CN102755516A - Traditional Chinese medicine preparation for inhibiting human immunodeficiency virus and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine preparation for inhibiting human immunodeficiency virus. The traditional Chinese medicine preparation is characterized by being prepared from the following traditional Chinese medicines in parts by weight: 10-30 parts of radix astragali, 5-15 parts of rhizoma atractylodis macrocephalae, 5-15 parts of radix paeoniae alba, 5-15 parts of codonopsis pilosula, 5-15 parts of radix rehmanniae preparata, 5-15 parts of lycium barbarum, 5-15 parts of fructus corni, 5-15 parts of fructus psoraleae, 5-15 parts of radix ophiopogonis, 10-20 parts of lucid ganoderma, 5-15 parts of human placenta, 15-30 parts of gecko, 5-15 parts of cassia twig and 5-15 parts of Chinese date. In accordance with the traditional Chinese medicine clinical characteristics of AIDs and the Clinical Technical Solution for Treating AIDs with Traditional Chinese Medicine (on Trial) formulated by the state administration of traditional Chinese medicine and in combination with the factors of climatic characteristics of Guangxi, constitutive characters, environmental factors, people conditions and the like, a therapeutic medicine suitable for most of the infected people in Guangxi is created, and the medicine has an effect of improving the related symptoms and signs of AIDs. The traditional Chinese medicine preparation for treating AIDs disclosed by the invention has a better effect of improving weakness, anorexia, breath shortness and lumbago when combined with antiviral drug than the treatment with antiviral drug only.

Description

Suppress Chinese medicine preparation of HIV and preparation method thereof

Technical field

The invention discloses a kind of medicine that suppresses HIV and preparation method thereof, specifically is pharmaceutical formulation and the method for preparing of related preparations thereof of the auxiliary treatment AIDS of raw material with Chinese medicine, belongs to the field of Chinese medicines.

Background technology

AIDS, promptly AIDS (translate again: acquired immunity defective syndrome), the transliteration of english abbreviation AIDS (Acquired Immune Deficiency Syndrome).AIDS originates from Africa, and the back is brought the U.S. into by the immigrant.On June 5th, 1981, U.S. Atlanta Center for Disease Control (CDC) has briefly introduced 5 routine AIDS patients' medical history on " incidence and mortality weekly ", and this is the formal record of for the first time relevant AIDS in the world.Nineteen eighty-two, this disease is named as " AIDS ".In the near future, the AIDS rapid spread is to each continent.1985, one to the foreign nationality of travel in China young ill move in after the BJ Union Hospital very fast dead, after be proved and die from AIDS.This is that China finds AIDS for the first time.AIDS is seriously threatening human existence, has caused the great attention of World Health Organization (WHO) and national governments.AIDS propagation worldwide is more and swifter and more violent, and the development of human beings'health and society in serious threat, has become the fourth-largest killer who threatens health of people.Announced that since confirming AIDS first in June, 1981 whole world accumulative total has 6,500 ten thousand people's aids infections poison in the period of 25 in UNAIDS on May 30th, 2006, wherein 2,500,000 people are dead.To the end of the year 2005, the whole world has 3,860 ten thousand patients infected hivs, newly-increased then patients infected hiv 4,100,000 people, and other has 2,800,000 people to die from AIDS.Point out according to UNAIDS's " popular status report of 2008 AIDS "; 2007; The effort that the whole world prevents and treats AIDS makes remarkable progress, and AIDS popular appearing first defuses a situation, newly-increased HIV patient's quantity and all occur descending because of the dead number of AIDS.The newly-increased HIV patient 2,700,000 in the whole world in 2007 has descended 300,000 than the calendar year 2001; The number dead because of AIDS is 2,000,000, descends 200,000 than the calendar year 2001.

To the present definite Therapeutic Method of inefficacy still of AIDS, the traditional Chinese medical science integrally-regulated through to body dialectically combines with differential diagnosis of diseases; Can improve patient's symptom, improve life quality, alleviate the toxic and side effects of antiviral drugs; The human body immunity improving function, the incidence rate of minimizing opportunistic infection.These advantages of Chinese traditional treatment have demonstrated great vitality, also for the patient that can not accept antiviral therapy new treatment approach are provided simultaneously.It is introduced that patients infected hiv is counted from initial infection, pass through the several years even reached 10 years or just can develop into the AIDS patient after longer incubation period.AIDS patient multiple infection can occur because of resistivity extremely descends; Like herpes zoster, Fungi Infection of Oral, pulmonary tuberculosis, the enteritis that the specific disease pathogenic microorganism causes, pneumonia, encephalitis, candidiasis; The severe infections that several diseases substances such as lung sac worm cause etc.; Malignant tumor usually takes place in the later stage, and until consuming because of long-term, whole body dies of exhaustion and dies.

