CN109731089A - A kind of composition and its preparation method and application adjusting liver-stomach disharmony - Google Patents
A kind of composition and its preparation method and application adjusting liver-stomach disharmony Download PDFInfo
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Abstract
The present invention provides the compositions that can adjust liver-stomach disharmony, including following component in parts by mass: 2~8 parts of turmeric, 1~4 part of rice bran fats alkanol, 50~70 parts of haw thorn extract, 20~40 parts of yam extract, 15~25 parts of Hericium erinaceus extract, 60~80 parts of smoked plum extractive, 7~14 parts of cassia seed extract, 30~50 parts of green-tea extract, 90~110 parts of compoiste fermented fruit vegetable powder.The present invention also provides the preparation methods of the preparation comprising the composition and preparation.Composition and preparation provided by the invention can improve liver-stomach disharmony, to adjust constitution, enhance mechanism ability, especially for liver-stomach disharmony type obesity, cooperate other conventional weight-reducing measures, can effective loss of weight, restore health.
Description
Technical field
The invention belongs to formulation products fields, are related to the adjusting of liver-stomach disharmony.
Background technique
Liver-stomach disharmony is a kind of by irritability stasis, perverse and unreasonable manner criminal stomach, stomach Qi rising caused disease of tcm.With modern medicine angle
Degree analysis, liver-stomach disharmony is the liver bile drainage difficulty due to caused by glucose -lipid metabolism disorder or direct stimulation, depressed emotion, is added
Weight gastric digestion burden, causes gastric emptying to extend, stomach turgor pain, can then cause belch, biliary tract siltation, reflux stomach
A series of symptoms of digestive tract such as inflammation, constipation.
In the age of past goods and materials scarcity, due to light few food, overwork impairment of yang, liver-stomach disharmony person often by mental element (such as
Depressed emotion) caused by, insufficiency of vital energy and blood, easily causes stagnation of liver qi, indigestion, the yellow thin type of depression of QI symptom in face in addition.With
The continuous development of society, glycolipid class intake is continuously increased in the universal dietary structure of Modern human populations, physical fitness steps up,
Qi and blood is full, but faces the quick change of knowledge and information, and rhythm of life is accelerated, and working strength continues to increase, setback and pressure
Etc. mood regulations are improper easily causes that the irritability stasis of blood is stagnant, does not dredge so that gastrointestinal tract is glutted；In addition qi and blood is vigorous, liver overnutrition,
Cause fatty liver, Abnormality of Glycolipid Metabolism type fat, namely what is often called " pressure-type is fat "；In addition, because biliary tract siltation caused by obesity,
The diseases such as gall stone can equally cause liver-stomach disharmony and its secondary symptom.Therefore, " the pressure-type fertilizer as caused by liver-stomach disharmony
It is fat " or the disease of digestive systems such as moss thin yellow, gastral cavilty, side of body rib turgor pain, belch, hiccup, acid regurgitation, loss of appetite, pass through routine
Weight-reducing, promote digestion means be difficult to realize expected effect.
Summary of the invention
The present invention based on TCM theory, develops a kind of composition that can adjust liver-stomach disharmony, so as to adjust by
This bring is unfavorable as a result, such as fat, disease of digestive system.
In the first aspect, the present invention provides a kind of composition, including following component in parts by mass: turmeric 2~8
Part, 1~4 part of rice bran fats alkanol, 50~70 parts of haw thorn extract, 20~40 parts of yam extract, Hericium erinaceus extract 15~
25 parts, 60~80 parts of smoked plum extractive, 7~14 parts of cassia seed extract, 30~50 parts of green-tea extract, compoiste fermented fruit vegetable powder
90~110 parts；Preferably, the composition includes following component in parts by mass: 5 parts of turmeric, 2 parts of rice bran fats alkanol,
60 parts of haw thorn extract, 30 parts of yam extract, 20 parts of Hericium erinaceus extract, 70 parts of smoked plum extractive, cassia seed extract 10
Part, 40 parts of green-tea extract, 100 parts of compoiste fermented fruit vegetable powder.
Preferably, each extract is that water mentions powder.
