CN102973708B - Anti-aging traditional Chinese medicine composition and preparation method thereof - Google Patents
Anti-aging traditional Chinese medicine composition and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to an anti-aging traditional Chinese medicine composition and a preparation method thereof. The anti-aging traditional Chinese medicine composition is prepared from glossy privet fruits, eclipta, American ginseng, rehmannia, salvia root, psoralea fruits. The traditional Chinese medicine composition aims at aging-causing factors, from the overall, to achieve multi-level repression of the aging process in many ways; and via comprehensive regulation of immune function of one's body, improves the capability of anti-oxygen free radicals of the body, and tonifies qi and replenishes blood, so as to achieve the role of delaying aging of the body. The traditional Chinese medicine composition has the efficacy of reinforcing the healthy qi and tonifying the deficiency, and fighting aging and promoting longevity, and is suitable for the middle-aged and elderly to take.
Description
One, technical field
The present invention relates to a kind of delay aging drug composition and method of making the same, belong to drug world.
Two, background technology
Aging the carrying out property that to be organism occur in later stage of life, general, many-side, incremental degenerative process are development trends inevitable in physiological process.Human senility shows as a certain part or a certain organ morphology or functional deterioration, is the reaction of animal economy aging, is body development, growth, the strong inexorable law of containing, failing physiological process.Under normal circumstances, people's the inborn life-span should be more than at the age of one hundred years old, but current most people is due to the accident that can not resist, and pathogenic factor invasion and attack and cross presenility so the clear and definite origin cause of formation of aging, and are taked corresponding measure, prevents or the generation of slow down aging.
People generally believe that old and feeble main cause has free-radical oxidation theory, immunologic derangement theory, hypoendocrinism theory and blood stasis causes of senescence etc.
Free-radical oxidation theory is thought: in body, too much super oxygen cation normal tissue and cell has damage, with advancing age, the ability of removing free radical in body weakens increasingly, and the comprehensive old and feeble performance such as occur being slow in action, hypomnesis, malaise, fear of cold, dedentition turn white.Pharmacological experiments shows that much Chinese medicine is eliminated as Radix Codonopsis, Radix Angelicae Sinensis, Rhizoma Polygonati, Rhizoma Polygonati Odorati, Radix Panacis Quinquefolii, Cortex Cinnamomi, Fructus Ligustri Lucidi, Cordyceps, Radix Ophiopogonis, Colla Corii Asini, Cornu Cervi Pantotrichum, Rhizoma Gastrodiae, Ganoderma, the Radix Rehmanniae, Herb Gynostemmae Pentaphylli, Radix Polygoni Multiflori, the Radix Astragali etc. have and antagonist inner lipid peroxidase forms, thereby make free radical reduce the effect of slow down aging, and the Chinese medicines such as Herba Equiseti Hiemalis, Fructus Rosae Normalis, Radix Rhodiolae, Fructus Hippophae, Radix Et Caulis Acanthopanacis Senticosi, Herba Apocyni veneti, Herb Gynostemmae Pentaphylli can improve body SOD content and activity, the defence capability of enhancing body to free radical damage.
With age, the immunoreation of exogenous antigen reduces the mankind, and the immunity of autoantigen is increased.Immune aging be mainly the secretion vigor of immune center organ thymus and marrow hemopoietic stem cells, the degeneration of cell differentiation, it shows as cellular immune function and lowers, humoral immune function is disorderly, so regulate immunologic function with regard to delaying sanility.Research shows that Chinese medicine can be used for regulating and improving old people's body's immunity, and slow down aging, as Lentinus Edodes, Bulbus Lilii, Fructus Lycii etc. can be improved peripheral blood lymphocyte quantity; Radix Ginseng, the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, the Rhizoma Atractylodis Macrocephalae, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Mori, Herba Taraxaci etc. can activated T cells, improve peripheral blood lymphoblast superantigen conversion ratio; Radix Panacis Quinquefolii, Radix Bupleuri etc. can strengthen bone-marrow-derived lymphocyte function, the formation of enhancing antibody; Ganoderma, Poria, Calculus Bovis, Rhizoma Curculiginis etc. are improved the phagocytic activity of macrophage and reticuloendothelial cell; Fructus Corni, Radix Angelicae Sinensis, Ganoderma, Radix Rehmanniae etc. can be improved t subset lymphocyte count; Herba Epimedii, Radix Codonopsis, Radix Rhodiolae, Cordyceps can strengthen cellular immune function.
