087A CN104288579A CN 104288579 A CN104288579 A CN 104288579A CN 201410595087 A CN201410595087 A CN 201410595087A CN 104288579 A CN104288579 A CN 104288579A
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赵士启
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Abstract

The invention discloses a traditional Chinese medicine for treating chronic nephritis and a preparation method thereof, and belongs to the technical field of medicine. The traditional Chinese medicine is prepared from the following raw materials: astragalus membranaceus, angelica sinensis, pseudo-ginseng, radix codonopsis, cornus officinalis, poria cocos, lalang grass rhizome, folium pyrrosiae, fructus psoraleae, herba houttuyniae, Chinese wolfberries, cassia twig, schisandra chinensis, citrus aurantium, squama manitis, glycyrrhiza uralensis fisch, rhizoma alismatis and medicated leaven. According to the traditional Chinese medicine provided by the invention, different Chinese herbs in the formula are combined to enable the traditional Chinese medicine to have the effects of tonifying qi, nourishing blood, promoting blood circulation to remove blood stasis, tonifying the kidney, resolving dampness, inducing diuresis to alleviate edema, nourishing liver and kidney, and raising yang and nourishing spleen, due to the medical synergistic effect, lesions can be directly eliminated and the effects of treating both symptoms and root causes are achieved.

Description

A kind of Chinese medicine being used for the treatment of chronic nephritis and preparation method thereof
Technical field
The present invention relates to medical art, particularly relate to a kind of Chinese medicine being used for the treatment of chronic nephritis and preparation method thereof.
Background technology
Chronic nephritis is a kind of systemic disease based on nephropathy, clinical with edema, albuminuria for primary symptom, with renal hypofunction in various degree, normal recurrent exerbation, delay difficulty more, can there are anemia, retinopathy and uremia etc. in the later stage, even threat to life.Chronic nephritis belongs to one of worldwide difficult treatment, and patient mostly is between twenty and fifty, and according to incompletely statistics, the prevalence of the chronic nephritis of China is about 1-2%.In recent years, the sickness rate of chronic nephritis also has the trend constantly raised.The treatment doctor trained in Western medicine of current chronic nephritis is symptomatic treatment, as blood pressure lowering, infection, diuresis, keeps on a diet, there is obvious limitation.
Chronic nephritis belongs to the category of the traditional Chinese medical science " edema ", " lumbago ", " asthenia ", " hematuria ".Based on deficiency in origin, holding concurrently, folder water is wet, damp and hot, congestion, expectorant are turbid.Strengthening vital QI to eliminate pathogenic factors, giving consideration to both the incidental and fundamental are answered in treatment.Wherein blood stasis is the major reason that pathological changes sustainable development and renal function Progressive symmetric erythrokeratodermia go down, and noxious dampness is the basic pathology factor of primary disease.
China's traditional medicine had many discussions and therapeutic scheme to chronic nephritis since ancient times.The medicine typing of chronic nephritis has been formulated in Second National Chinese Medical Nephrosis in 1986 academic conference, and namely this disease has insufficiency of QI of the lung and kidney, deficiency of spleen-YANG and kidneyYANG, the hepatic and renal YIN deficiency, QI and blood deficiency; Mark disease has that diseases caused by exogenous pathogenic factor, water are wet, damp and hot, blood stasis, turbid damp.Chronic nephritis is touching for the course for the treatment of, healthy energy rapid wear, therefore person is many to present in deficiency in origin, and because of prolonged illness consumption gas, the deficiency of vital energy is difficult hemopoietic, and blood deficiency is difficult to moisten gas, easily causes qi-blood deficiency syndrome and is formed.The chronic nephritis state of an illness is complicated and changeable, and deficiency in origin and the domination of pathogen are held concurrently mutually as suffering from.Wherein qi-blood deficiency syndrome type, the disease of folder congestion resistance network of holding concurrently, it is because coming from, qi as the commander of blood, the reason of blood circulation depending on qi flow more.The prolonged illness deficiency of vital energy, drum fortune is unable, hematogenous blockage, and with the passing of time blood vessels hinder for it and freeze, therefore works as the treatment of chronic nephritis based on the medicine of benefiting QI and nourishing blood, blood circulation promoting and blood stasis dispelling.
Summary of the invention
In order to solve current chronic nephritis treatment situation be not very desirable problem, the invention provides a kind of Chinese medicine being used for the treatment of chronic nephritis and preparation method thereof.
