CN101884739B - Food therapy preparation for preventing and treating diabetes based on theories of preventive treatment of disease and medicine food homology - Google Patents
Food therapy preparation for preventing and treating diabetes based on theories of preventive treatment of disease and medicine food homology Download PDFInfo
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- CN101884739B CN101884739B CN2009100688650A CN200910068865A CN101884739B CN 101884739 B CN101884739 B CN 101884739B CN 2009100688650 A CN2009100688650 A CN 2009100688650A CN 200910068865 A CN200910068865 A CN 200910068865A CN 101884739 B CN101884739 B CN 101884739B
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Abstract
The invention relates to a food therapy preparation for preventing and treating diabetes based on the theories of preventive treatment of disease and medicine food homology, which is characterized by comprising the effective ingredients of the following raw materials in weight ratio: 4-6 dark plum fruits, 6-8 fragrant solomonseal rhizome, 14-16 Chinese yam, 4-6 barbary wolfberry fruits, 6-8 hawthorn and 14-16 fresh reed roots. The prescription of the food therapy preparation is based on the theory of preventive treatment of disease, and the food therapy preparation is prepared from a sufficient amount of effective ingredients. Although the food therapy preparation is not a medicine, the actions of the medicine can be exerted. The food therapy preparation not only can greatly limit the occurrence and the development of the diabetes, but also can save a great amount of medical resources and investments for China simultaneously. People can conveniently and correctly select the food therapy preparation in a pertinence way according to early symptoms per se to prevent the possible occurrence of the diabetes, and thus, the purposes of disease prevention and body building are achieved. The food therapy preparation can be directly taken according to a certain amount, and can also be eaten together with foods and drinks as an additive of the foods and the drinks.
Description
Technical field
The invention belongs to food therapy preparation, particularly relate to a kind of based on preventive treatment of disease and the theoretical food therapy preparation of preventing and treating diabetes of integration of edible and medicinal herbs.
Background technology
Come from Chinese medicine " preventive treatment of disease " thought of Huangdi's Internal Classics; Receive elucidating of Han dynasty Zhang Zhongjing " Treatise on Febrile and Miscellaneous Disease " and " Medical Treasures of the Golden Chamber "; After ancient Chinese medicine doctor is enriched constantly and is developed; Begun to take shape comparatively complete theory and practice system clearly to bright, may be summarized to be with health is core, comprises (1) anosis health preserving, takes preventive measures; (2) the desire disease is rescued and is sprouted, checks erroneous ideas at the outset; (3) control, prevent its change of disease sick morning; (4) take good care of oneself, prevent to recur the substance of four aspects after being ill.The sub-health state that people often mention both belonged to the scope of " preventive treatment of disease " " anosis health preserving, take preventive measures ".Chinese medicine for the common measure of " preventive treatment of disease " take good care of oneself that feelings will, dietetic therapy rationally, daily life often have, strike a proper balance between work and rest, Traditional health care, acupuncture and tuina-massage and herbal treatment.
" integration of edible and medicinal herbs " be the Chinese nation over 10000000 year with the experience crystallization of the Nature and disease long-term struggle, the dietetic therapy that grows up thus also has distinct characteristic, is one of the common measure of " preventive treatment of disease ".China's Ministry of Public Health in 2002 announced be food be again the article list of medicine, totally 87 kinds of article.
In the prior art; To prevent and treat diabetes and use be food be that the prescription of medicine article is more common in and some Chinese medicine mixed configuration; For example application number is 200510046692.4 patent of invention manner " health food of blood sugar lowering, blood fat reducing and method for making thereof ", is made up of the component of following weight part ratio: Rhizoma amorphophalli 85-115, Fructus Momordicae charantiae 68-92, Fructus Lycii 51-69, Radix Astragali 34-46, Radix Ginseng 17-23.Application number is 02136450.8 patent of invention manner " a kind of natural health care " for another example, is made by weight ratio by following each composition: brown rice 13.5-15.5 part, Semen Sesami Nigrum oil 22-24 part, green tea 25-27 part; Fructus Citri grandis 1-1.5 part, Tricholoma matsutake (lto et lmai) Singer 0.1-0.2 part, bamboo grove bacterium 1-2 part; Semen Canavaliae 1-2 part, Agaricus blazei 3-4 part, Antler Mythic Fungus 2-3 part; Radix Ginseng 1.5-2 part, Pericarpium Citri Reticulatae 0.5-1 part, black fermented preparation daughter bacteria 0.1-0.3 part; Rice vinegar 1-1.5 part, gelatin 24-26 part, more remarkable to the adjuvant treatment effect of diabetes.
