CN1927273A - Bath agent for influenza defervesce and preparing method thereof - Google Patents

Abstract

The invention provides a defervesce lotion for treating common cold and its preparing process, wherein the medicinal raw materials include root of Dahurain angelica 6-9 weight parts, ledebouriella root 8-12 weight parts, bupleurum root 12-18 weight parts, kudzuvine root 12-18 weight parts, plaster stone 20-30 weight parts, honeysuckle 20-30 weight parts, isatic root 12-18 weight parts, licorice root 4-6 weight parts and capsule of weeping forsythia 10-35 weight parts.

Description

A kind of bath agent for influenza defervesce and preparation method thereof

Technical field:

The present invention relates to a kind of bathing agent that is used for the treatment of influenza defervesce, the invention still further relates to the preparation method of this bath agent for influenza defervesce.

Technical background:

Fever is comparatively serious a kind of symptom after the flu, be attended by systemic pain unable, look very fragile, as treat untimely, can concurrent pneumonia (especially children's), myocarditis etc.The Chinese medicine of treatment cat fever is all very pained.Irritate to feed children's difficulty especially, must not be the sixth of the twelve Earthly Branches and for it approach through the digestive tract administration, people wish to develop other route of administration invariably, and percutaneous dosing treatment cat fever promptly is one of its method.

Skin is present in body surface, amassed at 1.5m by powder ²More than.Can be that horny layer and active epidermis enter corium by the epidermis approach, be entered blood circulation, also can pass through hair follicle by the blood capillary absorption, sebaceous gland, attached absorption of skins such as sweat gland or mucosa absorption also can absorb by the acupuncture point, directly the dredging the meridian internal organs.If with medicine in hot water, the horny layer of epidermis water content can increase to more than 50%, horny layer is behind hydration, be expandable into porous state, short texture is easy to medicine and penetrates, and therefore the percutaneous rate of medicine can increase 4-5 doubly, simultaneously skin temperature is increased to more than 37 ℃, the accelerate blood circulation.Though percutaneous dosing has differences such as race, individuality, age, sex, skin, generally speaking, the little people of children's, age to the good penetrability of medicine in the old people.And that umbilical part skin has a horny layer of epidermis is the thinnest, and barrier function is the most weak, subcutaneous fat-free mass, and skin and fascia, peritoneum characteristics such as directly link to each other help drug absorption most.Behind scrotum, the ear, body surface position such as groin, volume, oxter, scalp, the back of the body, foot, palm, forearm generally reduces successively to the absorbance of medicine.If people's integral body is immersed in the liquid medicine of heat certainly, allow whole skin be in full infiltration, blood flow is state fast, and its effect is best naturally.

Transdermal therapeutic sensation fever is the row's of giving interactive process in the heating bath, medicine enter body except that sterilize, kill the virus, the antiinflammatory, the bacterial virus secretions and the lysate thereof of while cylinder accumulation, the refuse that produces in the body tissue also percutaneous enters in the water fast.Be that an integral body conditioning is induced sweat, disperse process.Can be used as a kind of method of independent treatment cat fever, but also auxiliary internal administration is inside and outside and execute, and quickens the fever curative effect.

Summary of the invention:

One of purpose of the present invention is the problem that faced at present treatment cat fever Chinese medicine for oral administration medicine and the deficiency of Therapeutic Method thereof, and a kind of bath agent for influenza defervesce is provided; It is simple that two of purpose provides a kind of technology, the preparation method of this bath agent for influenza defervesce of handled easily.

One of purpose of the present invention can realize by following technical measures:

The medicinal raw material that this bath agent for influenza defervesce is made effective ingredient consists of: the Flos Lonicerae of the Radix Puerariae of the Radix Saposhnikoviae of the Radix Angelicae Dahuricae of 6-9 weight portion, 8-12 weight portion, the Radix Bupleuri of 12-18 weight portion, 12-18 weight portion, the Gypsum Fibrosum of 20-30 weight portion, 20-30 weight portion, the Radix Isatidis of 12-18 weight portion, the Radix Glycyrrhizae of 4-6 weight portion, the Fructus Forsythiae of 10-15 weight portion.