The technical scheme that the present invention takes is:
The Chinese medicine that the present invention is used for the treatment of chronic nephritis is made up of the raw material of following weight portion: Radix Astragali 80-160 part, Radix Angelicae Sinensis 90-170 part, Radix Notoginseng 80-150 part, Radix Codonopsis 70-140 part, Fructus Corni 60-130 part, Poria 100-200 part, Rhizoma Imperatae 50-110 part, Folium Pyrrosiae 50-120 part, Fructus Psoraleae 40-100 part, Herba Houttuyniae 70-100 part, Fructus Lycii 60-120 part, Ramulus Cinnamomi 30-70 part, Fructus Schisandrae Chinensis 40-90 part, Fructus Aurantii Immaturus 30-80 part, Squama Manis 50-100 part, Radix Glycyrrhizae 20-50 part, Rhizoma Alismatis 10-40 part, Massa Medicata Fermentata 10-30 part.
As one of preferred technical scheme: Chinese medicine of the present invention is made up of the raw material of following weight portion: the Radix Astragali 80 parts, Radix Angelicae Sinensis 170 parts, Radix Notoginseng 80 parts, Radix Codonopsis 140 parts, Fructus Corni 60 parts, 200 parts, Poria, Rhizoma Imperatae 50 parts, Folium Pyrrosiae 120 parts, Fructus Psoraleae 40 parts, Herba Houttuyniae 100 parts, Fructus Lycii 60 parts, Ramulus Cinnamomi 70 parts, Fructus Schisandrae Chinensis 40 parts, Fructus Aurantii Immaturus 80 parts, Squama Manis 50 parts, 50 parts, Radix Glycyrrhizae, Rhizoma Alismatis 10 parts, Massa Medicata Fermentata 30 parts.
As preferred technical scheme two: Chinese medicine of the present invention is made up of the raw material of following weight portion: the Radix Astragali 160 parts, Radix Angelicae Sinensis 90 parts, Radix Notoginseng 150 parts, Radix Codonopsis 70 parts, Fructus Corni 130 parts, 100 parts, Poria, Rhizoma Imperatae 110 parts, Folium Pyrrosiae 50 parts, Fructus Psoraleae 100 parts, Herba Houttuyniae 70 parts, Fructus Lycii 120 parts, Ramulus Cinnamomi 30 parts, Fructus Schisandrae Chinensis 90 parts, Fructus Aurantii Immaturus 30 parts, Squama Manis 100 parts, 20 parts, Radix Glycyrrhizae, Rhizoma Alismatis 40 parts, Massa Medicata Fermentata 10 parts.
As preferred technical scheme three: Chinese medicine of the present invention is made up of the raw material of following weight portion: the Radix Astragali 110 parts, Radix Angelicae Sinensis 130 parts, Radix Notoginseng 120 parts, Radix Codonopsis 100 parts, Fructus Corni 90 parts, 150 parts, Poria, Rhizoma Imperatae 80 parts, Folium Pyrrosiae 90 parts, Fructus Psoraleae 70 parts, Herba Houttuyniae 80 parts, Fructus Lycii 90 parts, Ramulus Cinnamomi 50 parts, Fructus Schisandrae Chinensis 60 parts, Fructus Aurantii Immaturus 50 parts, Squama Manis 70 parts, 30 parts, Radix Glycyrrhizae, Rhizoma Alismatis 30 parts, Massa Medicata Fermentata 20 parts.
The preparation method that the present invention is used for the treatment of the Chinese medicine of chronic nephritis is specific as follows:
(1) first take traditional Chinese medicinal material raw materials by proportioning, pulverize respectively, cross 100 mesh sieves, obtain drug powder;
(2) drug powder of the Radix Astragali, Radix Angelicae Sinensis, Radix Notoginseng, Radix Codonopsis, Fructus Corni, Poria, Ramulus Cinnamomi, Fructus Schisandrae Chinensis, Fructus Aurantii Immaturus and Squama Manis is mixed, add in decoction pot, decoct with water twice, amount of water is 8-13 times of medical material weight for the first time, and decocting time is 2-5h, and second time amount of water is 5-10 times of medical material weight, decocting time is 1-3h, merge decoction liquor, filter, obtain filtrate;
(3) drug powder of Rhizoma Imperatae, Folium Pyrrosiae, Fructus Psoraleae, Herba Houttuyniae, Fructus Lycii, Radix Glycyrrhizae, Rhizoma Alismatis and Massa Medicata Fermentata is mixed, add in decoction pot, add dehydrated alcohol extraction twice, dehydrated alcohol addition is 5-9 times of medical material weight for the first time, and decocting time is 2-5h, and second time dehydrated alcohol addition is 2-6 times of medical material weight, decocting time is 1-3h, merge decoction liquor, filter, obtain filtrate;
(4) filtrate of combining step (2) and step (3), then filtrate carrying out is revolved steaming, removing dehydrated alcohol, then it is concentrated to carry out heating to filtrate, being condensed into relative density at 60 DEG C is the clear paste of 1.08-1.13, then makes granule, capsule or tablet according to a conventional method.