In the actual life; People for prevent and treat diabetes Dietotherapy method have certain cognition and application level, still, people generally reflect reality not remarkable to preventing and treating the food therapy effect of diabetes in the life; Investigate according to the applicant; Its reason has three, one, because bioactive ingredients content is lower in the integration of edible and medicinal herbs article, is not enough to manifest the prevention effect to diabetes; The 2nd, eating method is improper, causes the loss of active component; The 3rd, can not strictness follow Chinese medicine and pharmacy determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs principle and select " food " because of the people suits the medicine to the illness.
Summary of the invention
The objective of the invention is in order to solve in the actual life for the food therapy effect of preventing and treating diabetes and inapparent technical problem; And a kind of food therapy preparation of preventing and treating diabetes based on preventive treatment of disease and integration of edible and medicinal herbs theory is disclosed, said preparation has the outstanding feature that Chinese medicine and pharmacy determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs principle is followed in strictness.
The food therapy preparation of preventing and treating diabetes of the present invention is made up of the effective ingredient of following weight ratio raw material components: Fructus Mume 4-6, Rhizoma Polygonati Odorati 6-8, Rhizoma Dioscoreae 14-16, Fructus Lycii 4-6, Fructus Crataegi 6-8, fresh Rhizoma Phragmitis 14-16.
The weight ratio of said each dietetic therapy raw material components is Fructus Mume 5, Rhizoma Polygonati Odorati 7, Rhizoma Dioscoreae 15, Fructus Lycii 5, Fructus Crataegi 7, fresh Rhizoma Phragmitis 15.
Said food therapy preparation is powder, granule, capsule or tablet.
The basic effective constituents of above-mentioned each dietetic therapy raw material components and main effect thereof are:
Fructus Mume: containing main effective ingredient is citric acid, has the effect of Yin-nourishing and body fluid promoting.
Rhizoma Polygonati Odorati: contain polysaccharide, saponin, alcohol have the effect of Yin-nourishing and body fluid promoting.
Rhizoma Dioscoreae: contain dioscin and glycoside thereof unit diosgenin, also contain only wooden fork plain, 3,4-dihydroxy benzenes ethamine, mannan, allantoin, Rhizoma Dioscoreae element etc. have the effect of spleen reinforcing nourishing the stomach.
Fructus Crataegi: contain citric acid, have the effect of blood circulation promoting and blood stasis dispelling.
Fructus Lycii: contain amygdalin, polysaccharide, have the effect of blood circulation promoting and blood stasis dispelling.
Fresh Rhizoma Phragmitis: contain ferulic acid, have the effect of clearing away heat and promoting production of body fluid.
Diabetes are higher at the sickness rate of China, and the serious threat people's is healthy.Belong to that motherland's medical science " is quenched one's thirst " or the category of " diseases due to endogenous heat of ZANG FU organs ".Its main pathogenesis is a consumption of YIN-fluid, water paddy transfer not normal due to, so with YIN nourishing spleen invigorating ruling by law.The applicant according to the evidence-based medicine EBM theory induction early symptom of nephropathy: 1 painless myocardial infarction.2 sexual impotence.3 precipitate visual deteriorations.4 cataract that develop rapidly.5 postprandial hypoglycemias.6 acroanesthesias.7 scapulohumeral pains pain, stiff.8 stubbornnesses or intermittent diarrhea.9 touching infection of not healing.10 skin blisters.11 agnogenic edema.12 eat many, drink many, urine many, lose weight.Especially the people who meets following situation more should prevent the generation of nephropathy: 1 has the diabetes family history, and the age is person more than 40 years old; 2 overweight peoples, especially age be the overweight people more than 40 years old, and occur the weight loss person of unknown cause in the recent period; 3 suffer from the infected of cureless female vulva Pruritus or urinary system; 4 women have postterm pregnancy, fetus is excessive or stillborn fetus medical history person.The 5 glucose in urine positives and the normal person of fasting glucose.