Neuroendocrine theory is thought: hypothalamus is old and feeble Pacemaker cardiac, it is the integration center that connects nerve, endocrine, immunity, its regulatory function goes down and not only makes itself the processing of the various information feedbacks of internal and external environment variation to be tending towards to blunt, also can involve the function of each target gland of subordinate simultaneously, disorder of hormone secretion, accelerates whole aging course.Research shows that Chinese medicine has the neuroendocrine function of improvement and hormonal balance effect aspect neuroendocrine, thereby reach the object of slow down aging, as Radix Morindae Officinalis, Rhizoma Curculiginis, Herba Epimedii, Radix Et Caulis Acanthopanacis Senticosi, Radix Angelicae Sinensis etc. can promote adrenal cortex function, make hypophysis, the adrenal gland of hypertrophy or atrophy recover normal.Radix Ginseng, Radix Polygoni Multiflori, Herba Cistanches, Fructus Psoraleae, Cordyceps, Radix Glycyrrhizae, the Rhizoma Atractylodis Macrocephalae, the Cortex Eucommiae, the Radix Rehmanniae, Ganoderma, Radix Panacis Quinquefolii etc. have the excited Pituitary Adrenal cortex hormone function that regulates; Cornu Cervi Pantotrichum, Semen Cuscutae, Fructus Cnidii, Hippocampus, Gecko, Testis et penis callorhini, the Radix Astragali etc. have adjusting hypophysis-gonad function.
Blood stasis causes of senescence is thought: along with organismic age increases, and vital qi degradation, QI-blood circulation slows down, and causes the stagnation of QI, and the stagnation of QI and can not promoting the circulation of blood causes blood stasis, has more hindered the promotion of QI and blood, and QI and blood is not filled, and accelerates old and feeble.Blood-activating and stasis-removing, by enhancing human body immunity function, suppresses the activity of body oxygen-derived free radicals, reduces peroxide and generates and activate oxidasic effect; By improving in blood vessel blood stasis situation and vessel wall elasticity, improve body microcirculation and play anti-aging effects.There is research to point out that Oletum Trogopterori, Rhizoma Corydalis, Rhizoma Chuanxiong can obviously improve and exempt from AMLS (ALS) model mice T lymphocyte transformation function; Radix Paeoniae Rubra and Rhizoma Chuanxiong can obviously improve the activity of plain II (IL-3) that be situated between between ALS murine interleukin; Cortex Moutan can make ALS model mice B pouring turn value and the active decline of NK.The effect of the single Mc phagocytic functions that are improved such as Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Flos Carthami, Radix Paeoniae Rubra, Rhizoma Curcumae.The superoxide anion that 7 kinds of water soluble ingredients of Radix Salviae Miltiorrhizae produce xanthine xanthine oxidase system all has obvious scavenging action.Ginsenoside Rb in Radix Notoginseng
1and Rg
1it is the antioxidant of natural high-quality.Radix Paeoniae Rubra can reduce Lipoperoxide thing (LPO).It is active that Rhizoma Chuanxiong can increase blood SOD, suppresses LDH and MDA content and rise.
The mankind sick, old,, be extremely irresistible trend, but method and the approach of controlling aging course are found in the generation of slow down aging, explore old and feeble mechanism, are the targets that people pursue always.Have in the market some anti-aging products, as tea polyphenols, grape seed extract OPC, Folium Ginkgo extract, soybean phospholipid, spirulina plalensis and vitamin E etc., these products have certain curative effect aspect defying age, but it is single usually to fill a prescription, and acts on not comprehensive.
The present invention is compatible by Fructus Ligustri Lucidi, Herba Ecliptae, Radix Panacis Quinquefolii, Radix Rehmanniae, Fructus Psoraleae, for causing the factor of declining, from integral body, at many levels, check in many aspects senescence process, by the comprehensive adjusting to body's immunity, improve body Ability of antioxygen free radicals, thereby invigorating qi and benefiting blood reaches the effect that delays body aging, have righting tonify deficiency, the anti-ageing effect that lengthens one's life, suitable vast middle-aged and elderly people is taken.
Three, summary of the invention
Technical scheme of the present invention has been to provide a kind of delay aging drug composition and method of making the same.This Chinese medicine composition is compatible by Fructus Ligustri Lucidi, Herba Ecliptae, Radix Panacis Quinquefolii, Radix Rehmanniae, Fructus Psoraleae, by the comprehensive adjusting to body's immunity, improve Ability of antioxygen free radicals, thereby invigorating qi and benefiting blood reaches the effect that delays body aging, have righting tonify deficiency, the anti-ageing effect that lengthens one's life, suitable vast middle-aged and elderly people is taken.
The present invention is achieved by the following technical solutions.
