CN108567902A - A kind of the progestogenic purposes and preparation method of integration of drinking and medicinal herbs formula - Google Patents
A kind of the progestogenic purposes and preparation method of integration of drinking and medicinal herbs formula Download PDFInfo
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- A61K36/88—Liliopsida (monocotyledons)
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Abstract
The present invention provides a kind of progestogenic purposes of integration of drinking and medicinal herbs Chinese medicine composition of progestogenic and preparation method thereof, and raw material is：20 parts of sealwort, 20 parts of Chinese yam, 18 parts of the fruit of Chinese wolfberry, 18 parts of raspberry, 15 parts of air bladder, 3 parts of Radix Angelicae Sinensis, 6 parts of peach kernel, 20 parts of Poria cocos, 6 parts of cloves, 6 parts of proportioning prescriptions of fennel seeds, excipient, adhesive, appropriate corrigent；Its technological design is reasonable, and optimization aim is clear, and process conditions prediction is accurate, and quality control main contents include granularity, melting, dry extract total starches content, it is ensured that the safety of the Chinese medicine composition clinical application and validity ensure that product quality is stably and controllable.
Description
Technical field
The invention belongs to field of food, and in particular to a kind of integration of drinking and medicinal herbs granule, the integration of drinking and medicinal herbs formula of progestogenic and
Its process for producing granula and purposes.
Background technology
Kidney deficiency blood stasis is to lead to infertile one of the major reasons, and main pathogenesis is deficiency of kidney-essence, stagnation of blood stasis.It
The adjusting in the last of the ten Heavenly stems, the normal cycle of menses are all dominated by kidney qi.If deficiency of kidney-QI, the reasons such as kidney essense is unreal can all cause kidney deficiency.Gas
For the general of blood, the deficiency of vital energy or the stagnation of the circulation of vital energy are to lead to the cause of disease of hematogenous blockage, and then generate the performance of blood stasis correlation syndrome.Kidney deficiency and blood stasis
Reciprocal causation forms vicious circle, leads to more serious consequence at last, and many ill symptoms occur if adjusting not in time.
Modern society's life rhythm is fast, and pressure is big, once finding to suffer from infertility, does not know about oneself physical condition, and just patient does not choose the doctor,
Such case seriously affects the physical and mental health of Contemporary Female.
The infertile research of compound of Chinese herbal medicine at present is extremely abundant, main method be by dialectical, will be infertile
There are many card types, are cured with corresponding prescription.Progestogenic side is clinically mostly used with decoction, is existed in transport and storage
It is many inconvenient, and taking dose is big, it has not been convenient to and factory produces in batches, has prodigious limitation to the use of classics side.The present invention
This side is developed into the granule being closer to decoction in preparation method, can unit dose package, not only save original in this way
The feature and advantage of side, more clinical patients are provided convenience, and the dosage taken is accurately controllable.
To ensure safety and the validity of the invention Chinese medicine composition medication, ensures product quality, quality control need to be carried out
System.The present invention determines the method for the Chinese medicine composition quality control main contents include the property by taking granule as an example
Shape, discriminating, inspection and assay.
Invention content
The object of the present invention is to provide a kind of progestogenic purposes of integration of drinking and medicinal herbs formula and preparation methods.
The present invention provides a kind of integration of drinking and medicinal herbs Chinese medicine composition of progestogenic, it is characterised in that：Bulk pharmaceutical chemicals are：20 parts of sealwort,
20 parts of Chinese yam, 18 parts of the fruit of Chinese wolfberry, 18 parts of raspberry, 15 parts of air bladder, 3 parts of Radix Angelicae Sinensis, 6 parts of peach kernel, 20 parts of Poria cocos, 6 parts of cloves, fennel fruit
It is 6 parts fragrant；Described part is parts by weight；
(1) prepare each bulk pharmaceutical chemicals according to the parts by weight；
(2) it takes (1) raw material to add 6-10 times of water, extracts 1-2 hours, extract 1-3 times, merge extracting solution；
(3) (2) extracting solution is taken, the medicinal extract of relative density 1.20-1.25 is measured when being concentrated into 25 DEG C, obtains extraction medicinal extract；
(4) (3) medicinal extract is taken, drying, 60 DEG C of drying temperature, pressure 0.08-0.09MPa in vacuum drying chamber is set and obtains dry leaching
Dry extract crushed 80 mesh sieve, obtains extract powder by cream；
(5) (4) extract powder is mixed with auxiliary material, using wet granulation, corrigent, adhesive is added；By optimised process, i.e.,
Medicinal material dry extract：Excipient=1：0.75, corrigent 1-2 ‰, mixing, described part are parts by weight；Softwood processed is pelletized, and is done
Dry, whole grain is to get granule；
(6) it checks：It should meet《Pharmacopoeia of People's Republic of China》2015 editions four (ruless of preparations), it is related each under particle item
Item regulation.
(7) paste-forming rate measures：Precision absorption solution to be determined, which is set, have been dried into the evaporating dish of constant weight, in 60 DEG C of baking ovens
12h is dried to constant weight, is moved in drier rapidly, and rapid accurately weighed quality, each with dry product Mass Calculation after being cooled to room temperature
The paste-forming rate of respective conditions.
According to《Pharmacopoeia of People's Republic of China (2015 editions)》In requirement to granule, particulate samples obtained are carried out
Run-of-the-mill inspection, including granularity, melting, dry extract total starches content, and evaluated.
