CN107088215A - A kind of herbaceous plant solid beverage of relieving insomnia symptom and preparation method thereof - Google Patents
A kind of herbaceous plant solid beverage of relieving insomnia symptom and preparation method thereof Download PDFInfo
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- CN107088215A CN107088215A CN201710228288.1A CN201710228288A CN107088215A CN 107088215 A CN107088215 A CN 107088215A CN 201710228288 A CN201710228288 A CN 201710228288A CN 107088215 A CN107088215 A CN 107088215A
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
- A23L2/395—Dry compositions in a particular shape or form
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/738—Rosa (rose)
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
It is the invention discloses a kind of herbaceous plant solid beverage of relieving insomnia symptom and preparation method thereof-active compound composition and weight proportion：25 40 grams of wheat, 35 grams of radix glycyrrhizae, 9 15 grams of jujube, 9 15 grams of lily, 9 15 grams of spina date seed, 9 15 grams of Chinese yam, 9 15 grams of Poria cocos, 9 15 grams of longan, 9 15 grams of rose；The patent medicine of the herbaceous plant solid beverage is constituted and weight proportion is：3 grams of wheat, 0.3 gram of radix glycyrrhizae, 1 gram of jujube, 1 gram of lily, 1 gram of spina date seed, 1 gram of Chinese yam, 1 gram of Poria cocos, 1 gram of longan, 1 gram of rose.The present invention is using the herbal raw material of pure Chinese medicine, it then follows " monarch ", " minister ", " assistant ", " making " principle, with wheat, spina date seed altogether for monarch, with radix glycyrrhizae, Poria cocos altogether for minister, using jujube as assistant, using radix glycyrrhizae to make, it is subject to lily, Chinese yam, longan, rose, all medicines share, nourishing in sweet flavor, clearing heat and relieving fidgetness, stress of releiving is put forth effort on, antianxiety, solution is depressed, without dependence, have no toxic side effect.
Description
Technical field
The present invention relates to a kind of herbaceous plant solid beverage of relieving insomnia symptom and preparation method thereof.
Background technology
Rapid development of economy, the work of compatriots, study, life stress are increasing, and physical condition goes from bad to worse,
Mental status increasingly nervous anxiety, sleep quality problem threatens our health subtlely.
Scientific investigations showed that, sleep is physiological phenomenon and mental process necessary to human life activity, and sleep quality is
One people's health quality it is basic.One people does not have good sleep quality, it is then not possible to the body possessed.During sleep
Between it is irregular, sleep-disorder can influence the secretion of hormone in vivo, and if things go on like this variety of diseases all can be with, be good in sub-
The people of health situation is close to seventy percent.Insomnia is can not often to obtain the class illness that ortho is characterized.The lighter's difficulty falling asleep, or
Sleep but not soundly, sometimes sleeping and sometimes waking, or can not sleep again after waking up, it is heavy then be insomnia all night.Insomnia is one of common clinical disease, though it is not belonging to
Critical illness, from the perspective of short-term, what sleep insufficiency was directly affected is the work and study of second day, can cause people's tired
Labor sense, uneasiness, general malaise, listless, delay of response, headache, notice can not be concentrated；From the point of long-term development, endanger
Evil is even more huge and far-reaching：In terms of maximum effect is spirit, Most patients chronic insomnia, more sleepy more be can't fall asleep, more
It is anxious can not sleep any more more, easily trigger anxiety disorder；Insomnia simultaneously is all the possibility for inducing certain potential disease, such as essence for many people
God's division and depression, anxiety disorder, vegetative dystonia, it is hyperfunction etc. to be susceptible to suffer from nervous function, trick heart hidrosis, the heart occurs
Throb with fear, rapid heart beat, the anxious resistance of breathing, contraction of muscle is trembled, and urgent urination frequent micturition, chest has constriction, abdominal distension and rushed down, pharyngeal to hinder to feel, many
Sweat, four limbs do not have the symptoms such as power numbness and each systemic disease, such as cardiovascular system, digestive system；The society having a sleepless night to people
Can property will also result in great harm, due to be absorbed in for a long time the worry for sleep with it is panic in, people can become it is suspicious, sensitive,
Irritability, and suitable self-doubt, the interpersonal relationships of each side during these certainly will influence it in family and work, so as to produce
Feeling of lonely, sense of defeat.
