CN104826077A - TCM (traditional Chinese medicine) preparation for psoriatic arthritis and preparing method thereof - Google Patents
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the field of TCM (traditional Chinese medicine) and discloses a TCM (traditional Chinese medicine) preparation for psoriatic arthritis, made from wooly datchmanspipe herb, snow lotus herb, safflower, medicinal cyathula root, tree peony bark, red peony root, common threewingnut root, white peony root, spreading hedyotis herb, humifuse Euphorbia herb, suberect spatholobus stem, baical skullcap root, garter snake, Chinese honeylocust spine, light yellow Sophora root, dried ginger, motherwort herb, honeysuckle stem, licorice root, and clematis root. According to their different features, the herbs are washed and sliced and pretreated, are then proportionally prepared and are finally made by the special means; the TCM preparation has the effects of dispelling wind and removing obstruction in the meridians, promoting blood circulation to arrest pain, invigorating blood to warm the middle warmer, and dredging and regulating collaterals; the composition of the TCM preparation and a making method thereof are unique; clinical tests show that the TCM preparation has evident efficacy, short therapeutic cycle, low cost, no adverse effect and any toxic or side effects and promising market application prospect.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, be specifically related to a kind of for psoriasis gonarthritis Chinese medicine preparation, the invention still further relates to the preparation method of this Chinese medicine preparation.
Background technology
Psoriasis arthropathica (psoriasis arthritsi, PA) has another name called arthropathic psoriasis (arthropathic psoriasis), is a kind of scorching arthrosis relevant to psoriasis.Psoriasis gonarthritis is the one of psoriasis arthropathica, and cardinal symptom is at knee joint position, and the primary disease course of disease is delayed, and easily recur, late origin ankylosis, causes maimed person.
The traditional Chinese medical science is thought, psoriasis arthropathica is many caused by wind-damp numbness, deficiency of the liver and kindey, though treatment primary disease method is many at present, great majority can only reach short-term clinical effects, and can not until recurrence.
There is no specificity or radical treatment method at present, western medicine is to primary disease mainly multiplex cell toxicity medicament, methotrexate, nonsteroidal antiinflammatory drug is treated, Most patients needs to take medicine for a long time or all the life, but this type of medicine of long-term taking or consumption improper, thyroid merit can be caused hyperfunction, cause obesity, edema, intestine gastric ulcer, feel sick, vomiting, dizzy, constipation etc. series of side effects symptom, and the dependency created, patient can be made to produce very large misery, therapeutic process again and again, DeGrain, expense is high, larger pressure at heart and ailing pressure is caused to patient.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine preparation for psoriasis gonarthritis, it is remarkable that this Chinese medicine preparation has therapeutic effect for treatment psoriasis gonarthritis, and healing time is short, cheap, has no adverse reaction and the feature of secondary toxic action.
Inventor is in clinical treatment practice for many years, and according to the law of development of this disease, and the combination principle of Chinese medicine, and by a large amount of clinical verifications, Exploration and conclusion goes out to be used for the treatment of the new formula of the Chinese medicine preparation of psoriasis gonarthritis repeatedly.The present invention has that therapeutic effect is remarkable, and healing time is short, cheap, has no adverse reaction and the feature of secondary toxic action.
The effect of Chinese medicine of the present invention:
Wherein:
Herba Aristolochiae Mollissimae: be the ground part of Aristolochiaceae herbaceous plant Aristolochia mollissima AristolochiamollissimaHance.Nature and flavor: pungent, bitter are flat.Return Liver Channel.Effect: dispelling wind and removing obstruction in the collateral, pain relieving.For rheumatic arthralgia, stomachache ， testis swells and ache, the diseases such as traumatic pain." decoction pieces is newly joined ": " loose migratory arthralgia, dredging collateral, controls pain all over the joints.
