CN107242563A - A kind of fatigue resistant health food and preparation method thereof - Google Patents
A kind of fatigue resistant health food and preparation method thereof Download PDFInfo
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- CN107242563A CN107242563A CN201710253691.XA CN201710253691A CN107242563A CN 107242563 A CN107242563 A CN 107242563A CN 201710253691 A CN201710253691 A CN 201710253691A CN 107242563 A CN107242563 A CN 107242563A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a kind of fatigue resistant health food and preparation method thereof, by maca, ginseng, gumbo extract, sealwort, ginkgo biloba extract, tribulus terrestris extraction, cinnamomum cassia extract, citrulling, L arginine.It is made by pulverizing and sieving → premixing → pelletizing drying → whole grain → total mixed → tabletting → coating → inner packing → outsourcing → storage.Safety of the invention, non-toxic, orally available, oral or instant, the healthcare function for the sleep that is significantly improved.
Description
Technical field
The invention belongs to field of health care products, specifically, it is related to a kind of fatigue resistant health food and preparation method thereof.
Background technology
Tired (fatigue) is a comprehensive physiology course for being related to many Physiology and biochemistry factors, is that human body is mental
Or physical exertion to certain phase when a kind of normal physiological phenomenon for necessarily occurring, it had both indicated the original ability to work of body
Temporary transient decline, be probably the tendency that body develops into sick and wounded state again.People once descended to be permitted when studying fatigue to it
Many definition, nineteen eighty-two, in the biochemical academic conference of the 5th international movement, fatigue was defined as：Organism physiology process can not continue
On the specified level of its function and/or it can not maintain predetermined exercise intensity.
Fatigue is a kind of subjective sense of discomfort, is mainly shown as sense of fatigue, taediumvitae, in progress long-time work, acutely
It can be perceived under motion or long-time stress, this is a kind of normal physiological protection reaction, points out body to pass through
Rest makes functional recovery, so as to avoid the further injury to body.However as the aggravation of social competition, rhythm of life plus
It hurry up, people is usually ignored fatigue, still selection works long hours.Fatigue state is chronically at, can insulting muscle power, body
Can, body is unbalance, makes one to be difficult to be engaged in or complete some larger or fine and smooth, exquisite work of action that consume one's strength, so that work
Make efficiency decline；On the other hand, chronic fatigue can also make one cutis laxa, and lusterless complexion shows prematurely senile sign；It is long
Phase fatigue cannot be recovered, and make human body immune system dysfunction, or even cause immunocompromised, the barrier of body resist the disease
It is broken, making the probability of patient increases.In addition, long-term psychological pressure, hormone disturbance, dysimmunity etc., are to cause slow
The main inducing of fatigue syndrome.The working of excess load, excessive pressure makes people usually feel with irregular daily life system
Feel that sense of fatigue, taediumvitae are difficult to recover for a long time, people is chronically at the people that there are about 70% in sub-health state, crowd
In this state, wherein again occurred frequently with the elderly.
Substantial amounts of result of study confirms that fatigue is likely to occur in such a wide from cerebral cortex to muscle subcellular structure
General region.Edwards in 1980 proposes any one link in the concept of " neuro-muscular fatigue chain ", chain and destroyed
Or have interruption, it can all cause muscle strength to decline and power output reduction.According to the position that fatigue occurs in tired chain, Ke Yifen
For central nerve fatigue and the tired two large divisions of external application.Central nerve fatigue refers to from cerebral cortex → spinal cord → this section of nervus peripheralis region hair
Raw fatigue；Peripheral fatigue refers to the fatigue that the following link of neuro-muscular contact occurs.
Based on this, it is necessary to find antifatigue material to delay to make under work, strenuous exercise or excessive stress for a long time
Into fatigue occur, or fatigue state is returned to normal condition as early as possible, to make people's sub-health state recover normal or right
Fatigue syndrome produces curative effect.Existing fatigue resistant health food is main based on Chinese medicine, and feature is to focus on health, and consumer needs
Long-term taking, works slow.
Therefore it provides a kind of new anti-fatigue product has realistic meaning.
The content of the invention
To solve above technical problem, an object of the present invention is to provide a kind of antifatigue, correction sub-health state
Health products.
The second object of the present invention is to provide a kind of health products preparation method that is antifatigue, correcting sub-health state.
What one of the object of the invention was realized in：
A kind of fatigue resistant health food, by weight comprising following components：
Above-mentioned health food is also added with pharmaceutic adjuvant.
Above-mentioned health food is oral liquid, beverage, tablet, capsule, spray or cutaneous permeable agent.This health food is given
Prescription formula is oral or external application.The mode of taking of described health food is daily 1~2 time, each 100-2000mg/kg bodies
Weight.