(1) granularity：Using wet granulation, by optimised process, i.e. medicinal material dry extract：Edible dextrin=1:0.75 mixing,
Appropriate Sucralose, using 90% ethyl alcohol as wetting agent, softwood processed, sieving granulation, forced air drying particle, weighing can be calculated average
Granularity qualification rate is 87.81%, and particle is made and meets requirement of 2015 editions pharmacopeia to granule granularity.
(2) melting：Obtained particle test sample 10g is taken, water 200mL is heated, 5min is stirred, observes immediately, it is seen that particle
There is slight turbid, without breeze, particle is made and meets requirement of 2015 editions pharmacopeia to granule melting.
(3) dry extract total starches assay：
It is prepared by reference substance solution：Precision weighs 105 DEG C of dryings to the glucose 9.8mg of constant weight, sets in 100mL volumetric flasks,
With distillation water dissolution and it is diluted to scale, as a contrast product solution.
The preparation of test solution：Precision weighs medicinal extract powder 49.7mg, is placed in 50mL volumetric flasks, is diluted with distilled water
To scale, as test solution.
The drafting of standard curve：Precision draws reference substance solution 0.2,0.4,0.6,0.8,1.0mL, sets 10mL capacity respectively
In bottle, phenol solution 1.6mL is added, is rapidly added concentrated sulfuric acid 6.0mL, it is 10mL to add water to total volume, is shaken up, and 15min is stood.
It is operated using distilled water as blank control with method, trap is measured at 490nm.With concentration (X) for abscissa, trap (Y)
For ordinate, standard curve is drawn.
Medicinal extract total starches assay：Accurate measurement sample polysaccharide concentrate 0.20mL, it is same by bioassay standard curve
Its absorbance is surveyed in method operation.
It can sample polyoses content be directly after readout process from standard curve：0.01046mg/mL is calculated and is understood leaching
Polyoses content in cream powder is 51.22%.
The present invention provides a kind of integration of drinking and medicinal herbs granule of progestogenic, and bulk pharmaceutical chemicals are：20 parts of sealwort, 20 parts of Chinese yam, matrimony vine
18 parts of son, 18 parts of raspberry, 15 parts of air bladder, 3 parts of Radix Angelicae Sinensis, 6 parts of peach kernel, 20 parts of Poria cocos, 6 parts of cloves, 6 parts of fennel seeds；Described part
It is parts by weight；
The present invention Chinese medicine be it is a kind of adjusting kidney deficiency, progestogenic Empirical formula, be that inventor sends out in experience of practising medicine for many years
Bright, compatibility is reasonable, by clinical verification, has preferable clinical effectiveness, by sealwort, Chinese yam, the fruit of Chinese wolfberry, raspberry, fish
Fish glue, Radix Angelicae Sinensis, peach kernel, Poria cocos, cloves, fennel seeds composition, sealwort is sweet in flavor, mild-natured, have boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney-nourishing it
Effect；Chinese yam is sweet in flavor, mild-natured, has the effect of tonifying spleen nourishing the stomach, engender liquid and benefic lung, kidney tonifying is puckery smart；The fruit of Chinese wolfberry is sweet in flavor, mild-natured, has
It is nourishing liver and kidney, the effect of benefiting shrewd head；Air bladder is sweet in flavor, mild-natured, has tonifying kidney and benefiting sperm, nourishes tendon and vessel, and hemostasis dissipates the stasis of blood, subsides a swelling it
Effect；Radix Angelicae Sinensis is sweet in flavor, pungent, warm-natured, has replenishing and activating blood, menstruction regulating and pain relieving, the effect of relaxing bowel, five bring out the best in each other.Match again
With Poria cocos, raspberry, peach kernel, cloves and fennel seeds, this medicine is mild.And our drug comes under integration of drinking and medicinal herbs type drug, safety
Property it is relatively high, be applicable in the long-term adjustment of correlated crowd and treatment.
Chinese medicine composition of the present invention is by taking bead dosage form as an example, foundation and respect clinical application mode, simple production process,
Granule that the preparation method obtains effectively, process stabilizing, quality it is uniform.
The present invention is to ensure safety and the validity of the invention Chinese medicine composition medication, ensures product quality, to this
The method of Chinese medicine composition quality control determined, main contents include granularity, melting, dry extract total starches content,
And evaluated, the quality of the Chinese medicine composition is controlled comprehensively.
Description of the drawings
Fig. 1 determination of polysaccharide standard curves
Specific implementation mode
It reiterates：Following methods are only the method for quality control by taking granule as an example, are not covered by and are exhausted this hair
Bright all dosage forms, it is therefore intended that illustrate Chinese medicine composition preparation process of the present invention and method of quality control with data, it is qualitative and
Quantitative analysis index and method.
Embodiment 1：A kind of preparation of the integration of drinking and medicinal herbs Chinese medicine composition of progestogenic
Raw material is：20 parts of sealwort, 20 parts of Chinese yam, 18 parts of the fruit of Chinese wolfberry, 18 parts of raspberry, 15 parts of air bladder, 3 parts of Radix Angelicae Sinensis, peach kernel 6
Part, 20 parts of Poria cocos, 6 parts of cloves, 6 parts of fennel seeds；Described part is parts by weight；
(1) prepare each bulk pharmaceutical chemicals according to the parts by weight；
(2) it takes (1) raw material to add 6-10 times of water, extracts 1-2 hours, extract 1-3 times, merge extracting solution；
(3) (2) extracting solution is taken, the medicinal extract of relative density 1.20-1.25 is measured when being concentrated into 25 DEG C, obtains extraction medicinal extract；
(4) (3) medicinal extract is taken, drying, 60 DEG C of drying temperature, pressure 0.08-0.09MPa in vacuum drying chamber is set and obtains dry leaching
Dry extract crushed 80 mesh sieve, obtains extract powder by cream；
(5) (4) extract powder is mixed, preparations shaping with common dosage forms auxiliary material, obtains granule, capsule or tablet.
