CN109106848A - A kind of Chinese medicine composition and its preparation method and application with lowering blood sugar and preventing thirst - Google Patents
A kind of Chinese medicine composition and its preparation method and application with lowering blood sugar and preventing thirst Download PDFInfo
- Publication number
- CN109106848A CN109106848A CN201811337167.1A CN201811337167A CN109106848A CN 109106848 A CN109106848 A CN 109106848A CN 201811337167 A CN201811337167 A CN 201811337167A CN 109106848 A CN109106848 A CN 109106848A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- medicine composition
- radix
- blood sugar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 90
- 239000000203 mixture Substances 0.000 title claims abstract description 75
- 210000004369 blood Anatomy 0.000 title claims abstract description 57
- 239000008280 blood Substances 0.000 title claims abstract description 57
- 230000035922 thirst Effects 0.000 title claims abstract description 35
- 238000002360 preparation method Methods 0.000 title claims abstract description 24
- 230000000694 effects Effects 0.000 claims abstract description 33
- 239000009636 Huang Qi Substances 0.000 claims abstract description 22
- 239000000463 material Substances 0.000 claims abstract description 21
- 229940079593 drug Drugs 0.000 claims abstract description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000000284 extract Substances 0.000 claims abstract description 18
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract description 17
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 15
- 238000000034 method Methods 0.000 claims abstract description 15
- 238000010521 absorption reaction Methods 0.000 claims abstract description 11
- 239000012141 concentrate Substances 0.000 claims abstract description 10
- 238000010828 elution Methods 0.000 claims abstract description 7
- 239000006187 pill Substances 0.000 claims abstract description 6
- 239000002994 raw material Substances 0.000 claims abstract description 6
- 238000000605 extraction Methods 0.000 claims abstract description 5
- 229940100688 oral solution Drugs 0.000 claims abstract description 5
- 239000002775 capsule Substances 0.000 claims abstract description 4
- 238000009472 formulation Methods 0.000 claims abstract description 4
- 239000007919 dispersible tablet Substances 0.000 claims abstract description 3
- 239000007938 effervescent tablet Substances 0.000 claims abstract description 3
- 239000008187 granular material Substances 0.000 claims abstract description 3
- -1 oral solution Substances 0.000 claims abstract description 3
- 238000012545 processing Methods 0.000 claims abstract description 3
- 239000003826 tablet Substances 0.000 claims abstract description 3
- 239000007901 soft capsule Substances 0.000 claims abstract 2
- 241000209020 Cornus Species 0.000 claims description 19
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 16
- 239000011347 resin Substances 0.000 claims description 14
- 229920005989 resin Polymers 0.000 claims description 14
- 235000019441 ethanol Nutrition 0.000 claims description 12
- 239000003480 eluent Substances 0.000 claims description 9
- 239000012530 fluid Substances 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 8
- 239000006228 supernatant Substances 0.000 claims description 8
- 238000001914 filtration Methods 0.000 claims description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 6
- 229920002472 Starch Polymers 0.000 claims description 6
- 235000019698 starch Nutrition 0.000 claims description 6
- 239000008107 starch Substances 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 5
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 4
- 235000012907 honey Nutrition 0.000 claims description 4
- 238000002386 leaching Methods 0.000 claims description 4
- 239000011148 porous material Substances 0.000 claims description 4
- 229920001353 Dextrin Polymers 0.000 claims description 3
- 239000004375 Dextrin Substances 0.000 claims description 3
- 235000019425 dextrin Nutrition 0.000 claims description 3
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 3
- 238000001291 vacuum drying Methods 0.000 claims description 3
- 239000002250 absorbent Substances 0.000 claims description 2
- 230000002745 absorbent Effects 0.000 claims description 2
- 230000006837 decompression Effects 0.000 claims 1
- 238000002592 echocardiography Methods 0.000 claims 1
- 238000004064 recycling Methods 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 abstract description 11
- 210000001124 body fluid Anatomy 0.000 abstract description 6
- 239000010839 body fluid Substances 0.000 abstract description 6
- 238000004519 manufacturing process Methods 0.000 abstract description 5
- 230000008569 process Effects 0.000 abstract description 5
- 239000007910 chewable tablet Substances 0.000 abstract description 2
- 240000006766 Cornus mas Species 0.000 abstract 1
- 229960001031 glucose Drugs 0.000 description 22
- 239000008103 glucose Substances 0.000 description 22
- 239000000243 solution Substances 0.000 description 19
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 15
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 13
- 210000002966 serum Anatomy 0.000 description 10
- 102000004506 Blood Proteins Human genes 0.000 description 7
- 108010017384 Blood Proteins Proteins 0.000 description 7
- 102000004877 Insulin Human genes 0.000 description 7
- 108090001061 Insulin Proteins 0.000 description 7
- 210000004072 lung Anatomy 0.000 description 7
- 230000001737 promoting effect Effects 0.000 description 7
- 235000009508 confectionery Nutrition 0.000 description 6
- 239000000706 filtrate Substances 0.000 description 6
- 229940125396 insulin Drugs 0.000 description 6
- 210000004185 liver Anatomy 0.000 description 6
- 241000699666 Mus <mouse, genus> Species 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 230000002218 hypoglycaemic effect Effects 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 230000007812 deficiency Effects 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 4
- 239000000796 flavoring agent Substances 0.000 description 4
- 235000019634 flavors Nutrition 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 210000002216 heart Anatomy 0.000 description 4