One of purpose of the present invention also can realize by following technical measures:

The medicinal raw material composition of making effective ingredient further is selected from: the Flos Lonicerae of the Radix Puerariae of the Radix Saposhnikoviae of the Radix Angelicae Dahuricae of 7 weight portions, 9 weight portions, the Radix Bupleuri of 16 weight portions, 14 weight portions, the Gypsum Fibrosum of 24 weight portions, 24 weight portions, the Radix Isatidis of 14 weight portions, the Radix Glycyrrhizae of 5 weight portions, the Fructus Forsythiae of 12 weight portions.

Two of purpose of the present invention can realize by following technical measures:

The preparation method of this bath agent for influenza defervesce is:

A. earlier the conventional decocting of raw material is boiled three times, kept 0.5-1.5 hour after boiling at every turn, three times filtrate merges;

B. the filtrate of a operation is concentrated into the 30-50% of raw material weight, send spray drying then or add earlier the dextrin of the 10-20% of raw material weight, under 55-80 ℃ of condition, dry again, after pulverize, pack product.

The present invention takes by weighing each Chinese medicine according to formula proportion and lumps together, and adds water to just after water cleans again and floods, and soaks 0.5-1.5 hour, through decocting, concentrate, oven dry or spray drying, pulverizing, pack product.Packing can be the 30g/ bag, also can be the 60g/ bag.This product have dispel the wind, expelling pathogenic factors from muscles, removing heat from blood, the function of its wind heat clearly.Be used for the hyperpyrexia that all cause because of diseases caused by exogenous pathogenic factor, headache limb Chu, diseases such as dysphoria and insomnia.Preparation technology of the present invention is simple, handled easily, and cost is low.

Raw material of the present invention:

Radix Saposhnikoviae: be the root of Umbelliferae herbaceos perennial Radix Saposhnikoviae Saposhnikovia divaricata (Ture2.) Schischk..

The Radix Angelicae Dahuricae: be the root of Umbelliferae herbaceos perennial Radix Angelicae Dahuricae Angelica dahurica (Fisch.ExHoffrn.) Benth.et Hook.f. or Radix angelicae dahuricae Angelica dahurica (Fisch.ex Hoffrm.) Benth.et hook.f.Var.formosana (Boiss.) Shan et Yuan.

Radix Bupleuri: be root or the herb of Umbelliferae herbaceos perennial Radix Bupleuri (Radix Bupleuri) Bupleurum chinensis DC and Radix Bupeuri Scorzonerfolii. (Radix Bupleuri Scorzonerifolii) Bupleurum scorzonerifolium Wild.

Radix Puerariae: be the root of Herba Gelsemii Elegantis Pueraria lobata (Wild.) Ohwi of the perennial defoliation liana of pulse family or Radix Puerariae rattan Pueraria thomsonii Benth..

Gypsum Fibrosum: be a kind of Ore, promptly contain water of crystallization calcium sulfate (CaSO ₄2H ₂O)

Flos Lonicerae: be the alabastrum of the perennial half normal edge prehensile bejuco Radix Ophiopogonis Lonicera japonica Thund. of Caprifoliaceae.

Radix Isatidis: be root or acanthaceous vegetable acanthaceous indigo Iris lacteal Pall.Var.chinensis (Fisch.) Koidz. rhizome and the root of cruciferae isatis Isatis indigodica Fort..

Fructus Forsythiae: be the fruit of Oleaceae machaka Fructus Forsythiae Forsythia suspensa (Thunb.) Vahl.

Radix Glycyrrhizae: be the root and rhizome of the bloated fruit of pulse family herbaceos perennial Radix Glycyrrhizae Glycyrrhiza uralensis Fisch., Radix Glycyrrhizae Glycyrrhiza inflate Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L..