Though the numerous medical research personnel in the whole world have paid huge effort, do not develop the specific medicament of radical cure AIDS so far as yet, not can be used for the effective vaccine that prevents yet.

AIDS is very fast at more western geographic spread speeds ratios.Department of Public Health learns from Guangxi Zhuang Autonomous Region a few days ago, and by October 31 this year, Guangxi accumulative total is reported the AIDSinfected patient 51877 examples, and number of the infected rises to second in the whole nation.At present, on average there is 30 people's aids infections virus in Guangxi every day approximately, and the situation is tense for anti-Chinese mugwort.Because regional culture background and life style and customs is different; Schooling is low; Some patients are difficult to accept conventional therapeutic modality; This just requires the treatment of AIDS must take into account all kinds of crowds in the different society culture background, after expert group's research, and modal two kinds of pattern of syndrome qi-deficiency types of Guangxi HIV sufferers and damp-heat type; Therefore; " the Chinese medicine AIDS clinical technology scheme (trying) " that necessary tcm clinical practice characteristics and State Administration of Traditional Chinese Medicine according to Guangxi AIDS works out is in conjunction with factors such as the climate characteristic in Guangxi, constitutive character, environmental factors, staff condition, a kind of medicine that adapts to the most of infection populations in Guangxi of innovation and creation.

Summary of the invention

The object of the invention is exactly to modal two kinds of pattern of syndrome qi-deficiency types of Guangxi HIV sufferers and damp-heat type; In conjunction with factors such as the climate characteristic in Guangxi, constitutive character, environmental factors, staff conditions, Chinese medicine preparation of a kind of inhibition HIV that adapts to the most of HIV infection crowds in Guangxi and preparation method thereof is provided.

The present invention is achieved in that

The present invention suppresses the Chinese medicine preparation of HIV, it is characterized in that: this Chinese medicine preparation is processed by following parts by weight of traditional Chinese medicines raw material:

Radix Astragali 10-30;

Rhizoma Atractylodis Macrocephalae 5-15;

Radix Paeoniae Alba 5-15;

Radix Codonopsis 5-15;

Radix Rehmanniae Preparata 5-15;

Fructus Lycii 5-15;

Fructus Corni 5-15;

Fructus Psoraleae 5-15;

Radix Ophiopogonis 5-15;

Ganoderma 10-20;

Placenta Hominis 5-15;

Gecko 15-30;

Ramulus Cinnamomi 5-15;

Fructus Jujubae 5-15.

The Chinese medicine preparation of above-mentioned inhibition HIV can the intravital HIV-1 carrying capacity of patient become stable, can suppress HIV-1 virus, and safe and reliable, the toxic and side effects of not taking similar Western medicine and being caused.Its price only reaches 1/10 of similar Western medicine.The achievement that this institute is obtained will be as the adjuvant drug of AIDS virus resisting.

Each medicine active ingredient of the Chinese medicine preparation of the Chinese medicine preparation of above-described inhibition HIV is analyzed:

The Radix Astragali: have another name called: Radix Astragali, wear crushed grain, wear mulberry, solely mulberry, water caltrop grass, another name for Sichuan Province fat, hundred, Rhizoma Paridis tetraphyllae, continuous stilbene, the continuous Radix Astragali, be the general designation of plant and Chinese crude drug.Latin Astragalusmembranaceus (Fisch.) Bunge; English name: Astragalus Membranaceus is the root of leguminous plant Radix Astagali Astragalus membranaceus Bge. var.mongholicus (Bge.) Hsiao; Invigorating QI to consolidate the body surface resistance; The diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.It is weak to be used for the deficiency of vital energy, anorexia and loose stool, and sinking of QI of middle-JIAO, the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, deficiency of vital energy edema Radix Astragali disk, carbuncle is difficult bursts, and burst for a long time and do not hold back, the blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.Be used for deficiency of spleen-QI and stomach-QI; Deficiency of spleen-QI, sinking of QI of middle-JIAO, visceroptosis (proctoptosis, uterine prolapse, gastroptosis etc.); Insufficiency of lung-QI, cough with asthma is losed heart; Spontaneous sweating due to deficiency of QI is easy to flu; Deficiency of vital energy edema, dysuria; Insufficiency of vital energy and blood, anemia is sallow, or numb limbs and tense tendons, or skin infection, creation are difficult for healing; Quench one's thirst (diabetes).

