CN103719866B - A kind of composition and use thereof, preparation method with effect of weight reducing - Google Patents
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- CN103719866B CN103719866B CN201410032178.4A CN201410032178A CN103719866B CN 103719866 B CN103719866 B CN 103719866B CN 201410032178 A CN201410032178 A CN 201410032178A CN 103719866 B CN103719866 B CN 103719866B
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The present invention uses for reference the Qinghai-xizang Plateau Region common people and tackles experience in unique dietary that unfavorable geographic climate formed, discloses a kind of composition with effect of weight reducing.Present composition raw material consists of kelp 15 parts ~ 45 parts, 10 parts ~ 30 parts, bent letter, rhizoma zingiberis 5 parts ~ 25 parts, sea-buckthorn 5 parts ~ 25 parts, myrobalan 5 parts ~ 15 parts.The present invention also provides composition preparing the application in health food and/or functional food and/or medicine, specifically possesses fat-reducing, weight reducing, fat reducing, the health food of body shaping class effect and/or functional food and/or medicine.The present invention also provides health food containing the present composition and/or functional food and/or medicine, and the preparation method of product.
Description
Technical field
The present invention relates to a kind of composition, particularly relate to a kind of composition and use thereof, the preparation method with effect of weight reducing.
Background technology
According to World Health Organization's definition, Simple obesity and overweight refers in human body can unhealthful exception in various degree or excess fat accumulation.World Health Organization's data information display, Simple obesity and overweight increases the weight of physical function burden, be the material risk factor suffering from NCD, its common health consequences comprises angiocardiopathy (mainly comprising heart disease and stroke), diabetes, musculoskeletal disorder, some cancer (endometrium, mammary gland and colon).Although Simple obesity and overweight is not counted as disease usually, when accumulation of fat exceedes and is to a certain degree then defined as obesity, seen as the mankind by World Health Organization and face a kind of chronic disease that the most out in the cold but incidence of disease sharply rising at present.
The bad climate environmental conditions such as the height above sea level of China Qinghai-xizang Plateau Region, air oxygen detrition, oxygen are thin produce larger burden to the physical function running of local resident and adjustment always.In such circumstances, if the burden increase level that health is overweight or obesity is run physical function is particularly serious.Qinghai-Tibet Platean resident is the unfavorable conditions of reply altitude environment, have accumulated in daily life diet a large amount of with regulate human body functional activity, maintain the relevant experience of body physiological health status, wherein also include and laying particular stress on the excessive accumulation controlling body fat under carnivorous dietary structure condition for a long time, preventing overweight, fat relevant diet experience.
Summary of the invention
Object of the present invention is exactly use for reference traditional Qinghai-Tibet diet experience to provide a kind of composition and method of making the same with effect of weight reducing.
For achieving the above object, technical scheme of the present invention is as follows:
There is a composition for effect of weight reducing, it is characterized in that: raw material consists of kelp 15 parts ~ 45 parts, 10 parts ~ 30 parts, bent letter, rhizoma zingiberis 5 parts ~ 25 parts, sea-buckthorn 5 parts ~ 25 parts, myrobalan 5 parts ~ 15 parts.
In above-mentioned composition, each component is:
Kelp is thallus or the Alariaceae plant of Laminariaceae plant sea-tangle (LaminariajaponicaArsch.), perennial kelp, keratin, and frond is divided into root shape holdfast, shank and sheet portion significantly, is olive-drab time ripe, pitchy after dry.Kelp is the conventional food materials that a kind of nutritive value is very high.Traditional view thinks that kelp nature and flavor are salty, cold; Return liver, stomach, kidney channel.Cure mainly softening and resolving hard mass, dissolving phlegm, Li Shui.For goiter and tumor, scrofula, testiclar gall, phlegm and retained fluid oedema.Modern chemical composition research display kelp is mainly containing phycocolloid acid, crude protein, sweet mellow wine, ash content, potassium, iodine.Confirm through pharmacology test, this product has step-down, hypoglycemic, and reducing blood lipid and anti-freezing, relieving asthma, hemostasis, anti-radiation, treats the thyroid function deficiency caused by iodine deficiency and waits effect.