Over the past thousands of years, our generations use the wisdom traditional Chinese medicine of the sage of the past.Exactly traditional Chinese medicine protects our people
The health of race, makes we are national to multiply from generation to generation, life and growth in nature.The traditional Chinese medical science thinks the insomnia cause of disease in the heart, and the sleep of people is by mind control
System.The heart further relates to how dirty liver, spleen, stomach, kidney be, and the normal operation of all dirty functions and coordination, the operation of the gas of yin-Yang are also normal,
Then the sleep of people is normal.Conversely, abnormal emotion, think of of overworking cause it is confused and worried, have ants in one's pants, sun do not enter it is cloudy, can not be by moving
Turn quiet entrance sleep state, sleep-disorder just occurs, with induced insomnia.Traditional Chinese medicine is far-reaching and rich to the discussion source stream of insomnia
It is rich.《The Yellow Emperor's Canon of Internal Medicine》In be referred to as " mesh not eye ", " must not sleep ", " must not nourish ".《The Yellow Emperor's Canon of Internal Medicine Plain Questions》Describe the disease of insomnia
Cause and treatment.《The Yellow Emperor's Canon of Internal Medicine Ling Shu Miraculous Pivot or Divine Axis》The physiological mechanism of sleep and the pathomechanism of insomnia has been discussed in detail.《The Yellow Emperor's Canon of Internal Medicine》
It is that traditional Chinese medicine debates the origin for controlling insomnia, the opinion that it is established controls the clinical practice that principle also instructs later age always.《In Yellow Emperor, a legendary ruler
Through》Think that sleep is relevant with defending gas, battalion's the moon, yinqiao channel, yangqiao meridian.Such as《The big puzzled opinions of Ling Shu Miraculous Pivot or Divine Axis》Middle theory：" Fu Wei gas persons, day
Often, go in sun, go out walking in the night in the moon, therefore yang-energy then crouches to the greatest extent, cloudy gas then ruffian to the greatest extent ".Defending the operation of gas has rules different round the clock, so people
Body also has the rhythm and pace of moving things slept at awake night in daytime.If human body defends gas and runs the rhythm and pace of moving things round the clock and gets muddled, it may result in and sleep or be insomnia less.And its
His illness, such as cough, vomiting, distention and fullness in the abdomen can also influence sleep.Such as《Plain Questions, it is inverse to adjust opinion》In just have " disorder of the stomach leading to insomnia with restlessness "
Viewpoint.《The Yellow Emperor's Canon of Internal Medicine》Emphasize that overabundance of YANG leading to deficiency of YIN or battalion defend operation and become estranged as the Etiological of insomnia.Therefore, harmonizing yingfen and weifen, is adjusted
Negative and positive actual situation, strengthening vital QI to eliminate pathogenic factors is the Important Rule for the treatment of insomnia.
At present, the medicine of clinical treatment insomnia is many application Western medicine sedatives to benumb based on nervous system, is such as pacified
The phenobarbital class medicines such as fixed, surazepam, Alprazolam, clonazepam, fludiazepam, make one sleep state occur.However,
All such medicines are that, by human kidney, hepatic excretion, and it can not be drained totally completely every time, and long-term accumulation can go out
Perception declines, makes situations such as liver, kidney device are damaged after existing excess sedation.This, which is also why patient is used for a long time, helps sleep class
Through often there is the phenomenon such as dizzy, headache lassitude without reason after medicine, the equivalent Chronic Suicide of sleeping class Western medicine is eaten for a long time.Chinese medicine can
To avoid the appearance of this case, pure herbaceous plant is naturally safe, natural can be excreted safely with the excreta of human body.Take
The insomniac of sleeping class Western medicine is crossed, can find that in drug administration sleep is to ensure, but be once discontinued will be according to
Old insomnia, or even there is the situation that insomnia is aggravated, this is the addicted side effect of Western medicine.Chinese medicine is avoided that such phenomenon, and this is
Started with due to Chinese medicine with nursing one's health the overall equilibrium between yin and yang cause of disease of human body, cured pathogenic factor, rebound phenomenon would not occur in drug withdrawal.
As economy is continued to develop, the expansion in consumer demand face, at present, the study hotspot of solid beverage are mainly
The exploitation of compound function solid beverage.Such as application for a patent for invention " a kind of beverage for treating neurasthenia aypnia "（Patent Shen
Please number：201510558782.5）A kind of beverage for including telegraph plant, oriental dodartia herb, semen astragali complanati etc. is disclosed, can nourishing Yin and moistening dryness, blood-nourishing
Relieve dizziness, high fever, infantile convulsions, epilepsy, etc., qi and activate blood circulation, strengthening vital QI to eliminate pathogenic factors, all medicines coordinate, and have preferable therapeutic effect to neurasthenia aypnia；Application for a patent for invention
" the anti-insomnia alternative tea that a kind of use food plant is made as composition "（Number of patent application：20151028353.2）Disclose
The anti-insomnia alternative tea that a kind of use food plant is made as composition, by spina date seed, matrimony vine, Chinese yam, Poria cocos, donkey-hide gelatin, white flat
Beans, lily, arillus longan, jujube, Buddha's hand, radix glycyrrhizae are made, and can adjust each organ function of human body, and anaemia, neurasthenia etc. are had a sleepless night
Person is effective.Application for a patent for invention " a kind of evodia rutaecarpa beverage of suppression insomnia "（Number of patent application：201410638650.9）It is public
A kind of beverage for containing the compositions such as evodia rutaecarpa, scutellaria, spina date seed has been opened, had effects that to improve sleep quality, solve insomnia.
Application for a patent for invention " dedicated for the formula of herbal tea of conditioning insomnia "（Number of patent application：201410402790.6）Disclose one kind
The herbal tea being made up of Huai wheat, radix glycyrrhizae, jujube, spina date seed, chrysanthemum, Sang mulberrys, the fruit of Chinese wolfberry, Zhu's cornus, the fruit of Chinese magnoliavine, longan, hawthorn,
There is conditioning insomnia.The solid beverage of safety and health is produced, helps compatriots to possess high-quality deep sleep, does not have again
There is side effect, equally allow compatriots to embrace health, this is being currently owned by wide industrial prospect.
The content of the invention
It is an object of the invention to：A kind of herbaceous plant solid beverage of relieving insomnia symptom and preparation method thereof is provided.
The present invention formed by Chinese herbal medicine reasonable preparation, available for improve sleep quality, relieving insomnia symptom, treatment anxiety disorder, depression,
Sleep-disorder caused by stress, bad life habits；Anxiety, depression, headache, the heart caused by climacteric metancholia of releiving
Tired, uncomfortable in chest, insomnia and dreamful sleep symptom；Antitoxic heart-soothing and sedative, help mitigation examination before pressure, improve biotonus；It is neurasthenic
Auxiliary treatment, and need to change the personage of daily life system in the short time, such as：Environmental change, the safety such as get jet lag are adapted to without pair
Effect, is worth of widely use.
Various raw material used in the present invention can be all commercially available from a medical store, and its specification meets country or industry mark
Standard.