Gypsum Fibrosum acrid in the mouth, sweet, Great Cold kind seasonal epidemic pathogens head disease, fever of the body, the three warmers skin heat controlled.Expelling pathogenic factors from muscles by diaphoresis is arranged, and the merit of the restlessness accompanied by ascending of QI of only quenching one's thirst for heavy prescription and specially reach the flesh table, is the key medicine of bringing down a fever; Radix Puerariae sweet in the mouth, suffering, cold have the merit of relieving muscles diaphoresis, the heat of taste clearly, Jiao's is clear positive in opening again, with Gypsum Fibrosum be we's monarch drug.Radix Saposhnikoviae, induce sweat, win the row whole body of wetting, dispel the wind, literary composition is arranged with the merit of making light of one's life by commiting suicide; Radix Bupleuri, expelling pathogenic factors from the exterior expel the heat-evil, and control heresy and go into cards such as alternate attack of chill and fever due to few positive half exterior and half interior; Radix Angelicae Dahuricae acrid in the mouth temperature, its pain relieving, sensible effect is particularly remarkable, and with Gypsum Fibrosum, Radix Saposhnikoviae is better with effect together, this medicine and Radix Saposhnikoviae, Radix Bupleuri is we's ministerial drug together altogether.The Flos Lonicerae antipyretic and antidote functions is rather good, has the effect of light a surname's evacuation; The heat of the kind diffusing part of the body cavity above the diaphragm housing the heart and lungs that clears away heart-fire of Fructus Forsythiae; The Radix Isatidis heat clearing away, removing heat from blood " big bright undergraduate course " " is controlled a day capable pyretic toxicity ".With Flos Lonicerae, Fructus Forsythiae is adjuvant drug altogether.The sweet mild and property of medicine of Radix Glycyrrhizae is messenger drug.Take a broad view of full side and dispel the wind, expelling pathogenic factors from muscles, removing heat from blood, its wind heat amounts to the effect of bringing down a fever clearly.

The main component of the used Chinese medicine of the present invention is all water-soluble, and these oral medicinal herbs are good with decocting.Bath agent for influenza defervesce of the present invention is dissolved in the water and infiltrates in the skin, so adopt decocting to extract to get best water-soluble effect.According to theory of Chinese medical science, the reason of external treatment is the reason of treatment by oral administration of medicines, and medicament soluble in water just can have good transdermal effect.So this preparation adopts extraction process by water.

Relevant this preparation The pharmacological results:

1, this preparation causes the influence of rat fever to beer yeast

With Wistar rat male and female half and half, be divided into matched group and administration group at random, weigh behind the labelling, the normal anus temperature of measurement 2-3 time (being generally 36.5-38 ℃) is averaged and is normal body temperature earlier, and every rat is measured an anus temperature from back subcutaneous injection 10% draft beer yeast suspension 3ml/kg every 1h, when treating 1 ℃ of left and right sides of fervescence (about 4-6h), rat respectively in the Mus frame of lucite, is placed on and soaked control group administered physiological saline 45 minutes containing in this preparation of 0.2g liquid medicine about 45 ℃.Moisture on the Mus body was dried in taking-up, surveyed an anus temperature every 30 minutes, and body temperature changes as following table:

This preparation causes influence (x ± SD) (n=8) of rat fever to beer yeast

Group	Normally	After the pyrogenicity	The body temperature variation (℃)
							After the administration (min)
			30	60	90	120
							The matched group experimental group	37.5±0.5 37.4±0.7	38.4±1.2 38.6±1.4	38.6±0.4 38.4±1.1	38.7±0.6 37.8±0.7	38.8±0.4 37.2±0.8**	39.0±0.5 37.2±0.9**

The injection of exogenous pyrexin is adopted in this experiment, body is produced and discharges endogenous pyrogen and causes rat temperature and raise, and experimental group and matched group compare the rat through this preparation bathing, and the statistical procedures significant difference illustrates that said preparation has significant refrigeration function.

2, the antibacterial action experimental result of this preparation

This experiment with staphylococcus aureus, Bacillus typhi, escherichia coli, sonne bacillus, bacillus pyocyaneus as experimental bacteria.Each bacterium is caused 6 culture dishs of few design, No. 1 plate adds every milliliter of medicinal liquid 2ml that contains said preparation 0.5g, other plates are respectively the medicinal liquid 2ml of 0.25g, 0.125g, 0.063g, 0.032g, 0.016g, adding the Carnis Bovis seu Bubali cream agar culture medium 18ml that has melted and be cooled to about 40 ℃ then in each plate shakes, make culture medium and medicinal liquid mixing, agar solidifies.The culture medium drug level is 0.05,0.025,0.0125,0.0063,0.0032 and 0.0016g/ml.