What the two of the object of the invention were realized in：
A kind of preparation method of fatigue resistant health food, is carried out as follows：Supplementary material pulverizes and sieves, and → premix → makes
Grain drying → whole grain → total mixed → tabletting → coating → inner packing → outsourcing → storage.
This health food is applied to correct sub-health state or treatment chronic fatigue syndrome；The correction inferior health
State is increase hepatic glycogen content, reduces full blood lactic content or reduction Plasma Urea nitrogen content.
It is the main component of this health products below.
L-arginine (Arginine)
Arginine be a kind of amino acid containing two basic groups and amino and guanidine radicals under physiological ph conditions, belong to alkali
Acidic amino acid (PH 10.5~12.0), molecular formula is C6H14N4O2, molecular weight 174.20, fusing point:223~224 DEG C, white water chestnut
Shape crystallization (being separated out from water, containing 2 molecular crystalline water) or monocline flaky crystal (nodeless mesh water), odorless, bitter；Soluble in water (0
Solubility is that solubility is 400g/L in 83g/L, 50 DEG C of water in DEG C water), it is atomic to be dissolved in ethanol, insoluble in ether in nature
In with the presence of two kinds of isomers:Have important nutrition physiology effect in D-Arg and L-arginine, animal body is L- essences
Propylhomoserin
L-arginine is the important source material of synthetic protein and creatine, is the smart ammonia of semi-dispensable amino acid in humans and animals body
Acid has important physiology, metabolism and trophism, and almost institute utilizes Arg synthetic cells slurry albumen and core in a organized way in body
Albumen arginine is promoting the synthesis of muscle internal protein, strengthens the immunity of body, cell division, wound restores and secretion swashs
In the various physiology courses such as element, the premise material that important role's arginine is also internal synthesis NO is also all served as, and it is internal
The increase of NO synthesis, for balance blood, strengthens blood flow, improves cardiac and cerebral blood-supply, strengthen blood vessel elasticity, recover vascular function effect
Substantially.It is most strong vascular relaxing factor, with the function of resisting athero- artery sclerosis, adjust blood pressure, arginic a variety of biologies
The extensive concern that function causes nutrition and Medical Research Work person is learned, so that one of focus studied as current amino acid
Citrulling
Contain an important beneficiating ingredient in latest find watermelon ----citrulling.Amino acid is the base for constituting protein
Our unit, citrulling is one kind of amino acid.The content of citrulling is all higher than any food in watermelon, and people are from watermelon earliest
Thus middle extraction citrulling, citrulling gains the name.
Citrulling is to be generated from ornithine and carbamyl phosphate in urea cycle, or passes through nitricoxide synthase
(NOS) catalysis arginine generates NO accessory substance.First, arginine can be oxidized to N- hydroxyls-arginine, then row is oxidized to melon
Propylhomoserin simultaneously disengages nitric oxide.
Appropriate citrulling and various vitamins can promote to increase energy, and maintain immune system.Citrulling helps body
Body sets up and pressure, can also maintain body ph balancing.
Improve the motor function in Jiankang, citrulling can be acted on ammonia in human body, generation arginine and nitric oxide.One oxygen
Change nitrogen energy activating enzyme, cause smooth muscle relaxation.It can also make the blood vessel of people be relaxed, and for strengthening function, contribute to
Reproductive function.
Ginseng (Panax ginseng)
Ginseng, also known as Asia are joined, and are the roots with meat at Northeast China popular name " wooden club ", pharmaceutically acceptable.Ginseng belongs to
Araliaceae, is mainly grown in East Asia, particularly cold district.Ginseng is the common medicinal material in Asia, and northern Central America is also generally using flower
Flag is joined.
Why very rare ginseng is, very rare, mainly relevant with its medical value.In medical book very early《Legendary god of farming's book on Chinese herbal medicine
Through》In be considered as, ginseng has functions that " tonifying five zang organs, soothe the nerves, determine soul, stop palpitate with fear, remove pathogenic factor, happy intelligence development tomorrow ", " long
Take macrobiosis of making light of one's life by commiting suicide ".Li Shizhen (1518-1593 A.D.) exists《Compendium of Materia Medica》In also ginseng is extremely praised highly, it is believed that it can " control male woman all chronic diseases marked by deficiency of vital energy ".
Ginseng can isolate more than 30 and plant panaxoside, in addition, ginseng is also containing a variety of organic acids and esters, the life of various dimensions
Element, sterol, enzyme and 20 various trace elements.
In daily life, ginseng and its preparation are frequently utilized for more afterwards recovering, strengthen muscle power, regulation hormone, reduction blood glucose
With control blood pressure, control liver index and liver function health care etc..
Ginkgo (Ginkgo biloba L.)