Herba Saussureae Involueratae: be Compositae Genus Saussurea plant Saussurea laniceps Saussurea laniceps Hand.-Mazz. and Saussurea eriocephala S. eriocephala Franch, be used as medicine with whole herb with root.Summer gathers, and Herb pulls up, and trembles clean silt, dries.Nature and flavor: sweet, micro-hardship, temperature.Effect: kidney invigorating and YANG supporting, regulating menstruation, hemostasis.For snow blindness, toothache, rheumatic arthritis, sexual impotence, menoxenia, metrorrhagia, leucorrhea; Wound hemorrhage is controlled in external.Record in " Chinese Herbal Medicine in Xinjiang handbook ": restore menstrual flow and invigorate blood circulation, bone and muscle strengthening, promote uterine contraction.
Flos Carthami: be the dried floral of feverfew Flos Carthami Carthamus tinctorius L..Nature and flavor: pungent, temperature.GUIXIN, Liver Channel.Effect: promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, injury from falling down, skin infection swells and ache." detailed outline ": invigorate blood circulation, moisturizes, pain relieving, loose swollen, stimulates the menstrual flow.
Radix Cyathulae: be the dry root of Sichuan amaranthaceous plant Radix Achyranthis Bidentatae Achyranthes bidentata Blume..Nature and flavor: bitter, sour are flat.Return liver, kidney channel.Effect: eliminating blood stasis and inducing menstruation, easing joint movement, inducing diuresis for treating stranguria syndrome.For amenorrhea lump in the abdomen, retention of placenta, arthralgia, flaccidity of the lower limbs clonic spasm of the muscle, hematuria stranguria with blood, injury from falling down.Record in " Traditional Chinese Medicine in Sichuan will ": expelling wind and removing dampness, stimulate the menstrual flow loose blood.Control cold-damp waist thigh bone pain, flaccidity of the lower limbs clonic spasm of the muscle, women's amenorrhea and lump in the abdomen, gonorrhea, hematuria, impotence, mistake are drowned.
Cortex Moutan: be the dry root bark of ranunculaceae peony Paeonia suffruticosa Andr..Nature and flavor: bitter, pungent, are slightly cold.GUIXIN, liver, kidney channel.Effect: clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.For maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, carbuncle sore tumefacting virus, falls and flutters the pain of injury.Record in " herbal classic ": main cold and heat, apoplexy Chi Zong, convulsion, infantile convulsion pathogen, except the hard blood stasis of disease stays house the intestines and stomach, settling five organs, treat carbuncle skin ulcer.
Radix Paeoniae Rubra: be the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall. or river Radix Paeoniae Rubra Paeonia veitchii Lynch.Nature and flavor: bitter, are slightly cold.Return Liver Channel.Effect: clearing away heat and cooling blood, eliminating stasis to stop pain.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, injury from falling down, carbuncle skin infection.TAO Hong-Jing is said: " the red person's minor benefit of Radix Paeoniae, custom side, with pain relieving, is do not subtract Radix Angelicae Sinensis.
Radix Tripterygii Wilfordii: be Celastraceae tripterygium plant Radix Tripterygii Wilfordii Tripterygium wilfordii Hook. f., is used as medicine with root, leaf, flower and fruit.Root is adopted autumn; Leaf is adopted summer; Flower, fruit Xia Qiucai.Nature and flavor: bitter, pungent, cool.Very toxic.Effect: dispel the wind, removing toxic substances, parasite killing.External treating rheumatic arthritis, skin is itched, and kills maggot, wriggler, water-snail eradication, malicious Mus.
The Radix Paeoniae Alba: be the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall..Nature and flavor: bitter, sour, are slightly cold.Return liver, spleen channel.Effect: suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat." herbal classic ": main pathogen stomachache, except arthralgia due to stagnation of blood, broken hard long-pending, control cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating.
Herba Hedyotidis Diffusae: be the herb of Rubiaceae plants of Hedyotis Herba Hedyotidis Diffusae Hedyotis diffusa Willd. [Oldenlandia diffusa (Willd.) Roxb.].Nature and flavor: sweet, light, cool.Be included into stomach, large intestine, small intestine meridian.Effect: heat-clearing and toxic substances removing, inducing diuresis to remove edema, promoting blood circulation and stopping pain.For acute appendicitis (appendicitis), furuncle toxic swelling, jaundice due to damp-heat, the diseases such as dysuria; Furuncle carbuncle is controlled in external, venom.Record in " Quanzhou book on Chinese herbal medicine ": heat clearing away dissipating blood stasis, eliminating carbuncle detoxifies.Control ulcer sores, scrofula.Again can lung heat clearing fire, eliminating the pathogens from the lung heat.Control lung-heat dyspnea with rapid and short breath, cough against uncomfortable in chest.
