CN103006809B - Traditional Chinese medicine decoction for treating systemic lupus erythematosus - Google Patents
Traditional Chinese medicine decoction for treating systemic lupus erythematosus Download PDFInfo
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Abstract
The invention relates to the field of pharmaceutical formulation, and in particular relates to a traditional Chinese medicine decoction for treating systemic lupus erythematosus. The traditional Chinese medicine decoction is characterized in that the bulk drug comprises the following components in parts by weight: 5-11 parts of tuckahoe, 8-14 parts of dodder, 5-11 parts of herba epimedii, 5-11 parts of Atractylis ovata, 8-14 parts of broom cypress fruit, 5-11 parts of codonopsis pilosula, 5-11 parts of Chinese thorowax, 6-12 parts of roasted liquorice, 6-12 parts of radix scutellariae, 6-12 parts of cornel, 5-9 parts of radix paeoniae rubra, 8-14 parts of southernwood, 8-14 parts of Eclipta alba, and 6-12 parts of rhizoma cimicifugae; and the 14 bulk drug ingredients are mixed, then soaked with water and decocted, and dregs are removed to obtain the filtrate. The traditional Chinese medicine decoction for treating systemic lupus erythematosus is low in cost and relatively high in treating effective rate, and has no obvious toxic side effect.
Description
Technical field
The present invention relates to a kind of Chinese patent medicine preparation, specifically a kind of Chinese medicine decoction of systemic lupus erythematosus nephritis.
Background technology
As everyone knows, lupus nephritis is a kind of common and serious complication of systemic lupus erythematosus (sle), mostly betides systemic lupus erythematosus (sle) and rises in after being ill 5 years.Systemic lupus erythematosus (sle) is a kind of autoimmune disease of complexity, involves multisystem, many organs.When systemic lupus erythematosus (sle) damages kidney, be lupus nephritis, as treated not in time and controlling, can finally develop into uremia, cause patient's death.At present, the method for the most general treatment lupus nephritis is exactly that glucocorticoid adds cell toxicity medicament cyclophosphamide, but because its side effect is more, application has clinically been subject to a lot of restrictions.
Summary of the invention
Object of the present invention is exactly, in order to overcome above-mentioned existing technical deficiency, to provide a kind of Chinese medicine decoction of systemic lupus erythematosus nephritis, and cost is low, there is no obvious toxic-side effects, treated effect is higher.
The technical scheme that the present invention solves the problems of the technologies described above employing is: a kind of Chinese medicine decoction of systemic lupus erythematosus nephritis, it is characterized in that, the weight portion of crude drug is, 5～11 parts, Poria, 8～14 parts of Semen Cuscutae, 5～11 parts of Herba Epimedii, 5～11 parts of the Rhizoma Atractylodis Macrocephalaes, 8～14 parts of the Fructus Kochiae, 5～11 parts of Radix Codonopsis, 5～11 parts of Radix Bupleuri, 6～12 parts of Radix Glycyrrhizae Preparata, 6～12 parts of Radix Scutellariaes, 6～12 parts of Fructus Corni, 5～9 parts of Radix Paeoniae Rubra, 8～14 parts of Herba Artemisiae Annuaes, 8～14 parts of Herba Ecliptaes, 6～12 parts of Rhizoma Cimicifugaes, 14 taste crude drug are soaked in water after mixing, the filtrate of removing slag to obtain after decocting.
The weight portion preferable range of each crude drug of the present invention is: 8 parts, Poria, 12 parts of Semen Cuscutae, 8 parts of Herba Epimedii, 8 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of the Fructus Kochiae, 8 parts of Radix Codonopsis, 8 parts of Radix Bupleuri, 10 parts of Radix Glycyrrhizae Preparata, 10 parts of Radix Scutellariaes, 10 parts of Fructus Corni, 7 parts of Radix Paeoniae Rubra, 10 parts of Herba Artemisiae Annuaes, 10 parts of Herba Ecliptaes, Rhizoma Cimicifugae 8.
The invention has the beneficial effects as follows, cost is low, there is no obvious toxic-side effects, treated effect is higher.
