CN108635460A - A kind of essential oil having antiobesity action - Google Patents

A kind of essential oil having antiobesity action Download PDF

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CN108635460A
CN108635460A CN201810915587.7A CN201810915587A CN108635460A CN 108635460 A CN108635460 A CN 108635460A CN 201810915587 A CN201810915587 A CN 201810915587A CN 108635460 A CN108635460 A CN 108635460A
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essential oil
oil
cymene
rheum officinale
peppermint
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苗明三
白莉
常冰洁
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Henan University of Traditional Chinese Medicine HUTCM
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Henan University of Traditional Chinese Medicine HUTCM
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/235—Foeniculum (fennel)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708—Rheum (rhubarb)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction

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Abstract

The purpose of the present invention is just to provide a kind of essential oil having antiobesity action, is by following volumes meter：8 12ml of P-Cymene, 13 17ml of datura flower essential oil, 4 6ml of semen brassicae essential oil, 8 12ml of rheum officinale essential oil, 8 12ml of Fructus Foeniculi quintessence oil, 8 12ml of Peppermint essential oil, 4 6ml of capsicum oil are uniformly mixed and are made；Compatibility of the present invention is scientific and reasonable, the effect of having and proceed blood cycle, eliminate fat accumulation, effective for weight-reducing, treats obesity, drug safety is convenient to take, good effect, and application easy to spread is the innovation on slimming medicine, there is good economic and social benefit.