Herba Euphorbiae Humifusae: be the dry herb of euphorbia plant Radix seu Caulis Parthenocissi tricuspidatae Euphorbia humifusa Willd. or Herba Euphorbiae supinae Euphorbia maculata L..Nature and flavor: pungent are flat.Return liver, large intestine channel.Effect: heat-clearing and toxic substances removing, cooling blood for hemostasis.For dysentery, have loose bowels, hemoptysis, hematuria, has blood in stool, metrorrhagia, furuncle carbuncle.Record in " product remittance essence is wanted ": homophony gas and blood.
Caulis Spatholobi: be the dry rattan of leguminous plant spatholobus suberectus Spatholobus suberectus Dunn.Nature and flavor: bitter, sweet, temperature.Return liver, kidney channel.Cure mainly blood circulation promoting and enriching, menstruction regulating and pain relieving, relaxing muscles and tendons and activating QI and blood in the collateral.For menoxenia, dysmenorrhea, amenorrhea, rheumatic arthralgia, paralysis and numbness, blood deficiency and yellow complexion.
Radix Scutellariae: be the dry root of labiate Radix Scutellariae Scutellaria baicalensis Georgi.Nature and flavor: bitter, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Effect: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.Record in " herbal classic ": main all hot jaundice, intestinal Bleach, lets out profit, relieves oedema or abdominal distension through diuresis or purgation, and hematochezia closes, (controlling) malignant boil, and cellulitis is lost, acute scleritis.
Zaocys: be the dry body of Colubridae animal Zaocys Zaocys dhumnades (Cantor).Nature and flavor: sweet are flat.Return Liver Channel.Effect: dispel the wind, dredging collateral, relieving convulsion.For rheumatoid arthritis stubborn, numbness contracture, apoplexy facial hemiparalysis, hemiplegia, tic spasm, tetanus, leprosy scabies, scrofula malignant boil.
Spina Gleditsiae: be the dry Spina jujubae of leguminous plant Fructus Gleditsia Gleditsia sinensis Lam..Nature and flavor: pungent, temperature.Return liver, stomach warp.Effect: detumescence poison holding, evacuation of pus, parasite killing.For carbuncle from the beginning of or difficulty in discharging of pus; External treatment scabies leprosy.Record in " detailed outline ": control carbuncle, acute mastitis, scrofula caused by pathogenic wind malignant boil, retention of placenta, parasite killing.
Radix Sophorae Flavescentis: be the dry root of leguminous plant Radix Sophorae Flavescentis Sophora flavescens Ait..Nature and flavor: bitter, cold.GUIXIN, liver, stomach, large intestine, urinary bladder channel.Effect: heat clearing and damp drying, parasite killing, diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis.Record in " not Lu ": nourishing the liver courage, settling five organs, sedate benefit essence, sharp nine orifices, except latent heat intestinal Bleach, quenches the thirst, relieving alcoholic intoxication, and also, treat malignant boil bottom and hide, flat gastric qi, makes us addicted to food yellow urine.
Rhizoma Zingiberis: be the dry rhizome of zingiber Zingiber officinale Rosc..Nature and flavor: pungent, hot.Return spleen, stomach, kidney, the heart, lung meridian.Effect: Rhizoma Zingiberis warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant.For coldness and pain in the epigastrium, vomiting is had loose bowels, and cold extremities faint pulse, phlegm retention is breathed with cough.Record in " detailed outline ": Rhizoma Zingiberis, can draw that blood medicine enters blood system, gas medicine enters edema caused by disorder of QI.Can go again to dislike and support newly, have the meaning of Yin grows while yang is generating.
Herba Leonuri: be the fresh or dry aerial parts of labiate Herba Leonuri Leonurus japonicus Houtt..Nature and flavor: bitter, pungent, are slightly cold.Return liver, pericardium channel.Effect: promoting blood flow to regulate menstruation, inducing diuresis to remove edema.For menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria; Acute nephritis edema.
