CN102356876A - Health food for preventing and treating premature aging of women and preparation method thereof - Google Patents
Health food for preventing and treating premature aging of women and preparation method thereof Download PDFInfo
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- CN102356876A CN102356876A CN2011103036228A CN201110303622A CN102356876A CN 102356876 A CN102356876 A CN 102356876A CN 2011103036228 A CN2011103036228 A CN 2011103036228A CN 201110303622 A CN201110303622 A CN 201110303622A CN 102356876 A CN102356876 A CN 102356876A
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Abstract
The invention discloses a health food for preventing and treating the premature aging of women and a preparation method thereof. The health food is prepared from the following ingredients in parts by weight: 10-15 parts of wolfberry, 10-15 parts of glossy privet fruit, 10-15 parts of prepared rehmannia root, 15-20 parts of radix ophiopogonis, 10-15 parts of fructus psoraleae, 10-15 parts of angelica sinensis, 10-15 parts of coix seed, 20-30 parts of beef extract, 20-30 parts of spina date seed and 2-3 parts of soy isoflavone. By adopting the health food, the function of the ovary can be improved, the growth of the ovarian follicle can be enhanced, the action of the estrogen sample can be exerted and the osteoporosis can be prevented.
Description
Technical field
The present invention relates to a kind of health food and preparation method thereof, specifically a kind of health food of preventing and treating women's early ageing and preparation method thereof.
Background technology
The women is before 40 years old; Because the rising and the estrogenic decline of promoting sexual gland hormone level; Amenorrhoea and sexual organ atrophy appear; Often have, the clinical manifestation companion sees the relevant symptom of menopausal syndrome: like ovarian function decline, micromazia, irregular menstruation, osteoporotic clinical manifestation, and women's early ageing that Here it is often says.
Doctor trained in Western medicine is thought the related diseases of women's early ageing because of complicacy, and its pathogenesis it be unclear that, and treats also quite thorny.The cause of disease that has realized that at present has inherent cause, immune factor, iatrogenic factors, environment and infective agent; Psychological factor, but most of women's early ageing cause of disease is unclear, belongs to the special property sent out women early ageing; In recent years, local multiple-factor regulating system of ovary or network imbalance possibly cause women's early ageing.
At present doctor trained in Western medicine adopts HRT for women's early ageing, and keeping menstruation, sex character, sexual function, but hormone therapy has significant side effects.
Women's early ageing is the expressed symptom of a kind of doctor trained in Western medicine; The traditional Chinese medical science does not give corresponding name of disease; With women's early ageing certain relation is arranged among the diseases such as " hypomenorrhia ", " delayed menstrual cycle ", " amenorrhoea ", " blood depletion ", " infertile ", " menopause before climacteric " in the traditional Chinese medical science ancient books, adopt the method for empty, the easypro liver depression of kidney tonifying, change blood stasis to treat more.But women's early ageing is a kind of chronic disease, uses Chinese medicine also can injure taste for a long time, and therefore, the health products that the present invention adopts the medicine food to combine are prevented and treated women's early ageing, and avoid using merely the injury of Chinese medicine to taste.
Summary of the invention
Goal of the invention: first purpose of the present invention is to provide a kind of health food of the women's of control early ageing, and this health food has certain effect to women's early ageing symptoms such as ovarian function decline, micromazia, irregular menstruation, osteoporosises.
Two of the object of the invention: the preparation method that a kind of health food of the women's of control early ageing is provided.
Technical scheme
The technical scheme that the present invention adopted is: a kind of health food of the women's of control early ageing, it comprises that the raw material of following weight portion forms: matrimony vine 10-15 part, fruit of glossy privet 10-15 part, prepared rhizome of rehmannia 10-15 part, the tuber of dwarf lilyturf 15-20 part, Psoralea corylifolia 10-15 part, Radix Angelicae Sinensis 10-15 part, SEMEN COICIS 10-15 weight portion, beef extract 20-30 weight portion, spina date seed 20-30 weight portion, isoflavones 2-3 weight portion.
The formulation of said health food comprises oral liquid, granule, paste, tablet and pill.