The specific embodiment
Below in conjunction with embodiment, the invention will be further described:
Embodiment 1:
Adopt Poria, Semen Cuscutae, Herba Epimedii, the Rhizoma Atractylodis Macrocephalae, the Fructus Kochiae, Radix Codonopsis, Radix Bupleuri, Radix Glycyrrhizae Preparata, Radix Scutellariae, Fructus Corni, Radix Paeoniae Rubra, Herba Artemisiae Annuae, Herba Ecliptae, Rhizoma Cimicifugae is that crude drug is prepared from, the every clothes of its component (weight portion) are 8 parts, Poria, 12 parts of Semen Cuscutae, 8 parts of Herba Epimedii, 8 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of the Fructus Kochiae, 8 parts of Radix Codonopsis, 8 parts of Radix Bupleuri, 10 parts of Radix Glycyrrhizae Preparata, 10 parts of Radix Scutellariaes, 10 parts of Fructus Corni, 7 parts of Radix Paeoniae Rubra, 10 parts of Herba Artemisiae Annuaes, 10 parts of Herba Ecliptaes, Rhizoma Cimicifugae 8, get 180 grams of mixing of above-mentioned 14 kinds of crude drug gross weights, by clean water, soak 1 hour, water consumption 1200ml, after intense fire is fried open, use slow fire boiling instead, extracting juice 200ml, two decoct and add water 300ml, decocting extracting juice 200ml, two decoct mixing, decoct again and be concentrated into 300ml, sterile vacuum packing, preparation gets product.Every day potion divide 2 times oral, each (medicine) being taken before meal 150ml sooner or later.
Poria of the present invention: sweet in the mouth, light, property is flat.Effect promoting diuresis to eliminate damp pathogen, spleen invigorating, calms the nerves.Cure mainly: for water damp syndrome, as dysuria, edema, stops drink, etc.; Semen Cuscutae: invigorating the liver and kidney, beneficial marrow, improving eyesight.Control soreness of waist and knee joint, seminal emission, quenches one's thirst; Herba Epimedii: acrid, sweet, warm, return liver, kidney channel.There is kidney-replenishing, bone and muscle strengthening, the effect of wind-damp dispelling; The Rhizoma Atractylodis Macrocephalae: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement; The Fructus Kochiae: clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching, for difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus; Radix Codonopsis: invigorating middle warmer, QI invigorating, promotes the production of body fluid.Control weakness of the spleen and stomach, deficiency of both QI and blood, fatigue and lack of strength, lack of appetite, thirsty, chronic diarrhea, proctoptosis.Control asthenia internal injury, intestinal cold in the stomach, the sliding chronic dysentery of rushing down, asthma excessive thirst; Radix Bupleuri: bitter in the mouth, cold nature.Return liver, gallbladder meridian.Have to evacuate and bring down a fever, soothing liver-QI, the function of yang invigorating.For cold, fever, alternate attack of chill and fever, malaria, distending pain in the chest and hypochondrium, menoxenia, uterine prolapse, the diseases such as proctoptosis; Radix Glycyrrhizae Preparata: spleen reinforcing stomach function regulating, Yiqi and vein recovery.For weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse; Radix Scutellariae: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst; Fructus Corni: meridian distribution of property and flavor: sour, puckery, tepor.Return liver, kidney channel.Function cures mainly: liver and kidney tonifying, essence astringing and desertion stemming.For vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating collapse; Radix Paeoniae Rubra: energy promoting blood circulation to restore menstrual flow, cool the blood dissipate blood stasis, heat-clearing and toxic substances removing.Cure mainly the diseases such as amenorrhea due to stagnation of blood, herpes simplex toxic swelling, postnatal blood stasis, heat in blood epistaxis, warm malicious macule; Herba Artemisiae Annuae: clearing away heat to improve acuity of vision, parasite killing.Zhi Fangre hectic fever due to YIN-deficiency, dysentery, malignant boil, scabies, rubella; Herba Ecliptae: sweet acid, cool.Enter kidney, liver.Stomach, intestine and small intestine.Control haematemesis, hemoptysis, epistaxis, hematuria, has blood in stool, dysentery, knife injury is hemorrhage, early whitening of beard and hair; Rhizoma Cimicifugae: meridian distribution of property and flavor: sweet, pungent, be slightly cold.Return spleen, stomach, lung, large intestine channel.Efficacy of drugs: deliver rash, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy.
