CN104435351A - Traditional Chinese medicine prescribed preparation for tonifying kidneys and strengthening yang and application of traditional Chinese medicine prescribed preparation - Google Patents
Traditional Chinese medicine prescribed preparation for tonifying kidneys and strengthening yang and application of traditional Chinese medicine prescribed preparation Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
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Abstract
The invention provides a traditional Chinese medicine prescribed preparation for tonifying kidneys and strengthening yang. The preparation is prepared from epimedium, cistanche salsa, semen cuscutae, fructus lycii, schisandra chinensis, fructus rubi, morinda officinalis, astragalus membranaceus, cynomorium songaricum and cornus pulp. The preparation has direct effects on warming yang, promoting libido and sexual function and improving sperm production capability, and has an excellent activity on oligospermia and other symptoms.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate to a kind of kidney invigorating and YANG supporting Chinese prescription medicine for male sterility and application thereof in particular.
Technical background
Human seminal fluid's quality reduces by more than 40% in 50 years in the past, has caused very large concern, the data that the national semen quality of many national reports declines, and China also exists same problem, the tendency wherein become younger is more obvious.The decline of human seminal fluid's quality, causes male fertility to decline, and is related to the health of newborns and race's procreation quality.Chinese medicine to improving semen quality, improve male fecundity aspect there is peculiar advantage, arrange and excavate the peculiar resource of China Chinese Traditional Medicine treasure-house, will make a due contribution to raising China male reproductive health level.
The traditional Chinese medical science, to the understanding of reproduction theory and clinical practice, is embodied in the research of Kidney Theory in TCM: kidney occupies critical role in traditional Chinese medical science state of internal organs theory, and its function is extensive, it is special to act on, have the concept dominating life, therefore successive dynasties Chinese medicine man claims: " the kidney being the origin of congenital constitution, the root of life ".Kidney and growth in humans, growth, aging have substantial connection.The traditional Chinese medical science thinks at all being " kidney " of reproduction, using kidney qi, menses, male smart female's blood as material base.Kidney essense is sufficient, and kidney qi is vigorous, and reproductive function is normal; Deficiency of kidney-essence, kidney qi virtual loss, reproductive function is abnormal.Therefore, excavating Chinese Traditional Medicine treasure-house, is China's reproduction and the distinctive advantage of health research.
Summary of the invention
For the problems referred to above, the invention provides a kind of kidney invigorating and YANG supporting Chinese prescription medicine, described prescription comprises Herba Epimedii, Herba Cistanches, Semen Cuscutae, Fructus Lycii, Fructus Schisandrae Chinensis, Fructus Rubi, Radix Morindae Officinalis, the Radix Astragali, Herba Cynomorii, Fructus Corni.
Semen Plantaginis, Radix Codonopsis, Rhizoma Dioscoreae is also added, Radix Glycyrrhizae in described prescription.
Radix Rehmanniae Preparata, Rhizoma Polygonati, Semen Myristicae, Rhizoma Dioscoreae, Radix Ginseng Rubra is also added in described prescription.
Radix Rehmanniae Preparata, Semen Plantaginis, Poria, Radix Codonopsis, Rhizoma Dioscoreae is also added, Radix Glycyrrhizae in described prescription.
Semen Plantaginis, Radix Polygoni Multiflori Preparata, Radix Codonopsis, Radix Glycyrrhizae is also added in described prescription.
Weight ratio 1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-the 10:1-10:1-10 of described Herba Epimedii, Herba Cistanches, Semen Cuscutae, Fructus Lycii, Fructus Schisandrae Chinensis, Fructus Rubi, Radix Morindae Officinalis, the Radix Astragali, Herba Cynomorii, Fructus Corni, Semen Plantaginis, Radix Codonopsis, Rhizoma Dioscoreae and Radix Glycyrrhizae.
Weight ratio 1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-the 10:1-10:1-10 of described Herba Epimedii, Herba Cistanches, Semen Cuscutae, Fructus Lycii, Fructus Schisandrae Chinensis, Fructus Rubi, Radix Morindae Officinalis, the Radix Astragali, Herba Cynomorii, Fructus Corni, Radix Rehmanniae Preparata, Rhizoma Polygonati, Semen Myristicae, Rhizoma Dioscoreae and Radix Ginseng Rubra.