In step (2), preferably first time 11 times of adding water as medical material weight, decocting time is 4h, and second time amount of water is 8 times of medical material weight, and decocting time is 2h.
In step (3), preferably dehydrated alcohol addition is 7 times of medical material weight for the first time, and decocting time is 4h, and second time dehydrated alcohol addition is 4 times of medical material weight, and decocting time is 2h.
In step (3), preferably carry out heating to filtrate and concentrate, being condensed into relative density at 60 DEG C is the clear paste of 1.10.
The present invention, on the basis of differential diagnosis in tcm, according to the principles of formulating prescriptions of traditional Chinese medical science monarch, chooses the Radix Astragali, Radix Angelicae Sinensis, Radix Notoginseng, Radix Codonopsis, Fructus Corni, Poria as monarch drug; The Radix Astragali have protect the liver, diuresis, defying age, anti-stress, blood pressure lowering effect; Radix Angelicae Sinensis has the effect of enriching blood, invigorating blood circulation; Radix Notoginseng has hemostasis, dissipating blood stasis, effect of detumescence, analgesic therapy; Radix Codonopsis has invigorating middle warmer, QI invigorating, the effect of promoting the production of body fluid; Fructus Corni has liver and kidney tonifying, the solid de-effect of convergence; Poria has effect of eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming.
Choose Rhizoma Imperatae, Folium Pyrrosiae, Fructus Psoraleae, Herba Houttuyniae, Fructus Lycii be ministerial drug; Rhizoma Imperatae has effect of cooling blood for hemostasis, heat-clearing and toxic substances removing; Effect that Folium Pyrrosiae has relieving stranguria by diuresis, lung heat clearing expels the heat-evil; Fructus Psoraleae has effect of kidney invigorating and YANG supporting, spleen reinforcing stomach invigorating; Effect that Herba Houttuyniae has heat-clearing and toxic substances removing, skin ulcer, promoting urination to remove dampness, clearing away heat to cure dysentery are treated in detumescence; Fructus Lycii has nourishing the liver, nourishing kidney, effect of lung moistening.
Choose Ramulus Cinnamomi, Fructus Schisandrae Chinensis, Fructus Aurantii Immaturus, Squama Manis be adjuvant drug; Ramulus Cinnamomi has effect of complement sun, promoting blood circulation, warming the spleen and stomach; Fructus Schisandrae Chinensis have astringe the lung, nourishing kidney, promote the production of body fluid, receive antiperspirant, arresting seminal emission effect; Fructus Aurantii Immaturus have control painful abdominal mass, help digestion, effect of stomach strengthening; Hard effect that Squama Manis has blood circulation promoting and dispersing pathogen accumulation, eliminating carbuncle is burst.
Choose Radix Glycyrrhizae, Rhizoma Alismatis, Massa Medicata Fermentata for making medicine; Radix Glycyrrhizae has effect of heat-clearing and toxic substances removing, antiinflammatory; Rhizoma Alismatis has diuretic, eliminating dampness by diuresis, effect of expelling the heat-evil; Effect that Massa Medicata Fermentata has regulating QI to expel dampness, induces sweat.
In formula of the present invention, all medicines share, and have effect of benefiting QI and nourishing blood, blood circulation promoting and blood stasis dispelling, kidney tonifying removing dampness, inducing diuresis to remove edema, nourishing the liver and kidney, yang invigorating spleen reinforcing, its drug effect synergism, and the efficacy of a drug is gone directly focus, reaches the effect for the treatment of both the principal and secondary aspects of a disease.
Detailed description of the invention
The following examples describe in further detail of the present invention.