- 201000001421 hyperglycemia Diseases 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 230000000903 blocking effect Effects 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 235000014633 carbohydrates Nutrition 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 238000001802 infusion Methods 0.000 description 3
- 230000000144 pharmacologic effect Effects 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- 238000005728 strengthening Methods 0.000 description 3
- 230000001502 supplementing effect Effects 0.000 description 3
- 210000001835 viscera Anatomy 0.000 description 3
- SPFMQWBKVUQXJV-BTVCFUMJSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;hydrate Chemical compound O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O SPFMQWBKVUQXJV-BTVCFUMJSA-N 0.000 description 2
- 241000213006 Angelica dahurica Species 0.000 description 2
- QIIDATRCGITYRZ-UHFFFAOYSA-N Catalpol Natural products OCC1OC(OC2OC=CC3C(O)C(=C(CO)C23)O)C(O)C(O)C1O QIIDATRCGITYRZ-UHFFFAOYSA-N 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 206010022489 Insulin Resistance Diseases 0.000 description 2
- 241000699660 Mus musculus Species 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 241000590428 Panacea Species 0.000 description 2
- 208000001431 Psychomotor Agitation Diseases 0.000 description 2
- 206010038743 Restlessness Diseases 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- LHDWRKICQLTVDL-PZYDOOQISA-N catalpol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@H]1[C@@H]2[C@@]3(CO)O[C@H]3[C@@H](O)[C@@H]2C=CO1 LHDWRKICQLTVDL-PZYDOOQISA-N 0.000 description 2
- UXSACQOOWZMGSE-UHFFFAOYSA-N catalposide Natural products OC1C(O)C(O)C(CO)OC1OC1C2C3(CO)OC3C(OC(=O)C=3C=CC(O)=CC=3)C2C=CO1 UXSACQOOWZMGSE-UHFFFAOYSA-N 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 229960000673 dextrose monohydrate Drugs 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 239000007928 intraperitoneal injection Substances 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- LHDWRKICQLTVDL-UHFFFAOYSA-N methyl iridoid glycoside Natural products OC1C(O)C(O)C(CO)OC1OC1C2C3(CO)OC3C(O)C2C=CO1 LHDWRKICQLTVDL-UHFFFAOYSA-N 0.000 description 2
- 238000010172 mouse model Methods 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 230000003285 pharmacodynamic effect Effects 0.000 description 2
- 238000010791 quenching Methods 0.000 description 2
- 230000003014 reinforcing effect Effects 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 238000005292 vacuum distillation Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 description 1
- MCSXGCZMEPXKIW-UHFFFAOYSA-N 3-hydroxy-4-[(4-methyl-2-nitrophenyl)diazenyl]-N-(3-nitrophenyl)naphthalene-2-carboxamide Chemical compound Cc1ccc(N=Nc2c(O)c(cc3ccccc23)C(=O)Nc2cccc(c2)[N+]([O-])=O)c(c1)[N+]([O-])=O MCSXGCZMEPXKIW-UHFFFAOYSA-N 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010001580 Albuminuria Diseases 0.000 description 1
- 241001656831 Arctous alpina Species 0.000 description 1
- 201000004569 Blindness Diseases 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 206010010144 Completed suicide Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 206010011878 Deafness Diseases 0.000 description 1
- 206010013911 Dysgeusia Diseases 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 206010017711 Gangrene Diseases 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 229930186217 Glycolipid Natural products 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 206010061876 Obstruction Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 240000005373 Panax quinquefolius Species 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 208000031971 Yin Deficiency Diseases 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000006286 aqueous extract Substances 0.000 description 1
- 210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 description 1
- 230000002457 bidirectional effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 238000010241 blood sampling Methods 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 231100000895 deafness Toxicity 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 229940126534 drug product Drugs 0.000 description 1
- 208000017574 dry cough Diseases 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 210000001508 eye Anatomy 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 238000009313 farming Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 208000016354 hearing loss disease Diseases 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 239000004026 insulin derivative Substances 0.000 description 1
- 230000003914 insulin secretion Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- 230000037356 lipid metabolism Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 210000004279 orbit Anatomy 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000004224 protection Effects 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/40—Cornaceae (Dogwood family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of Chinese medicine compositions and its preparation method and application with lowering blood sugar and preventing thirst, belong to technical field of traditional Chinese medicine.The Chinese medicine composition includes raw material Radix Rehmanniae, Radix Ophiopogonis, pulp of dogwood fruit, Radix Astragali and Radix Angelicae Sinensis, and decoction, capsule, tablet, granule, pill, micropill preparation, soft capsule, dripping pill, oral solution, dispersible tablet, effervescent tablet or chewable tablets is made.Add water to obtain extracting solution raw material first, upper prop absorption is carried out to extracting solution and elution obtains concentrate, Chinese medicine composition extract is obtained to concentrate processing, then adding auxiliary material using conventional formulation method preparation has effects that the Chinese medicine composition of lowering blood sugar and preventing thirst.The formula of the invention is reasonable, has clearing heat and nourishing yin, the effect that nourshing kidney is promoted the production of body fluid.Preparation method simple process of the present invention, strong operability, extraction efficiency is high, and the dose of final products is small, quality controllable, has a good application prospect in terms of the drug of preparation treatment diabetes.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine, and in particular to a kind of to have effects that the Chinese medicine composition of lowering blood sugar and preventing thirst
And its preparation method and application.
