CN105726734A - Liniment for treating cow mastitis and preparation method thereof - Google Patents
Liniment for treating cow mastitis and preparation method thereof Download PDFInfo
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K9/0041—Mammary glands, e.g. breasts, udder; Intramammary administration
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention provides liniment for treating cow mastitis.The liniment is composed of traditional Chinese medicine and adjuvant.The traditional Chinese medicine is prepared from, by weight, 13-17 g of galla chinensis, 18-22 g of rhizoma polygoni cuspidate, 23-27 g of flos carthami, 18-22 g of herba taraxac and 18-22 g of cortex phellodendri.The traditional Chinese medicine is preferably prepared from, by weight, 15 g of the galla chinensis, 20 g of the rhizoma polygoni cuspidate, 25 g of the flos carthami, 20 g of the herba taraxac and 20 g of the cortex phellodendri; a method for preparing the liniment for treating cow mastitis includes the steps that a traditional method is utilized to decoct traditional Chinese medicine, decocted fluid is contracted through a water bath method, supernate is taken and subjected to ethanol water bath purification, after sterilization is conducted, 0.3 mL of triethanolamine is added, a water solution is prepared, 3.5 g of glycerin monostearate and 3 g of vaseline are added to the water solution, water bath stirring is conducted at the temperature of 80 DEG C, a substance in the form of paste is made, then azone accounting for 5% the paste-formed substance, 1, 2-propylene glycol accounting for 10% the paste-formed substance and dimethyl sulfoxide accounting for 30% the paste-formed substance are added, stirring is conducted continuously till condensation is achieved, and the liniment is prepared.The liniment is directly applied to the sick area of the cow breast, targeted medicine application is achieved, and the liniment is quick in medicinal effect and good in effect.
Description
Technical field
The present invention provides a kind of liniment treating mammitis of cow and preparation method thereof
Background technology
At present, the method conventional at China's treatment mammitis of cow is injection of antibiotics, and majority takes associating use
The mode of medicine gives broad-spectrum antibiotic, causes pathogen to strengthen the drug resistance of antibacterials, treatment often occurs
Cycle stretch-out, dosage increase, and antibiotic remains in milk, serious appearance is failed to respond to any medical treatment and milch cow
The situation of eliminating.The method of the most useful treatment by Chinese herbs mammitis of cow, Chinese medicine is selected has heat-clearing and toxic substances removing, detumescence
The principal agent of mass-dissipating efficacy, can strengthen animal body immunologic function simultaneously, and be not likely to produce drug resistance, but at present,
Chinese medicine is generally administered orally or intravenous administration, it is impossible to reach the effect of target administration, so existing
The shortcoming that drug effect is low, therapeutic effect is poor.
Summary of the invention
It is an object of the invention to: a kind of liniment treating mammitis of cow and preparation method thereof, the present invention are provided
Liniment medicine can be made to play drug effect is fast, the metabolism cycle is short, therapeutic effect good, have no drug resistance.
The technical scheme is that the liniment for the treatment of mammitis of cow, it is characterised in that by Chinese medicine and auxiliary
Medicine forms, and wherein Chinese medicine is made up of the crude drug of following weight ratio: Galla Chinensis 13～17 grams, Rhizoma Polygoni Cuspidati 18～22
Gram, Flos Carthami 23～27 grams, Herba Taraxaci 18～22 grams, Cortex Phellodendri 18～22 grams.
Described Chinese medicine is made up of following preferred weight ratio crude drug: Galla Chinensis 15 grams, Rhizoma Polygoni Cuspidati 20 grams, red
Spend 25 grams, Herba Taraxaci 20 grams, Cortex Phellodendri 20 grams.