In order to solve above-mentioned second purpose, the technical scheme that the present invention adopted is:
A kind of preparation method who prevents and treats the health food of women's early ageing, it may further comprise the steps:
Take by weighing each raw material, subsequent use;
It is alcohol immersion 6-8 hour of 10-95% that each raw material of said weight proportion is added volumetric concentration, refluxing extraction 2-3 hour then, refilters filtrate for later use;
Filtrating concentrates, and drying promptly gets the active component of said health food.
Prevent and treat the preparation method of the health food of women's early ageing, it is characterized in that, the adding weight of ethanol is 20 times of raw material gross weight.
The specific embodiment
Embodiment 1
A kind of health food of preventing and treating women's early ageing, it is made up of the raw material of following weight portion: 10 parts of matrimony vines, 10 parts of the fruit of glossy privets, 10 parts of prepared rhizomes of rehmannia, 15 parts of the tubers of dwarf lilyturf, 10 parts of Psoralea corylifolias, 10 parts of Radix Angelicae Sinensis, SEMEN COICIS 10 weight portions, beef extract 20 weight portions, spina date seed 20 weight portions, isoflavones 2 weight portions.
Embodiment 2
A kind of health food of preventing and treating women's early ageing, it comprises the raw material of following weight portion: 15 parts of matrimony vines, 15 parts of the fruit of glossy privets, 15 parts of prepared rhizomes of rehmannia, 20 parts of the tubers of dwarf lilyturf, 15 parts of Psoralea corylifolias, 15 parts of Radix Angelicae Sinensis, SEMEN COICIS 15 weight portions, beef extract 30 weight portions, spina date seed 30 weight portions, isoflavones 3 weight portions.
Embodiment 3
A kind of preparation method who prevents and treats the health food of women's early ageing takes by weighing experimental example 1 each raw material, and is subsequent use;
It is 75% alcohol immersion 7 hours that each raw material of said weight proportion is added volumetric concentration, and refluxing extraction is 2 hours then, refilters filtrate for later use; Filtrating concentrates, and drying promptly gets the active component of said health food.
Embodiment 4
A kind of preparation method who prevents and treats the health food of women's early ageing takes by weighing experimental example 2 each raw material, and is subsequent use;
It is 30% alcohol immersion 10 hours that each raw material of said weight proportion is added volumetric concentration, and refluxing extraction is 3 hours then, refilters filtrate for later use; Filtrating concentrates, and drying promptly gets the active component of said health food.
Embodiment 5
A kind of preparation method who prevents and treats the health food of women's early ageing takes by weighing experimental example 2 each raw material, and is subsequent use;
It is 95% alcohol immersion 6 hours that each raw material of said weight proportion is added volumetric concentration, and refluxing extraction is 2 hours then, refilters filtrate for later use; Filtrating concentrates, and drying promptly gets the active component of said health food.
Embodiment 6
Take by weighing the active component of the health food of experimental example 3, put in the batch tank, add Sodium Benzoate, Arabic syrup, honey, distilled water, make oral liquid.
Embodiment 7
Take by weighing the active component of the health food of experimental example 4, added Icing Sugar, the cyclodextrin of 80 mesh sieves, mixing adds binder, and the system softwood is granulated, 60 ℃ of dryings, whole grain, makes granule.
Embodiment 8
Take by weighing the active component of the health food of experimental example 5, add refined honey, mix in 5: 1 ratio, adopt pellet processing machine with active component, the pill bar, pill makes pill.
Embodiment 9
The acute toxicity tests shows:
The rat oral gavage maximum dosage-feeding of the oral liquid of embodiment 6 is 100g/kg/d
(, calculating) according to the weight/rat weight of medicinal raw material.
Experiment does not see that animal has obvious poisoning symptom and reaction.
Embodiment 10
Experiment material:
Galactolipin feed: the D-galactolipin is sneaked in the common rat feed by 35% concentration.
Animal used as test: 50 of Healthy female SD rats, in 10 ages in week, body weight 200～250g raises in temperature 23-25 ℃, and relative humidity is 50～60%, freely intakes, feed, every day, light application time was 12h, carried out adaptability and raised.
Experimental technique:
After adaptability is raised a week, 50 rats are divided into 5 groups at random, every group each 10, are respectively blank group, model group, oral liquid group, granule group, pill group.
Model group rat feeding 35%D-galactolipin feed carries out modeling,
Other group rat feeding normal rat feeds.