The Rhizoma Atractylodis Macrocephalae: another name: Rhizoma Atractylodis Macrocephalae; The winter art; The winter Rhizoma Atractylodis Macrocephalae; Effects such as Latin Rhizoma Atractylodis Macrocephalae, English by name Largehead Atractylodes Rh, the Rhizoma Atractylodis Macrocephalae have adjustment gastrointestinal motility function, antiulcer, protect the liver, enhancing human body immunity function, anti-stress, enhancing hemopoietic function, antioxidation, slow down aging, blood sugar lowering, anticoagulation, antitumor." medicine origin " record: " the dry and middle QI invigorating of dehumidifying benefit, warming middle-JIAO removes the taste being attacked by dampness, removes gastric heat, and strong taste advance diet, quench the thirst, and are antiabortive." the modern pharmacological research confirmation, Rhizoma Atractylodis Macrocephalae decocting liquid has the effect of the HIV of inhibition.

The Radix Paeoniae Alba: latin name: Radix Paeoniae Alba, different name gold Radix Paeoniae, English name White Paeony Root is a Ranunculaceae Paeonia plant.Has antibacterial action.Be used for nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.1. " herbal classic ": " main pathogen stomachache is removed arthralgia due to stagnation of blood, and is broken hard long-pending, controls cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating." 2. " not Lu ": " clear and coherent blood vessels, slow in, dispelling malignant blood, expelling extravasated blood, the gas that anhydrates, sharp bladder, intestine and small intestine, subduing inflammation, row cold and heat when (controlling), attacked by pestiferous factors stomachache, lumbago."? ③" resistance ":" Treating Lung evil, belly Xu pain, blood gas accumulation, through the declaration of organs owned gas, cure evil pain septicemia, bone disease when the primary heat, strong internal organs, kidney qi, cure confidant Kennedy swelling, blood woman closed barrier, eliminate blood stasis, to eclipse pus. "

Radix Codonopsis: another name: Shangdang Radix Ginseng, windproof Radix Codonopsis, HUANGSHEN, preventing lanceolata, last Radix Codonopsis, SHITOUSEN, middle Ganoderma, yellow party; The Codonopsis plant, campanulaceae, English name: Root of Pilose Asiabell; Pilose Asiabell Root Moderate Asiabell Root Szechwon Tangshen Root; The Latin formal name used at school: Root of Pilose Asiabell, meridian distribution of property and flavor: property is flat, sweet in the mouth, little acid.Return spleen, lung meridian.Has invigorating the spleen and replenishing QI, the effect of spleen invigorating lung benefiting.Cure mainly weakness of the spleen and stomach, anorexia and loose stool, fatigue and weakness, the deficiency of the lung is breathed with cough, the lazy speech of breathing hard, spontaneous perspiration, blood deficiency and yellow complexion, thirsty.Be used for deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat is quenched one's thirst etc." Bencao Congxin " record: " invigorating the spleen and replenishing QI and taste, relieving thirst and restlessness.A little less than the middle feeble QI, mend in order to transfer, very smooth and proper.”

Radix Rehmanniae Preparata: have another name called Radix Rehmanniae Preparata or throw oneself on the ground; Belong to goatweed; Scrophulariaceae; English name: Prepared rhizome of Adhesive Rehmannia Latin literary fame: Radix Rehmanniae Preparata. Latin plant animal mineral name: Rehmannia glutinosa (Gaertn.) Libosch EX Fisch.et Mey. [property of medicine] is sweet, tepor.Return liver, kidney channel.[effect] yin nourishing of enriching blood, life essence-filling, marrow-benefitting.Cure mainly: the blood tiger is sallow; Dizzy cardiopalmus; Menoxenia; Collapse more than; Hepatic and renal YIN deficiency; Hectic fever night sweat; The seminal emission sexual impotence; Infertility; Soreness of the waist and knees; Hiccough and deaf; The head is dim-sighted; Early whitening of beard and hair; Quench one's thirst; Constipation; The dyspnea with rapid and short breath of suffering from a deficiency of the kidney.

Fructus Lycii: another name: der Bockdorn, the young thorn of red pearl, the right power of cattle, Canis familiaris L. serratd edge are the multi-branched shrub plants of Solanaceae Lycium, English name Barbary Wolfberry Fruit; The Latin formal name used at school is Lycium chinense; Has the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, blood-enriching tranquillizing; Promoting the production of body fluid to quench thirst, nourishing the lung to arrest cough.The treating the liver kidney yin is lost, soreness of the waist and knees, and dizziness, dizzy, the many tears of blurred vision, cough due to consumptive disease is quenched one's thirst, seminal emission.