The present invention is achieved by the following technical solutions：A kind of herbaceous plant solid beverage of relieving insomnia symptom, with
Active compound meter, includes the component of following weight proportion：25-40 grams of wheat, 3-5 grams of radix glycyrrhizae, 9-15 grams of jujube, 9-15 grams of lily, acid
9-15 grams of jujube kernel, 9-15 grams of Chinese yam, 9-15 grams of Poria cocos.
Preferably, the herbaceous plant solid beverage of the relieving insomnia symptom is in terms of active compound, including following weight proportion
Component：30-35 grams of wheat, 3-5 grams of radix glycyrrhizae, 10-12 grams of jujube, 10-12 grams of lily, 10-12 grams of spina date seed, 10-12 grams of Chinese yam,
10-12 grams of Poria cocos.
Preferably, the herbaceous plant solid beverage of the relieving insomnia symptom is in terms of active compound, including following weight proportion
Component：30 grams of wheat, 3 grams of radix glycyrrhizae, 10 grams of jujube, 10 grams of lily, 10 grams of spina date seed, 10 grams of Chinese yam, 10 grams of Poria cocos.
More excellent, the herbaceous plant solid beverage of the relieving insomnia symptom is in terms of patent medicine, including following weight proportion
Component：3 grams of wheat, 0.3 gram of radix glycyrrhizae, 1 gram of jujube, 1 gram of lily, 1 gram of spina date seed, 1 gram of Chinese yam, 1 gram of Poria cocos.
According to above-mentioned technical proposal, the present invention also provides a kind of herbaceous plant solid beverage of above-mentioned relieving insomnia symptom
Preparation method, comprises the following steps：
（1）Take the active compound component of following weight proportion：25-40 grams of wheat, 3-5 grams of radix glycyrrhizae, 9-15 grams of jujube, 9-15 grams of lily,
9-15 grams of spina date seed, 9-15 grams of Chinese yam, 9-15 grams of Poria cocos, carry out wind-force selection and go the removal of impurity, using a length of 30 points during irradiation
The ultraviolet lamp disinfection of clock, is ground into thick end by active compound or is cut into medicine materical crude slice, add water to cook 3 times, 5-8 times of active compound gross mass is added every time
Water logging do not have active compound and be heated to boiling after immersion 1-1.5 hour of 20-25 DEG C of room temperature, continuous heating is separated pan-fried after 1-1.5 hour
Go out liquid, collect and merge three fried liquid, by the fried liquid after merging under the conditions of pressure 20-25MPa, 50-60 DEG C of temperature
Matter, sedimentation, filtration, filtrate, which is concentrated into, obtains relative density in the clear cream that 80-90 DEG C is 1.3-1.35；
（2）By step（1）Clear cream inlet temperature be 135-150 DEG C, outlet temperature be 80-95 DEG C, intake is 0.9m3/
Be spray-dried under conditions of min, obtain spray powder, carry out wet granulation, with fashion of extrusion by 14-22 eye mesh screens or
Sieve plate, is made uniform particle, places into whole grain in Fastgranulatemachine and is made into the particle that size is 40 mesh, then carries out boiling dry
It is dry, drying temperature be 60-80 DEG C, it is to be dried after moisture content of material be 2% when, by obtained particle carry out content inspection with
Granulometry, is according to dosage fitted into bag and packs.
Another of the invention technical scheme is：A kind of herbaceous plant solid beverage of relieving insomnia symptom, in terms of active compound, bag
Include the component of following weight proportion：25-40 grams of wheat, 3-5 grams of radix glycyrrhizae, 9-15 grams of jujube, 9-15 grams of lily, spina date seed 9-15
Gram, 9-15 grams of Chinese yam, 9-15 grams of Poria cocos, 9-15 grams of longan, 9-15 grams of rose.
Preferably, the herbaceous plant solid beverage of the relieving insomnia symptom is in terms of active compound, including following weight proportion
Component：30-35 grams of wheat, 3-5 grams of radix glycyrrhizae, 10-12 grams of jujube, 10-12 grams of lily, 10-12 grams of spina date seed, 10-12 grams of Chinese yam,
10-12 grams of Poria cocos, 10-12 grams of longan, 10-12 grams of rose.
Preferably, the herbaceous plant solid beverage of the relieving insomnia symptom is in terms of active compound, including following weight proportion
Component：30 grams of wheat, 3 grams of radix glycyrrhizae, 10 grams of jujube, 10 grams of lily, 10 grams of spina date seed, 10 grams of Chinese yam, 10 grams of Poria cocos, longan 10
Gram, 10 grams of rose.
More excellent, the herbaceous plant solid beverage of the relieving insomnia symptom is in terms of patent medicine, including following weight proportion
Component：3 grams of wheat, 0.3 gram of radix glycyrrhizae, 1 gram of jujube, 1 gram of lily, 1 gram of spina date seed, 1 gram of Chinese yam, 1 gram of Poria cocos, 1 gram of longan, rose
Spend 1 gram.