Caulis Lonicerae: be the dry stem branch of caprifoliaceae plant Radix Ophiopogonis Lonicera japonica Thunb..Nature and flavor: sweet, cold.Attach to the lung and stomach meridians.Effect: heat-clearing and toxic substances removing, dispelling wind dredging collateral.For epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle skin infection, beriberoid pyretic arthralgia, redness and swelling of joints burning pain.Record in " detailed outline ": control all rheumatism gas and all toxic swellings, carbuncle scabies, Fructus Myricae rubrae malignant boil, heat radiation removing toxic substances.
Radix Glycyrrhizae: be the dry root of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L..Nature and flavor: sweet, flat.GUIXIN, lung, spleen, stomach warp.Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Record in " not Lu ": warming the middle warmer and descending qi, stuffy sensation with restlessness is losed heart, and hinders dirty cough, quenches the thirst, qualcomm meridian, and sharp vim and vigour separate hundred poison of drug.
Radix Clematidis: be the dry root and rhizome of ranunculaceae plant Radix Clematidis Clematis chinensis Osbeck, Clematis hexapetala (mountain knotweed) Clematis hexapetala Pall. or northeast clematis (black common vetch) Clematis manshurica Rupr..Nature and flavor: pungent, salty, temperature.Return urinary bladder channel.Effect: expelling wind and removing dampness, removing obstruction in the collateral to relieve pain.For rheumatic arthralgia, numb limbs and tense tendons, the contracture of muscle arteries and veins, joint stuffiness, bone is choked with sobs larynx.Record in Tang Materia Medica: waist, kidney, foot knee joint, gather, all cold diseases of enteral, be not recovered for many years, the effect of clothes.
Side's solution of the present invention is: Herba Aristolochiae Mollissimae dispelling wind and removing obstruction in the collateral in side, Flos Carthami promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain, Radix Cyathulae eliminating blood stasis and inducing menstruation, Cortex Moutan blood circulation promoting and blood stasis dispelling, Radix Paeoniae Rubra eliminating stasis to stop pain, Radix Tripterygii Wilfordii is dispeled the wind removing toxic substances, and the Radix Paeoniae Alba, Herba Hedyotidis Diffusae are nourished blood pain relieving, Herba Euphorbiae Humifusae heat-clearing and toxic substances removing, Zaocys dispelling wind and removing obstruction in the collateral, above ten taste medicines, as monarch drug in side, are all returned Liver Channel, are had the effect of dispelling wind and removing obstruction in the collateral, promoting blood circulation and stopping pain.Psoriasis gonarthritis pathological changes endogenous cause of ill be between meridians and coagulation of QI-blood and do hotwork pain and cause primary disease.So dispelling wind and removing obstruction in the collateral, promoting blood circulation and stopping pain are the bases for the treatment of psoriasis gonarthritis, above ten taste medicines are monarch drug, and first fundamentally dispelling wind and removing obstruction in the collateral, promoting blood circulation and stopping pain makes disease obtain basic control.Herba Saussureae Involueratae invigorating kidney for regulating menstruation, Caulis Spatholobi blood circulation promoting and enriching, menstruction regulating and pain relieving, Rhizoma Zingiberis warming spleen and stomach for dispelling cold, recuperating depleted YANG are promoted blood circulation, and ministerial drug in the above three taste medicine sides of being, returns kidney channel.Auxiliary monarch drug dispelling wind and removing obstruction in the collateral, promoting blood circulation and stopping pain on the one hand; Another aspect has as ministerial drug warming middle-JIAO of invigorating blood circulation, regulating menstruation effect of promoting blood circulation.The pathogenic fire purging of Radix Scutellariae dampness, Spina Gleditsiae detumescence poison holding, Radix Sophorae Flavescentis heat clearing and damp drying, Herba Leonuri promoting blood flow to regulate menstruation, Caulis Lonicerae dispelling wind dredging collateral, Radix Clematidis dispelling wind and removing obstruction in the collateral, above Six-element medicine attaches to the lung and stomach meridians, and as adjuvant drug, causes the inducement of psoriasis gonarthritis from pathology treatment, dispelling wind and removing obstruction in the collateral, promoting blood circulation and stopping pain effect of the monarch and his subjects two medicine can be promoted as adjuvant drug, can promote that body is invigorated blood circulation warming middle-JIAO, regulating menstruation of promoting blood circulation by using corrigent the monarch and his subjects two medicine again.Radix Glycyrrhizae makes medicine as in side, has coordinating the actions of various ingredients in a prescription drug effect, effectively promotes that body is to the absorption of active ingredient.The all medicines of this side share, and the monarch and his subjects pull together, and assistant makes auxiliary altogether, have effect of effect of dispelling wind and removing obstruction in the collateral, promoting blood circulation and stopping pain, warming middle-JIAO of invigorating blood circulation, regulating menstruation of promoting blood circulation, can effectively treat psoriasis gonarthritis.