Described Herba Epimedii, Herba Cistanches, Semen Cuscutae, Fructus Lycii, Fructus Schisandrae Chinensis, Fructus Rubi, Radix Morindae Officinalis, the Radix Astragali, Herba Cynomorii, Fructus Corni, Radix Rehmanniae Preparata, Semen Plantaginis, Poria, the weight ratio 1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10 of Radix Codonopsis, Rhizoma Dioscoreae and Radix Glycyrrhizae.
Weight ratio 1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-the 10:1-10:1-10 of described Herba Epimedii, Herba Cistanches, Semen Cuscutae, Fructus Lycii, Fructus Schisandrae Chinensis, Fructus Rubi, Radix Morindae Officinalis, the Radix Astragali, Herba Cynomorii, Fructus Corni, Semen Plantaginis, Radix Polygoni Multiflori Preparata, Radix Codonopsis and Radix Glycyrrhizae.
The application of above-mentioned arbitrary described kidney invigorating and YANG supporting Chinese prescription medicine in preparation treatment oligospermatism medicine.
Advantageous Effects of the present invention is: prescription provided by the invention has warming YANG, sexual desire promoting and sexual function, raising energy generative capacity has direct effect; For diseases such as oligospermatisms, there is good activity.
Detailed description of the invention
The activity of embodiment 1 kidney invigorating and YANG supporting Chinese prescription medicine investigates 1
The preparation of laboratory sample
Weight ratio 8:2:8:4:5:7:3:5:2:6 according to Herba Epimedii, Herba Cistanches, Semen Cuscutae, Fructus Lycii, Fructus Schisandrae Chinensis, Fructus Rubi, Radix Morindae Officinalis, the Radix Astragali, Herba Cynomorii and Fructus Corni takes medical material, with 5 times of weight 70% alcohol reflux 1h, reclaim extracting solution, concentrated extract, obtains basic side A group.
Weight ratio 8:2:8:4:5:7:3:5:2:6:5:2:6:2 according to Herba Epimedii, Herba Cistanches, Semen Cuscutae, Fructus Lycii, Fructus Schisandrae Chinensis, Fructus Rubi, Radix Morindae Officinalis, the Radix Astragali, Herba Cynomorii, Fructus Corni, Semen Plantaginis, Radix Codonopsis, Rhizoma Dioscoreae and Radix Glycyrrhizae takes medical material, with 5 times of weight 70% alcohol reflux 1h, reclaim extracting solution, concentrated extract, obtains experiment A-1 group.
Weight ratio 1:10:2:9:1:2:8:3:9:2:7:8:2:10 according to Herba Epimedii, Herba Cistanches, Semen Cuscutae, Fructus Lycii, Fructus Schisandrae Chinensis, Fructus Rubi, Radix Morindae Officinalis, the Radix Astragali, Herba Cynomorii, Fructus Corni, Semen Plantaginis, Radix Codonopsis, Rhizoma Dioscoreae and Radix Glycyrrhizae takes medical material, with 5 times of weight 70% alcohol reflux 1h, reclaim extracting solution, concentrated extract, obtains experiment A-2 group.
Weight ratio 10:1:10:2:9:7:2:8:9:8:2:2:7:2 according to Herba Epimedii, Herba Cistanches, Semen Cuscutae, Fructus Lycii, Fructus Schisandrae Chinensis, Fructus Rubi, Radix Morindae Officinalis, the Radix Astragali, Herba Cynomorii, Fructus Corni, Semen Plantaginis, Radix Codonopsis, Rhizoma Dioscoreae and Radix Glycyrrhizae takes medical material, with 5 times of weight 70% alcohol reflux 1h, reclaim extracting solution, concentrated extract, obtains experiment A-3 group.
The activity of drug regimen is investigated
Select specific pathogen free bacterium (SPF level, three grades of animals) NIH male mice in adult 15 week age.1st batch of test, 50 mices, Normal group 10, ad lib routine is raised; Busulfan modeling animal 60, according to the modeling of busulfan induction azoospermia model conventional method: busulfan (sigma product) is dissolved in DMSO and is mixed with 2% medicinal liquid.After 40mg/kg intraperitoneal single injection administration modeling, integral animal performance meets the outward appearance sign of Kidney Theory in TCM yang deficiency syndrome, shows as the symptoms such as appetite reduces, body weight does not increase or alleviates, curling oneself up is weak, activity obviously reduces, dispirited, bradykinesia, auricle are pale, blink, surrounding eyelids edema, fur are curling, perpendicular hair wrinkle tuft, fur tarnish, polyuria.After 40d, surviving animals 43 (mortality rate 25%) is divided into clear-cutting forestland 7, five-seed Yanzong 6, basic side A group 6, experiment A-1 group 6, experiment A-2 group 6 and experiment A-3 group 6.