Preferably, the Curcumin In Curcuma mass content is 9%~11%, preferably 9.5%~10.5%；Rice bran rouge
The middle-and-high-ranking fatty alkyl alcohol mass content of fat alkanol is 78%~88%, preferably 80%~85%；Flavones matter in haw thorn extract
Measuring content is 1%~10%, preferably 3%；The withdrawal ratio of yam extract is 5:1~20:1, preferably 10:1；Hericium erinaceus mentions
The mass content for taking polysaccharide in object is 10%~50%, preferably 30%；The withdrawal ratio of smoked plum extractive is 5:1~20:1,
It is preferred that 10:1；The mass content of general anthraquinone is 1%~5% in cassia seed extract；The mass content of polyphenol in green-tea extract
For 10-98%, preferably 25%.
Said extracted object and extracting method are all general knowledge known in this field, and those skilled in the art as needed can milli
These extracts are obtained without difficulty.
In the second aspect, the present invention provides a kind of preparation, including effective component and auxiliary material, and wherein effective component is this hair
The bright composition, mass content in the formulation are 40%~45%, and the auxiliary material is acceptable auxiliary material on galenic pharmacy,
Including one of sweetener, fruit powder, essence, acidity regulator or a variety of.
Preferably, the sweetener includes oligofructose, oligoisomaltose, xylo-oligosaccharide, Sucralose, stevioside
One of glycosides, xylitol, antierythrite, isomalt, maltitol and D-sorbite are a variety of.
The fruit powder is any fruit powder, can use concentration of juices spray drying and is made, such as dark-plum juice powder.
The essence is the essence of any flavor, such as lemon powdered flavor；The acidity regulator is for citric acid and its often
Advise one of salt or a variety of.
Depending on the additive amount of auxiliary material can according to need.Those skilled in the art can suitably add according to specific requirement
Auxiliary material simultaneously produces the preparation.
Preferably, the preparation is drug, food or health care product.Preferably, the dosage form of the preparation is pulvis, particle
Agent, pill, tablet, capsule, paste, oral solution, preferably granule.
In the third aspect, the preparation method of preparation of the invention is provided, including weighing the effective component of formula ratio and auxiliary
Material, be uniformly mixed to get.
In the fourth aspect, the application of composition of the invention in the preparation of preparation conditioning liver-stomach disharmony is provided.
Further, the application of composition of the invention in preparation of the preparation for weight-reducing is provided.
Composition and preparation provided by the invention can improve liver-stomach disharmony, to adjust constitution, enhance mechanism ability, special
Be not that other conventional weight-reducing measures are cooperated for liver-stomach disharmony type obesity, can effective loss of weight, restore health.
Specific embodiment
Illustrate the present invention below in conjunction with specific embodiment, but the contents of the present invention are without being limited thereto.In following embodiment
Used medicinal material, reagent, instrument can be obtained by commercially available mode；Used method etc. is also this field routine side
Method, those skilled in the art's content according to specification can unambiguously implement the process and obtain accordingly result.
The present invention is based on health protection with Chinese medicine, it is believed that metabolism class caused by liver-stomach disharmony, digestion class illness, it should be with soothing the liver
Based on, supplemented by qi-regulating, while help with various modern, new resource food raw material be used for harmonizing stomach and lowering adverse Qi；Applicant has evaded Chinese medicine group
Non- integration of drinking and medicinal herbs, non-healthcare class Chinese medicine material in Fang Peiwu will be more by researchs such as prescription screening, dosage screening, effect screenings
Kind material composition carries out reasonable compatibility and obtains composition and preparation of the invention by many experiments, wherein
Cassia seed is sweet, bitter, salty, slightly cold, returns liver, large intestine channel, and sweet-salty is cold in nature, and energy clearing liver fire, enters large intestine channel and energy is clear
Hot relax bowel and defecation, consumer product dredge stasis.
Dark plum is sour, puckery, puts down, returns liver, spleen, lung, large intestine channel, Compendium of Material Medica carries its " (only) gastric disorder causing nausea is dysphagic ", sour to promote the production of body fluid
Quench the thirst, it also can digesting and appetizing.
Said two devices share, soothing liver-qi stagnation, hold back the fire of deficiency type, change body fluid, with for monarch.