Fructus Corni: another name: Fructus Corni, medicine Fructus Jujubae, Fructus Corni, another name for Sichuan Province Ziziphi Spinosae, meat Fructus Jujubae, potato Fructus Jujubae, chicken foot, real Fructus Jujubae, Fructus Corni, medicine Fructus Jujubae, day wooden seed, Fructus Corni, real Fructus Jujubae; English name: Medical Dogwood; Latin formal name used at school: Cornus officinalis, Cornaceae machaka or dungarunga, meridian distribution of property and flavor: sour, puckery; Tepor is returned liver, kidney channel; Function cures mainly: function: liver and kidney tonifying, restrain astringent or styptic treatment for spontaneous sweating, controlling nocturnal emission with astringent drugs reducing urination leukorrhagia stopping only collapses, hidroschesis, promoting the production of body fluid to quench thirst; Be used for soreness of waist and knee joint, dizziness and tinnitus, forgetful, emission and spermatorrhea, enuresis frequent micturition, bleeding not during menses menoxenia, profuse sweating collapse, interior-heat is quenched one's thirst.

Fructus Psoraleae: another name: GUZHI, bone fat, Fructus Psoraleae, thus fat, so son, so it, Semen Oroxyli is cherished Fructus Psoraleae; Broken event fat, Fructus Psoraleae, Fructus Psoraleae, broken frame, the solid fat of mother-in-law is mended the bone sparrow hawk; FRUCTUS PSORALEAE, black Semen Oroxyli, Hu Fructus Psoraleae, Hu Semen Allii Tuberosi, Ji Guzi and blue Herba Amaranthi tricoloris; Gu son, Gu fat, river Fructus Psoraleae, lucky Fructus Psoraleae, broken solid fat, Semen Allii Tuberosi recklessly; Leguminous plant; English name: Malaytea Scurfpea Fruit, Fruit of Malaytea Scurfpea Latin plant animal mineral name: Psoralea corylifolia L. nature and flavor: acrid in the mouth, hardship, warm in nature; Effect: reinforcing the kidney and supporting YANG, helping inspiration to relieve asthma, warming spleen and stopping diarrha; Function cures mainly: reinforcing the kidney and supporting YANG; Helping inspiration to relieve asthma; Warming spleen and stopping diarrha.Main insufficiency of kidney-YANG; Below element deficiency and cold; Chills and pain of the waist and kness; Impotence and seminal emission; Frequent micturition; The enuresis; Failure of the kidney in receiving QI; Dyspnea due to deficiency is more than; Asthenia of both the spleen and kidney; The stool chronic diarrhea; Vitiligo; Speckle is bald; Psoriasis.

Radix Ophiopogonis: have another name called Radix Ophiopogonis, dwarf lilyturf, book band grass; Liliaceae Ophiopogon perennial evergreen herbaceous plant; Latin formal name used at school: O.japonicus (L. f.) Ker-Gawl., meridian distribution of property and flavor: sweet, little hardship is slightly cold.GUIXIN, lung, stomach warp.The sick impairment of body fluid of effect 1. replenishing YIN and removing heat treatment interior-heat caused by deficiency of YIN or calentura, restlessness and thirst.2. thick, the QI rising in reverse order of cough, expectorant due to the nourishing the lung to arrest cough treatment dryness-heat impairing the lung.Function cures mainly: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.Be used for dryness of the lung dry cough.The chronic consumptive disease cough, Tianjin wound is thirsty, vexed insomnia, interior-heat is quenched one's thirst, the dryness of the intestine constipation; Pharyngeal diphtheria.Control dryness of the lung dry cough, spit blood, spitting of blood, consumptive lung disease, lung abscess, the asthenia dysphoria with smothery sensation is quenched one's thirst, and hinder in calentura Tianjin, dry mouth and throat, constipation.

Ganoderma: these article are Polyporaceae fungus Ganoderma lucidum (Leyss. Ex Fr.) Karst., Latin Ganoderma lucidum (Legss.ex Fr.) Karst. or Ganoderma Ganoderma sinense Zhao, the dry sporophore of Xust Zhang.Ganoderma just has the title of " Herba mesonae chinensis ", " Ganoderma " from ancient times, is the precious Chinese medicine of traditional Chinese medical science strengthening the body resistance, strengthening by means of tonics, in China long medicinal history is arranged, and medical value is high, is regarded as precious Chinese crude drug, is the treasure in the pools of traditional Chinese medicine.Eastern Han Dynasty's Shennong's Herbal is classified Ganoderma as top grade, thinks " eat for a long time, it is not old to make light of one's life by commiting suicide, and the angle prolongs life ".Modern medicine proves: Ganoderma contains several physiological active substances, can regulate and enhancing human immune.Current research shows that Ganoderma also has resisting fatigue, looks improving and the skin nourishing, slow down aging and prevents and treats effects such as AIDS.Ganoderan is one of effective ingredient in the Ganoderma, is the main component that improves body immunity function of a specified duration, strengthening the body resistance in the Ganoderma.The multiple pharmacologically active of Ganoderma is relevant with ganoderan mostly, has isolated kind more than 200 at present.Present known ganoderan has pharmacologically active widely, can improve body immunity and human body hypoxia-bearing capability, eliminates free radical; Suppress tumor, anti-radiation improves liver, bone marrow, blood synthetic DNA, RNA and protein ability; Life lengthening etc., ganoderan are water-soluble components.