Five-seed Yanzong is the Wuziyanzong tablets described in " Chinese Pharmacopoeia " 2010 editions first, convert according to clinical 10 multiple doses of people, the mice gastric infusion every day amount of five-seed Yanzong, basic side A group, experiment A-1 group, experiment A-2 group and experiment A-3 group is equivalent to (crude drug) 2.8g/kg.Successive administration 78d (mice 2 spermatogenic cycles).
Animal break ridge put to death draw materials, epididymis, in containing shredding in 2ml culture fluid capsule, being hatched for 36.5 DEG C and being made the fully free swimming 30min of sperm, gets the sperm suspension that dissociates and drips on microscope slide, microscopy spermatozoa motility index, observes 200 sperm analysis sperm motilities and a.b, c, d level sperm percentage rate.Testis is fixing in Bouin, and routine paraffin wax embeds, and 5 sections, HE dyes, microscopy.According to animal tissue's morphologic features, sperm swimming test and sperm number analysis, the action effect of Chinese medicine is evaluated.
After administration, each group administration animal, its insufficiency of kidney-YANG symptom is obviously improved, and integral animal performance is close to normal, and spirit is vigorous, and fur gloss is submissive.
Represent (2 amounts of stressing are added divided by 2) with one-sided testis and epididymis tissue weight, after modeling, the obvious atrophy of clear-cutting forestland animal testis diminishes, and each administration treated animal testis obviously increases.Specifically be shown in Table 1.
The each treated animal weight of reproductive organs of table 1
Note: compare * P ﹤ 0.05, * * P ﹤ 0.01 with Normal group, compare #P ﹤ 0.05, ##P ﹤ 0.01 with natural recovering group.
From the data of table 1; Testis tissue weight only has about 50% (P ﹤ 0.01) of Normal group in natural recovering group, five-seed Yanzong, basic side A group, experiment A-1 group, experiment A-2 group and experiment A-3 group compare with matched group significant difference (P ﹤ 0.05), but experiment A-1 group has reached 91% of matched group in table 1.Seminal vesicle and prostate, perineum complex ask equal zero difference (equal P ﹥ 0.05) at each group.
Sperm motility and number are shown in Table 2.
The each treated animal weight of reproductive organs of table 2
Note: compare * P ﹤ 0.05, * * P ﹤ 0.01 with Normal group, compare #P ﹤ 0.05, ##P ﹤ 0.01 with natural recovering group.
As shown in Table 2, what each group of administration reached Normal group respectively at sperm motility all reaches more than 70%; A+b level sperm reaches more than 60% of Normal group respectively; Sperm count reaches more than 80% of Normal group respectively; Relative to natural recovering group, every activity of each administration group has all exceeded 3 times of natural recovering group, especially tests its activity of A-1 group optimum in each administration group.
The activity of embodiment 2 kidney invigorating and YANG supporting Chinese prescription medicine investigates 2
The preparation of laboratory sample
Weight ratio 5:7:4:6:3:4:8:9:8:3 according to Herba Epimedii, Herba Cistanches, Semen Cuscutae, Fructus Lycii, Fructus Schisandrae Chinensis, Fructus Rubi, Radix Morindae Officinalis, the Radix Astragali, Herba Cynomorii and Fructus Corni takes medical material, with 5 times of weight 70% alcohol reflux 1h, reclaim extracting solution, concentrated extract, obtains basic side B group.
According to Herba Epimedii, Herba Cistanches, Semen Cuscutae, Fructus Lycii, the weight ratio 1:2:9:2:10:2:2:1:4:10:2:10:2:9 of Fructus Schisandrae Chinensis, Fructus Rubi, Radix Morindae Officinalis, the Radix Astragali, Herba Cynomorii, Fructus Corni, Radix Rehmanniae Preparata, Rhizoma Polygonati, Semen Myristicae, Rhizoma Dioscoreae and Radix Ginseng Rubra takes medical material, with 5 times of weight 70% alcohol reflux 1h, reclaim extracting solution, concentrated extract, obtains experiment B-1 group.