Description

A kind of essential oil having antiobesity action
Technical field
The present invention relates to Chinese medicine, especially a kind of essential oil having antiobesity action.
Background technology
Obesity refers to that body fat accumulation is excessive and (or) abnormal distribution, the 20% of the weight that is above standard, and without apparent The inner-sphere reorganization energy cause of disease, obesity had not only influenced the health of people, but also influenced formal beauty, can be caused centainly to the phychology of people Harmful effect therefore caused the most attention of people to the treatment of obesity, though the existing a variety of medicines for having treatment obesity Object, but for various reasons, treat and unsatisfactory, some even generates side effect, and the purpose of weight-reducing is not only not achieved, also Complication is produced, therefore, how to solve the problems, such as that the medication of bariatrician is always that it is desirable to solve.
Invention content
For the above situation, to overcome the defect of the prior art, the purpose of the present invention, which is just to provide one kind, antiobesity action Essential oil, can effectively solve the problems, such as weight-reducing, treatment obesity.
The technical solution that the present invention solves is that a kind of essential oil having antiobesity action is by following volumes meter：P-Cymene 8-12ml, datura flower essential oil 13-17ml, semen brassicae essential oil 4-6ml, rheum officinale essential oil 8-12ml, Fructus Foeniculi quintessence oil 8-12ml, peppermint Essential oil 8-12ml, capsicum oil 4-6ml are uniformly mixed and are made；
The P-Cymene is that folium artemisiae argyi was ground into the coarse powder of 10~20 mesh sieve, supercritical CO2Fluid extraction, material Liquid w/v 1:10~20, w/v refers to solid in terms of g, and liquid is in terms of mL, 42~50 DEG C of extraction temperature, extraction 20~25MPa of pressure, 50~60 DEG C, 4.5~5.5MPa of separating pressure, 1.5~2.5h of extraction time of separation temperature obtain folium artemisiae argyi essence Oil；
It is prepared by the datura flower essential oil, semen brassicae essential oil, rheum officinale essential oil, Fructus Foeniculi quintessence oil, Peppermint essential oil, capsicum oil The same P-Cymene of method.
Compatibility of the present invention is scientific and reasonable, the effect of having and proceed blood cycle, eliminate fat accumulation, effective for weight-reducing, treatment Obesity, drug safety is convenient to take, good effect, and application easy to spread is the innovation on slimming medicine, there is good economy And social benefit.
Specific implementation mode
It elaborates with reference to embodiments to the specific implementation mode of the present invention with particular condition in use.
The present invention can be provided by following embodiment：
Embodiment 1：A kind of essential oil having antiobesity action of the present invention, is by following volumes meter：P-Cymene 10ml, ocean gold Flower essential oil 15ml, semen brassicae essential oil 5ml, rheum officinale essential oil 10ml, Fructus Foeniculi quintessence oil 10ml, Peppermint essential oil 10ml, capsicum oil 5ml It is uniformly mixed and is made；
The P-Cymene is that folium artemisiae argyi was ground into the coarse powder of 10~20 mesh sieve, supercritical CO2Fluid extraction, material Liquid w/v 1:10~20, w/v refers to solid in terms of g, and liquid is in terms of mL, 42~50 DEG C of extraction temperature, extraction 20~25MPa of pressure, 50~60 DEG C, 4.5~5.5MPa of separating pressure, 1.5~2.5h of extraction time of separation temperature obtain folium artemisiae argyi essence Oil；
It is prepared by the datura flower essential oil, semen brassicae essential oil, rheum officinale essential oil, Fructus Foeniculi quintessence oil, Peppermint essential oil, capsicum oil The same P-Cymene of method.
Embodiment 2：A kind of essential oil having antiobesity action of the present invention, is by following volumes meter：P-Cymene 8ml, ocean gold Flower essential oil 13ml, semen brassicae essential oil 4ml, rheum officinale essential oil 8ml, Fructus Foeniculi quintessence oil 8ml, Peppermint essential oil 8ml, capsicum oil 4ml are mixed Conjunction is uniformly made；
It is the P-Cymene, datura flower essential oil, semen brassicae essential oil, rheum officinale essential oil, Fructus Foeniculi quintessence oil, Peppermint essential oil, peppery The preparation method is the same as that of Example 1 for green pepper essential oil.
Embodiment 3：A kind of essential oil having antiobesity action of the present invention, is by following volumes meter：P-Cymene 12ml, ocean gold Flower essential oil 17ml, semen brassicae essential oil 6ml, rheum officinale essential oil 12ml, Fructus Foeniculi quintessence oil 12ml, Peppermint essential oil 12ml, capsicum oil 6ml It is uniformly mixed and is made；
It is the P-Cymene, datura flower essential oil, semen brassicae essential oil, rheum officinale essential oil, Fructus Foeniculi quintessence oil, Peppermint essential oil, peppery The preparation method is the same as that of Example 1 for green pepper essential oil.
Embodiment 4：A kind of essential oil having antiobesity action of the present invention, is by following volumes meter：P-Cymene 12ml, ocean gold Flower essential oil 13ml, semen brassicae essential oil 6ml, rheum officinale essential oil 8ml, Fructus Foeniculi quintessence oil 12ml, Peppermint essential oil 8ml, capsicum oil 6ml are mixed Conjunction is uniformly made；
It is the P-Cymene, datura flower essential oil, semen brassicae essential oil, rheum officinale essential oil, Fructus Foeniculi quintessence oil, Peppermint essential oil, peppery The preparation method is the same as that of Example 1 for green pepper essential oil.
Embodiment 5：A kind of essential oil having antiobesity action of the present invention, is by following volumes meter：P-Cymene 8ml, ocean gold Flower essential oil 17ml, semen brassicae essential oil 4ml, rheum officinale essential oil 12ml, Fructus Foeniculi quintessence oil 8ml, Peppermint essential oil 12ml, capsicum oil 4ml It is uniformly mixed and is made；