According to above-mentioned technical proposal, the present invention also provides a kind of herbaceous plant solid beverage of above-mentioned relieving insomnia symptom
Preparation method, comprises the following steps：
（1）Take the active compound component of following weight proportion：25-40 grams of wheat, 3-5 grams of radix glycyrrhizae, 9-15 grams of jujube, 9-15 grams of lily,
9-15 grams of spina date seed, 9-15 grams of Chinese yam, 9-15 grams of Poria cocos, 9-15 grams of longan, 9-15 grams of rose, carry out wind-force selection and remove
Impurity, using the ultraviolet lamp disinfection of a length of 30 minutes during irradiation, is ground into thick end by active compound or is cut into medicine materical crude slice, add water to cook 3 times,
The water logging for adding 5-8 times of active compound gross mass every time there is not active compound and is heated to boiling after immersion 1-1.5 hours of 20-25 DEG C of room temperature, holds
After continuous heating 1-1.5 hours, fried liquid is separated, collects and merges three fried liquid, by the fried liquid after merging in pressure 20-
Homogeneous, sedimentation, filtration under the conditions of 25MPa, 50-60 DEG C of temperature, it is 1.3- that filtrate, which is concentrated into and obtains relative density at 80-90 DEG C,
1.35 clear cream；
（2）By step（1）Clear cream inlet temperature be 135-150 DEG C, outlet temperature be 80-95 DEG C, intake is 0.9m3/
Be spray-dried under conditions of min, obtain spray powder, carry out wet granulation, with fashion of extrusion by 14-22 eye mesh screens or
Sieve plate, is made uniform particle, places into whole grain in Fastgranulatemachine and is made into the particle that size is 40 mesh, then carries out boiling dry
It is dry, drying temperature be 60-80 DEG C, it is to be dried after moisture content of material be 2% when, by obtained particle carry out content inspection with
Granulometry, is according to dosage fitted into bag and packs.
The effect of the active compound of the herbaceous plant solid beverage of relieving insomnia symptom of the present invention and effect are as follows：
Wheat：Main product claims Huai wheat in the wheat of yangtse-huaihe region, sweet, salty, cool, and energy qi-restoratives is damaged, and strengthening the spleen and stomach, clearind deficient heat, diuresis is supported
Kidney, has the effect of nourishing heart and brings down a fever, and body fluid is not disturbed for fire, and vexed not peaceful available for treating, insomnia is dirty dry.
Radix glycyrrhizae：Property sweet taste, the thoughts of returning home, lung, spleen, stomach, tool are invigorated the spleen and benefited qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain,
Coordinating the drug actions of a prescription；For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus,
Alleviate drug toxicity, strong.
Jujube：Also known as jujube, sweet warm-natured, taste warp, there is tonifying middle-Jiao and Qi, nourishing blood and tranquilization relaxes the function of the property of medicine, can made
Oxygen content enhancing, nourishing systemic cell in blood.
Lily：There is increasing leukocyte, tool removing toxic substances, the stomach invigorating of reason spleen, dampness removing disperse accumulations, antitoxic heart-soothing and sedative, promotion blood are followed
The effects such as ring.Cure mainly the diseases such as overstrain cough, hemoptysis, dysphoria palpitates with fear.
Spina date seed：Also known as jujube kernel, mountain jujube benevolence, wild jujube, there is alkaloid, a variety of pharmaceutical components such as saponin(e and flavones have
Nourishing heart tonifying liver, antitoxic heart-soothing and sedative, arrest sweating, effect promoted the production of body fluid cures mainly restlessness of asrhenia type and insomnia, horrified to much dream, body void hidrosis, injury thirst.
Chinese yam：Also known as Chinese yam, native potato, sweet potato Chinese yam, RHIIZOMA DIOSCOREAE from Henan of China, Chinese yam, white Chinese yam, strong with nourishing, aid digestion, holds back void
The effect of sweat, antidiarrheal, cure mainly that insufficiency of the spleen diarrhoea, cough due to deficiency of the lung, diabetes are quenched one's thirst, oliguria frequency, seminal emission, women is with lower and digest not
Good chronic enteritis.
Poria cocos：Yun Ling, Song Ling, Fu spirit are commonly called as, shape can strengthen as sweet potato, crust dark brown, the inside white or pink
Body's immunity；There is diuresis, the discharge of the electrolyte such as potassium, sodium, chlorine in urine can be increased；There are calm and protection liver, suppression
The generation of ulcer processed, hypoglycemic, anti-radiation etc. are acted on；Available for diseases such as confused and worried, palpitaition, insomnias.
Longan：Warm-natured sweet, heart-spleen boosting fills blood, with well having nourishing benefiting action, available for heart and spleen deficiency, gas
The diseases such as having a sleepless night caused by blood is not enough, forgetful, palpitation with fear, dizziness.
Rose：Property sweet slight bitter, warm, nontoxic, regulating the flow of vital energy Xie Yu and blood dissipate the stasis of blood, cure mainly stomachache due to emotional depression and the hyperactive liver-qi attacking the stomach, new wandering arthritis long, spit blood
Spitting of blood, irregular menstruation, leukorrhea with reddish discharge, dysentery, acute mastitis, pyogenic infections.
The present invention is using the herbal raw material of pure Chinese medicine, it then follows " monarch ", " minister ", " assistant ", " making " principle, and wheat is sweet to be slightly cold, acid
Jujube kernel sweet taste, nourishing the liver bushing, relieving restlessness is calmed the nerves, and is altogether monarch drug in a prescription；Radix glycyrrhizae is sweet flat, benefiting heart-QI, and middle emergency, Poria cocos calming heart peace
God, is altogether ministerial drug；The sweet Wen Zhirun of jujube, QI invigorating moisturizes emergency, is adjutant with；Radix glycyrrhizae life is used, and middle emergency, to make medicine；Plus
With lily, Chinese yam, longan, rose, all medicines share, flat benefit in sweet flavor, nourishing heart adjusts liver to calm the nerves, and clearing heat and relieving fidgetness puts forth effort on essence of releiving
Refreshing pressure, antianxiety, solution is depressed, and no dependence has no toxic side effect.
Application method and consumption：The consumption of herbaceous plant solid beverage of the present invention depends on age, health of user etc.