Another important feature of the present invention is that this Chinese medicine preparation contains abundant nutritional labeling, be rich in aminoacid and have more than 17 kinds, wherein essential amino acid has threonine, valine, methionine, isoleucine, leucine, lysine and phenylalanine, trace element containing needed by human has ferrum, chromium, copper, boron, manganese, strontium and zinc, several human body macroelement of another calcic, potassium, magnesium, phosphorus.Above nutritional labeling is all needed by human material, effectively can strengthen body immunity.
Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, each raw material dosage is for all to have good curative effect in following weight parts scope: Herba Aristolochiae Mollissimae 22-26 part, Herba Saussureae Involueratae 10-14 part, Flos Carthami 7-11 part, Radix Cyathulae 16-20 part, Cortex Moutan 8-12 part, Radix Paeoniae Rubra 18-22 part, Radix Tripterygii Wilfordii 10-14 part, Radix Paeoniae Alba 18-22 part, Herba Hedyotidis Diffusae 13-17 part, Herba Euphorbiae Humifusae 13-17 part, Caulis Spatholobi 22-26 part, Radix Scutellariae 8-12 part, Zaocys 8-12 part, Spina Gleditsiae 8-12 part, Radix Sophorae Flavescentis 18-22 part, Rhizoma Zingiberis 18-22 part, Herba Leonuri 28-32 part, Caulis Lonicerae 28-32 part, Radix Glycyrrhizae 4-8 part, Radix Clematidis 28-32 part.
Wherein be preferably: Herba Aristolochiae Mollissimae 24 parts, Herba Saussureae Involueratae 12 parts, 9 parts, Flos Carthami, Radix Cyathulae 18 parts, Cortex Moutan 10 parts, Radix Paeoniae Rubra 20 parts, Radix Tripterygii Wilfordii 12 parts, the Radix Paeoniae Alba 20 parts, Herba Hedyotidis Diffusae 15 parts, Herba Euphorbiae Humifusae 15 parts, Caulis Spatholobi 24 parts, Radix Scutellariae 10 parts, Zaocys 10 parts, Spina Gleditsiae 10 parts, Radix Sophorae Flavescentis 20 parts, Rhizoma Zingiberis 20 parts, Herba Leonuri 30 parts, Caulis Lonicerae 30 parts, 6 parts, Radix Glycyrrhizae, Radix Clematidis 30 parts.