Prepare the liniment method of above-mentioned treatment mammitis of cow, have steps of: be soaked in water raw material of Chinese medicine
After 2～5 hours, decoct by traditional method, take decoction liquor, decoction liquor is put in 70 DEG C of water-baths concentration
To 150mL, then filtering, it is the ethanol of 95% that stirring adds content, and amount of alcohol added is the 60% of concentrated solution,
Standing 12～18 hours under 4 DEG C of environment, take supernatant, remove ethanol with 70 DEG C of water-baths, stirring addition contains
Amount is the ethanol of 95%, and amount of alcohol added is the 80% of concentrated solution, stands 12～18 hours under 4 DEG C of environment,
After filtration, remove ethanol with 70 DEG C of water-baths, gained supernatant adds purified water to 100mL, micro-with 0.25
The filter membrane in metre hole footpath carries out sucking filtration, steam sterilization at 121 DEG C, it is thus achieved that extracting solution；0.3mL is added in extracting solution
Triethanolamine, make mixed liquor, mixed liquor add 3.5 grams of glyceryl monostearates and 3 grams of vaseline,
80 DEG C of stirring in water bath, make paste, add the azone of paste 5%, the 1,2-PD of 10%, 30%
Dimethyl sulfoxide, be continuously stirring to condensation, prepare liniment.
The using method of the liniment that the present invention treats mammitis of cow is: the ill district of warm water cleaning cow breast,
After drying, the first milk in emptying milk Lac Bovis seu Bubali pond, the treatment mammitis of cow of the present invention is smeared in ill district
Liniment is appropriate, while smear, limit is massaged, each 20～30 minutes, every day 2 times, 1 course for the treatment of on the 7th.
The mechanism of action of the present invention is: under guidance of traditional Chinese medicine theory, according to the pharmacological property of each Chinese medicinal components
And mammitis of cow characteristics of incidence, in conjunction with years'experiences, filter out have eliminating stasis to stop pain, heat-clearing and toxic substances removing,
The raw material of Chinese medicine of removing heat from blood detumescence, utilizes the medicines such as Effect of Chinese Medicine Qing thermal detoxification, dispersing swelling and dissipating binds, enhancing human body immunity function
Reason effect, in cow breast ill district wiping so that it is effective ingredient can arrive directly, rapidly disease sites,
Reach target administration purpose.
In the present invention, the property of medicine of executed Chinese medicine is described as follows:
Galla Chinensis, astringes the lung, hidroschesis, astringing intestine to stop diarrhea, hemostasis and detoxicating functions, also has convergence and antibacterial action.
Rhizoma Polygoni Cuspidati, has dampness removing jaundice eliminating, heat-clearing and toxic substances removing, eliminating stasis to stop pain, effect of relieving cough and resolving phlegm.
Flos Carthami, has promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain, blood circulation promoting and blood stasis dispelling, and wet dissipation goes the effect swollen.
Herba Taraxaci, has the effects such as diuresis, cathartic, jaundice eliminating subcutaneous ulcer, function of gallbladder promoting.
Cortex Phellodendri, has heat clearing and damp drying pathogenic fire purging except steaming, effect of detoxification sore treatment.
Wherein mammitis of cow pathogen is played antibacterial and effect of suppression pathogen diffusion by Galla Chinensis；Rhizoma Polygoni Cuspidati
Flos Carthami swelling position, mastitis disease Lac Bovis seu Bubali district is played stimulate the menstrual flow, dissipating blood stasis and analgesic efficacy, and there is collaborative work
With；Rhizoma Polygoni Cuspidati, Cortex Phellodendri and Galla Chinensis have antipyretic and antidote functions, to treatment mastitis disease Lac Bovis seu Bubali district's skin temperature rise
There is certain effect, pathogen toxin is had function of detoxification simultaneously；Diuresis effect of Herba Taraxaci plays promotion
The effect that toxin is discharged, plays a protective role to liver, gallbladder simultaneously.