Embodiment 1
Raw material composition (g):
The Radix Astragali 80, Radix Angelicae Sinensis 170, Radix Notoginseng 80, Radix Codonopsis 140, Fructus Corni 60, Poria 200, Rhizoma Imperatae 50, Folium Pyrrosiae 120, Fructus Psoraleae 40, Herba Houttuyniae 100, Fructus Lycii 60, Ramulus Cinnamomi 70, Fructus Schisandrae Chinensis 40, Fructus Aurantii Immaturus 80, Squama Manis 50, Radix Glycyrrhizae 50, Rhizoma Alismatis 10, Massa Medicata Fermentata 30.
Preparation method:
(1) first take traditional Chinese medicinal material raw materials by proportioning, pulverize respectively, cross 100 mesh sieves, obtain drug powder;
(2) drug powder of the Radix Astragali, Radix Angelicae Sinensis, Radix Notoginseng, Radix Codonopsis, Fructus Corni, Poria, Ramulus Cinnamomi, Fructus Schisandrae Chinensis, Fructus Aurantii Immaturus and Squama Manis is mixed, add in decoction pot, decoct with water twice, amount of water is 8 times of medical material weight for the first time, and decocting time is 2h, and second time amount of water is 5 times of medical material weight, decocting time is 1h, merge decoction liquor, filter, obtain filtrate;
(3) drug powder of Rhizoma Imperatae, Folium Pyrrosiae, Fructus Psoraleae, Herba Houttuyniae, Fructus Lycii, Radix Glycyrrhizae, Rhizoma Alismatis and Massa Medicata Fermentata is mixed, add in decoction pot, add dehydrated alcohol extraction twice, dehydrated alcohol addition is 5 times of medical material weight for the first time, and decocting time is 2h, and second time dehydrated alcohol addition is 2 times of medical material weight, decocting time is 1h, merge decoction liquor, filter, obtain filtrate;
(4) filtrate of combining step (2) and step (3), then revolves steaming by filtrate carrying out, removing dehydrated alcohol, then it is concentrated to carry out heating to filtrate, and being condensed into relative density at 60 DEG C is the clear paste of 1.08, then makes tablet according to a conventional method.
Embodiment 2
Raw material composition (g):
The Radix Astragali 160, Radix Angelicae Sinensis 90, Radix Notoginseng 150, Radix Codonopsis 70, Fructus Corni 130, Poria 100, Rhizoma Imperatae 110, Folium Pyrrosiae 50, Fructus Psoraleae 100, Herba Houttuyniae 70, Fructus Lycii 120, Ramulus Cinnamomi 30, Fructus Schisandrae Chinensis 90, Fructus Aurantii Immaturus 30, Squama Manis 100, Radix Glycyrrhizae 20, Rhizoma Alismatis 40, Massa Medicata Fermentata 10.
Preparation method:
(1) first take traditional Chinese medicinal material raw materials by proportioning, pulverize respectively, cross 100 mesh sieves, obtain drug powder;
(2) drug powder of the Radix Astragali, Radix Angelicae Sinensis, Radix Notoginseng, Radix Codonopsis, Fructus Corni, Poria, Ramulus Cinnamomi, Fructus Schisandrae Chinensis, Fructus Aurantii Immaturus and Squama Manis is mixed, add in decoction pot, decoct with water twice, amount of water is 13 times of medical material weight for the first time, and decocting time is 5h, and second time amount of water is 10 times of medical material weight, decocting time is 3h, merge decoction liquor, filter, obtain filtrate;
(3) drug powder of Rhizoma Imperatae, Folium Pyrrosiae, Fructus Psoraleae, Herba Houttuyniae, Fructus Lycii, Radix Glycyrrhizae, Rhizoma Alismatis and Massa Medicata Fermentata is mixed, add in decoction pot, add dehydrated alcohol extraction twice, dehydrated alcohol addition is 9 times of medical material weight for the first time, and decocting time is 5h, and second time dehydrated alcohol addition is 6 times of medical material weight, decocting time is 3h, merge decoction liquor, filter, obtain filtrate;
(4) filtrate of combining step (2) and step (3), then revolves steaming by filtrate carrying out, removing dehydrated alcohol, then it is concentrated to carry out heating to filtrate, and being condensed into relative density at 60 DEG C is the clear paste of 1.13, then makes capsule according to a conventional method.