Bent letter, another name Indian rhubarb, franzenbach rhubarb root and rhizome, oxtail seven, large rock seven are dry root and rhizomes of polygonaceae plant Radix Rhei emodi (RheumemodiWall.).Bent letter nature and flavor are bitter, cold; Return spleen, stomach, large intestine, liver the heart channel of Hang-Shaoyin.Purge heat logical intestines, and removing pattogenic heat from the blood and toxic material from the body, stimulates the menstrual flow by the stasis of blood.Modern chemical composition research display, rheum officinale is mainly containing anthraquinone glycoside and dianthracene ketone glucoside.Confirm through pharmacology test, this product has hemostasis, reducing blood lipid, anti-infective, and under rushing down, sharp liver, protects the effects such as courage.
Rhizoma zingiberis is the dry rhizome of zingiber (ZingiberofficinaleRosc.), is the most frequently used medicine and food raw materials, in diet, health care, have very important effect.Traditional medicine thinks that dry nature and flavor are pungent, hot; Return spleen, stomach, kidney, cardiopulmonary warp.Modern chemical composition research display rhizoma zingiberis is mainly containing Rhizoma Zingiberis oil volatile ingredient, also containing the peppery sulfonic acid of 6-ginger (6-gingesulfonicacid), 5-is outer-hydroxyl borneol-2-O-β-D-glucopyanoside (angelicoidenol-2-O-β-D-glucopyranoside) and ginger glycolipid (gingerglycolipid) A, B, C.Confirm through pharmacology test, rhizoma zingiberis has protection gastric mucosal cell, suppresses gastric acidity and secretion, reduces blood pressure, stimulate circulation, and suppresses the effects such as central nervous system.
Sea-buckthorn is the ripening fruits of Elaeangnaceae hippophae plant sea-buckthorn (Hippophaethibetana).It is conventional raw material in China's plateau food exploitation that sea buckthorn fruit contains abundant nutriment and bioactivator.Traditional view thinks that sea-buckthorn nature and flavor are sour, puckery, warm.Cough-relieving apophlegmatic, relieving dyspepsia, promoting blood circulation to remove blood stasis.For coughing with a lot of sputum, indigestion, dyspeptic abdominalgia, hemostasis through closing, fall flutter the stasis of blood swell.Modern chemical composition research display sea-buckthorn is containing the low glucoside of Isorhamnetin, Isorhamnetin-3-B-D-glycoside, Isorhamnetin-3-B-rutinoside, Mongolian oak chitin and Kaempferol.Confirm through pharmacology test, sea-buckthorn has and can reduce cholesterol, cures the effects such as angina pectoris, prevents and treats the effect of coronary atherosclerotic heart disease in addition; Have and eliminate the phlegm, cough-relieving, relieving asthma and treat the effect of chronic bronchitis; Can gastric duodenal ulcer and indigestion etc. be treated, evident in efficacy to illnesss such as chronic superficial gastritis, atrophic gastritis, colitis; Good therapeutic action is had to burn, scald, cutter burning, frostbite; Good result for the treatment of is had to cervical erosion.
Myrobalan is the dry mature fruit of combretaceae plant myrobalan (TerminaliachebulaRetz.) or fine hair myrobalan (TerminaliachebulaRetz.var.tomentellaKurt.).Its nature and flavor are bitter, sour, puckery, flat; Return lung, large intestine channel.The function that traditional medicine is recorded is that puckery intestines are astringed the lung with curing mainly, and falls fiery relieve sore throat.For rushing down protracted dysentery for a long time, prolapse of the anus of having blood in stool, the deficiency syndrome of the lung is breathed with cough, and coughs for a long time more than, pharyngalgia hoarsen.Modern chemical composition research display, the fruit of myrobalan is mainly containing tannin constituents, and major function is convergence and antidiarrheal, and clinical being mainly used in treats the diseases such as lobar pneumonia, bacillary dysentery pain, diphtheriaphor.
In the present composition, kelp, bent letter Main Function are hypoglycemic, blood fat, and play a major role to effect of composition, sea-buckthorn, rhizoma zingiberis play auxiliary fat-reducing efficacy, and myrobalan, by the effect of dropping, plays balance, nourishing, health-care effect.