Background technique
Diabetes are one group of metabolic diseases characterized by hyperglycemia, hyperglycemia be then due to defect of insulin secretion or
Its biological effect is impaired or both have concurrently caused by.Diabetes are long-standing hyperglycemia, will lead to various tissues, especially
Eye, kidney, heart, blood vessel, the chronic lesion of nerve, dysfunction.
Diabetes are the names of disease of traditional Chinese medicine, refer to drink, diuresis, more foods and thin, tired, urine sweet tea are main more
The symptom complex of feature.If doing laboratory examination, it is mainly characterized by hyperglycemia and glucose in urine, and mainly in lung, stomach, kidney, basic pathogenesis is
Yin jin loss, scorching inclined Sheng.It quenches one's thirst with the passing of time, the state of an illness is out of control, then yin deficiency affecting yang, the bright body fluid depletion causing blood stasis of heat, and causes impairment of both QI and YIN, yin-yang
All empty, channels stasis blocking, passages through which vital energy circulates dystrophy, qi and blood is inverse disorderly, internal organs organ it is impaired and occur furuncle, carbuncle, dizziness, thoracic obstruction, deafness, blindness,
Limbs fiber crops pain, lower limb gangrene, renal failure oedema, apoplectic coma etc. and disease.
In tradition application, the method that lowering blood sugar and preventing thirst recipe material mainly uses water to decoct, there are inconvenient for use, medicinal material utilizations
The disadvantages of rate is lower.
Summary of the invention
Goal of the invention: for the problem that lowering blood sugar and preventing thirst recipe material is inconvenient for use, utilization rate is low, this hair exists in the prior art
Bright be designed to provide a kind of has effects that the Chinese medicine composition of lowering blood sugar and preventing thirst.It is a further object of the present invention to provide in one kind
State the preparation method with the Chinese medicine composition of lowering blood sugar and preventing thirst.Further object of the present invention be to provide it is a kind of it is above-mentioned have disappear
The application of the Chinese medicine composition of thirsty function of reducing blood sugar.
Technical solution: to solve the above-mentioned problems, the technical solution adopted in the present invention is as follows:
It is a kind of to have effects that the Chinese medicine composition of lowering blood sugar and preventing thirst, it is grouped as by each group of following parts by weight: Radix Rehmanniae 5~20
Part, 5~20 parts of Radix Ophiopogonis, 5~20 parts of pulp of dogwood fruit, 5~20 parts of Radix Astragali, 5~20 parts of Radix Angelicae Sinensis.
Preferably, it is grouped as by each group of following parts by weight: 20 parts of Radix Rehmanniae, 20 parts of Radix Ophiopogonis, 15 parts of pulp of dogwood fruit, Radix Astragali 10
Part, 10 parts of Radix Angelicae Sinensis.
Preferably, it is grouped as by each group of following parts by weight: 20 parts of Radix Rehmanniae, 15 parts of Radix Ophiopogonis, 10 parts of pulp of dogwood fruit, Radix Astragali 8
Part, 6 parts of Radix Angelicae Sinensis.
Preferably, it is grouped as by each group of following parts by weight: 20 parts of Radix Rehmanniae, 15 parts of Radix Ophiopogonis, 12 parts of pulp of dogwood fruit, Radix Astragali 6
Part, 10 parts of Radix Angelicae Sinensis.
Preferably, it is grouped as by each group of following parts by weight: 15 parts of Radix Rehmanniae, 15 parts of Radix Ophiopogonis, 12 parts of pulp of dogwood fruit, Radix Astragali 8
Part, 8 parts of Radix Angelicae Sinensis.
Preferably, it is grouped as by each group of following parts by weight: 15 parts of Radix Rehmanniae, 15 parts of Radix Ophiopogonis, 10 parts of pulp of dogwood fruit, Radix Astragali 5
Part, 5 parts of Radix Angelicae Sinensis.
Preferably, the dosage form of above-mentioned Chinese medicine composition is decoction, capsule, tablet, granule, pill, micropill preparation, flexible glue
Capsule, dripping pill, oral solution, dispersible tablet, effervescent tablet or chewable tablets.
Main ingredient Radix Rehmanniae is referred to as one of Chinese medicine treatment diabete four big " panacea " in side, has clearing heat and promoting fluid, the work of cool blood
With.Radix Rehmanniae is sweet in flavor, cold in nature.Return heart, liver and kidney channel.Function clearing heat and cooling blood, yin-nourishing are promoted the production of body fluid.For the deep red polydipsia of pyreticosis tongue, in the deficiency of Yin
Heat, hectic fever due to yin labor heat, Heat Diabetes ... " Mingyi Bielu ": " Great Cold, taste sweet and neutral are nontoxic.Solve all heat, blood-breaking, the tonneau moon water close
Absolutely.Not dredging water passages smash thin trusted subordinate, and can disappear extravasated blood.How hot patient is empty and, adds and uses it." modern research shows that Radix Rehmanniae Aqueous extracts pair
Adjusting grape cell sugar Equilibrium has remarkable effect, can improve islet beta cell function, by inhibiting adipose tissue phylaxin base
The expression of cause reduces insulin resistance level, improves disorders of lipid metabolism, to reduce blood glucose.Catalpol be in Radix Rehmanniae index at
Point, Catalpol can adjust the glycolipid metabolism of diabetic mice comprehensively, have certain treatment and prevention to diabetes and its complication
Effect.