Each raw material of the present invention also can according to the form below the embodiment that mixes of listed part by weight realize.Its processing technique is identical with embodiment 1.(unit: weight portion)
The clinical preliminary test carrying out below in conjunction with Wo Yuan，Ji In Shandong Weihai institute of traditional Chinese medicine is done further, is described in detail the present invention:
1, clinical data: the routine patient of clinical random selection 60, all patients are SLE nephritis.
2, Therapeutic Method: medicine potion every day of the present invention divide 2 times oral, each (medicine) being taken before meal 150ml sooner or later, serve on 90 days.
3, diagnostic criteria: a, Pathological prompt for IIb, III, IV, the V-type of WHO pathological; B, flesh creatinine clearance rate decline 30% in 1 year; C, twenty-four-hour urine protein quantification > 1g.Possess any one in above-mentioned three, should be thought of as lupus nephritis.As lack above-mentioned evidence, should possess 3 at least following: a, albumin < 3g/dl; B, albuminuria continue ++～++++; C, urine examination have liposome, hyaline cast, granular cast or red cell cast; D, persistent hematuria (5 erythrocyte/high power fields of >).Palpus eliminating other reasons is urinated the nephropathy due to disease, hypertension, medicine, infection etc. as warded off.
4, curative effect judgement: be divided into healing, effective, effective, invalid 4 ranks.Cure: symptom, sign and laboratory procuratorial work full recovery are normal, within 3 years, do not recur.Effective: symptom, sign disappear, and laboratory procuratorial work indices approaches normal.Or there is 80% index subjet to recover normal; Effective: symptom, sign are obviously improved, laboratory procuratorial work index makes moderate progress; Invalid: symptom, sign and laboratory procuratorial work index are unchanged or increase the weight of.
5, therapeutic effect: use the present invention to treat altogether 60 examples, cure 21 examples, effective 34 examples, effective 3, invalid 2 examples, total effective rate 97% (comprising healing, effective, effective).
Claims (2)
1. the Chinese medicine decoction of a systemic lupus erythematosus nephritis, it is characterized in that: the weight portion of crude drug is, 5～11 parts, Poria, 8～14 parts of Semen Cuscutae, 5～11 parts of Herba Epimedii, 5～11 parts of the Rhizoma Atractylodis Macrocephalaes, 8～14 parts of the Fructus Kochiae, 5～11 parts of Radix Codonopsis, 5～11 parts of Radix Bupleuri, 6～12 parts of Radix Glycyrrhizae Preparatas, 6～12 parts of Radix Scutellariaes, 6～12 parts of Fructus Corni, 5～9 parts of Radix Paeoniae Rubra, 8～14 parts of Herba Artemisiae Annuaes, 8～14 parts of Herba Ecliptaes, 6～12 parts of Rhizoma Cimicifugaes, 14 taste crude drug are soaked in water after mixing, the filtrate of removing slag to obtain after decocting.
2. a kind of Chinese medicine decoction of systemic lupus erythematosus nephritis according to claim 1, the weight portion that it is characterized in that said crude drug is, 8 parts, Poria, 12 parts of Semen Cuscutae, 8 parts of Herba Epimedii, 8 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of the Fructus Kochiae, 8 parts of Radix Codonopsis, 8 parts of Radix Bupleuri, 10 parts of Radix Glycyrrhizae Preparatas, 10 parts of Radix Scutellariaes, 10 parts of Fructus Corni, 7 parts of Radix Paeoniae Rubra, 10 parts of Herba Artemisiae Annuaes, 10 parts of Herba Ecliptaes, 8 parts of Rhizoma Cimicifugaes.
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| CN111700940B (en) * | 2020-07-31 | 2021-11-05 | 潍坊医学院附属医院 | Traditional Chinese medicine composition for treating maintenance stage lupus nephritis |
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Non-Patent Citations (2)
| Title |
|---|
| 慢性肾小球疾病的中医药治疗研究;钟文冠;《中国博士学位论文全文数据库》;20070110;第34-49页 * |
| 钟文冠.慢性肾小球疾病的中医药治疗研究.《中国博士学位论文全文数据库》.2007,第34-49页. |
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