Under optimum condition, combinations thereof raw material consists of kelp 30 parts, 20 parts, bent letter, rhizoma zingiberis 15 parts, sea-buckthorn 15 parts, myrobalan 10 parts.
The present invention also provides the purposes of above-mentioned composition: the composition that the present invention has an effect of weight reducing is preparing the application in health food and/or functional food and/or medicine.Specifically possess fat-reducing, weight reducing, fat reducing, the health food of body shaping class effect and/or functional food and/or medicine.
The present invention also provides health food containing above-mentioned composition and/or functional food and/or medicine.These health foods and/or functional food and/or medicine are based on oral type.
The present invention also provides the method for the above-mentioned health food of preparation and/or functional food and/or medicine, its technical scheme is: configured in proportion by each raw material components, traditionally patent medicine processing method, adds acceptable auxiliary material in pharmacy if desired and is prepared into different dosage form.Oral type can comprise solution, tablet, capsule, granule, powder etc.
Compared with prior art, beneficial effect of the present invention is: the present composition tests animal and clinical application test proof can reduce animal and human fatty tissue, is a kind of new compositions with effect of weight reducing; (2) present composition can be applied to health food and/or functional food and/or medicine; (3) present composition is for the preparation of health food and/or functional food and/or medicine, and preparation method is simple and easy to control; (4) present composition raw material is common conventional, safe and reliable in Tibet region.
Detailed description of the invention
Below in conjunction with embodiment, technical scheme of the present invention is further described.
Embodiment one
The present invention has the soup preparation method of the composition of effect of weight reducing.
1, raw material preparation
Present composition raw material is the material of integration of drinking and medicinal herbs, and preparing for avoiding raw material to be subject to seasonal restriction in embodiment, thus the medicinal material after only making all got by each raw material, and consumption is as shown in table 1 below:
Table 1 has the composition raw materials of effect of weight reducing
2, processing method
Raw material adds weight 10 times of water gagings, soaks 1 hour, and 98 DEG C ~ 100 DEG C decoct 2 hours, filter, and collects the another device storage of filtrate; The dregs of a decoction add 8 times of water gagings, and 98 DEG C ~ 100 DEG C decoct 1 hour, filter, merge twice filtrate, obtain soup.
Embodiment two
The present invention has the method for preparing tablet thereof of the composition of effect of weight reducing.
Embodiment one gained soup is condensed into thick paste, spraying dry, adds starch, wet granulation, dry, whole grain, compressing tablet, and dressing, every sheet weighs 0.6 ~ 1.0g, to obtain final product.
Embodiment three
The present invention has the capsule preparation method thereof of the composition of effect of weight reducing.
Embodiment one gained soup is condensed into thick paste, spraying dry, adds starch, and dry, pulverizing, sieve, filled capsules, every fills 0.4 ~ 0.6g, to obtain final product.
Embodiment four
The present invention has the oral liquor of the composition of effect of weight reducing.
Embodiment one gained soup is concentrated into 1:10(and raw material weight ratio) obtain concentrate; Concentrate adds proper honey, white granulated sugar, citric acid, potassium sorbate, purified water, filter, filling, hot pressing steam sterilizing, packaging, to obtain final product.
Test example one
Safety and toxicology is tested.
Test specimen: embodiment one obtains soup and is condensed into thick paste, adds 1% ~ 3% starch in right amount, is drying to obtain.
The test specimen aqueous solution: above-mentioned test specimen adds deionized water and configures and get final product.
Using the test specimen of the present composition as test specimen, carry out acute oral toxicity test, genetic toxicity test, rat 30 days feeding trials respectively.
1, acute oral toxicity test:
Get mouse 80, fasting 16h before test, is divided into 4 groups at random by body weight, often organizes 20, male and female half and half, is present composition administration group (be divided into example one composite formula the 1st group, the 2nd group, the 3rd group) and blank group.Gavage gives present composition solution and distilled water respectively, and administration group and blank group all give by 0.4ml/10g body weight gavage, observed and recorded reaction of animals symptom after administration, Continuous Observation 14d, and records body weight or possible death condition.
After result administration, rare just, the perpendicular symptom such as hair, lassitude of mouse appearance.When administration 7d weighs, administration group male mice and blank group male mice weight ratio comparatively have highly significant difference (p=0.01), mouse after administration 14d, the change without exception of general symptom, and body weight increases normal, compares without significant difference with control group.