This food therapy preparation is according to the early symptom of diabetes, and with Fructus Mume, Rhizoma Polygonati Odorati Yin-nourishing and body fluid promoting, Rhizoma Dioscoreae spleen reinforcing nourishing the stomach is a monarch drug to help fortuneization altogether; The Fructus Lycii nourishing the liver and kidney; The Fructus Crataegi blood circulation promoting and blood stasis dispelling is thought minister, makes with the fresh Rhizoma Phragmitis clearing away heat and promoting production of body fluid, and full side share and plays the YIN nourishing spleen invigorating altogether, the merit of the heat clearing away of invigorating blood circulation.
This food therapy preparation is according to the theoretical prescription of " preventive treatment of disease "; And form with the effective ingredient of q.s; Though be not the effect that medicine but can play medicine, in the incidence and development that reduces diabetes greatly, can also save a large amount of medical resources and investment for country.
This food therapy preparation is convenient to people and is possibly caused diabetes to take place according to self early symptom and accurately select, sit in the right seat, and reaches the purpose of anti-treating diseases and making health-care.
This food therapy preparation can directly be taken according to quantity.
Its beneficial effect of food therapy preparation of the present invention can access proof through following test.
Test name: this food therapy preparation is to the blood sugar reducing function of diabetic mice due to the alloxan.
1 test material:
The ICR mice, body weight 22 ± 2 grams, male and female half and half.By this food therapy preparation that Rhizoma Dioscoreae, Fructus Mume, Rhizoma Polygonati Odorati, Fructus Crataegi, Fructus Lycii, fresh Rhizoma Phragmitis effective ingredient are formed, paste-forming rate is 5.07%.Receive reagent liquid concentration 2.25g/ml.Alloxan, Sigma company.
2 methods and result:
2.1 the foundation of diabetic mice model
ICR mice elder generation adaptability was fed after 3 days, and fasting 12 hours is freely drunk water, and every mice makes the diabetic mice model by the disposable injection alloxan in 200mg/kg abdominal cavity.Fasting glucose was surveyed on the 4th day in the injection back, and fasting blood sugar is included diabetes model in greater than 10.00mmol/L person.
2.2 animal divides into groups and handles
Diabetic mice is divided into model group, drug group (18mg/kg) at random, establishes a normal group in addition, 10 every group simultaneously.Administration group gastric infusion every day once, model group and normal group are irritated the stomach normal saline once every day, irritate stomach volume 20ml/kg, continuous 4 weeks.4 weekends each is organized mice fasting 12 hours, the eye socket venous plexus is got blood, measures blood glucose with blood glucose meter.
2.3 result
The result is by shown in the table 1, and drug group is to the influence of blood glucose in diabetic mice due to the alloxan, and model group mouse blood sugar value is significantly higher than normal group; Diabetic mice gives the blood glucose of medicinal liquid treatment back mice and compares with model group, significantly reduces.Explain that medicine can reduce blood glucose in diabetic mice.
The influence of blood glucose in diabetic mice due to the table 1 pair alloxan
Annotate: with model group significant difference * P＜0.05 is arranged relatively, extremely significant difference ##P＜0.01 is relatively arranged with blank control group
3 conclusions: test the result and show, receive reagent liquid can reduce the blood glucose value of diabetic mice due to the alloxan, can be used for the prevention of diabetics.
The acute toxicity testing of this food therapy preparation:
1 experiment material
1.1 laboratory animal ICR mice SPF level, available from Institute of Radiation Medicine, Chinese Academy of Medical Sciences's Experimental Animal Center, credit number: SCXK Tianjin 2005-0001.Totally 40, male and female half and half, body weight 20 ± 1 grams.
1.2 this food therapy preparation that medicine is made up of Rhizoma Dioscoreae, Fructus Mume, Rhizoma Polygonati Odorati, Fructus Crataegi, Fructus Lycii, fresh Rhizoma Phragmitis effective ingredient; It is 0.24g/ml that adjusting receives reagent liquid concentration; Make it can pass through the mouse stomach device, do not receive to try concentration most greatly but do not produce to stop up to it, existing with join at present.