Blank group and model group rat are irritated stomach 2 times with physiological saline every day,
Oral liquid group rat is got oral liquid and irritates stomach 2 times every day,
Oral liquid group, granule group, pill group rat, the corresponding formulation of health food of going bail for is respectively irritated stomach every day 2 times with an amount of physiological saline dilution dissolving.
Each organizes health food filling stomach dosage is standard with the medium dosage of people, amounts to into rat dosage.Be to contain raw material 12g in the health food of every kilogram of rat oral gavage.
After the grouping, weigh, write down every group of rat body weight; Later on each all weighing and recording is once tested after 60 days and is closed to an end, and weighs once more and record.
Give the execution of cervical vertebra dislocation method with getting blood rat afterwards, get ovary, give scales/electronic balance weighing.Calculate its ovary index: ovary index=ovary weight/body weight.
After weighing, ovary uses formalin fixed, after the gradient alcohol dehydration, and the routine paraffin wax embedding, section, after the HE dyeing, light microscopic is observed the tectology variation of ovary down.
Since modeling in the 1st day the last about the 30th day, the model group rat, the movable minimizing, reaction slows down, and depilation occurs, and hair color is dim, and feel is moist, hidrosis, amount of drinking water rises, and body weight gain is starkly lower than blank.This shows the modeling success.
The body weight observed result is seen table 1
Table 1 is respectively organized rat body weight and is changed
| Group | n | Body weight g (before the experiment) | Body weight g (experiment back) |
| The blank group | 10 | 220.30±20.10 | 330.13±15.36 |
| Model group | 10 | 225.17±17.32 ▲ | 245.78±11.57 ★ |
| The oral liquid group | 10 | 218.58±23.78 ▲ | 312.78±14.38 ▲★ |
| The granule group | 10 | 223.93±19.70 ▲ | 309.25±17.89 ▲★ |
| The pill group | 10 | 217.90±15.56 ▲ | 305.22±20.17 ▲★ |
Annotate:
▲Representative is compared P＞0.05 with the blank group,
*Representative is compared P＜0.05 with the blank group,
★Representative is compared P＜0.05 with model group
Respectively organize the rat body weight there was no significant difference, P＞0.05 before can finding out experiment by table 1.When experiment finished, the model group rat body weight significantly was lower than the blank group, P＜0.05; Each health food group rat body weight is significantly higher than the model group rat, P＜0.05; And each health food group rat body weight is compared there was no significant difference with the blank group, P＞0.05.
Embodiment 11 respectively organizes the rat ovary index contrast
Experimental technique is respectively organized the rat ovary index contrast with reference to embodiment 10
| Group | n | (* 10 for the ovary index -3) |
| The blank group | 10 | 0.357±0.031 * |
| Model group | 10 | 0.159±0.021 ▲★ |
| The oral liquid group | 10 | 0.231±0.019 ▲★ |
| The granule group | 10 | 0.214±0.015 ▲★ |
| The pill group | 10 | 0.198±0.020 ▲★ |
Annotate:
▲Representative is compared P＞0.05 with the blank group,
*Representative is compared P＜0.05 with the blank group,
★Representative is compared P＜0.05 with model group
Each is organized the rat ovary index and sees table 2.When experiment finished, model group was compared the ovary index with the blank group and is obviously reduced P＜0.05; Each health food group ovary index has significant difference, P＜0.05 apparently higher than model group; And each health food group and blank group ovary index there was no significant difference, P＞0.05.
Embodiment 12 respectively organizes the contrast of rat ovary morphology
The contrast of embodiment 13 clinical observation on the therapeutic effect
Clinical observation on the therapeutic effect to women's 40 examples of treatment type of deficiency of both QI and YIN dysmenorrhoea and ovarian atrophy
Be divided into 2 groups at random, test group 20 examples, Colla Corii Asini nourishing blood oral liquid control group 20 examples
Test group is taken oral liquid of the present invention, Colla Corii Asini nourishing blood oral liquid, 3 times on the one; Be 2 months the course of treatment.During medication, forbid taking the other drug relevant with treating this disease.
Criterion of therapeutical effect is from the plan standard,
Recovery from illness: after treatment, recover.
Produce effects: after treatment, dysmenorrhoea obviously reduces, and it is normal that MBV recovers, and swollen breasts obviously reduces, and abnormal sweating reduces, and ovary recovers, not constipation.