Turmeric is pungent, bitter, and temperature returns liver, the spleen channel, and " Japan hanako materia medica " says its " only storm wind pain, cold air, lower food ", " herbal guiding principle
Mesh " cloud: " turmeric it is simultaneous enter spleen, it is simultaneous to control gas ", pungent scattered temperature is logical, hardship is let out, not only entered blood system and entered gas point, energy blood-activating and qi-promoting and relieve pain.
Chinese yam sweet and neutral, returns spleen, lung, kidney channel, Shennong's Herbal carry its " bowl spares, benefiting energy, long muscle ", can tonifying spleen benefit
Gas nourishes spleen yin, is chiefly used in deficiency-weakness of spleen-QI or deficiency of both qi and yin, thin out of strength, deficiency of food, loose stool.
Hawthorn acid, sweet, tepor, returns spleen, stomach, Liver Channel, " daily book on Chinese herbal medicine " call it " helping digestion product, row knot gas, the wide diaphragm of stomach invigorating disappear
Blood mass at the right hypochondrium block ", there is the function of promoting digestion and removing indigestion, scattered stasis.
Above-mentioned three's phase 5, can regulating qi-flowing for harmonizing stomach, disperse accumulationization is stagnant, promoting qi circulation and relieving pain, auxiliary monarch drug in a prescription reach dispersing stagnated hepatoqi function, with for
Minister.
Compoiste fermented fruit vegetable powder contains polymer substance (vegetable active enzyme, also known as " ferment with biocatalytic Activity
Element "), while containing there are many anti-inflammatory, antioxidant ingredient, can by remove liver free radical, exclude blood toxicity, participation and
The modes such as liver metabolism process are excited, have the function that nourishing the liver, protect liver.
Rice bran fats alkanol is new resource food, is one of rice bran associated depth converted products, and rice bran enters taste warp, Wang
Grain husk " food book on Chinese herbal medicine " claims it " can lead to intestines, appetizing, lower gas grinds block ".
Green tea is bitter, sweet, slightly cold, return heart, lung, stomach meridian, have refresh oneself clear away heart-fire, the weight-reducing of clearing away heat, relieving summer heat, promoting digestion and resolving phlegm, eliminating greasiness,
It promotes the production of body fluid to quench thirst, fall fire improving eyesight, stop dysentery dehumidifying and other effects, Compendium of Material Medica draws Chen Cangqi's speech " long food, make us thin, remove people's rouge ", draws
" legendary god of farming's cuisine canon " says " lower gas helps digestion ", modern medicine think its with anti-aging, diuresis, antiviral, lipid-loweringing, the medicines such as relieve fatigue
Reason effect.
Hericium erinaceus is sweet in flavor, mild-natured, can relieving the five internal organs, aid digestion." Drug Standard of Ministry of Public Health of the Peoples Republic of China " the 15th
Receipts have a Hericium erinaceus piece, carry and say " this product is the tablet that Hericium erinaceus is processed into, have effects that nourishing the stomach and in, for stomach, 12 fingers
The treatment of enterelcosis and chronic gastritis ".
Above-mentioned four share, feasible liver protection, lower gas, help digestion, nourishing the stomach the benefits of, it is mild-natured and, preferably improve, be for assistant make.
Zhu Pintong is used, play altogether soothing liver-qi stagnation, qi-regulating and in, the function of promoting digestion and nourishing stomach, be suitable for belonging to liver-stomach disharmony, it is stagnant in
The card person stopped, also feature is suitable for modern society and is referred to as " pressure-type " obese people.
Embodiment 1:
Meet each of corrresponding quality standard requirements according to each experimental example shown in table 1 and the purchase of the formula of comparative example or preparation
Ingredient is placed in clean area, spare.Wherein, each extract proposes method by water and obtains, and production method is as follows: taking raw material, adds
10 times of raw material gross mass water impregnate 1 hour, decoct 1.5 hours, and filtering obtains first pass extracting solution；Again plus 8 times of raw material are total
The water of quality decocts 1.5 hours again, and filtering obtains second time extracting solution, merges extracting solution twice.Extracting solution is dense through depressurizing
Contracting drying obtains corresponding raw material extract (water mentions powder), spare.
The manufacturer of compoiste fermented fruit vegetable powder in table 1 is big fellow's ferment biological Science and Technology Co., Ltd..
The amount of each ingredient is parts by weight in each experimental example, and content is mass content.