A kind of preparation method of the Chinese medicine preparation for psoriasis gonarthritis is as follows:
Step one: by weight of the present invention, get the Radix Paeoniae Alba, parch, pulverizes, and crosses 120 mesh sieves, for subsequent use
Step 2: by weight of the present invention, gets Radix Tripterygii Wilfordii and puts into marmite, adds 3-4 times of volume water, intense fire infusion 40-50 minute, filter liquor, repeatedly infusion three times, merges three filtrates, for subsequent use;
Step 3: by weight proportion of the present invention, get Herba Aristolochiae Mollissimae, Radix Cyathulae, Cortex Moutan, Radix Paeoniae Rubra, Caulis Spatholobi, Radix Scutellariae, Zaocys, Spina Gleditsiae, Radix Sophorae Flavescentis, Rhizoma Zingiberis, Caulis Lonicerae, clematis chinensis medicinal materials be placed in marmite, add the water of 8 times of volumes, intense fire infusion 20-30 minute, again Herba Saussureae Involueratae, Flos Carthami, Herba Hedyotidis Diffusae, Herba Euphorbiae Humifusae, Herba Leonuri, Radix Glycyrrhizae are dropped in marmite, add 3 times of volume water, intense fire infusion 40 ~ 50 minutes, fiery infusion of larding speech with literary allusions obtains filtrate in 30 ~ 40 minutes, infusion merges gained filtrate three times repeatedly, for subsequent use;
Step 4: by step 2, three gained filtrates and the mixing of step one gained powder, stir evenly, is undertaken medicine soup concentrated adding ethanol, place precipitation, filter, abandon precipitation, filtrate recycling ethanol, it is the thick paste of relative density 1.15 ~ 1.20 under 75 DEG C of environment by gained concentration of liquid medicine, by air-dry for thick paste pulverizing, grinding, crosses 200 mesh sieves, dress affected part in right amount with vinegar during use, both the external pulvis for the treatment of psoriasis gonarthritis of the present invention.
Using method of the present invention: get powder, appropriate with vinegar, dress affected part, every day 2 times.It within 7 days, is a course for the treatment of.
Medicine of the present invention has the effect of dispelling wind and removing obstruction in the collateral, promoting blood circulation and stopping pain, warming middle-JIAO of invigorating blood circulation, regulating menstruation of promoting blood circulation, and good analgesic effect, cheap, have no side effect, easy to use, the mode that this Chinese medicine preparation adopts is treated and can be reduced the injury of Western medicine to patient body, alleviate the slight illness of patient, according to clinical 124 routine patient view statistics, use medicine of the present invention the total effective rate course for the treatment of 90.3%, two the total effective rate course for the treatment of 97.6%.
Detailed description of the invention
Embodiment one: Herba Aristolochiae Mollissimae 24 parts, Herba Saussureae Involueratae 12 parts, 9 parts, Flos Carthami, Radix Cyathulae 18 parts, Cortex Moutan 10 parts, Radix Paeoniae Rubra 20 parts, Radix Tripterygii Wilfordii 12 parts, the Radix Paeoniae Alba 20 parts, Herba Hedyotidis Diffusae 15 parts, Herba Euphorbiae Humifusae 15 parts, Caulis Spatholobi 24 parts, Radix Scutellariae 10 parts, Zaocys 10 parts, Spina Gleditsiae 10 parts, Radix Sophorae Flavescentis 20 parts, Rhizoma Zingiberis 20 parts, Herba Leonuri 30 parts, Caulis Lonicerae 30 parts, 6 parts, Radix Glycyrrhizae, Radix Clematidis 30 parts.
Embodiment two: Herba Aristolochiae Mollissimae 25 parts, Herba Saussureae Involueratae 11 parts, 9 parts, Flos Carthami, Radix Cyathulae 18 parts, Cortex Moutan 11 parts, Radix Paeoniae Rubra 21 parts, Radix Tripterygii Wilfordii 13 parts, the Radix Paeoniae Alba 20 parts, Herba Hedyotidis Diffusae 16 parts, Herba Euphorbiae Humifusae 14 parts, Caulis Spatholobi 24 parts, Radix Scutellariae 10 parts, Zaocys 10 parts, Spina Gleditsiae 11 parts, Radix Sophorae Flavescentis 21 parts, Rhizoma Zingiberis 21 parts, Herba Leonuri 31 parts, Caulis Lonicerae 30 parts, 7 parts, Radix Glycyrrhizae, Radix Clematidis 30 parts.
Embodiment three: Herba Aristolochiae Mollissimae 26 parts, Herba Saussureae Involueratae 13 parts, 10 parts, Flos Carthami, Radix Cyathulae 16 parts, Cortex Moutan 10 parts, Radix Paeoniae Rubra 21 parts, Radix Tripterygii Wilfordii 12 parts, the Radix Paeoniae Alba 21 parts, Herba Hedyotidis Diffusae 15 parts, Herba Euphorbiae Humifusae 14 parts, Caulis Spatholobi 23 parts, Radix Scutellariae 10 parts, Zaocys 10 parts, Spina Gleditsiae 10 parts, Radix Sophorae Flavescentis 20 parts, Rhizoma Zingiberis 21 parts, Herba Leonuri 31 parts, Caulis Lonicerae 31 parts, 8 parts, Radix Glycyrrhizae, Radix Clematidis 29 parts.