The invention have the advantage that and directly smear liniment in the ill district of cow breast, reach target administration, energy
Medicine can be made to play, and drug effect is fast, the metabolism cycle is short, therapeutic effect good, and principal agent uses Chinese medicine, have no drug resistance,
Having no side effect, liniment is easy to use, low cost, non-stress, drug residue free；Actual efficacy is seen
Examining result of the test to confirm, liniment of the present invention is responded well to treatment soon for mammitis of cow, and determined curative effect is nontoxic
Side effect, safety is good, is the preferred version for the treatment of mammitis of cow topical transdermal.70 DEG C of water-bath energy
Moisture content is vapored away under conditions of the non-volatile property of medicine.Azone, dimethyl sulfoxide belong to penetrating agent, have promotion medicine
The effect of thing Transdermal absorption.1,2-PD belongs to wetting agent, keeps paste medicament humidity after skin is embrocated,
It is dried after preventing ointment from embrocating, makes ointment drug action more longlasting.Glyceryl monostearate and the work of vaseline
With being the paste that the mixed liquor of aqueous phase is become oil phase.Triethanolamine has emulsifying, moisturizing, is humidified, increases
Thick effect, soluble in water, triethanolamine is emulsifying agent conventional in cream preparation, and another triethanolamine is with high
The gel phase good stability that level fatty acid is formed, can make constant product quality.
Detailed description of the invention
Embodiment one:
Relate to equipment: rotary evaporator, condensing unit, electronic balance, refrigerator, water-bath, centrifuge,
Filter, agitator and various containers etc..
Liniment and preparation method thereof for the treatment of mammitis of cow, concrete steps: prepare following raw material of Chinese medicine: five
Gall nut 13 grams, Rhizoma Polygoni Cuspidati 18 grams, 23 grams of Flos Carthami, Herba Taraxaci 18 grams, Cortex Phellodendri 18 grams；
Be soaked in water raw material of Chinese medicine 2～after 5 hours, and water did not had raw material of Chinese medicine, traditional method to decoct,
Decocting 3 times, the 1st time 1 hour, the 2nd, 3 times was respectively 30min, and the backflow distilled out is reclaimed in condensation every time,
Backflow is incorporated in three decoction liquor, takes decoction liquor, 70 DEG C of water-baths of decoction liquor are concentrated into 150mL, mistake
After filter, it is the ethanol of 95% that stirring adds content, and amount of alcohol added is the 60% of concentrated solution, after being sufficiently stirred for,
Under 4 DEG C of environment, stand 12～18 hours or refrigerated overnight, be centrifuged 5min with centrifuge 3000r/min, take supernatant
Liquid, removes ethanol with 70 DEG C of water-baths, and after ethanol is removed in volatilization, it is the ethanol of 95% that stirring adds content, second
Alcohol addition is the 80% of concentrated solution, after being sufficiently stirred for, stands 12～18 hours or cold preservation under 4 DEG C of environment
At night, after filtration, remove ethanol with 70 DEG C of water-baths, gained supernatant adds purified water to 100mL, make solution
It is 1 gram/mL containing crude drug amount, carries out filter sucking filtration with the filter membrane of 0.25 micron pore size, use vacuum filtration method,
Steam sterilization at 121 DEG C, it is thus achieved that extracting solution；In extracting solution, add the triethanolamine of 0.3mL, make mixed liquor,
In mixed liquor, add 3.5 grams of glyceryl monostearates and 3 grams of vaseline, 80 DEG C of stirring in water bath, make paste,
Add the azone of paste 5%, the 1,2-PD of 10%, the dimethyl sulfoxide of 30%, be continuously stirring to cold
Solidifying, it is thus achieved that a liniment, after bottling or bag, keep in Dark Place.
In the present invention, transdermal agent is added by operation instruction, and the oil phase adjuvant in liniment can also use stearic acid, stone
Wax etc. substitute, and promote that Drug Percutaneous Absorption can also use myristyl sodium sulfonate, menthol, decyl methyl sub-
Sulfones etc. substitute；If liniment viscosity is inadequate, a little Mel can be added to improve its viscosity.According to reality
Situation, can add required adjuvant, such as: disintegrating agent, lubricant, adhesive, transdermal agent, injection
Deng, it is prepared as oral agents or the injection of a kind of suitable Clinical Dosage Form；In preparation process, Rotary Evaporators can
Replace with the heating evaporation equipment with condensation recovery function.