Take a turn for the better: after treatment, dysmenorrhoea reduces, and MBV partly recovers normally, and swollen breasts reduces, and abnormal sweating reduces, and ovary partly recovers, not constipation.
Invalid: after treatment, dysmenorrhoea does not reduce, and MBV is few, and swollen breasts does not reduce, and abnormal sweating does not reduce, and ovary does not recover, constipation.
Preliminary Clinical Observation through 60 days,
Oral liquid clinical cure rate 75% of the present invention, total effective rate are 90%, 73 yuan of costs;
The cure rate 70% of Colla Corii Asini nourishing blood oral liquid, total effective rate are 88%, 175 yuan of costs;
Preparation of the present invention has instant effect, and short term effect is remarkable, the tangible characteristics of remote effect, and also competitively priced, be worthy to be popularized.
Claims (2)
1. health food of preventing and treating women's early ageing; It is characterized in that it is made up of the raw material of following weight portion: matrimony vine 10-15 part, fruit of glossy privet 10-15 part, prepared rhizome of rehmannia 10-15 part, the tuber of dwarf lilyturf 15-20 part, Psoralea corylifolia 10-15 part, Radix Angelicae Sinensis 10-15 part, SEMEN COICIS 10-15 weight portion, beef extract 20-30 weight portion, spina date seed 20-30 weight portion, isoflavones 2-3 weight portion.
2. a kind of health food of preventing and treating women's early ageing according to claim 1 and 2 is characterized in that the formulation of said health food is oral liquid, granule, paste, tablet and pill.
3. a kind of preparation method who prevents and treats the health food of women's early ageing according to claim 1 and 2 is characterized in that following steps:
Take by weighing each raw material, subsequent use;
It is alcohol immersion 6-8 hour of 10-95% that each raw material of said weight proportion is added volumetric concentration, refluxing extraction 2-3 hour then, refilters filtrate for later use;
Filtrating concentrates, and drying promptly gets the active component of said health food.
4. a kind of preparation method who prevents and treats the health food of women's early ageing according to claim 4 is characterized in that, the adding weight of ethanol is 20 times of raw material gross weight.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103599357A (en) * | 2013-12-05 | 2014-02-26 | 丛建香 | Traditional Chinese medicine for treating premature ovarian failure |
| CN106963845A (en) * | 2017-06-02 | 2017-07-21 | 四川和济健康管理有限公司 | It is a kind of to be used to protect female to prolong the Chinese medicine composition in spring and preparation method thereof |
| CN107307398A (en) * | 2017-05-16 | 2017-11-03 | 柳州联云科技有限公司 | A kind of female health food |
| CN107772438A (en) * | 2016-08-24 | 2018-03-09 | 江苏康缘药业股份有限公司 | A kind of health-care food composition for promoting follicular development and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1539459A (en) * | 2003-10-30 | 2004-10-27 | 吉林省辽源亚东药业股份有限公司 | Chinese materia medica preparation of recreating blood for curing anaemia and producing method |
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- 2011-10-09 CN CN2011103036228A patent/CN102356876B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1539459A (en) * | 2003-10-30 | 2004-10-27 | 吉林省辽源亚东药业股份有限公司 | Chinese materia medica preparation of recreating blood for curing anaemia and producing method |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103599357A (en) * | 2013-12-05 | 2014-02-26 | 丛建香 | Traditional Chinese medicine for treating premature ovarian failure |
| CN103599357B (en) * | 2013-12-05 | 2015-07-08 | 丛建香 | Traditional Chinese medicine for treating premature ovarian failure |
| CN107772438A (en) * | 2016-08-24 | 2018-03-09 | 江苏康缘药业股份有限公司 | A kind of health-care food composition for promoting follicular development and preparation method thereof |
| CN107772438B (en) * | 2016-08-24 | 2021-04-06 | 江苏康缘药业股份有限公司 | Health food composition for promoting follicular development and preparation method thereof |
| CN107307398A (en) * | 2017-05-16 | 2017-11-03 | 柳州联云科技有限公司 | A kind of female health food |
| CN106963845A (en) * | 2017-06-02 | 2017-07-21 | 四川和济健康管理有限公司 | It is a kind of to be used to protect female to prolong the Chinese medicine composition in spring and preparation method thereof |
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| CN102356876B (en) | 2013-02-20 |
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