Conclusion: it is 42g/kg that present composition gavage gives the maximum dosage of mouse, be equivalent to people with 700 times of clinical daily dose, without 1 dead mouse in the 14d observation period, mouse outward appearance change without exception after administration, feed, drinking-water, body weight growth and activity are all normal.
2, genetic toxicity test
2.1Ames test
Adopting through identifying satisfactory TA97, TA98, TA100 and TA102 bacterial strain, carrying out adding and testing (S9mix consumption is 0.5ml/ plate) with the dressing plate incorporation methods not adding rats'liver S9.If the test specimen of the present composition 5 dosage: 8 μ g/ plates, 40 μ g/ plates, 200 μ g/ plates, 1000 μ g/ plates, 5000 μ g/ plates (accurately take the test specimen 1.0g of the present composition in vial, adding distil water 20ml, most high workload concentration 50mg/ml is after abundant mixing, all the other concentration distilled water 5 doubly down dilute acquisition, the most high workload concentration 100 μ l of configuration adds flat board and is the highest final concentration 5000 μ g/ plate, and all the other concentration application of sample amounts are 100 μ l.Solution after all preparations adopts 8 pounds of 15min high pressure modes to carry out sterilizing), establish spontaneous contrast, solvent control (sterile purified water 100 μ l/ plate) and positive control simultaneously.The positive control not adding S9 test is 2,4, the 7-trinitro-s-9-Fluorenone (TA97, TA98) of 0.2 μ g/ plate, the sodium azide (TA100) of 1.5 μ g/ plates, the mitomycin C (TA102) of 0.5 μ g/ plate; The positive control adding S9 test is the 2-aminofluorene (TA97, TA98, TA100) of 10 μ g/ plates and 1, the 8-dihydroxy anthraquinone (TA102) of 50 μ g/ plates.Each test dose makes three parallel-plates, and repeating test once.
Result: no matter add and the test not adding S9, every plate of spontaneous control group on average returns and becomes clump count all in range of normal value, and every plate that positive controls is brought out on average returns and becomes clump count and be spontaneous control group more than two times, in obvious positive reaction.Average the returning of test specimen each dosage group of the present composition becomes one times that clump count does not all exceed spontaneous control group, and be negative reaction, and namely the test specimen of the present composition is without the effect of induction experiment bacterial strain back mutation.
2.2 mice bone marrow micronucleus
Kunming mouse (body weight 25g ~ 30g) is divided into 5 groups at random, often organize 10, male and female half and half, if 2.5,5.0 and the test specimen test group of 10.0g/kg.bw Tibetan medicinal composition of the present invention, separately establish negative control group (distilled water), positive control (endoxan 40mg/kg.bw) group.Animal presses 0.2ml/10gbw per os gavage respectively at 0h and 24h, and after last contamination, 6h puts to death animal, follow procedure film-making.Every animal counts 1000 polychromatic erythrocytes (PCE), observes containing the polychromatic erythrocyte number of micronucleus, calculates micronuclear rates (‰), to observe in 200 red blood cells PCE simultaneously and is just incarnadining number shared by cell (NCE), and calculating PCE/NCE ratio.
Result: positive controls is female, the micronuclear rates of tom is all significantly higher than control group (P<0.05), difference (P>0.05) that the micronuclear rates that the test specimen of the present composition is respectively organized compares with negative control group that there are no significant, prompting, the test specimen of the present composition is negative findings in mouse marrow cell micro nuclear test.
2.3 mouse inbred strain
Male Kunming strain mice (body weight 25g ~ 35g) is divided into 5 groups at random, often organizes 5.Test packet design with 2.2, every day per os gastric infusion once, continuous 5d.Put to death animal with 35d after gavage first, get bilateral epididymal, by regulation film-making, every animal observes 1000 complete sperms, records all kinds of defective sperm number.
Result: positive controls rate of teratosperm is all significantly higher than control group (P<0.05), difference (P>0.05) that the rate of teratosperm that the test specimen of the present composition is respectively organized compares with negative control group that there are no significant, prompting, the test specimen of the present composition is negative findings in mouse inbred strain.