Embodiment two:
Liniment and preparation method thereof for the treatment of mammitis of cow, prepares following raw material of Chinese medicine: Galla Chinensis 17 grams,
Rhizoma Polygoni Cuspidati 22 grams, 27 grams of Flos Carthami, Herba Taraxaci 22 grams, Cortex Phellodendri 22 grams；Remaining preparation method is with reference to embodiment
One, it is thus achieved that No. two liniments.
Embodiment three:
Liniment and preparation method thereof for the treatment of mammitis of cow, prepares following raw material of Chinese medicine: Galla Chinensis 15 grams,
Rhizoma Polygoni Cuspidati 20 grams, 25 grams of Flos Carthami, Herba Taraxaci 20 grams, Cortex Phellodendri 20 grams；Remaining preparation method is with reference to embodiment
One, it is thus achieved that No. three liniments.
The sick cattle suffering from mastitis in various degree is treated by liniment of the present invention, has cured over one hundred cow head,
Cure rate reaches more than 92%, provides below the treatment example that a few example is representative.
Treatment example one:
28 cow heads of certain cattle farm suffer from mastitis, utilize bovine subclinical mastitis detection liquid (BMT) right
Cattle only detects, BMT testing result: milk and the diagnosticum of sampling are separately added in diagnosis dish, shake
After, reactant is thickness hanging end, and color is yellow green；It is diagnosed as moderate milk according to the index change after detection
Cattle latent mammitis；Suffer from cattle performance: milk yield declines, and suffers from district's breast skin temperature rise, the most rubescent；
Therapeutic scheme: clean the ill district of cow breast with warm water, after dry towel is dried, in emptying breast pond
Milk；A liniment about 25mL is smeared in ill breast district, smears, while massage, uses after medication 20min
Warm water cleans, and every day treats at 7:00 point and 17:00 point, within one day, treats twice, treated for 1 course for the treatment of.
Therapeutic effect: carrying out vitro examination and BMT detection, result is as follows: the wherein newborn district of 28 cow heads
Skin rubefaction position disappears, and milk yield recovers former level substantially, and breast skin temperature recovers normal.BMT detects knot
Really: sending out in diagnosis dish and answering thing is homogenizing, flows without exception, the most orange.From testing result and clinical manifestation
On can be determined that 28 cow heads have recovered to health level.
Treatment example two:
7 cow heads of someone raiser find suffer from mastitis, detect by BMT method, and reactant is jelly
Thing, color is dark green, is diagnosed as severe bovine subclinical mastitis, suffers from cattle performance: milk yield declines, and suffers from district
Breast skin temperature rise, the slight swelling in local.
Therapeutic scheme: after cleaning suffers from the lesion of cattle, dry, empties milk；This No. two wipings are smeared in ill breast district
Agent about 30mL, smear, massage 30min after clean residual medicine, every day, chronotherapeutic twice, treated for 1.5 courses for the treatment of.
Therapeutic effect: vitro examination and BMT detection, result is as follows: wherein 6 skin turgors suffering from cattle disappear
Losing, other 1 is transferred to skin rubefaction by swelling, and the milk yield all suffering from cattle recovers former level, breast skin temperature
Recover normal.BMT testing result: sending out in diagnosis dish and answering thing is homogenizing, flows without exception, the most orange.
From testing result and clinical manifestation, can be determined that suffering from cattle for 6 gets well, remain 1 and suffer from Niu Jixu and control
Treat two days later, get well.
Treatment example three:
12 cow heads at certain milk cattle cultivating family, village find to suffer from mastitis in various degree, suffer from cattle clinical manifestation:
Suffering from rear milk area swelling on the left of cattle, breast district skin rubefaction, shinny, skin temperature rise, nipple swelling, under milk yield
Fall, has floccule, milk pinkiness in milk.
Therapeutic scheme: cleaning suffers from cattle disease district, with No. three liniments according to every patient's condition suffering from cattle, uses in right amount,
Smear, the massage time is 20～40 minutes, twice daily, treats 2 liang of courses for the treatment of.