A delay aging drug compositions, is characterized in that being prepared from by following raw material and weight proportion: 20～60 parts of Fructus Ligustri Lucidi (steaming), 20～60 parts of Herba Ecliptaes, 1～10 part of Radix Panacis Quinquefolii, 10～50 parts of Radix Rehmanniae, 10～80 parts of Radix Salviae Miltiorrhizaes, 10～30 parts of Fructus Psoraleaes.Preferred weight proportioning of the present invention is: 30～50 parts of Fructus Ligustri Lucidi (steaming), 30～50 parts of Herba Ecliptaes, 3～7 parts of Radix Panacis Quinquefoliis, 20～40 parts of Radix Rehmanniae, 20～65 parts of Radix Salviae Miltiorrhizaes, 15～25 parts of Fructus Psoraleaes.
Chinese medicine composition as above, is characterized in that Radix Rehmanniae can change any in Radix Angelicae Sinensis, Radix Polygoni Multiflori, the Radix Paeoniae Alba, Colla Corii Asini, Arillus Longan into; Radix Salviae Miltiorrhizae can change any in Rhizoma Chuanxiong, Radix Notoginseng, Radix Paeoniae Rubra, Rhizoma Curcumae, Semen Persicae into; Fructus Psoraleae can change any in Radix Morindae Officinalis, Rhizoma Curculiginis, Herba Epimedii, Herba Cistanches, Cordyceps, the Cortex Eucommiae, Cornu Cervi Pantotrichum, Semen Cuscutae into.
Chinese medicine composition as above, the source that it is characterized in that described raw material can be Chinese crude drug or the extract that is equivalent to Chinese crude drug crude drug amount.
A kind of delay aging drug compositions, it is characterized in that preparation method is that the Fructus Ligustri Lucidi powder steaming is broken into fine powder is standby, other Chinese medicine in formula is decocted with water to secondary, add for the first time 8～15 times of water, add for the second time 10～12 times of water, each decoction 1～3 hour, filter, filtrate is condensed into thick paste, mixes with Fructus Ligustri Lucidi fine powder, granulate, obtain.
The preparation method of Chinese medicine composition as above, is characterized in that finished dosage forms can be granule, tablet, hard capsule, soft capsule, drop pill, pill, extractum or the oral liquid that adopts pharmaceutically acceptable carrier or excipient to make by pharmaceutics common process.
Chinese medicine composition as above, is characterized in that preparing the application in antidotal medicine or health product.
Pharmacodynamic study is found, Chinese medicine composition gastric infusion of the present invention can obviously increase mouse immune organ weight and Phagocytosis By The Peritoneal Macrophages In Mice, promote mice hemolytic antibody to generate, acetylphenylhydrazine is caused to Mouse Blood virtual model and have remarkable therapeutical effect, can make the content of SOD, GSH-Px in D-galactose institute Aging mice brain, nephridial tissue raise, MDA content reduces, and shows that this product has righting tonify deficiency, the anti-ageing effect of lengthening one's life.
Pharmacodynamic study experimental technique and result are as follows:
1 experiment material
1.1 laboratory animal
Kunming mouse, body weight 18～22g, SPF level, is provided by University Of Nanchang's Experimental Animal Center, the animal quality certification number: No. 2009A063.
1.2 experimental drugs and reagent
Delay aging drug compositions is prepared from by Fructus Ligustri Lucidi (steaming), Herba Ecliptae, Radix Panacis Quinquefolii, Radix Rehmanniae, Radix Salviae Miltiorrhizae, Fructus Psoraleae.Cyclophosphamide injectable powder (Hengrui Medicine Co., Ltd., Jiangsu Prov.; lot number: 100511; specification: 200mg/ props up, CTX), levamisole hydrochloride tablets (Shandong Province Hong Nan pharmaceutical factory; lot number: 100601; specification: 25mg/ sheet, LHT), 2; 4-dinitrochlorobenzene, Solution on Chemical Reagents in Shanghai one factory.Acetone, Solution on Chemical Reagents in Shanghai company limited.
1.3 instrument
Japan Shimadzu EB-3200D-AW electronic balance, Japanese Shimadzu UV-730 automatic biochemical colour comparatour, optical instrument factory, Chongqing, mice diving tower instrument, stopwatch, thermostatic water tank.
2 experimental techniques and result
2.1 impacts on the low mouse immune organ weight of CTX immunogenicity
Get 48 of healthy Kunming mouses, male and female half and half, are divided into 4 groups at random by body weight, 12 every group.Each administration treated animal gastric infusion 20mL/kg, every day 1 time, blank group and model group gavage equivalent distilled water, continuously 7d.Administration the 2nd day, except normal group, all the other respectively organize subcutaneous injection CTX 40ms/kg, continuously 3d.2h after art time administration, weighs, and de-cervical vertebra execution mice, wins thymus and spleen is weighed, and calculates thymus, index and spleen index.The results are shown in Table 1.