Placenta Hominis: Latin Placenta Hominis, English name Human Placenta, another name: Placenta Hominis, afterbirth, afterbirth, afterbirth, plancenta hominis, Jing Heche, Du Heche.Have tonification, QI invigorating, nourish blood, benefit is smart.Be used to control deficient, weakness and emaciation, the consumptive fever hectic fever due to YIN-deficiency, cough with asthma, spitting of blood, night sweat, seminal emission, sexual impotence, women's vim and vigour are not enough, and are infertile or newborn few.

Gecko: claim again that clam is separated, clam Eriocheir sinensis, gecko, celestial toad, Taiwan is called big Gekko Swinhonis, the Latin title: Gekko gecko; Gekkonidae; Terrestrial reptile, English name Tokay mainly is distributed near the subtropical zone of the Asia tropic of cancer; Comprise China, Vietnam, Thailand and Laos, have the kidney tonifying tonifying the lung; Dingchuan antitussive effect, " detailed outline ": former times the people's words drugs with tonic function being used for the debility, the genus of Radix Ginseng, Carnis caprae seu ovis.Gecko tonifying the lung gas, Dingchuan is quenched the thirst, the same Radix Ginseng of merit, tonifying YIN blood, it is thin to help essence to hold up, the same Carnis caprae seu ovis of merit.Control modern times a little less than the strain flaccidity, Xu Shuwei is controlled and is quenched one's thirst, and all uses it, all gets its nourishing also.Liu Chunyun, gas-liquid declines, cloudy Sanguis Draxonis person should use it.What Da Ying cloud, the Dingchuan antitussive, Mo Jia is in this." Bencao Jingshu ": Gecko, its main lung impairment and cough of a specified duration, pouring drop person, all the lung kidney is a disease, the labor utmost point then lung is suffered from a deficiency of the kidney and is given birth to heat, so exopathogen is prone to invade, internal evidence is held concurrently and is sent out also.Gecko belongs to cloudy, can moisturizing on the source, then the lung kidney all institute is supported, and consumptive fever is coughed and is removed certainly; The convergence of vessels in the lung, regulating fluid apssage, following defeated bladder, normal lung-QI is so drench the dewatering road from leading to also." Haiyao Bencao, Oversea Materia Medica ": treat folding and hinder, gas on the main consumptive lung disease, spitting of blood cough." Japan hanako materia medica ": control lung qi, antitussive, and logical menstruation, following stranguria caused by urinary stone and control blood." Kaibao Bencao ": main impairment of the lung caused by overstrain of a specified duration, treat cough, following pouring drop, waterway.Amplification on Canon of Materia Medica: the tonifying the lung asthenia is coughed.Discover that through the inventor Gecko has certain effect to the function of protecting internal organs in preparation of the present invention.

Ramulus Cinnamomi: another name: Liu Gui, RAMULUS CINNAMOMI; Be Lauraceae aiphyllium plant; English name: Cassia Twig, Latin literary fame: Ramulus Cinnamomi [meridian distribution of property and flavor] is hot, sweet, temperature.GUIXIN, lung, urinary bladder channel (diaphoresis power is weak).[function cures mainly] diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.Be used for anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.

Fructus Jujubae: [another name] Fructus Jujubae, Fructus Jujubae, Chinese date, dried Fructus Jujubae, U.S. Fructus Jujubae, good Fructus Jujubae (" not Lu "), Fructus Jujubae (" Elementary Medicine "); [Latin] Chaenomeles sinensis, the fruit of Rhamnaceae xylophyta Fructus Jujubae; In the China's plantation in existing more than 8,000 year history, just classified as one of " five fruits " (peach, Lee, prunus mume (sieb.) sieb.et zucc., Fructus Pruni, Fructus Jujubae) since ancient times; Nutritional labelings such as Fructus Jujubae rich in proteins, fat, saccharide, carotene, vitamin B group, vitamin C, Citrin and calcium, phosphorus, ferrum and cyclic adenosine monophosphate.Wherein ascorbic content comes out at the top in fruit, and vitamin king's laudatory title is arranged.The modern pharmacological research of Fructus Jujubae shows that tool increases the effect of the cAMP in the leukocyte, has antiallergic action, protects the liver, increases the effect of muscular strength, calmness, hypnosis and blood pressure lowering.These all help life lengthening; Jujube polysaccharide is an active substance important in the Fructus Jujubae, and it has tangible complement activity and promotes the lymphopoiesis effect, but human body immunity improving power.Nature and flavor: fruit is sweet, temperature; Return spleen, stomach warp; Be used for weakness of the spleen and stomach, deficiency of QI in middle-JIAO, fatigue and lack of strength, anorexia and loose stool; The blood deficiency fistula is yellow, become thin, or the women is dirty dry, and spirit is uneasy.