The above bacterial classification inoculation of preserving is cultivated 16-18h in Carnis Bovis seu Bubali cream fluid medium (not containing agar) in 37 ℃ of incubators, dip in respectively with inoculating loop and to get the zones of different of each experimental bacteria liquid with each pastille flat board of streak inoculation, put into 37 ℃ and cultivate the 24h taking-up, the growing state of different bacterium on the medicine flat board of variable concentrations sees the following form.

The antibacterial action of said preparation

Bacterial strain	Minimum inhibitory concentration (MK) (g/ml)
		Staphylococcus aureus e coli bacillus pyocyaneus Bacillus typhi sonne bacillus	0.0016 0.025 0.025 0.0125 0.0063

This experimental basis has asepsis growth or judges the antimicrobial spectrum and the minimum inhibitory concentration of medicine according to the antibacterial circle diameter size.From experimental result, this preparation has antibacterial action preferably.

3, the influence of increasing of the mouse skin capillary permeability due to this preparation xylol.Adopt kunming mouse (body weight 18-22g) male and female half and half, after the random packet, be placed on 40 ℃ respectively and contain in this preparation medicine of 0.1g water tumbler, make it expose head, water tumbler is incubated outward.The mice of another group is placed in 40 ℃ of normal saline respectively soaks 1h.Taking-up is dried, and injects 0.5% azovan blue normal saline solution 0.1ml/10g body weight in the tail vein.Immediately on the unhaired hide skin of position, mouse web portion center melted paraxylene 0.03ml/ only, mice takes off cervical vertebra and causes death after 20 minutes.Peel skin of abdomen and according to each blue speckle color and luster depth it is divided into 7-10 rank, 1 rank is remembered 1 fen.Every skin locus coeruleus is shredded input with operating scissors to be had in the plug teat glass, pour acetone-sodium sulfate extracting solution 10ml into, putting the dark place places, shake this test tube gently 2-3 every day, 2000rpm is centrifugal 10 minutes after 3 days, get supernatant in 590nm place colorimetric determination optical density, with the acetone-sodium sulfate liquid school zero of not steeping skin.Its experiment the results are shown in following table.

The influence that said preparation xylol induced mice capillary of skin permeability increases

Medicine	Dosage (g/kg)	Mus number (only)	The locus coeruleus color and luster depth (level)	Blue speckle amount of dye ug
					Normal saline said preparation said preparation	- 0.5 5	10 10 10	6.1±1.6 3.2±1.4** 2.1±1.0**	2.1±0.2 1.5±0.3** 1.0±0.2**

Dimethylbenzene is dripped in the mouse web portion skin of unhairing, because of its local irritant effect causes capillary permeability hyperfunction.After injecting the ivens orchid in intravenous, the ivens orchid promptly can go out from the vascular exosmosis in the hyperfunction blood capillary, form blue mottle piece in the position of melted paraxylene, how much can be used as of dyestuff seepage discharge judges whether medicine can the hyperfunction index of the early stage capillary permeability of inflammation-inhibiting.

The explanation of this experimental result, no matter be that the scoring of the blue speckle color and luster of the skin depth is compared, or compare to extract dyestuff spectrophotometric result, the numerical value of this preparation is starkly lower than the normal saline matched group, and it is hyperfunction to show that said preparation can obviously suppress dimethylbenzene induced mice skin of abdomen blood capillary official permeability.

This preparation is to 37 routine cat fever patients' observation of curative effect:

1, case sampling: selecting through diagnosis is 5 people in fever patient (in the Jinan City) 3-7 year of causing of flu, 18 people in 8-15 year, 11 people in 16-24 year, 3 people more than 24 years old.

2, using method: this preparation is dissolved in foot bath or 45 minutes-1h of bathing whole body (not adopting shower) in 40 ℃ of left and right sides warm water.