It is the P-Cymene, datura flower essential oil, semen brassicae essential oil, rheum officinale essential oil, Fructus Foeniculi quintessence oil, Peppermint essential oil, peppery The preparation method is the same as that of Example 1 for green pepper essential oil.
The present invention have weight-reducing the effect of, can be effectively used for treatment simple obesity, and through experiment achieve it is very good Advantageous effects, related testing data is as follows：
One, animal experiment
1. experiment material
1.1 reagent chemicals
Jiangzhi Jianfei Tablets, Harbin ocean pharmaceutical Co. Ltd, product batch number 160602；High lipid food formula (proportioning (g/ Kg) basal feed 788, lard 100, yolk powder 100, cholesterol 10, cholate 2)；Essential oil (body is gently formulated essential oil) of the present invention, by Henan university of TCM Drug Manufacturing Room provide；GSH-PX, TC, TG, HDL, LDL kit, the limited public affairs of Suzhou Calvin biotechnology Department.
1.2 laboratory apparatus
FA (N)/JA (N) a series of electronic balances, Shanghai Min Qiao precision instruments Co., Ltd；HWS12 type electric heating constant temperature water-baths Pot, Shanghai Yiheng Scientific Instruments Co., Ltd；KDC-160HR high speed freezing centrifuges, it is good in Keda Innovation Co., Ltd Branch company；680 type microplate reader, BIO-RAD companies of the U.S.；Adjustable pipette, Shanghai Lei Bo Analytical Instrument Co., Ltd；DHG- 9038A electric heating constant-temperature blowing drying boxes, the upper macro experimental facilities Co., Ltd of Nereid.
1.3 experimental animal
ICR mouse, grade：It is qualified to provide animal by Shandong Province's animal experimental center for SPF, male mouse 84, weight 18-22g Card number：37009200008096, rearing conditions：20-25 DEG C of temperature, humidity 40%-70%.
2. experimental method
By ICR male mices 50 (18-22g), after laboratory adaptability is raised 7 days, it is blank to separate 19 at random Group, remaining mouse is per 10, cage, after being raised 5 weeks with high lipid food.It weighs, modeling success mouse is divided into hyperlipidemia model by weight Group, positive drug group gavage Jiangzhi Jianfei Tablets suspension (), and the large and small dosage group of essential oil of the present invention is (with pushing away mao device by mouse web portion area The depilation of domain 1cm × 1cm areas, daily abdomen uniformly smears test medicine after depilation, small dose group administration 0.1ml, large dosage of group Administration 0.2ml (morning and afternoon respectively applies primary), every group 10.Blank group gives normal diet nursing, other 6 groups are given feeding high in fat Material, weighing mouse weight is primary weekly, continuously continues modeling, medication 20 days again.It is primary that mouse weight is weighed weekly, and according to body Recanalization dosage.Mouse weight is weighed again in last dose, and fasting 12h plucks eyeball and takes blood, takes mouse liver, thymus gland, claims Its liver of re-computation and thymus gland coefficient, and take part liver tissue homogenate.Thymus index=(thymic weight/weight) × 1000；Liver Dirty index=liver weight/weight；Lee ' s indexes=weight (g) ^ (1/3)/body length (cm).
Take liver 0.5g or so, 9 times of weight cold saline homogenate that remaining liver and thymus gland are put into formalin and done Pathological section is spare.Mouse blood and liver homogenate are centrifuged into 10min with 3000 revs/min of speed.Take its supernatant respectively by According to kit specification measure mice serum in TC (serum total cholesterol), TG (triglycerides) HDL (high-density lipoprotein), LDL (low-density lipoprotein), the content of TC, TG, GSH-Px (glutathione peroxidase) in liver homogenate.
Statistical method experimental data with SPSS21.0 statistical softwares handle, data withIt indicates, comparison among groups use t It examines.
3. experimental result
3.1 pairs of high lipid diets cause the influence of mouse obese model weight
1 essential oil external application of the present invention of table causes high lipid diet the influence of mouse obese model weight
Note：* is p<0.01, * p<0.05
5 groups of high lipid food is given, with blank group ratio, all high lipid food group mouse weights dramatically increase (P<0.01), That is modeling success.Weight no significant difference between modeling each group.After administration 20 days, with blank group ratio, model group body weight significantly increases Add；With model group ratio, large and small dosage essential oil of the present invention and Jiangzhi Jianfei Tablets group can significantly reduce high lipid diet and cause mouse fat Weight (the P of model<0.01).
3.2 pairs of high lipid diets cause the influence of mouse obese model liver index and Lee ' s indexes
Influence of the 2 essential oil external application of the present invention of table to obese model mouse liver index and Lee ' s indexes
Note：* is p<0.01, * p<0.05
Compared with blank group, model group liver weight, liver index, Lee ' s indexes significantly increase (P<0.01).With mould Type group is compared, and large and small dosage essential oil group of the present invention and Jiangzhi Jianfei Tablets group can significantly reduce liver weight and Lee ' s indexes (P <0.01)；Low dose of essential oil group of the present invention and Jiangzhi Jianfei Tablets group can significantly reduce liver index (P<0.01), large dosage sheet Invention essential oil group can obviously reduce liver index (P<0.05).
3.3 pairs of high lipid diets cause the influence of mouse obese model serum TC, TG, HDL, LDL level
Influence of the 3 essential oil external application of the present invention of table to TC, TG, HDL, LDL level in obese model mice serum
Note：* is p<0.01, * p<0.05