Three genetic toxicity test results such as Salmonella reversion test, mice bone marrow micronucleus and mouse inbred strain are feminine gender, show that the test specimen of the present composition is without mutagenesis.
3, rat 30 days feeding trials
To wean rat 200 with body weight 60g ~ 80g, 10 groups are divided at random by body weight, be respectively test specimen (be respectively example one and fill a prescription the 1st group, the 2nd group, the 3rd group) the basic, normal, high dosage group of Normal group, the present composition, often organize 20, male and female half and half.Control group feed raise arm's length basis powder, the other per os gavage of basic, normal, high dosage component is doped with 6.67,33.33,66.67 times that the present composition 0.4g/kgbw, 2.0g/kgbw, 4.0g/kgbw(are equivalent to human body recommended intake respectively) feed.Single cage is fed, free diet, record rats eating amount, body weight, Continuous Observation 30d.Mix in feed to feed with the present composition of 0.4g/kgbw, 2.0g/kgbw, 4.0g/kgbw and raise rat 30d.
At duration of test, each treated animal grows well, and there are no significant (P>0.05) for the indices such as each dosage treated animal body weight, food utilization, organ coefficient and control group comparing difference.Except male 1.0%, 10.0%, the albumin of female 5.0% dosage group and control group comparing difference have conspicuousness except (P<0.05), routine blood test and other every biochemical indicators (transaminase, urea nitrogen, creatinine, cholesterol, triglyceride, blood sugar, total protein) are all in normal range (NR).Pathologic group checks that the tested internal organs of control group and each dosage group are showed no significant pathological change.
Test example two
Function assessment is tested: on the impact of high obese model rat.
Principle: T-CHOL (TC) in rat model serum and liver organization, triglycerides (TG) can be reduced after taking in composition of medicine of the present invention, thus reach the object of fat-reducing.
Animal used as test: clean level Wistar kind rat, 88, male, body weight 150g ~ 170g, single cage is raised.Thered is provided by Chinese Academy of Medical Sciences's Experimental Animal Center, the animal quality certification number: No. SCXKll-00-0006.The Animal House quality certification number: SYXK (capital) 2002-1022.
High lipid food is filled a prescription: 78.8% basal feed, 1% cholesterol, 10% yolk powder, 10% lard, 0.2% cholate.
Experimental technique: with healthy adult male rat 88, gets tail blood and surveys serum total cholesterol (TC), triglycerides (TG) and HDL (HDL-C) (main detecting instrument: HITACHl7170A automatic clinical chemistry analyzer).Be divided into 11 groups at random: basic, normal, high three dosage groups of negative control group, high-fat adiposity control group and administration group (being divided into example one to fill a prescription the 1st group, the 2nd group, the 3rd group), dosage is respectively 0.06g/kgBW, 0.30g/kgBW, 1.80g/kgBW, be equivalent to 1 times of human body recommended amounts, 5 times, 30 times, often organize 8 animals.Except negative control group to except normal diet other each group all give high lipid food feed.Tested material each dosage group gavage gives the tested material of various dose, and two control group gavages give the deionized water of same volume, all give tested material 30d by 1ml/100gBW gavage.Once a day, weigh weekly once.High-fat adiposity control group then gives the deionized water of same volume.Fasting 16h before off-test, after weighing, broken end is got blood and is surveyed serum total cholesterol (TC), triglycerides (TG) and HDL-C (HDL-C), cut open the belly simultaneously and get body fat (testis and perinephric fat pad) and weigh, and calculate body fat/end-body anharmonic ratio.
All test datas all adopt SPSS8.0 software to carry out statistical analysis.
Experimental result:
Table 2 present composition is on the impact of rat body weight
Note: compared with negative control group: high fat control group P<0.01.Compared with high fat control group: high dose group P<0.01.
Result listed by table 2, test last high-fat adiposity control animals weight gain higher than negative control group, and difference has highly significant (P<0.01).Feed simultaneously raise high lipid food middle and high dosage treated animal weight gain lower than high-fat adiposity control group, tool highly significant sex differernce (P<0.01).