Table 1: pharmaceutical formulation
2) above-mentioned each ingredient is mixed 30 minutes；Mixed material is packaged machine filling, heating sealing, is closed through examining
Outer packing is carried out after lattice.
Test case 1:
Raise after diagnosing be 100 people of liver-stomach disharmony type subject, the age between 30-45 years old, male.4 groups are randomly divided into,
The preparation of above-mentioned experimental example 1 and 2, comparative example 1 and 2 is taken respectively.Once a day, each 8g, takes after mixing it with water.It takes two months, cooperates
Low-fat low-salt low suger diet, daily breakfast, lunch and dinner, seven points of every meal are full.Carry out following test.
Test one: swollen bored feeling of pain mitigation degree
Known from experience according to itself, compares the swollen bored feeling of pain before and after taking preparation, according to following scale: 5 points-obviously subtract
Gently, substantially without swollen bored feeling of pain；4 points-mitigate, there are also swollen bored feeling of pains once in a while；3 points-general level mitigates, and indistinctly has swollen bored
Feeling of pain；2 points-mitigation is unobvious, and swollen bored feeling of pain happens occasionally；1 point-with take before essentially unchangedization, it is even more heavy.
Statistics difference takes swollen bored feeling of pain mitigation degree score and corresponding number after different preparations, is shown in Table 2:
Table 2: swollen bored feeling of pain mitigation degree result
| Experimental example 1 | Experimental example 2 | Comparative example 1 | Comparative example 2 | |
| 5 points | 5 | 4 | 1 | 1 |
| 4 points | 16 | 14 | 5 | 3 |
| 3 points | 3 | 6 | 11 | 5 |
| 2 points | 1 | 1 | 6 | 11 |
| 1 point | 0 | 0 | 2 | 5 |
As seen from the above table, preparation of the invention being capable of substantially reduced swollen bored feeling of pain.
Test two: being irritable and getting angry easily phenomenon mitigates
The same unknown cause being irritable and getting angry easily phenomenon frequency of occurrences relatively taken before and after preparation, according to following scale: 5
Point-substantially reduced, it substantially will not being irritable and getting angry easily；4 points-mitigate, there are also being irritable and getting angry easilies once in a while；3 points-general level mitigates, but energy
Control being irritable and getting angry easily occurrence frequency；2 points-mitigation is unobvious, and being irritable and getting angry easily happens occasionally；1 point-with take before it is essentially unchanged
Change, it is even more heavy.
A situation arises for being irritable and getting angry easily phenomenon after statistics difference takes different preparations, is shown in Table 3:
Table 3: being irritable and getting angry easily phenomenon mitigation degree appraisal result
| Experimental example 1 | Experimental example 2 | Comparative example 1 | Comparative example 2 | |
| 5 points | 6 | 6 | 2 | 0 |
| 4 points | 13 | 15 | 6 | 4 |
| 3 points | 4 | 3 | 9 | 8 |
| 2 points | 2 | 1 | 5 | 6 |
| 1 point | 0 | 0 | 3 | 7 |
Seen from table 3, after taking preparation of the invention, the phenomenon that being irritable and getting angry easily, is substantially reduced.And combine table 2, experimental example 1
The subject overwhelming majority with 2 indicates that, since temper mitigates, swollen bored feeling of pain mitigates significantly, appetite also improves, and whole mood is steady
Fixed, body is light.
Test three: the variation of weight, body fat rate
Liver-stomach disharmony causes overweight, body fat rate height and the present invention to wish to solve the problems, such as.By taking the present invention
Preparation and cooperate loss of weight food and drink, detect the mitigation of weight and body fat rate and reduce situation.
Measured body weight: daily fixed work and rest, set time measurement, finally with before taking and take result after two months into
Row compares.
Table 4: weight loss amount result
| Weight loss amount (kg) | Experimental example 1 | Experimental example 2 | Comparative example 1 | Comparative example 2 |
| >4 | 1 | 1 | 0 | 0 |
| 3~4 (containing) | 8 | 10 | 1 | 0 |
| 2~3 | 13 | 12 | 5 | 7 |
| 1 (being free of)~2 | 2 | 2 | 11 | 13 |
| ≤1 | 1 | 0 | 8 | 5 |
Note: measurement error is considered, mitigation≤1kg is considered as unchanged.