Embodiment 2：A kind of preparation of the integration of drinking and medicinal herbs Chinese medicinal composition granules of progestogenic
Raw material is：20 parts of sealwort, 20 parts of Chinese yam, 18 parts of the fruit of Chinese wolfberry, 18 parts of raspberry, 15 parts of air bladder, 3 parts of Radix Angelicae Sinensis, peach kernel 6
Part, 20 parts of Poria cocos, 6 parts of cloves, 6 parts of fennel seeds；Described part is parts by weight；
The Chinese herbal granules are made by following preparation method：
(1) prepare each bulk pharmaceutical chemicals according to the parts by weight；
(2) it takes (1) raw material to add 6-10 times of water, extracts 1-2 hours, extract 1-3 times, merge extracting solution；
(3) (2) extracting solution is taken, the medicinal extract of relative density 1.20-1.25 is measured when being concentrated into 25 DEG C, obtains extraction medicinal extract；
(4) (3) medicinal extract is taken, drying, 60 DEG C of drying temperature, pressure 0.08-0.09MPa in vacuum drying chamber is set and obtains dry leaching
Dry extract crushed 80 mesh sieve, obtains extract powder by cream；
(5) (4) extract powder is mixed with auxiliary material, using wet granulation, corrigent, adhesive is added；Medicinal material dry extract：
Filler=1：0.75, corrigent 1-2 ‰, mixing, described part are parts by weight；Softwood processed is pelletized, dry, whole grain to get
Granula；
Above-mentioned filler is dextrin；Wetting agent is 90% ethyl alcohol；Corrigent is Sucralose.
Embodiment 3：A kind of integration of drinking and medicinal herbs Chinese medicine composition qaudrature-homogeneous design of progestogenic
1. determination water is Extraction solvent, using L9 (34) it is orthogonal tested, select extraction time, extraction time, Jia Shui
Amount respectively takes 3 levels as 3 factors investigated, each factor again.(see Tables 1 and 2)
1 progestogenic side's extraction process orthogonal test factor level table of table
2 Orthogonal Experiment and Design of table
2. extraction process paste-forming rate measurement result：
Precision absorption solution to be determined, which is set, have been dried into the evaporating dish of constant weight, and baking 12h is fast to constant weight in 60 DEG C of baking ovens
Speed moves in drier, and rapid accurately weighed quality, goes out cream with each respective conditions of dry product Mass Calculation after being cooled to room temperature
Rate obtains following result.
3 progestogenic side's extraction process orthogonal experiments of table
4 paste-forming rate the results of analysis of variance of table
Note：F0.05(3,3)=195.47
By the range analysis of upper table the results show that three factors influence size order is：A ＞ B ＞ C.The results of analysis of variance is aobvious
Show that the influence that extraction time, extraction time plus water are measured again to result all has significant difference in selected horizontal extent.By pole
Difference analysis determines that the level of A factors is A3, B, C factor is determined as B according to produce reality, from the angle for saving energy consumption1、C1。
It is integrated by test result and determines that extraction conditions are A3B1C1, i.e. extracting in water 3 times, extraction time 1h, it is 6 to add water to measure again.
3. process certification is tested
Repetition test result, which is carried out, by the above optimised process is shown in Table 5.
5 optimum extraction process confirmatory experiment table of table
As seen from table, extraction process is stablized feasible.
Embodiment 4：A kind of integration of drinking and medicinal herbs Compatible Granule granulating process research of progestogenic
Wet granulation：20g dry extracts are taken, corresponding reagent and reagent is added, after softwood is made, cross 12 mesh galvanized wires
Sieve, granulation, manufactured particle, which is placed in 60 DEG C of baking ovens, dries 1h.
1. the selection of filler
Common filler：Dextrin, soluble starch, lactose
Preliminary result：
Dextrin is as auxiliary material softwood and particle situation：It is easier to that softwood is made, it is convenient that granular texture is made；
Soluble starch is as auxiliary material softwood and particle situation：Loosely, it is loose that granular texture is made in obtained softwood；
Lactose is as auxiliary material softwood and particle situation：It is easier to that softwood is made, obtained granular texture is convenient, but outside particle
Sight has white point；
It is by preliminary result it is found that preferable using dextrin granulation situation, and dextrin is cheap, is soluble in hot water, stabilization
The good, good fluidity of property, stability are preferable, therefore select dextrin for granulation auxiliary material.
2. concentration of alcohol (A) is investigated
Using dextrin as auxiliary material, when B is 35%, when C is 100%, A pelletizes situation when being respectively 70%, 85%, 90%.
6 different concentration ethanol of table granulation situation
(* indicates difficult granulation, and obtained particle is very little, and it is meaningless to calculate granularity qualification rate)
As shown in Table 6, when A be 90% when, can softwood and particle preferably processed, and grain forming obtained preferably, matter
Ground is convenient, relatively more uniform.
3. ethanol consumption (B) is investigated
Using dextrin as auxiliary material, when A is 90%, when C is 100%, granulation situation when B is respectively 30%, 35%, 40%.
The different ethanol consumption granulation situations of table 7
(B is with ethyl alcohol：Dried cream powder expression, %)
As shown in Table 7, when B be 40% when, can softwood and particle preferably processed, and grain forming obtained preferably, matter
Ground is convenient, relatively more uniform.