The Chinese medicine preparation that the invention described above suppresses HIV is distinguished the flavor of by strengthening the body resistance side adds into, the Rhizoma Atractylodis Macrocephalae, and bitter, sweet, temperature has invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis effect.Modern pharmacological research confirms that the Rhizoma Atractylodis Macrocephalae has the effect of the HIV of inhibition.Other Chinese medicine plays effects such as improving immunity, opposing virus, protection internal organs, comprehensively plays to suppress virus and contaminate body, and dissipating blood stasis for subsidence of swelling goes aspects effects such as empty nourishing YIN, the mutual aid anti-stress, strengthens function such as hemopoietic function.

The Chinese medicine preparation of inhibition HIV of the present invention adds appropriate amount of auxiliary materials and processes corresponding dosage forms by the conventional formulation technology of relevant dosage form, and above-mentioned Chinese medicine preparation can be processed oral liquid, granule, capsule, tablet or other pharmaceutically useful dosage form.

The production method of the oral liquid of above-described inhibition HIV is: get the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Radix Codonopsis, Radix Rehmanniae Preparata, Fructus Lycii, Fructus Corni, Fructus Psoraleae, Radix Ophiopogonis, Ganoderma, Placenta Hominis, Ramulus Cinnamomi, Fructus Jujubae and Gecko 14 flavors by weight ratio; Add water 5-8 by gross weight and doubly decoct secondary; Each 2 hours, collecting decoction filtered; Add adjuvant, process oral liquid.

The production method of the granule of above-described inhibition HIV, capsule, tablet is: get the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Radix Codonopsis, Radix Rehmanniae Preparata, Fructus Lycii, Fructus Corni, Fructus Psoraleae, Radix Ophiopogonis, Ganoderma, Placenta Hominis, Ramulus Cinnamomi, Fructus Jujubae 13 flavors by weight ratio, add water 5-8 by gross weight and doubly decoct secondary, each 2 hours; Collecting decoction filters, and is concentrated into relative density and is 1.30 thick paste; Again dry below 80 ℃; Be ground into fine powder, adding grinds to form fine powder and sterilized Gecko powder, adds adjuvant; Mixing is processed granule, capsule or tablet.

The Chinese medicine preparation of above-described inhibition HIV can with the coupling of antiviral Western medicine, as the application in the treatment AIDS-treating medicine.

The Chinese medicine preparation of above-described inhibition HIV is tentatively on probation in clinical treatment AIDS project, and reflection is good, no obvious toxic-side effects.

 

Specific embodiment

Embodiment 1

Get 5 part of 13 flavor of 10 parts of the Radixs Astragali, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of the Radix Paeoniae Albas, 5 parts of Radix Codonopsis, 5 parts in Radix Rehmanniae Preparata, 5 parts of Fructus Lyciis, 5 parts of Fructus Corni, 5 parts of Fructus Psoraleaes, 5 parts of Radix Ophiopogonis, 10 parts of Ganodermas, 5 parts of Placenta Hominiss, 5 parts of Ramulus Cinnamomi, Fructus Jujubae and add water 5-8 by gross weight and doubly decoct secondary, each 2 hours, collecting decoction; Filter, be concentrated into relative density and be 1.30 thick paste, again dry below 80 ℃; Be ground into fine powder, add and to grind to form 15 parts in fine powder and sterilized Gecko powder, add adjuvant; Mixing is processed capsule.

Embodiment 2

Get 12 parts of the Radixs Astragali, 8 parts of the Rhizoma Atractylodis Macrocephalaes, 8 parts of the Radix Paeoniae Albas, 8 parts of Radix Codonopsis, 8 parts in Radix Rehmanniae Preparata, 10 parts of Fructus Lyciis, 10 parts of Fructus Corni, 10 parts of Fructus Psoraleaes, 10 parts of Radix Ophiopogonis, 15 parts of Ganodermas, 10 parts of Placenta Hominiss, 10 parts of Ramulus Cinnamomi, 10 parts in Fructus Jujubae and Gecko 14 flavors by gross weight add water 5-8 extraordinarily decocting boil secondary; Each 2 hours; Collecting decoction; Filter, add adjuvant, process oral liquid.