Factor.It is used as guidance：Herbaceous plant solid beverage of the present invention is 1 bag every time into survival dose, is no more than 2 times, sleeps daily daily
Before take, machine, car must not be driven because this product has sleeping effect, after taking, ship, work high above the ground, mechanical work and operation is engaged in
Precision instrument etc. requires safety activities.
Any form, including granule, lotion and oral liquid can be made in herbaceous plant solid beverage of the present invention, full
The adaptability of sufficient user.
Embodiment
Below by way of specific embodiment, the invention will be further described.
The herbaceous plant solid beverage of the relieving insomnia symptom of the present invention of embodiment 1, is matched somebody with somebody by the weight below in terms of active compound
The component of ratio：40 grams of wheat, 5 grams of radix glycyrrhizae, 15 grams of jujube, 15 grams of lily, 15 grams of spina date seed, 15 grams of Chinese yam, 15 grams of Poria cocos, it is made
Standby step is as follows；
（1）Wheat, radix glycyrrhizae, jujube, lily, spina date seed, Chinese yam, Poria cocos are taken, wind-force selection is carried out and goes the removal of impurity, using irradiation
The Shi Changwei ultraviolet lamp disinfections of 30 minutes, thick end is ground into by active compound, is added water to cook 3 times, and 8 times of active compound gross mass is added every time
Water logging there is not active compound and is heated to boiling after the immersion 1.5 hours of 25 DEG C of room temperature, and continuous heating separates fried liquid after 1.5 hours, collects
And merge three fried liquid, homogeneous, sedimentation, filtration, filter under the conditions of pressure 25MPa, temperature 60 C by the fried liquid after merging
Liquid, which is concentrated into, obtains relative density in the clear cream that 90 DEG C are 1.35；
（2）By step（1）Clear cream inlet temperature be 150 DEG C, outlet temperature be 95 DEG C, intake is 0.9m3/ min bar
It is spray-dried under part, obtains spray powder, is carried out wet granulation, with fashion of extrusion by 20 eye mesh screens, be made uniform
Grain, places into whole grain in Fastgranulatemachine and is made into the particle that size is 40 mesh, then carry out fluidized drying, drying temperature is 80
DEG C, it is to be dried after moisture content of material when being 2%, obtained particle is subjected to content inspection and granulometry, according to dosage loaded
Packed in bag.
The herbaceous plant solid beverage of the relieving insomnia symptom of the present invention of embodiment 2, is matched somebody with somebody by the weight below in terms of active compound
The component of ratio：30 grams of wheat, 3 grams of radix glycyrrhizae, 10 grams of jujube, 10 grams of lily, 10 grams of spina date seed, 10 grams of Chinese yam, 10 grams of Poria cocos, it is made
Standby step is as follows；
（1）Wheat, radix glycyrrhizae, jujube, lily, spina date seed, Chinese yam, Poria cocos are taken, wind-force selection is carried out and goes the removal of impurity, using irradiation
The Shi Changwei ultraviolet lamp disinfections of 30 minutes, thick end is ground into by active compound, is added water to cook 3 times, and 6 times of active compound gross mass is added every time
Water logging there is not active compound and is heated to boiling after the immersion 1.2 hours of 22 DEG C of room temperature, and continuous heating separates fried liquid after 1.2 hours, collects
And merge three fried liquid, homogeneous, sedimentation, filtration, filter under the conditions of pressure 25MPa, 55 DEG C of temperature by the fried liquid after merging
Liquid, which is concentrated into, obtains relative density in the clear cream that 85 DEG C are 1.3；
（2）By step（1）Clear cream inlet temperature be 145 DEG C, outlet temperature be 90 DEG C, intake is 0.9m3/ min bar
It is spray-dried under part, obtains spray powder, is carried out wet granulation, with fashion of extrusion by 22 eye mesh screens, be made uniform
Grain, places into whole grain in Fastgranulatemachine and is made into the particle that size is 40 mesh, then carry out fluidized drying, drying temperature is 75
DEG C, it is to be dried after moisture content of material when being 2%, obtained particle is subjected to content inspection and granulometry, according to dosage loaded
Packed in bag.
The herbaceous plant solid beverage of the relieving insomnia symptom of the present invention of embodiment 3, is matched somebody with somebody by the weight below in terms of active compound
The component of ratio：25 grams of wheat, 3 grams of radix glycyrrhizae, 9 grams of jujube, 9 grams of lily, 9 grams of spina date seed, 9 grams of Chinese yam, 9 grams of Poria cocos, it prepares step
It is rapid as follows；
（1）Wheat, radix glycyrrhizae, jujube, lily, spina date seed, Chinese yam, Poria cocos are taken, wind-force selection is carried out and goes the removal of impurity, using irradiation
The Shi Changwei ultraviolet lamp disinfections of 30 minutes, thick end is ground into by active compound, is added water to cook 3 times, and 5 times of active compound gross mass is added every time
Water logging there is not active compound and is heated to boiling after the immersion 1 hour of 20 DEG C of room temperature, and continuous heating separates fried liquid, collect and close after 1 hour
And three fried liquid, homogeneous, sedimentation, filtration under the conditions of pressure 20MPa, temperature 50 C by the fried liquid after merging, filtrate is dense
It is reduced to and obtains relative density in the clear cream that 80 DEG C are 1.3；
（2）By step（1）Clear cream inlet temperature be 135 DEG C, outlet temperature be 80 DEG C, intake is 0.9m3/ min bar
It is spray-dried under part, obtains spray powder, is carried out wet granulation, with fashion of extrusion by 14 mesh sieve plates, be made uniform
Grain, places into whole grain in Fastgranulatemachine and is made into the particle that size is 40 mesh, then carry out fluidized drying, drying temperature is 60
DEG C, it is to be dried after moisture content of material when being 2%, obtained particle is subjected to content inspection and granulometry, according to dosage loaded
Packed in bag.