Ginkgo is a kind of plant with very high medical value, and ginkgo is the ancient seeds of China, and it is magical doctor
The tree for the treatment of, pre-Jurassic dinosaur controls terrestrial time within more than 200,000,000 5 thousand years, and ginkgo has been one of most flouring plant.Life on earth is gone through
Through the variation of 100000000000 years, after the glacier covering of especially the 4th century, only ginkgo still kept the looks of its most original, in biology
It is referred to as in evolutionism history " living fossil ".Its leaf, fruit, seed have higher medical value, and its pharmacological action is constantly recognized
Know, clinical application range progressively expands.
The China in Recent Years academy of sciences and lot of domestic and foreign medical expert research are found：Kind more than 160 is can extract in ginkgo leaf to be had
The medicinal ingredient of effect wherein, 35 kinds of flavone compound；17 kinds of amino acid and various trace elements
Ginkgo has anti-aging, improves immunity of organisms, strengthens a variety of functions such as resistance of human body.
Chinese cassia tree (Cortex Cinnamomi Cassiae)
Chinese cassia tree is the dry hide and branch skin in canella Chinese cassia tree and great Ye Qinghua osmanthus.Chinese cassia tree aiphyllium, is born in evergreen broad-leaved
Lin Zhong, but be generally to cultivate.There is cultivation the torrid zone on the ground such as China Fujian, Taiwan, Guangdong, Guangxi, Yunnan and subtropical zone, especially
It is many using Guangxi cultivation, is mostly Artificial Pure.
Effect of Chinese cassia tree and effect, Chinese cassia tree acrid-sweet flavor, property heat, enter kidney, spleen, bladder warp；There are complement sun, warming spleen and stomach, except product
It is cold, effect of coronary circulation-promoting pain-relieving and antidiarrheal；Cure mainly the Yang-function insufficiency of kidneyzang, cold weak pulse of limb, yang depletion collapse, stomachache diarrhea, cold hernia, waist and knee cold
Bitterly, the disease such as cloudy subcutaneous ulcer streamer, empty floating heat in the upper and cold in the lower more of sun.
Sealwort (Polygonatum sibiricum Delar.ex Redonte)
Sealwort is the rhizome of liliaceous plant sealwort, David's-harp and P. kingianum, belongs to help quasi-tradition anti-aging guarantor
Health food.This product is sweet mild-natured nontoxic, and return lung spleen kidney three is passed through, function nourishing Yin and moistening lung, invigorate the spleen and benefit qi, Zishen fill fine.
Sealwort contains a variety of steroidal soaps, Siberian solomonseal rhizome polysaccharide, digitalose and a small amount of green onion Syria class compounds etc., with extension man
Silkworm life cycle, confrontation radical damage, enhancing immunologic function, regulation second messenger's cycli phosphate gland (cAMP) level, enhancing cardiac muscle
Convergent force, enhancing coronary blood flow, hypoglycemic, reducing blood lipid, antibacterial, antiviral, anti-width are penetrated, anti-mutation, antifatigue etc. made
With.It is a kind of Chinese medicine for having a fine DEVELOPMENT PROSPECT.
Tribulus terrestris (Tribulus terrestris L.)
For the fruit of zygophyllaceae 1 year or herbaceos perennial puncture vine, the ground such as northeast, North China and northwest are mainly originated in.
The fatty oil of tribulus terrestris, volatile oil, tannin, resin, sterol, sylvite, Alkaloid, saponin etc..Its water extract, ethanol are leached
Liquid has antihypertensive effect to anesthetized animal；The thick saponin of puncture vine cauline leaf is stimulated by high temperature, low temperature, anoxic and Suppressor cells mouse
There is obvious protective function：And significant vitamin C (Vc) content in adult rat adrenal tissue can be reduced, can also suppress heavy dose of hydrogenation can
Pine caused by exhaust phenomenon, to caused by ACTH Vc contents decline shield.Cut off after mouse bilateral adrenal glands,
Its resisting oxygen lack no longer reappears.These effects may be relevant with adrenal cortex, and it is probably real to adjust its function and exempt from exhaustion
One of existing strong approach.Tribesta (preparation that puncture vine aerial part is made) gives male rat orally can obvious stimulation essence
Son is formed, excited Sai Tuoli cells (Sertolicell) activity, increases sexual desire；Heat can then be promoted by giving female rats, be improved
Fecundity.
Gumbo (Hibiscus esculentus L.)
The alias of gumbo has Abelmoschus esculentus, okra, Radix Solani ferocis etc..Africa is originated in, early 20th century China is introduced by India.
Its edible portion is Fruit pod, tender and crisp succulence, lubricious oiliness, and fragrance is unique, deep to be favored by people.