Radix Ophiopogonis is sweet in flavor, slight bitter, and cold nature returns stomach, lung, the heart channel of Hang-Shaoyin, there is the effect of Yin nourishing and lung moistening, reinforcing stomach reg fluid, relieving restlessness and restlessness,
For diseases such as dryness of the lung dry cough, cough for deficiency of Yin consumptive disease, larynx numbness pharyngalgia, injury thirst, Heat Diabetes, vexed insomnia, dry constipation of intestines." the legendary god of farming
Book on Chinese herbal medicine warp " Radix Ophiopogonis is classified as to the top grade of Yin nourishing and lung moistening, saying it, " long term usage is made light of one's life by commiting suicide, not old not hungry." ophiopogonpolysaccharide have hypoglycemic work
With.
Pulp of dogwood fruit is sour, tepor, mild-natured.Function nourishing liver and kidney, arresting seminal emission gas, Gu collapse." name doctor amended record ": " middle benefit gas, lower gas,
Perspiration, Qiang Yin, strengthening the essence, five viscera settling lead to nine orifices, only small convenience, improving eyesight, strength ".Pharmacological research shows that Radix Rehmanniae has with Fructus Corni
Have and adjusts the pharmacological actions such as immune, anti-inflammatory, sterilization, hypoglycemic, anti-aging.With nourishing liver and kidney, arresting seminal emission gas, admittedly the effect collapsed,
It contains black bearberry acrylic component and iridoid constituents all have apparent hypoglycemic effect.
Radix Astragali is sweet in flavor, slightly warm in nature；Return lung, spleen, liver kidney channel；Shennong's Herbal, which records Radix Astragali, " it is deficient to mend husband, the exhaustion or lesion of the five internal organs
It is thin thin, quench the thirst, abdominal pain lets out dysentery, QI invigorating, Li Yin gas." in conjunction with the with the passing of time interpretation of the cause, onset and process of an illness of deficiency of both qi and yin of quenching one's thirst.Modern pharmacological research result
Show that it is improved immunity function, anti-oxidant, protection cardiovascular and cerebrovascular, renal function, kidney etc., reducing blood lipid, hypoglycemic, elimination sugar
Urinate the effect of sick albuminuria.Have the effect of invigorating qi for strengthening superficies, there is increase insulin sensitivity, the effect of bidirectional modulation blood glucose.
Chinese angelica blood supplementing promoting blood circulation, menstruction regulating and pain relieving.It is sweet, pungent, warm, return liver, the heart, the spleen channel, enrich blood, invigorates blood circulation, analgesic." Jing Yuequan
Books grass is just ": " Radix Angelicae Sinensis, it is sweet in flavor and weigh, therefore can specially enrich blood；Its gas is light and pungent, therefore again can promoting circulation of blood.Bowl spares has, has in row
It mends, the gas medicine in sincere blood, also the panacea in blood."
Radix Rehmanniae clearing heat and promoting fluid is monarch drug in a prescription in we, and Radix Ophiopogonis Yin nourishing and lung moistening, reinforcing stomach reg fluid are ministerial drug, and Radix Rehmanniae is helped to play heat-clearing
The effect of promoting the production of body fluid.Fructus Corni nourishing liver and kidney, arresting seminal emission gas, Radix Astragali invigorating qi for strengthening superficies help the nourishing yin effect of Radix Rehmanniae altogether, and Chinese angelica blood supplementing promoting blood circulation is closed
Make for assistant, three medicines are shared to help Radix Rehmanniae nourishing Yin and promoting production of body fluid.We have supplementing qi and nourishing yin, the effect of tonifying spleen nourshing kidney, to deficiency of both qi and yin and
The diabetic better effect of eating and drinking without temperance, body obesity.
The above-mentioned preparation method with the Chinese medicine composition of lowering blood sugar and preventing thirst adds water to obtain extracting solution raw material first,
Upper prop absorption is carried out to extracting solution and elution obtains concentrate, Chinese medicine composition extract is obtained to concentrate processing, is then added
Auxiliary material is added to have effects that the Chinese medicine composition of lowering blood sugar and preventing thirst using conventional formulation method preparation.Concrete operations are as follows:
A) it prepares extracting solution: the raw material being uniformly mixed by its parts by weight, extracting in water 2 times, water when extracting for the first time
Dosage be 10 times, time 2h of quality of medicinal material, the dosage of water is 8 times of quality of medicinal material when extracting for second, the time is 1~
2h merges the extracting solution of 2 extraction process, and filtering, every kilogram of crude drug is concentrated into 2000~5000mL medical fluid, then leaching supernatant
Liquid obtains extracting solution；
B) upper prop absorption and elution extracting solution: by the supernatant to be equivalent to resin volume 0.1%~2% per minute
Large pore resin absorption column adsorbs on flow velocity, discards efflux, and it is faint yellow for being washed with deionized to efflux, discards outflow
Liquid, then with 5%~15% C1-3 alcohol solution make eluent to efflux be it is faint yellow, discard efflux, then use
40%~80% C1-3 alcohol solution is eluted to faint yellow, collection eluent, and eluent, which is recovered under reduced pressure, removes C1-3 alcohol, concentration
It is equivalent to 0.5~2g crude drug to 1mL recovered liquid, it is cooling；The C1-3 alcohol is methanol, ethyl alcohol, normal propyl alcohol or isopropanol；It is described big
Macroporous adsorbent resin is D101 type, HPD-100 type, HPD-300 type or AB-8 type macroporous absorbent resin；
C) prepare extract: the filtering of gained concentrate, concentration, 60 DEG C of crushed after being dried obtain Chinese medicine in a vacuum drying oven
Composition extract；
D) it prepares Chinese medicine composition: gained Chinese medicine composition extract being added into auxiliary material, is made of conventional formulation method
Chinese medicine composition, the auxiliary material are mixture one or more of in dextrin, starch or refined honey.