The impact of table 1 on the low mouse immune organ weight of CTX immunogenicity
| Group | Dosage (g crude drug/kg) | Thymus index (mg/g) | Index and spleen index (mg/g) |
| Blank group | - | 2.77±0.62 | 3.89±0.92 |
| Model group | - | 1.09±0.58△ | 1.99±0.61△ |
| Chinese medicine composition group | 12 | 1.96±0.69** | 3.96±0.82** |
| Chinese medicine composition group | 18 | 1.89±0.55** | 3.75±0.77** |
Note: with the comparison of blank group, △ P < 0.01; With model group comparison, * P < 0.05, * * P < 0.01.
As can be seen from Table 1: can raise the to some extent Thymus and Spleen index of the low mice of CTX immunogenicity of Chinese medicine composition group, with model group comparison, all has significance or utmost point significant difference (P < 0.01).
2.2 impacts on the low Phagocytosis By The Peritoneal Macrophages In Mice of CTX immunogenicity
Get 48 of healthy Kunming mouses, male and female half and half, by 2.1 lower method groupings, administration, modeling.Administration the 7th day, every Mus lumbar injection 5% chicken red blood cell normal saline suspension 0.2mL/10g, after injection chicken red blood cell 6h and last administration 2h, de-cervical vertebra is put to death mice, disinfect skin of abdomen in alcohol, lumbar injection Hank ' S liquid 2.5mL, gently rub mouse web portion, on peritoneum, cut an aperture, after sucking-off peritoneal fluid, drip a little at microscope slide push jack, dry rear Wright's stain dyeing, tap water rinses, dry, micro-Microscopic observation, calculates Turnover of Mouse Peritoneal Macrophages to the phagocytic percentage of chicken red blood cell and phagocytic index.The results are shown in Table 2.
The impact of table 2 on the low Phagocytosis By The Peritoneal Macrophages In Mice of CTX immunogenicity
| Group | Dosage (g crude drug/kg) | Phagocytic percentage (%) | Phagocytic index |
| Blank group | - | 65.21±5.62 | 0.71±0.12 |
| Model group | - | 40.09±3.58△ | 0.39±0.11△ |
| Chinese medicine composition group | 12 | 53.96±4.69** | 0.66±0.12** |
| Chinese medicine composition group | 18 | 51.89±4.58** | 0.58±0.13** |
Note: with the comparison of blank group, △ P < 0.01; With model group comparison, * P < 0.05, * * P < 0.01.
As can be seen from Table 2, Chinese medicine composition group all can raise to some extent phagocytic percentage and the phagocytic index of the low Turnover of Mouse Peritoneal Macrophages of CTX immunogenicity, with model group comparison, all there is significance or utmost point significant difference (P < 0.05 or P < 0.01).
2.3 impacts on the low mice serum hemolysin level of CTX immunogenicity
Get 48 of healthy Kunming mouses, by 2.1 lower method groupings, administration, modeling.Administration the 2nd day, each is organized every mouse peritoneal and injects 5% chicken red blood cell normal saline suspension 0.2mL immunity.2h after last administration, eye socket venous blood collection, centrifuging and taking serum, with normal saline, by 100 times of serum dilutions, get dilute serum 1mL and mix with 5% chicken red blood cell suspension 0.5mL, 10% complement serum 0.5mL, 37 ℃ of constant-temperature incubation 30min, cessation reaction in 0 ℃ of refrigerator, centrifuging and taking supernatant, ultraviolet spectrophotometer 540nm surveys absorbance OD value, with the blank pipe supernatant of increase serum not, compares.The results are shown in Table 3.
The impact of table 3 on the low mice serum hemolysin level of CTX immunogenicity
| Group | Dosage (g crude drug/kg) | Serum hemolysin (OD value) |
| Blank group | - | 0.231±0.064 |
| Model group | - | 0.049±0.008△ |
| Chinese medicine composition group | 12 | 0.087±0.038** |
| Chinese medicine composition group | 18 | 0.086±0.033** |
Note: with the comparison of blank group, △ P < 0.01; With model group comparison, * P < 0.05, * * P < 0.01.
As can be seen from Table 3, Chinese medicine composition group all can reduce the low mice serum hemolysin level of CTX immunogenicity to some extent, with model group comparison, there is significance or utmost point significant difference (P < 0.05 or P < 0.01).