Embodiment 3

Get 10 part of 13 flavor of 15 parts of the Radixs Astragali, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of the Radix Paeoniae Albas, 10 parts of Radix Codonopsis, 10 parts in Radix Rehmanniae Preparata, 10 parts of Fructus Lyciis, 10 parts of Fructus Corni, 10 parts of Fructus Psoraleaes, 10 parts of Radix Ophiopogonis, 15 parts of Ganodermas, 10 parts of Placenta Hominiss, 10 parts of Ramulus Cinnamomi, Fructus Jujubae by gross weight add water 5-8 extraordinarily decocting boil secondary, each 2 hours, collecting decoction; Filter; Be concentrated into relative density and be 1.30 thick paste, dry below 80 ℃, be ground into fine powder again; Add and to grind to form 25 parts in fine powder and sterilized Gecko powder; Add adjuvant, mixing is processed tablet.

Embodiment 4

Get 15 part of 13 flavor of 30 parts of the Radixs Astragali, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts of the Radix Paeoniae Albas, 15 parts of Radix Codonopsis, 15 parts in Radix Rehmanniae Preparata, 15 parts of Fructus Lyciis, 15 parts of Fructus Corni, 15 parts of Fructus Psoraleaes, 15 parts of Radix Ophiopogonis, 20 parts of Ganodermas, 15 parts of Placenta Hominiss, 15 parts of Ramulus Cinnamomi, Fructus Jujubae by gross weight add water 5-8 extraordinarily decocting boil secondary, each 2 hours, collecting decoction; Filter; Be concentrated into relative density and be 1.30 thick paste, dry below 80 ℃, be ground into fine powder again; Add and to grind to form 30 parts in fine powder and sterilized Gecko powder; Add adjuvant, mixing is processed granule.

 

Clinical trial data

The present invention's 20 examples offer the Guangxi provincial hospital, and to carry out antiviral therapy treatment situation following.

One, clinical observation:

1. preparation for treating AIDS clinical symptoms of the present invention, sign situation of change (table 1):

Tcm clinical practice symptom, sign situation of change before and after this compound treatment of table 1

2. preparation for treating AIDS Carlow Paderewski integration situation of change of the present invention (table 2):

Carlow Paderewski integration situation of change before and after table 2 preparation for treating of the present invention

3. preparation for treating AIDS CD4 situation of change of the present invention (table 3):

CD4 situation of change (individual/μ l) before and after table 3 preparation for treating of the present invention

Two, model case:

Case 1:

Lee AIDSinfected patient, the company clerk, primary dcreening operation HIV is positive when erythra taking place in 2004, infects after confirmatory test is made a definite diagnosis HIV.Surveying cd4 cell counting at that time is 529, and body weight is 55kg, and begin to occur inappetence in August, 2008, dyspepsia, and spirit is poor, becomes thin, weak, spontaneous perspiration, easy catching a cold; 10 times every year on average, diarrhoea, average every day 5 times, watery stool, the time fear of cold, acid regurgitation arranged; Vomiting watery fluid, deep pulse is unable, and pale tongue with white fur is obeyed diarrhea certainly, and the commentaries on classics of not getting better is satisfied and is come hospital admission; Surveying the cd4 cell counting is 302, and body weight is 45kg, and the traditional Chinese medical science is examined to having loose bowels, and syndrome of yang deficiency of spleen and kidney gives this prescription and adds Fructus Psoraleae 20g, Semen Myristicae 15g; Fructus Schisandrae Chinensis 15, Fructus Corni 20g, treat 1 month altogether after, patient's appetite is greatly improved, spirit takes a turn for the better, from perspiration stopped; Symptom of diarrhea is clearly better, and defecate 2 average every day, embarks on journey, and body weight 52kg takes a good rest, and adheres to suitable exercise.Follow up a case by regular visits to in August, 2011, the patient catches a cold 3 times every year on average, and idol has diarrhoea, and surveying the cd4 cell counting is 459.