This food therapy preparation paste-forming rate is 5.07%, and the clinical application amount is 0.90g/kg.
1.3 experimental condition: 20 ℃-25 ℃ of room temperatures, relative humidity 45-60%RH, exhaust fan ventilates, and the air-conditioning attemperation was swept the Mus house one time in 3 days, kept clean, and light/dark time is 12/12 hour.
2 methods
Fasting can't help water 12 hours before the test, was divided into 2 groups according to the sex body weight, normal control group and administration group.The disposable filling stomach of administration group is given every 0.8ml of Cmax medicinal liquid, and matched group gives the co-content distilled water.Outward appearance, behavioral activity, ergasia, breathing, appetite, defecation and color thereof, the muzzle chamber of observing mice subsequently have or not abnormal secretion thing, body weight change and death condition.Dead animal in time performs an autopsy on sb, and the discovery diseased organ is done the pathology histological examination, observes continuously 7 days.
Observation index sees table 1 for details.
Table 1 animal acute toxicity test is observed table
Animal was observed 7 after the 3 experimental result administrations; Muscular movement atremia, tic, ataxia, paralysis as a result; Muscular tension reaction is normal, and neuro-vegetative response, breathing, skin color are normal, and diet is no abnormal; The mice activity freely, do not have cry unusual, tremble, convulsions, movement disorder, sialorrhea, shed tears, phenomenons such as rhinorrhea, dyspnea, diarrhoea, constipation, intestinal tympanites take place.Animal skin gloss compares weight increase before none death of animal in 7 days after the administration, animal and administration, compare the weight of animals there was no significant difference (seeing table 2 for details) with matched group, does not also have other abnormal phenomenas.Animal on the 8th all takes off cervical vertebra and puts to death; By only doing postmortem; Each internal organs of perusal rat, the equal no abnormality seens in organs and tissues position such as the heart, liver, spleen, lung, kidney, adrenal gland, thymus, stomach, intestinal, bladder, testis, prostate, uterus, ovary, thoracic cavity, abdominal cavity as a result.
The influence of table 2 pair mice body weight
This test maximum dosage-feeding is 40ml/kg * 0.24g/ml=9.60g/kg, is equivalent to crude drug in whole 9.60g/kg ÷ 0.0507g/g=189.35g/kg, is equivalent to 189.35g/kg ÷ 0.90g/kg=210 times of Coming-of-Age Day consumption 0.90g/kg.
Conclusion:
This test is irritated stomach and is given ICR mice, and the maximum possible dosage is 189.35g/kg, is equivalent to 210 times of 60kg Coming-of-Age Day consumption, and death does not appear in animal, does not have the acute toxicity effect so this food therapy preparation filling stomach gives mice.
The specific embodiment
Further specify the present invention below in conjunction with embodiment.
Embodiment 1
Get Fructus Mume 6 weight portions, Rhizoma Polygonati Odorati 8 weight portions, Rhizoma Dioscoreae 14 weight portions, Fructus Lycii 4 weight portions, Fructus Crataegi 6 weight portions, fresh Rhizoma Phragmitis 16 weight portions.
Above Six-element adds 10 times of water gagings and decocts 2 times, each 1 hour, filters; Collecting decoction is concentrated into 1g/ml, puts to room temperature, adds ethanol to containing alcohol amount 80%; Stir, left standstill 24 hours, supernatant is reclaimed ethanol to there not being the alcohol flavor; Concentrate, paste-forming rate is 5.07%, and promptly per 100 gram medical materials get extract 5.07 grams.
The spray-dried one-tenth powder of paste medicinal liquid, damp-prrof packing, weight depends on the needs.
The powder of embodiment 1 can add in beverage, the food edible, all can in the addition 1-5% scope.Also can process aqueous solution by above addition and spray in the Folium Camelliae sinensis surface, back to be dried comes into the market with Folium Camelliae sinensis by the tea packaging form.
Embodiment 2
Get Fructus Mume 5 weight portions, Rhizoma Polygonati Odorati 7 weight portions, Rhizoma Dioscoreae 15 weight portions, Fructus Lycii 5 weight portions, Fructus Crataegi 7 weight portions, fresh Rhizoma Phragmitis 15 weight portions.