2.4 impacts on the low mice delayed hypersensitivity of CTX immunogenicity (DTH)
Get 48 of healthy Kunming mouses, by 2.1 lower method groupings, administration, modeling and immunity, successive administration 11d.Administration the 2nd day, only, interval 2d is with dosage sensitization 1 time again for subcutaneous injection 3%DNCB-acetone soln 0.05mL/.After the 1st sensitization the 10th day, with 1%DNCB-acetone soln 0.02mL, be applied to auris dextra and attack, left ear compares, and puts to death animal after 24h, with 9mm diameter card punch, lay the round auricle at the same position of ears and weigh, calculate ear swelling degree (left and right auricle weight poor).The results are shown in Table 4
The impact of table 4 on the low mice delayed hypersensitivity of CTX immunogenicity (DTH)
| Group | Dosage (g crude drug/kg) | Ear swelling degree (mg) |
| Blank group | - | 3.93±1.04 |
| Model group | - | 2.07±0.88△ |
| 1 group of Chinese medicine composition | 12 | 3.47±1.02** |
| 2 groups of Chinese medicine compositions | 18 | 3.36±0.93** |
Note: with the comparison of blank group, △ P < 0.01; With model group comparison, * P < 0.05, * * P < 0.01.
As can be seen from Table 4, each administration group all can improve the low mice ear degree of CTX immunogenicity to some extent, with model group comparison, has significance or utmost point significant difference (P < 0.05 or P < 0.01).
2.5 impacts on the low mouse peripheral blood T of CTX immunogenicity lymphocyte percentage
Get 48 of healthy Kunming mouses, by 2.1 lower method groupings, administration, modeling and immunity.1h after last administration, eye socket venous blood sampling push jack.After drying, 37qC constant-temperature incubation 3h, tap water rinses sediment, and filter paper is inhaled in the globule, adds 1% malachite green solution and dyes 5-10 second, and tap water rinses, and filter paper is gently inhaled, and dries 100 lymphocytes of rear oily spectroscopy, calculates T lymphocyte percentage.The results are shown in Table 5
The impact of table 5 on the low mouse peripheral blood T of CTX immunogenicity lymphocyte percentage
| Group | Dosage (g crude drug/kg) | T lymphocyte percentage (%) |
| Blank group | - | 69.48±6.40 |
| Model group | - | 38.64±6.12△ |
| Chinese medicine composition group | 12 | 47.55±5.02** |
| Chinese medicine composition group | 18 | 46.87±5.83** |
Note: with the comparison of blank group, △ P < 0.01; With model group comparison, * P < 0.05, * * P < 0.01.
As can be seen from Table 5, the Chinese medicine composition group low mouse peripheral blood T of the CTX immunogenicity lymphocyte percentage that all can raise to some extent, with model group comparison, there is significance or utmost point significant difference (P < 0.05 or P < 0.01).
2.6 cause the impact of Mouse Blood virtual model to acetylphenylhydrazine
Get 48 of healthy Kunming mouses, male and female half and half, are divided into 4 groups at random by body weight.Be blank group, model group, Chinese medicine composition high and low dose group.Test the 1st, 4,7 days, to mice difference subcutaneous injection 2% acetylphenylhydrazine 0.1,0.05,0.05ml/10g (blank group injection isometric(al) normal saline).From testing, within the 1st day, start gastric infusion, once a day, continuous 10 days, eye socket blood sampling in the 11st day, by cyaniding high ferro spectrophotometry hemoglobin (Hb), with turbidimetry for Determination erythrocyte (RBC) number, the results are shown in Table 6.
The impact of table 6 on blood deficiency mouse peripheral blood Hb, RBC
| Group | Dosage (g crude drug/kg) | Hb(g/L) | RBC(/L) |
| Blank group | - | 165.21±5.62 | 0.71±0.12 |
| Model group | - | 92.01±8.75△ | 0.39±0.11△ |
| 1 group of Chinese medicine composition | 12 | 53.96±4.69** | 0.66±0.12** |
| 2 groups of Chinese medicine compositions | 18 | 51.89±4.58** | 0.58±0.13** |
Note: with the comparison of blank group, △ P < 0.01; With model group comparison, * P < 0.05, * * P < 0.01.
As known from Table 6, model of blood dificiency group mice Hb and RBC, all significantly lower than normal group, show modeling success.Take after Chinese medicine composition, blood deficiency mice periphery Hb, RBC are significantly increased, and have compared significant difference (P < 0.01) with model group.
2.7 cause the impact of aging model mice to D-galactose
Get 48 of healthy Kunming mouses, male and female half and half, are divided into 4 groups at random by body weight.Be blank group, model group, Chinese medicine composition high and low dose group.Model group and Chinese medicine composition group mice cervical region every day subcutaneous injection 5%D-galactose 0.5ml/, continuous surrounding, blank group subcutaneous injection equal-volume normal saline.At injection of d-galactose, started gastric infusion the same day, every day 1 time, altogether surrounding.When experiment finishes, by diving tower method, measure learning and memory of little mouse situation, then with dislocation method, put to death white mice, get respectively and in the brain, nephridial tissue ice bath of mice, clean that to be prepared into tissue homogenate cold preservation standby.The results are shown in Table 7,8,9.