Table 3 present composition is on the impact of rat fat index
Result listed by table 3, after test, high-fat adiposity control animals serum total cholesterol (TC), triglycerides (TG), serum High Density Lipoprotein Cholesterol (HDL-C) are higher than negative control group, and difference has highly significant (P<0.01).High fat animal model manufacture success is described, and the serum total cholesterol (TC) of each dosage treated animal and each dosage group triglycerides (TG) are all lower than high-fat adiposity control group, and difference has conspicuousness (P<0.05) or highly significant (P<0.01).Each dosage treated animal serum High Density Lipoprotein Cholesterol (HDL-C) is compared with high fat control group, there was no significant difference (P>0.05).
Table 4 present composition is on the impact of Serum Lipids in Experimental HypercholesterolemicRats
Note: this table institute column data is the fall of each dosage group TC or TG compared with high-fat adiposity control group.
Table 4 result is visible, and each dosage group serum total cholesterol (TC) and triglycerides (TG) all lower than high fat control group, and have and decline in various degree.The present composition has effect for reducing blood fat to rat.
Table 5 present composition is on the impact of rat physical index
Result listed by table 5, body fat weight in wet base and the body fat of testing last high-fat adiposity control animals compare all higher than negative control group, and through statistical test, the two body fat weight in wet base difference has conspicuousness, and animal obesity models manufacture success is described.And feed simultaneously and raise each dosage treated animal body fat weight in wet base of high fat nutrient fodder and body fat than all lower than high-fat adiposity control group, through statistical test, the body fat weight in wet base of middle and high dosage group and body fat have conspicuousness and highly aobvious (P<0.05 or P<0.01) than with high-fat adiposity control group comparing difference.
Conclusion: zoopery shows that the present composition has reducing weight and blood fat effect to rat.
Test example three
To Simple Obesity Patient clinical observation on the therapeutic effect.
1, inclusive criteria
(1) diagnosis basis: " diagnosis of simple obesity and efficacy assessment standard " and the ILSI " Chinese problem of obesity working group " that 1. announce according to obesity research association 1998 of health care science and technology association of China are on the basis of the horizontal analysis of 240,000 people's data and the prospective analysis of people more than 70,000, in calendar year 2001 propose " suggestion of Chinese Adult body mass index classification is thought: the easy and the most frequently used index that at present assessment is fat is square (m of body mass index (BMI), BMI=body weight (kg)/height
2).Chinese BMl is optimum range 18.5 ~ 23.9, and 24.0 ~ 27.9 is overweight, and more than 28.0 is fat.2. appearance is obviously fat, and subcutaneous fat thickens, and surveys the skinfold at triceps place, exceed the upper limit of normal skinfold with slide calliper rule.3. normally, height is normal for top and the bottom amount and span.
(2) exclusion standard: except the Secondary Obesity person that causes of endocrine metabolism disease, health check-up has severe cardiac, brain, liver, kidney diaseases .BMI<24.0 person.
2, physical data
Meet case 90 example of inclusive criteria, man 32 example, female 58 example; Minimum 14 years old of age, maximum 55 years old, average 43.6l year; Body weight 61.5kg ~ 108.0kg, average 78.9kg before treatment; BMI24.0 ~ 27.9kg/m
269 examples, 28.0kg/m
2be more than 21 examples, average 28.81kg/m
2; Merge fatty liver 18 example, 36 Cases of Hyperlipidemia, high blood pressure 6 example, coronary heart disease 9 example, without complication 21 example.
3, treatment and observational technique
Take the present composition (being divided into example one to fill a prescription the 1st group, the 2nd group, the 3rd group), be divided into 3 groups, often organize 30 people, take each 3 of the present composition respectively, every day 2 times, 0.6g/ sheet, within 3 months, be 1 course for the treatment of, medicine can be stopped 1 week at interval of 1 month.Period in a medicine, avoids high fat, high sugar and high salt diet, original dietary basis requires eat 1 egg every day, 1 bottle of milk; Breakfast is had enough, and lunch 8 one-tenth is satisfied, and hungry person is separately with vegetarian diet or fruit; Motion is basic keep taking medicine before state, monthly survey body weight, waistline, blood fat 1 time.
Test item: survey body weight, waistline, hip circumference, related biochemical indicator.