Containing a kind of stickiness liquid matter and araban, galactan, rhamnosan, protein etc. in gumbo okra fruit, warp
Often to eat with helping digest, strengthen muscle power, protection liver, the whole intestines of stomach invigorating.Gumbo contains the multiple nutritional components such as iron, calcium and carbohydrate,
There is the effect of prevention anaemia.Gumbo contains vitamin A and β-carrotene etc., is beneficial to retinal health, safeguards eyesight；Wherein
Rich in having zinc and selenium and other trace elements, human body anti-cancer, anticancer can be strengthened.Mucin in gumbo plays the role of to suppress sugar absorption,
So in recent years again as the folk prescription for the treatment of diabetes.Gumbo also contains the special medicative composition of tool, and the strong kidney qi-restoratives of energy is right
Male's organic disease has auxiliary therapeutic action, enjoys the good reputation of " plant vigour ".
Maca (Maca)
Maca (Lepidium meyemii Walp), is that Cruciferae separate row Vegetable spp is annual or biennial herbaceous plant,
Originate in the andes region of more than height above sea level 4000m in the middle part of Peru., can be in severe ecological condition because Maca is low temperature resistant, strong wind
Lower growth, as one of local chief crop.Main Leaf-feeding insects are root, storage root 2~5cm of diameter that underground is expanded, surface
Color is mostly yellow or purple, and meat is white or faint yellow, with penetrating odor and special butterscotch smell.
At present, the high place of production (based on cultivation product) of maca is still in Andes Ka Huama fertile lands area (Carhuamayo) and Hu Ningqu
(Junin).The out of condition of the ground such as other regional or external Germany, Czech is introduced a fine variety to Peru, and depauperation does not obtain satisfied
As a result.It is the high and cold of 4000~4500m of height above sea level, high wind and high Rizhao Area maca suitable growth.
Maca (Maca) is the plant of dietotherapeutic, and special product is used as in South America Peru, local Inca, tonic,
It is called Peru's ginseng.The ground such as Peru in South America, can be fried during maca root using fresh herb together with meat or other vegetables it is edible, after drying
I.e. edible then is cooked with water or milk, for thousands of years, maca root is used to strengthen energy as food and herbal medicine, antifatigue, changes
Kind sexual function, improves fertility, treatment female climacteric syndrome etc..
Experiment
Swimming with a load attached to the body is the important indicator for evaluating body movement fatigue, and the length of swimming time can reflect animal movement
The degree of fatigue.The glycogen of cylinder storage is the main energy sources of mouse movement, and body strenuous exercise needs to consume a large amount of sugar
Original, therefore glycogen deposit is also an important indicator for evaluating body fatigue resistance.Lactic acid occupies important in body energy supply system
Status, it be glycolysis energy supply final product, be the important oxygen metabolism matrix in aerobic metabolism energy supplying system again, and breast
Acid can in liver by sugar heteroplasia role transformation for glucose energy supply.But if excessive lactic acid meetings are produced in body
H+ concentration in muscle is risen .pH declines, and then cause a series of Biochemical changes, fatigue will be caused.Studies have shown that urea nitrogen
(BUN) increase is negatively correlated to load performance with body, and body BUN contents increase with the increase of exercise load, institute
It is ideal, sensitive fatigue index with BUN.
1 materials and methods
1.1 sample：
1.2 experimental animal：Middle age at five monthly ages male ICR mouse；Age in August Old Male C57 mouse.
1.3 instruments and reagent：Swimming trunk, galvanized wire, all-wave length ELIASA, constant water bath box, centrifuge, hepatic glycogen detection examination
Agent box (Nanjing is built up, article No. A043), lactate acid detection kit (Nanjing is built up, article No. A019-1), urea nitrogen kit (Nanjing
Build up, article No. C013-1).
1.4 experimental method：
A. first：The 60 middle age monthly age of male five ICR mouse are randomly divided into 4 groups, every group 15.Small dose group abdominal cavity
Drug administration by injection 400mg/kg medicine, middle dosage intraperitoneal injection 800mg/kg medicine, heavy dose of intraperitoneal injection
1600mg/kg medicine.Control group group gives the physiological saline of same volume.In every morning 10:00 to 11:00 is administered once,
Successive administration 7 days.
B. second batch：100 male old age age in August C57 mouse are randomly divided into 4 groups, every group 20.Small dose group is filled
Stomach 400mg/kg medicine, middle dosage gavage 800mg/kg medicine, heavy dose fills 1600mg/kg medicine.Control group is given
The water of same volume.In every morning 10:00 to 11:00 is administered once, successive administration 7 days.
C. the 3rd batch：The 80 middle age monthly age of male five ICR mouse are randomly divided into 4 groups, every group 20.The normal ring of control group
Raised 14 days under border, its excess-three group carries out chronic fatigue syndrome modeling：Every morning 9:00 to 11:00 is fettered, every time
One hour, mouse was put into the depth of water for 35cm by every afternoon, and water temperature is forces swimming 1 hour in 21 ± 1 DEG C of swimming trunk, continuously
Modeling 14 days.It was administered since the 15th day, low dose of gavage 400mg/kg medicine, heavy dose of gavage 1600mg/kg medicine.