Embodiment 3
Raw material composition (g):
The Radix Astragali 110, Radix Angelicae Sinensis 130, Radix Notoginseng 120, Radix Codonopsis 100, Fructus Corni 90, Poria 150, Rhizoma Imperatae 80, Folium Pyrrosiae 90, Fructus Psoraleae 70, Herba Houttuyniae 80, Fructus Lycii 90, Ramulus Cinnamomi 50, Fructus Schisandrae Chinensis 60, Fructus Aurantii Immaturus 50, Squama Manis 70, Radix Glycyrrhizae 30, Rhizoma Alismatis 30, Massa Medicata Fermentata 20.
Preparation method:
(1) first take traditional Chinese medicinal material raw materials by proportioning, pulverize respectively, cross 100 mesh sieves, obtain drug powder;
(2) drug powder of the Radix Astragali, Radix Angelicae Sinensis, Radix Notoginseng, Radix Codonopsis, Fructus Corni, Poria, Ramulus Cinnamomi, Fructus Schisandrae Chinensis, Fructus Aurantii Immaturus and Squama Manis is mixed, add in decoction pot, decoct with water twice, amount of water is 11 times of medical material weight for the first time, and decocting time is 4h, and second time amount of water is 8 times of medical material weight, decocting time is 2h, merge decoction liquor, filter, obtain filtrate;
(3) drug powder of Rhizoma Imperatae, Folium Pyrrosiae, Fructus Psoraleae, Herba Houttuyniae, Fructus Lycii, Radix Glycyrrhizae, Rhizoma Alismatis and Massa Medicata Fermentata is mixed, add in decoction pot, add dehydrated alcohol extraction twice, first time, dehydrated alcohol addition was 7 times amount of medical material weight, and decocting time is 4h, and second time dehydrated alcohol addition is 4 times amount of medical material weight, decocting time is 2h, merge decoction liquor, filter, obtain filtrate;
(4) filtrate of combining step (2) and step (3), then revolves steaming by filtrate carrying out, removing dehydrated alcohol, then it is concentrated to carry out heating to filtrate, and being condensed into relative density at 60 DEG C is the clear paste of 1.10, then makes granule according to a conventional method.
Pharmacodynamic study
(1) laboratory animal: Wistar rat, male and female dual-purpose, is provided by China Medical Science academy animal center breeding field.
(2) experimental drug: clear paste prepared by the embodiment of the present invention 3.
(3) experimental technique: first rat is set up Heymann glomerulonephritis animal model, then to injection medicine clear paste of the present invention, divide high, medium and low three dosage, be respectively 0.375,0.75 and 1.5g/kg(amount to crude drug 1,2 and 4g/kg), rat is administered twice every day, successive administration 4 weeks.
(4) experimental result:
Experiment shows: the medicine of three dosage all obviously can increase the body weight of rat, increase average magnitude is 5.3g, and obviously can also reduce twenty-four-hour urine protein content and improve renal function, the serum creatinine of rising and blood urea nitrogen are obviously reduced, and have increasing serum total protein content level, the effect such as blood fat reducing and antioxidation, also can improve hemorheological abnormality and the histological change of Pathological, medicine also presents the dependent immunoregulation effect of obvious function to the thymus of glomerulonephritis rat reduction and the IL-1 level of Spleen coefficient and splenocyte Con A breeder reaction and rising in addition.The above results integrated display, medicine of the present invention has obvious therapeutical effect to rat chronic nephritis.
Clinical efficacy
(1) MethodsThe cases enrolled diagnostic criteria: Western medicine diagnose is the patient of nephritis.
(2) physical data: all selected patients are divided into two groups at random, treatment group 53 example, wherein male patient 32 example, female patient 21 example; Matched group 52 example, wherein male patient 32 example, female patient 20 example.
(3) Therapeutic Method
Matched group prednisone 1-1.5mg/kg every day, oral 6-8 week, then decrement gradually, every 7 days decrement 5mg, oral 10-30mg next day of last, maintain 3 months, suitably use antibiotic, diuretic, persantin.
Treatment group takes granule prepared by the embodiment of the present invention 3 on the basis of matched group, and 10g is each, every day three times.Three months are taken from prednisone decrement.
(4) evaluation of clinical curative effect standard
Recovery from illness: the symptoms such as edema and sign disappear completely, urine protein examination continues negative, and under high power lens, urine erythrocyte disappears, and Urine sediments analyzer counting is normal, normal renal function.
Effective: the symptoms such as edema and sign disappear substantially, urine protein is down to denier, or quantitative 0.5g/24 hour below hr, and under high power field, urine erythrocyte is no more than 3, and Urine sediments analyzer counting is close normal, normal renal function or normal.