Instrument and reagent: Bodystatl500 type body composition analysis instrument (survey body weight), BT-224 semi-automatic biochemical analyzer.Triglycerides is tested, and T-CHOL kit, enzyme process HDL-C kit are Shanghai Long March medical science Co., Ltd product.Blood sugar detection, adopts Glucose oxidase paper test.Insulin Sensitivity Index, adopts the method that Guangwei LI etc. is introduced.
4, observation of curative effect
4.1 criterions of therapeutical effect: treat religion standard with reference to " new Chinese medicine guideline of clinical investigations " regarding obesity disease, Body weight loss > 3kg, serum total cholesterol on average reduces 1.25mmol/L, triglycerides on average reduces 0.67mmol/L, it is effective that ISI improves 20% ~ 49%, waistline decreased average 5.6cm." diagnosis of simple obesity and efficacy assessment standard " BMI decline >=2.0 that obesity research association of Chinese health care science and technology association announces for 1998 is effective.
4.2 observed results: after taking 1 course for the treatment of of the present composition continuously, compare before and after tested crowd tests, efficient 72.2% (95%CI=62.9% ~ 81.5%); Body weight loss and waistline, hip circumference reduces conspicuousness (P<0.05), and BMI decline difference has conspicuousness (P<0.05).The results are shown in Table 6.
Before and after table 6 treatment, body weight, waistline, hip circumference, BMI parameter compare
Conclusion: tested period experimenter is all without going on a diet and bad reaction.
Visible, the present composition can reduce the body weight of Simple Obesity effectively, waistline, hip circumference and BMI index, and the present composition is evident in efficacy to treatment simple obesity, and the MBI of 14.92% experimenter can be made to drop to optimum range.
Claims (15)
1. there is a composition for effect of weight reducing, it is characterized in that: raw material consists of kelp 30 parts, 20 parts, bent letter, rhizoma zingiberis 15 parts, sea-buckthorn 15 parts, myrobalan 10 parts.
2. composition according to claim 1 is preparing the application in health food.
3. application according to claim 2, is characterized in that: described health food is the health food possessing fat-reducing, fat reducing, body shaping effect.
4. composition according to claim 1 is preparing the application in medicine.
5. application according to claim 4, is characterized in that: described medicine is the medicine possessing fat-reducing, fat reducing, body shaping effect.
6. the health food containing composition according to claim 1.
7. health food according to claim 6, is characterized in that: be oral class.
8. prepare the method for health food according to claim 6, it is characterized in that: each raw material components is prepared in proportion, traditionally patent medicine processing method, add acceptable auxiliary material in pharmacy and be prepared into different dosage form.
9. method according to claim 8, is characterized in that: be one of following method:
Method one: choose raw material and prepare to scale, adds weight 10 times of water gagings, soaks 1h, and 98 DEG C ~ 100 DEG C decoct 2h, filter, and collects the another device storage of filtrate; The dregs of a decoction add 8 times of water gagings, and 98 DEG C ~ 100 DEG C decoct 1h, filter, merge twice filtrate, obtain soup;
Method two: choose raw material and prepare to scale, adds weight 10 times of water gagings, soaks 1h, and 98 DEG C ~ 100 DEG C decoct 2h, filter, and collects the another device storage of filtrate; The dregs of a decoction add 8 times of water gagings, and 98 DEG C ~ 100 DEG C decoct 1h, and filter, merge twice filtrate, obtain soup, gained soup, spraying dry, adds starch, wet granulation, dry, whole grain, compressing tablet, and dressing, obtains tablet;
Method three: choose raw material and prepare to scale, adds weight 10 times of water gagings, soaks 1h, and 98 DEG C ~ 100 DEG C decoct 2h, filter, and collects the another device storage of filtrate; The dregs of a decoction add 8 times of water gagings, and 98 DEG C ~ 100 DEG C decoct 1h, and filter, merge twice filtrate, obtain soup, gained soup, adds starch, and dry, pulverizing, sieves, filled capsules;
Method four: choose raw material and prepare to scale, adds weight 10 times of water gagings, soaks 1h, and 98 DEG C ~ 100 DEG C decoct 2h, filter, and collects the another device storage of filtrate; The dregs of a decoction add 8 times of water gagings, and 98 DEG C ~ 100 DEG C decoct 1h, filter, merge twice filtrate, soup, gained soup, to be concentrated into raw material weight than 1:10, to obtain concentrate, concentrate seasoning, adds purified water, filter, filling, hot pressing steam sterilizing, packaging, obtain oral liquid.