Therapeutic effect: make a definite diagnosis on inspection, rear milk area, the left side swelling that 10 cow heads after healing occur disappears,
Skin recovers normal color, and Pi Wen recovers normal level, and nipple swelling disappears, and milk yield is recovered substantially, breast
Juice is creamy white, good fluidity；Remaining 2 cow head clinical manifestation: breast district's swelling alleviates, breast district skin face
Color recovers normal color, and Pi Wen recovers normal level, and nipple is micro-swollen, and milk yield has raised before relatively treating,
Milk is creamy white, has a little ziega, from checking that result can be determined that to suffer from have 10 to get well cattle,
2 symptoms alleviate.
Claims (3)
1. treat mammitis of cow liniment, it is characterised in that be made up of Chinese medicine and accessory drugs, wherein Chinese medicine by
The crude drug of following weight ratio is made: Galla Chinensis 13～17 grams, Rhizoma Polygoni Cuspidati 18～22 grams, Flos Carthami 23～27 grams,
Herba Taraxaci 18～22 grams, Cortex Phellodendri 18～22 grams.
The liniment for the treatment of mammitis of cow the most according to claim 1, it is characterised in that Chinese medicine by with
The crude drug of lower preferred weight ratio is made: Galla Chinensis 15 grams, Rhizoma Polygoni Cuspidati 20 grams, 25 grams of Flos Carthami, Herba Taraxaci 20 grams,
Cortex Phellodendri 20 grams.
3. treat the liniment method of mammitis of cow described in preparation claim 1 or 2, it is characterised in that tool
There are following steps: be soaked in water raw material of Chinese medicine 2～after 5 hours, decocts by traditional method, takes decoction liquor,
Decoction liquor being put in 70 DEG C of water-baths and be concentrated into 150mL, then filter, it is the second of 95% that stirring adds content
Alcohol, amount of alcohol added is the 60% of concentrated solution, stands 12～18 hours, take supernatant under 4 DEG C of environment,
Removing ethanol with 70 DEG C of water-baths, it is the ethanol of 95% that stirring adds content, and amount of alcohol added is concentrated solution
80%, under 4 DEG C of environment, stand 12～18 hours, after filtration, remove ethanol with 70 DEG C of water-baths, at gained
Supernatant adds purified water to 100mL, carry out sucking filtration with the filter membrane of 0.25 micron pore size, steam at 121 DEG C
Vapour sterilizing, it is thus achieved that extracting solution；In extracting solution, add the triethanolamine of 0.3mL, make mixed liquor, in mixing
Liquid adds 3.5 grams of glyceryl monostearates and 3 grams of vaseline, 80 DEG C of stirring in water bath, makes paste, then
Add the azone of paste 5%, the 1,2-PD of 10%, the dimethyl sulfoxide of 30%, be continuously stirring to cold
Solidifying, prepare liniment.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201610217059.5A CN105726734A (en) | 2016-04-08 | 2016-04-08 | Liniment for treating cow mastitis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610217059.5A CN105726734A (en) | 2016-04-08 | 2016-04-08 | Liniment for treating cow mastitis and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107951972A (en) * | 2017-11-27 | 2018-04-24 | 青岛农业大学 | Apply medicinal lotion or ointment outside a kind of Chinese traditional medicine composition for treating mastitis for milk cows thing and preparation method thereof |
| CN110538221A (en) * | 2019-09-09 | 2019-12-06 | 郑州百瑞动物药业有限公司 | Compound film spraying agent for dairy cows and preparation method thereof |
-
2016
- 2016-04-08 CN CN201610217059.5A patent/CN105726734A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 尹柏双等: "抗奶牛隐性乳房炎中草药透皮剂的临床疗效研究", 《黑龙江畜牡兽医》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107951972A (en) * | 2017-11-27 | 2018-04-24 | 青岛农业大学 | Apply medicinal lotion or ointment outside a kind of Chinese traditional medicine composition for treating mastitis for milk cows thing and preparation method thereof |
| CN110538221A (en) * | 2019-09-09 | 2019-12-06 | 郑州百瑞动物药业有限公司 | Compound film spraying agent for dairy cows and preparation method thereof |
| CN110538221B (en) * | 2019-09-09 | 2021-10-19 | 郑州百瑞动物药业有限公司 | Compound film spraying agent for dairy cows and preparation method thereof |
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