Just the clinical statistics data that patient uses medicine of the present invention below:
One, physical data
Accept out-patient 248 example for medical treatment, patient is divided into observation group and matched group at random, wherein male 160 example, women 88 example, M-F 1.8:1, max age 45 years old, minimal ages 30 years old, the course of disease time, not etc. every basic documents such as two groups of patient ages, sex, courses of disease were substantially not identical, no significant difference (P > 0.05).
Two, diagnostic criteria
Arthritis mostly occur after the psoriasis several years or curing psoriasis improper after, distally refers between (toe), and joint is involved the earliest, gradually involves knee joint.There is certain seasonality.X-ray shows: the swelling of early stage visible joint surrounding soft tissue; Affected joints distortion in late period, visible Dislocation and subluxation.Skin lesion is on the increase, color is red, sieve-like petechia is obvious.
Three, Therapeutic Method:
1, observation group is according to Medications Example one of the present invention, and weighting raw materials, by the treatment of invention implementation method, gets powder, appropriate with vinegar, dresses affected part, every day 2 times.It within 7 days, is a course for the treatment of.
2, matched group adopts conventional western medicine methotrexate for treatment method, and the Ureteral Calculus phase is 7 days.
Four, efficacy assessment standard:
1, cure: clinical symptoms disappears substantially, knee joint place psoriasis disappears, and joint recovers normal.
2, take a turn for the better: knee joint recovers normal substantially, and the external psoriasis clinical symptoms of knee joint alleviates to some extent.
3, invalid: clinical symptoms is with treating front no significant difference.
Five, therapeutic outcome statistics:
Matched group result is added up
Wherein: total effective rate=cure rate+improvement rate
Use the Comparison of therapeutic situation of this Chinese medicine preparation two groups of patients, two courses for the treatment of
Wherein: total effective rate=cure rate+improvement rate
Can find that observation group is apparently higher than matched group by the treatment total effective rate contrasting two groups of patients, illustrate thus, Chinese medicine of the present invention has good clinical effectiveness on treatment psoriasis gonarthritis, effectively can improve the cure rate for the treatment of, Be very effective, cheap, have no adverse reaction and any toxic and side effects, there is wide market application foreground.
Model case and curative effect:
Case one, patient Wang, man, 46 years old, people from Qingdao City, came here and goes to a doctor on January 18th, 2010.X-ray shows: periarticular soft tissues swelling, there is psoriasis for many years in joint, knee joint place, is diagnosed as psoriasis gonarthritis.Adopt made preparation in the embodiment of the present invention one, and selected preparation method, after two courses for the treatment of of treatment, effect is very good, and joint psoriasis disappears substantially, and joint function recovery is normal.
Case two, patient Lee, female, 39 years old, people from Linyi, Shandong.Come here on May 14th, 2010 to go to a doctor, symptom is as follows after diagnosing: there is psoriasis symptom for many years at knee joint place, periarticular soft tissues swelling, and treatment psoriasis for many years, has no improvement, causes arthritis on the contrary.Be diagnosed as psoriasis gonarthritis.Adopt made preparation in the embodiment of the present invention one, and selected preparation method, after two courses for the treatment of of treatment, effect is very good, and Effect of follow-up visit by telephone does not recur half a year.
Claims (4)
1. one kind for psoriasis gonarthritis Chinese medicine preparation, it is characterized in that, this Chinese medicine preparation is made up of the medicine of following weight portion: Herba Aristolochiae Mollissimae 22-26 part, Herba Saussureae Involueratae 10-14 part, Flos Carthami 7-11 part, Radix Cyathulae 16-20 part, Cortex Moutan 8-12 part, Radix Paeoniae Rubra 18-22 part, Radix Tripterygii Wilfordii 10-14 part, Radix Paeoniae Alba 18-22 part, Herba Hedyotidis Diffusae 13-17 part, Herba Euphorbiae Humifusae 13-17 part, Caulis Spatholobi 22-26 part, Radix Scutellariae 8-12 part, Zaocys 8-12 part, Spina Gleditsiae 8-12 part, Radix Sophorae Flavescentis 18-22 part, Rhizoma Zingiberis 18-22 part, Herba Leonuri 28-32 part, Caulis Lonicerae 28-32 part, Radix Glycyrrhizae 4-8 part, Radix Clematidis 28-32 part.