Application of the above-mentioned Chinese medicine composition with lowering blood sugar and preventing thirst in the drug of preparation treatment diabetes.
The utility model has the advantages that compared with prior art, the invention has the advantages that
(1) the formula of the invention is reasonable, has clearing heat and nourishing yin, and the effect that nourshing kidney is promoted the production of body fluid has diabetes (diabetes)
Good therapeutic effect.
(2) the traditional chinese medicine composition of the invention preparation process is advanced, and dose is reduced to originally compared with traditional original side decoction
1/100~1/200.
(3) Chinese medicine composition extract that the present invention is prepared is solid powder, and quality is stablized, easy to use, can be made
Standby a variety of oral drug preparations.
(4) preparation method process stabilizing of the present invention, favorable reproducibility.
(5) the traditional chinese medicine composition of the invention is through related pharmacodynamic experiment, it was demonstrated that has preferable hypoglycemic effect.
Specific embodiment
In order to make the foregoing objectives, features and advantages of the present invention clearer and more comprehensible, right combined with specific embodiments below
A specific embodiment of the invention is described in detail.
Embodiment 1
It is a kind of to have effects that the Chinese medicine composition of lowering blood sugar and preventing thirst, it is made of following each component: Radix Rehmanniae 20g, Radix Ophiopogonis 20g, mountain
Cornus 15g, Radix Astragali 10g, Radix Angelicae Sinensis 10g.
The above-mentioned preparation method with the Chinese medicine composition of lowering blood sugar and preventing thirst, comprising the following steps:
A) it prepares extracting solution: the above medicinal material being uniformly mixed, is placed in extractor, water boiling is added to extract 2 times, each water
Dosage is respectively 10 times of quality of medicinal material, 8 times, is extracted 2 hours for the first time, and second of extraction 2 hours merges No. 2 extracting solutions, with
The screen to filtrate, filtrate are placed in vacuum distillation pot and are concentrated under reduced pressure into appropriate (every kilogram of crude drug is concentrated into 2000ml medical fluid), leaching
Supernatant obtains extracting solution；
B) upper prop absorption and elution extracting solution: by above-mentioned supernatant be equivalent on 1% flow velocity of resin volume per minute
D101 type large pore resin absorption column (mass ratio of resin and medicinal material is 1: 1), discards efflux, upper prop terminates；Use deionized water
Washing to efflux is faint yellow in right amount, discards efflux；Then it is eluted with the ethanol water that mass percent is 5%
Agent discards efflux；It is faint yellow for being eluted again with 60% ethanol water to efflux, collects eluent, is recovered under reduced pressure and removes
Ethyl alcohol is removed, 1mL recovered liquid is concentrated into and is equivalent to 2g crude drug, it is cooling；
C) prepare extract: concentrate filtering, filtrate is concentrated to dryness, be placed in a vacuum drying oven 60 DEG C be dried under reduced pressure it is blocking
Dry block is crushed, obtains Chinese medicine composition extract by shape；
D) prepare Chinese medicine composition: by above-mentioned Chinese medicine composition extract routinely technique add conventional pharmaceutical adjuvants dextrin and
Starch mixes pelleting agent.
Embodiment 2
It is a kind of to have effects that the Chinese medicine composition of lowering blood sugar and preventing thirst, it is made of following each component: Radix Rehmanniae 20g, Radix Ophiopogonis 15g, mountain
Cornus 10g, Radix Astragali 8g, Radix Angelicae Sinensis 6g.
The above-mentioned preparation method with the Chinese medicine composition of lowering blood sugar and preventing thirst, comprising the following steps:
A) it prepares extracting solution: the above medicinal material being uniformly mixed, is placed in extractor, water boiling is added to extract 2 times, each water
Dosage is respectively 10 times of quality of medicinal material, 8 times, is extracted 2 hours for the first time, and second of extraction 1 hour merges No. 2 extracting solutions, with
The screen to filtrate, filtrate are placed in vacuum distillation pot and are concentrated under reduced pressure into appropriate (every kilogram of crude drug is concentrated into 3000mL medical fluid), leaching
Supernatant obtains extracting solution；
B) upper prop absorption and elution extracting solution: by above-mentioned supernatant be equivalent on 2% flow velocity of resin volume per minute
D101 type large pore resin absorption column (mass ratio of resin and medicinal material is 1: 1), discards efflux, upper prop terminates；Use deionized water
Washing to efflux is faint yellow in right amount, discards efflux；Then make eluant, eluent with 10% ethanol water, discard outflow
Liquid；It is faint yellow for being eluted again with 50% ethanol water to efflux, collects eluent, removing ethyl alcohol is recovered under reduced pressure, be concentrated
It is equivalent to 2g crude drug to 1mL recovered liquid, it is cooling；
C) prepare extract: concentrate filtering, filtrate is concentrated to dryness, set in vacuum oven 60 DEG C be dried under reduced pressure it is blocking
Dry block is crushed, obtains Chinese medicine composition extract by shape；
D) prepare Chinese medicine composition: by above-mentioned composition, routinely technique adds conventional pharmaceutical adjuvants starch to mix film-making agent.
Embodiment 3
It is a kind of to have effects that the Chinese medicine composition of lowering blood sugar and preventing thirst, it is made of following each component: Radix Rehmanniae 20g, Radix Ophiopogonis 15g, mountain
Cornus 12g, Radix Astragali 6g, Radix Angelicae Sinensis 10g.