Table 7 causes the impact of mouse memory acquired disturbance on D-galactose
Note: with the comparison of blank group, △ P < 0.01; With model group comparison, * P < 0.05, * * P < 0.01.
Table 8 is on respectively organizing the impact of SOD, MDA in mouse brain tissue, GSH-Px level
Note: with the comparison of blank group, △ P < 0.01; With model group comparison, * P < 0.05, * * P < 0.01.
Table 9 is on respectively organizing the impact of SOD, MDA in mouse kidney tissue, GSH-Px level
Note: with the comparison of blank group, △ P < 0.01; With model group comparison, * P < 0.05, * * P < 0.01.
From table 7,8,9, the modeling of aging model mice is after 4 weeks, movable minimizing, is slow in action, and fur is fluffy, shorten its incubation period of getting an electric shock, test errors number of times increases, and the SOD in model group mouse brain, nephridial tissue, GSH-Px level reduce, and MDA level raises, compare with blank group, have significant difference.Chinese medicine composition can make subacute aging model mice electric shock prolongation of latency, and test errors number of times reduces, and the content of SOD, GSH-Px in brain, nephridial tissue raises, and MDA content reduces, and comparing with model group, there were significant differences.
Four, the specific embodiment
With specific embodiment, the present invention is elaborated below:
Embodiment 1:
By following weight proportion, take raw material: 25 parts of Fructus Ligustri Lucidi (steaming), 25 parts of Herba Ecliptaes, 3 parts of Radix Panacis Quinquefoliis, 12 parts of Radix Rehmanniae, 16 parts of Radix Salviae Miltiorrhizaes, 11 parts of Fructus Psoraleaes.
Preparation method: Fructus Ligustri Lucidi (steaming) is ground into fine powder standby, Herba Ecliptae, Radix Panacis Quinquefolii, Radix Rehmanniae, Radix Salviae Miltiorrhizae, Fructus Psoraleae are decocted with water to secondary, add for the first time 15 times of water, decoct 2 hours, add for the second time 12 times of water, decoct 1.5 hours, filter, filtrate is condensed into thick paste, mix with Fructus Ligustri Lucidi fine powder, granulate, tabletting, obtains tablet.
The preparation method of Chinese medicine composition as above, is characterized in that finished dosage forms can be granule, tablet, hard capsule, soft capsule, drop pill, pill, extractum or the oral liquid that adopts pharmaceutically acceptable carrier or excipient to make by pharmaceutics common process.
Embodiment 2:
By following weight proportion, take raw material: 58 parts of Fructus Ligustri Lucidi (steaming), 58 parts of Herba Ecliptaes, 8 parts of Radix Panacis Quinquefoliis, 45 parts of Radix Rehmanniae, 70 parts of Radix Salviae Miltiorrhizaes, 26 parts of Fructus Psoraleaes.
Preparation method: Fructus Ligustri Lucidi (steaming) is ground into fine powder standby, Herba Ecliptae, Radix Panacis Quinquefolii, Radix Rehmanniae, Radix Salviae Miltiorrhizae, Fructus Psoraleae are decocted with water to secondary, add for the first time 12 times of water, add for the second time 10 times of water, decoct 2 hours at every turn, filter, filtrate is condensed into thick paste, mix with Fructus Ligustri Lucidi fine powder, granulate, obtain granule.
The preparation method of Chinese medicine composition as above, is characterized in that finished dosage forms can be granule, tablet, hard capsule, soft capsule, drop pill, pill, extractum or the oral liquid that adopts pharmaceutically acceptable carrier or excipient to make by pharmaceutics common process.
Embodiment 3:
By following weight proportion, take raw material: 32 parts of Fructus Ligustri Lucidi (steaming), 32 parts of Herba Ecliptaes, 4 parts of Radix Panacis Quinquefoliis, 22 parts of Radix Rehmanniae, 21 parts of Radix Salviae Miltiorrhizaes, 16 parts of Fructus Psoraleaes.
Preparation method: Fructus Ligustri Lucidi (steaming) is ground into fine powder standby, Herba Ecliptae, Radix Panacis Quinquefolii, Radix Rehmanniae, Radix Salviae Miltiorrhizae, Fructus Psoraleae are decocted with water to secondary, add for the first time 15 times of water, add for the second time 12 times of water, extract 2 hours at every turn, filter, filtrate is condensed into thick paste, and vacuum drying gets dry extract, be ground into fine powder, after mixing with Fructus Ligustri Lucidi fine powder, high temperature sterilize, under aseptic condition, pack hard capsule into, obtain.
The preparation method of Chinese medicine composition as above, is characterized in that finished dosage forms can be granule, tablet, hard capsule, soft capsule, drop pill, pill, extractum or the oral liquid that adopts pharmaceutically acceptable carrier or excipient to make by pharmaceutics common process.