Press the method effective component extracting of embodiment 1, paste-forming rate is 5.07%, becomes granule after the spray drying, bag distribution packaging, and every bag of 2g can be directly oral, becomes 1 bag of human oral one time, every day three times.
Embodiment 3
Get Fructus Mume 4 weight portions, Rhizoma Polygonati Odorati 6 weight portions, Rhizoma Dioscoreae 16 weight portions, Fructus Lycii 6, Fructus Crataegi 6 weight portions, fresh Rhizoma Phragmitis 14 weight portions.
Press the method effective component extracting of embodiment 1, paste-forming rate is 5.07%, and the powder after the spray drying adds an amount of excipient and becomes granule, and capsulation becomes capsule, and every capsules contains granule 340mg.Become 6 of human oral one time, every day three times.
Embodiment 4,
Get Fructus Mume 5 weight portions, Rhizoma Polygonati Odorati 7 weight portions, Rhizoma Dioscoreae 15 weight portions, Fructus Lycii 5 weight portions, Fructus Crataegi 7 weight portions, fresh Rhizoma Phragmitis 15 weight portions.
Press the method effective component extracting of embodiment 1, paste-forming rate 5.07%, powdered after the spray drying adds an amount of excipient compacting in flakes, and sugar coating promptly gets.
Every in the tablet of embodiment 4 contains effective composition 450mg, becomes 4 of human oral, every day three times, does not limit after ante cibum.
Claims (3)
1. the food therapy preparation of preventing and treating diabetes based on preventive treatment of disease and integration of edible and medicinal herbs theory is characterized in that being made up of the contained effective ingredient of the raw material of following weight ratio: Fructus Mume 4-6, Rhizoma Polygonati Odorati 6-8, Rhizoma Dioscoreae 14-16, Fructus Lycii 4-6, Fructus Crataegi 6-8, fresh Rhizoma Phragmitis 14-16.
2. the food therapy preparation of preventing and treating diabetes according to claim 1 is characterized in that being made up of the contained effective ingredient of the raw material of following weight ratio: Fructus Mume 5, Rhizoma Polygonati Odorati 7, Rhizoma Dioscoreae 15, Fructus Lycii 5, Fructus Crataegi 7, fresh Rhizoma Phragmitis 15.
3. the food therapy preparation of preventing and treating diabetes according to claim 1 is characterized in that: said food therapy preparation is powder, granule, capsule or tablet.
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| CN109394966A (en) * | 2018-11-08 | 2019-03-01 | 沈阳衡天然生物科技有限公司 | A kind of mulberry leaf compound and preparation method thereof |
| CN109223902A (en) * | 2018-11-15 | 2019-01-18 | 上海市松江区方松街道社区卫生服务中心 | It is a kind of for intervening the Chinese medicine composition of prediabetes crowd |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1113146A (en) * | 1994-03-08 | 1995-12-13 | 哈尔滨中药三厂 | Prescription of preparation for curing diabetes |
| CN101120998A (en) * | 2006-08-08 | 2008-02-13 | 芮育健 | New use of traditional Chinese medicines white peony root, Chinese yam, and rhizome polygonatum for diabetes syndrome-eliminating liver-kidney-nourishing and treating diabetes |
| CN101134083A (en) * | 2007-09-18 | 2008-03-05 | 王平 | Chinese medicinal herb capsule for treating diabetes and its complication and method for preparing the same |
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2009
- 2009-05-15 CN CN2009100688650A patent/CN101884739B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1113146A (en) * | 1994-03-08 | 1995-12-13 | 哈尔滨中药三厂 | Prescription of preparation for curing diabetes |
| CN101120998A (en) * | 2006-08-08 | 2008-02-13 | 芮育健 | New use of traditional Chinese medicines white peony root, Chinese yam, and rhizome polygonatum for diabetes syndrome-eliminating liver-kidney-nourishing and treating diabetes |
| CN101134083A (en) * | 2007-09-18 | 2008-03-05 | 王平 | Chinese medicinal herb capsule for treating diabetes and its complication and method for preparing the same |
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