According to Herba Epimedii, Herba Cistanches, Semen Cuscutae, Fructus Lycii, the weight ratio 5:7:4:6:3:4:8:9:8:3:5:2:6:2 of Fructus Schisandrae Chinensis, Fructus Rubi, Radix Morindae Officinalis, the Radix Astragali, Herba Cynomorii, Fructus Corni, Radix Rehmanniae Preparata, Rhizoma Polygonati, Semen Myristicae, Rhizoma Dioscoreae and Radix Ginseng Rubra takes medical material, with 5 times of weight 70% alcohol reflux 1h, reclaim extracting solution, concentrated extract, obtains experiment B-2 group.
According to Herba Epimedii, Herba Cistanches, Semen Cuscutae, Fructus Lycii, the weight ratio 1:2:9:2:10:2:2:1:4:10:2:10:2:9 of Fructus Schisandrae Chinensis, Fructus Rubi, Radix Morindae Officinalis, the Radix Astragali, Herba Cynomorii, Fructus Corni, Radix Rehmanniae Preparata, Rhizoma Polygonati, Semen Myristicae, Rhizoma Dioscoreae and Radix Ginseng Rubra takes medical material, with 5 times of weight 70% alcohol reflux 1h, reclaim extracting solution, concentrated extract, obtains experiment B-3 group.
The activity of drug regimen is investigated
Select specific pathogen free bacterium (SPF level, three grades of animals) NIH male mice in adult 15 week age.1st batch of test, 50 mices, Normal group 10, ad lib routine is raised; Busulfan modeling animal 60, according to the modeling of busulfan induction azoospermia model conventional method: busulfan (sigma product) is dissolved in DMSO and is mixed with 2% medicinal liquid.After 40mg/kg intraperitoneal single injection administration modeling, integral animal performance meets the outward appearance sign of Kidney Theory in TCM yang deficiency syndrome, shows as the symptoms such as appetite reduces, body weight does not increase or alleviates, curling oneself up is weak, activity obviously reduces, dispirited, bradykinesia, auricle are pale, blink, surrounding eyelids edema, fur are curling, perpendicular hair wrinkle tuft, fur tarnish, polyuria.After 40d, surviving animals 45 (mortality rate 25%) is divided into clear-cutting forestland 7, five-seed Yanzong 7, basic side B group 7, experiment B-1 group 6, experiment B-2 group 6 and experiment B-3 group 6.
Five-seed Yanzong is the Wuziyanzong tablets described in " Chinese Pharmacopoeia " 2010 editions first, convert according to clinical 10 multiple doses of people, the mice gastric infusion every day amount of five-seed Yanzong, basic side B group, experiment B-1 group, experiment B-2 group and experiment B-3 group is equivalent to (crude drug) 2.8g/kg.Successive administration 78d (mice 2 spermatogenic cycles).
The method action effect to the medicine of above-mentioned preparation identical with embodiment 1 is adopted to evaluate.
After administration, each group administration animal, its insufficiency of kidney-YANG symptom is obviously improved, and integral animal performance is close to normal, and spirit is vigorous, and fur gloss is submissive.
Represent (2 amounts of stressing are added divided by 2) with one-sided testis and epididymis tissue weight, after modeling, the obvious atrophy of clear-cutting forestland animal testis diminishes, and each administration treated animal testis obviously increases.Specifically be shown in Table 3.
The each treated animal weight of reproductive organs of table 3
Note: compare * P ﹤ 0.05, * * P ﹤ 0.01 with Normal group, compare #P ﹤ 0.05, ##P ﹤ 0.01 with natural recovering group.
From the data of table 3; Testis tissue weight only has about 50% (P ﹤ 0.01) of Normal group in natural recovering group, five-seed Yanzong, basic side B group, experiment B-1 group, experiment B-2 group and experiment B-3 group compare with matched group significant difference (P ﹤ 0.05), but experiment B-2 group has reached 91% of matched group in table 3.Seminal vesicle and prostate, perineum complex ask equal zero difference (equal P ﹥ 0.05) at each group.
Sperm motility and number are shown in Table 4.
The each treated animal weight of reproductive organs of table 4
Note: compare * P ﹤ 0.05, * * P ﹤ 0.01 with Normal group, compare #P ﹤ 0.05, ##P ﹤ 0.01 with natural recovering group.