Compared with blank group, model group mice serum TC, TG, LDL are horizontal significantly to increase (P<0.01), serum HDL levels Significantly reduce (P<0.01), illustrate modeling success.Compared with model group, large and small dosage essential oil group of the present invention and Jiangzhi Jianfei Tablets Group can significantly reduce TC and LDL levels (P in mice serum<0.01)；Large dosage essential oil group of the present invention can significantly reduce TG water Flat (P<0.01), low dose of essential oil group of the present invention and Jiangzhi Jianfei Tablets group can obviously reduce TG levels (P in mice serum< 0.05)；Large and small dosage essential oil group of the present invention can significantly raised serum LDL levels (P<0.05), Jiangzhi Jianfei Tablets group can significantly rise High serum LDL levels (P<0.01).
3.4 pairs of high lipid diets cause the influence of mouse obese model liver homogenate TC, TG, GSH-Px level
Influence of the 4 essential oil external application of the present invention of table to TC, TG, GSH-Px level in obese model mouse liver
Note：* is p<0.01, * p<0.05
Compared with blank group, model group liver homogenate TC, TG is horizontal significantly to increase (P<0.01), liver homogenate GSH-Px levels are aobvious Writing reduces (P<0.01), illustrate modeling success.Compared with model group, large and small dosage essential oil group and Jiangzhi Jianfei Tablets group can be shown Writing reduces liver homogenate TC levels (P<0.01)；Large dosage essential oil group of the present invention can significantly reduce liver homogenate TG levels (P<0.01), Low dose of essential oil group of the present invention and Jiangzhi Jianfei Tablets group can obviously reduce liver homogenate TG levels (P<0.05)；Large dosage of present invention essence Oily group can significantly increase liver homogenate GSH-Px levels (P<0.01), low dose of essential oil group of the present invention and Jiangzhi Jianfei Tablets group can be apparent Increase liver homogenate GSH-Px levels (P<0.05).
4. brief summary
High lipid diet can cause mouse obese model.The continuous external application in 20 days of essential oil of the present invention, can significantly improve mouse obesity feelings Condition；The weight that high lipid diet causes mouse obese model can be significantly reduced；Essential oil of the present invention can significantly reduce liver weight and Lee ' s Index can significantly reduce liver index；It is horizontal that essential oil of the present invention can significantly reduce mice serum TC, TG, LDL, hence it is evident that increases blood Clear LDL is horizontal；Essential oil of the present invention can significantly reduce liver homogenate TC, TG level, and it is horizontal can significantly to increase liver homogenate GSH-Px.
Two, clinical test
Extraordinary advantageous effects are achieved on the basis of animal experiment ensures safety, and through clinical test, are had Pass data is as follows：
1, the standard of case is selected
Obesity refers to that body fat accumulation is excessive and (or) abnormal distribution, the 20% of the weight that is above standard, and without apparent The inner-sphere reorganization energy cause of disease；It is all that there is above-mentioned symptom, the selection criteria as obeisity patient.
2, diagnostic criteria：
Weight is above standard the 20% of weight after testing, and does not find the apparent inner-sphere reorganization energy cause of disease, diagnosable to be Obeisity, and give drug therapy of the present invention.Specifically：Reference《Chinese Adult is overweight and obesity prevention and control guide (on probation)》According to body mass index method BMI (kg/m2)=weight (kg)/[height m)]2.BMI is diagnosis obesity important indicator.It is super Weight BMI=24~29.9, Mild Obesity；BMI=30~34.9, central obesity；BMI=35~39.9, severe simple obesity；BMI≥ 40, male's waistline is more than or equal to 85ccm and women waistline is more than or equal to 80cm, is Central obesity.All cases are light, moderate It is fat.
Exclusion criteria：Gestation or women breast-feeding their children.Secondary Obesity disease.It cannot take medicine by regulation.
3, therapeutic scheme
It is all to suffer from simple obesity to making a definite diagnosis, essential oil treatment of the present invention is given, and in treatment while setting control group.
Of the present invention group applies abdomen, twice a day, each 0.1ml/cm using essential oil of the present invention2, 2 months as a treatment course. Control group takes melbine 0.25g, and daily 1, the course for the treatment of is of the present invention group same, and curative effect is counted after a course for the treatment of.
4, efficacy assessment standard
The evaluation criteria execution of the effect of simple obesity.It is effective：The course for the treatment of terminates weight loss and is more than or equal to 5kg, related Symptom disappears substantially.Effectively：The course for the treatment of terminates weight loss and is more than or equal to 3kg, and related symptom mitigates.In vain：The course for the treatment of terminates weight Do not decline, related symptom does not mitigate, or even has the trend of exacerbation.
5, statistical procedures：
It is all from patient medical history through 56 simple obesities to making a definite diagnosis, meets the diagnostic criteria of simple obesity, at random It is divided into of the present invention group and control group.Of the present invention group 28, man 18, female 10；Age is 13 years old minimum, 46 years old maximum.Control group 28, man 16, female 12；Age is 14 years old minimum, 46 years old maximum.After treatment, statistical procedures are as a result, of the present invention group 28 Example, effective 16 (57.1), effective 11 (39.3%), invalid 1 (3.6%), total effective rate 96.4%.Control group 28, Effective 10 (35.7%), effective 10 (35.7%), invalid 6 (21.4%), total effective rate 71.4%, of the present invention group apparent Better than control group, and during treatment, any toxic side effect or adverse reaction are found no, shows that drug safety, curative effect are steady It is fixed reliable.
6, conclusion
It is clear above to show that essential oil compatibility of the present invention is scientific and reasonable, abundant raw material, manufacture easy to produce, easy to use, effect It is good, there is the effect of weight-reducing, high efficiency has no toxic side effect up to 96% or more, is weight-reducing, treatment Obesity disease drug On innovation, have significant economic and social benefit.