Control group group gives the water of same volume.In every morning 10:00 to 11:00 is administered once, successive administration 7 days.
1.4.1 swimming with a load attached to the body is tested
Last is given after health food 30min, and the galvanized wire of 4% mass of its body weight is born to mouse tail.Mouse is put into
The depth of water is 35cm, and water temperature is swims in 21 ± 1 DEG C of swimming trunk, until power exhausts.The criterion that power exhausts is sunk to for mouse head
Do not emerged in 10s in water, record power exhausts the time.
1.4.2 hepatic glycogen is determined
After mice burden swimming, rest 10 minutes, put to death mouse after eyeball blood sampling is plucked.Liver is taken out, physiology salt is used
Blotted again with filter paper after water rinsing, accurately weigh 50mg livers.The measure of liver hepatic glycogen is carried out according to kit specification.
1.4.3 full blood lactic is determined
After mice burden swimming, rest 10 minutes, extract eyeball and take blood, the survey for carrying out full blood lactic is illustrated according to kit
It is fixed.
1.4.4 blood plasma index determining
After mice burden swimming, rest 10 minutes, eyeball blood sampling, after leaving the heart 10 minutes with after EDETATE SODIUM salt anti-freezing 3500
Blood plasma is isolated, the measure of plasma urea nitrogen is carried out according to kit specification.
2 results
2.1 mice burden swimming timings
Figure 1A, Figure 1B, Fig. 1 C represent influence of the fatigue resistant health food to the mice burden swimming time.Wherein Figure 1A is the
A collection of intraperitoneal injection experimental result；Figure 1B is the oral experimental result of second batch, and * represents p<0.05.Compared with control group, C is
Three batches of oral treating chronic effort syndrome experimental results.It can be seen from Figure 1A intraperitoneal injection give this health food have prolong
The trend of long mice burden swimming time, and this trend is in dose dependent；It can be seen from Figure 1B compared with control group, mouth
Clothes give after this health food the mice burden swimming time and are presented dose dependent extension, Analysis of variance, in, heavy dose of group with
Control group, which is compared, significant difference (p<0.05).It can be seen from Fig. 1 C compared with control group, the mouse of model group bears a heavy burden
Swimming time is decreased obviously, and orally giving the mice burden swimming time after this health food has compared with model group and substantially prolong
It is long.
2.2 mouse hepatic glycogen are determined
Fig. 2A, Fig. 2 B, Fig. 2 C, represent influence of the fatigue resistant health food to mouse liver glycogen reserves, wherein Fig. 2A is the
A collection of intraperitoneal injection experimental result, * represents p<0.05, compared with control group；Fig. 2 B are the oral experimental result of second batch, and * represents p
<0.05, compared with control group；Fig. 2 C are the 3rd batch of oral treating chronic effort syndrome experimental result, and * represents p<0.05, it is and right
Compare according to group.As seen from Figure 2, compared with control group, whether inject or orally give this health food, mouse glycogen
Former content is dramatically increased, wherein, drug administration by injection is small, neutralize heavy dose of group reaches significance (Fig. 2A) with control group difference,
It is administered orally to neutralize heavy dose and organize and reaches the level of signifiance with control group difference, with statistical significance (p<0.05) (Fig. 2 B), anti-
In chronic fatigue syndrome model experiment, small and middle dose group is administered orally and reaches the level of signifiance (Fig. 2 C), tool with model group difference
Statistically significant (p<0.05).
2.3 Mouse whole blood Plasma lactates
Fig. 3 A, Fig. 3 B, Fig. 3 C represent influence of the fatigue resistant health food to Mouse whole blood lactate level.Wherein Fig. 3 A are the
A collection of intraperitoneal injection experimental result, * represents p<0.05, compared with control group；Fig. 3 B are the oral experimental result of second batch, and C is the
Three batches of oral treating chronic effort syndrome experimental results, * * represent p<0.01, compared with control group.Noted it can be seen from Fig. 3 A
Penetrate and give after this health food, compared with control group, full blood lactic content is decreased obviously, it is the most notable with middle dosage and heavy dose
(p<0.05)；It can be seen from Fig. 3 B compared with control group, orally give after this health food full blood lactic content under
Drop, but only heavy dose of group tool statistical significance (p<0.05).It can be seen from Fig. 3 C compared with model group, this guarantor is orally given
Heavy dose of group Mouse whole blood lactic acid content is obviously prolonged after health food, there is statistically significant meaning (p<0.01).