As shown in Table 4, what each group of administration reached Normal group respectively at sperm motility all reaches more than 70%; A+b level sperm reaches more than 60% of Normal group respectively; Sperm count reaches more than 80% of Normal group respectively; Relative to natural recovering group, every activity of each administration group has all exceeded 3 times of natural recovering group, especially tests its activity of B-2 group optimum in each administration group.
The activity of embodiment 3 kidney invigorating and YANG supporting Chinese prescription medicine investigates 3
The preparation of laboratory sample
Weight ratio 8:8:5:6:3:4:8:9:8:2 according to Herba Epimedii, Herba Cistanches, Semen Cuscutae, Fructus Lycii, Fructus Schisandrae Chinensis, Fructus Rubi, Radix Morindae Officinalis, the Radix Astragali, Herba Cynomorii and Fructus Corni takes medical material, with 5 times of weight 70% alcohol reflux 1h, reclaim extracting solution, concentrated extract, obtains basic side C group.
According to Herba Epimedii, Herba Cistanches, Semen Cuscutae, Fructus Lycii, Fructus Schisandrae Chinensis, Fructus Rubi, Radix Morindae Officinalis, the Radix Astragali, Herba Cynomorii, Fructus Corni, Radix Rehmanniae Preparata, Semen Plantaginis, Poria, the weight ratio 8:8:5:6:3:4:8:9:8:2:2:10:2:9:10:2 of Radix Codonopsis, Rhizoma Dioscoreae and Radix Glycyrrhizae takes medical material, with 5 times of weight 70% alcohol reflux 1h, reclaim extracting solution, concentrated extract, obtains experiment C-1 group.
According to Herba Epimedii, Herba Cistanches, Semen Cuscutae, Fructus Lycii, Fructus Schisandrae Chinensis, Fructus Rubi, Radix Morindae Officinalis, the Radix Astragali, Herba Cynomorii, Fructus Corni, Radix Rehmanniae Preparata, Semen Plantaginis, Poria, the weight ratio 2:7:9:6:3:4:8:9:8:3:5:2:6:2:8:2 of Radix Codonopsis, Rhizoma Dioscoreae and Radix Glycyrrhizae takes medical material, with 5 times of weight 70% alcohol reflux 1h, reclaim extracting solution, concentrated extract, obtains experiment C-2 group.
According to Herba Epimedii, Herba Cistanches, Semen Cuscutae, Fructus Lycii, Fructus Schisandrae Chinensis, Fructus Rubi, Radix Morindae Officinalis, the Radix Astragali, Herba Cynomorii, Fructus Corni, Radix Rehmanniae Preparata, Semen Plantaginis, Poria, the weight ratio 10:2:3:2:10:2:2:1:4:10:2:10:2:9 of Radix Codonopsis, Rhizoma Dioscoreae and Radix Glycyrrhizae takes medical material, with 5 times of weight 70% alcohol reflux 1h, reclaim extracting solution, concentrated extract, obtains experiment C-3 group.
The activity of drug regimen is investigated
Select specific pathogen free bacterium (SPF level, three grades of animals) NIH male mice in adult 15 week age.1st batch of test, 50 mices, Normal group 10, ad lib routine is raised; Busulfan modeling animal 60, according to the modeling of busulfan induction azoospermia model conventional method: busulfan (sigma product) is dissolved in DMSO and is mixed with 2% medicinal liquid.After 40mg/kg intraperitoneal single injection administration modeling, integral animal performance meets the outward appearance sign of Kidney Theory in TCM yang deficiency syndrome, shows as the symptoms such as appetite reduces, body weight does not increase or alleviates, curling oneself up is weak, activity obviously reduces, dispirited, bradykinesia, auricle are pale, blink, surrounding eyelids edema, fur are curling, perpendicular hair wrinkle tuft, fur tarnish, polyuria.After 40d, surviving animals 45 (mortality rate 25%) is divided into clear-cutting forestland 7, five-seed Yanzong 7, basic side C group 7, experiment C-1 group 6, experiment C-2 group 6 and experiment C-3 group 6.
Five-seed Yanzong is the Wuziyanzong tablets described in " Chinese Pharmacopoeia " 2010 editions first, convert according to clinical 10 multiple doses of people, the mice gastric infusion every day amount of five-seed Yanzong, basic side C group, experiment C-1 group, experiment C-2 group and experiment C-3 group is equivalent to (crude drug) 2.8g/kg.Successive administration 78d (mice 2 spermatogenic cycles).