The herbaceous plant solid beverage of the relieving insomnia symptom of the present invention of embodiment 4, is matched somebody with somebody by the weight below in terms of active compound
The component of ratio：40 grams of wheat, 5 grams of radix glycyrrhizae, 15 grams of jujube, 15 grams of lily, 15 grams of spina date seed, 15 grams of Chinese yam, 15 grams of Poria cocos, longan
15 grams, 15 grams of rose, its preparation process is as follows；
（1）Wheat, radix glycyrrhizae, jujube, lily, spina date seed, Chinese yam, Poria cocos, longan, rose are taken, wind-force selection is carried out and removes
Impurity, using the ultraviolet lamp disinfection of a length of 30 minutes during irradiation, is cut into medicine materical crude slice by active compound, adds water to cook 3 times, active compound is added every time
The water logging that 8 times of gross mass there is not active compound and is heated to boiling after the immersion 1.5 hours of 25 DEG C of room temperature, and continuous heating is after 1.5 hours, separation
Fried liquid, collects and merges three fried liquid, by the fried liquid after merging under the conditions of pressure 25MPa, temperature 60 C homogeneous, heavy
Drop, filtration, filtrate, which is concentrated into, obtains relative density in the clear cream that 90 DEG C are 1.35；
（2）By step（1）Clear cream inlet temperature be 150 DEG C, outlet temperature be 95 DEG C, intake is 0.9m3/ min bar
It is spray-dried under part, obtains spray powder, is carried out wet granulation, with fashion of extrusion by 20 eye mesh screens, be made uniform
Grain, places into whole grain in Fastgranulatemachine and is made into the particle that size is 40 mesh, then carry out fluidized drying, drying temperature is 75
DEG C, it is to be dried after moisture content of material when being 2%, obtained particle is subjected to content inspection and granulometry, according to dosage loaded
Packed in bag.
The herbaceous plant solid beverage of the relieving insomnia symptom of the present invention of embodiment 5, is matched somebody with somebody by the weight below in terms of active compound
The component of ratio：30 grams of wheat, 3 grams of radix glycyrrhizae, 10 grams of jujube, 10 grams of lily, 10 grams of spina date seed, 10 grams of Chinese yam, 10 grams of Poria cocos, longan
10 grams, 10 grams of rose, its preparation process is as follows；
（1）Wheat, radix glycyrrhizae, jujube, lily, spina date seed, Chinese yam, Poria cocos, longan, rose are taken, wind-force selection is carried out and removes
Impurity, using the ultraviolet lamp disinfection of a length of 30 minutes during irradiation, is cut into medicine materical crude slice by active compound, adds water to cook 3 times, active compound is added every time
The water logging that 6 times of gross mass there is not active compound and is heated to boiling after the immersion 1.2 hours of 22 DEG C of room temperature, and continuous heating is after 1.2 hours, separation
Fried liquid, collects and merges three fried liquid, by the fried liquid after merging under the conditions of pressure 25MPa, 55 DEG C of temperature homogeneous, heavy
Drop, filtration, filtrate, which is concentrated into, obtains relative density in the clear cream that 85 DEG C are 1.3；
（2）By step（1）Clear cream inlet temperature be 145 DEG C, outlet temperature be 90 DEG C, intake is 0.9m3/ min bar
It is spray-dried under part, obtains spray powder, is carried out wet granulation, with fashion of extrusion by 22 eye mesh screens, be made uniform
Grain, places into whole grain in Fastgranulatemachine and is made into the particle that size is 40 mesh, then carry out fluidized drying, drying temperature is 75
DEG C, it is to be dried after moisture content of material when being 2%, obtained particle is subjected to content inspection and granulometry, according to dosage loaded
Packed in bag.
The herbaceous plant solid beverage of the relieving insomnia symptom of the present invention of embodiment 6, is matched somebody with somebody by the weight below in terms of active compound
The component of ratio：25 grams of wheat, 3 grams of radix glycyrrhizae, 9 grams of jujube, 9 grams of lily, 9 grams of spina date seed, 9 grams of Chinese yam, 9 grams of Poria cocos, 9 grams of longan,
9 grams of rose, its preparation process is as follows；
（1）Wheat, radix glycyrrhizae, jujube, lily, spina date seed, Chinese yam, Poria cocos, longan, rose are taken, wind-force selection is carried out and removes
Impurity, using the ultraviolet lamp disinfection of a length of 30 minutes during irradiation, is cut into medicine materical crude slice by active compound, adds water to cook 3 times, active compound is added every time
The water logging that 5 times of gross mass there is not active compound and is heated to boiling after the immersion 1 hour of 20 DEG C of room temperature, and continuous heating is separated fried after 1 hour
Liquid, collects and merges three fried liquid, by the fried liquid after merging under the conditions of pressure 20MPa, temperature 50 C homogeneous, sedimentation,
Filtration, filtrate, which is concentrated into, obtains relative density in the clear cream that 80 DEG C are 1.3；
（2）By step（1）Clear cream inlet temperature be 135 DEG C, outlet temperature be 80 DEG C, intake is 0.9m3/ min bar
It is spray-dried under part, obtains spray powder, is carried out wet granulation, with fashion of extrusion by 14 mesh sieve plates, be made uniform
Grain, places into whole grain in Fastgranulatemachine and is made into the particle that size is 40 mesh, then carry out fluidized drying, drying temperature is 60
DEG C, it is to be dried after moisture content of material when being 2%, obtained particle is subjected to content inspection and granulometry, according to dosage loaded
Packed in bag.