2.4 mice plasma urea nitrogen contents are determined
The influence of Fig. 4 A, Fig. 4 B, Fig. 4 C, expression fatigue resistant health food to mice plasma urea nitrogen levels.Wherein Fig. 4 A
For first intraperitoneal injection experimental result, * represents p<0.05, compared with control group group；Fig. 4 B are that second batch orally tests knot
Really, * represents p<0.05, compared with control group group；Fig. 4 C are the 3rd batch of oral treating chronic effort syndrome experimental result.By Fig. 4
Decline as can be seen that each dosage group Plasma Urea nitrogen content of this health food is compared compared with control group.Analysis of variance is noted
Penetrate in administration (Fig. 4 A), heavy dose of group has highly significant with control group, (Fig. 4 B) heavy dose group is administered orally to be had with control group
Highly significant (p<0.05) the heavy dose of group for the treatment of chronic effort syndrome (Fig. 4 C), is administered orally has decline to become compared with model group
Gesture, statistically significant (p<0.05).
Experiment shows, when this fatigue resistant health food that the present invention is given in intraperitoneal injection has extension mice burden swimming
Between trend, and this trend be in dose dependent (Figure 1A)；Compared with control group, antifatigue guarantor of the present invention is orally given
Dose dependent extension, Analysis of variance, each dosage group and control group is presented in the mice burden swimming time after health food mixed liquor
Compared to there is significant difference (p<0.05) (Figure 1B).Compared with control group, the mice burden swimming time of model group is decreased obviously,
And orally give the mice burden swimming time after the fatigue resistant health food and be obviously prolonged compared with model group (Fig. 1 C).
Compared with control group, whether inject or orally give fatigue resistant health food, mouse hepatic glycogen content shows
Increase is write, wherein, drug administration by injection is small, neutralize heavy dose of group reaches significance (Fig. 2A) with control group difference, in oral administration,
Heavy dose group reaches the level of signifiance (Fig. 2 B) with control group difference, with statistical significance (p<0.05), integrated in treating chronic effort
In disease model experiment, large and small dosage group is administered orally and reaches the level of signifiance (Fig. 2 C) with model group difference, with statistical significance (p
<0.05)。
Injection is given after fatigue resistant health food, is compared with control group, full blood lactic content is decreased obviously, with middle dosage and
Heavy dose of significantly (p<0.05) (Fig. 3 A)；Compared with control group, orally give full blood lactic after fatigue resistant health food and contain
Amount has declined, but only heavy dose of statistically significant (p of group<0.05) (Fig. 3 B).Compared with model group, orally give anti-
Mouse whole blood lactic acid content is obviously prolonged after tired health food, there is statistically significant meaning (p<0.01) (Fig. 3 C).
Each dosage group Plasma Urea nitrogen content of fatigue resistant health food of the present invention is compared compared with control group have been declined.Through
In variance analysis drug administration by injection, heavy dose is organized and control group has highly significant (p<0.05) (Fig. 4 A), is administered orally heavy dose of
Under group has highly significant, the heavy dose of group of oral administration treating chronic effort syndrome (Fig. 4 C) to have compared with model group with control group
Drop trend, statistically significant (p<0.05) (Fig. 4 C).
Summary experimental result, this fatigue resistant health food that the present invention is provided can be obviously prolonged mice burden swimming
Time, raising fatigue mouse liver glycogen reserves, the tired mouse lactic acid of reduction and urea nitrogen content, are pointed out of the invention with obvious
Antifatigue effect.
The treatment of the antifatigue syndrome of this fatigue resistant health food obtains similar effect.
According to the health products anti-fatigue effect method of inspection, extension yellow Jackets length of one's sleep experiment, yellow Jackets (or
Barbital sodium) to test binomial in three experiments positive for sub-threshold dose hypnosis experiment, yellow Jackets Sleep latency, and without obvious
Direct sleep effect, can determine that given the test agent anti-fatigue effect results of animal is positive.Above experimental result illustrates this health care
Food has anti-fatigue effect.
Animal experiment result confirm that this health food improves significantly to fatigue, it is safe with nontoxicity,
It is orally available, the advantages of edible.
Present invention discover that this health food is positive in antifatigue functional check methods experiment, inferior health shape can be corrected
State or treatment chronic fatigue syndrome；It is described correction sub-health state for increase hepatic glycogen content, reduce full blood lactic content or
Reduce Plasma Urea nitrogen content.Results of animal shows, with extension middle age and Aged Mice walking weight load, increases liver
Glycogen is laid in, and reduces lactic acid, urea nitrogen content, has the advantages that small consumption, safety, injectable, orally available, with larger guarantor
Strong and clinical value.This anti-fatigue effect that the present invention is provided can be applied to prepare anti-fatigue health-product containing or food.
The antifatigue specific research of this health food, for confirm its antifatigue and its healthcare function have realistic meaning and
Application value.