The method action effect to the medicine of above-mentioned preparation identical with embodiment 1 is adopted to evaluate.
After administration, each group administration animal, its insufficiency of kidney-YANG symptom is obviously improved, and integral animal performance is close to normal, and spirit is vigorous, and fur gloss is submissive.
Represent (2 amounts of stressing are added divided by 2) with one-sided testis and epididymis tissue weight, after modeling, the obvious atrophy of clear-cutting forestland animal testis diminishes, and each administration treated animal testis obviously increases.Specifically be shown in Table 5.
The each treated animal weight of reproductive organs of table 5
Note: compare * P ﹤ 0.05, * * P ﹤ 0.01 with Normal group, compare #P ﹤ 0.05, ##P ﹤ 0.01 with natural recovering group.
From the data of table 5; Testis tissue weight only has about 50% (P ﹤ 0.01) of Normal group in natural recovering group, five-seed Yanzong, basic side C group, experiment C-1 group, experiment C-2 group and experiment C-3 group compare with matched group significant difference (P ﹤ 0.05), but experiment C-1 group has reached 91% of matched group in table 5.Seminal vesicle and prostate, perineum complex ask equal zero difference (equal P ﹥ 0.05) at each group.
Sperm motility and number are shown in Table 6.
The each treated animal weight of reproductive organs of table 6
Note: compare * P ﹤ 0.05, * * P ﹤ 0.01 with Normal group, compare #P ﹤ 0.05, ##P ﹤ 0.01 with natural recovering group.
As shown in Table 6, what each group of administration reached Normal group respectively at sperm motility all reaches more than 70%; A+b level sperm reaches more than 60% of Normal group respectively; Sperm count reaches more than 80% of Normal group respectively; Relative to natural recovering group, every activity of each administration group has all exceeded 3 times of natural recovering group, especially tests its activity of C-1 group optimum in each administration group.
The activity of embodiment 3 kidney invigorating and YANG supporting Chinese prescription medicine investigates 3
The preparation of laboratory sample
Weight ratio 8:8:5:6:3:4:8:9:8:2 according to Herba Epimedii, Herba Cistanches, Semen Cuscutae, Fructus Lycii, Fructus Schisandrae Chinensis, Fructus Rubi, Radix Morindae Officinalis, the Radix Astragali, Herba Cynomorii and Fructus Corni takes medical material, with 5 times of weight 70% alcohol reflux 1h, reclaim extracting solution, concentrated extract, obtains basic side D group.
According to Herba Epimedii, Herba Cistanches, Semen Cuscutae, Fructus Lycii, Fructus Schisandrae Chinensis, Fructus Rubi, Radix Morindae Officinalis, the Radix Astragali, Herba Cynomorii, Fructus Corni, Radix Rehmanniae Preparata, Semen Plantaginis, Poria, the weight ratio 8:8:5:6:3:4:8:9:8:2:2:10:2:9:10:2 of Radix Codonopsis, Rhizoma Dioscoreae and Radix Glycyrrhizae takes medical material, with 5 times of weight 70% alcohol reflux 1h, reclaim extracting solution, concentrated extract, obtains experiment D-1 group.
According to Herba Epimedii, Herba Cistanches, Semen Cuscutae, Fructus Lycii, Fructus Schisandrae Chinensis, Fructus Rubi, Radix Morindae Officinalis, the Radix Astragali, Herba Cynomorii, Fructus Corni, Radix Rehmanniae Preparata, Semen Plantaginis, Poria, the weight ratio 2:7:9:6:3:4:8:9:8:3:5:2:6:2:8:2 of Radix Codonopsis, Rhizoma Dioscoreae and Radix Glycyrrhizae takes medical material, with 5 times of weight 70% alcohol reflux 1h, reclaim extracting solution, concentrated extract, obtains experiment D-2 group.
According to Herba Epimedii, Herba Cistanches, Semen Cuscutae, Fructus Lycii, Fructus Schisandrae Chinensis, Fructus Rubi, Radix Morindae Officinalis, the Radix Astragali, Herba Cynomorii, Fructus Corni, Radix Rehmanniae Preparata, Semen Plantaginis, Poria, the weight ratio 10:2:3:2:10:2:2:1:4:10:2:10:2:9 of Radix Codonopsis, Rhizoma Dioscoreae and Radix Glycyrrhizae takes medical material, with 5 times of weight 70% alcohol reflux 1h, reclaim extracting solution, concentrated extract, obtains experiment D-3 group.