4. supplementary product consumption (C) is investigated
Using dextrin as auxiliary material, when A is 90%, when B is 40%, when C is respectively 75%, 100%, 125%, situation of pelletizing.
8 supplementary product consumption of table granulation situation
(C is with auxiliary material：Dried cream powder expression, %)
As shown in Table 8, when C be 75% when, can softwood and particle preferably processed, and grain forming obtained preferably, matter
Ground is convenient, relatively more uniform.
In summary 3 analysis of experimental results can preferably make it is found that when A is 90%, B is 40% when C is 75%
Softwood and particle, and grain forming obtained is preferable, quality is convenient, relatively more uniform.Therefore granulation conditions are chosen to be
A3B3C1。
5. process certification is tested
Repetition test result is carried out by the above optimised process see the table below.
9 pelletizing forming engineer testing of table
As seen from table, granulating process is stablized feasible.
Embodiment 5：A kind of Investigation of Quality Standard of the integration of drinking and medicinal herbs Compatible Granule of progestogenic
1. granularity：Using wet granulation, by optimised process, i.e. medicinal material dry extract：Edible dextrin=1：0.75 mixing, three
Chlorine sucrose is appropriate, and using 90% ethyl alcohol as wetting agent, softwood processed, sieving is pelletized, forced air drying particle, and weighing can be calculated average grain
It is 87.81% to spend qualification rate, and particle is made and meets requirement of 2015 editions pharmacopeia to granule granularity.
2. melting：Obtained particle test sample 10g is taken, water 200mL is heated, stirs 5min, observation immediately refers to table 10.
10 melting test situation table of table
As shown in Table 10, particle is made and meets requirement of 2015 editions pharmacopeia to granule melting.
3. dry extract total starches assay：
It is prepared by reference substance solution：Precision weighs 105 DEG C of dryings to the glucose 9.8mg of constant weight, sets in 100mL volumetric flasks,
With distillation water dissolution and it is diluted to scale, as a contrast product solution.
The preparation of test solution：Precision weighs medicinal extract powder 49.7mg, is placed in 50mL volumetric flasks, is diluted with distilled water
To scale, as test solution.
The preparation of standard curve：Precision draws reference substance solution 0.2,0.4,0.6,0.8,1.0mL, sets 10mL capacity respectively
In bottle, phenol solution 1.6mL is added, is rapidly added concentrated sulfuric acid 6.0mL, it is 10mL to add water to total volume, is shaken up, and 15min is stood.
It is operated using distilled water as blank control with method, trap is measured at 490nm.Determination data is shown in Table 11.It is cross with concentration (X)
Coordinate, trap (Y) are ordinate, draw standard curve.See Fig. 1.
11 standard curve determination data of table
Medicinal extract total starches assay：Accurate measurement sample polysaccharide concentrate 0.20mL, it is same by bioassay standard curve
Its absorbance is surveyed in method operation.
It can sample polyoses content be directly after readout process from standard curve：0.01046mg/mL is calculated and is understood leaching
Polyoses content in cream powder is 51.22%.
It is intended to illustrate invention above, the scope of the present invention is not limited.Those skilled in the art are to the displosure
Scheme on the basis of can carry out improvement and variation without departing from scope and spirit.
Embodiment 6：Therapeutic effect and curative effect
Present inventor passes through a large amount of clinical test and research, the integration of drinking and medicinal herbs Chinese medicine composition of the progestogenic provided
Based on " dredging oviduct, tonifying kidney and benefiting sperm, nourishing qi and blood ", for treating deficiency of spleen and stomach, YANG QI deficiency etc. caused by it is infertile
Disease has good curative effect, and can improve the symptoms such as abdominal pain, irregular menstruation.Below in conjunction with specific embodiment to the present invention into
Row is further described in detail.
Model case：
Case one：Section ××, female is 28 years old, married, the menarche in 17 years old of first visit in 19 days 2 months in 2015, and menstrual period are often wrong
Afterwards, it is dim to measure few color, band was wrapped with paper half and permitted through about 23 days.Premenstrual two breast is made swollen, and few abdomen is ached, the soreness and weakness of waist and knees after, tired nothing
Power.Usually feelings are unsmooth, and chest gastral cavity does not relax, profuse leukorrhea, and sticky raw meat is dirty, 6 years after marriage, still do not breed.Gynecologial examination：It sends out in uterus
Slightly hypsokinesis less than normal, the accessible streak object in left side are educated, and has tenderness, is examined as primary infertility, adnexitis.Examine deep thready pulse, tongue
Light tongue is white.Disease belongs to deficiency of spleen and stomach, YANG QI deficiency, and quasi- warming kidney and strengthening spleen is to control：
Prescription sealwort 20g, Chinese yam 20g, fruit of Chinese wolfberry 18g, raspberry 18g, air bladder 15g, Radix Angelicae Sinensis 3g, peach kernel 6g, Poria cocos
20g, cloves 6g, fennel seeds 6g.6 doses, the next day it is one, be decocted in water for oral dose
12 grams of external application frutus cnidii, 6 grams of Cortex Phellodendri, 3 grams of Wu's cornel, 3 grams of alumen, cloth bag is soaked, hip bath fumigation, 6 doses, twice-daily.