Herbaceous plant solid beverage made by the embodiment 2 of embodiment 7 is anticonvulsion to mouse and rabbit tranquilizing soporific etc. to be made
Influence is tested.
Concentration needed for herbaceous plant solid beverage made from embodiment 2 is made into distilled water carries out following experiment：1. it is right
The influence of central nervous system（Influence to mouse electric shock anger；The influence grappled to mouse；Influence to spontaneous activity in mice；
The influence of mice convulsion is induced dimefline；The influence of mice convulsion is induced strychnine；On the electric convulsive influence of mouse；To penta
The influence of the barbital sodium inducing mouse length of one's sleep；Influence to mouse transfer rod）；2. to the shadow of rabbits blood pressure, breathing and heart rate
Ring；3. to the influence of female mice sexual gland（Influence to mouse uterine weight；To the shadow of ovariectomized mouse vaginal keratinocyte
Ring）.
As a result：Obtained herbaceous plant solid beverage can significantly improve the voltage threshold for enraging mouse；Extend the lattice of mouse
Struggle against incidence；Suppress spontaneous activity in mice；Reduce the mice convulsion incidence that dimefline and strychnine induce；Extend amobarbital
Sodium lures different mouse sleep time, shows with maincenter calmness, hypnosis and anticonvulsant action.Obtained herbaceous plant solid beverage
Young mouse uterus weight, ovariectomized mouse vaginal epithelial cell are had no significant effect, the effect of no estrogen sample.
In addition, experiment display, obtained herbaceous plant solid beverage is to rabbits blood pressure, breathing, heart rate, electrocardiogram without bright
Development rings.
Herbaceous plant solid beverage made by the embodiment 2 of embodiment 8 is to the effect of Central Nervous System of Mouse and smooth muscle
Influence experiment.
Experiment takes rat to carry out the screening of Neuropharmacology to herbaceous plant solid beverage made from embodiment 2 and observe it
Influence to rat autogenic movement.Cavy is taken to carry out the observation influenceed on isolated smooth muscle contraction.
As a result：In Neuropharmacology screening, significant effect is had no, the length of one's sleep of hexobarbital is slightly prolonged
Long effect.Amount of exercise, which is reduced, to be observed after mouth is raised 3-4 days to rat autogenic movement amount.For the effect of isolated smooth muscle,
Its extract is with 5 × 10-3Guinea pig ileum caused by g/ml (concentration in water tank) can suppress histamine, acetylcholine is shunk.It is right
In rat uterus contraction with 2 × 10-3G/ml concentration can then be completely inhibited.
Influence experiment of the herbaceous plant solid beverage to mouse effect in increasing leukocyte made by the embodiment 2 of embodiment 9.
Female mice 30 is taken, 3 groups is randomly divided into, endoxan is given respectively（Intraperitoneal injection）70mg/ (kg/ days), together
When high dose group gavage 66.8g/ (kg/ days) with herbaceous plant solid beverage medicine soup made from embodiment 2, low dose group is with being made
Herbaceous plant solid beverage medicine soup gavage 33.4g/ (kg/ days), control group gives physiological saline, totally 9 days.Pcissors fault vein takes
Blood, carries out white blood cell count(WBC), the next day 1 time, and weigh body weight daily, calculate average value.
As a result：After endoxan, each group murine interleukin declines rapidly, reaches within 3rd minimum point, but 2 groups of administration are white
Cellular level is consistently higher than control group.Especially high dose group, except fall time delay, amplitude reduce outer, leucocyte level time
Rise also very fast, level before even more than treating for 7-9 day, deactivation Chinese medicine after 2 days is still significantly higher than control group, and low dose group
Though leucocyte level starts to be closer to high dose group, go up slower, after being discontinued 2 leucocyte decline it is rapid, with compareing
Group compares that there was no significant difference.Illustrate that the power of obtained herbaceous plant solid beverage effect in increasing leukocyte is relevant with dosage.
Experiment is it was additionally observed that using after endoxan, different degrees of decline occur in mouse weight and health status, but 2 groups of administration is equal
Better than control group, point out we that there is good protective effect to toxicity caused by endoxan, be one and take a tonic or nourishing food to build up one's health strong well
Strong agent.
The influence experiment that herbaceous plant solid beverage made by the embodiment 2 of embodiment 10 is acted on human body oestrogen-like hormone.
The result of Via vagina cytolgical examination shows that 95 patient's singles check hormonal readiness in 133, and 8 have slight
Influence, 12 have moderate influence, and 20 have height to influence；24 have slight low, 13 have moderate it is low, 18 have highly low
Fall.The result that serum pituitary follicle-stimulating hormone is determined：There are 18 to be more than 50ml units/ml in 20；14 climacteric minimums
29.8, peak 203.5, average 67.88 ± 59.0.Herbaceous plant solid beverage made from speculating embodiment 2 has oestrogen-like hormone
Effect, so as to improve the unrest of hypothalamic-pituitary-ovarian axis function, serves therapeutic action.Controversies in hormone replacement in the elderly can control to dry
The number of times that heat and awakening occur.Equally there is relatively satisfactory effect to warming, having a sleepless night with Chinese medicine.
The toxicity test of herbaceous plant solid beverage made by the embodiment 2 of embodiment 11 to mouse.
Concentration needed for herbaceous plant solid beverage made from embodiment 2 is made into distilled water carries out following toxicity test：
1. acute toxicity test：Mouse is divided into 3 groups, every group 20.1 gastric infusion at 18-23 DEG C of room temperature（Concentrate 0.6ml/
Only）, death toll is observed after 7 days；2. long term toxicity test：Rat 120, is randomly divided into 4 groups, i.e. saline control group, this
Invention medicine soup 10,20,30g/kg groups, gastric infusion, one time a day.Before administration, it is administered 1.5 months and is respectively checked after being administered 3 months
1 liver function（SGPT）, renal function（BUN）, hemoglobin, total white blood cells and differential counting, and to rats eating, outward appearance,
The ordinary circumstances such as activity, excrement are observed.Administration 3 months after, every group take 10 rats, sacrificed by exsanguination after make general pathology inspection
Look into and the heart, liver, lung, kidney, the check pathological section of spleen and stomach.