10. method according to claim 9, is characterized in that: in described method four, concentrate adds proper honey, white granulated sugar, citric acid, potassium sorbate, purified water, filter, filling, hot pressing steam sterilizing, packaging, obtain oral liquid.
11. containing the medicine of composition according to claim 1.
12. medicines according to claim 11, is characterized in that: be oral class.
The method of 13. preparation medicine according to claim 11, is characterized in that: prepared in proportion by each raw material components, traditionally patent medicine processing method, adds acceptable auxiliary material in pharmacy and be prepared into different dosage form.
14. methods according to claim 13, is characterized in that: be one of following method:
Method one: choose raw material and prepare to scale, adds weight 10 times of water gagings, soaks 1h, and 98 DEG C ~ 100 DEG C decoct 2h, filter, and collects the another device storage of filtrate; The dregs of a decoction add 8 times of water gagings, and 98 DEG C ~ 100 DEG C decoct 1h, filter, merge twice filtrate, obtain soup;
Method two: choose raw material and prepare to scale, adds weight 10 times of water gagings, soaks 1h, and 98 DEG C ~ 100 DEG C decoct 2h, filter, and collects the another device storage of filtrate; The dregs of a decoction add 8 times of water gagings, and 98 DEG C ~ 100 DEG C decoct 1h, and filter, merge twice filtrate, obtain soup, gained soup, spraying dry, adds starch, wet granulation, dry, whole grain, compressing tablet, and dressing, obtains tablet;
Method three: choose raw material and prepare to scale, adds weight 10 times of water gagings, soaks 1h, and 98 DEG C ~ 100 DEG C decoct 2h, filter, and collects the another device storage of filtrate; The dregs of a decoction add 8 times of water gagings, and 98 DEG C ~ 100 DEG C decoct 1h, and filter, merge twice filtrate, obtain soup, gained soup, adds starch, and dry, pulverizing, sieves, filled capsules;
Method four: choose raw material and prepare to scale, adds weight 10 times of water gagings, soaks 1h, and 98 DEG C ~ 100 DEG C decoct 2h, filter, and collects the another device storage of filtrate; The dregs of a decoction add 8 times of water gagings, and 98 DEG C ~ 100 DEG C decoct 1h, filter, merge twice filtrate, soup, gained soup, to be concentrated into raw material weight than 1:10, to obtain concentrate, concentrate seasoning, adds purified water, filter, filling, hot pressing steam sterilizing, packaging, obtain oral liquid.
15. methods according to claim 14, is characterized in that: in described method four, concentrate adds proper honey, white granulated sugar, citric acid, potassium sorbate, purified water, filter, filling, hot pressing steam sterilizing, packaging, obtain oral liquid.
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Citations (4)
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JPS6062944A (en) * | 1983-09-16 | 1985-04-11 | Teruaki Shimazu | Nutrient reducing tea |
CN1506090A (en) * | 2002-12-06 | 2004-06-23 | 李玉峰 | Rheum emodi wall extract and medicine composition with the extract as active component |
CN1709447A (en) * | 2005-07-06 | 2005-12-21 | 甘肃奇正藏药有限公司 | Tibetan medicine formulation for treating hyperlipemia, and its preparing method |
CN101015603A (en) * | 2007-02-01 | 2007-08-15 | 甘肃奇正藏药有限公司 | Medicine composition with fat-reducing and bowel relaxing functions, preparing process and quality controlling means thereof |
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS6062944A (en) * | 1983-09-16 | 1985-04-11 | Teruaki Shimazu | Nutrient reducing tea |
CN1506090A (en) * | 2002-12-06 | 2004-06-23 | 李玉峰 | Rheum emodi wall extract and medicine composition with the extract as active component |
CN1709447A (en) * | 2005-07-06 | 2005-12-21 | 甘肃奇正藏药有限公司 | Tibetan medicine formulation for treating hyperlipemia, and its preparing method |
CN101015603A (en) * | 2007-02-01 | 2007-08-15 | 甘肃奇正藏药有限公司 | Medicine composition with fat-reducing and bowel relaxing functions, preparing process and quality controlling means thereof |
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