The preparation method of extract is the same as embodiment 2.
Above-mentioned composition added starch mixing particle is made according to a conventional method, add appropriate magnesium stearate that glue is made by specification again
Wafer.
Embodiment 4
It is a kind of to have effects that the Chinese medicine composition of lowering blood sugar and preventing thirst, it is made of following each component: Radix Rehmanniae 15g, Radix Ophiopogonis 15g, mountain
Cornus 12g, Radix Astragali 8g, Radix Angelicae Sinensis 8g.
The preparation method of extract is the same as embodiment 2.
Above-mentioned composition is dissolved in water filtration according to common process, appropriate refined honey is added and oral solution is made.
Embodiment 5
It is a kind of to have effects that the Chinese medicine composition of lowering blood sugar and preventing thirst, it is made of following each component: Radix Rehmanniae 15g, Radix Ophiopogonis 15g, mountain
Cornus 10g, Radix Astragali 5g, Radix Angelicae Sinensis 5g.
The preparation method of extract is the same as embodiment 2.
Above-mentioned composition is dissolved in water filtration according to common process, appropriate refined honey is added and oral solution is made.
Embodiment 6
The curative effect generated to db/db (diabetic mice) is observed using drug products made from embodiment 1.
1.1 animal
Control group: common mouse, cleaning grade, male, 7~8 week old, 10；Experimental group: db/db (diabetic mice),
SPF grades, 7~8 week old, 50.
The setting of 1.2 dosage and grouping
Db/db mouse buys adaptation raising 1 week, and fasting 16h measures fasting blood-glucose, and fasting blood-glucose is selected to be higher than
The animal of 11.1mmol/L is randomly divided into 5 groups, every group 10.Separately set common mouse as a control group, 10/group.
(1) control group
(2) diabetic model group (0.5%CMC-Na solution)
(3) positive drug melbine, 50mg/kg
(4) Chinese medicine composition high dose group, 80mg/kg (8g crude drug/kg)
(5) Chinese medicine composition middle dose group, 40mg/kg (4g crude drug/kg)
(6) Chinese medicine composition low dose group, 20mg/kg (2g crude drug/kg)
1.3 Testing index and time
1.3.1 fasting blood-glucose
Before administration and 2 weeks during administration measure 1 time, overnight fasting, and eye socket blood sampling measures fasting blood-glucose.
1.3.2 carbohydrate tolerance test
(0h, 0.5h, 1h after being administered are measured, when 2h in progresss stomach-filling starch (2.5g/kg) carbohydrate tolerance test in the 8th week is administered
Blood glucose value)；In administration carry out within the 10th week intraperitoneal injection glucose (2.5g/kg) carbohydrate tolerance test (0h after measurement administration,
Blood glucose value when 0.5h, 1h, 2h).
1.3.3 Biochemical Indices In Serum
Be administered the 10th week, overnight fasting, last dose for 24 hours after, adopt whole blood, separate serum, carry out insulin
(Ins), glycated serum protein (GSP) measures.
2. result
The influence of 2.1 pairs of fasting blood-glucoses
After being administered 4 weeks, each dosage group of Chinese medicine composition has obvious reduction to act on the fasting blood-glucose of db/db mouse,
Decreasing ratio is 10%~30%.Compared with model group, Fractional and time point have significant decrease (P < 0.05, P <
0.01)。
Influence (mean ± SD) of the table .1 Chinese medicine composition gastric infusion to db/db mouse fasting blood-glucose (mmol/L)
Normal group of 0.01vs of * P <；#P < 0.05, ##P < 0.01vs model group.
The influence of 2.2 pairs of intraperitoneal injection glucose tolerances
Compared with model group, the blood glucose value in Chinese medicine composition height, middle dose group injectable dextrose monohydrate 2h is substantially reduced (P
< 0.05, P < 0.01), low dose group can also reduce by 2 hours after blood glucose level (P < 0.05), Chinese medicine composition is to 1h, 2h
Blood glucose level have apparent reduction effect (P < 0.05).
Table .2 Chinese medicine composition gastric infusion is to blood glucose (mmol/L) after db/db mouse peritoneal injection 2.5g/kg glucose
Influence (mean ± SD)
Normal group of 0.01vs of * P <；#P < 0.05, ##P < 0.01vs model group.
The influence of 2.3 pairs of serum insulins and glycated serum protein
Compared with intact animal, db/db model mice serum insulin and the horizontal apparent increase (P of glycated serum protein
< 0.01).Compared with model group, each tested group including positive drug influences serum insulin without apparent.Chinese medicine
Composition is high, middle dose group can obviously reduce serum glycated serum protein levels.
Table .3 Chinese medicine composition gastric infusion is to db/db mice serum insulin (Ins) and glycated serum protein (GSP)
It influences (mean ± SD)
Normal group of 0.01vs of * P <；#P < 0.05vs model group.
Pharmacodynamic test shows that each dosage group of Chinese medicine composition has the fasting blood-glucose of db/db mouse significantly to reduce and makees
With decreasing ratio is 10%~30%.Compared with model group, Chinese medicine composition is high, in middle dose group injectable dextrose monohydrate 2 hours
Blood glucose value is substantially reduced (P < 0.05, P < 0.01), low dose group can also reduce by 2 hours after blood glucose level (P < 0.05),
Chinese medicine composition has apparent reduction effect (P < 0.05) to the blood glucose level of 1h, 2h.