2. the Chinese medicine preparation for psoriasis gonarthritis according to claim 1, it is characterized in that, be made up of the medicine of following weight portion: Herba Aristolochiae Mollissimae 24 parts, Herba Saussureae Involueratae 12 parts, 9 parts, Flos Carthami, Radix Cyathulae 18 parts, Cortex Moutan 10 parts, Radix Paeoniae Rubra 20 parts, Radix Tripterygii Wilfordii 12 parts, the Radix Paeoniae Alba 20 parts, Herba Hedyotidis Diffusae 15 parts, Herba Euphorbiae Humifusae 15 parts, Caulis Spatholobi 24 parts, Radix Scutellariae 10 parts, Zaocys 10 parts, Spina Gleditsiae 10 parts, Radix Sophorae Flavescentis 20 parts, Rhizoma Zingiberis 20 parts, Herba Leonuri 30 parts, Caulis Lonicerae 30 parts, 6 parts, Radix Glycyrrhizae, Radix Clematidis 30 parts.
3. the Chinese medicine preparation for psoriasis gonarthritis according to claim 1 and 2, is characterized in that: described Chinese medicine preparation is external pulvis.
4. for a preparation method for the Chinese medicine preparation of psoriasis gonarthritis, it is characterized in that, preparation method is as follows: step one: by weight of the present invention, get the Radix Paeoniae Alba, parch, pulverizes, and crosses 120 mesh sieves, for subsequent use; Step 2: by weight of the present invention, gets Radix Tripterygii Wilfordii and puts into marmite, adds 3-4 times of volume water, intense fire infusion 40-50 minute, filter liquor, repeatedly infusion three times, merges three filtrates, for subsequent use; Step 3: by weight proportion of the present invention, get Herba Aristolochiae Mollissimae, Radix Cyathulae, Cortex Moutan, Radix Paeoniae Rubra, Caulis Spatholobi, Radix Scutellariae, Zaocys, Spina Gleditsiae, Radix Sophorae Flavescentis, Rhizoma Zingiberis, Caulis Lonicerae, clematis chinensis medicinal materials be placed in marmite, add the water of 8 times of volumes, intense fire infusion 20-30 minute, again Herba Saussureae Involueratae, Flos Carthami, Herba Hedyotidis Diffusae, Herba Euphorbiae Humifusae, Herba Leonuri, Radix Glycyrrhizae are dropped in marmite, add 3 times of volume water, intense fire infusion 40 ~ 50 minutes, fiery infusion of larding speech with literary allusions obtains filtrate in 30 ~ 40 minutes, infusion merges gained filtrate three times repeatedly, for subsequent use; Step 4: by step 2, three gained filtrates and the mixing of step one gained powder, stir evenly, is undertaken medicine soup concentrated adding ethanol, place precipitation, filter, abandon precipitation, filtrate recycling ethanol, it is the thick paste of relative density 1.15 ~ 1.20 under 75 DEG C of environment by gained concentration of liquid medicine, by air-dry for thick paste pulverizing, grinding, crosses 200 mesh sieves, dress affected part in right amount with vinegar during use, both the external pulvis for the treatment of psoriasis gonarthritis of the present invention.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105343568A (en) * | 2015-11-27 | 2016-02-24 | 赵婉治 | Medicine for treating dysmenorrhea |
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| CN101612293A (en) * | 2009-07-30 | 2009-12-30 | 周大红 | The psoriasic Chinese medicine composition of a kind of treatment joint type |
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| CN101612293A (en) * | 2009-07-30 | 2009-12-30 | 周大红 | The psoriasic Chinese medicine composition of a kind of treatment joint type |
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| CN105343568A (en) * | 2015-11-27 | 2016-02-24 | 赵婉治 | Medicine for treating dysmenorrhea |
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