Embodiment 4:
By following weight proportion, take raw material: 48 parts of Fructus Ligustri Lucidi (steaming), 48 parts of Herba Ecliptaes, 7 parts of Radix Panacis Quinquefoliis, 38 parts of Radix Rehmanniae, 62 parts of Radix Salviae Miltiorrhizaes, 24 parts of Fructus Psoraleaes.
Preparation method: Fructus Ligustri Lucidi (steaming) is ground into fine powder standby, by Herba Ecliptae, Radix Panacis Quinquefolii, Radix Rehmanniae, Radix Salviae Miltiorrhizae and Fructus Psoraleae extracting in water secondary, add for the first time 15 times of water, extract 3 hours, add for the second time 12 times of water, extract 2 hours, filter, filtrate is condensed into thick paste, adds 50 parts of refined honeys and mixes with Fructus Ligustri Lucidi fine powder, pill, obtains pill.
The preparation method of Chinese medicine composition as above, is characterized in that finished dosage forms can be granule, tablet, hard capsule, soft capsule, drop pill, pill, extractum or the oral liquid that adopts pharmaceutically acceptable carrier or excipient to make by pharmaceutics common process.
Embodiment 5:
By following weight proportion, take raw material: 40 parts of Fructus Ligustri Lucidi (steaming), 40 parts of Herba Ecliptaes, 5 parts of Radix Panacis Quinquefoliis, 30 parts of Radix Rehmanniae, 45 parts of Radix Salviae Miltiorrhizaes, 20 parts of Fructus Psoraleaes.
Preparation method: Fructus Ligustri Lucidi (steaming) is ground into fine powder standby, Herba Ecliptae, Radix Panacis Quinquefolii, Radix Rehmanniae, Radix Salviae Miltiorrhizae, Fructus Psoraleae are decocted with water to secondary, add for the first time 12 times of water, add for the second time 10 times of water, decoct 2 hours at every turn, filter, filtrate is condensed into thick paste, mix with Fructus Ligustri Lucidi fine powder, granulate, obtain granule.
The preparation method of Chinese medicine composition as above, is characterized in that finished dosage forms can be granule, tablet, hard capsule, soft capsule, drop pill, pill, extractum or the oral liquid that adopts pharmaceutically acceptable carrier or excipient to make by pharmaceutics common process.
Embodiment 6:
By following weight proportion, take raw material: 32 parts of Fructus Ligustri Lucidi (steaming), 32 parts of Herba Ecliptaes, 4 parts of Radix Panacis Quinquefoliis, 22 parts of Radix Rehmanniae, 21 parts of Radix Salviae Miltiorrhizaes, 16 parts of Fructus Psoraleaes.
Preparation method: Fructus Ligustri Lucidi (steaming) is ground into fine powder standby, Herba Ecliptae, Radix Panacis Quinquefolii, Radix Rehmanniae, Radix Salviae Miltiorrhizae, Fructus Psoraleae are decocted with water to secondary, add for the first time 15 times of water, add for the second time 12 times of water, extract 2 hours at every turn, filter, filtrate is condensed into thick paste, and vacuum drying gets dry extract, be ground into fine powder, after mixing with Fructus Ligustri Lucidi fine powder, high temperature sterilize, under aseptic condition, pack hard capsule into, obtain.
In raw material as above, Radix Rehmanniae can change any in Radix Angelicae Sinensis, Radix Polygoni Multiflori, the Radix Paeoniae Alba, Colla Corii Asini, Arillus Longan into.
The preparation method of Chinese medicine composition as above, is characterized in that finished dosage forms can be granule, tablet, hard capsule, soft capsule, drop pill, pill, extractum or the oral liquid that adopts pharmaceutically acceptable carrier or excipient to make by pharmaceutics common process.
Embodiment 7:
By following weight proportion, take raw material: 48 parts of Fructus Ligustri Lucidi (steaming), 48 parts of Herba Ecliptaes, 7 parts of Radix Panacis Quinquefoliis, 38 parts of Radix Rehmanniae, 62 parts of Radix Salviae Miltiorrhizaes, 24 parts of Fructus Psoraleaes.
Preparation method: Fructus Ligustri Lucidi (steaming) is ground into fine powder standby, by Herba Ecliptae, Radix Panacis Quinquefolii, Radix Rehmanniae, Radix Salviae Miltiorrhizae, Fructus Psoraleae extracting in water secondary, add for the first time 15 times of water, extract 3 hours, add for the second time 12 times of water, extract 2 hours, filter, filtrate is condensed into thick paste, adds 50 parts of refined honeys and mixes with Fructus Ligustri Lucidi fine powder, pill, obtains pill.