Compared with intact animal, db/db model mice serum insulin and the horizontal apparent increase (P of glycated serum protein
< 0.01).Compared with model group, each tested group including positive drug influences serum insulin without apparent.Chinese medicine
Composition is high, middle dose group can obviously reduce serum glycated serum protein levels.
Claims (10)
1. a kind of have effects that the Chinese medicine composition of lowering blood sugar and preventing thirst, which is characterized in that be grouped as by each group of following parts by weight:
5~20 parts of Radix Rehmanniae, 5~20 parts of Radix Ophiopogonis, 5~20 parts of pulp of dogwood fruit, 5~20 parts of Radix Astragali, 5~20 parts of Radix Angelicae Sinensis.
2. according to claim 1 have effects that the Chinese medicine composition of lowering blood sugar and preventing thirst, which is characterized in that by following parts by weight
Several each groups are grouped as: 20 parts of Radix Rehmanniae, 20 parts of Radix Ophiopogonis, 15 parts of pulp of dogwood fruit, 10 parts of Radix Astragali, 10 parts of Radix Angelicae Sinensis.
3. according to claim 1 have effects that the Chinese medicine composition of lowering blood sugar and preventing thirst, which is characterized in that by following parts by weight
Several each groups are grouped as: 20 parts of Radix Rehmanniae, 15 parts of Radix Ophiopogonis, 10 parts of pulp of dogwood fruit, 8 parts of Radix Astragali, 6 parts of Radix Angelicae Sinensis.
4. according to claim 1 have effects that the Chinese medicine composition of lowering blood sugar and preventing thirst, which is characterized in that by following parts by weight
Several each groups are grouped as: 20 parts of Radix Rehmanniae, 15 parts of Radix Ophiopogonis, 12 parts of pulp of dogwood fruit, 6 parts of Radix Astragali, 10 parts of Radix Angelicae Sinensis.
5. according to claim 1 have effects that the Chinese medicine composition of lowering blood sugar and preventing thirst, which is characterized in that by following parts by weight
Several each groups are grouped as: 15 parts of Radix Rehmanniae, 15 parts of Radix Ophiopogonis, 12 parts of pulp of dogwood fruit, 8 parts of Radix Astragali, 8 parts of Radix Angelicae Sinensis.
6. according to claim 1 have effects that the Chinese medicine composition of lowering blood sugar and preventing thirst, which is characterized in that by following parts by weight
Several each groups are grouped as: 15 parts of Radix Rehmanniae, 15 parts of Radix Ophiopogonis, 10 parts of pulp of dogwood fruit, 5 parts of Radix Astragali, 5 parts of Radix Angelicae Sinensis.
7. described in any item according to claim 1~6 have effects that the Chinese medicine composition of lowering blood sugar and preventing thirst, which is characterized in that agent
Type is decoction, capsule, tablet, granule, pill, micropill preparation, soft capsule, dripping pill, oral solution, dispersible tablet, effervescent tablet or nozzle
Chew piece.
8. a kind of prepare the described in any item methods with the Chinese medicine composition of lowering blood sugar and preventing thirst of claim 1~6, spy
Sign is, adds water to obtain extracting solution raw material Radix Rehmanniae, Radix Ophiopogonis, pulp of dogwood fruit, Radix Astragali, Radix Angelicae Sinensis first, carries out upper prop suction to extracting solution
It echos elution and obtains concentrate, Chinese medicine composition extract is obtained to concentrate processing, then adds auxiliary material using conventional system
Agent method prepares the Chinese medicine composition with lowering blood sugar and preventing thirst.
9. the preparation method with the Chinese medicine composition of lowering blood sugar and preventing thirst according to claim 8, which is characterized in that packet
Include following steps:
A) it prepares extracting solution: the raw material being uniformly mixed by its parts by weight, extracting in water 2 times, the use of water when extracting for the first time
Amount is 10 times, time 2h of quality of medicinal material, and the dosage of water is 8 times of quality of medicinal material when extracting for the second time, and the time is 1~2h,
Merge the extracting solution of 2 extraction process, filter, every kilogram of crude drug is concentrated into 2000~5000mL medical fluid, then leaching supernatant, obtains
Obtain extracting solution；
B) supernatant upper prop absorption and elution extracting solution: is equivalent to the flow velocity of resin volume 0.1%~2% per minute
The mass ratio of upper large pore resin absorption column absorption, resin and medicinal material is 1: 1, discards efflux, is washed with deionized to outflow
Liquid be it is faint yellow, discard efflux, then with 5%~15% C1-3 alcohol solution make eluent to efflux be it is yellowish
Color discards efflux, then faint yellow, collection eluent, eluent decompression are eluted to 40%~80% C1-3 alcohol solution
Recycling removes C1-3 alcohol, is concentrated into 1mL recovered liquid and is equivalent to 0.5~2g crude drug, cooling；The C1-3 alcohol is methanol, ethyl alcohol, just
Propyl alcohol or isopropanol；The macroporous absorbent resin is D101 type, HPD-100 type, HPD-300 type or AB-8 type；
C) prepare extract: the filtering of gained concentrate, concentration, 60 DEG C of crushed after being dried obtain Chinese traditional medicine composition in a vacuum drying oven
Object extract；
D) it prepares Chinese medicine composition: gained Chinese medicine composition extract is added into auxiliary material, Chinese medicine is made with conventional formulation method
Composition, the auxiliary material are mixture one or more of in dextrin, starch or refined honey.