Effective: the symptoms such as edema and sign are clearly better, urine protein examination continues to reduce more than (+), and under high power lens, urine erythrocyte is no more than 5, normal renal function or be improved.
Invalid: clinical manifestation and above-mentioned test inspection are all not improved or add severe one.
Total effective rate=(recovery from illness+effective)/total case load × 100%
(5) therapeutic outcome
Two groups of therapeutic outcomes are as shown in table 1.
Table 1 liang group therapeutic effect contrast
The change of two treatment group treatment Plasma Before And After albumin, cholesterol, triglyceride and creatinines is compared in table 2.
The change of Plasma Before And After albumin, cholesterol, triglyceride and creatinine treated by table 2
Note: * P < 0.05 compared with before treatment; * P < 0.01;
Compared with matched group △ p < 0.05; △ △ p < 0.01.
As can be seen from Table 2, treatment group plasma albumin obviously raises (P < 0.01) before comparatively treating, and cholesterol, triglyceride, serum creatinine comparatively treat front (the P < 0.05 that obviously declines, P < 0.01), and significant difference (P < 0.05, P < 0.01) is had compared with matched group.
(6) conclusion
From the above results, medicine of the present invention has good curative effect to chronic nephritis.
Although illustrate and describe embodiments of the invention, for the ordinary skill in the art, be appreciated that and can carry out multiple change, amendment, replacement and modification to these embodiments without departing from the principles and spirit of the present invention, scope of the present invention is by claims and equivalents thereof.

Claims (8)

1. be used for the treatment of a Chinese medicine for chronic nephritis, it is characterized in that being made up of the raw material of following weight portion: Radix Astragali 80-160 part, Radix Angelicae Sinensis 90-170 part, Radix Notoginseng 80-150 part, Radix Codonopsis 70-140 part, Fructus Corni 60-130 part, Poria 100-200 part, Rhizoma Imperatae 50-110 part, Folium Pyrrosiae 50-120 part, Fructus Psoraleae 40-100 part, Herba Houttuyniae 70-100 part, Fructus Lycii 60-120 part, Ramulus Cinnamomi 30-70 part, Fructus Schisandrae Chinensis 40-90 part, Fructus Aurantii Immaturus 30-80 part, Squama Manis 50-100 part, Radix Glycyrrhizae 20-50 part, Rhizoma Alismatis 10-40 part, Massa Medicata Fermentata 10-30 part.
2. be used for the treatment of the Chinese medicine of chronic nephritis as claimed in claim 1, it is characterized in that being made up of the raw material of following weight portion: the Radix Astragali 80 parts, Radix Angelicae Sinensis 170 parts, Radix Notoginseng 80 parts, Radix Codonopsis 140 parts, Fructus Corni 60 parts, 200 parts, Poria, Rhizoma Imperatae 50 parts, Folium Pyrrosiae 120 parts, Fructus Psoraleae 40 parts, Herba Houttuyniae 100 parts, Fructus Lycii 60 parts, Ramulus Cinnamomi 70 parts, Fructus Schisandrae Chinensis 40 parts, Fructus Aurantii Immaturus 80 parts, Squama Manis 50 parts, 50 parts, Radix Glycyrrhizae, Rhizoma Alismatis 10 parts, Massa Medicata Fermentata 30 parts.
3. be used for the treatment of the Chinese medicine of chronic nephritis as claimed in claim 1, it is characterized in that being made up of the raw material of following weight portion: the Radix Astragali 160 parts, Radix Angelicae Sinensis 90 parts, Radix Notoginseng 150 parts, Radix Codonopsis 70 parts, Fructus Corni 130 parts, 100 parts, Poria, Rhizoma Imperatae 110 parts, Folium Pyrrosiae 50 parts, Fructus Psoraleae 100 parts, Herba Houttuyniae 70 parts, Fructus Lycii 120 parts, Ramulus Cinnamomi 30 parts, Fructus Schisandrae Chinensis 90 parts, Fructus Aurantii Immaturus 30 parts, Squama Manis 100 parts, 20 parts, Radix Glycyrrhizae, Rhizoma Alismatis 40 parts, Massa Medicata Fermentata 10 parts.