3, diagnostic criteria: mainly drop to index with body temperature.

More whether 1h after foot bath or the bathing surveys axillaty temperature and descends with the preceding body temperature of bubble.Later every 12h surveys body temperature once.Observe nasal obstruction simultaneously, whether the alleviating of the pain that fever causes.Special aversion to wind whether, be afraid of cool, headache etc.

4, criterion of therapeutical effect:

Invalid: do not bring down a fever behind the bubble, body temperature is constant

Effectively: bubble back body temperature descends

Produce effects: bring down a fever behind the bubble, do not go up, do not recur

5, efficacy result

1) 37 philtrums adopt 14 people that have of foot bath method, and foot bath once before sleeping every night

With body temperature ratio before the bubble	3-7 year 1 people	8-15 year 7 people	16-24 year 5 people	1 people more than 24	Sum 14 people
						Behind the bubble behind the 1h cooling bubble behind the 12h cooling bubble 2 produce effects persons of 24h cooling bubble steep 3 produce effects persons and steep 4 produce effects persons and steep produce effects person 5 times	1 1 0 0 1 0 0	7 6 4 2 4 1 0	5 5 4 1 3 1 0	1 0 0 0 0 1 0	14 12 8 3 8 2 0

The result shows 14 philtrums that adopt foot bath, compares bubble 1h body temperature with body temperature before the bubble and all descends, and wherein steeps cured person 3 people 2 times, steeps produce effects person 8 people 3 times, steeps produce effects person 2 people 4 times, steeps produce effects person 0 people 5 times, has a people to be reluctant to steep the 6th time again.

2) 37 philtrums adopt 23 people that have of bathing method, and bathing once before sleeping every night

With body temperature ratio before the bubble	3-7 year 4 people	8-15 year 11 people	16-24 year 6 people	2 people more than 24	Sum 23 people
						Behind the bubble behind the 1h cooling bubble behind the 12h cooling bubble 2 produce effects persons of 24h cooling bubble steep 3 produce effects persons and steep 4 produce effects persons and steep produce effects person 5 times	4 3 3 2 1 1 0	11 9 8 4 3 4 0	6 5 5 2 3 0 1	2 1 1 1 0 1 0	23 19 17 9 7 6 1

Adopt the philtrum of bathing, the body temperature of 1h after the bathing all has decline, and 12h and the 24h body temperature rise person that resurveys is few; 2 produce effects person 9 people of bathing, 3 produce effects person 7 people of bathing, 4 produce effects person 6 people of bathing, 5 produce effects person 1 people of bathing.

Criterion of therapeutical effect is a MAIN OUTCOME MEASURES with cooling and produce effects.But the children's bathing effect of this 37 philtrum below 7 years old is better than person more than 7 years old.The better effects if of sleeping immediately after all patient's bathings are intact.In the treatment no matter foot bath or bathing, nasal obstruction and whole body burn painful with the number of times that steeps increase and decrescence light.Wherein individual patient in treatment, obey other treatment flu is arranged antiinflammatory Western medicine (non-Chinese medicine) better effects if some.This illustrates that this preparation can be used as the complementary therapy of additive method.

Cat fever is an extremely complicated process, and having as individuality gently has heavily, and the foot bath condition all can satisfy, but the bathing condition is not necessarily so, can only select voluntarily according to the patient.Among this 37 routine patient, when having a routine foot bath also not fully recover for 5 times, abandon the foot bath method, produce effects person is 97%.Our system curative effect and method exploitativeness have been shown.

6, model case:

Open * *, the man, 7 years old, Shizhong District, Jinan pupil perspired to undress because of activity and suffers from cold existing 4 days of flu.Watery nasal discharge, the tonsil redness has slight cough, 38.5 ℃ of body temperature.Diagnosis is detested in food Chinese medicine for because of flu causes fever, gets this preparation to be dissolved in 40 ℃ of hot water, and under the adult looks after and keep water temperature, bathing 45 minutes, the 1h body temperature of sleeping is down replied normal, and repeating to survey body temperature during the 2nd day 12h is 37.5 ℃, and little have a rise.Fully recover after continuing bathing evening.