The activity of drug regimen is investigated
Select specific pathogen free bacterium (SPF level, three grades of animals) NIH male mice in adult 15 week age.1st batch of test, 50 mices, Normal group 10, ad lib routine is raised; Busulfan modeling animal 60, according to the modeling of busulfan induction azoospermia model conventional method: busulfan (sigma product) is dissolved in DMSO and is mixed with 2% medicinal liquid.After 40mg/kg intraperitoneal single injection administration modeling, integral animal performance meets the outward appearance sign of Kidney Theory in TCM yang deficiency syndrome, shows as the symptoms such as appetite reduces, body weight does not increase or alleviates, curling oneself up is weak, activity obviously reduces, dispirited, bradykinesia, auricle are pale, blink, surrounding eyelids edema, fur are curling, perpendicular hair wrinkle tuft, fur tarnish, polyuria.After 40d, surviving animals 45 (mortality rate 25%) is divided into clear-cutting forestland 7, five-seed Yanzong 7, basic side D group 7, experiment D-1 group 6, experiment D-2 group 6 and experiment D-3 group 6.
Five-seed Yanzong is the Wuziyanzong tablets described in " Chinese Pharmacopoeia " 2010 editions first, convert according to clinical 10 multiple doses of people, the mice gastric infusion every day amount of five-seed Yanzong, basic side D group, experiment D-1 group, experiment D-2 group and experiment D-3 group is equivalent to (crude drug) 2.8g/kg.Successive administration 78d (mice 2 spermatogenic cycles).
The method action effect to the medicine of above-mentioned preparation identical with embodiment 1 is adopted to evaluate.
After administration, each group administration animal, its insufficiency of kidney-YANG symptom is obviously improved, and integral animal performance is close to normal, and spirit is vigorous, and fur gloss is submissive.
Represent (2 amounts of stressing are added divided by 2) with one-sided testis and epididymis tissue weight, after modeling, the obvious atrophy of clear-cutting forestland animal testis diminishes, and each administration treated animal testis obviously increases.Specifically be shown in Table 7.
The each treated animal weight of reproductive organs of table 7
Note: compare * P ﹤ 0.05, * * P ﹤ 0.01 with Normal group, compare #P ﹤ 0.05, ##P ﹤ 0.01 with natural recovering group.
From the data of table 7; Testis tissue weight only has about 50% (P ﹤ 0.01) of Normal group in natural recovering group, five-seed Yanzong, basic side D group, experiment D-1 group, experiment D-2 group and experiment D-3 group compare with matched group significant difference (P ﹤ 0.05), but experiment D-1 group has reached 91% of matched group in table 7.Seminal vesicle and prostate, perineum complex ask equal zero difference (equal P ﹥ 0.05) at each group.
Sperm motility and number are shown in Table 8.
The each treated animal weight of reproductive organs of table 8
Note: compare * P ﹤ 0.05, * * P ﹤ 0.01 with Normal group, compare #P ﹤ 0.05, ##P ﹤ 0.01 with natural recovering group.
As shown in Table 8, what each group of administration reached Normal group respectively at sperm motility all reaches more than 70%; A+b level sperm reaches more than 60% of Normal group respectively; Sperm count reaches more than 80% of Normal group respectively; Relative to natural recovering group, every activity of each administration group has all exceeded 3 times of natural recovering group, especially tests its activity of D-1 group optimum in each administration group.
Above-mentioned four embodiment data display; kidney invigorating and YANG supporting Chinese prescription drug effect is in the spermatogenic cell of testis; after display spermatogenesis stem cell suffers damage (busulfan modeling is inherently to the coup injury of cell), there is the effect of protection spermatogenic cell, spermatogenesis recovered, vigorous.Also there is protection spermatogenesis stem cell, differentiation-inducing effect.Kidney invigorating and YANG supporting Chinese prescription relates to kidney essense.The material base of kidney qi: kidney invigorating and YANG supporting Chinese prescription Main Function be first promote testis to ask cell plastid number and function obviously strengthen, directly can facilitate the secretion of testosterone, make spermatogenesis improvement of environment, indirectly reach the effect promoting spermatogenesis, embody the effect biasing toward " kidney qi " aspect.This is consistent with usage clinically, because the increase of androgen secretion, has warming YANG, sexual desire promoting and sexual function, raising energy generative capacity has direct effect.And directly promote that the division of spermatogenic epithelium increases, in convoluted seminiferous tubule, spermatogonium and primary spermatocyte number obviously increase, and show to have the effect directly promoting spermatogenesis stem cell and spermatogenic cells at different stages.