4. be used for the treatment of the Chinese medicine of chronic nephritis as claimed in claim 1, it is characterized in that being made up of the raw material of following weight portion: the Radix Astragali 110 parts, Radix Angelicae Sinensis 130 parts, Radix Notoginseng 120 parts, Radix Codonopsis 100 parts, Fructus Corni 90 parts, 150 parts, Poria, Rhizoma Imperatae 80 parts, Folium Pyrrosiae 90 parts, Fructus Psoraleae 70 parts, Herba Houttuyniae 80 parts, Fructus Lycii 90 parts, Ramulus Cinnamomi 50 parts, Fructus Schisandrae Chinensis 60 parts, Fructus Aurantii Immaturus 50 parts, Squama Manis 70 parts, 30 parts, Radix Glycyrrhizae, Rhizoma Alismatis 30 parts, Massa Medicata Fermentata 20 parts.
5. prepare a method for the Chinese medicine being used for the treatment of chronic nephritis as described in any one of claim 1-4, it is characterized in that comprising following processing step:
(1) take traditional Chinese medicinal material raw materials by proportioning, pulverize respectively, cross 100 mesh sieves, obtain drug powder;
(2) drug powder of the Radix Astragali, Radix Angelicae Sinensis, Radix Notoginseng, Radix Codonopsis, Fructus Corni, Poria, Ramulus Cinnamomi, Fructus Schisandrae Chinensis, Fructus Aurantii Immaturus and Squama Manis is mixed, add in decoction pot, decoct with water twice, amount of water is 8-13 times of medical material weight for the first time, and decocting time is 2-5h, and second time amount of water is 5-10 times of medical material weight, decocting time is 1-3h, merge decoction liquor, filter, obtain filtrate;
(3) drug powder of Rhizoma Imperatae, Folium Pyrrosiae, Fructus Psoraleae, Herba Houttuyniae, Fructus Lycii, Radix Glycyrrhizae, Rhizoma Alismatis and Massa Medicata Fermentata is mixed, add in decoction pot, add dehydrated alcohol extraction twice, dehydrated alcohol addition is 5-9 times of medical material weight for the first time, and decocting time is 2-5h, and second time dehydrated alcohol addition is 2-6 times of medical material weight, decocting time is 1-3h, merge decoction liquor, filter, obtain filtrate;
(4) filtrate of combining step (2) and step (3), then filtrate carrying out is revolved steaming, removing dehydrated alcohol, then it is concentrated to carry out heating to filtrate, being condensed into relative density at 60 DEG C is the clear paste of 1.08-1.13, then makes granule, capsule or tablet according to a conventional method.
6. as claimed in claim 5 for the preparation of the method for the Chinese medicine for the treatment of chronic nephritis, it is characterized in that: in step (2), amount of water is 11 times of medical material weight for the first time, and decocting time is 4h, second time amount of water is 8 times of medical material weight, and decocting time is 2h.
7. as claimed in claim 5 for the preparation of the method for the Chinese medicine for the treatment of chronic nephritis, it is characterized in that: in step (3), dehydrated alcohol addition is 7 times of medical material weight for the first time, and decocting time is 4h, second time dehydrated alcohol addition is 4 times of medical material weight, and decocting time is 2h.
8. as claimed in claim 5 for the preparation of the method for the Chinese medicine for the treatment of chronic nephritis, it is characterized in that: in step (3), carry out heating to filtrate and concentrate, being condensed into relative density at 60 DEG C is the clear paste of 1.10.
CN201410595087.1A 2014-10-30 2014-10-30 Traditional Chinese medicine for treating chronic nephritis and preparation method thereof Pending CN104288579A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104689216A (en) * 2015-03-30 2015-06-10 刘军芳 Medicine for treating chronic nephritis
CN105106485A (en) * 2015-10-05 2015-12-02 淄博齐鼎立专利信息咨询有限公司 Capsules for treating chronic nephritis

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101850071A (en) * 2009-10-22 2010-10-06 北京绿源求证科技发展有限责任公司 Chinese medicament for treating chronic nephritis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101850071A (en) * 2009-10-22 2010-10-06 北京绿源求证科技发展有限责任公司 Chinese medicament for treating chronic nephritis

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104689216A (en) * 2015-03-30 2015-06-10 刘军芳 Medicine for treating chronic nephritis
CN104689216B (en) * 2015-03-30 2018-02-16 青岛市中心医院 A kind of medicine for treating chronic nephritis
CN105106485A (en) * 2015-10-05 2015-12-02 淄博齐鼎立专利信息咨询有限公司 Capsules for treating chronic nephritis

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