Case 2

AIDSinfected patient Zhang, the driver, in calendar year 2001 start injection take drugs, to inject 3 times in 1 day when frequent, have repeatedly and other people shared syringe behavior, primary dcreening operation HIV was positive when be in hospital because of hyperpyrexia for the end of the year 2006, infected after CDC confirmatory test in Guangxi district is diagnosed as HIV.Surveying the cd4 cell counting at that time is to begin to occur becoming thin in February, 568,2010, weak, spontaneous perspiration, easy catching a cold, average every month 1 time, clear urine in large amounts, sexual impotence, premature ejaculation; Can not normally carry out sexual life, the time fear of cold arranged, the time acid regurgitation is arranged, vomiting watery fluid, deep-slow pulse is unable, pale tongue with white fur; From the clothes Western medicine, the commentaries on classics of not getting better is satisfied and is come me to go to a doctor at the center, and surveying the cd4 cell counting is 216, and the traditional Chinese medical science is examined and is sexual impotence, syndrome of yang deficiency of spleen and kidney; Give this prescription and add Rhizoma Zingiberis 20g, Actinolitum 15g, Herba Epimedii 15g, Fructus Cnidii 15g, Rhizoma Polygonati 10g, Radix Rehmanniae Preparata 10g; Give doctor trained in Western medicine HAART treatment simultaneously, during the treatment, do not see obvious toxic-side effects, treat three months altogether after, patient's appetite is greatly improved, spirit takes a turn for the better; From perspiration stopped, the sexual impotence symptom is clearly better, can normally have sexual intercourse, and looks steadily it and adheres to taking antiviral drugs, takes a good rest, and adheres to suitable exercise.Follow up a case by regular visits to in June, 2011, the patient catches a cold, and surveying the cd4 cell counting is 405.

Clinical conclusion

Chinese medicine preparation of the present invention was used the first half of the year in 2011 and antiviral combination; Clinical effectiveness shows that Chinese medicine preparation of the present invention and antiviral Western medicine Combined application are after 6 months, except myalgia and menoxenia; Other symptom and signs all improve significantly; Wherein, weak, indigestion and loss of appetite, breathe hard and the curative effect of lumbago is superior to using merely antiviral agents, to the curative effect of other symptom and signs with merely with antiviral agents there are no significant difference.The effect that the Chinese medicine preparation of inhibition HIV of the present invention is described is superior to simple Western medicine antiviral therapy.

In sum; The Chinese medicine preparation of inhibition HIV of the present invention has the effect that improves AIDS related complex shape sign; That Chinese medicine and antiviral combination improve is weak, indigestion and loss of appetite, breathe hard and the effect of lumbago is superior to using merely antiviral agents, and does not have tangible untoward reaction with the antiviral agents Combined application.

Claims (5)

1. Chinese medicine preparation that suppresses HIV, it is characterized in that: this Chinese medicine preparation is processed by following parts by weight of traditional Chinese medicines raw material: Radix Astragali 10-30, Rhizoma Atractylodis Macrocephalae 5-15, Radix Paeoniae Alba 5-15, Radix Codonopsis 5-15, Radix Rehmanniae Preparata 5-15, Fructus Lycii 5-15, Fructus Corni 5-15, Fructus Psoraleae 5-15, Radix Ophiopogonis 5-15, Ganoderma 10-20, Placenta Hominis 5-15, Gecko 15-30, Ramulus Cinnamomi 5-15, Fructus Jujubae 5-15.

2. according to the Chinese medicine preparation of the described inhibition of claim l HIV, it is characterized in that: described Chinese medicine preparation is oral liquid, granule, capsule, tablet or other pharmaceutically useful dosage form.

3. according to the above-described production method that suppresses the Chinese medicine preparation of HIV of claim 1; It is characterized in that: get the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Radix Codonopsis, Radix Rehmanniae Preparata, Fructus Lycii, Fructus Corni, Fructus Psoraleae, Radix Ophiopogonis, Ganoderma, Placenta Hominis, Ramulus Cinnamomi, Fructus Jujubae and Gecko 14 flavors by weight ratio, add water 5-8 by gross weight and doubly decoct secondary, each 2 hours; Collecting decoction; Filter, add adjuvant, process oral liquid.

4. according to the above-described production method that suppresses the Chinese medicine preparation of HIV of claim 1, it is characterized in that: get the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Radix Codonopsis, Radix Rehmanniae Preparata, Fructus Lycii, Fructus Corni, Fructus Psoraleae, Radix Ophiopogonis, Ganoderma, Placenta Hominis, Ramulus Cinnamomi, Fructus Jujubae 13 flavors by weight ratio, add water 5-8 by gross weight and doubly decoct secondary; Each 2 hours, collecting decoction filtered; Be concentrated into relative density and be 1.30 thick paste, dry below 80 ℃, be ground into fine powder again; Add and grind to form fine powder and sterilized Gecko powder; Add adjuvant, mixing is processed capsule.

5. the purposes of the Chinese medicine preparation of inhibition HIV according to claim 1 is characterized in that: the application of this Chinese medicine preparation in preparation treatment AIDS-treating medicine.