As a result：1. acute toxicity test：Mouse LD50 medicine soup gastric infusion LD50 of the present invention>80g/kg.2. long term toxicity
Experiment：From the 1st and the 2nd week：Female rats 10,20g/kg groups and male rat 10,20,30g/kg group increased weight values it is bright
The aobvious body weight higher than the control group same period is rised in value, and weightening trend is maintained 3 months as long as, and male becomes apparent from than female.Serum GPT and
BUN, hemoglobin, total white blood cells and differential counting value are compared with saline control group without substantially change, 1.5 after administration
The moon and 3 months check statistics, belong to normal range (NR).During administration, freely, diet, excrement normal rule, nothing alarm hair to activities in rats
Deng adverse reaction.The heart, lung, liver,kidney,spleen and stomach after being administered 3 months, visual inspection and cut sections for microscopic examination are without substantially change.
Embodiment described above only expresses the several embodiments of the present invention, but therefore can not be interpreted as to this hair
The limitation of bright the scope of the claims.It should be pointed out that for the person of ordinary skill of the art, not departing from present inventive concept
On the premise of, various modifications and improvements can be made, these belong to protection scope of the present invention.Therefore, patent of the present invention
Protection domain should be determined by the appended claims.
Claims (9)
1. a kind of herbaceous plant solid beverage of relieving insomnia symptom, it is characterised in that：In terms of active compound, including following weight proportion
Component：25-40 grams of wheat, 3-5 grams of radix glycyrrhizae, 9-15 grams of jujube, 9-15 grams of lily, 9-15 grams of spina date seed, 9-15 grams of Chinese yam, Fu
9-15 grams of Siberian cocklebur.
2. the herbaceous plant solid beverage of relieving insomnia symptom according to claim 1, it is characterised in that：In terms of active compound,
Also include the component of following weight proportion：9-15 grams of longan, 9-15 grams of rose.
3. a kind of herbaceous plant solid beverage of relieving insomnia symptom according to claim 1, it is characterised in that：With active compound
Meter, includes the component of following weight proportion：30-35 grams of wheat, 3-5 grams of radix glycyrrhizae, 10-12 grams of jujube, 10-12 grams of lily, wild jujube
10-12 grams of benevolence, 10-12 grams of Chinese yam, 10-12 grams of Poria cocos.
4. the herbaceous plant solid beverage of relieving insomnia symptom according to claim 3, it is characterised in that：In terms of active compound,
Also include the component of following weight proportion：10-12 grams of longan, 10-12 grams of rose.
5. a kind of herbaceous plant solid beverage of relieving insomnia symptom according to claim 1, it is characterised in that：With active compound
Meter, includes the component of following weight proportion：30 grams of wheat, 3 grams of radix glycyrrhizae, 10 grams of jujube, 10 grams of lily, 10 grams of spina date seed, Chinese yam
10 grams, 10 grams of Poria cocos.
6. the herbaceous plant solid beverage of relieving insomnia symptom according to claim 5, it is characterised in that：In terms of active compound,
Also include the component of following weight proportion：10 grams of longan, 10 grams of rose.
7. the herbaceous plant solid beverage of relieving insomnia symptom according to claim 1 or 2, it is characterised in that：It is prepared
Method comprises the following steps：
（1）Each active compound component is taken, wind-force selection is carried out and goes the removal of impurity, using the ultraviolet lamp disinfection of a length of 30 minutes during irradiation,
Active compound is ground into thick end or medicine materical crude slice is cut into, added water to cook 3 times, the water logging that 5-8 times of active compound gross mass is added every time there is not active compound simultaneously
Boiling is heated to after immersion 1-1.5 hours of 20-25 DEG C of room temperature, continuous heating separates fried liquid, collect and close after 1-1.5 hours
And three fried liquid, homogeneous, sedimentation, filtration under the conditions of pressure 20-25MPa, 50-60 DEG C of temperature by the fried liquid after merging,
Filtrate, which is concentrated into, obtains relative density in the clear cream that 80-90 DEG C is 1.3-1.35；
（2）By step（1）Clear cream inlet temperature be 135-150 DEG C, outlet temperature be 80-95 DEG C, intake is 0.9m3/
Be spray-dried under conditions of min, obtain spray powder, carry out wet granulation, with fashion of extrusion by 14-22 eye mesh screens or
Sieve plate, is made uniform particle, places into whole grain in Fastgranulatemachine and is made into the particle that size is 40 mesh, then carries out boiling dry
It is dry, drying temperature be 60-80 DEG C, it is to be dried after moisture content of material be 2% when, by obtained particle carry out content inspection with
Granulometry, is according to dosage fitted into bag and packs.
8. a kind of herbaceous plant solid beverage of relieving insomnia symptom, it is characterised in that：In terms of patent medicine, including following weight proportion
Component：3 grams of wheat, 0.3 gram of radix glycyrrhizae, 1 gram of jujube, 1 gram of lily, 1 gram of spina date seed, 1 gram of Chinese yam, 1 gram of Poria cocos.
9. the herbaceous plant solid beverage of relieving insomnia symptom according to claim 8, it is characterised in that：In terms of patent medicine,
Also include the component of following weight proportion：1 gram of longan, 1 gram of rose.
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