Claims (6)

1. a kind of essential oil having antiobesity action, it is characterized in that：It is by following volumes meter：P-Cymene 8-12ml, datura flower essence Oily 13-17ml, semen brassicae essential oil 4-6ml, rheum officinale essential oil 8-12ml, Fructus Foeniculi quintessence oil 8-12ml, Peppermint essential oil 8-12ml, capsicum Essential oil 4-6ml is uniformly mixed and is made；
The P-Cymene is that folium artemisiae argyi was ground into the coarse powder of 10~20 mesh sieve, supercritical CO2Fluid extraction, feed liquid weight Volume ratio 1:10~20, w/v refers to solid in terms of g, and liquid is in terms of mL, 42~50 DEG C of extraction temperature, extracting pressure 20 ~25MPa, 50~60 DEG C, 4.5~5.5MPa of separating pressure, 1.5~2.5h of extraction time of separation temperature obtain P-Cymene；
The datura flower essential oil, semen brassicae essential oil, rheum officinale essential oil, Fructus Foeniculi quintessence oil, Peppermint essential oil, capsicum oil preparation method Same P-Cymene.
2. the essential oil according to claim 1 for having antiobesity action, it is characterized in that：It is by following volumes meter：P-Cymene It is 10ml, datura flower essential oil 15ml, semen brassicae essential oil 5ml, rheum officinale essential oil 10ml, Fructus Foeniculi quintessence oil 10ml, Peppermint essential oil 10ml, peppery Green pepper essential oil 5ml is uniformly mixed and is made.
3. the essential oil according to claim 1 for having antiobesity action, it is characterized in that：It is by following volumes meter：P-Cymene 8ml, datura flower essential oil 13ml, semen brassicae essential oil 4ml, rheum officinale essential oil 8ml, Fructus Foeniculi quintessence oil 8ml, Peppermint essential oil 8ml, chilli extract Oily 4ml is uniformly mixed and is made.
4. the essential oil according to claim 1 for having antiobesity action, it is characterized in that：It is by following volumes meter：P-Cymene It is 12ml, datura flower essential oil 17ml, semen brassicae essential oil 6ml, rheum officinale essential oil 12ml, Fructus Foeniculi quintessence oil 12ml, Peppermint essential oil 12ml, peppery Green pepper essential oil 6ml is uniformly mixed and is made.
5. the essential oil according to claim 1 for having antiobesity action, it is characterized in that：It is by following volumes meter：P-Cymene 12ml, datura flower essential oil 13ml, semen brassicae essential oil 6ml, rheum officinale essential oil 8ml, Fructus Foeniculi quintessence oil 12ml, Peppermint essential oil 8ml, capsicum Essential oil 6ml is uniformly mixed and is made.
6. the essential oil according to claim 1 for having antiobesity action, it is characterized in that：It is by following volumes meter：P-Cymene 8ml, datura flower essential oil 17ml, semen brassicae essential oil 4ml, rheum officinale essential oil 12ml, Fructus Foeniculi quintessence oil 8ml, Peppermint essential oil 12ml, capsicum Essential oil 4ml is uniformly mixed and is made.
CN201810915587.7A 2018-08-13 2018-08-13 A kind of essential oil having antiobesity action Withdrawn CN108635460A (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115644440A (en) * 2022-09-30 2023-01-31 华中科技大学协和深圳医院 Compound food flavoring agent and application thereof in obesity prevention and treatment

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103622863A (en) * 2012-08-24 2014-03-12 于明山 Preparation method of body shaping essential oil

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103622863A (en) * 2012-08-24 2014-03-12 于明山 Preparation method of body shaping essential oil

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
张旭: "减肥产品,不是想用就能用 ", 《中医健康养生》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115644440A (en) * 2022-09-30 2023-01-31 华中科技大学协和深圳医院 Compound food flavoring agent and application thereof in obesity prevention and treatment

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