10. the described in any item Chinese medicine compositions with lowering blood sugar and preventing thirst of claim 1~6 are in preparation treatment diabetes
Application in drug.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811337167.1A CN109106848A (en) | 2018-11-09 | 2018-11-09 | A kind of Chinese medicine composition and its preparation method and application with lowering blood sugar and preventing thirst |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811337167.1A CN109106848A (en) | 2018-11-09 | 2018-11-09 | A kind of Chinese medicine composition and its preparation method and application with lowering blood sugar and preventing thirst |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109106848A true CN109106848A (en) | 2019-01-01 |
Family
ID=64853898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811337167.1A Pending CN109106848A (en) | 2018-11-09 | 2018-11-09 | A kind of Chinese medicine composition and its preparation method and application with lowering blood sugar and preventing thirst |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109106848A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101120993A (en) * | 2006-08-08 | 2008-02-13 | 芮育健 | New use of traditional Chinese medicines rehmanniae radix, asparagus cochinchinensis, and ophiopogon Japonicus for qi-replenishing yin-nourishing and treating diabetes |
| CN104758736A (en) * | 2015-04-13 | 2015-07-08 | 蒋来明 | Blood-glucose-reducing traditional Chinese medicine composition and preparation method thereof |
| CN105853928A (en) * | 2016-05-24 | 2016-08-17 | 南京市妇幼保健院 | Medicine composition for treating intrahepatic cholestasis of pregnancy and preparation method thereof |
| CN106806618A (en) * | 2015-11-27 | 2017-06-09 | 吴昊 | A kind of formula for treating diabetes |
| CN107536946A (en) * | 2016-06-27 | 2018-01-05 | 戚友亦 | A kind of Chinese medicine preparation for treating diabetes |
-
2018
- 2018-11-09 CN CN201811337167.1A patent/CN109106848A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101120993A (en) * | 2006-08-08 | 2008-02-13 | 芮育健 | New use of traditional Chinese medicines rehmanniae radix, asparagus cochinchinensis, and ophiopogon Japonicus for qi-replenishing yin-nourishing and treating diabetes |
| CN104758736A (en) * | 2015-04-13 | 2015-07-08 | 蒋来明 | Blood-glucose-reducing traditional Chinese medicine composition and preparation method thereof |
| CN106806618A (en) * | 2015-11-27 | 2017-06-09 | 吴昊 | A kind of formula for treating diabetes |
| CN105853928A (en) * | 2016-05-24 | 2016-08-17 | 南京市妇幼保健院 | Medicine composition for treating intrahepatic cholestasis of pregnancy and preparation method thereof |
| CN107536946A (en) * | 2016-06-27 | 2018-01-05 | 戚友亦 | A kind of Chinese medicine preparation for treating diabetes |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101002906A (en) | Compounding traditional Chinese medicine, and its use | |
| CN102114102B (en) | Traditional Chinese medicine extract mixed preparation and application thereof | |
| CN1299742C (en) | Medicine for treating diabetes, and its prepn. method | |
| CN106177053A (en) | A kind of Hyperglycemic health care compositions comprising leaf of Cyclocarya paliurus Iljinskaja and Pericarpium Citri Reticulatae | |
| CN105194421A (en) | Self-heal health-care oral solution capable of reducing blood fat and preparation method thereof | |
| CN106173605A (en) | A kind of Hyperglycemic health care compositions comprising Radix Puerariae and Herba Dendrobii | |
| CN105267559B (en) | A kind of drug and preparation method thereof for treating diabete peripheral herve pathology | |
| CN102048841B (en) | Lactogenic traditional Chinese medicine composition and preparation method thereof | |
| CN103432420B (en) | A kind of Chinese medicine composition for the treatment of diabetes and preparation method thereof and detection method | |
| CN104888158A (en) | Folium apocyni veneti oral liquid for enhancing immunity and preparation method thereof | |
| CN108524811A (en) | Reduce uric acid, cholesterol, three high Chinese medicine compositions and its preparation method for the treatment of | |
| CN106177054A (en) | A kind of Hyperglycemic health care compositions comprising Cortex Mori and Pericarpium Citri Reticulatae | |
| CN103463244A (en) | Method for extracting blood sugar lowering substance from China roses and application of blood sugar lowering substance | |
| CN114145374A (en) | Astragalus membranaceus and corn stigma composite tea and preparation method and application thereof | |
| CN113827660A (en) | Traditional Chinese medicine composition for reducing blood sugar and blood fat and preparation method thereof | |
| CN109106848A (en) | A kind of Chinese medicine composition and its preparation method and application with lowering blood sugar and preventing thirst | |
| CN103372138B (en) | A kind of pharmaceutical composition containing Shengmai Yin active ingredient and preparation method thereof | |
| CN106038869B (en) | A kind of compound guava preparation and preparation method thereof | |
| CN106177476A (en) | A kind of Hyperglycemic health care compositions comprising Herba Dendrobii and Pericarpium Citri Reticulatae | |
| CN105535070B (en) | The pharmaceutical composition and its preparation method and application for treating diabetes | |
| CN104257755A (en) | Composition with effect of treating diabetes as well as preparation method and application of composition | |
| CN103989940A (en) | Traditional Chinese medicine composition for treating diabetes mellitus | |
| CN100484543C (en) | Medicament composition for treating hepatitis, prepartion method and use | |
| CN114712458B (en) | Pharmaceutical composition for treating vascular aging of hypertension and preparation method and application thereof | |
| CN103860877A (en) | Pharmaceutical composition for treating diabetes, and preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190101 |
|
| RJ01 | Rejection of invention patent application after publication |