By table 4 as it can be seen that taking the subject of 2 preparation of experimental example 1 and experimental example, weight loss clearly, has and actually subtracts
Weight effect is respectively 24 people and 25 people, accounts for the 96% and 100% of total number of persons, realizes the loss of weight effect of liver-stomach disharmony type obesity
Fruit.And loss of weight amount is appropriate, to body almost without adverse effect.
Body fat rate is calculated with taking measurement result that is preceding and taking after two months, and measurement and calculation are according to routine
Mode carries out.Body fat reduced rate is calculated using following formula:
(take preceding body fat rate-and take rear body fat rate)/take preceding body fat rate × 100%.
Table 5: body fat rate reduction amount result
| Body fat rate reduction amount | Experimental example 1 | Embodiment 2 | Comparative example 1 | Comparative example 2 |
| > 10% | 2 | 1 | 0 | 0 |
| 7%~10% (containing) | 6 | 6 | 0 | 0 |
| 4%~7% | 13 | 14 | 4 | 3 |
| 1% (being free of)~4% | 4 | 3 | 12 | 10 |
| ≤ 1% | 0 | 1 | 9 | 12 |
Note: considering measurement error, and mitigation≤1% is considered as unchanged.
Due to liver-stomach disharmony type patient's metabolic disorder, common loss of weight food and drink can not effectively lose weight and reduce body fat
Rate needs to solve liver-stomach disharmony situation from root.Take the preparation of the embodiment of the present invention 1 and embodiment 2 after two months, body
Rouge rate is substantially reduced, and has the body fat rate of part subject to revert to normal condition.
Test case 2:
Cleaning grade rat 80, male, quality (it is limited to tie up tonneau China experimental animal technology purchased from Beijing in 180~200g
Company), the free diet in experiment front and back, 12h light/dark condition, 22~25 DEG C of environment temperature raisings.
Rat is randomly divided into 4 groups, every group 20, is divided into Normal group, model control group, experimental group, contrast groups.
Modeling: method modeling is enraged using similar with Mental damage, depressed rage impairing the liver, there is food after making animal model
The indigestion symptoms such as depressed, appetite reduction are intended to, and without other organic diseases, can preferably reflect that Chinese medicine syndrome of incoordination between liver and stomach type is special
Point.
In addition to Normal group, other three groups of carry out modeling processing: at the big rat-tail distal end 1/3 of long sponge clamp, with
Not subject to broken skin, its violent rage is enabled, each 30s is stimulated, every 3h stimulation 1 time, 2 times a day.Clamp position is applied using 0.5% Iodophor
It wipes, avoids infection.Two forelimb of mouse and hind leg are bundled into placement respectively, every each 30min of mouse, one time a day.It is mated after loosening, greatly
Mouse looks for an opportunity to wrestle with other rats, enrages other rats, takes out after 30min, single cage breeding observing, continuous modeling 14 days.
Administration: Yu Zaomo the 7th day starts, and Normal group and model control group gavage physiological saline (2ml/kg), experiment
Group gavages the preparation (1g/kg can be configured to the suspension of 0.5g/ml concentration in advance) of experimental example 1, and contrast groups gavage comparative example 1
Preparation (1g/kg can be configured to the suspension of 0.5g/ml concentration in advance).1 time a day, continue 14 days.
Test one: general state observation
Observation is with the progress for enraging stress stimulation, the variation of rat weight and food-intake.Wherein, model control group and
Contrast groups are substantially reduced compared to Normal group；Experimental group is slightly lower relative to Normal group, is better than model control group and right
Compare group.
Test two: Intestinal propulsive rate detection
Gastrointestinal motility ability is detected using the method for prepared Chinese ink stomach-filling.
Prepare trophism semisolid paste: sodium carboxymethylcellulose 10g is dissolved in 250mL distilled water, be added milk powder 16g, sugar 8g,
Starch 8g, active carbon end 2g, grinding stir evenly, and are configured to the black semisolid paste of 300mL.Fasting after rat is administered 14 days
For 24 hours, quality is weighed, respectively stomach-filling semisolid paste 2mL/.Extracting vein blood after 40min, cervical dislocation put to death rat, open abdomen, remove
Small intestine out, measurement pylorus to ileocecum portion overall length and pylorus paste the distance in forward position to black semisolid.Intestinal propulsive rate=(deep and remote
Door to black semisolid paste forward position distance/pylorus to ileocecum portion overall length) × 100%.