Two examine (March 18)
Become normal in menstrual onset on March 10, period after medicine, amount is more earlier above, through dim at the beginning of color, then turns red, abdomen of breast distenting before menstruation
Pain subtracts, and band was wrapped through four days with paper about one.Now still pain in the back knee is soft, profuse leukorrhea, and the dilute color of matter is light, this deficiency of spleen and stomach, yang-energy is not
Foot controls quasi- tonifying speen and tonifying kidney, warm lower burnt for method：
Prescription sealwort 20g, Chinese yam 20g, fruit of Chinese wolfberry 18g, raspberry 18g, air bladder 15g, Radix Angelicae Sinensis 3g, peach kernel 6g, Poria cocos
20g, cloves 6g, fennel seeds 6g.6 doses, the next day it is one, be decocted in water for oral dose
12 grams of external application frutus cnidii, 6 grams of Cortex Phellodendri, 3 grams of Wu's cornel, 3 grams of alumen, cloth bag is soaked, hip bath fumigation, 6 doses, twice-daily.
Menstruation comes at the appointed time after medication conditioning, colo(u)r specification, after restructuring pill with the meaning of top, improves the several months, be afterwards by
It is pregnant
Case two：Dry XX, female is 29 years old, married, and 4 years unpregnancies, delayed menstrual cycle measure and lack color after marriage at the beginning of 10 days November in 2014
It is light, there is a block, premenstrual two breast is made swollen, and soreness of waist cold and pain in the lower abdomen, generally deficiency of food is just dilute, and clear abundant urine, four limbs are not warm, lower body chilly, body
Tired weak, white discharge capacity is more, and matter is dilute, underbelly, arthralgia, gynecologial examination cervical erosion, palace body anteposition, and fallopian tubal is omited in developing womb
It is unobstructed.It examines as " anovulatory menstruation ", " primary pregnant feelings card belongs to the insufficiency of both the spleen and the kindey, and cold-dampness hinders born of the same parents, and extravasated blood hinders network, controls quasi- tonifying spleen and kidney
Cold dispelling dredging collateral is method：
Prescription sealwort 20g, Chinese yam 20g, fruit of Chinese wolfberry 18g, raspberry 18g, air bladder 15g, Radix Angelicae Sinensis 3g, peach kernel 6g, Poria cocos
20g, cloves 6g, fennel seeds 6g.30 doses, one dose per day.
Two examine (December 10)
Menses this morning comes at the appointed time, and the few color of amount is light red, soreness of waist abdominal pain, defecate dilute, day one, two rows.Become under this menses, edema with the liver involved
It loses and grows, multiply insult board soil, then quasi- tonifying spleen and kidney, nourishing blood for regulating menstruation is method：
Sealwort 25g, Chinese yam 20g, fruit of Chinese wolfberry 18g, raspberry 18g, air bladder 15g, Radix Angelicae Sinensis 6g, peach kernel 6g, Poria cocos 20g, fourth
Fragrant 6g, fennel seeds 6g.It 30 doses, is decocted in water for oral dose, day is one.
Three examine (January 10)
Recently sour abdomen pendant, few abdomen secret anguish, two newborn micro- swollen, pink tongues, qi-regulating menstruation regulating, prescription of making the best use of the situation：Sealwort 25g, mountain
Medicine 20g, fruit of Chinese wolfberry 18g, raspberry 18g, air bladder 15g, Radix Angelicae Sinensis 6g, peach kernel 6g, Poria cocos 20g, cloves 6g, fennel seeds 6g.Conditioning
Several months, when further consultation, five Zhou Weizhi, tastelessness, happiness acid detest oil for menstruation, this is educating eusemia, advises and does pregnant experiment of relieving, and fruit is positive
Property.A baby is given birth to after October, mothers and sons pacify.
Case three：King XX, female is 32 years old, married, 13 first visit July in 2015.It 7 years after marriage, does not breed so far.Generally menstrual period prolong
Afterwards, color is dark in amount, often presss from both sides clot, and premenstrual two breast makees swollen, dizzy nausea, and last menstrual period was on June 24th, 2015.Soreness and weakness of waist and knees,
Distention and pain in the lower abdomen be intended to by, light with lower color, thin tasteful, doctor trained in Western medicine is examined as " primary infertility " " bilateral salpingo adhesion ", thin and delicate by arteries and veins,
Pale tongue, tongue are thin white.Card belongs to deficiency of spleen and stomach, YANG QI deficiency, and extravasated blood hinders network, intends warming kidney and strengthening spleen, promoting blood circulation and removing blood stasis is method：
Prescription sealwort 20g, Chinese yam 20g, fruit of Chinese wolfberry 18g, raspberry 18g, air bladder 15g, Radix Angelicae Sinensis 3g, peach kernel 6g, Poria cocos
20g, cloves 6g, fennel seeds 6g.It 30 doses, is decocted in water for oral dose.
Two examine (August 13 days)
Soreness of waist weak sense mitigates after medicine, has lacked under band.Obtained effect machine, former method more into.It 30 doses, is decocted in water for oral dose.Menstruation is accurate after medicine
Phase and arrive, colo(u)r specification, clot reduce, also have no the diseases such as mammary swelling, abdominal pain before menstruation.Quasi- pill slow-readjustment, daily early, middle and late gradation
Plain boiled water is sent down, and above-mentioned pill is still taken after.Conditioning 10 months, and through gynecologial examination " bilateral salpingo is unobstructed ", it is rear to become pregnant.
Case four：Grandson XX, female is 28 years old, married, three carries at the beginning of 4 days Mays in 2015, never breeds after marriage.Menses the past is such as
Often, after suffering from " 192 adenohypersthenia of first shape " within 2006, that is, there is irregular menstruation, through being treated with Chinese and western drugs, though palpitaition, insomnia,
Hand tremor, spontaneous perspiration, all diseases of dysphoria with smothery sensation alleviate substantially, but menses is not followed still often.Gynecologial examination, meaning developing womb is less than normal, remaining without exception.