Claims (10)
1. a kidney invigorating and YANG supporting Chinese prescription medicine, is characterized in that: described prescription comprises Herba Epimedii, Herba Cistanches, Semen Cuscutae, Fructus Lycii, Fructus Schisandrae Chinensis, Fructus Rubi, Radix Morindae Officinalis, the Radix Astragali, Herba Cynomorii, Fructus Corni.
2. kidney invigorating and YANG supporting Chinese prescription medicine according to claim 1, is characterized in that: also added Semen Plantaginis, Radix Codonopsis, Rhizoma Dioscoreae in described prescription, Radix Glycyrrhizae.
3. kidney invigorating and YANG supporting Chinese prescription medicine according to claim 1, is characterized in that: also added Radix Rehmanniae Preparata, Rhizoma Polygonati, Semen Myristicae, Rhizoma Dioscoreae, Radix Ginseng Rubra in described prescription.
4. kidney invigorating and YANG supporting Chinese prescription medicine according to claim 1, is characterized in that: also added Radix Rehmanniae Preparata, Semen Plantaginis, Poria in described prescription, Radix Codonopsis, Rhizoma Dioscoreae, Radix Glycyrrhizae.
5. kidney invigorating and YANG supporting Chinese prescription medicine according to claim 1, is characterized in that: also added Semen Plantaginis, Radix Polygoni Multiflori Preparata, Radix Codonopsis, Radix Glycyrrhizae in described prescription.
6. kidney invigorating and YANG supporting Chinese prescription medicine according to claim 2, is characterized in that: the weight ratio 1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10 of described Herba Epimedii, Herba Cistanches, Semen Cuscutae, Fructus Lycii, Fructus Schisandrae Chinensis, Fructus Rubi, Radix Morindae Officinalis, the Radix Astragali, Herba Cynomorii, Fructus Corni, Semen Plantaginis, Radix Codonopsis, Rhizoma Dioscoreae and Radix Glycyrrhizae.
7. kidney invigorating and YANG supporting Chinese prescription medicine according to claim 3, is characterized in that: the weight ratio 1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10 of described Herba Epimedii, Herba Cistanches, Semen Cuscutae, Fructus Lycii, Fructus Schisandrae Chinensis, Fructus Rubi, Radix Morindae Officinalis, the Radix Astragali, Herba Cynomorii, Fructus Corni, Radix Rehmanniae Preparata, Rhizoma Polygonati, Semen Myristicae, Rhizoma Dioscoreae and Radix Ginseng Rubra.
8. kidney invigorating and YANG supporting Chinese prescription medicine according to claim 4, it is characterized in that: described Herba Epimedii, Herba Cistanches, Semen Cuscutae, Fructus Lycii, Fructus Schisandrae Chinensis, Fructus Rubi, Radix Morindae Officinalis, the Radix Astragali, Herba Cynomorii, Fructus Corni, Radix Rehmanniae Preparata, Semen Plantaginis, Poria, the weight ratio 1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10 of Radix Codonopsis, Rhizoma Dioscoreae and Radix Glycyrrhizae.
9. kidney invigorating and YANG supporting Chinese prescription medicine according to claim 5, is characterized in that: the weight ratio 1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10:1-10 of described Herba Epimedii, Herba Cistanches, Semen Cuscutae, Fructus Lycii, Fructus Schisandrae Chinensis, Fructus Rubi, Radix Morindae Officinalis, the Radix Astragali, Herba Cynomorii, Fructus Corni, Semen Plantaginis, Radix Polygoni Multiflori Preparata, Radix Codonopsis and Radix Glycyrrhizae.
10. the application of the arbitrary described kidney invigorating and YANG supporting Chinese prescription medicine of claim 1-9 in preparation treatment oligospermatism medicine.
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| CN110100928A (en) * | 2019-06-21 | 2019-08-09 | 孙玉东 | A kind of cardiotonic tea and preparation method thereof improving function of male |
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