In raw material as above, Fructus Psoraleae can change any in Radix Morindae Officinalis, Rhizoma Curculiginis, Herba Epimedii, Herba Cistanches, Cordyceps, the Cortex Eucommiae, Cornu Cervi Pantotrichum, Semen Cuscutae into.
The preparation method of Chinese medicine composition as above, is characterized in that finished dosage forms can be granule, tablet, hard capsule, soft capsule, drop pill, pill, extractum or the oral liquid that adopts pharmaceutically acceptable carrier or excipient to make by pharmaceutics common process.
Embodiment 8:
By following weight proportion, take raw material: 58 parts of Fructus Ligustri Lucidi (steaming), 58 parts of Herba Ecliptaes, 8 parts of Radix Panacis Quinquefoliis, 45 parts of Radix Rehmanniae, 70 parts of Radix Salviae Miltiorrhizaes, 26 parts of Fructus Psoraleaes.
Preparation method: Fructus Ligustri Lucidi (steaming) is ground into fine powder standby, Herba Ecliptae, Radix Panacis Quinquefolii, Radix Rehmanniae, Radix Salviae Miltiorrhizae, Fructus Psoraleae are decocted with water to secondary, add for the first time 12 times of water, add for the second time 10 times of water, decoct 2 hours at every turn, filter, filtrate is condensed into thick paste, mix with Fructus Ligustri Lucidi fine powder, granulate, obtain granule.
In raw material as above, Radix Salviae Miltiorrhizae can change any in Rhizoma Chuanxiong, Radix Notoginseng, Radix Paeoniae Rubra, Rhizoma Curcumae, Semen Persicae into.
The preparation method of Chinese medicine composition as above, is characterized in that finished dosage forms can be granule, tablet, hard capsule, soft capsule, drop pill, pill, extractum or the oral liquid that adopts pharmaceutically acceptable carrier or excipient to make by pharmaceutics common process.
Claims (4)
1. a delay aging drug compositions, is characterized in that being prepared from by following raw material and weight proportion: 20～60 parts of Fructus Ligustri Lucidi, 20～60 parts of Herba Ecliptaes, 1～10 part of Radix Panacis Quinquefolii, 10～50 parts of Radix Rehmanniae, 10～80 parts of Radix Salviae Miltiorrhizaes, 10～30 parts of Fructus Psoraleaes; During preparation, Fructus Ligustri Lucidi powder is broken into fine powder standby, other Chinese medicine in formula is decocted with water to secondary, add for the first time 8～15 times of water, add for the second time 10～12 times of water, each extraction 1～3 hour, filters, and filtrate is condensed into thick paste, mix with Fructus Ligustri Lucidi fine powder, granulate, obtain.
2. Chinese medicine composition as claimed in claim 1, wherein the weight proportion of each raw material is: 30～50 parts of Fructus Ligustri Lucidi, 30～50 parts of Herba Ecliptaes, 3～7 parts of Radix Panacis Quinquefoliis, 20～40 parts of Radix Rehmanniae, 20～65 parts of Radix Salviae Miltiorrhizaes, 15～25 parts of Fructus Psoraleaes; During preparation, Fructus Ligustri Lucidi powder is broken into fine powder standby, other Chinese medicine in formula is decocted with water to secondary, add for the first time 8～15 times of water, add for the second time 10～12 times of water, each extraction 1～3 hour, filters, and filtrate is condensed into thick paste, mix with Fructus Ligustri Lucidi fine powder, granulate, obtain.
3. Chinese medicine composition as claimed in claim 1 or 2, is characterized in that dosage form is granule, tablet, hard capsule, soft capsule, pill, extractum or the oral liquid that adopts pharmaceutically acceptable carrier or excipient to make by pharmaceutics common process.
4. the application of Chinese medicine composition as claimed in claim 1 or 2 in the antidotal medicine of preparation or health product.
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| CN106138427A (en) * | 2015-03-31 | 2016-11-23 | 北京海吉星医疗科技有限公司 | A kind of antioxidation, the Chinese medicine composition of defying age |
| CN104857196A (en) * | 2015-06-11 | 2015-08-26 | 杨明德 | Traditional Chinese medicine preparation for treating epidural anesthesia nerve injuries |
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| CN1273842A (en) * | 2000-04-22 | 2000-11-22 | 丁晓虎 | Multi-nutrient instant particles for refreshing brain, loosing weight, making bone stronger, blackening hair and elongating life |
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| CN102579757A (en) * | 2012-03-27 | 2012-07-18 | 山东中医药大学 | Anti-aging Chinese medicine composition in separation medicine and moxibustion umbilicus mode |
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| CN1634293A (en) * | 2004-09-24 | 2005-07-06 | 叶耀良 | 'Xianlinggubao' new preparation, its preparing method and application |
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