It is an advantage of the invention that：
1. safety, non-toxic, orally available.
2. the function of pair health food has done new exploration, fine supplement is done on the basis of its original knows function, it is found
Antifatigue effect.
3. a health food is oral or instant, there is notable anti-fatigue health-caring function, referrer is about maca with dosage
Do not surpass 25 grams (60kg.BW) daily, the daily consumption of ginseng is no more than 3 grams (60kg.BW).
Brief description of the drawings
Figure 1A is health food of the present invention to first intraperitoneal injection experimental result block diagram of mice burden swimming time；
Figure 1B is health food of the present invention to the oral experimental result block diagram of mice burden swimming time second batch；
Fig. 1 C are that health food of the present invention is tested to the 3rd batch of oral treating chronic effort syndrome of mice burden swimming time
As a result block diagram；
Fig. 2A is health food of the present invention to first intraperitoneal injection experimental result block diagram of mouse liver glycogen reserves；
Fig. 2 B are health food of the present invention to the oral experimental result block diagram of mouse liver glycogen reserves second batch；
Fig. 2 C are that health food of the present invention is tied to the 3rd batch of oral treating chronic effort syndrome experiment of mouse liver glycogen reserves
Fruit block diagram；
Fig. 3 A are health food of the present invention to first intraperitoneal injection experimental result block diagram of Mouse whole blood lactate level；
Fig. 3 B are health food of the present invention to the oral experimental result block diagram of Mouse whole blood lactate level second batch；
Fig. 3 C are that health food of the present invention is tested to the 3rd batch of oral treating chronic effort syndrome of Mouse whole blood lactate level
As a result block diagram；
Fig. 4 A are first intraperitoneal injection experimental result column of health food of the present invention to mice plasma urea nitrogen levels
Figure；
Fig. 4 B are second batch oral experimental result block diagram of the health food of the present invention to mice plasma urea nitrogen levels；
Fig. 4 C are three batch oral treating chronic effort syndrome of the health food of the present invention to mice plasma urea nitrogen levels
Experimental result block diagram.
Embodiment
With reference to embodiment, the invention will be further described.
Embodiment 1：
A kind of fatigue resistant health food, prepares following components by weight：
Maca：30 parts；
Ginseng：12 parts；
Gumbo extract：5 parts；(gumbo extract:For pale yellow powder, by the root of okra, leaf, flower and seed
Extracted after mixing, crushing.Main extraction process：Clear water clean → increases water pulping → filter out residue → concentrate drying.Extract
10%) concentration of effective ingredient is.
Sealwort：4 parts；
Ginkgo biloba extract：1 part；(ginkgo biloba extract：For the powder of sundown to sepia.It is with ginkgo Ginkg
O biloba L. leaf is raw material, using appropriate solvent, the effective component extracts of extraction.Main production flow is：
Ginkgo leaf → clear water, which is cleaned, waits pre-treatment → alcohol extracting → recovery concentration → refined → spray drying.Extract effective ingredient concentration is
20%).
Tribulus terrestris extraction：2 parts；(tribulus terrestris extraction：For brownish-yellow powder, main production flow is：Pierce puncture
Lamb's-quarters raw material → crushing → alcohol extracting → concentration → extraction → drying.Wherein 40%) saponin content is.
Cinnamomum cassia extract：3 parts；(cinnamomum cassia extract：For yellowish-brown powder, mainly from canella Chinese cassia tree Cinnam
The extract obtained in omum cassia Presl bark.Main production flow is：Selection → decoction → diacolation → return
Stream → distillation → precipitation → standing → filtering → concentration → drying.15%) extract effective component content is.
Citrulling：4 parts；
8 parts of L-arginine
Plus 2 parts of pharmaceutic adjuvant microcrystalline celluloses and 1 part of pharmaceutic adjuvant--magnesium stearate, it is made as tablet.
Then supplementary material pulverized and sieved to → premix → drying → whole grain of pelletizing → total mixed → tabletting → coating → inner packing
→ outsourcing → storage.
According to daily 1~2 time, the consumption of each 100-2000mg/kg body weight can also be produced as oral liquid, beverage, glue
Capsule, spray or cutaneous permeable agent.
Embodiment 2：
A kind of fatigue resistant health food, prepares following components by weight：
Maca：35 parts；
Ginseng：16 parts；
Gumbo extract：12 parts；(gumbo extract:For pale yellow powder, by the root of okra, leaf, flower and seed
Extracted after mixing, crushing.Main extraction process：Clear water clean → increases water pulping → filter out residue → concentrate drying.Extract
10%) concentration of effective ingredient is.