Examine that neck is coarse quarter, the thyroid gland of accessible enlargement, when sense suppress Facial flush, the soreness of waist is weak, lower limb chilly, thin, the moon under band
Postmenstruation, the few color of amount is dim, and last menstrual period was March 23, and arteries and veins is thin and delicate, and pale tongue with thin fur is white.This deficiency of spleen and stomach, YANG QI deficiency, extravasated blood
The disease for hindering network gives warming kidney and strengthening spleen, and promoting blood circulation and removing blood stasis is method：
Prescription sealwort 30g, Chinese yam 20g, fruit of Chinese wolfberry 18g, raspberry 18g, air bladder 15g, Radix Angelicae Sinensis 9g, peach kernel 6g, Poria cocos
20g, cloves 6g, fennel seeds 6g.Superfine end is ground in medicine-feeding altogether, and early daily, evening respectively takes 3 grams, and brown sugar mixing in water for oral taking separately uses 12 grams of frutus cnidii,
6 grams of Cortex Phellodendri, 3 grams of Wu's cornel.Cloth bag is soaked, hip bath, twice a day.
Medicine-feeding is continuous altogether to take six material, even served two material and stops one section and renews clothes, and the obvious improvement of food dormancy, soreness and weakness of waist and knees and lower limb chilly are
It is clearly better.Menstruation respectively at January in 2016 8 mesh, rise within 10 days 2 months, colo(u)r specification is fine, before menstruation slightly abdominal pain.It advises and still takes medicine-feeding,
Being changed to the daily morning takes once, and adds that " Babao Kunshun Dan one is paid just before going to bed.Further consultation after half a year has been pregnant 3 months
Case five：Old XX, female is 25 years old, married, first visit on April 5 in 2015.It more than pregnant February, leaks red three days, is protected from clothes
It is more than that tire ball number pays blood.Again plus underbelly secret anguish, back is miserable, two skelasthenias, and urine frequency is short, or from losing, dizzy colourless, four ends
Not warm, the thin string of arteries and veins, tongue is thin white, this kidney qi is weak, is difficult to carry tire, the debility of chong and ren channels, taste virtual loss takes the photograph blood dereliction of duty, it is solid to control quasi- warm kidney
Tire, ridging hemostasis are method：
Prescription：Sealwort 30g, Chinese yam 20g, fruit of Chinese wolfberry 18g, raspberry 18g, air bladder 15g, Radix Angelicae Sinensis 3g Poria cocos 20g, cloves
6g, fennel seeds 6g.It 3 doses, is decocted in water for oral dose.
Two examine (April 10)
Threatened abortion reduction, color turn light, and four ends are gradually warm, and abdominal pain has been stopped, only still the soreness of waist is powerless, and shortness of breath is urinated frequently, and it is thin that arteries and veins carrys out string.Tire
Temporarily pacify though gas obtains, kidney qi must not yet answer, then walk former method, and business is careful tired.
Prescription sealwort 30g, Chinese yam 20g, fruit of Chinese wolfberry 18g, raspberry 18g, air bladder 15g, Radix Angelicae Sinensis 3g, Poria cocos 20g, cloves
6g, fennel seeds 6g.It 5 doses, is decocted in water for oral dose.
Three examine (April 15)
Threatened abortion has been stopped, and urine is as usual, and complexion turns profit, slightly feels the soreness of waist, and arteries and veins delays in sliding, and top comes in and goes out and gives 3 doses again and pacify.
Case six：Seat XX, female is 27 years old, married, the first visit on the 8th of August in 2015.It is pregnant by March, soreness and weakness of waist and knees, lower limb chilly,
Threatened abortion is endlessly.Just only drop and under, yesterday hypervolemia, color is light red, waist backbone acid pendant, clear abundant urine, pale tongue with white fur, and arteries and veins is thin
It is weak.Menstrual period the past postpone, and the light amount of color is few.This deficiency of spleen and stomach, YANG QI deficiency, without doubt.It is method to control suitable warming kidney and strengthening spleen：
Prescription sealwort 25g, Chinese yam 20g, fruit of Chinese wolfberry 18g, raspberry 18g, air bladder 15g, Radix Angelicae Sinensis 6g, Poria cocos 20g, cloves
6g, fennel seeds 6g.It 2 doses, is decocted in water for oral dose.
Two examine (August 10 days)
There is threatened abortion after medicine subtracts, and only soreness of waist abdomen pendant remains unchanged.This blood go it is more, it is lower member lose support, the debility of chong and ren channels, be tire inability, bear
Worry, which is fallen, dies.Preceding method is still walked, and advises and lies up, as a means for the treatment of.
Prescription sealwort 30g, Chinese yam 20g, fruit of Chinese wolfberry 18g, raspberry 18g, air bladder 15g, Radix Angelicae Sinensis 6g, Poria cocos 20g, cloves
3g, fennel seeds 6g.It 3 doses, is decocted in water for oral dose
Three examine (August 14 days)
Leak down still to have that drop is not net, soreness of waist abdomen pendant subtracts and do not remove.Though obtaining effect machine, must still rest, Strengthen kidney for fetus soothing, just like preceding
Method：
Prescription sealwort 20g, Chinese yam 20g, fruit of Chinese wolfberry 18g, raspberry 18g, air bladder 15g, Radix Angelicae Sinensis 6g, Poria cocos 20g, fennel seeds
6g.Two doses.
The four methods of diagnosis (August 17 days)
Threatened abortion has been stopped after medicine, slightly feels the soreness of waist, if remaining disease is lost, top takes 3 doses, rests a few days again, must answer then often.Natural labor one afterwards
Son, nothing else are abnormal.