The specific embodiment:

Embodiment 1:

Take by weighing Radix Angelicae Dahuricae 6g, Radix Saposhnikoviae 12g, Radix Bupleuri 12g, Radix Puerariae 18g, Gypsum Fibrosum 20g, Flos Lonicerae 30g, Radix Isatidis 12g, Radix Glycyrrhizae 6g, Fructus Forsythiae 10g mixes, and adds water to just after water cleans again and floods, soaked 1.5 hours, and kept 0.5h after boiling, filter, repeat decocting again 2 times, three filtrates are merged; Be concentrated into 50% of raw medicinal material weight then; 10% the dextrin that adds raw medicinal material weight again, at last in 80 ℃ of oven dry, through pulverize product, press the 60g/ collation package.

Embodiment 2:

Take by weighing Radix Angelicae Dahuricae 9g, Radix Saposhnikoviae 8g, Radix Bupleuri 18g, Radix Puerariae 12g, Gypsum Fibrosum 30g, Flos Lonicerae 20g, Radix Isatidis 18g, Radix Glycyrrhizae 4g, Fructus Forsythiae 15g mixes, and adds water to just after water cleans again and floods, soaked 0.5 hour, and kept 1.5h after boiling, filter, repeat decocting again 2 times, three filtrates are merged; Be concentrated into 30% of raw medicinal material weight then; 20% the dextrin that adds raw medicinal material weight again, at last in 55 ℃ of oven dry, through pulverize product, press the 60g/ collation package.

Embodiment 3:

Take by weighing Radix Angelicae Dahuricae 7g, Radix Saposhnikoviae 9g, Radix Bupleuri 16g, Radix Puerariae 14g, Gypsum Fibrosum 24g, Flos Lonicerae 24g, Radix Isatidis 14g, Radix Glycyrrhizae 5g, Fructus Forsythiae 12g mixes, and adds water to just after water cleans again and floods, soaked 1 hour, and kept 1h after boiling, filter, repeat decocting again 2 times, three filtrates are merged; Be concentrated into 40% of raw medicinal material weight then; 15% the dextrin that adds raw medicinal material weight again, at last in 65 ℃ of oven dry, through pulverize product, press the 60g/ collation package.

Embodiment 4:

With embodiment 1,2 or 3, different be concentrating filter liquor after, directly send spray drying, the control inlet temperature is 180 ℃, outlet temperature is 75 ℃, after pulverize product, press the 30g/ collation package.

Claims (3)

1, a kind of bath agent for influenza defervesce is characterized in that the medicinal raw material of making effective ingredient consists of: the Flos Lonicerae of the Radix Puerariae of the Radix Saposhnikoviae of the Radix Angelicae Dahuricae of 6-9 weight portion, 8-12 weight portion, the Radix Bupleuri of 12-18 weight portion, 12-18 weight portion, the Gypsum Fibrosum of 20-30 weight portion, 20-30 weight portion, the Radix Isatidis of 12-18 weight portion, the Radix Glycyrrhizae of 4-6 weight portion, the Fructus Forsythiae of 10-15 weight portion.

2, bath agent for influenza defervesce according to claim 1 is characterized in that the medicinal raw material composition of making effective ingredient further is selected from: the Flos Lonicerae of the Radix Puerariae of the Radix Saposhnikoviae of the Radix Angelicae Dahuricae of 7 weight portions, 9 weight portions, the Radix Bupleuri of 16 weight portions, 14 weight portions, the Gypsum Fibrosum of 24 weight portions, 24 weight portions, the Radix Isatidis of 14 weight portions, the Radix Glycyrrhizae of 5 weight portions, the Fructus Forsythiae of 12 weight portions.

3, a kind of preparation method of bath agent for influenza defervesce as claimed in claim 1 is characterized in that:

A. earlier the conventional decocting of raw material is boiled three times, kept 0.5-1.5 hour after boiling at every turn, three times filtrate merges;

B. the filtrate of a operation is concentrated into the 30-50% of raw material weight, send spray drying or elder generation to add the dextrin of the 10-20% of raw material weight then, under 55-80 ℃ of condition, dry again, after pulverize, get product.