Sealwort：10 parts；
Ginkgo biloba extract：3 parts；(ginkgo biloba extract：For the powder of sundown to sepia.It is with ginkgo Ginkg
O biloba L. leaf is raw material, using appropriate solvent, the effective component extracts of extraction.Main production flow is：
Ginkgo leaf → clear water, which is cleaned, waits pre-treatment → alcohol extracting → recovery concentration → refined → spray drying.Extract effective ingredient concentration
For 20%).
Tribulus terrestris extraction：6 parts；Tribulus terrestris extraction：2 parts；(tribulus terrestris extraction：For brownish-yellow powder, mainly
The technological process of production is：Tribulus terrestris raw material → crushing → alcohol extracting → concentration → extraction → drying.Wherein 40%) saponin content is.
Cinnamomum cassia extract：7 parts；(cinnamomum cassia extract：For yellowish-brown powder, mainly from canella Chinese cassia tree Cinnam
The extract obtained in omum cassia Presl bark.Main production flow is：Selection → decoction → diacolation → return
Stream → distillation → precipitation → standing → filtering → concentration → drying.15%) extract effective component content is.
Citrulling：9 parts；
10 parts of L-arginine
Plus 2 parts of pharmaceutic adjuvant microcrystalline celluloses and 1 part of pharmaceutic adjuvant--magnesium stearate, it is made as tablet.
Then supplementary material pulverized and sieved to → premix → drying → whole grain of pelletizing → total mixed → tabletting → coating → inner packing
→ outsourcing → storage.
According to daily 1~2 time, the consumption of each 100-2000mg/kg body weight can also be produced as oral liquid, beverage, glue
Capsule, spray or cutaneous permeable agent.
Embodiment 3：
A kind of fatigue resistant health food, prepares following components by weight：
Maca：32 parts；
Ginseng：14 parts；
Gumbo extract：10 parts；(gumbo extract:For pale yellow powder, by the root of okra, leaf, flower and seed
Extracted after mixing, crushing.Main extraction process：Clear water clean → increases water pulping → filter out residue → concentrate drying.Extract
10%) concentration of effective ingredient is.
Sealwort：8 parts；
Ginkgo biloba extract：2 parts；(ginkgo biloba extract：For the powder of sundown to sepia.It is with ginkgo Ginkg
O biloba L. leaf is raw material, using appropriate solvent, the effective component extracts of extraction.Main production flow is：
Ginkgo leaf → clear water, which is cleaned, waits pre-treatment → alcohol extracting → recovery concentration → refined → spray drying.Extract effective ingredient concentration is
20%).
Tribulus terrestris extraction：5 parts；(tribulus terrestris extraction：For brownish-yellow powder, main production flow is：Pierce puncture
Lamb's-quarters raw material → crushing → alcohol extracting → concentration → extraction → drying.Wherein 40%) saponin content is.
Cinnamomum cassia extract：5 parts；(cinnamomum cassia extract：For yellowish-brown powder, mainly from canella Chinese cassia tree Cinnamo
The extract obtained in mum cassia Presl bark.Main production flow is：Selection → decoction → diacolation → return
Stream → distillation → precipitation → standing → filtering → concentration → drying.15%) extract effective component content is.
Citrulling：6 parts；
9 parts of L-arginine
Plus 2 parts of pharmaceutic adjuvant microcrystalline celluloses and 1 part of pharmaceutic adjuvant--magnesium stearate, it is made as tablet.
Then supplementary material pulverized and sieved to → premix → drying → whole grain of pelletizing → total mixed → tabletting → coating → inner packing
→ outsourcing → storage.
According to daily 1~2 time, the consumption of each 100-2000mg/kg body weight can also be produced as oral liquid, beverage, glue
Capsule, spray or cutaneous permeable agent.
Finally it should be noted that foregoing description is only the preferred embodiments of the present invention, the ordinary skill people of this area
Member on the premise of without prejudice to present inventive concept and claim, can make table as multiple types under the enlightenment of the present invention
Show, such conversion is each fallen within protection scope of the present invention.
Claims (4)
1. a kind of fatigue resistant health food, by weight comprising following components：
2. a kind of fatigue resistant health food according to claim 1, it is characterised in that：The health food is also added with medicinal
Auxiliary material.
3. a kind of fatigue resistant health food according to claim 1, it is characterised in that：The health food is oral liquid, drink
Material, tablet, capsule, spray or cutaneous permeable agent.
4. a kind of preparation method of fatigue resistant health food a kind of as described in claim 1-2, is carried out as follows：Supplementary material
Pulverize and sieve → premix → drying → whole grain of pelletizing → total mixed → tabletting → coating → inner packing → outsourcing → storage.
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| CN113951355A (en) * | 2021-10-15 | 2022-01-21 | 上海舒泽生物科技研究所 | Citrulline tablet candy for promoting synthesis of nitric oxide in human body and preparation method thereof |
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