For each group mean with one-way analysis of variance, P < 0.05 is to have significant difference.
Testing result is as follows:
Table 6: different preparations influence rat small intestine propulsion rate
| Group | Intestinal propulsive rate % |
| Normal group | 76.44±2.83 |
| Model control group | 41.25±2.97# |
| Experimental group | 68.67±3.26* |
| Contrast groups | 45.19±2.38 |
Note:#, compared with Normal group, P < 0.01；*, compared with model control group, P < 0.01
By result as it can be seen that model control group is compared with Normal group, Intestinal propulsive rate significantly reduce, illustrate modeling at
Function.Compared with model control group, Intestinal propulsive rate obviously increases experimental group, illustrates that preparation of the invention can restore small intestine push
Rate, i.e. improvement gastrointestinal motility ability.And contrast groups do not improve significantly, illustrating that the preparation of contrast groups does not play improves liver stomach
The effect of discord.
Claims (10)
1. a kind of composition, including following component in parts by mass: 2~8 parts of turmeric, 1~4 part of rice bran fats alkanol, hawthorn
50~70 parts of extract, 20~40 parts of yam extract, 15~25 parts of Hericium erinaceus extract, 60~80 parts of smoked plum extractive, certainly
7~14 parts of pine torch extract, 30~50 parts of green-tea extract, 90~110 parts of compoiste fermented fruit vegetable powder；Preferably, described respectively to mention
Taking object is that water mentions powder.
2. composition according to claim 1, wherein the composition includes following component in parts by mass: turmeric 5
Part, 2 parts of rice bran fats alkanol, 60 parts of haw thorn extract, 30 parts of yam extract, 20 parts of Hericium erinaceus extract, smoked plum extractive
70 parts, 10 parts of cassia seed extract, 40 parts of green-tea extract, 100 parts of compoiste fermented fruit vegetable powder.
3. composition according to claim 1 or 2, wherein the Curcumin In Curcuma mass content is 9%~11%,
Preferably 9.5%~10.5%；The middle-and-high-ranking fatty alkyl alcohol mass content of rice bran fats alkanol is 78%~88%, preferably 80%
~85%；Flavones mass content is 1%~10%, preferably 3% in haw thorn extract；The withdrawal ratio of yam extract is 5:
1~20:1, preferably 10:1；The mass content of polysaccharide is 10%~50%, preferably 30% in Hericium erinaceus extract；Dark plum extracts
The withdrawal ratio of object is 5:1~20:1, preferably 10:1；The mass content of general anthraquinone is 1%~5% in cassia seed extract；It is green
In tea extraction the mass content of polyphenol be 10-98%, preferably 25%.
4. a kind of preparation, including effective component and auxiliary material, wherein effective component is the described in any item combinations of claims 1 to 3
Object, mass content in the formulation are 40%~45%, and the auxiliary material is acceptable auxiliary material on galenic pharmacy, including sweetener,
One of fruit powder, essence, acidity regulator are a variety of.
5. preparation according to claim 4, wherein the sweetener includes oligofructose, oligoisomaltose, oligomeric wood
One of sugar, Sucralose, steviol glycoside, xylitol, antierythrite, isomalt, maltitol and D-sorbite
Or it is a variety of；The fruit powder is any fruit powder, preferably dark-plum juice powder；The essence is the essence of any flavor, preferably lemon powder
Essence；The acidity regulator is one of citric acid and its conventional salt or a variety of.
6. preparation according to claim 4 or 5, wherein the preparation is drug, food or health care product.
7. preparation according to claim 6, wherein the dosage form of the preparation is pulvis, granule, pill, tablet, capsule
Agent, paste, oral solution.
8. the preparation method of any one of claim 4~7 preparation, effective component and auxiliary material including weighing formula ratio are mixed
Close uniformly to get.
9. application of any one of claims 1 to 3 composition in the preparation of preparation conditioning liver-stomach disharmony.
10. application of any one of claims 1 to 3 composition in preparation of the preparation for weight-reducing.
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| CN108938873A (en) * | 2017-05-22 | 2018-12-07 | 俞有芳 | A kind of Weight-lossing antihypertensive oral solution and preparation method thereof |
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