Case seven：King XX, female is 29 years old, married, the first visit on the 13rd of September in 2016.Constitution element is weak, intolerant to tired, receives rear gastral cavity abdomen
Support it is swollen, it is common dizzy, four end it is chilly, two it is pregnant all die, pregnant this time by April, endlessly, the light matter of color is dilute for threatened abortion, abdomen fall do not relax,
Back is aching and limp, and two skelasthenias, complexion is with regard to white, pale tongue with white fur, deep thready pulse string.This is spleen kidney qi deficiency, and powerless Wen Yun has dereliction of duty under one's command,
Liability to be abortion, need the solid member of QI invigorating, preferably prevent following the track of the overturned cart.
Prescription sealwort 25g, Chinese yam 20g, fruit of Chinese wolfberry 18g, raspberry 18g, air bladder 15g, Radix Angelicae Sinensis 3g, Poria cocos 20g, cloves
6g, fennel seeds 6g.It 3 doses, is decocted in water for oral dose.
Two examine (September 17 days)
The red reduction of medicine back leak, tire pendant is relatively slow, and the soreness of waist is gradually light, and arteries and veins is still thin and delicate, in front of following the service：
Prescription sealwort 30g, Chinese yam 20g, fruit of Chinese wolfberry 18g, raspberry 18g, air bladder 15g, Radix Angelicae Sinensis 6g, Poria cocos 20g, cloves
6g, fennel seeds 6g.It 3 doses, is decocted in water for oral dose.
Three examine (September 21 days)
Threatened abortion has been stopped, and four ends turn temperature, if abdomen pendant loses, micro- sense soreness of waist.Temporarily pacify though nausea obtains, still needs to consolidate curative effect, top is gone
Cloves, the unsuitable long term usage of object of fragrant string：
Prescription sealwort 30g, Chinese yam 25g, fruit of Chinese wolfberry 18g, raspberry 18g, air bladder 15g, Radix Angelicae Sinensis 6g, Poria cocos 20g, fennel seeds
6g.It 4 doses, is decocted in water for oral dose.
It again with top after hereby, advises and monthly takes three doses, until eight months are discontinued.Appointed date lifts a baby, and mothers and sons are in good health.
Case eight：Zhao XX, female is 28 years old, married, and first visit on July 30 in 2015 2 years after marriage, three pregnant three die, last abortion
The January before 1 year.Menses is uncomfortable after hereby, delayed menstrual cycle, and the few color of amount is shallow, and menalgia once gives blood-nourishing and blood, improves the several months,
Last menstrual period exceeded the time limit not go for eight days June 23.Gynecologial examination, uterine neck is gently rotten, and palace body is without significantly increasing, with dizziness
The soreness of waist, Na Gu is fragrant, spiritlessness and weakness, and underbelly is micro- swollen, and lower limb chilly, pulse condition is thin and delicate, pale tongue with thin fur.This is deficiency of spleen and stomach, yang-energy
Deficiency intends tonifying spleen and kidney, nourishing qi and blood.Consider its pregnancy, after advising the stop over 15th day of a month, remakes gynaecological examination.
Prescription sealwort 20g, Chinese yam 20g, fruit of Chinese wolfberry 18g, raspberry 18g, air bladder 15g, Radix Angelicae Sinensis 3g, Poria cocos 20g, cloves
3g, fennel seeds 6g.It 4 doses, is decocted in water for oral dose.It such as has no adverse reaction after medication, can continue and take 4 doses, withdrawal observation.
Two examine (October 2)
Further consultation gestation more than March, waist backbone is miserable, and limb is soft weak, underbelly pendant sense, chest gastral cavity ruffian, mouth is light, occasionally have it is general ripple, arteries and veins
Thin and delicate, tongue moistens that tongue is thin, and card belongs to speen-kidney dificiency, qi-blood disharmony, considers its knot and unreal, follows the track of the overturned cart, urgently with warming kidney and strengthening spleen, QI invigorating is supported
Blood is method：
Prescription sealwort 20g, Chinese yam 20g, fruit of Chinese wolfberry 18g, raspberry 18g, air bladder 15g, Radix Angelicae Sinensis 3g, Poria cocos 20g, cloves
3g, fennel seeds 6g.It 4 doses, is decocted in water for oral dose.
Three examine (October 15)
Front takes eight doses altogether, and soreness of waist back of the body Chu mitigates earlier above, and it is soft also light that abdomen falls limb.Casual offense is cold and cool a few days ago, and body Chu is uncomfortable, ripples
It is intended to vomit, leg or cramp, the thin slippery of tongue, top adds with ginger preventing or arresting vomiting：
Prescription sealwort 20g, Chinese yam 20g, fruit of Chinese wolfberry 18g, raspberry 18g, air bladder 15g, Radix Angelicae Sinensis 3g, Poria cocos 20g, cloves
3g, fennel seeds 6g, ginger 6g.It 4 doses, is decocted in water for oral dose.
The four methods of diagnosis (December 16)
Pregnant by June, the soreness of waist subtracts greatly, and abdomen pendant has removed, receive can sleep can, tongue is thin white, and arteries and veins is thin and delicate.Though nausea is pacified, the gas of spleen kidney
It is not multiple, then walk former method：
Prescription sealwort 20g, Chinese yam 20g, fruit of Chinese wolfberry 18g, raspberry 18g, air bladder 15g, Radix Angelicae Sinensis 3g, Poria cocos 20g, cloves
3g, fennel seeds 6g, ginger 3g.4 doses, be decocted in water for oral dose.
Five examine (on 2 21st, 2016)
It is pregnant by August, action slightly feels weak, and remaining without special discomfort, slippery is even, and tongue nature is light red, and tongue is thin.It advises and does not take medicine, it is careful cold
Temperature fits work and rest, and prohibition of life is cold, and taking good care of oneself can.Then mature and produce after, mother and daughter is healthy.
Claims (11)
1. a kind of integration of drinking and medicinal herbs Chinese medicine composition of progestogenic, which is characterized in that bulk pharmaceutical chemicals are：10~30 parts of sealwort, Chinese yam 10~
30 parts, 9~27 parts of the fruit of Chinese wolfberry, 9~27 parts of raspberry, 10~20 parts of air bladder, 2~5 parts of Radix Angelicae Sinensis, 3~9 parts of peach kernel, Poria cocos 10~
30 parts, 3~9 parts of cloves, 3~9 parts of fennel seeds；Described part is parts by weight.
2. according to a kind of integration of drinking and medicinal herbs Chinese medicine composition of progestogenic described in claim 1, which is characterized in that the weight of each bulk pharmaceutical chemicals
Part it is：20 parts of sealwort, 20 parts of Chinese yam, 18 parts of the fruit of Chinese wolfberry, 18 parts of raspberry, 15 parts of air bladder, 3 parts of Radix Angelicae Sinensis, 6 parts of peach kernel, Poria cocos 20
Part, 6 parts of cloves, 6 parts of fennel seeds.
3. according to any Chinese medicine compositions of claim 1-2, it is characterised in that：It is made and appoints according to Chinese medicine conventional formulation method
A kind of what clinically suitable preparation.
4. according to the Chinese medicine composition described in claim 1-2, it is characterised in that：
(1) the Key Quality attribute of the integration of drinking and medicinal herbs Chinese medicine composition is determined；
(2) qaudrature-homogeneous design is used to confirm key process parameter；
(3) index of correlation in extractive technique is measured, ensures the stabilization of preparation process；
(4) preparation method for determining said preparation is established according to (3)；
(5) evaluation method of said preparation is established according to (4).
5. Chinese medicine composition according to claim 1 or 2, it is characterised in that：Technology assessment index is paste-forming rate.
6. according to the Chinese medicine composition described in one of claim 1-2, it is characterised in that：Technology assessment index is paste-forming rate, molten
The property changed, dry extract total starches content.
7. a kind of preparation method of the Chinese medicine composition described in claim 1-2, it is characterised in that：
Extraction time 1-3 times, extraction time 1-2 hour, extraction water measure 6-10 times again.
8. according to a kind of integration of drinking and medicinal herbs Traditional Chinese medicine composition formula particle of progestogenic of claim 1-2, it is characterised in that：
(1) prepare each bulk pharmaceutical chemicals according to the parts by weight；
(2) it takes (1) raw material to add 6-10 times of water, extracts 1-2 hours, extract 1-3 times, merge extracting solution；
(3) (2) extracting solution is taken, the medicinal extract of relative density 1.20-1.25 is measured when being concentrated into 25 DEG C, obtains extraction medicinal extract；
(4) (3) medicinal extract is taken, drying, 60 DEG C of drying temperature, pressure 0.08-0.09MPa in vacuum drying chamber is set and obtains dry extract, it will
Dry extract crushed 80 mesh sieve, obtain extract powder；
(5) (4) extract powder is mixed with auxiliary material, using wet granulation, corrigent, adhesive is added；Medicinal material dry extract：Filling
Agent=1:1.35, corrigent 1-2 ‰, mixing, described part are parts by weight；Softwood processed is pelletized, and dry, whole grain is to get particle
Agent.
9. preparation method according to claim 7, it is characterised in that：
Extraction time 3 times, 1 hour extraction time, extraction water measure 6 times again.
10. preparation method according to claim 7, which is characterized in that filler is dextrin, and adhesive is 90% ethyl alcohol,
Corrigent is Sucralose.
11. Chinese medicine composition described in one of claim 1-2 is prepared by the preparation method of one of claim 7-9
Purposes of the Chinese medicine composition in the integration of drinking and medicinal herbs Chinese medicine composition for preparing progestogenic.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110093237A (en) * | 2019-04-30 | 2019-08-06 | 北京御骐医学研究有限责任公司 | A kind of integration of drinking and medicinal herbs is tonified Qi of the kidney edible wine and its preparation process |
| CN114323137B (en) * | 2021-12-28 | 2023-06-20 | 湖南新汇制药股份有限公司 | Quality detection method for steamed rhizoma polygonati standard decoction |
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| KR20120064247A (en) * | 2010-12-09 | 2012-06-19 | 이종훈 | Supplement for pregnancy |
| CN107343924A (en) * | 2016-05-04 | 2017-11-14 | 王停 | A kind of Chinese medicinal formulae for the pregnant pre-conditioning of women |
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2018
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| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20120064247A (en) * | 2010-12-09 | 2012-06-19 | 이종훈 | Supplement for pregnancy |
| CN107343924A (en) * | 2016-05-04 | 2017-11-14 | 王停 | A kind of Chinese medicinal formulae for the pregnant pre-conditioning of women |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110093237A (en) * | 2019-04-30 | 2019-08-06 | 北京御骐医学研究有限责任公司 | A kind of integration of drinking and medicinal herbs is tonified Qi of the kidney edible wine and its preparation process |
| CN114323137B (en) * | 2021-12-28 | 2023-06-20 | 湖南新汇制药股份有限公司 | Quality detection method for steamed rhizoma polygonati standard decoction |
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